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professional cleaning is a basic service occupation worldwide , and cleaning products are used daily in different environments , both indoors and outdoors.1,2 in recent years , a growing number of scientific studies have shown an association of cleaning work with respiratory adverse effects including asthma.35 in addit...
background : a growing number of studies have identified cleaners as a group at risk for adverse health effects of the skin and the respiratory tract . chemical substances present in cleaning products could be responsible for these effects . currently , only limited information is available about irritant and healt...
acute decompensation of chronic heart failure ( hf ) is a life - threatening situation with a short - term mortality of approximately 30% . intravenous positive inotropic agents play an important role in the treatment of acute decompensation in patients with systolic hf . although traditional inotropic agents such ...
backgroundlevosimendan ( ls ) is a novel inodilator that improves cardiac performance , central hemodynamics , and symptoms of patients with decompensated chronic heart failure . the aim of this study was to compare the effects of single and repeated ls infusion on left ventricular performance , biomarkers , and neur...
celiac disease is an inflammatory disorder in which the small intestine is damaged as a result of an excessive autoimmune response to gluten . however , the overall morbidity and mortality is moderately elevated in comparison to the general population . this is caused by the development of a number of associated di...
usually , celiac disease has a benign course , though the overall morbidity and mortality have increased . treatment with a gluten - free diet restores the damaged intestinal mucosa . in rare cases a small bowel adenocarcinoma develops . unfortunately , the clinical presentation is not always recognized and prognos...
in june 2005 the centers for disease control and prevention ( cdc ) and the march of dimes , in collaboration with 35 professional and governmental organizations , convened a 3-day summit to discuss an agenda for preconception care programs , research , and policy . the summit was the result of internal workgroup dis...
the centers for disease control and prevention ( cdc ) and 35 partner organizations have engaged in developing an agenda for preconception health . a summit was held in june 2005 to discuss the current state of knowledge regarding preconception care and convene a select panel to develop recommendations and action ste...
radiotherapy represents a cornerstone of the treatment of breast cancer . in the past , the less advanced technology was the cause of severe damage to surrounding tissues in the breast , lung and chest wall . today the planning of irradiation fields guarantees the near total absence of collateral effects , in particu...
we report a case of fever , dyspnea , respiratory failure and migratory , recurrent and bilateral lung opacities 4 months after radiotherapy and hormone therapy following surgery for breast cancer . computerized tomography ( ct ) scans showed infiltrates outside the radiation fields . bronchoalveolar lavage reveale...
effects of endocrine disrupting chemicals ( edcs ) on human health and wildlife are receiving growing attention for the next generation 's health and have been known to interfere with endocrine systems by mimicking , blocking , and triggering actions of hormones and implicated with toxic effects , for example , disorde...
bisphenol a ( bpa ) and alkylphenols ( aps ) are well - known endocrine disrupting chemicals ( edcs ) which may threat the next generations ' health . we performed biomonitoring of these phenols in colostrums to assess risk of the phenols in breast - fed neonates . study subjects were the lactating mothers who deli...
facial trauma may be considered one of the most significant aggressions found in trauma centres due to the emotional consequences , the possibility of deformation , and the economical impact it causes in the health system . because of little protection and considerable exposure of the facial region , a great ...
abstractobjectivesthis study aimed to identify the occurrence , type and severity of body injuries associated in patients with facial trauma , referred to the hospital so vicente de paulo ( hsvp ) in the city of passo fundo - rs , brazil.material and methodsthe study analyzed medical records of 1385 patients who we...
emphysematous pyelonephritis ( epn ) is a necrotizing infection characterized by the presence of gas within the kidney and perinephric tissue . the condition , usually occurring in diabetic patients , is rare and often life threatening . the enteric gram - negative bacilli such as escherichia coli , enterobacter , ...
emphysematous pyelonephritis , though uncommon , is a severe necrotizing kidney infection common in patients with diabetes . surgical treatment has been advocated as the treatment of choice in most of the patients . we present the clinical course of an elderly lady who presented with emphysematous pyelonephritis an...
drug - induced hepatotoxicity is a major contributor to the high attrition rates of drug candidates during preclinical and clinical drug development . it is also responsible for many postlaunch withdrawals and labeling restrictions for drugs which have successfully gone through the discovery and development process ....
high - throughput imaging - based hepatotoxicity studies capable of analyzing individual cells in situ hold enormous promise for drug safety testing but are frequently limited by a lack of sufficient metabolically competent human cells . this study examined cryopreserved heparg cells , a human liver cell line which d...
whole - genome sequencing offers unprecedented opportunity to reveal the genetic determinants of phenotypical characteristics of species . the availability of an increasing number of genome sequences allows conducting genome - wide scans of selection aimed at detecting the molecular footprints of adaptation ( helicon...
the naked mole - rat ( heterocephalus glaber ) is the only rodent species that naturally lacks fur . genome sequencing of this atypical rodent species recently shed light on a number of its morphological and physiological adaptations . more specifically , its hairless phenotype has been traced back to a single amin...
asd is a group of increasingly recognised lifespan persistent neurodevelopmental disorders of early onset [ 3 , 4 ] characterised by abnormalities in language , social interaction and a range of stereotyped and repetitive behaviours . however , autism ( the paradigmatic asd ) is both highly heritable , and associ...
autism spectrum disorder ( asd ) is associated with both ( i ) post - mortem and neuroimaging evidence of abnormal cortical development , and ( ii ) altered signalling in brain derived neurotrophic factor ( bdnf ) pathways - which regulate neuroproliferative and neuroplastic processes . in healthy controls genotype at ...
peritonitis carcinomatosa indicates the presence of malignant cells in the peritoneal cavity , and is a well known complication of a number of malignant diseases . as a result , so - called malignant ascites develops . malignant ascites is characterized by positive cytology of malignant cells . impaired lymphatic dra...
malignant ascites is frequently found with various solid tumors , and no established treatment options exist , apart from symptomatic paracentesis . catumaxomab , a trifunctional bispecific monoclonal antibody , has two binding specificities directed to epithelial cell adhesion molecule ( epcam ) and the t cell antig...
the progress in new antimicrobial agents to multidrug resistant pathogens for the treatment of various infectious diseases is of increasing interest . therefore different plant extracts of many plants have been used locally against various pathogens , which showed positive results . higher plants and their extracts...
oxalis corniculata is a common medicinal plant widely used against numerous infectious diseases . the agrochemical potential of methanolic extract , n - hexane , chloroform , ethyl acetate , and n - butanol fractions were assessed to measure the antibacterial , antifungal , and insecticidal activities of the plant . ...
acute phase proteins ( apps ) are the proteins present in plasma , which increase or decrease by about 25% during an acute inflammatory response . ceruloplasmin ( cp ) a positive app is increased due to stimulation of macrophages and monocytes at the sites of inflammation by cytokines . pleural fluid ( pf ) accumul...
background : differentiating into transudate or exudate is the first step in the evaluation of effusions . light 's criteria is the standard but a significant number of transudates may not be differentiated based on these criteria . acute phase proteins ( app ) are present in plasma , which increase or decrease by ...
oral mucosa is an active site for the onset of numerous opportunistic infections such as oral candidiasis , epstein barr virus ( ebv ) associated oral hairy leukoplakia , kaposi sarcoma , periodontitis , and other ulcerative lesions in hiv infected patients [ 18 ] . the loss of mucosal immunity in the oral mucosa is ...
human and simian immunodeficiency virus ( hiv and siv ) infections are characterized by manifestation of numerous opportunistic infections and inflammatory conditions in the oral mucosa . the loss of cd4 + t cells that play a critical role in maintaining mucosal immunity likely contributes to this process . here we...
odontogenic tumors comprise of a complex group of lesions of diverse histopathological types and clinical behavior . of all swellings of the oral cavity , 9% are odontogenic tumors and within this group , ameloblastoma accounts for 1% of lesions . who defines it as a locally invasive polymorphic neoplasia that often ...
aim : the ameloblastoma is a benign odontogenic tumor of epithelial origin that exhibits a locally aggressive behavior with a high level of recurrence , being believed theoretically to come from dental lamina remains , the enamel organ in development , epithelial cover of odontogenic cysts or from the cells of the basa...
it is well - known that the molecular modeling of many biological processes requires a rigorous treatment of the long - ranged electrostatic interactions . furthermore , recent years have seen the development of many promising next - generation force fields and fast ab initio methods that endeavor to genera...
the ewald , particle mesh ewald ( pme ) , and fast fourier poisson ( ffp ) methods are developed for systems composed of spherical multipole moment expansions . a unified set of equations is derived that takes advantage of a spherical tensor gradient operator formalism in both real space and reciprocal spac...
chronic obstructive pulmonary disease ( copd ) is characterized by persistent airflow limitation and is most often degenerative in nature.1 for this reason , prevention of disease progression is an important therapeutic target in copd patients . although forced expiratory volume in 1 second ( fev1 ) shows only weak c...
backgroundtiotropium failed to slow the annual rate of forced expiratory volume in 1 second ( fev1 ) decline in chronic obstructive pulmonary disease ( copd ) patients with < 70% predicted fev1 . however , the rate of fev1 decline is known to be faster at early stages , which suggests that the effects of tiotropium m...
idiopathic pulmonary haemosiderosis ( iph ) is a rare cause of diffuse alveolar hemorrhage ( dah ) with unknown etiology . dah is characterized by haemoptysis , dyspnea , alveolar infiltrates on chest x - ray , and various degrees of anemia . in iph , it is classic disease of childhood , but approximately 20% of pa...
idiopathic pulmonary hemosiderosis is characterized by recurrent episodes of alveolar hemorrhage , hemoptysis , and secondary iron deficiency anemia with unknown etiology . it generally emerges in childhood and adolescence periods but rarely found in adulthood . definite diagnosis is established by appearing the he...
measures of eeg during ect , for example , smaller post - seizure fractal dimension have predicted antidepressant response . the earlier study on this subject used bilateral ect . this study aims to examine if this finding holds good even for unilateral ect , using both fractal dimension and spectral power analysis o...
background : measures of eeg during ect , for example , smaller post - seizure fractal dimension have predicted antidepressant response . the earlier study on this subject used bilateral ect . this study aims to examine if this finding holds good even for unilateral ect , using both fractal dimension and spectral pow...
non - melanoma skin cancer ( nmsc ) is a disease affecting mostly adult patients in their second half of life . forehead and temple are commonly affected by the major types of nmsc , i.e. basal cell carcinoma ( bcc ) and squamous cell carcinoma ( scc ) . the treatment of choice in particular for larger tumours is m...
radical surgery of fronto - temporal non - melanoma skin cancer ( nmsc ) sometimes causes palsy of the frontal facialis branch . patients may experience visual impairment due to brow and upper eyelid ptosis . since nmsc predominantly affects elderly people , the corrective surgical procedures have to be adapted to ...
today , diabetes is considered as one of the most common metabolic disease worldwide and an important factor for death and disability in various countries including iran . world health organization predicted from 1997 to 2025 increasing of number of people with type ii diabetes worldwide 143 million to 300 million . ...
background : the prevalence of obesity and associated chronic disease such as diabetes is rapidly increasing in all part of the world . the world health organization has predicted that between 1997 and 2025 the number of diabetic patients will increase from 143 million to about 300 million . in diabetic patients , ox...
following mastectomy , tissue expander reconstruction is one of the most common methods for breast reconstruction . the use of acellular dermal matrices ( adms ) has been popularized in the use of tissue expander reconstruction . this biologic matrix provides support in the lower pole of the breast and helps define...
backgroundacellular dermal matrices present a new alternative to supporting expanders and implants for breast reconstruction in breast cancer patients following mastectomy . however , some studies have suggested that acellular dermal matrix may increase the complication rates in certain clinical settings . dermacel...
mucogingival problems form a definitive diagnosis that includes an array of clinical findings , namely gingival recession ( gr ) , shallow vestibule , inadequate width of attached gingiva ( ag ) and aberrant frenulum . surgical endeavor by goldman for the correction of three specific problems , namely periodontal poc...
shallow vestibule , gingival recession , inadequate width of attached gingiva ( ag ) and aberrant frenum pull are an array of mucogingival problems for which several independent and effective surgical solutions are reported in the literature . this case series reports the effectiveness of the bridge flap technique as...
in this work , we coupled on - line kinetic capillary electrophoresis with mass spectrometry ( kce - ms ) to study conformational dynamics of dna g - quadruplexes in solution . we showed that peaks shift and its widening in kce can be used for measuring rate and equilibrium constants for dna metal affinity interacti...
invited for this months cover is the group of prof . maxim v. berezovski . the cover picture shows the two - dimensional separation of unfolded ( green ) and folded ( red ) forms of g - quadruplex ( gq ) dna . the first dimension is kinetic capillary electrophoresis ( kce ) separation of unfolded and folded dna ...
scaling of the quantified dispositional parameters of xenobiotics from animals to man is of interest from the standpoint of toxicology ( e.g. , poisoning and risk assessment ) . scaling is also important from the standpoint of therapeutics because it represents a strategy for predicting first - use - in - human doses...
in recent years , manganese oxides ( mno2 ) have attracted considerable interests due to their distinctive physical and chemical properties and wide applications in catalysis , ion exchange , molecular adsorption , biosensor , and energy storage [ 1 - 5 ] . specifically , manganese oxides have been extensively evalua...
nanostructured -mno2thin films with different morphologies are grown on the platinum substrates by a facile solution method without any assistance of template or surfactant . microstructural characterization reveals that morphology evolution from dandelion - like spheres to nanoflakes of the as - grown mno2is control...
10% of the population has experienced some kind of dental trauma , of which 0.5 to 16% were cases of avulsion of permanent teeth . once avulsed , the tooth must be replanted into its own socket3 in order to reestablish functional normality . for success of replantation , maintenance of viable periodontal ligament cel...
tooth avulsion is a very common event in children and emergency care procedures are crucial for case prognosis . as anyone at the moment of accident can provide first - aid measures , knowledge of school professionals dealing with children is of paramount importance . an informative campaign about dental trauma was...
routine vl testing is not yet widely available globally , with some countries still not recommending routine vl testing at all in their national guidelines , or recommending it only in the case of suspected treatment failure ( mdecins sans frontires [ msf ] access campaign : http://msfaccess.org/hiv-hcv-diagnostic-prod...
cost and complexity have hindered implementation to date of viral load testing in resource - limited settings . if rapid and timely scale - up is to become a reality , numerous factors will need to be addressed , including health and laboratory system strengthening , pricing , and multiple programmatic and funding ch...
in the era of assisted reproduction , we have potential to achieve pregnancy for women at any age . irrespective of menstrual functioning of the women our ability to make this possible with advent of donor embryo transfer have given us a sense of pride and potential to have near control on reproduction biology , but ...
a 65-year - old postmenopausal pregnant woman was referred with antepartum hemorrhage at 29 weeks of gestation . postadmission diagnosed with chronic hypertension , gestational diabetes mellitus , valvular heart disease , and placenta previa . her pregnancy was terminated by cesarean delivery at 32 weeks as she had...
qat leaves contain more than 40 alkaloids , glycosides , tannis , terpenoids and others . cathine and cathinone are the most important alkaloid constituents of qat that have amphetamine like effect . therefore , people chew qat to get psycho - stimulation effect in the form of euphoria and excitement due to its cat...
the effect of a common habit among yemeni population on the periodontal status was investigated . this cross - sectional study was done on 2500 yemenis with mean age 27.01 years ( 1818 males and 682 females ) . among these 1528 were qat chewers and 972 were non - chewers . detailed questionnaire and pre - designe...
an 83-year - old male patient with ventriculoperitoneal shunt underwent radionuclide shunt study using single - photon emission computed tomography / computed tomography ( spect / ct ) to evaluate the shunt patency . the planar images showed activity at the cranial region and spinal canal but no significant activity ...
hugonnet and colleagues present an interesting article on nurse staffing and ventilator - associated pneumonia ( vap ) . although this study joins a number of other studies on nurse staffing and adverse outcomes of hospitalized patients , i feel compelled to address several important limitations of this study . wha...
a body of knowledge exists to suggest an association between nurse staffing and adverse patient outcomes . hugonnet and colleagues add further evidence by linking nurse staffing to late - onset ventilator - associated pneumonia . discussed are a number of concerns surrounding the analytic component of this study , ...
the helicobacter pylori ( h. pylori ) bacterium is responsible for 5.5% of all infection - associated cancers and is the major cause of gastric cancer in consequence of chronic inflammation . persistent gastric mucosa inflammation results in chronic gastritis and progresses through a multistep process to gastric at...
objective . helicobacter pylori ( hp ) is recognized by tlr4 and tlr2 receptors , which trigger the activation of genes involved in the host immune response . thus , we evaluated the effect of eradication therapy on tlr2 and tlr4 mrna and protein expression in h. pylori - infected chronic gastritis patients ( cg - ...
ce vloaded silica mixed oxide ( ce v ) with a ce : v molar ratio of 1:1 was synthesized by the wet impregnation method.46 , 47 , 48 ce(no3)36 h2o , ( 62 mg for 1 % , 124 mg for 2 % and 250 mg for 4 % ; aldrich99 % ) and voso4xh2o , ( 63 mg for 1 % , 126 mg for 2 % and 252 mg for 4 % ; aldrich97 % ) w...
abstractwe designed a ceria vanadia / silica ( ce v / sio2 ) heterogeneous catalyst and used it for the green and efficient synthesis of 2amino3cyano4hpyran derivatives . the green reaction was a multicomponent onepot condensation of 5,5dimethylcyclohexane1,3dione , aromatic aldehyde , and malononitrile in an ecoco...
severe acute respiratory syndrome ( sars ) emerged only in late 2002 , but the rapid transmission of the disease worldwide within a few months has led to serious public health concerns . the putative agent of this new disease , identified in march 2003 , is a novel and more pathogenic strain of the commonly occurring c...
serum samples were obtained from healthcare workers 5 weeks after exposure to an outbreak of severe acute respiratory syndrome ( sars ) . a sensitive dot blot enzyme - linked immunosorbent assay , complemented by a specific neutralization test , shows that only persons in whom probable sars was diagnosed had specific...
tooth eruption has been described as the movement of a tooth from its normal position within the alveolar process towards its functional position in the oral cavity . this process is accompanied by multiple tissue changes , such as resorption and apposition of the alveolar bone and development of the root and periodo...
primary tooth impaction is a rare finding during the development of primary dentition . several factors contribute to the impaction of a deciduous tooth . this report describes the diagnosis and treatment of a 10-year - old boy who presented an impacted second primary mandibular molar . this tooth , located infer...
an arteriovenous fistula ( avf ) is the abnormal connection between an artery and vein that bypasses the capillary bed . congenital avf of the popliteal artery is very rare , with few case reports in the literature . an 89-year - old lady was transferred to our hospital with progressive pain in her right calf radia...
introductionarteriovenous fistula ( avf ) is the abnormal connection between an artery and vein . congenital avf of the popliteal artery is very rare.presentation of case89 year old lady presented with right acute lower limb ischaemia . she had unilateral chronic venous hypertensive change in the right leg . femo...
vaccination against vaccine - preventable diseases is an essential component of women 's primary and preventive health care . to provide the best care for our patients , obstetrician - gynecologists are increasingly called to be vaccinators . a system is in place in this country to track adverse events following vacc...
background . obstetrician - gynecologists are increasingly called upon to be vaccinators as an essential part of a woman 's primary and preventive health care . despite the established safety of vaccines , vaccine adverse events may occur . a national vaccine adverse event reporting system ( vaers ) is a well - e...
compared to hiv - uninfected individuals living with mycobacterium tuberculosis infection ( mtbi ) , people living with hiv ( plhiv ) possess a 2037-fold higher risk of developing tuberculosis ( tb ) . this disease accounts for approximately 25% of all hiv - related deaths [ 13 ] . the prevailing paradigm explaining ...
introduction . our objective is to understand how hiv infection increases the risk of progression from latent tuberculosis ( tb ) to active disease . we understand now that immunity is a balance of competing immune responses by multiple cell types . since t - lymphocyte production of interferon - gamma ( ifn- ) in ...
congenital or primary hypoparathyroidism presenting with new onset seizures in an adult is an infrequent phenomenon . there is a tendency for solo practitioners in india to feel apprehensive about adult patients presenting with new onset seizures . the immediate response is to give an injectable anti - epileptic dr...
hypoparathyroidism commonly presents with paresthesias , fatigue , anxiety , muscle cramps and infrequently with seizures due to hypocalcaemia . here , we present a case of 27-year - old adult female presenting with new onset convulsions who was subsequently diagnosed to have primary ( congenital ) hypoparathyroidism...
the selection of an optimal treatment modality for patients with n2-positive stage iiia ( n2-iiia ) non - small cell lung cancer ( nsclc ) has been a major controversial issue in thoracic oncology . a multimodality approach rather than a single modality therapy has been preferred , and the current national comprehensiv...
purposethis study was conducted to evaluate the treatment outcomes following definitive bimodality concurrent chemoradiotherapy ( ccrt ) in patients with inoperable n2-positive stage iiia ( n2-iiia ) non - small cell lung cancer ( nsclc).materials and methodsfrom may 1997 to december 2012 , 65 out of 633 patients with ...
orthosiphon stamineus benth ( syn . : o. aristatus ( bl . ) miq . , misai kucing , leaves extracts have been used as traditional medicine and possess benefits such as antidiabetic , ability to increase plasma triglyceride and plasma hdl - cholesterol concentrations , anti - lithiatic and hypouricemic effects [ 4 ,...
orthosiphon stamineus benth has been traditionally used to treat hypertension . the study aimed to investigate the vascular reactivity of water extract ( wos ) and water : methanolic ( 1 : 1 ) extract ( wmos ) of orthosiphon stamineus benth and at1 receptors blocker in the mechanisms of antihypertensive mediated ...
the melany cohort has been conducted at the israel defense forces staff periodic examination center ( spec ) , to which all career service personnel aged older than 25 years are referred every 3 to 5 years for a routine health examination and screening tests , as described previously ( 22,23 ) . at each visit to the sp...
objectiveassociation between white blood cell ( wbc ) count and diabetes risk has been recently suggested . we assessed whether wbc count is an independent risk factor for diabetes incidence among young healthy adults.research design and methodswbc count was measured in 24,897 young ( mean age 30.8 5.36 years ) , no...
transradial angiography ( tra ) and transradial coronary intervention ( tri ) have become popular approaches because of several advantages , such as fewer bleeding complications [ 13 ] . however , use of tra and tri is limited for patients with a narrow radial artery , being associated with the risk of artery spasm , o...
the aim of this study was to evaluate the safety and feasibility of the new 5 fr glidesheath slender ( gss ) . the transradial ( tr ) approach has become popular because of several advantages , such as a reduced rate of vascular access site complications . however , because the radial artery is narrow , a limitatio...
spatial organization , from organisms to molecules , is a defining feature of life . in multicellular organisms , cells serve to concentrate and organize biological activities , facilitating metabolism , growth , and division . in eukaryotic cells , biochemical activities can also be concentrated and regulated thro...
eukaryotic genomes are spatially organized within the nucleus by chromosome folding , interchromosomal contacts , and interaction with nuclear structures . this spatial organization is observed in diverse organisms and both reflects and contributes to gene expression and differentiation . this leads to the notion t...
binocular surgery is the most commonly used approach for surgical treatment of large - angle horizontal strabismus involving three or four horizontal rectus muscles . this procedure is widely used because it avoids significant limitations of ocular movement , which could occur in surgeries of greater magnitude.15 how...
objective : to evaluate the results of monocular surgery under peribulbar anesthesia for large - angle horizontal strabismus.introduction:monocular surgery may preserve some muscles if a repeat operation is required , may help to avoid the exposure of the dominant eye to the inherent risks of a surgical procedure and m...
hypothyroidism denotes deficient production of thyroid hormone by the thyroid gland and can be primary ( abnormality in thyroid gland itself ) or secondary / central ( as a result of hypothalamic or pituitary disease ) . the term subclinical hypothyroidism is used to define that grade of primary hypothyroidism , in w...
background : there is a paucity of data on knowledge , awareness , and practices ( kap ) of patients with hypothyroidism in india.aims and objectives : to study the kap and adherence to treatment of participants with primary hypothyroidism.materials and methods : an observational cross - sectional study was conducted i...
the recently published paper by sanchez - sanchez and colleagues is a very interesting and well documented study showing how challenging it is to prevent fluid creep during early resuscitation after major burn trauma . under- and over - resuscitation have been associated with complications and poor outcome not only...
over - resuscitation is deleterious in many critically ill conditions , including major burns . for more than 15 years , several strategies to reduce fluid administration in burns during the initial resuscitation phase have been proposed , but no single or simple parameter has shown superiority . fluid administrat...
c - reactive protein ( crp ) , the prototypic acute phase reactant , is produced primarily by the liver as part of the body 's mechanism to restrict injury and promote repair after an inflammation evoking injury [ 13 ] . crp is a member of the phylogenetically ancient and evolutionarily conserved pentraxin family of ...
raised blood c - reactive protein ( crp ) level is a predictor of cardiovascular events , but whether blood crp is causal in the disease process is unknown . the latter would best be defined by pharmacological inhibition of the protein in the context of a randomized case - control study . however , no crp specific ...
cancer is a serious life - threatening disease . despite the improvements in cancer medicine that are transforming cancer into a chronic and even curable disease patient - perceived severity can be considered a proxy for beliefs about the objective controllability of disease , and is related to health behavior under ...
backgroundrisk perception and efficacy beliefs affect health behavior . the aim of this study was to measure cancer severity and curability ( as proxy for risk perception and efficacy beliefs , respectively ) and their association with clinical and psychosocial variables.methodsa consecutive sample of cancer patients...
spontaneous basal ganglia hemorrhage ( bgh ) is the most common hemorrhagic stroke , imposing significant socio - economic burden on the victims.18 ) anatomically , the basal ganglia generally refer to a set of subcortical nuclei , such as striatum , composed of the caudate nucleus and putamen , globus pallidus , subst...
objectivethe clinico - radiologic features of the spontaneous basal ganglia hemorrhage ( bgh ) may often differ one from another , according to its regional location . therefore , we attempted to classify the bgh into regional subgroups , and to extrapolate the distinct characteristics of each group of bgh.materials ...
the symmetry of biomolecules originating from gene duplication and consolidated by evolution , while often only approximate , is intimately linked to functionality . for transmembrane proteins ( tmps ) in particular , symmetry is one of the common properties shared in their functional states , and it has been r...
numerous biomolecules and biomolecular complexes , including transmembrane proteins ( tmps ) , are symmetric or at least have approximate symmetries . highly coarse - grained models of such biomolecules , aiming at capturing the essential structural and dynamical properties on resolution levels coarser than...
vascular complications after renal transplantation occur frequently and can lead to the deterioration of renal function , graft loss , and even death . iliac vein stenosis is a rare complication after renal transplantation , with only a few cases reported to date , , . here , we describe a case of iliac vein stenosis...
iliac vein stenosis is a rare vascular complication of renal transplantation that may compromise allograft function if not recognized and corrected in a timely fashion . because chronic venous stenosis may remain undiagnosed for several years , a high index of suspicion should be maintained until diagnosing this rare d...
adolescent idiopathic scoliosis ( ais ) is a complex and progressive condition , which can affect patients quality of life ( qol ) . changing the qol there are a few qol questionnaires dedicated for patients with ais : srs-22 , scoliosis quality of life index ( sqli ) and sf-36 seem to be the most diffused [ 2 , 3 ] ...
purposethe aim of the study was to undertake the process of cultural adaptation of the brace questionnaire ( brq ) into polish.methodsthe brq is an instrument for measuring the quality of life of scoliotic adolescents who are being treated conservatively with wearing a corrective brace . the brq consists of 34 likert...
several novel astroviruses have been recently discovered in humans and in other animals . here , we report results from our surveillance of astroviruses in human and rodent faecal samples in hong kong . classical human astroviruses ( n=9 ) and a human mlb1 astrovirus were detected in human faecal samples ( n=622 ) . ...
the robert wood johnson foundation funded hablamos juntos ( hj ) , a $ 10-million multiyear demonstration to improve access to health care for latinos with limited english proficiency and to explore cost - effective ways for health care organizations to provide language access services . in this manuscript , the auth...
backgroundthe robert wood johnson foundation funded hablamos juntos ( hj ) , a $ 10-million multiyear demonstration to improve access to health care for latinos with limited english proficiency and to explore cost - effective ways for health care organizations to provide language access services.hablamos juntosin this ...
the objective of this report is to document the combination of intussusception and malrotation in an adult and to discuss clinical features and the treatment used in this case . a 25-years - old female patient presented in surgical emergency with complaints of diffuse pain abdomen , associated with vomiting , inabili...
the authors report a case of waugh 's syndrome in an adult . waugh 's syndrome is rare in adults as most of the cases present in paediatric age group . we have discussed treatment options and it is suggested that the possibility of waugh 's syndrome should always be kept in mind when a case of intussusception is be...
chronic obstructive pulmonary disease ( copd ) is predicted and reported as the third cause of death in 2030 by world health organization ( who ) and is receiving gaining attention due to the increase in elderly population , in addition to the pollution worsening all over the world . besides , it is known that ...
[ purpose ] fragmentary studies on characteristics of respiratory muscles are being done to increase respiratory capacity by classifying exercises into voluntary respiratory exercise which relieves symptoms and prevents copd and exercise using breathing exercise equipment . but this study found changes on respira...
all participants signed informed consent forms , and the study adhered to the tenets of the declaration of helsinki . the study initially included 24 eyes of 24 patients who presented to the retina clinic at the hospital , were diagnosed with unilateral exudative amd , and underwent anti - vegf treatment with intravi...
purposeto determine the effects of intravitreal anti - vascular endothelial growth factor ( vegf ) on thickness of the retinal nerve fiber layer ( rnfl ) in patients with age - related macular degeneration.methodstwenty eyes of 20 patients diagnosed with age - related macular degeneration who underwent intravitreal ant...
neuropathic pain is a devastating condition , and our lack of knowledge regarding its pathogenesis has hampered efforts to find an effective treatment . increasing evidence has shown that mitogen - activated protein kinase ( mapk ) plays important roles in the induction and maintenance of chronic pain . the mapk fa...
background : najanalgesin , a toxin isolated from the venom of naja naja atra , has been shown to exert significant analgesic effects in a neuropathic pain model in rats . however , the molecular mechanism underlying this protective effect of najanalgesin is poorly understood . the present study sought to evaluate the ...
tuberculosis ( tb ) remains a major cause of morbidity and mortality in many countries and a significant public health problem worldwide.(1 ) tb kills more adults in india than any other infectious disease . controlling tb in india is a tremendous challenge and the burden is still staggering.(2 ) the revised national...
background : the most effective dots provider will be the one who is accessible , acceptable to the patient , and accountable to the health system.objectives:the objective was to assess the effectiveness of the different types of dots providers functioning under revised national tuberculosis control programme ( rntcp)....
the life - style of women in developing countries is changing due to a shift in age at marriage and child bearing . working mothers show a low inclination toward breast feeding and an increased trend in early weaning . fine - needle aspiration cytology ( fnac ) of palpable breast lesions has become a boon in develo...
background : the incidence of breast carcinoma is increasing in developing countries due to adoption of western life - style . fine - needle aspiration cytology is the initial method to evaluate the palpable breast lesions . the neoadjuvant therapy is helpful in treating high grade rather than low grade breast carc...
twenty - two sites in five european countries ( france , germany , norway , romania , and spain ) participated in this phase 2 , open - label , randomized , controlled 16-week trial . the trial protocol was approved by local institutional review boards , and all subjects gave written informed consent . the study wa...
objectiveinsulin degludec / insulin aspart ( idegasp ) is a soluble coformulation of the novel basal analog insulin degludec ( ideg : 70% ) and insulin aspart ( iasp : 30% ) . we compared the safety and efficacy of idegasp , an alternative formulation ( af ) ( 55% ideg and 45% iasp ) , and insulin glargine ( iglar ) ...
portal vein thrombosis ( pvt ) after liver transplantation ( lt ) is one of serious complications and reportedly ranges from 2% to 13% . a 60-year - old female underwent living - donor lt with the left liver graft for end - stage liver disease related to chronic hepatitis c. after reperfusion , indocyanine green ( ic...
highlightsportal vein thrombosis after liver transplantation is one of serious complications.indocyanine green ( icg)-fluorescence imaging can visualize the impaired perfusion or congestive area on the liver graft surface clearly.icg-fluorescence imaging can visualize regions with impaired hepatic perfusion during live...
geneexpression profiling approaches divided all into several subcategories , in which prognoses and frequencies according to age differ significantly.12 herein , we introduce one of the new all categories , phlike all , which is related to highrisk all . philadelphia chromosome positivity signifies the result of a tr...
acute lymphoblastic leukemia ( all ) occurs with high frequency in childhood and is associated with high mortality in adults . recent technical advances in nextgeneration sequencing have shed light on genetic abnormalities in hematopoietic stem / progenitor cells as the precursor to all pathogenesis . based on these ...
reversible posterior leukoencephalopathy syndrome ( rpls ) is radiologically characterized by symmetrical subcortical areas of vasogenic edema that are preferentially parieto - occipital , and it typically resolves after appropriate treatment . we present a patient with strikingly unilateral rpls that developed 21 da...
backgroundreversible posterior leukoencephalopathy syndrome ( rpls ) is radiologically characterized by symmetrical subcortical areas of vasogenic edema that are preferentially parieto - occipital , and it typically resolves after appropriate treatment.case reportwe present a patient with strikingly unilateral rpls tha...
the science of outcome prediction is particularly useful in the setting of the emergency room the entry point of many to acute care . in this issue of critical care jaimes and coworkers evaluate the usefulness of artificial neural networks ( anns ) in predicting hospital mortality in patients presenting to the emerg...
the past 25 years have witnessed the development of improved tools with which to predict short - term and long - term outcomes after critical illness . the general paradigm for constructing the best known tools has been the logistic regression model . recently , a variety of alternative tools , such as artificial n...
some examples include clostridium difficile , methicillin - resistant staphylococcus aureus ( mrsa ) , extended spectrum beta - lactamase producing gram - negative bacilli and acinetobacter baumanii . there is overwhelming evidence that the use of antibiotics is a driving factor for the emergence of resistance . th...
problems with antibiotic resistant bacteria are increasing in the hospital and particularly in the intensive care unit . methicillin - resistant staphylococcus aureus , acinetobacter baumanii and extended spectrum beta - lactamase producing gram - negative bacilli constitute a therapeutic and infection control challe...
the chromosome 11q13 deletion syndrome , the otodental syndrome or oculo - oto - dental syndrome , is a rare but severe autosomal dominant craniofacial anomaly1 ) . they described that the syndrome is characterized by multiple dental abnormalities that included large , globe - shaped molars , absent or small premolar...
chromosome 11q13 deletion syndrome has been previously reported as either otodental syndrome or oculo - oto - dental syndrome . the otodental syndrome is characterized by dental abnormalities and high - frequency sensorineural hearing loss , and by ocular coloboma in some cases . the underlying genetic defect causi...
primary central nervous system lymphoma ( pcnsl ) is a rare variant of extranodal non - hodgkins lymphoma ( nhl ) . cure is achieved only in a minority of patients using high - dose chemotherapy with or without whole brain irradiation . however , combined chemoradiotherapy often is associated with severe neurotoxic...
b - cell activating factor belonging to the tumor necrosis factor family ( baff ) and a proliferating inducing ligand ( april ) might play an important role in the pathogenesis of systemic b - cell malignancies . however , the baff / april system has not been systematically evaluated in primary central nervous system...
atrial septal defect ( asd ) is a tissue defect which allows blood passing between both atria , and accounts for approximately 5 - 10% of all congenital heart defects.1 ) under clinical situations such as high proportions of left - to - right shunts , right ventricular volume overloads and paradoxical embolisms , the c...
atrial septal defect ( asd ) is the common congenital anomaly which requires surgical interventions . right atrial thrombus formations after primary suture repairs of the asd and evidences of thromboembolic complications are extremely rare . specifically , the cases of thromboembolic complications have high mortality...
a 42-year - old man , who had complained of seizure and headache , was admitted to another hospital , where angiography and ct revealed an avm in the left occipital lobe , with hematoma ( fig . preembolic cerebral angiography revealed a left - sided occipital avm fed by the left posterior parietal artery and branches...
we present a case in which an arterial rupture occurring during embolization of an arteriovenous malformation of the left occipital lobe with a flow - directed microcatheter , was successfully sealed with a small amount of glue . we navigated a 1.8-fr magic catheter through the posterior cerebral artery , and during ...
numerous syndromes of a suspected infectious origin remain of unknown microbial aetiology even after investigation by a thorough microbial diagnostic assessment that includes the use of broad - range bacterial pcr targeting the 16s rrna encoding gene on normally sterile samples . however , this technique fails to det...
since routine eubacterial 16s rrna pcr does not amplify members of the chlamydiales order , we tested all samples received in our laboratory during a 10 months period using a pan - chlamydiales real - time pcr . 3 of 107 samples ( 2.8% ) revealed to be positive , suggesting a role of some chlamydiales in the pathogen...
heart failure is one of the most common causes of hospitalization and death , with an increasing trend in the number of patients living with heart failure.1 it has been acknowledged that several comorbid conditions and biomarkers are associated with disease progression and outcome in heart failure.2 indeed , because th...
abstractaimsaltered thyroid hormone metabolism characterized by a low triiodothyronine ( t3 ) , socalled lowt3 syndrome , is a common finding in patients with severe systemic diseases . additionally , subclinical thyroid dysfunction , defined as abnormal thyroid stimulating hormone ( tsh ) and normal thyroxine ( t4 )...
non - small cell lung cancer ( nsclc ) is the most common diagnosed cancer and the leading cause of cancer death worldwide ( 1 , 2 ) . in china , new nsclc cases are approximately 569 , 000 annually ( 3 ) . platinum - based chemotherapy remains the first - line treatment for advanced nsclc , especially in patients wi...
objective this phase i study was to evaluate safety , maximum tolerated dose , pharmacokinetics and preliminary antitumor activity of chidamide , a novel subtype - selective histone deacetylase ( hdac ) inhibitor , in combination with paclitaxel and carboplatin in patients with advanced non - small cell lung cancer ( n...
substances that may act as estrogens show a broad chemical structural diversity . to thoroughly address the question of possible adverse estrogenic effects , reliable methods are needed to detect and identify the chemicals of these diverse structural classes . we compared three assays -- in vitro estrogen receptor co...
ventricular septal defect ( vsd ) complicating acute myocardial infarction ( ami ) is reported in 0.2 % the patients in this thrombolytic era . in the first week emergent surgical closure of post infarction vsd with or without appropriate revascularization irrespective of the clinical status had been the standard tre...
percutaneus device closure appears to be safe and effective in patients treated for a residual shunt after initial surgical closure , as well as after two to three weeks of index myocardial infarction . the index case presented with a ventricular septal defect on second of acute myocardial infarction thrombolysed wit...
there are two conventional wisdoms about weather and electoral participation ( see knack 1994 ; gomez et al . 2007 ; and references therein ) . one is that inclement weather on election day reduces voter turnout , whereas pleasant weather encourages people to vote in greater numbers . the common belief is that poor...
inclement weather on election day is widely seen to benefit certain political parties at the expense of others . empirical evidence for this weather - vote share hypothesis is sparse however . we examine the effects of rainfall and temperature on share of the votes of eight political parties that participated in 13...
a 32-year - old male from nepal presented to the oculoplasty clinic with complaints of redness and swelling of both the upper eyelids followed by progressive drooping for the last 5 years . there was no history of diurnal variation , double vision , trauma or any previous surgery . the patient also gave history of ...
pachydermoperiostosis ( pdp ) is a multisystem disorder of mesenchymal origin . it is a form of hypertrophic osteoarthropathy . the typical clinical features include pachydermia , cutis verticus gyrata , digital clubbing , and periostosis . patients present with mechanical ptosis resulting from markedly thickened...
amyotrophic lateral sclerosis ( als ) is a fatal neurodegenerative disease that causes progressive muscular atrophy and death within 35 years after its onset . most patients have the so - called sporadic als , with unknown etiology ; and approximately 10% of the patients have the familial form of the disease , when m...
amyotrophic lateral sclerosis ( als ) is a fatal neurodegenerative disease that causes progressive muscular atrophy and death within 35 years after its onset . despite the significant advances in knowledge of als pathology , no effective treatment is available . therefore , it is imperative to search for new altern...
emmons - type olefinations . incorporating -substitution in a stereodefined ,-unsaturated ester has been a significant limitation to date for this method . there are several valuable natural product cores that can be elaborated using the described -arylated phosphonoacetates , especially the cinnamic acid cor...
a versatile and general catalytic strategy has been developed for the -arylation of phosphonoacetates utilizing parallel microscale experimentation . these -substituted phosphonoacetates are widely useful , notably as substrates in the horner wadsworth emmons - type olefinations . however , the current...
they are present in the eye in high concentrations . the retina and lens in general and the macular region in the center of the retina in particular there is increasing evidence that lutein and zeaxanthin may play an important role in protecting against several eye diseases , such as age - related macular degeneratio...
the effects of lutein and zeaxanthin on lipopolysaccharide- ( lps- ) induced secretion of il-8 by uveal melanocytes ( um ) were tested in cultured human um . mtt assay revealed that lps ( 0.011 g / ml ) and lutein and zeaxanthin ( 110 m ) did not influence the cell viability of cultured um . lps caused a dose - d...
it is well - established that obesity is associated with a substantial burden of illness and health care costs . obesity is associated with an increased risk of hypertension , diabetes mellitus , hyperlipidemia , coronary artery disease and many other noncontiguous diseases . the economic costs associated with the ...
background : some local governments have implemented strategies to increase physical activity as a way to control obesity in children , but in iranian students few studies have evaluated the effects of such interventions on overweight and obese children . the aim of this study was to evaluate the effects of a short -...
the migration of peripheral circulating monocytes into tissues is considered an important process in the immune response , including inflammatory reactions . during this process , monocytes migrate from the circulation , across the endothelium and the basement membrane , and into the affected tissue . when monocytes ...
monocyte migration into tissues , an important event in inflammation , requires an intricate interplay between determinants on cell surfaces and extracellular matrix ( ecm ) . galectin-3 is able to modulate cell - ecm interactions and is an important mediator of inflammation . in this study , we sought to investiga...
oral cavity cancer involves the lesions occurred in the tongue , lip mucosa and floor of the mouth . one of the standard methods for control of oral cavity tumors is the external radiation therapy in which the linac or cobalt 60 source ( 60co ) is used for irradiation . beside the positive effect of radiation in oral...
the cancer of oral cavity is related to lesions of mucous membrane of tongue and gum that can be treated with radiation therapy . a lateral photon field can be used to treat this kind of tumor , which has a side - effect on normal tissue in the opposite side of the oral cavity . in this study the dosimetric effect ...
we present an atypical presentation of this disease with rare pathological finding in the setting of ulcerative colitis ( uc ) . this patient came to our institution as a referral for management of worsening colitis and difficulty passing stool . initial colonoscopic and radiographic studies revealed a large mass i...
basaloid cancers of the lower gastrointestinal tract are rare . the lack of mucosal involvement of this type of tumor is uncharacteristic and , to our knowledge , has not been described . in addition , the cylindroma - like appearance of this cancer has only a few examples in the literature . a 51-year - old male...
a number of surgical options are available for treating medial unicompartmental osteoarthritis ( oa ) of the knee , such as high tibial osteotomy ( hto ) , unicompartmental knee arthroplasty , and total knee arthroplasty . however , the activities of patients after arthroplasty may be limited and revision surgery is ...
purposethe purpose of this study was to compare the mechanical stability of three types of plate systems for opening wedge high tibial osteotomy.materials and methodsforty - eight fresh frozen porcine tibia specimens were assigned to three different fixation device groups : aescular group ( 16 specimens ) was fixed wit...
transplantation of mobilized peripheral blood stem cells ( pbscs ) is used to facilitate hematologic recovery after high - dose chemotherapy.1,2 although several methods for mobilization of pbscs have been described,35 leukapheresis is a commonly used collection procedure . pbsc yield is enhanced if collection is per...
backgroundbiosimilar granulocyte colony - stimulating factor ( g - csf ) has recently been introduced into clinical practice . g - csfs are used to mobilize cd34 + cells and accelerate engraftment after transplantation . however , in asia , particularly in japan , data for peripheral blood stem cell ( pbsc ) mobiliza...
surfactant proteins ( sps ) , originally known as human lung surfactants , are essential to proper respiratory structure and function . they are unique in composition , consisting of about 90% lipids , mostly phospholipids , and 810% surfactant - associated proteins . sps line the alveolar surface , and reduce surf...
surfactant proteins ( sps ) , originally known as human lung surfactants , are essential to respiratory structure and function . there are 4 subtypes , sp - a , sp - b , sp - c and sp - d , with sp - a and sp - d having immunological functions , and sp - b and sp - c having physicochemical properties that reduce the ...
sh is defined as a serum tsh concentration below the reference range , with normal free t4 ( ft4 ) and free t3 ( ft3 ) levels . it can be divided into two groups ; patients with a mildly reduced tsh ( 0.10.4 mu / liter ) can be classified as having grade i sh , whereas those with a serum tsh of less than 0.1 mu / lit...
context : several studies have reported an association between low serum tsh , or subclinical hyperthyroidism ( sh ) , and dementia , but little emphasis has been placed on this field because not all studies have demonstrated the same association . we performed a detailed systematic review to assess the evidence avai...
the most currently used adhesive system classification is based on the number of steps necessary for clinical application and their interaction with dental hard tissues . total etch adhesive systems , which remove the smear layer with phosphoric acid and combine the functions of primer and adhesive in one bottle , ha...
objective : this in vitro study investigated the effect of a desensitizer on the degree of conversion of two bonding resins using fourier transform infrared ( ftir ) spectroscopy.materials and methods : an etch - and - rise bonding resin and a self - etching adhesive resin were selected for the study . vivasens ( ivo...
atopic dermatitis ( ad ) is a common multifactorial disease characterized by an itchy , recurrent , flexural and symmetrical eczematous eruption . its frequency increases during childhood but it usually resolves by the age of 30 years . acetylation is a metabolic pathway in a number of drugs , which exhibits a gene...
background : few studies have been done on the relation between acetylator status and allergic diseases.aim:to determine any possible association between acetylating phenotype in pediatric patients with atopic dermatitis ( ad ) and the disease prognosis.patients and methods : thirty - six pediatric patients and forty t...
since abumi et al . first reported cervical pedicle screw fixation and its application in over 300 cases , this technique has received increasing attention . compared to lateral mass screw fixation and anterior cervical fixation , cervical pedicle screw fixation has higher pullout force resistance [ 35 ] . cervical...
backgroundthe aim of this study was to compare the accuracy of cervical pedicle screw placement between a three - dimensional guidance system and manual manipulation.material/methodseighteen adult cadavers were randomized into group a ( n=9 ) and group b ( n=9 ) . ninety pedicle screws were placed into the c3-c7 unde...
ruptured rudimentary horn is a life threatening obstetrical emergency encountered frequently in the emergency department where the diagnosis is either missed or delayed . unicornuate uterus results from abnormal development and fusion of the mullerian ducts usually associated with various degrees of rudimentary horn wh...
rudimentary horn is a developmental anomaly of the uterus . pregnancy in a non - communicating rudimentary horn is very difficult to diagnose before it ruptures . a case of undiagnosed rudimentary horn pregnancy at 22 weeks presented to nizwa regional referral hospital in shock with features of acute abdomen . chan...
bochdalek hernia is a congenital posterior lateral diaphragmatic defect , which allows abdominal viscera to herniate into the thorax . intrathoracic ectopic kidney accounts for 5% of all renal ectopias and its association with congenital diaphragmatic hernia has been reported to have an incidence of only 0.25% . we...
bochdalek hernia is a congenital diaphragmatic defect that allows abdominal viscera to herniate into the thorax . intrathoracic kidney is a very rare finding representing less than 5% of all renal ectopias . a 20 year old female presented with complaints of dry cough since 15 days and intermittent fever of 4 days d...
at present , while the trend of cigarette smoking is either stable or decreasing , the trend of other forms of tobacco use , most notably the waterpipe is increasing . waterpipe has a history of as long as four centuries and originates from india and ancient persia . during the past decade , waterpipe smoking ( als...
background : because of the increasing usage of waterpipe globally , we need to know more about the different factors related to waterpipe and cigarette smoking . therefore , the present study aims at gaining more insight on waterpipe and cigarette smoking based on perceived parental reaction and appeal and repellent...
rett syndrome ( rtt ) , an x - linked neurodevelopment disorder affecting almost exclusively females , is associated with a single monogenic mutation ( methyl - cpg binding protein 2 , mecp2 ) in up to 95% of cases , more rarely by mutations in cyclin - dependent kinase - like 5 ( cdkl5 ) , and forkhead box protein g1 ...
rett syndrome ( rtt ) , a neurodevelopmental disorder affecting exclusively ( 99% ) female infants , is associated with loss - of - function mutations in the gene encoding methyl - cpg binding protein 2 ( mecp2 ) and , more rarely , cyclin - dependent kinase - like 5 ( cdkl5 ) and forkhead box protein g1 ( foxg1 ) . in...
leishmaniasis , also known as kala - azar ( literally meaning black fever or black disease ) is a zoonosis caused by protozoan of the genus leishmania , which is transmitted by bite of insect vector phlebotomus sandfly . still it is a rare infection in postrenal transplant setting with atypical presentation leading t...
visceral leishmaniasis ( kala - azar ) is a disease caused by protozoa of genus leishmania . it is currently regarded as the second most dreaded parasitic disease , next to malaria . there have been very few case reports of visceral leishmaniasis among the renal transplant recipients . we present a renal allograf...
the drosophila slowpoke channel ( dslo ) is a large conductance voltage - gated , calcium - dependent potassium channel ( atkinson et al . , 1991 ; dslo has many tissue - specific splice variants with different properties ( becker et al . , 1995 ; atkinson et al . , 1998 ) , and plays important roles in neuronal ex...
the drosophila slowpoke calcium - dependent potassium channel ( dslo ) binding protein slob was discovered by a yeast two - hybrid screen using the carboxy - terminal tail region of dslo as bait . slob binds to and modulates the dslo channel . we have found that there are several slob proteins , resulting from mult...