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digital imaging and communication in medicine ( dicom ) network protocols are widely used for reviewing images and performing primary diagnosis within radiology and other imaging departments , by means of picture archiving and communication system ( pacs ) .
dicom , which is the communication standard for medical ima... | multiprotocol medical imaging communication through the internet is more flexible than the tight dicom transfers .
this paper introduces a modular multiprotocol teleradiology architecture that integrates dicom and common internet services ( based on web , ftp , and e - mail ) into a unique operational domain . the ex... |
type 2 diabetes ( t2d ) is a chronic metabolic disorder , which results from impaired insulin secretion and action in target tissues [ 1 , 2 ] .
it is reported that there will be 280 million cases suffering from t2d in 2011 .
the prevalence trend is considered to be ascribed to genetic variants and environmental fa... | we sought to explore the molecular mechanism of type 2 diabetes ( t2d ) and identify potential drug targets and candidate agents for t2d treatment . the differentially expressed genes ( degs )
were assessed between human pancreatic islets with t2d and normal islets .
the dysfunctional pathways , the potential trans... |
the
buchner reaction of metal carbenes generated from diazocarboxylates
and related substrates has been observed under catalytic or stoichiometric
conditions using copper(i ) , silver(i ) , gold(i ) , rhodium(ii ) , and ruthenium complexes .
the copper- and rhodium - catalyzed processes have often
been used i... | the fate of the aryl
gold(i ) carbenes generated by retro - buchner
reaction of ortho - substituted 7-aryl-1,3,5-cycloheptatrienes is dependent
on the constitution of the ortho substituent .
indenes and fluorenes
are obtained by intramolecular reaction of highly electrophilic gold(i )
carbenes with alkenes ... |
vertically infected children may have significant human immunodeficiency virus ( hiv ) drug resistance due to non - suppressive regimens and/or inadequate adherence . as a result of the lack of experience with newer drugs
we describe a case of a successful treatment based on dolutegravir in a patient with multidrug c... | the management of multidrug - resistant human immunodeficiency virus ( mdr hiv ) infections in children is particularly challenging due to the lack of experience with new drugs .
dolutegravir , combined with an optimized antiretroviral background therapy , is promising for the treatment of mdr hiv and has been approv... |
we monitored mers - cov specific antibody levels in 11 pairs of camel dams and their calves at monthly intervals over the course of 1 year postparturition .
these animals were born and raised on a closed commercial camel dairy farm in the united arab emirates that had a strict animal health and biosecurity program .... | knowledge about immunity to middle east respiratory syndrome coronavirus ( mers - cov ) in dromedary camels is essential for infection control and vaccination .
a longitudinal study of 11 dam calf pairs showed that calves lose maternal mers - cov antibodies 56 months postparturition and are left susceptible to infec... |
accurate estimation of the preload status and optimal intraoperative fluid management is a major concern in patients undergoing liver transplantation .
the most direct clinical correlate of ventricular preload is the end - diastolic ventricular volume .
although traditional static preload indices , including centra... | background : the right ventricular end - diastolic volume index ( rvedvi ) is a good indicator of preload in patients undergoing liver transplantation . although dynamic indices , such as stroke volume variation ( svv ) , have been used as reliable indicators in predicting fluid responsiveness , the evaluation of the r... |
systemic lupus erythematosus ( sle ) is a chronic systemic autoimmune disease of unknown etiology .
it can manifest in the inflammation of various organs including skin , heart , joints , blood vessels , liver , kidneys , and nonetheless ocular tissues such as cornea [ 1 , 2 ] .
sle is characterized by a hypersensi... | purpose . investigation of dry eye and corneal langerhans cells ( lcs ) in systemic lupus erythematosus ( sle ) . methods . prospective consecutive case series of 27 sle patients and 27 control subjects .
dry eye was evaluated by lid - parallel conjunctival folds ( lipcof ) , schirmer test , tear break - up time ( tb... |
white matter lesions ( wmls ) are commonly observed as hyperintensities on t2 and fluid attenuated inversion recovery ( flair ) magnetic resonance imaging ( mri ) sequences in stroke patients with small vessel disease ( svd ) and may reflect the ischemic components of vascular brain injury .
although the precise dise... | white matter lesions ( wmls ) are commonly observed in stroke patients with small vessel disease ( svd ) and are thought to result from a progressive , irreversible disease process following arteriolosclerosis . in this study
, we report a case of partial disappearance of wmls 1 year after a lacunar stroke in a 69-ye... |
noninvasive assessment of arterial stiffness has been proposed for individual cardiovascular risk evaluation and early detection of vascular damage associated with hypertension and/or atherosclerosis [ 14 ] . among the different noninvasive methods used to assess arterial stiffness
the carotid - femoral pulse wave ve... | carotid - femoral pulse wave velocity ( pwv ) has emerged as the gold standard for non - invasive evaluation of aortic stiffness ; absence of standardized methodologies of
study and lack of normal and reference values have limited a wider clinical implementation .
this work was carried out in a uruguayan ( south am... |
we present here a 30-year - old female patient presenting as a case of hard palate perforation .
after thorough evaluation , a biopsy from that site was taken , which shows granulomatous inflammation and positive for tuberculosis polymerase chain reaction ( tb - pcr ) .
tb of the palate is a rare entity and that to... | tuberculosis ( tb ) is a major public health problem in developing countries .
lung is most common affected organ , however extra pulmonary tuberculosis ( eptb ) is also not uncommon .
the clinical manifestations of eptb may be non - specific that mimics other diseases and is usually misdiagnosed .
therefore , hi... |
i used published data reporting possible incubation periods for 17 patients ( 6,7 ) plus data from two case - patients in an unpublished database maintained at the centers for disease control and prevention ( cdc ) .
i built a simulation model in a standard computer spreadsheet ( excel 2000 , microsoft corp , redmond... | many severe acute respiratory syndrome ( sars ) patients have multiple possible incubation periods due to multiple contact dates .
multiple contact dates can not be used in standard statistical analytic techniques , however .
i present a simple spreadsheet - based method that uses multiple contact dates to calculat... |
inflammatory bowel disease ( ibd ) is a chronic inflammatory condition in the small and large bowel , and includes two major clinical forms , crohn 's disease ( cd ) and ulcerative colitis ( uc).1 although the exact causes of ibd are largely unknown , early studies aimed at identifying the genetic factors associated wi... | immature myeloid cells , also known as myeloid - derived suppressor cells ( mdscs ) , include neutrophilic and monocytic myeloid cells , and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation , inflammatory bowel disease ( ibd ) patients , and tumor tissues
. however , t... |
disability is a major issue for us veterans and , thus , a significant concern of the veterans health administration ( vha ) of the us department of veterans affairs ( va ) . in 2015 , > 4.5 million veterans received compensation for service - connected disabilities , including 42.5% gulf war era veterans ( 1990till da... | the number of us veterans with disabilities has increased in recent years as service members have returned home with extensive injuries and veterans from previous wars acquire functional limitations as a consequence of aging with chronic diseases .
veterans with severe disabilities need assistance and support to main... |
it is well known that population ageing , sometimes called demographic ageing , is now a worldwide phenomenon [ , p. 36 ] . at the same time
, age is considered the main risk factor leading to dementia . according to traynor et al . ,
dementia is the most likely condition to be associated with profound or severe c... | backgroundservices in specialized day - care units for individuals with dementia are set up to enable these persons to live in their own home .
the purpose of this paper is to discern the experiences of families with these services while caring for a close relative with dementia.methodlongitudinal interviews with 8 f... |
kidney stone is one of the common diseases of human society , which is demonstrated in the form of renal colic .
evidences indicate that renal colic is one of the most painful conditions that require urgent pain relief treatment .
patients suffering from renal colic do not usually recover from pain by using oral pa... | background : kidney stone is normally treated by opioids with a variety of side - effects including hypotension , respiratory depression and apnea , nausea and vomiting . regarding less complications of intravenous acetaminophen , we aimed to compare it with intravenous morphine in management of renal colic pain.materi... |
hemozoin is a unique
biocrystalline material formed by several
hematophagous organisms , from malaria parasites , to helminths , and
even triatomine insects .
the hemozoin formation pathway
is utilized in order to escape the effects of toxic free heme , which
accumulates in these organisms as a consequence ... | hemozoin is a unique biomineral that
results from the sequestration
of toxic free heme liberated as a consequence of hemoglobin degradation
in the malaria parasite .
synthetic neutral lipid droplets ( snlds )
and phospholipids were previously shown to support the rapid formation
of -hematin , abiological he... |
organic thin films have
attracted high and widespread scientific interest within the past
decade . in particular , films composed of conjugated materials , polymers ,
as well as molecules are of preferred importance .
this is due to their
interesting and advantageous electrical , optical , optoelectronic , ch... | the film growth of the conjugated organic molecule rubicene
on silicon dioxide was studied in detail . since no structural data
of the condensed material were available , we first produced high quality
single crystals from solution and determined the crystal structure .
this high purity material was used to pre... |
osteoarthritis ( oa ) , also known as degenerative arthritis , is most common in the knee joint
and steadily advances the degradation of the joint cartilage .
it is a chronic illness common
to the joints of the low back , hip , and knee that mostly affects middle - aged people and the
elderly1 . for patients wi... | [ purpose ] this study applied proprioceptive circuit exercise to patients with
degenerative knee osteoarthritis and examined its effects on knee joint muscle function
and the level of pain . [ subjects ] in this study , 14 patients with knee osteoarthritis in
two groups , a proprioceptive circuit exercise group ... |
groups of male and female fischer 344 rats , b6c3f1 mice , and hartley guinea pigs were exposed once for 6 hr to mean concentrations of 10.5 , 5.4 , 2.4 , 1.0 , or 0 ( control ) ppm of methyl isocyanate ( mic ) vapor .
rats and mice were also exposed to 20.4 ppm of mic .
the majority of deaths occurred during poste... | |
early enteral feeding is now recognized as one of the fundamentals of critical care practice .
enteral nutrition ( en ) increases gut blood flow , thereby protecting the gastric mucosa .
early feeding results in fewer septic complications , decreased catabolic response to injury , decreased stress ulceration in the... | prokinetic agents are commonly used in intensive care , mainly to aid in early enteral feeding .
the present commentary reviews some of the recently published papers and highlights the lack of a sizable evidence base , as well as the possible importance of euglycaemia in this important clinical area . |
sepsis is a major cause of morbidity and mortality , with an estimated incidence in the pediatric population of 0.56 cases per 1000 annually .
bacterial components and secreted toxins can stimulate massive cytokine release and lead to septic shock , acute respiratory distress syndrome , and death .
it is likely tha... | background . methicillin - resistant staphylococcus aureus ( mrsa ) can stimulate massive cytokine release .
ketamine suppresses tumor necrosis factor ( tnf ) secretion by mrsa - stimulated raw264.7 macrophages , and the mechanism likely involves n - methyl - d - aspartic acid ( nmda ) receptor antagonism .
the dow... |
kinetic resolution
is a valuable tool for the synthesis of enantiopure
materials from racemic mixtures .
typically ,
these reactions entail the rapid reaction of one enantiomer of a racemate
with a chiral catalyst , which allows for the isolation of enantioenriched
unreacted starting material as well as an ... | the
n - heterocyclic carbene and hydroxamic acid cocatalyzed kinetic
resolution of cyclic amines generates enantioenriched amines and amides
with selectivity factors up to 127 . in this report
, a quantum mechanical
study of the reaction mechanism indicates that the selectivity - determining
aminolysis step... |
the general policy popularity of partnership can not be doubted glasby and dickinson note that the term was recorded 11,319 times in 2006 in official parliamentary records , compared with only 38 times in 1989 .
this is reflected in national polices on health ( the remit of the national health service ) and social ... | introductionover the past two decades , the service delivery landscape across health and social care in england has been reshaped in order to separate the commissioning of services from their delivery.policy/practicethe market ethic that underpinned this move has depicted the previously roles as unresponsive to the nee... |
population - based studies have indicated that macs accounts for 3.9% to 19% of colorectal cancer worldwide . according to the world health organization
, mac is an adenocarcinoma in which a substantial amount of mucin ( > 50% of the tumor ) is retained within the tumor .
the oncologic behavior of mac differs from... | abstractmucinous adenocarcinoma ( mac ) is a histological subtype of colorectal cancer .
the oncologic behavior of mac differs from nonmucinous adenocarcinoma ( non - mac ) .
our aim in this study was to characterize patients with colorectal mac through evaluation of a large , institutional - based cohort with long... |
q fever is a zoonosis caused by infection with coxiella burnetii ( rickettsia burnetti ) , a strictly intracellular organism . unlike other rickettsiae , which are transmitted to humans by the bite of contaminated arthropods,1 c. burnetii is generally transmitted through inhalation of infected aerosols .
clinical pol... | q fever is a zoonosis caused by coxiella burnetii .
ocular manifestations are rare in this infection .
we describe the case of a man complaining of an intense retro - orbital headache , fever , arthralgia , and bilateral loss of vision , who showed an anterior uveitis accompanied by exudative bilateral inferior ret... |
it is estimated that medication errors occur in 1.5 million people in the usa annually . in other industrialized countries , it has been reported that adverse events from drugs are a leading cause of injury and death within their health care systems . in this case report
, we report an accidental injection of tranexa... | some factors have been identified as contributing to medical errors , such as labels , appearance and location of ampoules .
we present a case of accidental injection of tranexamic acid instead of bupivacaine during spinal anaesthesia .
one minute after the injection of 3 ml of the solution , the patient developed ... |
synthesis and insertion of membrane proteins
into a lipid bilayer
is a fundamental biophysical process for which many aspects are not
yet understood .
insertion occurs co - translationally via a highly conserved
and specialized membrane channel , the so - called secy translocon , which
possesses a lateral g... | for the vast majority of membrane proteins , insertion
into a membrane
is not direct , but rather is catalyzed by a protein - conducting channel ,
the translocon .
this channel provides a lateral exit into the bilayer
while simultaneously offering a pathway into the aqueous lumen .
the
determinants of a n... |
cervical laminoplasty was introduced in the early 1980s as a successful means of addressing multilevel cervical spinal stenosis secondary to either cervical spondylotic myelopathy ( csm ) or ossification of posterior longitudinal ligament ( opll)23 ) .
the goal of laminoplasty is to indirectly decompress the spinal c... | objectivethe aim of this study was to compare the clinical and radiological outcomes associated with the use of hydroxyapatite ( ha ) spacer and allogeneic bone ( ab ) spacer in laminoplasty.methodsfrom january 2006 to july 2014 , 79 patients with cervical spondylotic myelopathy or ossification of the posterior longitu... |
candida species are recognized as the 4th most common cause of nosocomial infections ( 1 ) .
candidiasis is considered to be responsible for more than 400 000 life - threatening infections worldwide every year .
the frequency and relative high mortality levels ( up to 45% for candida glabrata ) of these infections ... | we present the pathogenic yeast search for transcriptional regulators and consensus tracking ( pathoyeastract - http://pathoyeastract.org ) database , a tool for the analysis and prediction of transcription regulatory associations at the gene and genomic levels in the pathogenic yeasts candida albicans and c. glabrata ... |
autoimmmune polyendocrine syndrome type-2 ( aps-2 ) though being the most common polyendocrine disorder , is rare disease with a prevalence of 4 - 5/100,000 , predominantly occurring in females ( 3:1 ) with a peak onset in the fourth decade .
hypoparathyroidism as a part of polyglanduar syndrome is most commonly asso... | hypoparathyroidism is most commonly isolated and idiopathic .
hypoparathyroidism in autoimmune polyendocrine syndrome type-2 ( aps-2 ) is extremely rare with few isolated reports and usually presents late .
we present perhaps for the first time , hypoparathyroidism being the initial manifestation of aps-2 which was... |
young adults in college often discover the relationship between self - concept decline , emotional distress , depression , and anxiety .
in addition , a university student must adapt to a new society called a university to study .
it is also a time that female students pay attention to their appearance within their... | [ purpose]we obtained basic data on a proper weight loss training program by considering the relationship between body mass index ( bmi ) , the perception of appearance , and eating attitudes of korean female university students.[methods]the survey and anthropometry for the perception of appearance and eating attitudes... |
in 2013 , about 35.3 million people worldwide were estimated to be living with human immunodeficiency virus ( hiv ) .
seventy percent of these live in sub - saharan african countries . in east african countries like uganda , kenya , and tanzania ,
the prevalence in central african countries like cameroon and gabon ... | human immunodeficiency virus ( hiv ) infection is a common cause of chronic kidney disease ( ckd ) in sub - saharan africa .
this study aims at identifying the prevalence and predictors of ckd in newly diagnosed hiv patients in owerri , south east nigeria .
this was a cross - sectional study consisting of 393 newly... |
a periprosthetic humeral fracture is rare after shoulder arthroplasty , and such cases have considerable problems .
patients with this kind of fracture are often complicated by osteopenia , other types of severe disease , or are elderly .
surgical treatment of this fracture type carries some risk , and surgeons may... | introduction : a periprosthetic humeral fracture is rare after shoulder arthroplasty , and such cases have considerable problems . patients with this kind of fracture are often complicated by osteopenia , other types of severe disease , or are elderly .
surgical treatment of this fracture type carries some risk , and... |
aberrant dna methylation is one of the critical events in epigenetics and also plays an important role during tumorigenesis .
dna methylation at the fifth carbon ( 5-methylcytosine [ 5mc ] ) is a covalent biochemical modification , which mostly is located at the position of cytosine - phosphate - guanine ( cpg ) dinu... | objective : aberrant expression of ten - eleven translocation 1 ( tet1 ) plays a critical role in tumor development and progression .
we systematically summarized the latest research progress on the role and mechanisms of tet1 in cancer biology.data sources : relevant articles published in english from 1980 to april ... |
8-(4-chlorophenylthio ) 5-cyclic adenosine monophosphate acute myeloid leukemia all - trans retinoic acid breakpoint cluster region
abelson human recombinant granulocyte colony stimulating factor mitogen - activated protein kinase mammalian target of rapamycin nf - e2 related factor e2 promyelocytic leukemia retinoic... | p62 regulates key signaling pathways including those that control cell death and autophagy .
recently , we reported that p62 is upregulated during all - trans retinoic acid ( atra)-induced terminal differentiation of acute myeloid leukemia ( aml ) cells .
this response reduces levels of ubiquitinated protein aggreg... |
although glaucoma treatments have been developed , glaucoma is still a major cause of worldwide blindness .
trabeculectomy has long been performed as the only surgical procedure to achieve very low intraocular pressure ( iop ) to prevent progression of visual field damage in glaucoma eyes .
however , there is a ser... | purpose . to investigate clinical results on bleb - related endophthalmitis ( bre ) after trabeculectomy treated with pars plana vitrectomy ( ppv ) and to evaluate influence factors for visual prognosis
. methods . investigating medical records retrospectively
, bre was defined as an endophthalmitis induced by bleb... |
patients with clinical situations , such as skull defect , chronic non - unions of fracture , or spinal fusion may require repeated autologous bone grafts . the disadvantages of using autologous bone grafts include limited availability , donor - site morbidity , and reduced osteogenicity .
wright et al . have repaire... | backgroundthe major disadvantage of using a stem cell - based bone morphogenetic protein-4 ( bmp4 ) gene therapy for skull defect is the overgrowth of generated bone tissue in situ . in the present study , to overcome bony overgrowth of stem cell based - gene therapy , a new strategy of two - stage bone tissue engineer... |
presentation of dengue viral infection is often unpredictable , varying from clinically silent infection to uncomplicated dengue fever , dengue hemorrhagic fever , and severe fulminant dengue shock syndrome .
neurological manifestation in dengue hemorrhagic fever usually results from multisystem dysfunction secondary... | dengue is a common viral infection worldwide with presentation varying from clinically silent infection to dengue fever , dengue hemorrhagic fever , and severe fulminant dengue shock syndrome .
neurological manifestation usually results from multisystem dysfunction secondary to vascular leak .
presentation as hemor... |
the field of structure - based drug design relies on high - quality databases of protein ligand structures to develop the best computational tools .
there are several available , including but not limited to binding moad ( 1 ) , pdbbind ( 2 ) , lpdb ( 3 ) , relibase ( 4 ) , bindingdb ( 5 ) , pdblig ( 6 ) , msdsite (... | binding moad ( mother of all databases ) is a database of 9836 protein ligand crystal structures .
all biologically relevant ligands are annotated , and experimental binding - affinity data is reported when available .
binding moad has almost doubled in size since it was originally introduced in 2004 , demonstrati... |
copd is a comprehensive disease including chronic bronchitis and emphysema , and is characterized by the pathological limitation of airflow in the airway associated with chronic inflammation and alveolar destruction ( 1 ) .
it is one of major causes of morbidity and mortality throughout the world and projected to bec... | the molecular mechanisms involved in the pathogenesis of chronic obstructive pulmonary disease ( copd ) are poorly defined . accumulating evidences
indicate that chronic inflammatory responses and adaptive immunity play important roles in the development and progression of the disease .
recently , it has been shown... |
. often they are medically managed with intravenous antibiotics and catheter removal . in certain cases
we report a case of secondary hlh a hemodialysis patient secondary to persistent blood stream infection .
a 57-year - old man with chronic kidney disease due to diabetes , was admitted with progressive swelling o... | a 57-year - old man on dialysis presented with fever due to pseudomonas septicemia .
workup revealed very high triglycerides and serum ferritin levels .
a bone marrow examination showed hemophagocytosis .
a diagnosis of hemophagocytic lymphohistiocytosis ( hlh ) was made and steroids were started . he was put on ... |
adults aged 65 and older are the fastest growing age group in canada and other developed countries . in 2010 , 14.1% of the canadian population was 65 years and older ; that figure is projected to increase to 25.5% over the next 50 years .
the prevalence of alzheimer s disease ( ad ) and related forms of dementia is ... | purposeinformation about dementia is important for persons with dementia ( pwd ) and their caregivers and the internet has become the key source of health information .
we reviewed the content and quality of information provided on canadian websites for alzheimer s disease ( ad).methodswe used the terms dementia an... |
hypertension , defined as a systolic blood pressure 140 mmhg and/or a diastolic pressure 90 mmhg , is one of the most common chronic diseases .
the overall hypertension prevalence among the adult population was estimated at 26.4% in 2000 ; moreover it has been reported that this prevalence increased from 23.9% , in... | essential hypertension , a rise in blood pressure of undetermined cause , includes 90% of all hypertensive cases and is a highly important public health challenge that remains , however , a major modifiable cause of morbidity and mortality .
this review emphasizes that , from an evolutionary point of view , we are ad... |
dysfunction of glutamatergic transmission is involved in the pathogenesis of schizophrenia , neurodegenerative disorders , and addictions.15 pharmacological interventions in schizophrenia are currently focused on enhancing the activity of the n - methyl - d - aspartate ( nmda ) receptor , one of the subtypes of glutama... | glutamate is the main excitatory neurotransmitter in the central nervous system .
dysfunction of the glutamatergic system plays an important role in the pathogenesis of schizophrenia . therefore ,
glutamatergic agents such as n - methyl - d - aspartate receptor co - agonists ( ie , glycine , d - cycloserine ) and g... |
a 69-year - old man without underlying disease developed a productive cough 5 days before visiting chungbuk national university hospital .
he was prescribed cold medicine in a local clinic . the day before visiting our hospital , he had fever , chills , breathlessness , and pain in the right chest wall , and thus ... | mucormycosis is a fatal opportunistic fungal infection that typically occurs in immunocompromised patients .
the classical manifestation of mucormycosis is a rhinocerebral infection , and although primary gastrointestinal infection is uncommon , it has an extremely high mortality rate in immunocompromised patients . ... |
today , acid etching is the most common method of preparing enamel for bonding orthodontic brackets .
although this method results in high bond strength , its great disadvantage is the potential for caries formation .
acid etching removes and demineralizes the most superficial layer of enamel and makes the teeth mo... | background : several studies have shown that laser - etching of enamel for bonding orthodontic brackets could be an appropriate alternative for acid conditioning , since a potential advantage of laser could or might be caries prevention . this study compared enamel resistance to demineralization following etching with ... |
they are mixed tumors , consisting of both epithelial and mesenchymal cells , that present a complete dental tissue differentiation ( enamel , dentin , cementum , and pulp ) . according to the latest classification of the world health organization ( who , 2005 )
, two types of odontomas can be found : complex odontom... | odontomas are benign odontogenic tumors composed of enamel , dentine , and cementum and pulp tissue .
they are usually clinically asymptomatic , but often associated with tooth eruption disturbances .
the present study reports an unusual case of eleven odontomas in the left lateral incisor - canine region of lower ... |
the search for an ideal restoration led to the introduction of composite resins by bowen in 1962 and its continuous evolution since then to this present day .
a variety of composites , including conventional , microfilled , hybrid , flowable , packable , nanofilled have been introduced till date . though they have be... | aim : this in vitro study was carried out to compare the effect of led light curing system on polymerization and hardness of silorane - based and methacrylate - based posterior composite resin.materials and methods : a total of 40 samples , 20 of silorane - based composite filtek p-90 and 20 of methacrylate - based com... |
development and regeneration are processes driven by dynamic regulation of extracellular matrix ( ecm ) .
ecm is continuously exposed to physical and chemical injuries , and its composing proteins are continuously synthesized and secreted by fibroblasts , which play a central role in regulation of tissue homeostasis ... | lipocalin family members have been implicated in development , regeneration , and pathological processes , but their roles are unclear .
interestingly , these proteins are found abundant in the venom of the lonomia obliqua caterpillar .
lipocalins are -barrel proteins , which have three conserved motifs in their am... |
cutaneous squamous cell carcinoma ( scc ) is the second most common type of non - melanoma skin cancer .
management of patients with metastatic squamous cell skin cancer , refractory to initial therapy with standard chemotherapy and radiation protocols , remains difficult with poor overall prognosis and limited thera... | management of patients with metastatic squamous cell skin cancer , refractory to initial therapy with standard chemotherapy and radiation protocols , remains difficult with poor overall prognosis and limited therapeutic options .
recently , promising response rates with nivolumab , a programmed death receptor-1-block... |
chronic inflammatory demyelinating polyneuropathy ( cidp ) is a predominantly motor polyneuropathy of unknown aetiology .
his past medical history revealed cidp 20 years previously which was manifested by weakness and paraesthesia of all four limbs ( power 3/5 ) for the last 2 months .
haematological investigations... | a 60-year - old man with chronic inflammatory demyelinating polyneuropathy ( cidp ) was posted for surgery of the neck femur fracture and was successfully managed .
we discuss the anaesthetic considerations during regional and general anaesthesia of this patient with cidp .
a brief review of the available literatur... |
a bronchioloalveolar carcinoma ( bac ) pattern is defined as growth of neoplastic cells along preexisting alveolar structures ( lepidic growth ) .
although this pattern is a distinctive feature of bac that is noninvasive adenocarcinoma , invasive adenocarcinomas often contain areas of bac morphology at the tumor peri... | purposethis study was conducted in order to investigate the significance of transforming growth factor 1 ( tgf1 ) and e - cadherin proteins in tumor progression of lung adenocarcinoma and to evaluate their differential expression in association with morphologic characteristics.materials and methodsa total of 65 pulmona... |
the performance of dental restorations is influenced by several factors , including the restorative materials used , the clinician 's level of experience , the type of tooth , the tooth 's position in the dental arch , the restoration 's design , the restoration 's size , the number of restored surfaces , and the patie... | aim : to compare newer bulk - fill composites with an incrementally filled composite for adaptability and subsequent gap formation at the pulpal floor.materials and methods : class i cavities were prepared in 60 intact molars , with a shallow depression in the center of the pulpal floor .
the samples were divided int... |
verrucous hemangiomas are rare angiomatous nevi that are present at birth and grow into adulthood .
they usually involve the dermis with extension into subcutaneous plane and deserve deep excision to avoid recurrence .
magnetic resonance imaging ( mri ) has been used in soft tissue and musculoskeletal lesions : bot... | magnetic resonance imaging ( mri ) has established itself as diagnostic modality of choice of soft tissue and musculoskeletal lesions but dermatological lesions have been diagnosed mainly by clinical examination .
we present mri features of dermal and subcutaneous verrucous hemangioma involving the dorsum of foot in ... |
aggregates of c60 or c70 were synthesized and subsequently exposed to methane
inside of superfluid helium nanodroplets .
the nanodroplets were produced
by expanding helium from a stagnation pressure of approximately 2
mpa through a 5 m nozzle , cooled to about 8 k , into vacuum .
the average number of helium ... | bundles of single - walled nanotubes are promising candidates for
storage of hydrogen , methane , and other hydrogen - rich molecules , but
experiments are hindered by nonuniformity of the tubes .
we overcome
the problem by investigating methane adsorption on aggregates of fullerenes
containing up to six c60 ... |
multiple sclerosis ( ms ) is an autoimmune disease of the central nervous system ( cns ) that manifests as three subtypes , the most common being the relapsing - remitting ( rr ) which generally shifts to a
a third type is the primary progressive ( pp ) ms , characterized by a poor prognosis and usually managed wit... | multiple sclerosis ( ms ) is an autoimmune disease of the central nervous system and represents a major cause of disability in young adults .
nowadays , the dichotomy between demyelination and neurodegeneration has been challenged , and both processes are believed to occur independently early in the disease process .... |
prion fly stocks used in the original study were kindly provided by prof pj dolph ( dartmouth college hanover , usa ) with the help of archana murali .
the university of iowa developmental studies hybridoma bank ( dshb ) and prof hermann aberle , university of dsseldorf provided essential reagents for this project... | neurodegenerative disorders are characterized by synaptic and neuronal dysfunction which precedes general neuronal loss and subsequent cognitive or behavioral anomalies .
although the exact early cellular signaling mechanisms involved in neurodegenerative diseases are largely unknown , a view is emerging that comprom... |
frontotemporal lobar degeneration ( ftld ) is a clinically and pathologically diverse group of neurodegenerative diseases associated with focal frontal and temporal lobe atrophy.1 behavioural disturbances are common in ftld , most saliently in the canonical syndromes of behavioural variant frontotemporal dementia ( bvf... | impairments of face processing occur frequently in frontotemporal lobar degeneration ( ftld ) but the neuroanatomical basis for these deficits has seldom been studied systematically . here
a prospective voxel based morphometry study is described addressing the neuroanatomy of two key dimensions of face processing fa... |
tallahassee , fl , usa ) were set up on dry , arable lands or scrublands surrounding the cities of lusaka ( 152630.85s , 282651.09e ) , namwala ( 154301.37s , 264233.41e ) , and mfuwe ( 13647.92s , 314817.24e ) .
we captured 57 , 48 , and 158 rodents in each of these cities , respectively .
rodents were euthanized ... | to investigate arenavirus in zambia , we characterized virus from the kidneys of 5 arenavirus rna positive rodents ( mastomys natalensis ) among 263 captured .
full - genome sequences of the viruses suggested that they were new strains similar to lassa virus related arenaviruses . analyzing samples from additional ... |
focal segmental glomerulosclerosis ( fsgs ) is the most common primary glomerular disease leading to end - stage renal disease ( esrd ) .
the majority of cases ( 80% ) are idiopathic ; the remainder are associated with genetic mutations , viral infections , drugs or adaptive conditions such as obesity and sickle cell... | focal segmental glomerulosclerosis ( fsgs ) is a leading cause of end - stage renal disease and has a high recurrence rate after kidney transplantation , attributed to a circulating permeability factor .
plasmapheresis is the treatment of choice after recurrence to remove the circulating factor .
we present a case ... |
the study reported by harbarth and colleagues in the previous issue of critical care is the first clinical investigation to evaluate the impact of a novel molecular assay for rapid screening of methicillin - resistant staphylococcus aureus ( mrsa ) carriage in the intensive care setting .
the authors conducted a mult... | control strategies for methicillin - resistant staphylococcus aureus ( mrsa ) in critical care remain debated .
timely detection of mrsa carriers is crucial to an effective isolation policy . in this issue ,
harbarth and colleagues report rapid mrsa screening among intensive care unit - admitted patients using a pc... |
prostate - specific antigen ( psa ) level , tumor grade , and clinical stage determine the prognosis .
this disease has a wide spectrum ranging from the very low psa , low - grade impalpable disease to the very high psa , high grade locally advanced disease .
treatment too varies from active surveillance to radical... | introduction : prognosis of prostate cancer depends on the risk stratification .
damico classification , the most commonly used risk stratification method is based on three factors , i.e. , prostate specific antigen ( psa ) , gleason grade and clinical stage . the impact of presence of multiple risk factors on progno... |
maxillomandibular fusion can involve only the oral soft tissues or both hard and soft tissues .
it may present with aerodigestive problems and facial growth deformities from temporomandibular joint ankylosis at later stage .
congenital fusion of the maxilla and mandible mostly appears in association with other anat... | congenital fusion of jaw and its association with ankyloblepharon filiforme adnatum is reported but is a quite rare congenital benign anomaly .
it may be unilateral or bilateral and can present with a single system or multiple systems involvement .
this report concentrates on describing the clinical features of abo... |
allogeneic hematopoietic stem cell transplantation ( hsct ) is an established treatment of various haematological malignancies and certain congenital metabolic disorders .
the chance of finding a human leucocyte antigen- ( hla- ) identical donor - recipient pair amongst siblings is only one in four .
therefore , st... | while many hla class i molecules interact directly with the peptide loading complex ( plc ) for conventional loading of peptides certain class i molecules are able to present peptides in a way that circumvents the plc components .
we investigated micropolymorphisms at position 156 of hla - a*24 allotypes and their ef... |
in 1907 , james ramsay hunt first postulated that the etiology of herpes zoster oticus was the reactivation of the varicella zoster virus ( vzv ) in the geniculate ganglion ( 1 ) .
he described a variety of clinical manifestations of the syndrome that were ultimately named after him ( 2 ) .
although ramsay hunt syn... | objectivespure tone audiometry and caloric test in patients with herpes zoster oticus were performed to determine the biologic features of the varicella zoster virus ( vzv ) and the pathogenesis of vestibulocochlear nerve disease in herpes zoster oticus.study designa retrospective chart review of 160 patients with herp... |
recently , the chiron corporation announced the discontinuation of an international phase iii trial , which was designed to determine whether high dose intermittent interleukin-2 ( il2 ) therapy could improve on the clinical outcome of standard antiviral therapy for individuals infected with the human immunodeficiency ... | there is now effective therapy for infection by the human immunodeficiency virus ( hiv ) , but there is no cure .
consequently , antiviral drugs must be administered continuously to suppress viral replication .
recently , a large phase iii international immune - based therapy trial was discontinued because it is di... |
diabetes represents a spectrum of metabolic disorders , characterized by chronic hyperglycemia and disturbance in carbohydrates , fat , and protein metabolism resulting from defects in insulin secretion , insulin action , or both .
this disease affects 8.3% ( 366 million people ) of the world population in 20 - 79 ye... | background and objectives : gestational diabetes mellitus ( gdm ) is a global health concern as it affects health status of both mother and fetus . in india ,
prevalence of gdm varies in different populations and no data is available from rural haryana .
this study was undertaken to determine the prevalence of gdm ... |
rna molecules undergo extensive post - transcriptional modifications that are important for their biological activities .
a major category of post - transcriptional modifications is 2-o - ribose methylation of the backbone , which occurs frequently in ribosomal rna and often at positions that are conserved in evoluti... | natural rnas contain many base modifications that have specific biological functions .
the ability to functionally dissect individual modifications is facilitated by the identification and cloning of enzymes responsible for these modifications , but is hindered by the difficulty of isolating site - specifically modif... |
among primary hepatic tumors , the rate of the combined type of hepatocellular carcinoma and cholangiocarcinoma is approximately 1.06.3% , and the probability of double cancers found in different lobes of a liver is extremely rare .
furthermore , the cases of double hepatic cancer accompanying early gastric cancer ha... | combined hepatocellular carcinoma and cholangiocarcinoma is found at a frequency of 1.06.3% in resected primary hepatic tumors .
however , the case of double cancers of hepatocellular carcinoma and cholangiocarcinoma that are discovered synchronously in different lobes of a liver is very rare .
we experienced a cas... |
excessive alcohol consumption is the fourth leading preventable cause of death in the united states , causing 88,000 deaths and costing 223 billion dollars annually .
consumption is widespread , with over 90% of americans drinking alcoholic beverages at some point during their life . in small to moderate doses ,
ho... | alcoholism has a profound impact on millions of people throughout the world .
however , the ability to determine if a patient needs treatment is hindered by reliance on self - reporting and the clinician s capability to monitor the patient s response to treatment is challenged by the lack of reliable biomarkers . usi... |
a 49-year - old male visited jinjiang hospital of quanzhou medical college with the complaint of a painless mass in the right parietal - occipital region of the skull .
the mass was found incidentally 1 month earlier by the patient himself and it had grown rapidly .
he denied any head traumas or any significant med... | skull metastasis from hepatocellular carcinoma ( hcc ) is reported rarely . in addition
, solitary skull metastasis as the first symptom of hcc is reported even less . here , we reported a case of solitary skull metastasis as the first symptom of hcc and reviewed the literature on skull metastasis .
a 49-year - old... |
members of the genus actinomyces , originally classified as a fungus because of its branching characteristic , were first described in the early nineteenth century .
actinomyces meyeri , a gram positive anaerobic bacterium , is common inhabitant of the oral cavity and human pharynx region , rarely affecting long bone... | actinomyces meyeri is a gram positive , strict anaerobic bacterium , which was first described by meyer in 1911 .
primary actinomycotic osteomyelitis is rare and primarily affects the cervicofacial region , including mandible .
we present an unusual case of osteomyelitis of a long bone combined with myoabscess due ... |
increasing failure rate of dental local anesthetic injections especially in the mandibular molars is a continual challenge in dentistry .
supplemental injection techniques are essential to be used in cases where the conventional local anesthetic techniques have failed .
a study by meechan , reported that the inferi... | objective : to compare the injection pain and speed of local anesthetic effect induced by tissue infiltration of mepivacaine 2% with epinephrine 1:100,000 versus articaine 4% with epinephrine 1:100,000 in securing mandibular first molar pulp anesthesia.materials and methods : totally , 25 patients were recruited in a c... |
medical tourism patients traveling to foreign countries for medical procedures is an emerging phenomenon in the healthcare industry .
there are major reasons that cause people to get health care with international traveling including : long waiting lists in developed countries , low cost in developing countries , d... | introduction : policy makers and decision makers must identify the stakeholders in medical tourism , who will be affected by and/or affect this industry , and determine their status for partnership .
the aim of this study was to identify the main stakeholders in isfahan 's medical tourism , analyze them , and provide... |
case management has been defined as an administrative service that directs client movement through a series of phased involvements with the health and social service delivery system with the goal of increasing the quality and cost effectiveness of care ( capitman , haskins , and bernstein , 1986 ) .
case management (... | case management has developed as an administrative service for controlling costs and improving the quality of health and social service delivery .
long - term care case management combined with service expansion has been examined in some detail with varied results .
less research has focused on case management for ... |
angiomyolipoma , a form of mixed mesenchymal tumor , is a benign neoplasm composed of proliferated blood vessels , smooth muscle and fatty tissue with intermediate and immature cells .
it is a fairly common tumor of the kidney but rarely found in the mediastinum .
it can also occur in a sporadic form or be associat... | angiomyolipoma is a common tumor of the kidney but has rarely been found in the mediastinum .
we report a case of angiomyolipoma of the posterior mediastinum in a 62-year - old woman .
she experienced exertional dyspnea and intermittent cough at admission .
computed tomography indicated a tumor located at the lef... |
the preservation of health and freedom from pain and suffering caused by diseases has been one of the most important issues that have always occupied the human mind since ancient times .
a healthy environment includes clean water , healthy food , clean air , and proper disposal of sewage and garbage .
the means of ... | background : women and mothers are the most important educational audience to convey health teachings . this study was aimed to evaluate the knowledge level of different types of health violations of food production , distribution , sale centers and public places ; and authorities investigating the violations among wom... |
anxiety disorders are among the most common mental health conditions , which cause significant functional impairments , and frequently turn into chronic clinical conditions ( nutt et al .
recent epidemiological findings suggest them as the most frequent class of mental disorders with a high degree of comorbidity with... | anxiety disorders are the most common psychiatric disorders .
they are frequently treated with benzodiazepines , which are fast acting highly effective anxiolytic agents . however , their long - term use is impaired by tolerance development and abuse liability .
in contrast , antidepressants such as selective serot... |
dna microarray technology provides us a way to monitor the expression levels of thousands of genes simultaneously across a collection of related samples .
this technology has been applied particularly to the prediction of different types of human cancer with encouraging results .
support vector machines ( svm ) a... | dna microarrays provide rich profiles that are used in
cancer prediction considering the gene expression levels
across a collection of related samples .
support vector machines
( svm ) have been applied to the classification of cancer
samples with encouraging results .
however , they rely on
euclidean dis... |
let us first examine when the crop farming began before inquiring the origin of cooked rice , our staple food .
it has been 4 - 5 million years since the human race existed on earth as homo erectus , and farming has been thought as the motive power for entering into the production economy with stabilized food supply ... | cooked rice is a staple food for koreans which provides more than 60% of daily required energy . in 1960 's ,
koreans ate 600 g-800 g of cooked rice per meal and the energy obtained from cooked rice was almost more than 80% of the daily intake of energy .
however , as the economy of korea improved , the major indus... |
solution ph is considered to be a master descriptive variable for
characterization of chemical , biological , and biogeochemical systems .
measurements of ph facilitate characterizations of acid / base equilibria ,
primary production / respiration , mineral saturation states , and the
status of the carbon dioxi... | this work examines the use of purified meta - cresol purple ( mcp )
for direct spectrophotometric calibration of glass ph electrodes in
seawater .
the procedures used in this investigation allow for simple ,
inexpensive electrode calibrations over salinities of 2040
and temperatures of 278.15308.15 k without ... |
the value of plants has a long history in saving human beings cutting across different cultures in the world .
utilization of medicinal plants by individuals lies on the knowledge accumulated through the interaction of people with the environment and the diffusion of information , traditionally transmitted orally thr... | background / aim : some of the antifungal drugs used in the current treatments regime are responding to antimicrobial resistance . in rural areas of southern tanzania ,
indigenous people use antifungal drugs alone or together with medicinal plants to curb the effects of antibiotic resistance .
this study documented... |
stress - responsive signaling pathways often mediate adaptive changes that favor microbial survival and propagation of the infection .
therefore , many investigators have attempted to define microbial signaling pathways activated in response to the host .
one of these pathways , the cyclic amp ( camp)/protein kinas... | abstractthe protein kinase a ( pka ) signal transduction pathway has been associated with pathogenesis in many fungal species . geddes and colleagues [ mbio 7(1):e01862 - 15 , 2016 , doi:10.1128/mbio.01862 - 15 ] used quantitative proteomics approaches to define proteins with altered abundance during protein kinase a (... |
idiopathic hirsutism ( ih ) is defined as the presence of excessive terminal hair in androgen - dependent areas of a woman 's body in conjunction with normal ovulatory function and normal serum androgen levels .
however , an increased sensitivity of the pilosebaceous unit to circulating androgens , due to increased p... | aim : many psychiatric disorders , including attention - deficit / hyperactivity disorder ( adhd ) , disruptive behavioral disorders , autism spectrum disorders , and some psychiatric characteristics , such as poor empathizing , are regarded to be related to elevated levels of androgens or androgen sensitivity . thus ,... |
the cichlid fish in east african lakes are emerging as one of the potentially most powerful model systems in speciation and adaptive radiation research [ 14 ] .
the rock - dwelling communities of these lakes comprise several species complexes or genera that can be strongly differentiated in ecology .
by contrast , ... | it has been suggested that intrasexual competition can be a source of negative frequency - dependent selection , causing agonistic character displacement and facilitating speciation and coexistence of ( sibling ) species . in this paper
we synthesise the evidence that male - male and female - female competition contr... |
since 2010 , age - stratified serum sample collections have been ongoing in the hospital for tropical diseases in ho chi minh city , vietnam , and in khanh hoa provincial hospital in nha trang , 300 km northeast of ho chi minh city . ho chi minh city is a densely populated major urban center with an official population... | there are no contemporary data available describing human immunity to novel influenza a / h7n9 . using 1723
prospectively collected serum samples in southern vietnam , we tested for antibodies to 5 avian influenza virus antigens , using a protein microarray .
general - population antibody titers against subtype h7 ... |
schizophrenia is a major mental illness that causes changes in perception , thoughts and behavior .
researchers found poor insight to be a prevalent feature of schizophrenia , as well as an important discriminating factor . international pilot study for schizophrenia ( ipss ) ( who , 1973 ) revealed that 85% of the s... | background : lack of insight or awareness of illness is most frequently observed in patients with schizophrenia , and it influences treatment compliance .
it has been hypothesized that the frontal dysfunction may explain poor insight in schizophrenia.aim:the purposes of the study were to assess the degree of insight ... |
there is currently a high demand for neuropsychiatric brain banks to support neurobiological research with post - mortem tissue obtained from psychiatric patients with schizophrenia , bipolar disorder and depression .
based on a comprehensive literature search , we identified brain regions such as the hippocampus , p... | it is widely accepted that neurobiological abnormalities underlie the symptoms of psychiatric disorders such as schizophrenia and unipolar or bipolar affective disorders .
new molecular methods , computer - assisted quantification techniques and neurobiological investigation methods that can be applied to the human b... |
capecitabine ( xeloda ) is an oral fluoropyrimidine carbamate , which is converted to its only active metabolite , fu , by thymidine phosphorylase .
higher levels of this enzyme are found in several tumors , as well as the liver , compared with normal healthy tissue1 - 3 ) .
the localization of this enzyme to liver... | hand - foot syndrome ( hfs ) is a well - known adverse event associated with capecitabine , a prodrug of 5-fluorouracil ( 5-fu ) .
hfs manifests as acral erythema , with swelling and dysesthesia of the palms and plantar aspects of the feet , which in the absence of dosage reduction or drug cessation , progresses to m... |
a prospective study was undertaken following the tenets of the declaration of helsinki to investigate the results of teller visual acuity and snu dot visual acuity tests .
approval from the ethics committee for human studies of seoul national university hospital clinical research institute was granted for the study .... | purposeto investigate the efficacy of a computerized visual acuity test , the snu visual acuity test for children.methodsfifty-six children , ranging from 1 to 5 years of age , were included . in a dark room , children gazed at and followed a circular dot with 50% contrast moving at a fixed velocity of 10 pixels / sec ... |
immortalized hmgecs were grown in keratinocyte serum - free medium ( life technologies , grand island , ny , usa ) , as previously described .
cells were treated with three doses of cya , utp , rebamipide , bimatoprost ( all purchased from santa cruz biotechnology , dallas , tx , usa ) , or recombinant human il-1ra (... | purposeresearchers have hypothesized that treatment with cyclosporine a ( cya ) , interleukin-1 receptor antagonists ( il-1ra ; e.g. , anakinra ) , p2y2 receptor agonists ( e.g. , uridine triphosphate ; utp ) , and rebamipide may alleviate human meibomian gland dysfunction ( mgd ) and/or dry eye disease .
investigato... |
spindle - cell hemangioendothelioma ( sche ) is a rare vascular tumor that was first described in 1986 by sharon weiss .
sche commonly starts at childhood or young adult though the tumor may affect all the age group .
clinically , the tumor presents as a superficially located firm red to brown nodules on the distal... | spindle - cell hemangioendothelioma ( sche ) comprise a rare subset of vascular tumors , and here , we describe such a case and review the clinical presentation , patho - physiology , differential diagnosis of these tumors to promote early identification and discussion guidance . a 25-years - old male patient presented... |
focal cortical dysplasia ( fcd ) is the most commonly encountered developmental malformation causing refractory epilepsy .
malformation of cortical development ( mcd ) is malformative lesions of the brain resulting from developmental aberration of normal processes that take place mostly during the first two trimester... | focal cortical dysplasia ( fcd ) is the most commonly encountered developmental malformation that causes refractory epilepsy . with advances in neuroimaging techniques , in particular mri ,
recent studies have revealed a higher prevalence of fcd than previously estimated and have improved the preoperative identificat... |
undescended testis or cryptorchidism is a common anomaly encountered in paediatric urology and is estimated to affect 1 to 4 per cent of full term and up to 30 per cent of preterm male neonates1 .
ever since the first description of this condition by hunter in 17861 , a lot of research has been done to understand the... | cryptorchidism or undescended testis is one of the most common anomalies encountered in paediatric urology and is estimated to affect 1 to 4 per cent of full term and upto 30 per cent of preterm male neonates .
the associated problems of sub - fertility or infertility and malignant transformation have been recognized... |
all patients in the study were hospitalized on our unit with a confirmed diagnosis of sars .
samples from patients included plasma , throat swab , sputum , and stool ; these were stored at 70c for extraction of viral rna .
a total of 64 rna samples from 28 sars - cov positive patients ( detected by using bni prime... | to characterize genetic variation of severe acute respiratory syndrome associated coronavirus ( sars - cov ) transmitted in the beijing area during the epidemic outbreak of 2003 , we sequenced 29 full - length s genes of sars - cov from 20 hospitalized sars patients on our unit , the beijing 302 hospital .
viral rna... |
vitamin d is recognized to be an essential element for bone metabolism and skeletal health ; however , its deficiency can cause rickets in children as well as an increased propensity for osteoporosis .
indeed , vitamin d deficiency has been identified as a risk factor for diabetes mellitus [ 2 , 3 ] , cancers , multi... | background .
a recent study has reported that high circulating 25-hydroxyvitamin d [ 25(oh)d ] is associated with low circulating thyroid - stimulating hormone ( tsh ) levels , but only in younger individuals .
the goal of the present study was to explore the relationship between vitamin d status and circulating ts... |
bacterial bloodstream infections ( bsi ) account for considerable morbidity worldwide , but epidemiological data from resource - constrained tropical settings are scarce .
we analysed 293 blood cultures from patients presenting to a regional referral hospital in bouak , central cte divoire , to determine the aetiolog... | |
this study is a retrospective chart review of six consecutive cases ( six eyes ) of microbiologically proven postoperative fungal endophthalmitis presenting to a tertiary care center in north india who presented with multiple recurrences .
our center serves as a tertiary eye - care referral hospital for a greater par... | aim : to report the management of recurrent postoperative fungal endophthalmitis ( pofe ) after failed pars plana vitrectomy ( ppv ) and antifungal therapy.settings and design : tertiary care referral centre in north india .
retrospective , single institution , interventional case-series.materials and methods : six p... |
in an ongoing , prospective study of clinical rickettsial disease in the tidewater region of virginia and jacksonville , florida , one of the primary objectives is to identify the prevalence of r. parkeri infection among persons seeking care with tick bite eschars or who have received a clinical diagnosis of rickettsia... | the typical clinical presentation of several spotted fever group rickettsia infections includes eschars . clinical diagnosis of the condition is usually made by analysis of blood samples .
we describe a more sensitive , noninvasive means of obtaining a sample for diagnosis by using an eschar swab specimen from patien... |
prostate cancer ( pca ) is one of the most common cancers among men over 50 years old and is the sixth leading cause of cancer - related deaths world - wide .
although its incidence is higher in developed countries than in developing counties , it is still increasing in developing areas [ 35 ] .
currently , the dia... | backgroundthe present study aimed to compare the expression of liver kinase b1 ( lkb1 ) in prostate cancer ( pca ) tissues and the paired adjacent tissues , then to evaluate the statistical relationship between lkb1 expression and prognosis of pca patients.material/methodsthe relative expression of lkb1 at mrna level w... |
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