Subset (2)

section · 133k rows

Split (3)

train · 120k rows

article stringlengths 0 826k	abstract stringlengths 174 4.34k
delayed cerebral ischemia ( dci ) is a major cause of poor outcome after subarachnoid hemorrhage ( sah ) . although cerebral vasospasm has been indicated as the main cause of dci , vasospasm and dci do not always go hand in hand , which shows that vasospasm is not the only or essential factor for the development of d...	the pathogenesis of secondary infarctions ( si ) after aneurysmal subarachnoid hemorrhage ( sah ) is poorly understood . to assess whether si in single ( ssi ) or multiple ( msi ) vascular territories represent different disease entities , we compared clinical profiles of patients with these patterns of si . ct / mri...
neurocristic cutaneous hamartoma ( nch ) of the scalp , a rare lesion , presumably results from aberrant development of neuromesenchyme . its elements reflect the spectrum of differentiation inherent in neural crest - derived cells . to our knowledge , in the english literature , very few examples of nch have been ...	neurocristic cutaneous hamartoma of the scalp , a rare entity , may be either congenital or acquired . the former must be distinguished from other forms of congenital nodular and plaque - like lesions such as giant congenital nevi , common and cellular blue nevi , and melanoma . we describe the clinicopathologic fe...
the inflammatory bowel diseases ( ibds ) are a heterogeneous group of disorders which have two major phenotypic forms , crohn 's disease and ulcerative colitis , characterized by chronic relapsing and remitting intestinal inflammation 14 . ulcerative colitis is the most common of the ibds 5 and is characterized by a ...	dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease ( ibd ) pathogenesis . dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regula...
type of study and population sample - in this cross - sectional observational study , the total sample was subdivided into two groups : patients affected by leprosy reactions during or after treatment and patients without leprosy reactions at any time . the sample consisted of 440 leprosy patients diagnosed by a co...	this cross - sectional retrospective study evaluated 440 leprosy patients ; 57% ( 251/440 ) had leprosy reactions during and/or after multidrug therapy , 80.5% ( 202/251 ) of whom presented with multibacillary leprosy . at diagnosis , positive bacterial index ( bi ) [ odds ratio ( or ) = 6.39 ; 95% confidence interva...
despite major advances in perinatal care , the rate of preterm birth increased by 22% between 1991 and 2011 in australia , where more than 25,000 babies are now delivered preterm each year.1 preterm birth is well recognized as a major cause of adverse neonatal and childhood outcomes , affecting not only survival in the...	backgroundpreterm birth is a common cause of adverse neonatal and childhood outcomes , in both the short and long term . preterm labor is commonly associated with inflammation at the maternal fetal interface . there is some indirect evidence that mast cells ( mcs ) might represent a link between hormonal influence...
many mechanisms are proposed to lead to chronic inflammation of the gut mucosa , which is exemplified by crohn 's disease ( cd ) and ulcerative colitis ( uc ) , also known as inflammatory bowel diseases ( ibds ) . these include dysregulation of the innate immune response to enteric flora [ 2 , 3 ] , increased epithel...	cd73 is a glycosyl - phosphatidylinositol-(gpi- ) linked membrane protein that catalyzes the extracellular dephosphorylation of adenosine monophosphate ( amp ) to adenosine . adenosine is a negative regulator of inflammation and prevents excessive cellular damage . we investigated the role of extracellular adenosin...
different models , such as logistic and modified gompertz equations [ 1 , 2 ] and the monod model [ 36 ] have been widely used to describe the growth of different microorganisms in batch cultures . on the other hand , the classical luedeking and piret expression has been used to describe the time course of the prod...	the influence of initial ph on growth and nutrient ( total sugars , nitrogen , and phosphorous ) consumption by enterococcus faecium cect 410 was studied during batch cultures in whey . with these data , two realkalized fed - batch fermentations were developed using different feeding substrates . the shift from hom...
a 25-year - old female presented with a painless mass in the medial canthal area of the left eye . an examination revealed a hard , non - tender , movable mass measuring about 1 cm located just inferior to the left medial canthal tendon ( mct ) . the size of the mass did n't change when the patient 's position chan...	dermoid tumors in the medial canthal area are rare , but when present they commonly adhere to the lacrimal canaliculi . three patients presented with a mass in the medial canthal area . the authors performed excisional biopsies , and the masses were diagnosed as dermoid tumors . in two patients , canalicular lacera...
an extremely rare but life - threatening complication of anticoagulation with warfarin is hemorrhage into the soft tissues of the airway . we report a case of spontaneous hemorrhage into the epiglottis secondary to supratherapeutic anticoagulation with warfarin . a 37-year - old male with a history of factor v leid...	hemorrhage into the soft tissues of the airway represents a potentially life - threatening complication of long - term anticoagulation . we report the case of a chronically anticoagulated 37-year - old male who developed a spontaneous hematoma of the epiglottis secondary to a supra - therapeutic inr . epiglottic he...
cytokines underlie the clinical manifestations of many pathological and clinical syndromes ranging from shock and severe sepsis to arthritis and inflammatory bowel disease . the cytokine theory of disease originated in the 1970s and 80s and stemmed from basic biological and physiological studies of body weight , te...	the cholinergic antiinflammatory pathway is a neural mechanism that is controlled by the vagus nerve and inhibits local cytokine release , thereby preventing the damaging effects of cytokine overproduction . a new study now shows that dietary fat can activate this pathway , a finding that may help explain the immune ...
reactions to stings by hymenoptera species ( apis mellifera and vespula species ) are classified as normal local reactions , large local reactions ( llrs ) , systemic anaphylactic reactions ( sars ) , systemic toxic reactions , and unusual reactions .all patients who have had an sar to hymenoptera stings should avoid i...	background and objective . various venom immunotherapy ( vit ) protocols are available for hymenoptera allergy . although adverse reactions ( adrs ) to vit are widely reported , controlled trials are still needed . we conducted a randomized prospective study to evaluate adrs and the efficacy of three vit regimens...
the evaluation of the upper airway obstruction is important for head and neck angioedema.glossomegaly with decreased attenuation is common in head and neck angioedema.angioedema of the visceral organs can be multifocal and asymmetric.angioedema of the visceral organs is often accompanied by adjacent fluid.it is importa...	objectivesthe purpose of this pictorial review is to present imaging findings of angioedema involving the various organs.conclusionthe role of imaging for patients with angioedema includes the evaluation of the upper airway for obstruction and the exclusion of other possible aetiologies , such as neoplastic or infectio...
as many as 62% low back pain patients can have sacroiliac joint ( sij ) pain as diagnosed with analgesic efficacy of invasive diagnostic pain intervention / injection ( fair to good evidence ) . however , there is limited evidence for the diagnosis of sij pain by noninvasive tests . moreover , there is limited ( to...	as many as 62% low back pain patients can have sacroiliac joint ( sij ) pain . there is limited ( to poor ) evidence in regards to long - term pain relief with therapeutic intra - articular injections and/or conventional ( heat or pulsed ) radiofrequency ablations ( rfas ) for sij pain . we report our pain - clinic...
as long as the taste has no negative consequences , a learning process called habituation of neophobia takes place , leading to increased consumption when the taste is recognized as safe . safe taste memory in the rat has been proposed as a model of recognition memory useful for studies of the molecular substrates of...	interactions between glur2 and n - ethylmaleimide - sensitive factor ( nsf ) mediate ampa receptors trafficking . this might be linked with molecular mechanisms related with memory formation . previous research has shown basolateral amygdala ( bla ) dependent activity changes in the perirhinal cortex ( prh ) during...
who has declared leishmaniasis as one of most serious parasitic diseases and a public health problem in many countries worldwide ( 1 , 2 ) . it is responsible for high morbidity and mortality in developing countries and the number of human cases have increased during the past decade ( 3 , 4 ) . on the other hand , do...	toxicity and drug resistance against pentavalent antimonials , medications of choice in treatment of leishmaniasis for more than 5 decades , have become important subjects globally.this study was a randomized , open labeled trial that was designed to determine efficacy and safety of imod as a novel herbal immunomodulat...
in many classes of opioid compounds , small changes in structure modify the extent to which the opioid ligand exhibits agonist and/or antagonist properties . in the morphine family and in fused - ring opioids such as the 4,5-epoxymorphinon-3-one , morphinan , benzomorphan , and isoquinoline series , n - subst...	n - substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines ( 2a , b ) are opioid receptor antagonists where the antagonist properties are not due to the type of n - substituent . in order to gain a better understanding of the contribution that the 3- and 4-methyl groups make to the pure antagonist proper...
postpartum hemorrhage ( pph ) is a globally prevalent obstetric complication that is significantly associated with maternal mortality rates in developing countries.1 in turn , high pph rates are associated with the barriers to health care access typically faced by women in developing countries during pregnancy , childb...	backgroundby analyzing the perspectives of village health worker / trainers with the comprehensive rural health project ( crhp ) , this study aimed to investigate their level of knowledge of treatment , risks , and prevention of complications of labor and delivery and to evaluate current teaching methods.methodsthree f...
however , inguino - scrotal herniation of the ureter , also described as uretero - inguinal hernia , is a rare presentation . this presentation can potentially cause obstructive uropathy or serious surgical complications to the ureter during surgery if unrecognized . uretero - inguinal hernia in patients with nativ...	uretero - inguinal hernia in patients with native kidneys is rare . we report a case of an 84-year - old man who was diagnosed with obstructive uropathy secondary to uretero - inguinal hernia , with no past history of herniorrhaphy or congenital genitourinary malformation . uretero - inguinal hernias are predominan...
one of the greatest goals of biology is the reconstruction of the tree of life . recent advances in high - throughput sequencing technologies have seen an exponential increase in the amount of publicly available genomic data . the huge increase in genomic data requires us to develop efficient high - throughput meth...	with the number of fully sequenced genomes increasing steadily , there is greater interest in performing large - scale phylogenomic analyses from large numbers of individual gene families . maximum likelihood ( ml ) has been shown repeatedly to be one of the most accurate methods for phylogenetic construction . rec...
data collection was carried out from march to may 2008 at the university of agder , kristiansand , norway . this project ( ref : s-0627a , 2008/1851 ) was part of an intervention study with folic acid supplementation for 2 weeks , where the participants were given 800 g / folic acid per d in a double - blind c...	the association between diet and cvd can not be assigned to a single nutrient , but rather to a set of nutrients and non - nutrients , and eating pattern analyses have become an important tool in investigation of this relationship . our objective was to investigate eating patterns in relation to nutrient intake a...
it is well established that prostaglandins ( pgs ) protect the gastroduodenal mucosa against physiologic [ gastric acid and pepsin ] and non - physiologic irritants ( 1 ) . the involved mechanisms by which pgs maintain the integrity of gastric mucosa are decreasing the gastric acid output and increasing the mucus and...	objective(s):prostaglandins have been shown to mediate the gastro - protective effect of sodium hydrosulfide ( nahs ) but effect of nahs on mrna expression of prostaglandin e2 receptors ( ep1 , 3 - 4 ; eps ) has not been investigated . therefore , this study designed to evaluate the effect of nahs on mrna expression ...
impaired cognitive function is emerging as one of the greatest health threats of the twenty - first century . as the life expectancy of the population has increased so too has the prevalence of cognitive decline ( cod ) and dementia , largely in the form of alzheimer 's disease , which now affects almost 50% of adult...	objectives . we aimed to test the hypothesis that metabolic syndrome ( mets ) is significantly associated with cognitive decline ( cod ) in elderly adults and further assess whether mets and inflammation have a significant joint effect on cod . methods . data ( n = 2975 ) from the u.s . national health and nutrition ...
a 58-year - old man had been diagnosed with css from bronchial asthma , eosinophilia , polyneuropathy , and infiltration in lungs 2 years before . bilateral foot drop and hypereosinophilia developed 2 weeks before the present condition and he was treated with oral prednisolone ( 15 mg / day ) . on referral to the dep...	here we report a case of churg strauss syndrome ( css ) and central retinal artery occlusion ( crao ) , with good visual recovery . a 58-year - old japanese man with css experienced acute painless loss of vision in his right eye . crao was diagnosed by fundoscopic findings ( retinal whitening with a cherry - red sp...
west nile virus ( wnv ) is a member of the flaviviridae , which are enveloped , positive - stranded rna viruses . this family includes several globally important emerging arthropod - borne viruses that cause neuroinvasive disease in humans such as japanese encephalitis virus , tick - borne encephalitis , and wnv . ...	the recent introduction of highly pathogenic strains of west nile virus ( wnv ) into nave populations in europe , israel , and the usa has resulted in a marked increase in both the number of reported cases and the severity of disease compared to previous outbreaks . the impact of the increased virulence of recently e...
as early - stage tumor detection is a prognostic key factor when curing breast cancer , the prevailing driving force in emerging screening technologies is the ability to identify increasingly smaller tumors during the initial nonpalpable phase of the disease . conventional imaging modalities like x - ray mammography ...	microwave breast cancer detection is based on the dielectric contrast between healthy and malignant tissue . this radar - based imaging method involves illumination of the breast with an ultra - wideband pulse . detection of tumors within the breast is achieved by some selected focusing technique . image ...
intraoperative autologous transfusions have been used over the past 20 years as a means to avoid giving patients blood products from other individuals because of the risk of transfusion - related infections such as hepatitis and hiv . the incidence of hepatitis b and hepatitis c per unit of blood is estimated at 1 in...	intraoperative autologous transfusions have been used for many years to avoid transmission of infections , especially in vascular surgery , where blood usage is considerable . several autotransfusion devices exist , but these devices are often associated with negative outcomes such as cost , contamination , and remov...
in patients with severe optic nerve damage , it is crucial to prevent the hypertensive phase that can develop after baerveldt glaucoma drainage implant ( bgi ) surgery . we describe the combination of bgi surgery with surgical bleb revision to prevent the postoperative hypertensive phase . the combined surgery was ...	backgroundin patients with severe optic nerve damage , it is crucial to prevent the hypertensive phase that can develop after baerveldt glaucoma drainage implant ( bgi ) surgery . we describe the combination of bgi surgery with surgical bleb revision to prevent the postoperative hypertensive phase.case reportswe repo...
nonsmall cell lung cancers ( nsclc ) harboring mutations in the tyrosine kinase domain of the epidermal growth factor receptor ( egfr ) are well - studied examples of oncogene addiction . activating mutations , most commonly the point mutation l858r or deletions within exon 19 ( e.g. , residues 746750 ) , inc...	activating mutations within the epidermal growth factor receptor ( egfr ) kinase domain , commonly l858r or deletions within exon 19 , increase egfr - driven cell proliferation and survival and are correlated with impressive responses to the egfr inhibitors erlotinib and gefitinib in nonsmall cell lung cancer...
in healthy subjects , euglycemic hyperinsulinemia and carbohydrate - rich meals increase skeletal muscle blood flow through insulin receptor signaling and activation of endothelial nitric - oxide synthase . this response leads to an increase in capillary blood volume ( cbv ) and a higher functional capillary surface ...	the inability to augment capillary blood volume ( cbv ) in response to insulin or glucose is thought to contribute to insulin resistance ( ir ) by limiting glucose uptake in key storage sites . understanding the mechanisms that contribute to impaired cbv augmentation early in the onset of ir may lead to new future th...
in an experimental study performed in piglets with oleic - acid - induced lung injury , carvalho and coworkers provide evidence that high positive end - expiratory pressure ( peep ) is associated with alveolar recruitment and lung hyperinflation despite the administration of a low tidal volume ( tv ) . in addition , ...	in patients with acute respiratory distress syndrome , positive end - expiratory pressure is associated with alveolar recruitment and lung hyperinflation despite the administration of a low tidal volume . the best positive end - expiratory pressure should correspond to the best compromise between recruitment and dist...
throughout the short history of cardiac surgery , which is just over 100 years , surgeons worldwide have been determined to develop , perform , perfect , and improve cardiac operations . our forefathers set the bar high by performing magnificent cardiac operations with excellent long - lasting results . in this ever...	the specialty of cardiac surgery has evolved substantially over the last 50 years , and surgical procedures that seemed impossible then are now commonly encountered in hospitals throughout the world . the latest development in this ever - evolving field is minimally invasive and robot - assisted procedures . in this...
according to the world health organization ( who ) , odontogenic myxoma is classified as an odontogenic tumor of the ectomesenchymal origin . the mandible is involved more frequently than the maxilla , and most reports show a slight predilection for females . therefore , it reaches considerable size before being de...	odontogenic myxoma ( om ) is a rare and locally invasive benign neoplasm found exclusively in the maxillofacial region . the radiographic and clinical features are variable , and the diagnosis is therefore not easy . a case of om of the maxilla is described in a 19-year - old female , previously diagnosed as inflamma...
legionnaires disease ( ld ) is usually acquired through inhalation of aerosolized water contaminated with legionella spp . , which is found ubiquitously in natural and man - made aqueous environments such as cooling towers , hot water systems or whirlpools . legionella pneumophila , especially serogroup 1 ( sg1 ) ,...	in france , approximately 1200 cases of legionnaires disease ( ld ) are reported annually , and isolates are available for approximately 20% of cases identified since 2000 . all legionella pneumophila serogroup 1 ( sg1 ) isolates are characterized by sequence - based typing at the national reference centre . ld cas...
diabetic muscle infarction ( dminf ) is a rare microangiopathic complication in patients with advanced diabetes mellitus ( dm ) . patients having terminal diabetic nephropathy are prone to develop dminf and nearly one - fourth of dminf , patients receive renal replacement treatment . a 27-year - old woman with cyst...	diabetic muscle infarction is a rare microangiopathic complication occurring in patients with advanced diabetes mellitus . diabetic patients with chronic kidney disease stage vd are prone to develop this complication . the presenting symptom is a localized painful swelling of the affected limb . symptoms usually re...
live cells are protected from the surrounding environment by the cell membrane , which only allows compounds with a small molecular size to pass this barrier into the cell . some drug molecules , on the other hand , are large hydrophilic molecules , and this creates major limitations for their penetration through the...	detergent - mediated reconstitution of bacteriorhodopsin ( br ) into large unilamellar vesicles ( luvs ) was investigated , and the effects were carefully characterized for every step of the procedure . luvs were prepared by the extrusion method , and their size and stability were examined by dynamic light scattering...
sex cord tumor with annular tubules ( sctat ) is an infrequent malignant ovarian tumor in children . the predominant component of which has morphologic features intermediate between those of the granulosa cell tumor and those of the sertoli cell tumor . small cell carcinoma of the ovary of the hypercalcemia type ( ...	sex cord tumors with annular tubules are known to originate from the sex cord of embryonic gonads that synthesize sertoli cells , leydig cells , granulosa cells , and theca cells of the ovarian stroma , while ovarian small cell carcinoma of the hypercalcemic type is a type of neuroendocrine tumor . both these tumors ...
cardiopulmonary resuscitation ( cpr ) has been widely practiced since the clinical utilization of closed chest massage was first reported in 1960 . studies from the 1990s have noted hospital cpr discharge rates ranging from 13 to 14% . using data from 14,720 in - hospital cardiac arrests in the national registry of c...	despite efforts to save more people suffering from in - hospital cardiac arrest , rates of survival after in - hospital cardiopulmonary resuscitation ( cpr ) are no better today than they were more than a decade ago . this study was undertaken to assess the demographics , clinical parameters and outcomes of patients ...
the motor unit ( which contains a spinal motor neuron , its axon , and the muscle fibers it innervates ) is the final common pathway for neuromuscular control and provides a basic structure - function framework for neuromuscular system examination . motor unit plasticity refers to motor unit adaptation or the ability...	decomposition of electromyograms ( emg ) is a key approach to investigating motor unit plasticity . various signal processing techniques have been developed for high density surface emg decomposition , among which the convolution kernel compensation ( ckc ) has achieved high decomposition yield with extensive validat...
the development of antineoplastic agents with novel molecular targets opens the door to new , potentially valuable treatment strategies . we previously reported the effect of difluorinated n , n-dialkylaminostilbenes ( fidas agents ) on the proliferation of colon and liver cancer cells . we identified ( e)-...	inhibition of the catalytic subunit of the heterodimeric methionine s - adenosyl transferase-2 ( mat2a ) with fluorinated n , n - dialkylaminostilbenes ( fidas agents ) offers a potential avenue for the treatment of liver and colorectal cancers where upregulation of this enzyme occurs . a study of structure ...
the gold standard treatment for nonmetastatic muscle - invasive and bacille calmette - guerin ( bcg)-refractory , high - risk nonmuscle invasive bladder cancer ( bc ) is open radical cystectomy ( orc ) with pelvic lymph node dissection ( plnd ) . orc with urinary diversion , however , remains a morbid operation with ...	purposerobot - assisted radical cystectomy ( rarc ) was originally intended to replace open radical cystectomy ( orc ) as a minimally invasive surgery for patients with invasive bladder cancer . the purpose of this study was to evaluate the advantages of robotic surgery , comparing perioperative and oncologic outcome...
participants were recruited from the university of exeter and the local area using e - mails and newspaper advertisements . one hundred thirtynine persons ( 100 women ) consented to take part ( range = 1867 years , m = 26.8 years old , sd = 13.3 ) . data from a subset of these participants examining the direct rela...	models of self - regulation propose that negative affect is generated when progress towards goals is perceived to be inadequate . similarly , ruminative thinking is hypothesised to be triggered by unattained goals ( martin & tesser , 1996 ) . we conducted an experience - sampling study in which participants recorde...
animals prefer an immediate reward over a delayed reward even when the delayed reward is more economically valuable in the long run . in the lab , the neural mechanisms underlying this aspect of decision - making are often studied in tasks that ask animals or humans to choose between a small reward delivered immediat...	a number of factors influence an animal s economic decisions . two most commonly studied are the magnitude of and delay to reward . to investigate how these factors are represented in the firing rates of single neurons , we devised a behavioral task that independently manipulated the expected delay to and size of rew...
in the last decade increasing numbers of clostridium difficile infections ( cdi ) have been reported in northern america and europe . similarly in germany an increased number of cdi affected inpatients was observed between 2000 and 2004 . a previous study reported that the number of c. difficile toxin ( tcd)-positi...	summarybetween 2000 and 2009 , the total number of patients with clostridium difficile infections increased considerably in southeastern germany . a clear seasonality was observed with a higher number of affected patients occurring in the winter months ( january march ) . moxifloxacin and erythromycin - resistant c....
pentatomomorpha is a large group of many phytophagus as well as seed - eating insects , commonly called as plant bugs , with more than 10,000 species worldwide ( dolling , 1991 , schuh and slater , 1995 ) . morphology - based study of pentatomomorpha has a long history and several workers have recognized different su...	recent studies from east asia and canadian national collection of insects have established the utility of dna barcoding technique in identification of true bugs . the present study is an expansion of the database by adding mitochondrial cytochrome c oxidase i ( mtcoi ) sequences from forty three species of indigenous...
atrial myxomas are the most common primary heart tumors and predominantly considered to be benign lesions . case study : we report a case involving a 77-year - old woman who presented with a pelvic mass . she was found to have a primary endometrial cancer and primary lung cancer with concomitant metastatic adrenal ...	backgroundatrial myxomas are the most common primary heart tumors and predominantly considered to be benign lesions . case study : we report a case involving a 77-year - old woman who presented with a pelvic mass . she was found to have a primary endometrial cancer and primary lung cancer with concomitant metastati...
the first draft of the human genome sequence [ 1 , 2 ] was unveiled in february 2001 and surprisingly it was shown to contain ~23000 genes , only a fraction of the numbers of genes originally predicted . to put this into perspective the lack of an association between gene number and organismal complexity has resulted...	alternative splicing ( as ) is a common posttranscriptional process in eukaryotic organisms , by which multiple distinct functional transcripts are produced from a single gene . the release of the human genome draft revealed a much smaller number of genes than anticipated . because of its potential role in expanding ...
a median sternotomy that extends toward the epigastric area can weaken the upper abdominal wall and result in the development of subxiphoid incisional hernia ( fig . 1 ) . reported incidence of subxiphoid incisional hernia has ranged from 1% to 4.2% . the subxiphoid hernia is known for its repair complexities and h...	backgroundmedian sternotomy can weaken the upper abdominal wall and result in subxiphoid incisional hernia . we evaluated risk factors associated with the development of subxiphoid incisional hernias after coronary artery bypass grafting ( cabg).materials and methodsof 1,656 isolated cabgs performed between january 2...
besides lysine acetylation , we recently identified a variety of short - chain lysine acylations in core histones , including lysine propionylation , butyrylation , 2-hydroxyisobutyrylation , crotonylation , malonylation , succinylation , and glutarylation ( chen et al . , 2007 , dai et al . , 2014 , tan et al . ,...	summaryrecently discovered histone lysine acylation marks increase the functional diversity of nucleosomes well beyond acetylation . here , we focus on histone butyrylation in the context of sperm cell differentiation . specifically , we investigate the butyrylation of histone h4 lysine 5 and 8 at gene promoters wher...
robinia pseudoacacia ( black locust ) is the main honey - bearing tree that grows spontaneously in romania , especially in the plains and hills . only flowers are used for their alkalizing , antispasmodics , anti - tussives , sedatives effect , other parts of the plant especially bark and seeds are toxic [ 1 - 3 ] . ...	the purpose of this study was the qualitative and quantitative analysis of flavonoids from robinia pseudoacacia using two different techniques of analysis : thin layer chromatography ( tlc ) and tlc coupled with photo - densitometry . the results obtained by chromatographic analysis showed a higher concentration of f...
iterative methods are commonly used in single photon emission computed tomography ( spect ) reconstruction because of their ability to handle incomplete data and to incorporate a priori information in the process . because the sensitivity and resolution of spect are complex functions of many factors , such as s...	an spect image can be approximated as the convolution of the ground truth spatial radioactivity with the system point spread function ( psf ) . the psf of an spect system is determined by the combined effect of several factors , including the gamma camera psf , scattering , attenuation , and collimator response . i...
nasal swab specimens collected by using transwabs ( medical wire ltd , corsham , uk ) were collected from 100 pig carcasses at 2 wet markets in hong kong on 5 separate days over a 7-week period in 2008 . cross - contamination was minimized by selecting carcasses with intact nasopharyngeal tracts and by instructing th...	to determine whether spa type of methicillin - resistant staphylococcus aureus in pigs belonged to sequence type ( st ) 398 , we analyzed nasal swabs from pig carcasses at hong kong markets in 2008 . st9 belonging to spa type t899 was found for 16/100 samples , which indicates that a distinct lineage has emerged in p...
a nucleosome contains 146 bp of dna wrapped twice around an octamer composed of two copies of each histone protein : h2a , h2b , h3 , and h4 ( kornberg , 1974 ; kornberg and lorch , 1999 ) . nucleosomes are observed as a series of beads on a string via electron microscopy with the beads being the individual nucle...	histone h2b monoubiquitination by rad6/bre1 is required for the trimethylation of both histone h3k4 and h3k79 by compass and dot1 methyltransferases , respectively . the dependency of methylation at h3k4 and h3k79 on the monoubiquitination of h2bk123 was recently challenged , and extragenic mutations in the strain ba...
periprosthetic inflammatory masses or cysts are rare yet known complications of total hip arthroplasty ( tha ) . the inflammatory component is derived from histological findings , which include periarticular tissue necrosis and perivascular lymphocytic inflammation also known as aseptic lymphocyte - dominated vasculi...	a 71-year - old female with a history of right total hip arthroplasty presented with an enlarging pseudotumor . pseudotumor is a known complication following metal - on - metal and metal - on - conventional polyethylene and metal - on - highly cross - linked polyethylene implants . revision total hip arthroplasty f...
	we report asymmetric allylic alkylation of barium enolates of cyclic ketones catalyzed by a metallacyclic iridium complex containing a phosphoramidite ligand derived from ( r)-1-(2-naphthyl)ethylamine . the reaction products contain adjacent quaternary and tertiary stereocenters . this process demonstrates th...
the sine oculis homeobox 1 ( six1 ) gene , a homologue of the drosophila sine oculis ( so ) gene , belongs to the six gene family ; in vertebrates , in total of six members have been identified and which have been classified into three subgroups , six1/six2 , six3/six6 , and six4/six5 1 . to date , six family genes h...	the sine oculis homeobox 1 ( six1 ) gene encodes an evolutionarily conserved transcription factor . in the past two decades , much research has indicated that six1 is a powerful regulator participating in skeletal muscle development . in this review , we summarized the discovery and structural characteristics of six1...
	we report the development of a pd - catalyzed process for the stereospecific cross - coupling of unactivated secondary alkylboron nucleophiles and aryl chlorides . this process tolerates the use of secondary alkylboronic acids and secondary alkyltrifluoroborates and occurs without significant isomerization ...
myasthenia gravis ( mg ) is an autoimmune disease affecting approximately 100 patients per million populations . in mg , autoantibodies are developed against acetylcholine receptors at neuromuscular junctions , leading to fatigue and weakness after the repetitive use of voluntary muscles . mg occurs in a bimodal age ...	background : despite the widespread use of thymectomy in myasthenia gravis ( mg ) patients , it has remained controversial as to whether this procedure is of a similar efficacy and clinical outcome among mg patients with thymoma and thymic hyperplasia.aim:we sought to determine the long - term clinical outcomes of mg p...
the explosion of biological data brought about by the high - throughput technologies poses a great challenge to bioinformatics research . in order to learn the hidden structures of these high - dimensional data , nonnegative matrix factorization ( nmf ) nmf was quickly applied to various fields of biological data ana...	in the past decades , advances in high - throughput technologies have led to the generation of huge amounts of biological data that require analysis and interpretation . recently , nonnegative matrix factorization ( nmf ) has been introduced as an efficient way to reduce the complexity of data as well as to interpret...
in the previous issue of critical care , maggiore and colleagues contributed significantly to our understanding of the incidence and associated consequences of hypernatremia in neurocritical care . this retrospective cohort study was performed in 130 consecutive patients with severe traumatic brain injury admitted ...	there is mounting evidence , including the recent report by maggiore and colleagues , of an association between hypernatremia and mortality in patients with traumatic brain injury . this mandates a re - evaluation of routine administration of agents such as hypertonic saline for the management of intracranial hyperte...
non - hodgkin 's lymphoma ( nhl ) is the most common cancer of the lymphatic system and represents the fifth most frequent cancer in western countries . recent estimates of lymphoma incidence in italy predict that there will be nearly 15,000 new cases of nhl in 2011 . diffuse large b - cell lymphoma ( dlbcl ) is the ...	since anthracyclines were introduced in the treatment of non - hodgkin 's lymphoma in the late 1960s , they have been acknowledged as a cornerstone in the management of the disease and , in particular , of aggressive lymphomas . the high efficacy of anthracycline - containing regimens must , however , be balanced aga...
senior - friendly food products have gained widespread attention because the market of foods for elderly has grown rapidly with the growing elderly population ( kwak et al . , 2013 ) . considerable efforts have been put into the development of senior - friendly food products to improve nutrient utilization because el...	this study aimed to examine the nutrient utilization of rump round meat and lotus root using young ( 32 wk ) and aged hens ( 108 wk ) as an animal model . rump round meat and lotus root were prepared with or without enzymatic treatment . for each age group of laying hens , a total of 24 hy - line brown laying hens ...
balance control is a necessary component of stable walking . many adults change their walking pattern as they age , and this is expressed as decreases in walking velocity , step length , and adaptive responses that ensure safe gait1 . falls often lead to physical injury , such as fractures , and cause conside...	[ purpose ] this study investigated the effect of a motor dual - task balance program on balance and gait of elderly women to suggest a more effective balance exercise method . [ subjects ] twenty elderly korean women who could walk independently were recruited from the community dwelling . [ methods ] the moto...
despite breathtaking advances in science and technology , breast cancer still remains mankind 's one of the most dreaded maladies . timely diagnosis and well planned , and executed treatment strategy are the cornerstones of successful management of this entity . self - breast examination or a clinical breast examin...	introduction : fine - needle aspiration cytology ( fnac ) method is safe , reliable and time saving outdoor procedure with little discomfort to the patient for detecting carcinoma breast . the efficacy can further be enhanced when physical breast examination , mammography and fnac ( the triple test [ tt ] ) are joint...
the objective of which is to deliver integrated health services ( curative and preventive ) and to upgrade the health status of the community . the concept of phc was first formulated by lord dawson of england in 1920.1 a few years later it was propounded in new york and california . the concept attracted wide - sp...	primary health care ( phc ) is a new concept in the health field . its objective is to deliver integrated health service ( curative and preventive ) . the alama - ata conference in 1978 urged countries to adopt the phc approach to promote the health of all people . the expansion of phc created the need for variou...
leukemia occurs when the normal hematopoietic process fails , and the leukemic cells retain the proliferative capacity of progenitor cells and unable to spontaneously undergo terminal maturation . the cell line wehi-3b jcs is a d - subclone isolated from the wehi 3b myelomonocytic leukemia cell line . previous stud...	sj16 is an anti - inflammatory protein identified from schistosoma japonicum . our previous studies showed that recombinant sj16 ( rsj16 ) could suppress host 's inflammatory responses and inhibit macrophage maturation . in the present study , the effects of rsj16 on the differentiation of the murine myeloid leukem...
aging is a part of life occurring after middle age and is counted as a natural inevitable biological phenomenon . based on statistics reported by who , there will be 800 million elderly over 65 years of age all over the world by 2025 of whom 2/3 will be in developing countries . in iran , based on national census rec...	background : studies showed that poor quality of sleep is a common problem among the elderly . because of drug complications and side effects such as drug dependency and resistance and decrease of sleep depth in long - term intake of sleep medication , cognitive - behavior therapy including sleep restriction therapy wh...
	the heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline ( iq ) was evaluated for carcinogenic effects in macaques , primarily cynomolgus monkeys . iq was administered by gavage five times a week at doses of 10 or 20 mg / kg . iq induced hepatocellular carcinoma in 55% of the animals at the low dose ...
bioactive materials [ 1 , 2 ] are known to bond to living bone in the body through formation of an apatite layer on their surface . bioactive glasses and glass ceramics find a variety of biological applications such as in cell separation , drug delivery , and magnetic intracellular hyperthermia treatment of cancer [ ...	the present study aimed at studying the acceleration of the bioactive layer on the surface of ferrimagnetic glass ceramic with a basic composition 40fe2o315p2o520sio25tio2 through the addition of 20% of different types of metal oxides like mgo or cao or mno or cuo or zno or ceo2 . sem , edax , and icp were applied to...
diffuse optical tomography ( dot ) is a relatively new discipline and drew increasing interest in recent years [ 2 , 3 ] . if the target - specific fluorescent contrast agent is employed in dot , it can probe molecular event in vivo [ 46 ] , which is very useful to detect disease in its early stage , compre...	diffuse optical tomography ( dot ) is a rapidly growing discipline in recent years . it plays an important role in many fields , such as detecting breast cancer and monitoring the cerebra oxygenation . in this paper , a relatively simple , inexpensive , and conveniently used dot system is presented in detail , in w...
atherosclerotic disease is responsible for more than half of all mortality in developed countries ( 13 ) . neointima formation is an early step in the development of atherosclerotic plaques ( 2 , 3 ) . atherogenic lesions progress through a prolonged process of lipid accumulation , calcification , and inflammation ...	neointimal lesions are characterized by accumulation of cells within the arterial wall and are a prelude to atherosclerotic disease . here we report that a brief exposure to either alkyl ether analogs of the growth factor like phospholipid lysophosphatidic acid ( lpa ) , products generated during the oxidative modif...
methotrexate ( mtx ) is a folic acid antagonist and cell cycle - specific antimetabolite . while still an important component of hematological and solid tumor treatment regimens and ectopic pregnancies , low - dose mtx is now used to treat many autoimmune disorders , including crohn s disease , rheumatoid arthritis , a...	we describe a case of bilateral septic knee arthritis that followed the administration of methotrexate for nonsurgical termination of an ectopic pregnancy . we believe that methotrexate is a relatively effective alternative to surgery in patients with early unruptured tubal pregnancies , but suggest that it be used w...
eight percent of these individuals were thought to be in the low- and middle - income countries . india is home to the second largest number of people with diabetes . with rampant urbanization and a drastic change in lifestyle , the prevalence of type 2 diabetes ( the most common form of diabetes in india ) , this ...	background : india has the second largest population of persons with diabetes and a significant proportion has poor glycemic control and inadequate awareness of management of diabetes.objectives:determine the level of awareness regarding management of diabetes and its complications and diabetic care practices in india....
the annular pancreas is a rarely reported congenital anomaly that forms a ring of pancreatic tissue leading to partial or complete encirclement of the descending duodenum . 12 although it is usually found in neonates , the annular pancreas in an adult is reported infrequently.1 neonatal patients present with specific...	the annular pancreas in adults is a rare congenital anomaly that is detected after development of complications , such as gastric outlet obstruction , recurrent pancreatitis , and peptic ulcer . duodenal bypass is the procedure of choice for treating duodenal obstruction caused by the annular pancreas in both childre...
these structures are not only indispensable for atp production and participate in numerous intermediate metabolic reactions but also play a central role in calcium homeostasis , apoptosis , cell signaling , and differentiation . impairment of mitochondrial functions has been implicated in a wide variety of human path...	mitochondrial dna mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging . initial interest in mutations occurring in mitochondrial dna of cancer cells diminished when most were found...
retinal vein occlusion ( rvo ) is the second most frequent type of retinal vascular disorder after diabetic retinopathy and is reported to affect an estimated 16 million people in the world.13 rvo vision loss is a result of macular edema ( me ) , whose primary cause is vascular endothelial growth factor ( vegf).4 previ...	purposethe purpose of this study was to determine the clinical efficacy of low - frequency intravitreal ranibizumab to treat macular edema due to retinal vein occlusion ( rvo).patients and methodsthis was a retrospective examination of cases that received intravitreal ranibizumab for untreated rvo over a period of 12 m...
bite marks may be found at the scene of a crime and their analysis has been used for many years as an aid in forensic investigation . bite marks can occur on the skin of a victim or on other objects , including foods such as cheese , chocolate , apples , or chewing gums . bite marks tend to have a double horseshoe ...	aim : to evaluate the best method of overlay generation out of the three methods , i.e. , manual , photocopying , and computer assisted method.materials and methods : impressions of maxillary and mandibular arches of 25 individuals participating in the study were made and dental study models were prepared . overlay p...
inflammatory bowel disease ( ibd ) is a chronic immune - mediated disease of the gastrointestinal tract that affects more that 1.6 million americans.1,2 ulcerative colitis ( uc ) is characterized by diffuse , continuous , superficial , and ulcerating inflammation confined to the colon that causes rectal bleeding , diar...	ulcerative colitis ( uc ) is an immune - mediated disease of the colon that is characterized by diffuse and continuous inflammation contiguous from the rectum . half of uc patients have inflammation limited to the distal colon ( proctitis or proctosigmoiditis ) that primarily causes symptoms of bloody diarrhea and ur...
while cardiac magnetic resonance imaging ( mri ) has been used to evaluate the myocardium in terms of the myocardial function , perfusion , and viability , rather than coronary stenosis ; coronary magnetic resonance angiography ( cmra ) is currently considered a reliable imaging test for the evaluation of coronary anat...	coronary magnetic resonance angiography ( cmra ) allows a noninvasive assessment of the coronary anatomy without exposing the patients to radiation . it is also superior to coronary computed tomography angiography ( ccta ) for the evaluation of luminal narrowing in heavily calcified coronary segments . we report a ...
amyloidosis is a proteinmisfolding disorder characterized by the deposition of insoluble abnormal amyloid fibrils into tissues , leading to organ dysfunction . cardiac amyloid infiltration is most commonly due to immunoglobulin light chains ( al ) secreted by clonal plasma cells or by transthyretin ( attr ) , a prote...	backgroundlight chain ( al ) and transthyretin ( attr ) amyloidosis have a similar effect on myocardial function but very different disease trajectories and survival . however , limited data are available evaluating subtypespecific predictors of outcomes in a large contemporary cohort.methods and resultswe retrospectiv...
there is little disagreement in the medical community regarding the importance of providing preventive health care to children . although there is some controversy concerning the relative effectiveness of certain services , there is general consensus that some schedule of medical visits for children is needed . beyon...	in this article , we measure the extent to which california medicaid children in 1981 received preventive care services through either the regular or the early and periodic screening , diagnosis , and treatment component of medicaid . on average , 62 percent of children up to 15 years of age who were continuously enrol...
spitzoid neoplasms may pose significant diagnostic problems , because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions . an extraordinarily large number of studies have been made in attempts to solve the problem of the differential diagnosis of spitzoid ne...	summarybackground : spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions . an extraordinarily large number of studies have been made in attempts to solve this problem ; regrettably , the histolo...
oral diseases are major health problems with dental caries and periodontal diseases among the most important preventable global infectious diseases . oral health influences the general quality of life , and poor oral health is linked to chronic conditions and systemic diseases . the development of dental caries inv...	background : the tobacco plant , nicotiana tabacum , has been responsible for more deaths than any other herb . however , the literature has also been endowed with its use as holy herb since the pre - columbian era . used for treating pain , poisonous bites , ulcers , nasal polyps , and basal cell carcinoma ; it al...
gastrointestinal symptoms such as abdominal pain , vomiting , retching , diarrhea , and spitting are known to occur as ictal phenomena during partial seizures , mostly of temporal or insular origin . recognizing such autonomic signs is crucial to identifying partial seizures and can help in localizing the epileptogen...	the prevalence and localizing value of ictal belching are yet unknown . we present the case of a patient with medically refractory focal epilepsy with simple and complex partial seizures , as well as generalized seizures . one presumed seizure type comprised frequent episodes of repetitive belching . video - eeg ...
data from the baseline survey ( 20092011 ) of the nationwide , population - based cohort study , clinical course of type 1 diabetes in children , adolescents and young adults with disease onset in preschool age ( diabetes study ) , were used . the study was approved by the responsible commissioner for data protecti...	objectiveto evaluate self- and parent reports of general health status and health - related quality of life ( qol ) in children and adolescents with early - onset and long - lasting type 1 diabetes compared with the general population in germany.research design and methodsa total of 629 subjects aged 11 to 17 years , w...
the incidence of glioblastoma multiforme ( gbm ) is less common in children than in adults . the prognosis in children appears to be better than the adult counterpart as seen in various studies.[13 ] multiple lesions in gbm are found in 2 instances : multifocal and multicentric . a gbm is said to be multifocal when...	glioblastoma multiforme ( gbm ) is the most common primary malignant brain tumor . gbm in children is less common than in adults and has a better prognosis . pediatric gbm is a rare entity , and a multifocal development in a pediatric gbm is much rarer . we report to you one such rare case of pediatric multifocal...
the program was funded by the australian government department of health and aging , and developed and implemented by trauma , disaster and health promotion experts from the australian centre for posttraumatic mental health ( acpmh ) , the mater hospital brisbane and beyondblue as part of the victorian government s bus...	this study reports data on a disaster mental health training program to enhance the capacity of lay people from disaster - affected communities , to provide assistance to others following a bushfire disaster . local facilitators conducted training sessions which were actively promoted within communities . participa...
nitrofurantoin is an effective agent for the treatment and an appropriate prophylactic antibiotic choice for recurrent urinary tract infections . adverse reactions to nitrofurantoin after short term and long term use are well documented which include : lupus like syndrome , arthralgias , leucopenia , hemolysis , pneu...	nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection . it is associated with a wide range of adverse drug reactions . chronic active hepatitis has increasingly been observed and many cases have been reported with case fatalities . we present a case ...
postnatally , it consists of an ectodermally derived hair shaft surrounded in its sub - epidermal portion by an inner root sheath ( irs ) . the shaft and irs are formed through terminal differentiation of transiently proliferating cells of the hair matrix . the outer root sheath ( ors ) encases the entire hf and is...	summarywe show that removing the shh signal tranducer smoothened from skin epithelium secondarily results in excess shh levels in the mesenchyme . moreover , the phenotypes we observe reflect decreased epithelial shh signaling , yet increased mesenchymal shh signaling . for example , the latter contributes to exube...
fascioliasis is a zoonotic disease caused by liver parasites , fasciola hepatica and f. gigantica(1 ) . it is one of the important neglected tropical diseases disseminated in most parts of the world and especially in the middle east and parts of the africa ( 2 ) . about 56.2 million people were infected with food -...	backgroundthe aim of this study was to detect the seroprevalence of human fascioliasis in isfahan county , central iran in 2013.methodsoverall , 471 sera samples were collected from people recalled randomly to 20 health centers in the city of isfahan and 10 related villages in 2014 . sera were examined using elisa te...
central venous catheters ( cvcs ) are frequently used for purposes such as accurate hemodynamic monitoring , efficient administration of medication and nutritional support , and renal replacement therapies . despite its usefulness , the insertion , maintenance , and removal of a cvc bear the possibilities of various ...	abstractair embolism following central venous catheter ( cvc ) removal is a relatively uncommon complication . despite its rare occurrence , an air embolism can lead to serious outcomes . one of the most fatal complications is cerebral air embolism.we report a case of cerebral air embolism that occurred after the r...
toxoplasma gondii is a protozoan parasite , which is known to cause opportunistic infections in the immunocompromised , as in solid - organ transplant [ 1 , 2 ] . toxoplasmosis in transplant recipients may result either from transmission with the transplanted organ from a toxoplasma - seropositive donor to a seronega...	primary toxoplasmosis and reactivation of latent infections occur in solid organ transplant recipients . however , solitary cerebral lesions due to toxoplasmosis are rare . in this case , a patient presented with a haemiparesis and a cerebral lesion . we expected to find cerebral post - transplant lymfoproliferative ...
dry eye disease is a common condition , particularly affecting women and the elderly.1 a wide variation in the prevalence of dry eye disease , ranging from < 0.1% to as high as 33% , has been reported.2 this wide variation is related to differences in definitions , diagnostic criteria , and study populations ( eg , pop...	purposeto assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms.methodsa total of 1,419 patients ( 74.3% women , mean age 58.9 years ) with dry eye syndrome using artificial tears participated in a 12-week prospective study . patients were instructed to ...
infection of the prosthetic joint after total knee arthroplasty ( tka ) occurs in up to 2% of patients . various treatment options exist : dbridement with retention of the prosthesis , reimplantation arthroplasty ( one- and two - stage procedures ) , permanent prosthesis removal ( resection arthroplasty , arthrodesis...	our objective was to evaluate different treatment alternatives for total knee arthroplasty ( tka ) infection and to compare outcomes depending on adherence to a current treatment algorithm . all patients treated for a first episode of tka infection between january 2000 and july 2005 were included . patient records ...
in europe , the neolithic transition marked the beginning of a period of innovations that saw communities shift from a mobile lifestyle , dependent on hunting and gathering for survival , to a more sedentary way of life based on food production . this new lifeway , which originated in the near east 11,500 calibrated ...	summarythe neolithic transition was a dynamic time in european prehistory of cultural , social , and technological change . although this period has been well explored in central europe using ancient nuclear dna [ 1 , 2 ] , its genetic impact on northern and eastern parts of this continent has not been as extensively...
percutaneous nephrolithotomy ( pcnl ) is a well - established , minimally invasive treatment modality for the management of renal calculi . it is the first - line treatment option for large or multiple kidney stones and stones in the inferior calyx . greater surgeon experience and improvements in instruments ( i.e. ,...	introduction and objectives : to prospectively document the perioperative complications of percutaneous nephrolithotomy ( pcnl ) using the modified clavien grading system . evaluation of complications and clearance rates according to stone complexity using the validated guy 's stone score ( gss ) was also done.materi...
carnitine is a natural substance , which is not only supplied through the intake of protein - rich foods , but also synthesized by the liver , kidney and brain , and excreted from the kidney in humans . because about 80% of serum carnitine is eliminated from the blood via hemodialysis ( hd ) [ 1 , 2 ] , carnitine defic...	backgroundcarnitine deficiency may contribute to cardiovascular disease ( cvd ) in patients with hemodialysis ( hd ) . dyslipidemia plays a role in cvd and its prevalence is also high in hd patients . we examined here the effects of switching from oral administration ( po ) to intravenous ( iv ) injection of l - ca...
infectious spondylodiscitis ( sd ) is an infection of intervertebral discs and adjacent vertebral bodies710 ) . various organisms including bacteria , tuberculosis , fungi , and parasites can cause sd7 ) . in the past , staphylococcus aureus , escherichia coli , proteus , klebsiella , pseudomonas aeruginosa , coagu...	objectivethe goal of this study is to evaluate the prevalence of spondylodiscitis ( sd ) caused by uncommon pathogens and review the efficacy of the treatment strategy including the coverage by usual empirical broad - spectrum antibiotic therapy.methodsninety-nine consecutive patients diagnosed and treated for infectio...
the giant cell tumor of the tendon sheath ( gctts ) is a benign lesion arising from the synovium of a joint , bursa or tendon sheath ( 13 ) . another name is the tenosynovial giant cell tumor , with gctts being the localized form of the diffuse type pvns ( 2 , 4 ) . the gctts most commonly seen in the fingers is ex...	the giant cell tumor of the tendon sheath ( gctts ) is a benign lesion which arises from the synovium of a joint , bursa or tendon sheath , with 85% of the tumors occurring in the fingers and 12% of the tumors located in large joints such as the knee and ankle . the gctts is usually monoarticular , slowly proliferati...
autophagy - related gene autophagy - related 16-like 1 endothelial pas domain - containing protein 1 gaba receptor - associated protein gaba receptor - associated protein - like 2 microtubule - associated protein 1 light chain 3 the cancer genome atlas unc-51 like autophagy activating kinase 2 uv radiation resistance a...	our recent study shows that autophagy collaborates with proteasomes to degrade endothelial pas domain - containing protein 1 ( epas1 , also known as hif2 ) in a manner dependent on von hippel - lindau ( vhl ) and sequestosome 1 ( sqstm1/p62 ) . the genetic dysregulation of autophagy is a common feature of different s...
	key clinical messageuterine inversion is rarely seen in adolescents in western countries . but it might be seen in teenagers and adolescents due to poor conditions and early pregnancies in africa . and early troubleshooting chronic uterine inversion represents an early resolution of the problem and allows planning ...

Subsets and Splits

No community queries yet

The top public SQL queries from the community will appear here once available.