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the primary amino acid sequence of a protein contains all the information necessary for protein folding and its biological activity .
however , in a normal cellular condition , a nascent polypeptide chain faces a crowded environment and there is a good possibility that protein will be misfolded and will form aggregat... | molecular chaperones are a class of proteins responsible for proper folding of a large number of polypeptides in both prokaryotic and eukaryotic cells .
newly synthesized polypeptides are prone to nonspecific interactions , and many of them make toxic aggregates in absence of chaperones . the eukaryotic chaperonin cc... |
febrile infection - related epilepsy syndrome ( fires ) , also known as devastating epileptic encephalopathy in school - aged children or acute encephalitis with refractory repetitive partial seizures , is an acute and explosive - onset epileptic encephalopathy with a fatal outcome , which occurs in previously healthy ... | purposethis report sheds light on a successful treatment in febrile infection - related epilepsy syndrome ( fires ) with the combined use of lidocaine and mgso4.methodswe report a 12-year - old previously healthy girl who experienced an upper respiratory infection with fever and headache for 2 days , then suddenly wen... |
in rodent brains images may become distorted due to instrument imperfections or , in the case of histology , tissue processing .
for example , magnetic field inhomogeneity causes geometric distortions in echo planar imaging ( epi ) mri ; mechanical forces acting on a harvested brain during slicing may cause tissue te... | purpose . to develop a technique to automate landmark selection for point - based interpolating transformations for nonlinear medical image registration .
materials and methods .
interpolating transformations were calculated from homologous point landmarks on the source ( image to be transformed ) and target ( refe... |
multiple primary malignancies ( mpms ) were initially described by billroth in 1889 and later defined by warren and gates as the presence of at least 2 unrelated primary malignancies in a single patient .
occurrences of mpms are rare and are described mostly as case reports , although there are reports from singl... | multiple primary malignancies ( mpms ) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others .
mpms are considered synchronous when they present within 6 months of one another . here ,
we report the case of a 57-year - old woman w... |
oxygen is vital for all aerobic biological processes . however , about 5% of it is converted into reactive oxygen species ( ros ) .
methionine residues in proteins are susceptible to oxidation by reactive oxygen and nitrogen species leading to formation of methionine sulfoxide ( metso ) .
organisms developed a comp... | maintenance of the cellular redox balance has vital importance for correcting organism functioning .
methionine sulfoxide reductases ( msrs ) are among the key members of the cellular antioxidant defence system . to work properly , methionine sulfoxide reductases need to be reduced by their biological partner , thior... |
left atrial myxoma is a benign primary cardiac tumor and a cause of embolic stroke .
nearly half of the benign heart tumors are myxomas , making it the most common heart tumor .
although classified as benign tumors , myxomas seem to grow and spread , but there is still debate as to whether they metastase or fragmen... | this is the first reported attempt to examine the emboliogenic potential of cardiac myxoma in patients with acute stroke through the monitoring of microembolic signals ( mes ) by transcranial doppler .
a 43-year old woman was brought to the emergency department because of acute onset of generalized tonic - clonic sei... |
in western countries , more than half of pregnant women take prescription medication , and nearly all pregnant women use over - the - counter medications , vitamins or other dietary supplements.14 drugs that are safe for adults may be teratogenic for the developing fetus .
the majority of drugs or their metabolites c... | more than half of all pregnant women take prescription medications , raising concerns about fetal safety .
medical databases routinely collecting data from large populations are potentially valuable resources for cohort studies addressing teratogenicity of drugs .
these include electronic medical records , administ... |
radiographs are an important method of diagnosing and monitoring oral diseases , dentofacial development , and the progress or prognosis of therapy.1 panoramic radiography is recommended for patients in several age ranges : children with transitional dentition ( after eruption of the first permanent tooth ) ; adolescen... | panoramic radiographs are a relatively simple technique that is commonly used in all dental specialties . in panoramic radiographs , in addition to the formation of real images of metal objects , ghost images may also form , and these ghost images can hinder an accurate diagnosis and interfere with the accuracy of radi... |
the bromeliaceae is one of the morphologically and ecologically most diverse flowering plant families native to the tropics and subtropics of the new world ( givnish et al . , 2011 ) .
its geographical distribution ranges from the states of virginia , texas , and california in the usa ( latitude 37 n ) to northern pa... | bromeliaceae is a morphologically distinctive and ecologically diverse family originating in the new world .
three centers of diversity , 58 genera , and about 3,140 bromeliad species are currently recognized .
we compiled all of the studies related to the reproductive biology , genetic diversity , and population s... |
management options for patients with low or intermediate risk prostate cancer and a life expectancy of less than 10 years include active surveillance ( 1 ) , radical prostatectomy ( 2 ) , external beam radiation therapy ( ebrt ) , low - dose rate ( ldr ) brachytherapy monotherapy ( 3 , 4 ) , or high - dose - rate ( hdr... | purpose there is little information in the literature on health - related quality of life ( hrqol ) changes due to high - dose - rate ( hdr ) brachytherapy monotherapy for prostate cancer.materials and methods we conducted a prospective study of hrqol changes due to hdr brachytherapy monotherapy for low risk or favorab... |
it is an irony of science that the discovery of fundamental principles is often delayed .
the nucleus is arguably the functionally most prominent cellular organelle as it houses the vast majority of the genetic information and is the exclusive site of essential processes including transcription , rna processing , rep... | trafficking of proteins and rnas is essential for cellular function and homeostasis .
while it has long been appreciated that proteins and rnas move within cells , only recently has it become possible to visualize trafficking events in vivo .
analysis of protein and rna motion within the cell nucleus have been part... |
primary therapy for locally invasive disease consists of external and intracavitary or interstitial irradiation , except in selected early cases that may be treated surgically with local excision or with brachytherapy alone .
radical surgery , which may involve partial or total pelvic exenteration , is generally rese... | advances in treatment have not recently been reported in rare primary vaginal adenocarcinomas . a 56-year - old woman with a chronic vaginal cyst and possible in utero diethylstilbestrol exposure presented with postmenopausal bleeding .
biopsy of the vagina revealed high - grade papillary serous adenocarcinoma .
mr... |
the annotations , sequences , and orthologous relationships of mouse and rat genes were retrieved from ensembl version 53 ( www.ensembl.org ) , whereas those of yeast genes were obtained from the saccharomyces genome database ( www.yeastgenome.org ) .
based on go , immune - related proteins have the annotation of go:... | it is of fundamental importance to understand the determinants of the rate of protein evolution .
eukaryotic extracellular proteins are known to evolve faster than intracellular proteins .
although this rate difference appears to be due to the lower essentiality of extracellular proteins than intracellular proteins... |
stroke is a leading cause of long - term disability , and the absolute number of patients with
stroke is increasing . of the neurological sequelae that cause functional disability ,
the incidence of gait disturbance due to hemiparesis is
reportedly relatively high among chronic stroke patients1 , 2 .
the occurr... | [ purpose ] to investigate the effects of a 30-day rehabilitation program using a slant
board on walking function in post - stroke hemiparetic patients . [ subjects and methods ] six
hemiparetic patients with gait disturbance were studied .
the patients were instructed to
perform a home - based rehabilitation p... |
the 14 human ascariasis cases were reported by human and animal health care providers to the maine department of health and human services ( dhhs ) or the maine department of agriculture , conservation and forestry .
patients with confirmed infection had excreted in stool 1 worm that was subsequently laboratory - ide... | ascaris is a genus of parasitic nematodes that can cause infections in humans and pigs . during 20102013
, we identified 14 cases of ascariasis in persons who had contact with pigs in maine , usa .
ascaris spp .
are important zoonotic pathogens , and prevention measures are needed , including health education , f... |
a 66-year - old woman presented to the emergency department with chest pain , dyspnea and sweating for the previous 4 hours after making a speech in front of a large group of people .
the initial electrocardiogram on admission showed t - wave inversion in leads v3 through v6 , and q - wave in leads v4 through v6 ( fi... | transient left ventricular apical ballooning is characterized by transient wall motion abnormalities involving the left ventricular apex and mid - ventricle in the absence of coronary arterial occlusion .
a 66-year - old woman presented to the emergency department with chest pain that mimicked acute myocardial infarc... |
chchd2 contains a chch domain , which is characterized by a twin cx9c motif ( 2 pairs of cysteines spaced by 9 residues ) .
similar to other chch domain - containing proteins , the cx9c motif is responsible for the import of chchd2 into the ims through the mia40-erv-1 system . as it contains an amino - terminal mitoc... | as the powerhouse of cells and gatekeeper for apoptosis , mitochondria control life and death .
chchd2 , a mitochondrial protein previously known to regulate metabolism , has recently been identified as an apoptosis inhibitor .
new data suggest a model in which chchd2 performs a prosurvival function by acting as bo... |
body balance is defined as the organism s ability to maintain the body s position without the aid of another person , excluding uncontrolled falls . in the evaluation of body
balance various methods and testing instruments are used , including the observation of oculovestibular reflexes , vestibulospinal reflexes , a... | backgroundthe aim of the research was an evaluation of 2 training programs covering the same standard physical activity in the initial stage ( warm - up ) and the main ( motor exercises ) as well as a separate end part in program a of stretching and in programme b of vibration training designed to improve the level of ... |
the term metabolic syndrome ( mets ) has been used to describe the combination and co - occurrence of abdominal obesity , insulin resistance , impaired glucose tolerance , hypertension , and dyslipidemia ( increased low - density lipoprotein / high - density lipoprotein [ ldl / hdl ] and triglycerides ) .
these cardi... | background : metabolic syndrome ( mets ) and type 2 diabetes mellitus in humans are associated with increased platelet activation and hyperreactivity of platelets to various agonists .
ossabaw swine develop all the hallmarks of mets including obesity , insulin resistance , hypertension , dyslipidemia , endothelial dy... |
percutaneous nephrolithotomy ( pcnl ) is the favored endourologic procedure for large ( > 20 mm ) renal calculi , offering patients a low - morbidity procedure with high efficacy in terms of stone clearance .
pcnl has proved its efficacy and has stood the test of time compared with open surgical techniques and extrac... | introduction : percutaneous nephrolithotomy is the most complicated stone surgery technique to learn . the steep learning curve is related mainly to obtaining precise renal access by puncturing the targeted calyx .
a minimally misaligned puncture may lead to torrential bleeding , failure of the surgery , and complica... |
vaginal hysterectomy with repair ( vhr ) of the anterior and posterior vaginal wall is often required to provide functional and lasting relief to women who present with prolapse of the vagina , cervix , and uterus out of introitus , especially near or after menopause . according to studies by wu et al1 and luber et al,... | the present study was conducted to investigate the trends of vaginal hysterectomy for genital prolapse in last 20 years by analyzing case records of affected women.during the analysis period , 4831 women underwent hysterectomy ; records of 4223 ( 87.5% ) were available . of these , 911 ( 21.6% ) ,
2.7% of 34,080 gyne... |
antimalarial compounds
consisting of two 4-amino-7-chloroquinoline
( 4,7-acq ) components linked by flexible tethers were identified as
some of the first small molecule botulinum neurotoxin serotype a light
chain ( bont / a lc ) inhibitors . shortly
thereafter , we discovered that antimalarial agents compose... | significantly
more potent second generation 4-amino-7-chloroquinoline
( 4,7-acq ) based inhibitors of the botulinum neurotoxin serotype a
( bont / a ) light chain were synthesized . introducing an amino group
at the c(3 ) position of the cholate component markedly increased potency
( ic50 values for such deri... |
spine disorders affect various sections of the spine and have a variety of causes1 , 2 .
most back pain occurs in the lumbo - sacral and cervical regions of the spine .
low back pain
is defined as pain localized between the ribs and the gluteal folds , with or without
symptoms in a lower limb .
pain in the up... | [ purpose ] spine disorders affect various sections of the spine and have a variety of
causes .
most pain occurs in the lumbo - sacral and cervical regions .
dance is associated
with exercise .
high levels of physical activity predispose to back pain occurrence .
[ subjects and methods ] the subjects were 2... |
hepatitis c virus ( hcv ) is a small , hepatotropic , positive - strand rna virus with a genome of approximately 9.6 kb in length.1,2 the hcv genome consists of a single open reading frame that encodes viral proteins and a 5 and 3 noncoding region ( ncr ) .
the 5 ncr contains the internal ribosome entry site that ini... | hepatitis c virus ( hcv ) infection is a major global health problem .
there is no effective vaccine and the current treatment regimen with pegylated interferon and ribavirin is associated with significant adverse events .
therefore , there is an urgent need to identify new antiviral targets for hcv therapy . in r... |
any pink color within a melanocytic lesion can be regarded as a marker for inflammation and has long been recognized as a clinical clue to melanoma [ 1 , 2 ] . in melanomas without significant pigmentation , either amelanotic or hypomelanotic , a subset of these dermoscopically visible areas has been called milky - re... | background . in dermoscopic images ,
multiple shades of pink have been described in melanoma without specifying location of these areas within the lesion . objective .
the purpose of this study was to determine the statistics for the presence of centrally and peripherally located pink melanoma and benign melanocyti... |
alveolar bone defects are created by different factors such as accidental trauma , surgical trauma from tooth extraction , infections , developmental anomalies and periodontal disease [ 1 , 2 ] .
this can cause alveolar ridges with a reduced width and height leading to a great challenge in prosthetic reconstruction a... | objectives : considering the importance of bone augmentation prior to implant placement in order to obtain adequate bone quality and quantity , many studies have been conducted to evaluate different techniques and materials regarding new bone formation . in this study , we investigated the bone healing capacity of two ... |
otogenic infections rarely cause pneumocephalus . in 1884 , chiari reported the first case of pneumocephalus on an autopsy done in patient of ethmoiditis . in 1926
review of literature by andrew and canalis . revealed head trauma as the leading cause of otogenic pneumocephalus ( 36% ) .
other causes were otogenic i... | pneumocephalus is a rare complication of chronic otitis media . despite its rarity
intra - cranial air carries a potential risk of increased intra - cranial pressure or meningitis , which requires immediate therapy .
a 10-year - old child presented to us with complaints of fever , headache , vomiting , and decrease... |
after independence days , health care coverage has evolved a great deal in african countries . in the 1970s in senegal country located in west africa ,
however , the state s disengagement from social sectors , in particular , healthcare , due to the economic downturn has dealt a blow to the free health care coverage ... | nowadays in senegal , located in west africa , social protection institutions are confronted with a substantially increased healthcare expenditure in general , and oral care in particular . the ability of the leadership to use techniques to contain the impact of risks they are facing determine their viability .
the a... |
a central but as yet unanswered question in cell biology concerns the amount of phospholipids or tag that is required in a living cell : how is lipid homeostasis regulated in coordination with nutritional and environmental conditions ?
the cellular tag content in yeast varies dramatically between different stages of ... | the endemic increase in lipid - associated disorders such as obesity and type 2 diabetes mellitus has placed triacylglycerol metabolism and its associated organelle , lipid droplets , in the spotlight of biomedical research .
key enzymes of triacylglycerol metabolism are structurally and functionally conserved betwee... |
a retrospective cohort study was conducted on 31 type 1 diabetic recipients of itx ( itx alone , n = 25 ; islet after kidney , n = 6 ) between 2001 and 2007 .
procedures were performed as described ( 1 ) under protocols approved by the university of miami health research ethics board , and informed consent was obtain... | objective to determine the impact of islet transplantation ( itx ) on hypoglycemia awareness in patients with unstable type 1 diabetes and its relation to islet function.research design and methods a total of 31 itx recipients were studied .
hypoglycemia unawareness was assessed using the clarke hypoglycemic score ... |
patients were recruited between february 2005 and june 2007 from the university hospitals of st .
olav , akershus , stavanger , haukeland , and north norway as well as levanger hospital .
inclusion criteria were age 1840 years , insulin - dependent diabetes with positive test for gada and/or ia-2a ( antibodies agai... | objectivecontinuous -cell rest with diazoxide preserves residual endogenous insulin production in type 1 diabetes .
however , side effects have hampered therapeutic usefulness . in a double - blind study
, we tested whether lower , intermittent dosing of diazoxide had beneficial effects on insulin production , meta... |
asthma ( mim 600807 ) is a common chronic respiratory disease resulting from the complex interaction of genetics and environmental factors .
short - acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics . activated b2-adrenergic receptor ( adrb2 ) stimulates adenyly... | short - acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics .
the aim of this study was to test whether genetic variants in pde4d gene , a key regulator of b2-adrenoceptor - induced camp turnover in airway smooth muscle cells , affect the response to short - actin... |
an estimated 157,500 surgical site infections ( ssis ) associated with inpatient surgeries occurred in the united states in 2011 according to a prevalence survey by the u.s .
centers for disease control and prevention ( cdc ) 1 . in spite of improvements in operating room practices , sterilization methods , physical ... | background : infection remains among the main reasons for joint prosthesis failure .
preclinical reports have suggested that antibacterial coatings of implants may prevent bacterial adhesion and biofilm formation .
this study presents the results of the first clinical trial on an antibiotic - loaded fast - resorbab... |
this is based on visual recognition of particular patterns of distinct cells indicative of specific or general cellular processes .
however , it can be difficult or impossible to disambiguate cells in fixed sections using standard illumination methods . in the context of solid tumors , multiple molecular markers par... | background : multispectral microscopy and multiple staining can be used to identify cells with distinct immunohistochemical ( ihc ) characteristics .
we present here a method called hypothesized interaction distribution ( hid ) analysis for characterizing the statistical distribution of pair - wise spatial relationsh... |
chronic mitral regurgitation ( mr ) results in a state of chronic volume overload for the left ventricle ( lv ) , resulting in compensatory dilatation .
this process , known as remodeling , is similar to changes occurring after myocardial infarction or with dilated cardiomyopathy , ultimately resulting in lv failure ... | summarybackgroundchronic mitral regurgitation ( mr ) results in a state of chronic left ventricular ( lv ) volume overload , resulting in compensatory dilatation .
mitral valve ( mv ) surgery for regurgitation reduces lv preload but increases lv afterload .
few data are available documenting subsequent changes in l... |
traumatic spinal cord injury ( sci ) affects over 200,000 people in the usa , with nearly 10,000 new injuries reported annually [ 13 ] .
people affected by sci are usually young ( average age 32 years ) and life expectancy is marginally lower when compared with a non - sci population . hence , the ramifications of th... | traumatic spinal cord injury ( sci ) affects over 200,000 people in the usa and is a major source of morbidity , mortality , and societal cost .
management of sci includes several components .
acute management includes medical agents and surgical treatment that usually includes either all or a combination of reduct... |
the carotid body ( cb ) , a neural - crest - derived paired organ located in the carotid bifurcation , is the main arterial chemoreceptor in mammals and facilitates reflex hyperventilation during hypoxia ( lpez - barneo et al . , 2001 ) .
in addition , the cb is able to undergo neurogenesis to contribute to acclimat... | summaryadult stem cell plasticity , or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types , has been a matter of debate in the last decade .
neural - crest - derived stem cells ( ncscs ) display a remarkable plasticity during development .
whether adult populations of ... |
educator highlights for cbe lse show how professors at different kinds of institutions educate students in life sciences with inspiration and panache . if you have a particularly creative teaching portfolio yourself , or if you wish to nominate an inspiring colleague to be profiled , please e - mail laura hoopes at lh... | note from the editoreducator highlights for cbe lse show how professors at different kinds of institutions educate students in life sciences with inspiration and panache . if you have a particularly creative teaching portfolio yourself , or if you wish to nominate an inspiring colleague to be profiled , please e - mai... |
3d printing, has been used in the clinical sciences for planning complex surgeries and designing custom implants .
the introduction of low - cost consumer - grade 3d printers enables this technology to be used for more routine procedures , although its application in rt has not been widely published .
these 3d prin... | technological advances have influenced practice patterns and innovation in many health disciplines , including respiratory therapy .
collaborative approaches and knowledge - sharing environments are vital in addressing problems and adopting emerging technology .
this article illustrates how the emergence of low - c... |
the mammalian cns is inferior to that of invertebrates in the sense that regeneration is extremely limited ( tanaka and ferretti , 2009 ) . in that sense
the optic nerve has the same organization and three types of glial cells as the cns white matter .
breakthrough in the field of optic nerve regeneration not only ... | optic nerve regeneration is an important area of research .
it can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases .
there are many hurdles impeding optic regeneration in mammals .
the mammalian central nervous system is non... |
the annual incidence of aneurysmal subarachnoid hemorrhage ( asah ) is about nine people per 100,000 population.2 ) the population - based mortality of subarachnoid hemorrhage ( sah ) is 38%,8 ) 1015% of patients with asah die before they arrive at the hospital , and a further 5% of patients die within the first 24 hou... | objectiveto report the procedure related complication rate of endovascular treatments ( evts ) performed on patients with aneurysmal subarachnoid hemorrhage ( asah ) under local anesthesia ( la).materials and methodsthis study enrolled 186 patients who underwent evt for ruptured aneurysm under la from january 2009 to d... |
increasing awareness of the important role of vitamin d for bone and other diseases has led to increased 25-hydroxyvitamin d [ 25(oh)d ] testing ( d represents d3 and d2 forms ) . however , variability within and between methods and laboratories has often compromised correct diagnosis and the ability to compare results... | vitamin d status in different populations relies on accurate measurement of total serum 25-hydroxyvitamin d [ 25(oh)d ] concentrations [ i.e. , 25(oh)d3 and 25(oh)d2 ] .
this study evaluated agreement between the advia centaur vitamin d total assay for 25(oh)d testing ( traceable to the nist - ghent reference method ... |
particle - stabilized
emulsions , otherwise known as pickering emulsions ,
have been recognized for more than a century .
many classes of particles including silica , polymer latexes , and clays can be used to stabilize such emulsions , with surface wettability
usually dictating the emulsion type .
thus relat... | polymerization - induced
self - assembly ( pisa ) is used to prepare
linear poly(glycerol monomethacrylate)poly(2-hydroxypropyl
methacrylate)poly(benzyl methacrylate ) [ pgma phpma pbzma ]
triblock copolymer nano - objects in the form of a concentrated aqueous
dispersion via a three - step synthesis based o... |
it has long been established that t cells are mediators of the pathology of multiple sclerosis ( ms ) in both murine models and patient studies [ 16 ] .
although , the impact of b cells and their antibody products in mediating the pathology of ms has long been considered [ 710 ] , their contributions have been more r... | multiple sclerosis is a chronic debilitating autoimmune disease of the central nervous system .
the contribution of b cells in the pathoetiology of ms has recently been highlighted by the emergence of rituximab , an anti - cd20 monoclonal antibody that specifically depletes b cells , as a potent immunomodulatory ther... |
pain is a significant problem in cancer patients and is often the most feared aspect of the disease ; thus , effective analgesia is an essential component of pain management .
cancer patients require a comprehensive pain treatment plan that not only addresses the moderate to severe background cancer pain ( bcp ) but ... | purposewe evaluated the prevalence and characteristics of breakthrough cancer pain ( btcp ) in korean patients admitted with cancer pain.materials and methodsin - hospital patients with cancer pain completed a questionnaire concerning severity of background cancer pain ( bcp ) , prevalence and treatment for btcp , slee... |
a rpbphp2 gene was kindly provided by eric giraud ( institute for research and development , france ) .
ifp1.4 gene was de novo synthesized by genscript company , based on the available protein sequence .
the dna sequence was optimized with proprietary optimumgene algorithm ( gensript ) , taking into account the... | the ability of non - invasive monitoring of deep - tissue developmental , metabolic , and pathogenic processes will advance modern biotechnology .
imaging of live mammals using fluorescent probes is more feasible within a near - infrared optical window
( nirw)1 .
here we report a phytochrome - based near infra -... |
every year thousands of infants , children , adolescents and young adults die suddenly and unexpectedly.1 of these a significant proportion are autopsy negative and are classified as autopsy negative sudden , unexplained death.1 sudden unexpected death in infancy ( sudi ) is defined as clinically unexpected death in in... | sudden and unexpected death in the young is a common and worldwide problem .
sudden , unexpected death in infancy ( sudi ) , clinically unexpected death in an infant between one week and one year of age , affects around 1 in 1000 infants .
autopsy will reveal a specific cause of death in only one third of cases .
... |
many lifestyle interventions use calorie restriction ( cr ) , defined as a reduction in caloric intake without malnutrition , as a key tool to improve health .
indeed , cr appears to beneficially affect physiology and biomarkers related to cardiometabolic health , even in non - obese populations .
a prime example o... | background : delayed immunologic aging is purported to be a major mechanism through which calorie restriction ( cr ) exerts its anti - aging effects in non - human species .
however , in non - obese humans , the effect of cr on the immune system has been understudied relative to its effects on the cardiometabolic sys... |
ninety six well plates ( flat bottom with lid ) ( corning inc . , one riverfront plaza , ny , usa ) , muller hinton broth ( mhb ) and muller hinton agar ( mha ) ( becton dickinson , franklin lakes , nj , usa ) and chloramphenicol ( sigma - aldrich , buchs sg , switzerland ) were used .
sodium chloride and dimethysulp... | the crabapple mangrove tree , sonneratia caseolaris linn .
( family : sonneratiaceae ) , is one of the foreshore plants found in estuarine and tidal creek areas and mangrove forests .
bark and fruit extracts from this plant have previously been shown to have an anti - oxidative or cytotoxic effect , whereas flower ... |
endothelial polarity is assumed to be mechanistically similar to that of epithelial cells , where it is well studied .
undoubtedly , the morphological and molecular organization of the vascular endothelial cells ( ecs ) at any of the diverse blood - tissue interphases must reflect the highly polarized environment in ... | summarythe vascular endothelium operates in a highly polarized environment , but to date there has been little exploration of apicobasal polarization of its signaling .
we show that vegf - a , histamine , igfbp3 , and lpa trigger unequal endothelial responses when acting from the circulation or the parenchymal side ... |
ochronosis ( alkaptonuria ) is a rare inborn error of metabolism with an incidence of < 1 per 250,000 live births.1 the cause of alkaptonuria is the lack of an enzyme homogentisate 1,2-dioxygenase , which results in an accumulation of homogentisic acid .
some of the homogentisic acid is secreted in urine , while the ... | alkaptonuria is a rare inborn error of metabolism , which is classified as an orphan disease .
it is due to the lack of an enzyme homogentisate 1,2-dioxygenase , which results in an accumulation of homogentisic acid in different areas of the body , including sclera , skin , cardiac valves , articular cartilage of the... |
key language abilities , such as perception and production , are governed by multiple regions in the brain .
these abilities can quickly become jeopardized in people with brain tumors , epilepsy , or other structural abnormalities .
many of these patients require resection of pathological tissue near eloquent langu... | objectivepatients requiring resective brain surgery often undergo functional brain mapping during perioperative planning to localize expressive language areas . currently , all established protocols to perform such mapping require substantial time and patient participation during verb generation or similar tasks
. th... |
chronic granulomatous disease is a hereditarily determined illness , characterized by inability of the body 's phagocytic cells to destroy certain microorganisms . as a consequence ,
patients with cgd have an increased susceptibility to infections caused by certain bacteria and fungi ( frequently staphylococcus aureu... | chronic granulomatous disease ( cgd ) is a primary immune deficiency disorder of the phagocytes . in this disorder , phagocytic cells ( polymorphonuclear leukocytes and monocytes )
can not produce active oxygen metabolites and , therefore , can not destroy the ingested intracellular bacteria .
clinically , patients... |
dietary berries , a rich source of bioactive compounds , especially the polyphenols , have been associated with protective effects against chronic diseases , especially lowering risk factors of cardiovascular disease ( cvd ) [ 13 ] .
oxidative stress is one of the major contributors to the pathophysiology of cvd and ... | berries have shown several cardiovascular health benefits and have been associated with antioxidant functions in experimental models .
clinical studies are limited .
we examined the antioxidant effects of freeze - dried strawberries ( fds ) in adults [ n = 60 ; age : 49 10 years ; bmi : 36 5 kg / m2 ( mean sd )... |
fungal endocarditis is an uncommon occurrence ; its incidence was reported as 1.3 to 6% of infective endocarditis cases ( 1 ) .
aspergillus species contributes to approximately 25% of all cases of fungal endocarditis , second to the candida species in frequency .
several conditions predispose patients to aspergillu... | systemic infection with aspergillus is an opportunistic disease that affects mainly immunocompromised hosts , and is associated with a high mortality rate .
it typically occurs in patients with several predisposing factors , but aspergillus endocarditis of native valves is rare and experience in diagnosis and treatme... |
to report a case of a cyclodialysis cleft that was successfully managed with gas endotamponade and cyclocryotherapy .
a 37-year - old male victim of a severe blunt ocular trauma was referred to our service for evaluation and treatment of a left eye hypotony .
clinical examination revealed an intraocular pressure of... | purposeto report a case of a cyclodialysis cleft that was successfully managed with gas endotamponade and cyclocryotherapy.methodsa 37-year - old male victim of a severe blunt ocular trauma was referred to our service for evaluation and treatment of a left eye hypotony .
clinical examination revealed an intraocular p... |
across the developed world , the provision and financing of long - term care is increasingly becoming a central policy issue , challenging policymakers and governments alike.1 changing dynamics in both the demographic composition of the population and the policy context in the area of long - term care , underpin the ac... | backgroundpopulation ageing is a global challenge and understanding the dynamics of living arrangements in later life and their implications for the design of appropriate housing and long - term care is a critical policy issue .
existing research has focused on the study of transitions into residential care in the uk... |
patients undergoing induction chemotherapy for acute leukemias are at a particularly high risk of developing neutropenic fever ( nf ) due to the prolonged duration of severe neutropenia . in the majority of these cases ,
the rapid administration of broad spectrum antimicrobials decreases the risk of progression to se... | neutropenic fever ( nf ) is a life - threatening complication of myelosuppressive chemotherapy in patients with hematologic malignancies and triggers the administration of broad - spectrum antimicrobials .
the ability to accurately predict nf would permit initiation of antimicrobials earlier in the course of infectio... |
radiotherapy plays an important role in the management of head and neck cancer , especially oropharyngeal and nasopharyngeal cancer .
radiotherapy is usually recommended as the primary treatment , as an adjunct to surgery , in combination with the chemotherapy , or as a palliative measure .
the radiation dose neede... | oral changes following radiotherapy are not uncommon .
oral mucositis , alteration in salivary gland function , radiation caries , and gingival changes have all been reported following radiotherapy and chemotherapy .
the gingival changes seen after radiotherapy may be unusual and often cause diagnostic dilemma .
... |
microspordia are emerging pathogens in recalcitrant stromal keratitis.1 the disease is difficult to diagnose both clinically and by laboratory diagnosis .
existing reports have shown clinical and histological evidence that the disease is restricted to the stroma , with no recurrence after penetrating keratoplasty.12 ... | we report a rare case of a deep stromal keratitis with a chronic indolent course , diagnosed as microsporidial keratitis from corneal scrapings .
the patient s condition worsened despite medical therapy and penetrating keratoplasty was performed .
the histopathology of the corneal tissue revealed multiple microspor... |
diabetic neuropathy is the most common microvascular complication of diabetes , and it is a major cause of morbidity and mortality .
neuropathy is estimated to be present in 10%90% of the patients with diabetes although it changes according to diagnostic criteria and patient population .
diabetic peripheral neuropa... | aim .
this study compares the effectiveness of michigan neuropathy screening instrument ( mnsi ) , neurothesiometer , and electromyography ( emg ) in detecting diabetic peripheral neuropathy in patients with diabetes type 2 .
materials and methods .
106 patients with diabetes type 2 treated at the outpatient clin... |
epilepsy , which is characterized by recurrent seizures , is one of the most common neurological disorders in the world .
abnormal synchronization of neuronal discharges plays critical role in seizures ( carlen et al . , 2000 ) . besides chemical synapses , direct coupling via gap junction ( gj ) channels provides a ... | there are abundant studies indicating that blocking gap junctions ( gjs ) containing connexin 36 ( cx36 ) inhibit seizures .
however , recent evidences demonstrate proconvulsant effect of such intervention . electrical coupling between gabaergic interneurons in ca1 region of hippocampus is mediated through cx36 gjs .... |
two molecules of each of the core histone proteins - h2a , h2b , h3 and h4 - form an octamer , the protein component of the nucleosome core particle , around which 147 basepairs of dna are wrapped .
one histone molecule of the linker or h1 class binds to the octamer near the point where the dna enters and exits the n... | in most eukaryotes , histones , which are the major structural components of chromatin , are expressed as a family of sequence variants encoded by multiple genes . because different histone variants can contribute to a distinct or unique nucleosomal architecture , this heterogeneity
can be exploited to regulate a wid... |
alpha-1 acid glycoprotein ( agp ; also known as orosomucoid ) is a 44 kda , heavily glycosylated protein synthesized primarily by hepatocytes and secreted into the plasma , where it circulates under normal conditions in humans at 830 m [ 1 , 2 ] . during the acute phase response ,
circulating levels of human agp ar... | alpha-1 acid glycoprotein ( agp ) is a highly glycosylated plasma protein that exerts vasoprotective effects .
we hypothesized that agp 's n - linked glycans govern its rate of clearance from the circulation , and followed the disappearance of different forms of radiolabeled human agp from the plasma of rabbits and m... |
uscaca is a non - exclusive organization that welcomes all who wants to volunteer time and effort to support cancer research and education .
the mission of uscaca is to facilitate collaborations among chinese and american professionals in the field of cancer research , treatment , and prevention ; promote knowledge a... | a global collaborative effort is pivotal to conquer cancer . themed emerging role of china in global clinical development of novel anti - cancer drugs
, the us chinese anti - cancer association ( uscaca ) held its 4th annual meeting in chicago on june 2 , 2012 , in conjunction with the american society of clinical o... |
differential diagnosis ( ddx ) includes malaria , typhoid fever , dengue fever , chikungunya fever , influenza and hepatitis a ( hav ) , , .
fever and chills suggest malaria , but may be present in dengue , chikungunya and influenza .
atypical lymphocytosis may be are present in malaria , dengue fever , chikungunya... | travelers returning from the tropics with fever remain a diagnostic challenge .
fever and chills suggest malaria , but may be present in dengue , chikungunya and influenza , and splenomegaly favors malaria or typhoid fever . in terms of laboratory tests , leukopenia suggests dengue fever , chikungunya fever or influe... |
to survive and adapt to their native surroundings , plants have developed mechanisms that detect and rapidly respond to assaults by both pathogens and arthropods .
plants recognize the plant - derived chemical , electrical , and hydraulic signals associated with wounding , as well as the chemical signals that are int... | the temporal and spatial expression of tomato wound- and defense - response genes to bemisia tabaci biotype b ( the silverleaf whitefly ) and trialeurodes vaporariorum ( the greenhouse whitefly ) feeding were characterized .
both species of whiteflies evoked similar changes in tomato gene expression .
the levels of... |
injection of botulinum toxin type a ( bont / a ) is a frequently administered aesthetic treatment for the reduction or prevention of hyperkinetic facial lines and rhytids .
however , since the introduction of bont / a to aesthetic medicine,1 studies evaluating the effects of this treatment have predominantly relied o... | background : quantitative numerical analysis of skin displacement triggered by muscles inserting the overlaying skin would be useful for monitoring the inhibition of mimetic muscles.methods:by using removable grid markings and digital photographs , skin displacement analysis ( sda ) was performed on 13 patients pre - t... |
in the treatment of osteoporosis , bisphosphonates have demonstrated their clinical efficacy , particularly their anti - fracture efficacy , and have become the most widely used anti - osteoporotic drugs worldwide .
the anti - fracture efficacy of ibandronate was first demonstrated in the bone study ( oral ibandronat... | the relationship between gains in bone mineral density ( bmd ) in the hip and the incidence of vertebral fractures in the mover study was examined .
japanese patients from the ibandronate and risedronate treatment groups whose hip bmd had increased during the 3-year treatment period were classified into those with or... |
the replication of genomic dna is a central event in the division and propagation of a bacterial cell .
the nucleoprotein complex responsible for dna replication is the replisome , which precisely coordinates the action of several discrete factors to efficiently and rapidly couple dna unwinding with high - fidelity n... | the replisome is a multi - component molecular machine responsible for rapidly and accurately copying the genome of an organism .
a central member of the bacterial replisome is dnab , the replicative helicase , which separates the parental duplex to provide templates for newly synthesized daughter strands . a unique ... |
corneal hydrops is a condition of acute stromal edema that occurs after a rupture in descemet 's membrane .
this is not an uncommon sequelae of late keratoconus and is a frequent indication for penetrating keratoplasty ( pkp ) .
approximately , 3% of keratoconus patients experience one or more episodes of corneal h... | a 44-year - old hispanic male and 91-year - old caucasian male presented to the clinic with acute vision loss and pain years after penetrating keratoplasty ( pkp ) .
neither patient had a history of keratoconus .
both patients had a history of eye rubbing and intraocular device present in the anterior chamber .
t... |
atrial standstill or silent atrium is a rare condition presenting with the absence of electrical and mechanical activity in the atria .
it presents with the absence of p waves , bradycardia , and wide qrs complex in the electrocardiogram ( ecg ) and has several substantially different etiologies , ranging from heredi... | we introduce a 32-year - old man who was evaluated for a dizziness and headache of unknown origin for at least two months and was referred to our center after ecg findings .
he was finally diagnosed as a case of idiopathic , familial , diffuse , persistent atrial standstill , which is a rare arrhythmogenic condition ... |
we studied 64 subjects divided into three groups matched for age and sex : 24 healthy nondiabetic subjects , 22 diabetic subjects with no clinical peripheral neuropathy , and 18 neuropathic diabetic subjects .
presence of diabetic peripheral neuropathy was determined according to standard clinical techniques as previ... | objectiveto investigate changes in the foot muscle energy reserves in diabetic non - neuropathic and neuropathic patients.research design and methodswe measured the phosphocreatinine ( pcr)/inorganic phosphate ( pi ) ratio , total 31p concentration , and the lipid / water ratio in the muscles in the metatarsal head reg... |
a number of bioceramic mixtures have been evaluated in terms of their ability to promote cellular attachment and induction of osteogenic differentiation .
there have been many reports of enhanced cellular bioactivity using biosilicates ( p2o5-na2o - cao - sio2),1 calcium - magnesium - silicate ceramics,2 calcium - si... | backgroundsilicon dioxide composites have been found to enhance the mechanical properties of scaffolds and to support growth of human adipose tissue - derived stem cells ( hadscs ) both in vitro and in vivo .
silica ( silicon dioxide alone ) exists as differently sized particles when suspended in culture medium , but... |
we studied the results of six patients operated on by the national university hospital ( nuh ) diabetic foot team in singapore between october 2011 and january 2012 .
there were four malays , one indian , and one chinese ranging in age 4767 , the average being 54 years old .
the diabetic foot infections were absces... | backgroundthis paper describes the surgical technique of a modified pirogoff 's amputation performed by the senior author and reports the results of this operation in a single surgeon case series for patients with diabetic foot infections.methodssix patients with diabetic foot infections were operated on by the nationa... |
acute coronary syndrome is rare in patients with hemophilia , potentially due to shorter lifespan or perhaps because of coagulation factor viii abnormality.1 ) hemophilia a directly protects against the development of coronary artery disease .
2)3 ) however , patients with hemophilia might not be protected against at... | patients with hemophilia generally have a reduced frequency of coronary artery disease compared to the general population . as advances in the management of hemophilia have increased their life expectancy , the prevalence of coronary artery disease also has increased . however , there are no standard treatment guidelin... |
central nervous system toxoplasmosis is a common opportunistic infection in immunocompromised patients especially in human immunodeficiency virus ( hiv ) positive patients .
involvement of spinal cord due to toxoplasmosis presenting as myelopathy is rarely seen in this era of antiretroviral therapy .
vacuolar myelo... | although brain has been the most common site for toxoplasma infection in acquired immunodeficiency syndrome patients , involvement of spinal cord by toxoplasma has been rarely found .
spinal cord toxoplasmosis can present as acute onset weakness in both lower limbs associated with sensory and bladder dysfunction .
... |
the rehabilitation of large bone defects may be achieved by different types of grafting materials , from natural or synthetic origin .
autologous grafting is the option exhibiting the highest success rate . despite of its several advantages ,
this grafting type may cause the morbidity of the donor area , increase t... | autologous bone is reported by scientific literature as the gold standard for the replacement of the bone loss in maxillary atrophic area .
notwithstanding , this grafting type shows several disadvantages as : the procedure morbidity , limited size of the graft and longer recovering time . recombinant human bone
mo... |
we restricted our analyses to peridomestic cases that were reported in the geographic region previously determined to be at high risk on the basis of environmental factors ( 6 ) .
thus , we included 123 ( 75.9% ) of 162 cases reported in new mexico during the study period .
we also restricted our analyses to the cb... | plague , a rare but severe disease spread by rodents and fleas , has been traditionally associated with poor , unsanitary living conditions . to test this association ,
researchers in new mexico used census data to determine the geographic and socioeconomic status of plague patients . although they confirmed that mos... |
kumar1 claimed that people have
difficulty using the hamstrings , muscles that are prone to shortening .
ayala2 argued that the hamstrings play a
significant role in effective walking and running , and that short hamstrings have often been
observed in people , especially athletes . in addition , extended hamstr... | [ purpose ] this research explored the positive effects of self - myofascial release on
hamstring muscular flexibility and proprioception and investigated the effectiveness of
the stretch combined with therapeutic ultrasound . [ subjects and methods ] this study
included 30 healthy university students with no his... |
venolymphatic malformations ( vlms ) are tumor - like lesions combining dysplastic lymphatic and venous vessel structures .
the international society for the study of vascular anomalies has divided vascular lesions into hemangiomas and vascular malformations ( vms ) .
hemangiomas are characterized by rapid growth i... | vascular malformations ( vms ) are structural malformations of vascular development causing soft tissue abnormality with functional and esthetic impairment .
they are named by their predominant vessel type as arterial , venous , lymphatic or mixed types .
vms of the parotid gland are extremely rare and constitute a... |
ultrafast laser technology in the last two decades progressed to the point
where heterodyne - detected four wave mixing ( fwm ) experiments can fully
characterize the third - order optical response .
in such experiments , three excitation pulses , separated by two time
delays t1 and t2 , induce a coherent signa... | center line slope ( cls ) analysis
in 2d infrared spectroscopy has been extensively used to extract frequency
frequency
correlation functions of vibrational transitions .
we apply this concept
to 2d electronic spectroscopy , where cls is a measure of electronic
gap fluctuations .
the two domains , infrare... |
bladder cancer ( bca ) was estimated to be the seventh most common type of cancer worldwide in 2009 . in poland ,
bca was the third most frequent malignant tumor in men and thirteenth in women in 2009 .
etiology of bca includes environmental factors such as exposure to tobacco smoke , occupational exposure , and ge... | introductionbreakdown of the extracellular matrix by matrix metalloproteinases ( mmps ) , as we know , is one of mechanisms involved and required in tumor invasion .
mmp7 is a negative prognostic factor of various malignances , while mmp8 exhibits an inhibitory effect on tumorigenesis and metastasis .
we evaluated ... |
the index patient ( patient b2 - 1 ) was a 47-year - old woman , and patient b3 - 1 was her 29-year - old daughter ( figure 1 ) . both were investigated and followed at the neurology outpatient clinic of turku university hospital .
the father of patient b2 - 1 was diagnosed with pd at age 52 and died at age 63 .
th... | objective : to describe the clinical features and brain imaging findings of autosomal dominant parkinson disease ( pd ) associated with a recently reported mutation in snca.methods:a finnish family with pd in 3 successive generations , in accordance with an autosomal dominant inheritance pattern , was identified .
we... |
respiratory resistance is proportional to the total opposition to breathing caused by frictional forces in the airway passages . at any given time , respiratory resistance is equal to the ratio of respiratory pressure to airflow , given by
( 1)rres=presv ,
where rres is respiratory resistance , pres is the respirat... | the airflow perturbation device ( apd ) has been developed as a portable , easy to use , and a rapid response instrument for measuring respiratory resistance in humans .
however , the apd has limited data validating it against the established techniques .
this study used a mechanical system to simulate the normal r... |
upon recognition of hepatitis c virus ( hcv ) infection by toll - like receptor 3 ( tlr3 ) and retinoic - acid inducible gene i ( rig - i ) , the innate immune response is promptly activated in hepatocytes .
the two pattern recognition receptors ( prrs ) recruit their respective adaptors , toll / interleukin-1 recept... | aim . to gain an insight into the effect of hcv replication - associated interference with the ifn system on hepatic mrna expression involved in ifn production
. methods .
relative mrna expression of tlr3/rig - i signaling genes involved in ifn- production was correlated with positive- and negative - strand hcv rna... |
congenital hypothyroidism ( ch ) is the most common congenital endocrine disorder in childhood which is associated with irreversible neurological problems and poor growth in untreated individuals . in europe and north america ,
1 in 3,000 to 4,000 newborns is affected by this disease [ 1 , 2 ] . in the majority of pa... | background . thyroid peroxidase gene ( tpo ) mutations are one of the most common causes of thyroid dyshormonogenesis in patients with congenital hypothyroidism ( ch ) . in this study ,
the prevalence of tpo gene mutations in patients with thyroid dyshormonogenesis in isfahan was investigated . methods . in this cros... |
a true aneurysm of the inferior thyroid artery ( ita ) is extremely rare15 ) . despite its rarity ,
several authors have recommended aggressive management because the lesion has the potential to be highly lethal4 ) .
surgical ligation and/or excision and endovascular embolization were reported as possible treatment... | we present a unique experience of urgent parent arterial embolization for treatment of an aneurysm of the inferior thyroid artery ( ita ) that bled during tracheostomy .
the event happened to a 69-year - old female patient with subarachnoid hemorrhage and hospital - acquired pneumonia that required tracheostomy .
a... |
the half - life of knowledge in the medical fields is estimated to be between five and seven years .
providers who do not conscientiously pursue a programme to maintain state - of - the - art practice could lose half of their competence in that period of time .
this implies that the information base upon which clin... | backgroundit is hard to imagine any period in time when economic issues were more visible in health sector decision - making .
the search for measures that maximize available resources has never been greater than within the present decade .
a staff payroll represents 60%-70% of budgeted health service funds .
the... |
shoulder pain is one of the most common complaints encountered in patients with rheumatoid arthritis ( ra ) . during the first 2 yr of ra , nearly 50% of patients have shoulder symptoms , and 90% complain of shoulder pain at some time during the course of the disease ( 1 ) .
in addition to the synovitis of the glenoh... | the objectives of this study were : 1 ) to identify the ultrasonographic ( us ) abnormalities and 2 ) to compare the findings of physical examination with us findings in rheumatoid arthritis ( ra ) patients with shoulder pain .
we studied 30 ra patients .
physical examination was performed systemically as follows :... |
bacillus calmette - gurin ( bcg ) is an attenuated strain of mycobacterium bovis [ 1 , 2 ] .
since bcg is usually considered to be avirulent , it is used for vaccination against tuberculosis in japan for infants . on the other hand ,
a previous report suggested that delayed granuloma formation could develop at the ... | since bacillus calmette - gurin ( bcg ) is an attenuated strain of mycobacterium bovis , lupus vulgaris ( lv ) is reported as one of the rare complications after bcg vaccination , correlating with immunosuppression in the lesional skin . in this report
, we describe a case of lv arising from the bcg vaccination site ... |
we obtained the full - length genome sequence for a / duck / nigeria/3724 - 2/2008 and the sequence of the hemagglutinin ( ha ) segment for a / duck / nigeria/3724 - 10/2008 ( 4 ) .
sequences of the 8 gene segments of a / duck / nigeria/3724 - 2/2008 were submitted to the global initiative on sharing avian influenza ... | genetic characterization of highly pathogenic avian influenza viruses ( h5n1 ) isolated in july 2008 in nigeria indicates that a distinct genotype , never before detected in africa , reached the continent .
phylogenetic analysis showed that the viruses are genetically closely related to european and middle eastern in... |
the progressive development in the field of information and communication technology ( ict ) during the last decades has led to great advances also in the health sector ( e - health ) .
there is a global , regional , and national awareness about the importance of e - health . the world health organization ( who ) mil... | information and communication technology ( ict ) is progressively used in the health sector ( e - health ) , to provide health care in a distance ( telemedicine ) , facilitate medical education ( e - learning ) , and manage patients ' information ( electronic medical records , emrs ) .
gezira family medicine project ... |
orthorexia nervosa , literally meaning proper appetite , is a pathological fixation with healthy food that has aptly been described as
a disease disguised as a virtue.1 although not yet officially recognized as a psychiatric diagnosis , orthorexia is often associated with significant impairment , as what starts as ... | orthorexia nervosa describes a pathological obsession with proper nutrition that is characterized by a restrictive diet , ritualized patterns of eating , and rigid avoidance of foods believed to be unhealthy or impure .
although prompted by a desire to achieve optimum health , orthorexia may lead to nutritional defic... |
the feedback [ table 1 ] from the relative who attended the squint surgery was obtained by a trained secretary .
the feedback was taken in their native language , preferably on the first follow - up visit , in the opd ( same evening or second postoperative day ) or by a telephonic call at their convenient time , in t... | the aim of the study was to know the response of the relatives attending the squint surgery of their ward .
a trained secretary administered an eight item questionnaire by live / telephonic interview .
of the 44 attendees , two left the operation theater before completion of the surgery .
mean age of the patients... |
some unusual renal tumors like clear cell sarcoma kidney ( ccsk ) , rhabdoid tumor kidney ( rtk ) , congenital mesoblastic nephroma ( cmn ) , multilocular cystic nephroma ( mcn ) , teratoid wilms , and renal teratomas are found infrequently .
they are usually diagnosed by tissue biopsy in the form of histopathologica... | aims : scrutiny over the clinical behaviors , management , and the final outcome of some rare renal neoplasm in order to find out some hidden facts about these tumors which are playing an important role in the disease course and its management.materials and methods : retrospective evaluation of uncommon ( non - wilms )... |
several studies assessing the adverse effects of sepsis on the heart have shown that myocardial dysfunction is a common , severe complication of sepsis , and the mechanisms responsible for development of myocardial dysfunction are complex .
hemodynamic monitoring is important in the management of critically ill sepsi... | this article was to review the literature regarding the use of the pulmonary artery catheter ( pac ) in the management of patients with sepsis and septic shock .
a pubmed search was conducted in order to identify publications evaluating the use of pac as a tool for management and therapeutic guidance in patients with... |
neonatal diabetes mellitus ( ndm ) is a rare endocrinological disorder , which affects children in the first 6 months of life , with estimated incidence of 1/90,000 to 1/210,000 live births 1 , 2 .
two forms of this condition have been identified , transient and permanent neonatal diabetes mellitus ( tndm and pndm ) ... | key clinical messagediabetes mellitus is rare during infancy , however , it should be suspected in infants presenting with features consistent with sepsis and hyperglycemia .
this is crucial in initiating the treatment of diabetes ketoacidosis which if delayed may result in significant morbidity and death . |
a 17-month - old boy weighing 14 kg was diagnosed with a fracture of the right lateral humeral condyle and scheduled for open reduction and internal fixation with a kwire .
he had suffered from an upper respiratory infection for the previous 3 weeks and drug - induced hepatitis developed as a result of his medication... | the interscalene brachial plexus block is not commonly used in pediatric regional anesthesia .
the increasing popularity of ultrasound has allowed more anesthesiologists to perform regional anesthesia with high success rates in pediatric patients with the direct visualization of the target nerve and spread of local a... |
hydrocephalus occurs if the production of cerebrospinal fluid ( csf ) exceeds its resorption , and this leads to elevated intracranial pressure .
it often requires surgical treatments such as repetitive lumbar punctures or a ventriculoperitoneal ( vp ) shunt to reduce the intracranial pressure and avoid compression o... | objectivethe aim of this study is to determine the association between the cerebrospinal fluid ( csf ) biomarkers and inflammation , and the predictive value of these csf biomarkers for subsequent shunt associated infection.methodswe obtained csf samples from the patients with hydrocephalus during ventriculoperitoneal ... |
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