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regulation of nuclear protein transportation through nuclear pore complexes ( npcs ) is an essential function in eukaryotic cells .
most macromolecules larger than 4060 kda are transported actively through the npc mediated by transport factors such as members of importin- superfamily ( fabre and hurt 1994 ; davis 19... | imp13 , a member of importin- superfamily , is found to be one of two bidirectional transport receptors in many nuclear transport activities in mammals .
several cargoes of imp13 have been identified ; most of these are essential factors involved in cell cycle and development .
the expression and localization of im... |
complete esophageal obstruction ( ceo ) is an uncommon phenomenon characterized by lumen obliteration that can arise from both benign and malignant etiologies .
the former , being more frequent , is commonly the result of chemoradiation therapy of head and neck and lung cancers .
however , incidence is dose - depen... | background and study aims : complete esophageal obstruction ( ceo ) is a rare occurrence characterized by progressive esophageal stricture , which eventually causes lumen obliteration . with recent advances in flexible endoscopy ,
various innovative techniques exist for restoring luminal continuity.the primary aim of... |
bone marrow transplantation ( bmt ) from an hla - matched related donor is the treatment of choice for children and young adults with severe aplastic anemia ( saa ) .
patients without an appropriate sibling donor usually receive immuno - suppressive therapy , and those who fail it , undergo bmt from an hla - matched ... | severe aplastic anemia ( saa ) patients without an hla - matched sibling donor need alternative treatment options . umbilical cord blood transplantation ( ucbt )
has become an alternative means for treating various diseases , but it has not been proved to be a satisfactory method to treat saa . here , we report the c... |
ocular symptoms in behet s disease ( bd ) begin mostly before 30 years of age according to international surveys , and bd activity may decrease with age .
anti - tnf antibody has recently demonstrated strong effects against recurrent uveitis in bd , but the efficacy and safety of anti - tnf therapy in elderly patient... | backgroundocular symptoms in behet s disease ( bd ) begin mostly before 30 years of age according to international surveys , and bd activity may decrease with age .
information regarding the treatment of ocular symptoms in elderly bd patients is thus scant .
anti - tnf antibody has recently demonstrated strong effe... |
although the hippocampus has not typically been identified as part of the neuronal circuit for language and aphasia , recent evidence suggests that the hippocampus is closely related to naming , word priming , and anomic aphasia .
we present herein a case that presented with limbic encephalitis ( le ) , bilateral sym... | although the hippocampus has not typically been identified as part of the language and aphasia circuit , recent evidence suggests that the hippocampus is closely related to naming , word priming , and anomic aphasia . a 59-year old woman with limbic encephalitis of possible autoimmune etiology , after recovery of consc... |
national health and wellness survey ( nhws ; n = 75,000 ) , an annual , cross - sectional study of the u.s . adult ( aged 18 years ) population . a stratified random sample ( with strata by gender , age , and ethnicity ) was implemented to ensure that the demographic composition of the sample was aligned to that of t... | objective : the aim of this study was to evaluate the association of mental well - being with outcomes among patients with type 2 diabetes mellitus ( t2dm).methods : seven thousand eight hundred fifty - two adults with t2 dm were identified from a national , internet - based study . mental well - being [ sf-36v2 mental... |
according to barker 's theory , certain risk exposures few months before pregnancy , during pregnancy , and in early childhood might have a role in the occurrence of some disorders in adulthood .
it is , therefore , essential to monitor the medical status of neonates , particularly those at certain risks , to keep th... | background .
a follow - up program for high risk infants was initiated in alzahra maternity hospital in tabriz city , iran , in 2013 .
the aim of this paper is to give a brief report of the program .
material and methods .
two groups of high risk neonates were studied .
the first group comprising 509 infants ... |
members of this genus growing at temperatures between 35 and 75 c are widespread throughout the world and can be recovered from various natural environments with temperatures ranging from 80 c to that of glacier ice ( such as hot springs , petroleum reservoirs , compost , marine hydrothermal vents , soils , lake a... | the draft genome sequence of geobacillus sp .
strain 1017 , a thermophilic aerobic oil - oxidizing bacterium isolated from formation water of the dagang high - temperature oilfield , china , is presented here .
the genome comprised 3.6 mbp , with the g + c content of 51.74% .
the strain had a number of genes r... |
pityriasis rubra pilaris ( prp ) is a rare chronic inflammatory keratosis , clinically characterized by gradually developing to reddish or orange extending plaques and keratotic follicular papules .
five types of prp were classified by griffith , and there are refractory cases ( particularly in type ii ) in contrast ... | pityriasis rubra pilaris ( prp ) is a rare chronic inflammatory keratosis that is clinically characterized by gradually developing reddish or orange extending plaques and keratotic follicular papules . in pediatric patients ,
we frequently hesitate to administer certain medications for treatment of prp , specifically... |
individual identification is an important and challenging task in forensic investigation , which was based on scientific principles .
tsuchihashi and suzuki established that the arrangement of lines on the red part of the human lip is individual and unique .
the grooves were named as sulci labiorum and correspondin... | background : in forensics , the mouth allows for a myriad of possibilities .
lip print on glass or cigarette butt found at crime scenes may link to a suspect .
hence , a dentist has to actively play his role in personal identification and criminal investigation.aims:to investigate the uniqueness of the lip print pa... |
traumatic distraction injuries to the craniocervical junction are typically treated with occipitocervical fusion procedures.1
2
3 high failure rates of nonoperative management have been reported.4 the existing literature includes few reports of craniocervical injuries treated successfully with prolonged immobilizat... | study design literature review and case report .
objective review the existing literature and report the successful nonoperative management of a two - level craniocervical ligamentous distraction injury .
methods a pubmed and medline review revealed only three limited reports involving the nonoperative managemen... |
as reported in the previous issue of critical care , vincent and colleagues investigated the possible increased risk of patients with insulin - treated diabetes for morbidity and mortality in the intensive care unit ( icu ) .
literature is conflicting at this point , with studies showing increased risk , decreased ... | diabetes is associated with severe complications and decreased life expectancy . however , in the previous issue of critical care , vincent and colleagues report no difference in mortality between patients with insulin - treated diabetes and patients without diabetes in the intensive care unit ( icu ) , despite larger ... |
missing values are endemic across health and social studies.1 ) missing data reduce statistical power and representativeness of the sample and might cause misinterpretation of the results by introducing bias.2 ) socioeconomic status ( ses ) variables such as education , income , marital status , and occupation are ofte... | this study is to assess how missing values in socioeconomic status ( ses ) variables were handled in the korean journal of family medicine ( kjfm ) article using the korea national health and nutrition examination survey ( knhanes ) data and to estimate the rate of missing ses variables from the 4th knhanes .
we sear... |
mass spectrometric analysis of proteome
samples from eukaryotic
cell lines , tissues or biological fluids is still hampered by the
vast complexity of samples and concentration differences of proteins
within making comparisons of proteomics and transcriptomics data difficult .
online and off - line two - dimen... | due to its compatibility and orthogonality to reversed
phase ( rp )
liquid chromatography ( lc ) separation , ion exchange chromatography ,
and mainly strong cation exchange ( scx ) , has often been the first
choice in multidimensional lc experiments in proteomics . here , we
have tested the ability of three ... |
the markhor ( capra falconeri ) is an endangered wild goat in a continuous decline ; the global population is < 2,500 mature animals ( 5 ) . in tajikistan , < 350 animals may survive in fragmented subpopulations in the remote hazratishoh and darvaz mountain ranges along the afghanistan border ( 6 ) .
they live sedent... | a pneumonia outbreak reduced the numbers of a wild population of endangered markhors ( capra falconeri ) in tajikistan in 2010 .
the infection was diagnosed by histologic examination and bacteriologic testing .
mycoplasma capricolum subsp .
capricolum was the sole infectious agent detected .
cross - species tra... |
all of the subjects underwent a comprehensive ophthalmologic examination , which included best - corrected visual acuity ( bcva ) ; slit - lamp biomicroscopy ; refraction measurement using auto refraction , calculation of the spherical equivalence ( se ) based on the spherical diopter ( d ) plus one - half of the cylin... | purposeto investigate the relationship between retinal perfusion and retinal thickness in the peripapillary and macular areas of healthy subjects.methodsusing spectral - domain optic coherence tomography and split - spectrum amplitude decorrelation angiography ( ssada ) algorithm , retinal perfusion and retinal thickne... |
atypical prostatic hyperplasia ( aph ) is a pseudoneoplastic lesion that can mimic prostate adenocarcinoma because of its architectural and cytological features . in this prostatic disease , there is an imbalance between prostate cell growth and apoptosis .
the occurrence rate of aph is not known and its associations... | red onion scales ( ros ) contain large amounts of flavonoids that are responsible for the reported antioxidant activity , immune enhancement , and anticancer property .
atypical prostatic hyperplasia ( aph ) was induced in adult castrated wistar rats by both s.c .
injection of testosterone ( 0.5 mg / rat / day ) a... |
the honey bee insect belongs to the order hymenoptera of the family apidae of the genus : apis , subordinated by the western honey bee apis mellifera jemenatica ruttner that has spread out all around the earth .
it is in several geographical areas and spaced eras , and such isolation has resulted in a large number of... | introductionhoneybees are constantly exposed to a wide range of vital and non - vital pressures that may interact with each other and affect the health or survival of the insects .
pesticides are the main danger for the insects , and they subsequently have impacts on human and environmental health.methodsfield resear... |
it is one of the most common gynecological disorders in the reproductive age women and its prevalence in the general population varies between 0.7 and 44% .
endometriosis is usually found in the pelvis and especially the ovaries , uterosacral ligaments , and round ligaments . on the other hand , it is observed in ext... | endometriosis is defined as the presence of functioning endometrial tissue outside the uterine cavity .
this disease is one of the most common gynecologic disorders in reproductive age women .
it generally occurs in pelvic cavity .
but extrapelvic location has been defined ( such as extremities , central nervous ... |
dentigerous cyst is a type of odontogenic cysts and has a rate between 20% and 24% in all the jaw cysts .
these cysts form between the enamel epithelium and the enamel of the crown of the affected tooth , and the fluid accumulation occurs in the related area .
dentigerous cyst always includes the crown of an unerup... | dentigerous cyst is a type of odontogenic cysts and generally occurs in the ages of twenties or thirties .
dentigerous cyst always includes a tooth which can not complete the eruption process and occurs around the crown by the fluid accumulation between the layers of enamel organ . in rare cases ,
dentigerous cyst ... |
in this issue of critical care , carlier and colleagues describe pharmacokinetic / pharmacodynamic ( pk / pd ) target attainment in critically ill patients receiving meropenem or piperacillin / tazobactam as extended infusions .
these investigators found that 48% of patients did not achieve the desired pk / pd target... | critically ill patients with infection provide a number of challenges to clinicians in terms of optimizing their antimicrobial treatment . of foremost importance
, initial antibiotic treatment should be selected as to provide coverage for the causative pathogens .
however , the administration of those antibiotics (... |
malignant neoplasm of lymphoid cell is lymphomas which is divided into 2 groups : hodgkin and non - hodgkin .
primarily hodgkin 's lymphoma is lymph nodes 's disease , which has been known with the presence of two nuclear cells called reed - sternberg cells and lymphoid stroma composed of many non - neoplastic cells ... | lymphoma is a malignant neoplasm of lymphoid tissue which is divided into 2 groups : hodgkin and non - hodgkin .
about 85% of non - hodgkin lymphomas are b - cell lymphomas , and t - cell lymphomas are unusual .
anaplastic large cell lymphoma ( alcl ) is a kind of non - hodgkin lymphoma with t or nk cell origin tha... |
the majority of the studies of the neuropathology of mci , especially degenerative / amnestic mci , suggest that in most instances mci is associated with a less fervent manifestation of the neuropathologies that are generally associated with dementia .
unselected mci samples derived from memory clinic or general geri... | the number of studies that have investigated the neuropathology of mild cognitive impairment ( mci ) is small , but growing . in this paper
we have restricted our focus to the consideration of the presence and extent of postmortem findings relevant to the neuropathology of alzheimer 's disease .
we have drawn from ... |
the portability of a handheld dynamometer ( hhd ) is excellent , and its clinical application
for measurements is simple .
the relative intra - class and inter - class reliabilities of an hhd
are 0.840.991 and 0.840.942 , respectively .
conventionally , the sensor
unit of an hhd is fixed during the measuremen... | [ purpose ] the aim of this study was to verify the absolute reliability of shoulder joint
horizontal adductor muscle strength measurements using a handheld dynamometer ( hhd ) .
[ subjects and methods ] the subjects were 33 healthy college students .
the measurements
were made three times with the hhd fixed us... |
chylous ascites is considered a relatively rare postoperative complication , but it can not be disregarded because van der gaag et al . 1 reported that the incidence after pancreaticoduodenectomy was 9% , and malik et al .
2 reported that it was 6.7% . for treatment , there are conservative and surgical treatments ... | key clinical messagetherapeutic lipiodol lymphangiography for postoperative chyle leakage due to lymph duct damage has recently been attracting attention .
lymph duct puncture is technically complex and difficult .
lymphangiography and sclerotherapy can be easily applied by cannulation with a catheter for the neona... |
allergic asthma is a complex disease characterized by eosinophilic pulmonary inflammation , mucus production and reversible airway obstruction1 .
exposure to indoor allergens is a clear risk factor for asthma , but this disease is also associated with high household levels of total and gram - negative bacteria2 . the... | |
with the obvious increasing prevalence and mortality rate , cancer has become one of the primary causes of morbidity and mortality . the underlying mechanisms of the tumorigenesis are obscure because of the involvement of multiple risk factors containing complicated gene - gene and gene - environment interactions .
m... | backgroundmany epidemiology studies have indicated that several functional polymorphisms of the il-27 gene may contribute to individual susceptibility to cancer . nevertheless , the data arising from these studies were inconclusive .
therefore , we conducted the current meta - analysis aiming to elucidate the effects... |
the concept of preimplantation genetic screening ( pgs ) for chromosomal abnormalities to improve clinical outcomes in patients undergoing in vitro fertilization ( ivf ) is based on the observation that aneuploidy represents the leading genetic cause of miscarriage and is likely the most prevalent genetic abnormality... | preimplantation aneuploidy screening of cleavage stage embryos using fluorescence in situ hybridization ( fish ) may no longer be considered the standard of care in reproductive medicine . over the last few years
, there has been considerable development of novel technologies for comprehensive chromosome screening ( ... |
in denmark , women planning to conceive are advised to take a daily supplement of 400 g folic acid ( fa ) until the 12th week of gestation to reduce the risk of neural tube defects ( ntds).1 starting fa supplementation before conception is an important component of effective prevention of ntds , since the neural tube c... | purposecompliance with the danish preconceptional folic acid ( fa ) recommendation a daily supplement of 400 g is reported to be poor .
uncertainty remains , however , about the prevalence of compliers and health - related predictors of compliance in the preconceptional period.methodswe used self - reported baselin... |
villous adenomas are common lesions of the gastrointestinal tract but they are rarely located in the urinary tract including the bladder .
. they should be accepted as important lesions because the malignancy potential of them is still not known [ 1 , 2 ] . here
a 43-year - old male patient was admitted to our hosp... | villous adenomas are common lesions of the gastrointestinal tract but they are rarely located in the urinary tract including the urinary bladder .
there are a few case reports and series in the literature . here
we report a 43-year - old male patient who had a polypoid lesion located on the left lateral wall of the... |
primary neuroendocrine cancer of the bladder is a rare histological occurrence , constituting 0.48 - 1% of all bladder cancers .
the 5-year survival rate is around 8% and the prognosis is extremely unfavorable . due to the morphology of the tumor , treatments based on small cell lung cancer
, we treated a case in w... | the case was a 67-year - old male who visited our hospital with a major complaint of macroscopic hematuria . a bladder tumor was found . when a transurethral resection of the bladder tumor was performed , the histopathological diagnosis was neuroendocrine bladder cancer .
after chemotherapy with cisplatin and etoposi... |
intensive care unit ( icu ) admission in chronic obstructive pulmonary disease ( copd ) patients is generally due to infections by bacterial or viral agents , but fungal agent may occur in immunocompromised states . among fungal agents
candida is the most common species , of which a new fluconazole resistant strain o... | chronic obstructive pulmonary disease ( copd ) exacerbations admitted in intensive care units ( icus ) occur rarely due to fungal respiratory tract infections , but may occur when associated co - morbidities like diabetes mellitus coexist .
candida ciferrii is a new agent , recently was isolated from lung infections ... |
tumorigenesis is a multistep process beginning with the transformation of a single cell by the accumulation of at least six distinct characteristics .
these include infinite lifespan , resistance to antigrowth signals , resistance to apoptosis , autocrine production of growth signals , sustained angiogenesis , and ti... | a critical step in the transformation of cells to the malignant state of cancer is the induction of mutations in the dna of cells damaged by genotoxic agents
. translesion dna synthesis ( tls ) is the process by which cells copy dna containing unrepaired damage that blocks progression of the replication fork .
the ... |
we examined associations between low - level exposure to ionizing radiation and mortality among 14,095 workers hired at the oak ridge national laboratory between 1943 and 1972 .
workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascer... | |
ten subjects ( four female , six male ) with type 2 diabetes treated by diet and/or metformin were recruited ( aged 61 2.3 years , waist - to - hip ratio 0.96 0.01 , bmi 28.8 1.0 kg / m , body fat 33.4 2.6% , and a1c 6.7 0.1% ) .
every subject was studied on 2 separate days in random order with 24 week intervals... | objectiveto evaluate the effect of a prebreakfast high - protein snack upon postbreakfast hyperglycemia.research design and methodswe studied 10 men and women with diet- and/or metformin - controlled type 2 diabetes .
metabolic changes after breakfast were compared between 2 days : breakfast taken only and soya - yog... |
progress in diabetes care over the last decade , such as the routine use of recombinant insulins , continuous subcutaneous insulin infusions , and continuous glucose monitoring , has improved and lengthened the lives of millions of patients . as patients live longer they are more likely to develop impaired awareness of... | currently available -cell replacement therapies for patients with diabetes , including islet and pancreas transplantation , are largely successful in restoring normal glucose metabolism , but the scarcity of organ donors restricts their more widespread use . to solve this supply problem ,
several different strategies... |
dna damage tolerance enables a cell to resolve replication problems such as damage - induced fork stalling ( lawrence , 1994 ; lehmann , 2002 ; ulrich , 2005 ) .
replicative bypass of dna lesions occurs via translesion synthesis ( tls ) by specialized damage - tolerant dna polymerases or by an error - free damage avo... | summaryreplicative dna damage bypass , mediated by the ubiquitylation of the sliding clamp protein pcna , facilitates the survival of a cell in the presence of genotoxic agents , but it can also promote genomic instability by damage - induced mutagenesis .
we show here that pcna ubiquitylation in budding yeast is act... |
dapagliflozin , a member of sodium - glucose cotransporter-2 ( sglt2 ) inhibitors family , exhibits glucose - lowering effect in patients with t2 dm [ 1 , 2 ] .
treatment with dapagliflozin has been shown to improve glycemic control and reduce body weight and systolic blood pressure ( sbp ) [ 38 ] without increase in... | objectives . to observe changes in blood glycemic variations and oxidative stress level before and after dapagliflozin treatment in patients with newly diagnosed t2 dm . methods .
this was a randomized , double - blind , placebo - controlled , phase 3 trial .
a total of 28 patients with newly diagnosed t2 dm with h... |
septic acute kidney injury ( aki ) is associated with poor outcome compared to septic patients without aki , hence sepsis is regarded as the most common trigger of aki in seriously ill patients .
sepsis leads to aki in ~50% of all critically ill patients.1 there are various other studies that reported that 40%75% cas... | backgroundsepsis is the most common cause of acute kidney injury ( aki ) .
very few studies have investigated the predictive properties of urinary neutrophil gelatinase - associated lipocalin ( ungal ) as a marker of aki in septic patients .
the aim of this study is to examine ungal in septic patients with and with... |
necrotizing fasciitis / fournier s gangrene is a rare , life - threatening soft tissue infection that can rapidly progress to systemic toxicity if not treated promptly .
its aetiology is poorly understood , and it can often be triggered by a very minor inciting event , such as an insect bite or minor trauma .
early... | we report a rare case that highlights acute pancreatitis as the protagonist of fournier s gangrene . this patient was treated with a radical debridement of his perineum at presentation and
subsequently reconstructed with split thickness skin grafting .
this is an unusual aetiology of necrotizing fasciitis with only... |
in the last few years , a new class of highly conserved ~21-mer non - coding rnas , micrornas ( mirnas ) , has emerged as an important player in post - transcriptional gene expression control in different physiological and pathological conditions : metabolism , proliferation , cell death , differentiation and developme... | micrornas ( mirnas ) are highly conserved 22-mer rna molecules , encoded by plants and animals that regulate the expression of genes binding to the 3-utr of specific target mrnas .
the amount of mirnas in a total rna sample depends on the recovery efficiency that may be significantly affected by the different purific... |
the recent development of engineered humanized monoclonal antibodies has increased their therapeutic efficacy and decreased their toxicity , expanding their potential for the treatment of cancer .
tumors of epithelial origin , among which we have head and neck cancers , are one of the leading causes of death worldwid... | nimotuzumab , an igg that recognizes the epidermal growth factor receptor ( egf - r ) overexpressed in some tumors , is used in the treatment of advanced head and neck cancer . for the quantification of this protein in cell culture supernatants , protein g - hplc affinity chromatography
is used due to its high affini... |
psychotic disorders and schizophrenia are disabling conditions characterized by positive symptoms , negative symptoms , and cognitive impairments .
most individuals with schizophrenia have a poor long - term outcome resulting in personal suffering and psychosocial disabilities including impaired interpersonal and voc... | compliance and relapse are major issues in the treatment of psychotic disorders .
about 50% of subjects with schizophrenia do not comply with treatment and relapse rates of 65% are reported after one year and 80% after two years .
drug treatments are effective against psychotic symptoms , but can not promote functi... |
recently , the use of water soluble fluorescent conjugated polymers ( cps ) as either chemical or biological sensing elements has received wide interest [ 15 ] .
cps contain a large number of absorbing and delocalized molecular units , and the transfer of excitation energy along the whole backbone of the cp to the en... | water - soluble fluorescent conjugated polymer is a promising material which could be used as an optical platform in highly sensitive molecular sensors . in this paper , a simple label - free dna sensor , which consisted of a poly(3-alkoxy-4-methylthiophene ) and an aptamer ,
was used to detect l - argininamide ( l -... |
attempts to minimize this include minimal tumor manipulation prior to ligation of the venous drainage .
laparoscopy has become a standard option for the management of adrenal tumors . in cases of pheochromocytomas ,
most surgeons prefer to use the transperitoneal approach , with the belief that it affords a better ... | objectives : to evaluate the feasibility of the retroperitoneoscopic approach to adrenalectomy for pheochromocytoma and to compare it with the open retroperitoneal approach.methods:twelve retroperitoneoscopic adrenalectomies for pheochromocytomas were performed in 10 patients at our center between january 1996 and janu... |
spirituality is associated with mental health , managing substance abuse , marital functioning , parenting , and coping .
it has been suggested that spirituality also leads to finding purpose and meaning in life .
this article focuses on the karma yoga described in bhagavad gita and its meaning in relation with pos... | karma yoga is the path that leads to salvation through action .
salvation is the ultimate state of consciousness .
work is the central and defining characteristic of life .
it may have intrinsic value , instrumental value , or both .
instrumental value includes incentive , dignity and power , etc . , which is t... |
especially , by modifying the surface properties of mechanical roughness , osteogenesis ability of the implant is enhanced .
not only topography but also chemistry of the tio2 surfaces affect cellular attachment , proliferation , osteoblastic activity , differentiation , and formation of mineralized nodules on the su... | purposethis study focused on in vitro cell differentiation and surface characteristics in a magnesium coated titanium surface implanted on using a plasma ion source.materials and methods40 commercially made pure titanium discs were prepared to produce ti oxide machined surface ( m ) and mg - incorporated ti oxide machi... |
fossil records and molecular data suggest that am symbiosis is evolutionary ancient and that it occurred with the first terrestrial plants .
however , species diversity of amf is low , with only approximately 240 recognized species [ 3 , 5 ] , although molecular studies have suggested the existence of a significantly... | arbuscular mycorrhizal fungi ( amf ) have mutualistic relationships with more than 80% of terrestrial plant species .
this symbiotic relationship is ancient and would have had important roles in establishment of plants on land . despite their abundance and wide range of relationship with plant species ,
amf have sh... |
access to zinc is essential for organisms throughout the three domains of life . it is the only metal that occurs as a cofactor in all six classes of enzymes , from oxido - reductases to lyases ( 1 ) , and the average proportion of enzymes containing zinc is 8.8% in eukaryotic proteomes ( 2 ) . in pathogens ,
virulen... | the supply and intracellular homeostasis of trace metals are essential for every living organism .
therefore , the struggle for micronutrients between a pathogen and its host is an important determinant in the infection process . in this work ,
we focus on the acquisition of zinc by candida dubliniensis , an emergi... |
amyotrophic lateral sclerosis ( als ) is a rapidly progressive neurodegenerative disease that primarily affects upper and lower motor neurons , resulting in death three to five years after symptom onset in the majority of patients ( 1 ) .
the pathomechanism of als is largely unknown , but research efforts have been f... | to evaluate the efficacy and safety of ursodeoxycholic acid ( udca ) with oral solubilized formula in amyotrophic lateral sclerosis ( als ) patients , patients with probable or definite als were randomized to receive oral solubilized udca ( 3.5 g/140 ml / day ) or placebo for 3 months after a run - in period of 1 month... |
regional anesthesia techniques provide important advantages including excellent pain control , reduced side - effects , and shortened stay in the post anesthesia care unit .
however , these early advantages can be short - lived and limited by the relatively brief duration of action of currently available local anesth... | background and aims : the primary aim of this study was to evaluate the effect of addition of dexmedetomidine on the duration of analgesia in patients undergoing upper limb surgeries under supraclavicular brachial plexus block.material and methods : sixty patients of american society of anesthesiologists physical statu... |
compounds that stabilize microtubules ( msa ) , which include taxanes ( paclitaxel , docetaxel ) , are effective anticancer drugs .
it is known that the therapeutic effect of these drugs is associated with cell cycle arrest , followed by initiation of apoptotic processes .
however , the exact mechanism that links c... | aim . to study the significance of cyclin - dependent kinases ( cdks ) in paclitaxel - dependent apoptosis in colon and undifferentiated thyroid cancer cells . materials and methods .
experiments were performed on undifferentiated thyroid carcinoma ( ktc-2 ) and colon carcinoma ( aro ) cell lines .
cells were treat... |
hek293 cells were maintained in dulbecco 's
modification of eagle 's medium ( dmem ) supplemented with 10% fetal bovine serum
( sigma ) .
mda - mb-231 and mda - mb-468 breast cancer cells were obtained from the
atcc ( rockville , md ) and grown in dmem / ham 's f-12 medium supplemented with 10%
fetal bovi... | dlc-1 encodes a rho gtpase - activating protein ( rhogap ) and
negative regulator of specific rho family proteins ( rhoa - c and cdc42 ) .
dlc-1
is a multi - domain protein , with the rhogap catalytic domain flanked by an
amino - terminal sterile motif ( sam ) and a carboxyl - terminal start
domain .
t... |
ovarian cancer is responsible for almost half of deaths from cancer of the female genital tract because malignant tumours often spread outside the ovary by the time a definite diagnosis is made .
they tend to affect the axial skeleton and are associated with abdomino - pelvic disease .
median interval time between ... | bony metastases from ovarian cancer are rare , tend to affect the axial skeleton and are associated with abdomino - pelvic disease .
the median time interval between diagnosis of ovarian carcinoma and presentation of bony metastases is 44 months ( 1 ) .
we describe a rare case of high grade left ovarian serous / en... |
it is assumed that it mediates protection by stimulating macrophages for mycobacteria killing [ 13 ] .
the concept is supported by the increased susceptibility of ifn--deficient mice to experimental tb [ 46 ] and severe mycobacterial infections in humans bearing mutations in ifn-/ifn- axis [ 79 ] .
however , severa... | ifn- is a key cytokine in antituberculosis ( tb ) defense .
however , how the levels of its secretion affect m. tuberculosis ( mtb ) infection is not clear .
we have analyzed associations between ifn- responses measured in quantiferon-tb gold in - tube ( qft ) assay , tb disease severity , and mtb infection activit... |
ectopic liver tissue develops at various sites near the liver , such as the gallbladder , intra - abdominal ligaments , omentum , retroperitoneum and thorax [ 1 , 2 , 3 ] .
the incidence of ectopic liver tissue has been reported to be 0.240.47% [ 3 , 4 ] .
ectopic liver is a very rare entity , usually asymptomatic ... | ectopic hepatocellular carcinoma ( hcc ) is a very rare clinical entity that is defined as hcc arising from extrahepatic liver tissue .
this report presents a case of ectopic multiple hcc arising in the abdominal cavity . a 42-year - old otherwise healthy male presented with liver dysfunction at a general health chec... |
four different types of dendritic cells exist in lymph nodes , namely , histiocytic , fibroblastic , interdigitating , and follicular cells .
their main function is the presentation of antigens and the generation and regulation of the germinal center reaction .
follicular dendritic cells participate in the immune s... | interdigitating dendritic cell sarcoma ( idcs ) is an extremely rare neoplasm arising from the antigen - presenting cells of the immune system .
this disease usually involves the lymph nodes , and rarely , extranodal sites may be affected .
the authors report a case of extranodal idcs presenting in the pleura . a 3... |
a rapid and good outcome osseointegration is a fundamental prerequisite for a successful dental implantation and depends on the shape , structure , and composition of the used surface .
the main requirements for a good material are its ability to promote attraction and adhesion of bone precursor cells and their proli... | background : the main requirements for a good material are its ability to promote attraction and adhesion of bone precursor cells and their proliferation and differentiation .
different biocompatible materials are currently employed as scaffold . among these
, titanium is considered a gold standard because of its b... |
anterior crossbite is defined as a malocclusion resulting from the lingual positioning of the maxillary anterior teeth in relationship to the mandibular anterior teeth.1 dental crossbite involves localized tipping of a tooth or teeth and does not involve basal bone.2 patients with anterior dental crossbite will show a ... | anterior crossbite is the term used to describe an abnormal labiolingual relationship between one or more maxillary and mandibular incisor teeth .
different techniques have been used to correct anterior crossbite .
this paper describes the use of bonded resin - composite slopes for the management of anterior crossb... |
ewing s sarcomas is a rare primitive neuroectodermal tumour ( pnet ) which has an annual incidence of 2.9 /million population in usa 1jeffery toretsky et al ( 2008 ) they are very uncommon in african and asian population .
it is commonly associated with reciprocal translocation between chromosome 11 and 12 t ( 11:12 ... | introduction : ewing s sarcomas is a rare primitive neuroectodermal tumour ( pnet ) which has an annual incidence of 2.9 /million population in usa 1jeffery toretsky et al ( 2008 ) they are very uncommon in african and asian population . it is commonly associated with reciprocal translocation between chromosome 11 and ... |
in general we differentiate between the terms benefit basket ( also benefit package ) and benefit catalogues .
the benefit basket refers to the totality of services , activities , and goods covered by publicly funded statutory / mandatory insurance schemes ( social health insurance , shi ) or by national health ... | this article identifies and analyses a framework for health baskets , the taxonomy of benefit catalogues for curative services , and the criteria for the in- or exclusion of benefits in nine eu member states ( denmark , england , france , germany , hungary , italy , the netherlands , poland and spain ) .
focusing o... |
lymphocytes survey antigen by circulating through blood , lymph nodes ( lns ) and lymph and shape specific immune responses in lns . to enter lns
, lymphocytes must undergo extensive interactions with high endothelial cell venules ( hevs ) ( butcher , 1991 , frster et al .
, 2008 , ley et al . , 2007 , muller , 2... | summarylymphocytes circulate through lymph nodes ( ln ) in search for antigen in what is believed to be a continuous process . here
, we show that lymphocyte migration through lymph nodes and lymph occurred in a non - continuous , circadian manner .
lymphocyte homing to lymph nodes peaked at night onset , with cell... |
high rates of infection of target cells with two or more retroviral vectors are often required to achieve a desired biological outcome .
in particular , the production of induced pluripotent stem ( ips ) cells requires a high rate of coinfection in order to obtain a sufficient fraction of cells that express all four ... | amphotropic pseudotyped retroviral vectors have typically been used to infect target cells without prior concentration .
although this can yield high rates of infection , higher rates may be needed where highly efficient coinfection of two or more vectors is needed . in this investigation
we used amphotropic retrov... |
hospital acquired bsis are associated with higher morbidity and mortality , along with increased overall health care costs .
bsis can be primary or secondary bsi , based on the source of origin . primary / intravascular bsi originates from the cardiovascular system itself ; while , some other infectious focus in the ... | purpose : blood stream infection ( bsi)/bacteremia is a potentially life threatening infection and are associated with a high crude mortality .
coagulase negative staphylococcus ( cons ) and staphylococcus aureus are the most commonly isolated gram positive bacteria from blood culture samples .
while s. aureus is a... |
leopold iii , the saint , was the austrian margrave from 1095/1096 until his death in 1136 .
his successful marriage policy led to substantial economical and political wealth of the house of babenberg , which ruled austria between 976 and 1246 . with his second wife agnes of waiblingen , daughter of the salian king h... | the successful marriage policy of margrave leopold iii increased the importance of the house of babenberg in late medieval austria ( 12th century ) .
historical documentation is inconclusive in providing evidence whether or not his eldest son adalbert derived from an earlier relationship or from the marriage with kin... |
nearly 30%65% of adult urban indians are either overweight , obese , or have abdominal obesity .
abdominal obesity plays a major role in the pathogenesis of type 2 diabetes , cardiovascular diseases , and hypertension .
indian data suggest that standard cutoff points to define abdominal obesity , are not appropriat... | objective : to assess the occurrence of diabetes in obese nondiabetic patients over a 3-year follow - up period with a correlative analysis of visceral fat ( vf ) , fasting insulin levels , ( fils ) and insulin resistance ( ir).material and methods : thirty - seven obese and nineteen nonobese nondiabetics of our previo... |
one of the neuropathologic features invariably found in the brains of individuals with alzheimer 's disease ( ad ) is the amyloid - beta ( a ) containing senile plaque ( sp ) .
blood samples have been assessed for changes in a levels driven by the abundant data that a in the brain was the prime candidate for precipi... | the studies employed the cholesterol - fed rabbit model of alzheimer 's disease ( ad ) to investigate the relationship between ad - like neurofibrillary tangle ( nft ) neuropathology and tau protein levels as the main component of nft .
we measured brain and plasma tau levels and semiquantified nft - like neuropathol... |
the actual meaning and the selective advantages induced by this deregulation remain nowadays still a matter of debate despite the pioneering work of warburg about the impact of the alteration of the energetic metabolism in cancer cells . certainly , several reasons have significantly contributed to delay the advancemen... | even though altered metabolism is an old physiological mechanism , only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer .
nevertheless , a very poor number of compounds are under investigation as potential modulators of cell metabolism ... |
the foundation for teaching and learning of family medicine for undergraduates was laid in sri lanka in the year 1983 and a limited clinical exposure was introduced to the curriculum of the faculty of medicine , university of colombo . family medicine was introduced to the undergraduate curriculum of the faculty of med... | background : family medicine occupies a prominent place in the undergraduate curriculum of the faculty of medicine , university of kelaniya , sri lanka . the one month clinical attachment during the fourth year utilizes a variety of teaching methods .
this study evaluates teaching learning methods and learning enviro... |
impairments in physical and cognitive functioning , as well as onset of chronic diseases , are often feared in later life as such changes lead to dependence in tasks of daily living , depression , and hospitalization .
compared to white elders , african american older adults experience a greater number of years expos... | an older adult 's ability to perform physical tasks is predictive of disability onset and is associated with declines in cognition .
risk factors for physical performance declines among african americans , a group with the highest rates of disability , remain understudied .
this study sought to identify demographic... |
since first described in 1970 ( 1 ) , prostate - specific antigen ( psa ) was considered a useful tumor marker for detecting prostate cancer ( pca ) and assessing treatment responses and follow - up among patients with pca gradually .
a psa level of more than 4.0 ng / ml was considered to have predictive value for th... | background : we aimed to value the usefulness of free to total prostate - specific antigen and prostate - specific antigen ( psa ) density for prostate cancer in the patients with psa levels of 4.0 ng / ml or less.methods:a total of 343 subjects with psa levels of 4.0 ng / ml or less were biopsied .
all patients were... |
kidney transplantation is the treatment of choice for selected patients with end - stage renal disease ( esrd ) .
health - related quality of life ( hqol ) has emerged as an important outcome to quantify the success of transplantation in the long term [ 1 , 2 ] . although hqol has been systematically assessed to unif... | little is known on long - term outcomes in kidney transplantation .
this study evaluated changes and predictors of generic and transplantation - specific health - related quality of life ( hqol ) over six years in n = 102 kidney transplant survivors using the short - form health survey-36 and the transplant effects q... |
glucagon - like peptide-1
( glp-1 ) is a key incretin hormone with
diverse physiological functions in both the periphery and central
nervous system ( cns ) that are mediated by the glp-1 receptor ( glp-1r ) ,
a family b g protein - coupled receptor ( gpcr ) .
glp-1r is activated
by four endogenous glp-1 pep... | a duplexed ,
functional multiaddition high throughput screen and
subsequent iterative parallel synthesis effort identified the first
highly selective and cns penetrant glucagon - like peptide-1r ( glp-1r )
positive allosteric modulator ( pam ) .
pam ( s)-9b potentiated low - dose exenatide to augment insulin ... |
renal angiomyolipomas ( raml ) are uncommon benign renal tumours , composed of fat cells , smooth muscle cells and blood vessels . they are associated with a tendency to rupture resulting in sometimes - torrential retroperitoneal hemorrhage as the wunderlich syndrome or as severe potentially exsanguinating hematuria ... | renal angiomyolipomas ( raml ) are uncommon benign renal tumours that are associated with a tendency to rupture resulting in sometimes - torrential retroperitoneal hemorrhage as the wunderlich syndrome or as severe potentially exsanguinating hematuria .
when hemorrhage from raml occurs in pregnancy it presents a uniq... |
diabetic ketoacidosis ( dka ) is an acute metabolic complication that occurs mainly in type 1 diabetes mellitus ( 1 ) .
the risk factors are omission of insulin , infection , trauma and acute pancreatitis ( 2 , 3 ) .
insulin deficiency increase free fatty acid ( ffa ) and amino acids release from adipose tissue and... | we report a case of diabetic ketoacidosis ( dka ) and hypertriglyceridemia ( severely elevated to 15,240 mg / dl ) complicated by acute pancreatitis , which was treated successfully with insulin therapy and conservative management . a 20-yr - old woman with a history of
type 1 diabetes came to the emergency departmen... |
posttraumatic cerebral infarction ( ci ) is a well recognized complication of traumatic brain injury ( tbi ) and is frequently associated with a poor outcome17 ) .
however , its frequency , timing , and risk factors are not well - defined17 ) .
furthermore , few data are available to quantify risk factors related t... | objectiveposttraumatic cerebral infarction ( ci ) is a well - known complication of traumatic brain injury ( tbi ) .
however , the causation and apportionment of trauma in patients with ci after tbi is not easy .
there is a scoring method , so - called trauma apportionment score ( tas ) for ci , consisted with the ... |
medical
interventions directly targeting epigenetic functionalities
are among the most promising novel approaches for treatment of serious
pathological states such as cancer , metabolic and neurological diseases ,
inflammation , and viral infections . the first marketed epigenetic drug ( vorinostat ) provided i... | bromodomains ( brds )
are epigenetic interaction domains currently
recognized as emerging drug targets for development of anticancer
or anti - inflammatory agents . in this study , development of a selective
ligand of the fifth brd of polybromo protein-1 ( pb1(5 ) ) related to
switch / sucrose nonfermenting (... |
cellulose is the most abundant biomass on earth . it is the primary product of photosynthesis in terrestrial environments and the most abundant renewable bioresource produced in the biosphere [ 2 , 3 ] .
this enzyme is produced by several microorganisms , commonly by bacteria and fungi [ 47 ] .
the source of cellul... | cellulase - producing bacteria were isolated from soil and identified as pseudomonas fluorescens , bacillus subtilis , e. coli , and serratia marcescens .
optimization of the fermentation medium for maximum cellulase production was carried out .
the culture conditions like ph , temperature , carbon sources , and ni... |
in this issue of critical care , dr haenggi and co - workers from bern university hospital present a study evaluating bispectral index ( bis ) , state entropy ( se ) and response entropy ( re ) during sedation in 44 patients in the intensive care unit ( icu ) .
the authors used a meticulous protocol with parallel se... | in this issue of critical care , dr haenggi and co - workers present a study evaluating bispectral index ( bis ) , state entropy ( se ) and response entropy in 44 patients sedated in the intensive care unit ( icu ) . as in recent studies attempting to correlate frontal electroencephalogram ( eeg ) measurements with cli... |
most thyroid hormones are bound to their carrier proteins such as thyroxine - binding globulin ( tbg ) , thyroxine - binding prealbumin ( tbpa ) , and albumin ( alb ) .
triiodothyronine ( t3 ) distribution in plasma is as follows : 80% bound to tbg ; 9% bound to tbpa ; 11% bound to alb , and 0.3% available as free t3... | we report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism .
the pleural effusion was transudate .
the concentrations of thyroxine - binding globulin ( tbg ) , thyroxine - binding prealbumi... |
sertoli leydig cell tumors are rare sex - cord stromal tumors of the ovary that can present with a variety of histological elements , which may complicate diagnosis and treatment .
a 40-year - old female presenting with pelvic pain is found to have a large complex right adnexal mass and elevated alpha - fetoprotein ... | backgroundsertoli leydig cell tumors are rare sex - cord stromal tumors of the ovary that can present with a variety of histological elements , which may complicate diagnosis and treatment.casea 40-year - old female presenting with pelvic pain is found to have a large complex right adnexal mass and elevated alpha - fe... |
insulin resistance and hyperinsulinemia are associated with hypertension , impaired glucose tolerance , obesity and dyslipidemia ( 1 - 4 ) .
hyperinsulinemia is characterized by low high density lipoprotein ( hdl)-cholesterol and high low density lipoprotein ( ldl)-cholesterol , which causes coronary arteriosclerosis... | insulin resistance is an important risk factor for coronary artery disease .
however , there has been no data regarding its clinical effect on the outcomes of percutaneous coronary intervention ( pci ) in non - diabetic patients .
we analyzed 98 non - diabetic consecutive patients ( 5911.5 yr , male : female=63:35 ... |
insomnia is defined as the subjective perception of difficulty with sleep initiation , duration , consolidation , or quality , which occurs despite adequate opportunity for sleep , and results in some form of daytime impairment .
chronic insomnia is diagnosed according to the diagnostic and statistical manual of ment... | introduction : insomnia is one of the common but neglected conditions seen in family practice with long term and serious effects on health of a patient .
family physicians have the responsibility of diagnosing and adequately treating this .
this study was done to find the prevalence of chronic insomnia in adult pat... |
nowadays , the incidence of fungal agents causing candidiasis has increased remarkably , especially in patients infected with human immunodeficiency virus ( hiv ) , immunocompromised hosts , intravenous drug abusers , bone marrow and solid organ recipient , those who present underlying valvular heart diseases , implant... | background : as regards multilocus sequence typing ( mlst ) method directly analyze the polymorphism within dna sequences ; we performed the first nationwide study on the genotypic relationships of candida albicans strains obtained from oropharynx and bronchoalveolar lavage ( bal ) samples from immunocompromised patien... |
since its establishment by sir william osler in the late 19 century , enormous strides have been made in the overall structure and regulation of residency training to the point that it is now about the only path toward post - graduate medical specialization in most countries .
today , every country has its own accred... | context:off - service clinical rotations are part of the necessary requirements for many residency training programs .
because these rotations are off - service , little attention is given to their structure and quality of training .
this often leads to suboptimal educational experience for the residents on these ... |
the chinese american population is one of the most rapidly growing minorities in the united states [ 1 , 2 ] . according to the usa bureau of the census ( 2010 ) ,
the number of chinese americans increased 229% from 1.62 to 3.8 million from 1990 to 2010 .
one - third of chinese americans ( 1.25 million ) reside in ... | the montreal cognitive assessment chinese - language los angeles version ( moca - chla ) was developed and administered during an in - home interview to 1,192 participants ( mean age 62.5 years , mean education 11.6 years ) in a population - based chinese american eye study ( ches ) in los angeles .
the moca - chla s... |
white matter hyperintensities ( wmh ) are a common sign of cerebrovascular disease visible on brain imaging in older people ( o'sullivan , 2008 ) .
wmh contribute substantially to loss of independence at older ages through a 3-fold increased risk of stroke and a 2-fold increased risk of dementia ( debette and markus ... | cerebral white matter hyperintensities ( wmh ) reflect accumulating white matter damage with aging and impair cognition . the role of childhood intelligence is rarely considered in associations between cognitive impairment and wmh .
we studied community - dwelling older people all born in 1936 , in whom iq had been a... |
the eye is an optical device that transmits and focuses light onto the neural retina ( fig .
the retina , a 0.2-mm - thick central nervous tissue , is the first station of the visual system .
in addition to acting as a light receiver , the retina carries out considerable image processing through circuits that invol... | humans possess the remarkable ability to perceive color , shape , and motion , and to differentiate between light intensities varied by over nine orders of magnitude .
phototransduction
the process in which absorbed photons are converted into electrical responses is the first stage of visual processing , and occur... |
treatment of metastatic tumours of proximal femur usually used to be either palliative in the form of radiotherapy and chemotherapy or a very radical in form of hemipelvectomy and hip disarticulation .
both forms of treatment were associated with dismal outcomes . now with the technological advancement and refinement... | introduction : bone is the third most common site of metastatic disease .
treatment of metastatic tumours of proximal femur usually used to be either palliative in the form of radiotherapy and chemotherapy or a very radical in form of hemipelvectomy and hip disarticulation .
both forms of treatment were associated ... |
our institutional review board approved our retrospective study with a waiver of the informed consent from each patient .
this was a retrospective study for patients with pulmonary cryptococcal infection who were seen in a single tertiary - referral hospital over the course of a 14-year period ( january 1995 to decem... | objectivewe aimed to review the patterns of lung abnormalities of pulmonary cryptococcosis on ct images , position emission tomography ( pet ) findings of the disease , and the response of lung abnormalities to the therapies in non - aids patients.materials and methodswe evaluated the initial ct ( n = 23 ) and 18f - fl... |
amyotrophic lateral sclerosis ( als ) is a fatal paralytic disorder caused by degeneration of motor neurons in the brain and spinal cord .
one tenth of the total als cases occur in familial forms ( fals ) , while the other is sporadic with no known genetic components ( sals ) .
the clinical phenotypes between fals ... | dominant mutations in a cu , zn - superoxide dismutase ( sod1 ) gene cause a familial form of amyotrophic lateral sclerosis ( als ) . while it remains controversial
how sod1 mutations lead to onset and progression of the disease , many in vitro and in vivo studies have supported a gain - of - toxicity mechanism where... |
untreated vertically acquired hiv infection is associated with high mortality rates with a 50% probability of dying by 2 years of age among african cohorts in the pre
however , as hiv epidemics have matured , survival estimates have been successively revised upward , and a substantial number of perinatally infected c... | background : substantial numbers of children with hiv present to health care services in older childhood and adolescence , previously undiagnosed . these slow - progressors may experience considerable chronic ill health , which is not well characterized .
we investigated the prevalence of chronic morbidity among ch... |
the first patient is a 39-year - old male who complained of posterior neck pain and occipital headache on the right side after a rear - end collision , which occurred one month ago . at the time of the accident
, he suffered from radiating pain in the right arm , but the radiating symptom subsided by the time of his ... | a c2 - 3 zygapophygeal joint is a major source of cervicogenic headache .
radiofrequency ( rf ) neurotomy is preformed widely for zygapophygeal joint pain .
conventional rf denervation technique is generally performed under fluoroscopic control .
recently , ultrasound - guided radiofrequency on zygapophygeal join... |
the ability of a biological organism to sense and react to a complex environment requires the development of an intricate sensory system . the adaptive
immune system uses dna recombination to generate a large array of t - cell and b - cell receptors to sense potentially harmful entities in the environment .
in cont... | the discovery of probabilistic promoter switches in genes that code for class i major histocompatibility complex receptors in mouse and human provides a useful paradigm to explain programmed cell fate decisions .
these switches have preset probabilities of transcribing in either the sense or antisense direction , and... |
urinary incontinence is one of the major urinary symptoms in children and adolescents and can lead to major distress for the affected children and their parents . normal daytime control of bladder function matures between 2 and 3 years of age , whereas nighttime control is normally achieved between 3 and 7 years of age... | purposeurinary incontinence is one of the major urinary symptoms in children and adolescents and can lead to major distress for the affected children and their parents . in accordance with the definitions of the standardization committee of the international children 's continence society , daytime urinary incontinence... |
while the characterization of materials by nmr is hugely important in the physical and biological sciences , it also plays a vital role in medical imaging .
this success is all the more impressive because of the inherently low sensitivity of the method .
we establish here that [ ir(h)2(imes)(py)3]cl undergoes both ... | |
over the past 10 to 15 years , new treatment paradigms in rheumatoid arthritis ( ra ) have been developed , including early diagnosis , intensive ( treat to target ) management using disease modifying antirheumatic drugs ( dmards ) alone or in combination , and the advent of targeted biologic therapies .
these new ... | objective .
the present systematic review of ra registry data was undertaken to analyse the time on treatment of licensed tnf inhibitors in patients with ra in europe .
methods .
english language european registry studies comparing tnf inhibitors were searched using medline , embase , cochrane , and who : ictrp u... |
nanostructured titania particles are very attractive for several applications such as photocatalysis , coating , gas sensing , and photovoltaics [ 1 , 2 ] .
the morphology and crystallinity of the titanium dioxide ( tio2 ) particles greatly influence the efficiencies in these applications [ 35 ] .
the active sites ... | titania nanoparticles are prepared by sol gel chemistry with a poly(ethylene oxide ) methyl ether methacrylate - block - poly(dimethylsiloxane)-block - poly(ethylene oxide ) methyl ether methacrylate triblock copolymer acting as the templating agent .
the sol
gel components hydrochloric acid , titanium tetraisopr... |
tricuspid regurgitation ( tr ) after orthotopic heart transplantation ( oht ) is common , with reported prevalence that varies from 19% to 84% . the prevalence and severity of tr increase with the length of followup . in most cases
tr is mild and asymptomatic , but some cases of moderate or severe tr are related to m... | background . tricuspid valve regurgitation ( tr ) after orthotopic heart transplantation ( oht ) is common . the aims of this study were to determine the prevalence of tr after oht , to examine the correlation between its development and various variables , and to determine its outcomes .
methods .
all 163 oht pat... |
the deletion of the short arm of chromosome 18 is thought to be one of the rare chromosomal aberrations . here
the proband is a five - and - a - half - year - old girl who has had phenotypes manifested mainly by ptosis , broad face , broad neck with low posterior hairline , mental retardation , short stature , and ot... | objectivethe deletion of the short arm of chromosome 18 is thought to be one of the rare chromosomal aberrations . here
, we report a case to review this disease.case reportthe proband is a five - and - a - half - year - old girl who has had phenotypes manifested mainly by ptosis , broad face , broad neck with low po... |
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