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it can be caused by posture induced common peroneal nerve ( cpn ) palsy , a kind of peripheral nerve entrapment syndrome common in asian culture as a result of sitting preferences .
peroneal nerve innervates muscle groups related to ankle motion while walking , and patients have difficulties in normal gait if injured... | objectiveposture induced common peroneal nerve ( cpn ) palsy is usually produced during the prolonged squatting or habitual leg crossing while seated , especially in asian culture and is manifested by the onset of foot drop .
because of its similarity to discogenic foot drop , patients may be diagnosed with a lumbar ... |
similarly to its human ortholog , docrl associates with the membrane of several class of endosomes .
docrl insures that ptdins(4,5)p2 pools are principally restricted at the plasma membrane by dephosphorylating this phosphoinositide on endomembranes . when docrl is knocked - down by rnai
, drosophila cells in cultu... | inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions .
ptdins(4,5)p2 , one of the most abundant phosphoinositides , is restricted at the plasma membrane where it regulates numerous functions including cell division .
we have recently established that the drosophil... |
heart failure ( hf ) is a major health problem for many developed world populations and has a relatively poor prognosis . within the us population ,
the incidence approaches 1% , with a lifetime risk of 1 in 5 for both men and women at the age of 40 years . in 2005
, there was an estimated near 1.1 million admissio... | context . heart failure ( hf ) is a common condition causing much morbidity and mortality despite major advances in pharmacological and device therapies .
preclinical data suggest a cardioprotective role of angiotensin-(1 - 7 ) in animal models of hf . objective .
perform a systematic review on the effects of angio... |
in 1993 , skibbens and salmon published a study using high - resolution time - lapse video microscopy that provided crucial insight into how chromosomes move in living cells ( skibbens et al . , 1993 ) .
their four key observations were that ( 1 ) the rates of chromosome movement are the same at different positions o... | the contributions of key molecules predicted to align chromosomes at the center of the mitotic spindle have been recently examined .
new results dictate that models for how chromosomes align during the early stages of mitosis must be revised to integrate properties of microtubule - based motor proteins as well as mic... |
prostaglandins ( pgs ) are an important class of lipid hormones that have been extensively investigated and implicated in regulating reproduction , immunity , and development in a wide array of organisms .
pgs are ideally suited for comprehensive systems biology analyses because they comprise a series of lipids deriv... | caenorhabditis elegans is emerging as a powerful animal model to study the biology of lipids1 - 9 .
prostaglandins are an important class of eicosanoids , which are lipid signals derived from polyunsaturated fatty acids ( pufas)10 - 14 .
these signalling molecules are difficult to study because of their low abundan... |
substantial evidence indicates that smoking bans reduce the adverse effects of exposure to tobacco smoke . as a result of this evidence ,
furthermore , partial smoking bans in indoor public places and workplaces are becoming a common occurrence .
however , the issue of implementing complete smoking bans in all indo... | purposethe objective of this study was to measure secondhand smoke ( shs ) exposure in personal computer ( pc ) rooms with the purpose of determining the strength of scientific evidence supporting the legislative ban on smoking in pc rooms located in the republic of korea.materials and methodsfrom june to september 201... |
extraskeletal myxoid chondrosarcoma ( emc ) is a rare malignancy with distinctive morphologic , histologic , and immunohistochemical features .
it occurs preferentially in men at a 2:1 ratio , with 50% of all cases occurring during the 5th or 6th decade of life .
this cancer has historically been described as slow ... | extraskeletal myxoid chondrosarcoma ( emc ) is a soft tissue malignancy characterized by specific chromosomal abnormalities involving the tec gene .
this disease has historically been considered largely indolent both histologically and clinically .
rarer subsets of emc exist that demonstrate aggressive histopatholo... |
before starting the experiment , one needs to prepare the internal solution for the patch clamp recordings , as well as the artificial cerebrospinal fluid ( acsf ) for the hippocampus preparation . you will furthermore need a dissection kit consisting of surgical scissor and fine iris scissor , two spatulas and forceps... | astrocytes form together with neurons tripartite synapses , where they integrate and modulate neuronal activity . indeed , astrocytes sense neuronal inputs through activation of their ion channels and neurotransmitter receptors , and process information in part through activity - dependent release of gliotransmitters .... |
we conducted a prospective case control study ( case : control ratio 1:3.5 ) of patients admitted to ttsh during june 21november 21 , 2015 ( epidemiologic weeks 2546 ) . using a standardized , interviewer - administered questionnaire , we collected information on food exposure history , in particular consumption of ra... | an outbreak of invasive group b streptococcus ( gbs ) disease occurred in singapore in mid-2015 .
we conducted a case control study of 22 adults with invasive gbs infections during june 21november 21 , 2015 .
consumption of raw fish was strongly associated with invasive sequence type 283 infections , but not with ... |
an estimated $ 58 billion
in medical costs are associated with chronic
wound complications afflicting over 18 million diabetics in the united
states ; 24% of diabetics can expect to
undergo limb amputation within their lifetime as the result of a chronic ,
nonhealing wound .
the social and economic
burden... | wound bioburden in
the form of colonizing biofilms is a major contributor
to nonhealing wounds .
staphylococcus aureus is a
gram - positive , facultative anaerobe commonly found in chronic wounds ;
however , much remains unknown about the basic physiology of this opportunistic
pathogen , especially with reg... |
this paper outlines the rationale for choosing outcome measures to assess the effectiveness of virtual reality for children with burns undergoing dressing changes at the red cross children s hospital ( rcch ) in cape town , south africa .
we have previously reported a profile of burns inpatients at the rcch.1 over 60... | backgroundvirtual reality is consistently reported as effective in reducing pain and anxiety in children during burns dressing changes in recent western studies .
pain scales are a commonly reported outcome measure .
virtual reality is persuasive for all children in distress during medical procedures , because it i... |
osteoporosis is a very common disease in japan that is associated with significant morbidity , mortality , and economic / social burdens [ 17 ] . indeed
, recent estimates from japan suggest that 3.4%12.4% of men and 16.3%26.5% of women ( mean ( standard deviation ) age : 69.9 ( 11.2 ) years ) have lumbar , femoral n... | adherence and persistence with osteoporosis treatments are essential for reducing fracture risk .
once - daily teriparatide is available in japan for treating osteoporosis in patients with a high risk of fracture .
the study objective was to describe real - world adherence and persistence with once - daily teripara... |
a 67-year - old obese man was referred for further investigation following an episode of sudden - onset left - sided loin pain that had lasted for 6 h and then resolved spontaneously .
he had type 2 diabetes mellitus , but no other relevant past medical history . physical examination revealed a large left - sided irr... | obstructive uropathy secondary to uretero - inguinal hernia is a rare phenomenon .
two types have been described - the rarer extraperitoneal type is frequently associated with other renal anomalies .
pre - operative diagnosis is essential in order to reduce the risk of ureteric injury intra - operatively .
we des... |
capture management ( cm ) is a programmable feature that allows automatic adjustment of pacing amplitudes in response to changing pacing thresholds .
it monitors whether pacing pulses capture the myocardium and , optionally , adjusts their amplitude to changing patient conditions . in cm operation ,
the device prep... | aimsthe secura icd and consulta crt - d are the first defibrillators to have automatic right atrial ( ra ) , right ventricular ( rv ) , and left ventricular ( lv ) capture management ( cm ) .
complete cm was evaluated in an implantable cardioverter defibrillator ( icd ) population.methods and resultstwo prospective c... |
bipolar disorder ( bd ) is a major affective disorder marked by recurrent / cyclical episodes of mania / hypomania and depression as described in the diagnostic and statistical manual of mental disorders , 5th edition.1 the subtypes of bd include bipolar disorder i ( bd - i ) and bipolar disorder ii ( bd - ii ) .
pat... | introductiondata specific to late - life bipolar disorder ( bd ) are limited .
current research is sparse and present guidelines are not adapted to this group of patients.objectiveswe present a literature review on clinical characteristics , comorbidities , and cognitive impairment in patients with late - life bd .
... |
coenzyme q10 ( coq10 ) , also known as ubiquinone or ubiquinone-10 , occurs widely in animals , plants , and the cells of microorganisms .
it plays a crucial role in generation of cellular energy and in free radical scavenging in the human body .
accordingly , it has been used in therapeutic applications for severa... | coenzyme q10 ( coq10 , ubiquinone ) , a potent antioxidative dietary supplement , was produced by submerged fermentation using agrobacterium tumefaciens instead of chemical synthesis or solvent extraction .
agrobacterium tumefaciens 1.2554 was subjected to mutagenesis using a series of treatments including high hydro... |
periarticular calcification , characterized by pathological or radiographical evidence that it calcificates around articulations , may be located in cartilage , synovium , capsule , tendons , bursa , ligaments , soft tissue , and vessels ( 1 ) .
acute calcific periarthritis ( acp ) is an acute periarticular inflammat... | this report describes a 22-yr - old professional golfer with acute calcific periarthritis of the proximal interphalangeal joint of the 4th finger .
we considered that the major cause for this condition may be the repeated minor traumas to the affected site . also , since this condition is self - limiting , a correct ... |
the integrin gp iib / iiia receptor is the final common pathway for platelet aggregation .
abciximab is an anti - integrin fab fragment of a human - mouse chimeric monoclonal antibody with high affinity and a slow rate of dissociation from the gp iib / iiia platelet receptor1 ) .
intravenous glycoprotein ( gp ) iib... | glycoprotein ( gp ) iib / iiia inhibitors , such as abciximab , are used as adjunctive therapy for percutaneous coronary intervention ( pci ) in high - risk non - st - elevation myocardial infarction ( nstemi ) and in st - elevation myocardial infarction ( stemi ) , although their effects when used for stemi are less c... |
injury , disease , and congenital malformation have always been part of the human life .
so if damaged body parts can be restored with natural tissue , one would have no complaints of such undesired events .
tissue engineering or tissue regeneration is a multidisciplinary field with the perspective to replace tissu... | within the precedent decade , a new field of tissue engineering or tissue regeneration emerge that offers an innovative and exhilarating substitute for maxillofacial reconstruction .
it offers a new option to supplement existing treatment regimens for reconstruction / regeneration of the oral and craniofacial com... |
using dc targeting for vaccination requires in the first instance an overview of the different mouse and human dc subsets and their functions in immunity .
although extensive work has been undertaken in characterizing mouse dc subsets , their human counterparts have remained difficult to define due to their paucity i... | dendritic cell ( dc ) targeting is a novel strategy to enhance vaccination efficacy .
this approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of dcs . here
we review the complexity of the dc subsets and the antigen presentation path... |
chronic kidney disease ( ckd ) , which affects individuals worldwide , is now recognized as a major public health problem .
interstitial fibrosis is regarded as the main pathway for ckd progression , which culminates in end - stage renal failure . despite the great effort invested in identifying therapies for ckd
i... | background : chronic kidney disease ( ckd ) has become a public health problem .
new interventions to slow or prevent disease progression are urgently needed . in this
setting , cell therapies associated with regenerative effects are attracting increasing interest .
we evaluated the effect of embryonic stem cells... |
anemia is a major health problem globally , which can cause a vicious impediment on quality of life , mortality , morbidity , and socioeconomic progress of a country .
it affects more the developing than the developed countries.1 anemia is the most common hematologic abnormality among hiv - infected individuals ; thi... | backgroundanemia is a major public health problem in hiv patients around the world .
it has a negative effect on the quality of life of hiv patients and progression of the hiv disease . in the sub - saharan african setting , including ethiopia where both hiv infection and under - nutrition are expected to be high , t... |
buckley s commentary on our study of rock climber s withdrawal experiences raises a number of important questions surrounding the concept of extreme or adventure sports addiction . drawing on the few available investigations of this topic
, we respond to buckley s questions here , though emphasize the need for furthe... | |
the poor survival statistics of epithelial ovarian cancer ( eoc ) are mentioned by way of introduction in almost all review literature pertaining to the disease . unfortunately , in the past forty years there have been only small improvements in overall ovarian cancer survival rates .
specific challenges to the tre... | epithelial ovarian cancer ( eoc ) is the most lethal gynecologic cancer and also one of the most poorly understood .
other health issues that are affecting women with increasing frequency are obesity and diabetes , which are associated with dysglycemia and increased blood glucose . the warburg effect describes the ab... |
the risk of developing coronary heart disease ( chd ) depends on several factors that are related to both lifestyle and genetics .
recent genome - wide association studies have identified around 50 chromosomal loci that are robustly associated with chd .
mega et al studied whether the developing of genetic risk sco... | genetic variants have been associated with the risk of coronary heart disease ( chd ) .
mega et al studied the association of a genetic risk score based on 27 genetic variants with incidents of recurrent chd , adjusting for traditional risk factors using data from a community based study and 4 randomized controlled t... |
autoimmune pancreatitis ( aip ) is a rare disease that closely mimics pancreatic cancer ( pc ) in its presentation .
it is very important for clinicians to distinguish one from the other because their treatment and prognosis are vastly different .
typical radiological imaging findings , in particular observation of... | introduction and backgroundautoimmune pancreatitis ( aip ) is a rare disease that closely mimics pancreatic cancer ( pc ) in its presentation .
it is very important for clinicians to distinguish one from the other because their treatment and prognosis are vastly different .
typical radiological imaging findings , i... |
chronic subdural hematoma ( sdh ) is known to have a good prognosis after simple burr hole drainage , and thus , most neurosurgeons do not consider chronic sdh seriously .
contralateral or bilateral development of an acute subdural hematoma immediately after removal of chronic sdh have been previously reported to be ... | burr hole drainage has been widely used to treat chronic subdural hematomas ( sdh ) , and most of them are easily treated by simple trephination and drainage . however , various complications , such as , hematoma recurrence , infection , seizure , cerebral edema , tension pneumocephalus and failure of the brain to expa... |
periapical granuloma ( pg ) and periapical cyst ( pc ) are the most common inflammatory jaw lesions .
they are usually initiated by the mixed microflora of infected root canals , which includes gram - positive and gram - negative bacteria .
the invasion of bacteria or bacterial toxins into the periapical region inv... | toll - like receptors ( tlr ) are essential for the innate immune response against invading pathogens and have been described in immunocompetent cells of areas affected by periapical disease . besides initiating the inflammatory response
, they also directly regulate epithelial cell proliferation and survival in a va... |
protein sequences are of utmost importance for studying the function and evolution of genes and genomes . evolutionary processes of mutation and selection have shaped the protein sequence space and became manifest in the protein sequences as well as their pair - wise and group - wise similarities .
therefore , a rich... | the prediction of protein function as well as the reconstruction of evolutionary genesis employing sequence comparison at large is still the most powerful tool in sequence analysis . due to the exponential growth of the number of known protein sequences and the subsequent quadratic growth of the similarity matrix ,
t... |
the national institutes of health considers pacific islanders to be an underserved and disadvantaged ethnic subgroup .
chamorros , micronesians , tongans , and samoans are the four main groups within the pacific islander populations . the chamorro community is made up of people indigenous to the mariana islands , wit... | this study examined the role of sociodemographic characteristics , health insurance , cancer knowledge , perceived health risk , and having a recent physicians visit on breast and cervical cancer screening utilization among a randomly selected group of chamorro women ( n = 250 ) residing in san diego , california .
... |
for a lot of patients who are seeking facial rejuvenation , injectable filling agents show great promise to improve somebody s appearance without surgery . according to the american society of aesthetic plastic surgery
, it has been recently reported that more than 5 million procedures have been performed using cosme... | injectable filling agents offer the promise of a better appearance without surgery and , among them , hyaluronic acid is the most commonly used .
although complications are rare , it is necessary to know the possible side effects and complications in order to be prepared for their management .
that is why many rese... |
a 35 year old woman presented with lower abdominal pain , vaginal bleeding , and dyspareunia . during gynecological diagnostic laparoscopy ,
a pelvic floor hernia was suspected , and a general surgical evaluation was sought . at a subsequent laparoscopy , the diagnosis of a left direct inguinal and a right obturat... | objective : review of international literature reveals eight reported cases of laparoscopic obturator hernia repair .
non - specific signs and symptoms make the diagnosis of an obturator hernia difficult .
laparoscopic intervention provides a minimally invasive method to simultaneously diagnose and repair these her... |
answer : this is langer 's axillary arch , or axillopectoral muscle , an anatomical variation encountered in the axilla , usually occult in standard imaging assessment , and represents a muscular bundle that originates from the latissimus dorsi , traverses the axilla in front of the axillary neurovascular bundle and fi... | key clinical messagelanger 's axillary arch is usually asymptomatic and difficult to detect preoperatively .
when present , it is important for surgeons operating in the axillary region , to identify correctly the relevant anatomy . simple surgical division is curative and necessary in order to achieve exposure of th... |
carbamazepine , a first line antiepileptic belonging to the iminostilbene group , contributes to 46.9% of antiepileptic drug overdose in the united kingdom .
we report the occurrence of recurrent and protracted hypoglycemia in the setting of carbamazepine overdose .
a 20-year - old pregnant woman at 26-weeks of ges... | carbamazepine overdose usually presents with neurological manifestations such as ataxia , seizures and altered sensorium or cardiac manifestations that include tachycardia , hypotension and ventricular extra - systoles .
we report a patient with carbamazepine overdose who manifested recurrent hypoglycemia on the thir... |
the myocardial sympathetic nervous system is activated in patients with chronic heart failure ( chf ) and has been shown to be associated with increased mortality .
cardiac sympathetic innervation can be scintigraphically visualized by i - metaiodobenzylguanidine ( i - mibg ) , a radiolabelled analog of noradrenalin ... | the aim of this study was to explore if estimates of renal function could
explain variability of 123i - metaiodobenzylguanidine ( 123i - mibg ) assessed myocardial sympathetic activity .
furthermore estimates of renal function were compared to 123i - mibg as predictors of cardiac death in chronic heart failure ( ch... |
the occurence in the kidney and other locations is uncommon [ 3 , 4 ] .
most of the reported cases are histologically benign ; there are fewer cases of malignant fibrous tumors .
malignant solitary fibrous tumor is a rare neoplasm , which includes therapeutic and prognostic specialties .
an 84-year - old woman wa... | we report a case of a large malignant solitary fibrous kidney tumor .
a complete surgical resection of the primary tumor and peritoneal disease was carried out , and a histological examination confirmed the initial diagnosis .
we describe and discuss the characteristics of this rare kidney neoplasm . |
certain endoscopic lesions will require to be marked in order to be found at a later stage , either during surgery or at posterior endoscopies .
some techniques are available for that purpose , such as radiological tests , the placement of clips , intraoperative endoscopy , or tattooing .
the latter is widely used ... | endoscopic tattooing is a simple and effective technique for marking small lesions , so they can be localized during surgery or in later endoscopies .
various agents can be used such as india ink or a solution of purified carbon particles .
the number of complications from tattooing is relatively small , but not ra... |
pain is a protective mechanism which has adaptive value , and the inability to experience pain has been linked to early mortality from accidental injuries or damage to joints.1,2 however , pain in the postoperative setting is an unwanted side effect of surgery directed to improve morbidity or mortality .
the potentia... | many attempts have been made to increase the duration of local anesthetic action .
one avenue of investigation has focused on encapsulating local anesthetics within carrier molecules to increase their residence time at the site of action .
this article aims to review the literature surrounding the recently approved... |
the jages cohort was established in 2010 to investigate factors associated with subjective and objective health among noninstitutionalized individuals 65 years or older .
we used the 2013 wave of jages , where self - reported questionnaires were mailed to 195,290 community - dwelling individuals 65 years or older .
... | abstractthe aim of this study was to evaluate the association of laughter with subjective health independent of socioeconomic status and social participation among older people in japan .
we used the data of 26,368 individuals ( men , 12,174 ; women , 14,194 ) 65 years or older who participated in the japan gerontolo... |
a variety of test methods are
discussed for the diagnosis of proximal tooth
surfaces .
adjuncts such as bitewing radiography and fiber - optic transillumination provide an
improvement to unaided vision .
unaided visual diagnosis had detected fewer than
50% of caries lesions on occlusal surfaces and ... | objective .
the purpose of this study was to evaluate the efficiency of operating microscope compared with unaided visual examination , conventional and digital intraoral radiography for proximal caries detection .
materialsand methods .
the study was based on 48 extracted human posterior permanent teeth .
the ... |
the status of muscle can be
characterized by using measures of its strength and mass1 . of various methods for measuring muscle mass ,
the european working
group on sarcopenia in older people ( ewgsop ) has recommended dual - energy x - ray
absorptiometry ( dxa ) , bioimpedance analysis ( bia ) , and anthropome... | [ purpose ] the purpose of this study was to describe the relationship between three
practical measures used to characterize muscle mass : mid - arm circumference , maximum calf
circumference , and muscle mass index determined using bioimpedance analysis .
[ subjects and
methods ] thirty - eight ambulatory wome... |
squamous cell carcinoma ( scc ) is by far the most important and common malignant mucosal neoplasm to affect the head and neck region .
occasionally , variants of scc may be encountered , which includes verrucous , exophytic or papillary , spindle cell ( sarcomatoid ) , basaloid and adenosquamous types that make up i... | of the many neoplasms known , squamous cell carcinoma ( scc ) is the most common to affect the oral cavity .
spindle cell carcinoma ( spcc ) is considered a rare high malignant variant of scc occurring predominantly in the upper aerodigestive tract .
soft - tissue spindle cell neoplasms are quite uncommon in the or... |
we sequenced the genome of a clostridium tetani strain that caused chronic tibial osteitis without any clinical sign of tetanus in a 26-year - old man previously vaccinated against this disease .
the genome contained a plasmid that harboured the tetx - tetr tetanospasmin operon , and was highly similar to that of a t... | |
non - small cell lung cancer ( nsclc ) is the major cause of cancer - related deaths worldwide.1 platinum - based combination chemotherapy , which has represented the only therapeutic option for patients with advanced nsclc until a few years ago , has yielded a limited outcome improvement with a median overall survival... | despite the improvement in clinical outcomes derived by the introduction of epidermal growth factor receptor ( egfr ) tyrosine kinase inhibitors ( egfr - tkis ) in the treatment of patients with advanced non - small cell lung cancer ( nsclc ) whose tumours harbour egfr - activating mutations , prognosis remains unfavou... |
community structure is influenced by many factors , including genetics , diet , and xenobiotic and antibiotic use ( 4 , 5 , 9 , 15 ) .
the gut microbiome , in particular , plays an important role in metabolism , immune development , and endocrine and neurological signaling ( 10 , 16 ) .
dysbiotic gut communities ha... | the role of the human microbiome is the subject of continued investigation resulting in increased understanding .
however , current microbiome research has only scratched the surface of the variety of healthy microbiomes .
public participation in science through crowdsourcing and crowdfunding microbiome research pr... |
without effective tobacco control measures , it is estimated that by the year 2030 , the annual global death toll will reach 8 million . with current smoking patterns , approximately 500 million people alive today will eventually be killed by tobacco use . currently , there are an estimated 1.3 billion smokers in the w... | background : health systems play key roles in identifying tobacco users and providing evidence - based care to help them quit .
this treatment includes different methods such as simple medical consultation , medication , and telephone counseling . to assess different quit smoking methods selected by patients in tobac... |
atra receptors ( rars ) , and and 9-cis retinoic acid receptors , and ( rxrs ) are encoded by three different genes and are members of the nuclear receptor superfamily .
they function as ligand - inducible transcription factors in the form of rar / rxr heterodimers .
rar is activated by atra and binding of th... | backgroundretinoic acid receptors ( rars ) are ligand - regulated transcription factors controlling cellular proliferation and differentiation .
receptor - interacting proteins such as corepressors and coactivators play a crucial role in specifying the overall transcriptional activity of the receptor in response to l... |
fluoride release ability of glass ionomer cements is well documented.[15 ] anti - caries property is established by increasing enamel resistance to demineralization and enhancing remineralization of the early carious lesion .
the majority of fluoride released from glass ionomers occur within first day after the resto... | background : as glass ionomers have the ability to reload fluoride from outside sources , the aim was to compare the recharge pattern of six glass ionomer cements after exposure to fluoride.materials and methods : fuji vii , fuji ix , riva pink , riva bleach , ketac fil and fuji ix extra were investigated .
the fluor... |
therapeutic applications that engage the mirror system , including action observation
training ( aot ) , motor imagery , and imitation , have been suggested to help improve objective
programming during stroke rehabilitation1 .
aot includes understanding the movement , imitation learning , motor learning , and
c... | [ purpose ] the purpose of this study was to investigate the effects of action observation
training ( aot ) on cerebral hemodynamic changes including cerebral blood flow velocity
( cbfv ) and cerebral blood flow volume ( cbfvol ) in healthy subjects .
[ subjects ] fifteen
healthy subjects participated in this s... |
the intestinal crypt has become the archetypal model for quantitative understanding of adult stem cell dynamics and regulation .
intestinal crypts are finger - like invaginations of the intestinal mucosa lined by a monolayer of epithelial cells . genetic lineage - tracing experiments in mice have shown that stem cell... | summaryhuman intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage - tracing methods are impractical in humans . here
, we have circumvented this problem by quantitatively using somatic mtdna mutations to trace clonal lineages . by analyzing clonal imprints on the walls of col... |
rheumatoid arthritis ( ra ) is an inflammatory polyarthritis with a variable course and prognosis .
the prevalence is approximately 1% and affects females more commonly than males ( 3:1 ) .
upwards of 80% of patients report foot problems during the course of the disease . acquired pes planovalgus ( ppv ) with assoc... | highlights we use ultrasound to guide fine wires into tibialis posterior and record emg signal .
we simultaneously recorded emg and multi - segment foot kinematics .
we examine reliability over time in flat footed rheumatoid arthritis patients . between - day reliability of discrete emg variables
is questionable... |
biomarker expression data are usually characterized by a small number of sample vectors of high dimension , which makes it very difficult to be treated with many kinds of single classifiers . up to now , a possible approach to reduce the dimensionality consists in applying straightforward statistical feature selection ... | in this study , we present a constructive algorithm for training cooperative support vector machine ensembles ( csvmes ) .
csvme combines ensemble architecture design with cooperative training for individual svms in ensembles .
unlike most previous studies on training ensembles , csvme puts emphasis on both accurac... |
microglia are the resident innate immune cells of the central nervous system ( cns ) and play an important role in immune surveillance and in the pathogenesis and progression of a number of cns disorders .
microglia are constantly mobile , spending time scanning the extracellular space of the cns . in response to b... | the p2x7 purinergic receptor is a ligand - gated cation channel expressed on leukocytes including microglia .
this study aimed to determine if p2x7 activation induces the uptake of organic cations , reactive oxygen species ( ros ) formation , and death in the murine microglial eoc13 cell line . using the murine macro... |
autoimmune diseases arise from an overactive immune response of the body against tissues normally present in the body .
organ - specific autoimmune disease can develop through a combination of hereditary and environmental factors that regulate adaptive immune responses to self antigens ( mills , 2011 ) .
several st... | the etiopathogenesis of many autoimmune disorders has not been identified .
the aim of this paper is to focus on the involvement of bacterial exposure , as an environmental factor , in the pathogenesis of autoimmune pancreatitis ( aip ) , which is broadly categorized as autoimmune disorders involving pancreatic lesio... |
little data exist on the management of intravenous drug use ( ivdu ) when treating severe infectious diseases ( i d ) , which necessitate parenteral antimicrobial therapy in rural communities .
rural communities lack specialists in infectious diseases , addiction , or ethics to guide quality initiatives in managing i... | we report a case of an intravenous drug user ( ivdu ) patient who had 4 episodes of endocarditis within a 2-year time period in rural georgia .
the institutional cost was approximately $ 380,000 .
the lack of an established transitional care plan for ivdus to outpatient care is a common phenomenon at institutions .... |
intracellular signalling cascades are the primary routes of communication between the plasma membrane and regulatory targets in various intracellular compartments .
sequential activation of kinases is a widely conserved mechanism of signal transduction in many cellular processes .
protein kinases are ubiquitous enz... | this paper focuses on the role that mitogen - activated protein kinases ( mapks ) play in drug - induced kidney injury .
the mapks , of which there are four major classes ( erk , p38 , jnk , and erk5/bmk ) , are signalling cascades which have been found to be broadly conserved across a wide variety of organisms .
m... |
the cox maze procedure is the most effective procedure for eliminating atrial fibrillation ( af ) and restoring a normal sinus rhythm , and it has evolved from a cut - and - saw technique to ablation using alternative energy sources such as cryothermia and radiofrequency [ 1 - 3 ] . as the operative techniques continue... | backgroundthe aim of this study is to evaluate the clinical and rhythm outcomes of atrial fibrillation ( af ) ablation through a port access approach compared with sternotomy in patients with af associated with mitral valve diseases.materials and methodsfrom february 2006 through december 2009 , 135 patients underwent ... |
intraorally , the tongue is the most common location . here , a case of a schwannoma of the floor of the mouth in a 28-year - old male
a 28-year - old male patient presented with a complaint of enlarging swelling of 1 month duration in the right anterior floor of the mouth which was otherwise asymtomatic .
on intra... | schwannoma is an intraoral rare , benign neoplasm arising from and consisting solely of schwann cells .
its etiology is unknown .
it presents as a solitary , slow growing , smooth surfaced , generally asymptomatic firm mass .
schwannomas commonly occur between 30 and 50 years .
it is relatively uncommon , altho... |
esophageal ph monitoring was first used by tuttle and grossman in 1958 ( 1 ) .
miller first reported in 1964 the use of an indwelling ph electrode positioned above the lower esophageal sphincter ( les ) to continuously monitor the intraesophageal ph ( 2 ) .
this technique overcame many of the weak points of the oth... | ambulatory 24-hr esophageal ph monitoring is considered the gold standard for diagnosing gastroesophageal reflux disease .
the aim of this study was to establish normal values for gastroesophageal acid exposure in healthy koreans .
fifty healthy volunteers ( 24 males and 26 females ; mean age , 45 yr ) without refl... |
human herpes virus 6 ( hhv-6 ) and human herpes virus 7 ( hhv-7 ) during childhood are really widespread ( 1 , 2 ) , and the same as other herpesviruses , they are latent infections throughout life .
salivary glands act as major sites harbouring persistent hhv-6 infection when hhv-6 is frequently isolated from the sa... | background : the previous studies showed that herpes human virus-6 ( hhv-6 ) and hhv-7 exist in salivary glands .
one of the important areas in oral and maxillofacial pathology field is tumors of the salivary glands . in this study , to declare the major sites of persistent infection with hhv-6 and hhv-7 , the existe... |
dieter gallwitz was the first to discover a yeast - encoded member of the rab family in the 1980s , when dna sequencing was just beginning to be widely adopted and required significant effort .
it was related to ras but could not complement the loss of the yeast ras1 and ras2 genes and thus likely played a different ... | several of the most important discoveries in the field of membrane traffic have come from studies of rab gtpases by marino zerial and peter novick and their colleagues .
zerial was the first to discover that rab gtpases represent identity markers for different membrane - bound compartments , and each rab organizes a ... |
pediatric health care providers use weight to assess normal growth and development and guide nearly all therapeutic and medical interventions that their patients require . as such , significant attention has been paid to weight estimation in settings where the use of a scale is impractical or unavailable . in fact , ne... | objective .
significant attention has been paid to weight estimation in settings where scales are impractical or unavailable ; however , no studies have evaluated the performance of published weight estimation methods in children with down syndrome .
this study was designed to evaluate the predictive performance of... |
during the shock state , understanding the mechanisms of acidosis , its hemodynamic and inflammatory consequences as well as the best therapeutic approach remain an ongoing debate . in the previous issue ,
schotola and colleagues provide , for the first time , new and en - lightening data on the consequence of acidos... | acidosis is one of the major consequences of hemodynamic instability in shock state patients directly associated with multiple organ failure evolution and death .
most studies on the hemodynamic consequences of acidosis have been experimental , nonhuman studies with severe acidosis , and thus far from the most common... |
the identification and characterization of circulating tumor cells ( ctcs ) in the blood of cancer patients can help to diagnose cancer more accurately .
epithelial cell adhesion molecule ( epcam)-based platforms are usually used to capture and identify ctcs [ 13 ] .
ctcs can be successfully characterized by fluore... | the identification of circulating tumor cells ( ctcs ) is clinically important for diagnosing cancer .
we have previously developed a size - based filtration platform followed by epithelial cell adhesion molecule immunofluorescence staining for detecting ctcs .
to characterize ctcs independently of cell surface pro... |
the venous system contains 70% of the cerebral blood volume and is of importance for normal cerebral circulation . although cerebral venous thrombosis ( cvt ) only accounts for approximately 1% of all stroke cases
in addition , cvt is usually noted in young individuals , including children . of all cvt cases ,
howe... | background : cerebral venous thrombosis ( cvt ) may lead to serious neurological disorders ; however , little is known about the risk factors for recurrent cvt .
our aim was to determine the association between elevated fibrinogen and decreased high - density lipoprotein cholesterol ( hdl - c ) levels with recurrent ... |
mesenchymal stem cells ( mscs ) are a subset of adult progenitor cells isolated from hematogenous bone marrow and tissues derived from mesoderm ( dominici et al . , 2006 ) .
experimental studies provided evidence about the effect of bone marrow mesenchymal stem cells ( bmmscs ) on epidermal regeneration ( mcfarlin et... | recent studies provided evidence that mesenchymal stem cells ( mscs ) have regenerative potential in cutaneous repair and profound immunomodulatory properties making them a candidate for therapy of neuroimmunologic diseases .
neuromyelitis optica ( nmo ) is an autoimmune , demyelinating central nervous system disorde... |
inflammatory cells and their reactive oxygen metabolites can cause mutagenic effects in lung cells .
the purpose of this study was to investigate the ability of activated neutrophils to modulate dna binding of benzo[a]pyrene ( b[a]p ) , a known carcinogen , in lung target cells .
equivalent numbers of rat lung epit... | |
they are most numerous in the distal appendages where they play a role in heat exchange .
the majority of glomus tumors ( gts ) , which are mesenchymal in origin , are therefore found in the hands and feet .
the incidence of gastric gts is 100 lower than gastrointestinal stromal tumors ( gists ) . in the largest st... | two recent cases of glomus tumors ( gts ) of the gastrointestinal tract presented with symptoms of gi bleeding .
gts , typically benign lesions of mesenchymal origin , are rarely seen in the gi tract , and most commonly involve the distal appendages .
this case series discusses the tumor biology , presentation , im... |
spondylolisthesis is an unstable lumbar disease demonstrated in approximately 6% of the general population and occurs most often at l4-l5 and l5-s1 levels10,13,14 ) .
anatomy research indicates that isthmic spondylolisthesis usually occurs within the scope of 2 to 9 mm beneath the pedicles , resulting in the defects ... | objectiveto compare the slip reduction rate and clinical outcomes between unilateral conventional transforaminal lumbar interbody fusion ( conventional tlif ) and unilateral minimal invasive tlif ( minimal tlif ) with pedicle screw fixation for treatment of one level low - grade symptomatic isthmic spondylolisthesis.me... |
patients may file a claim if their medical treatment results in an injury or an unexpected side effect . in particular , this kind of risk for medical professional liability claims is a daily consideration for anesthesia providers .
the collection and analysis of data relating to anesthesia - related injuries are thu... | using the korean society of anesthesiologists database of anesthesia - related medical disputes ( july 2009-june 2014 ) , causative mechanisms and injury patterns were analyzed . in total , 105 cases were analyzed .
most patients were aged < 60 yr ( 82.9% ) and were classified as american society of anesthesiologists... |
the raw reads and gene expression data have been deposited in the national center for biotechnology information ( accession no .
the transcription factor slzfp2 negatively regulates aba synthesis during tomato fruit development and ripening , and further protein - dna binding assays identified the ( a / t)(g / c)tt m... | the transcription factor slzfp2 ( solanum lycopersicum zinc finger protein 2 ) regulates aba biosynthesis during fruit development .
to reveal the regulatory network of this transcription factor , we conducted a high - throughput rna - seq to identify differentially expressed genes in 2 dpa ( days post anthesis ) fr... |
it is regarded as an unusual healing pattern of appendicitis in contrast to the conventional pattern .
this type of tissue reaction can involve any organ but the most common sites are kidney and gallbladder .
most of the patients present with a picture of acute or subacute abdominal pain and occasionally with a mas... | xanthogranulomatous reaction can occur in any organ but the most common sites are kidney and gallbladder .
xanthogranulomatous appendicitis ( xa ) is a rare clinical entity .
there are a few case reports of xa diagnosed on histopathology but none on cytology . here
we report a case of a 47-year - old lady who pre... |
the benefits of exercise in the prevention of chronic diseases including overweight and obesity are well documented .
regular physical activity reduces blood pressure , creates a more favorable lipid profile , and reduces risk for stroke , coronary heart disease , hypertension , and colon cancer [ 1 , 2 ] .
regular... | nine female runners and ten walkers completed a 60 min moderate - intensity ( 70% vo2max ) run or walk , or 60 min rest in counterbalanced order .
plasma concentrations of the orexogenic peptide ghrelin , anorexogenic peptides peptide yy ( pyy ) , glucagon - like peptide-1 ( glp-1 ) , and appetite ratings were meas... |
it is a spontaneous rupture of the esophagus caused by impaired coordination of the act of vomiting and attempts to stop it .
the classic symptoms of bs , described in 1952 and known as mackler 's triad , are observed in less than half of the affected patients ; they include : severe and profuse vomiting , acute sha... | esophageal perforation is the fastest progressing and the most life - threatening disruption of gastrointestinal tract continuity .
it must be regarded as an emergency condition that requires early diagnosis as well as very aggressive and rapid implementation of treatment in order to avoid serious complications and d... |
legg - calve - perthes ( lcp ) is the avascular necrosis or idiopathic osteonecrosis of the epiphysis of the femur head1 ) .
the main factor that plays a role in the etiology is the decreased blood flow to the epiphysis of the femur head .
it is more frequently observed among male children between the ages of two a... | legg - calve - perthes ( lcp ) disease is characterized by idiopathic avascular osteonecrosis of the epiphysis of the femur head .
the main factor that plays a role in the etiology of the disease is decreased blood flow to the epiphysis .
many predisposing factors have been suggested in the etiology of lcp disease ... |
interferons are well established agents for standard therapy in several malignancies , hepatitis c , idiopathic pulmonary fibrosis , and multiple sclerosis.1,2 despite this , adverse autoimmune effects associated with their use have been reported , including minimal change disease in the kidney,25 collapsing focal segm... | interferon - beta is widely used for the treatment of relapsing multiple sclerosis .
the drug is usually well tolerated , but autoimmune adverse effects , including kidney disease , have been reported .
only a few cases of hemolytic uremic syndrome - thrombotic microangiopathy associated interferon - alpha have bee... |
the most common way to estimate rates of speciation is to use data from the fossil record .
paleontological studies estimate how many new species formed over a given time interval ( the per lineage speciation rate ; e.g. , stanley 1979 ; van valen 1985 ; jablonski 1986 ; hulbert 1993 ; sepkoski 1993 ) .
many paleon... | understanding the rate at which new species form is a key question in studying the evolution of life on earth . here
we review our current understanding of speciation rates , focusing on studies based on the fossil record , phylogenies , and mathematical models .
we find that speciation rates estimated from these d... |
diabetes type 1 is mainly results from auto - immune beta cell destruction , while viral infections and chemical agents seem to be the triggers of the disease .
the well - documented effect of insulin is to mediate carbohydrates , proteins and lipids storage .
therefore diabetes is considered as a defect of lipids ... | background : diabetes is an important disease .
this disease is a metabolic disorder characterized by hyperglycemia resulting from perturbation in insulin secretion , insulin action or both .
honey bee venom contains a wide range of polypeptide agents .
the principle components of bee venom are mellitin and phosp... |
a pathology text describes choriocarcinoma ( cc ) as an epithelial malignancy of trophoblastic cells that lacks villous organization , with sites of origin being gestational as well as nongestational tissues .
the former includes placental tissue ( whether intra or extrauterine ) whereas the latter comprises sites su... | choriocarcinoma is a human chorionic gonadotrophin ( hcg)-secreting tumor that comprises vascular channels .
it has a tendency for widespread metastasis , common sites for which include the lung , vagina , brain , liver , bone , intestine , and kidney .
we describe a 30-year - old female who presented with hepatiti... |
male accessory gland infection ( magi ) represents a potential cause of male infertility [ 1 , 2 ] , with a different prevalence in the previous published studies .
magi may affect sperm parameters through three possible mechanisms : ( a ) secretory dysfunction of the accessory glands ( epididymis , prostate , and se... | aim of the present study was to evaluate the different ultrasound characterization of fertile symptomatic patients with magi ( male accessory gland infection ) according to different serum concentrations of total t ( tt ) .
we analyzed the ultrasound and hormonal data of 200 patients aged between 24.0 and 67.0 years ... |
conjugated organic structures have attracted significant recent attention due to their potential applications in single - molecule transistors and organic photovoltaics . in the quest for smaller and more efficient electronics , organic semiconductors
serve as a promising alternative to their silicon counterparts bec... | the optoelectronic and excitonic properties in a series of linear acenes ( naphthalene up to heptacene ) are investigated using range - separated methods within time - dependent density functional theory ( tddft ) . in these rather simple systems , it is well - known that tddft methods using conventional hybrid functio... |
cavernous hemangiomas ( ch ) are well - defined lesions composed of closely packed sinusoidal vascular channels with structurally incomplete vessel walls and no intervening neuronal parenchyma . although cavernous malformations are thought to arise sporadically in many individuals , a substantial number of patients hav... | cavernous hemangioma ( ch ) is a sporadic vascular malformation occurring either as an autosomal dominant condition or as a well - known complication of radiation exposure .
medulloblastoma is a primitive neuroectodermal tumor common in children and currently treated with surgical resection , chemotherapy , and radio... |
in the history of treating night blindness , the ancient egyptian , the babylonians , the greeks , and many other cultures after them , used animal liver as treatment , like what we did in rak . in the egyptian papyrus ebers ( 1500 b.c . ) the recommended cure was : roasted ox liver , pressed , applied ( topical to th... | the aim of this article is to briefly review the history of night blindness and its treatment from ancient times until the present .
the old egyptians , the babylonians , the greeks and the arabs used animal liver for treatment and successfully cured the disease . the author had the opportunity to observe the applica... |
elastic fibers are important for elasticity and extensibility of lung tissue . in the developing lung ,
elastic fibers appear in greatest numbers during the process or period of alveolarization .
a variety of mesenchymal cells in lung appear responsible for elastin synthesis .
elastin is a novel protein both from... | |
the increased life expectancy of brazilians , due to scientific and technical advances has
contributed to the changing epidemiological profile . in this sense , the model of health care
focused on infectious diseases has been gradually replaced by a model directed at chronic
diseases .
stroke is classified as c... | [ purpose ] the study analyzed the electroencephalographic ( eeg ) data of the central
cortical areas , during execution of the motor gestures of feeding , activation of the
system of mirror neurons , and imagery between a right hemiparetic volunteer ( rhv ) and a
healthy volunteer ( hv ) .
[ subjects and metho... |
excessive gestational weight gain ( gwg ) , defined as that above the 2009 institute of medicine ( iom ) recommendations,1 is associated with a greater likelihood of having a large for gestational age neonate2 with increased adiposity and insulin resistance.3 similarly , excess gwg is also implicated in adverse materna... | backgroundexcessive gestational weight gain ( gwg ) increases risk of large for gestational age neonates and subsequent tracking of excess weight throughout the life course for both mother and child .
although the physiological mechanisms underlying these associations are incomplete , the insulin - like growth factor... |
aloe vera is a common ingredient in cosmetics , skin care products , and increasingly , beverages and food products .
recent consumer interest in aloe beverages may stem from the association of aloe juice with a variety of both anecdotal and experimental research - supported health benefits including the prevention o... | aloe vera , a common ingredient in cosmetics , is increasingly being consumed as a beverage supplement .
although consumer interest in aloe likely stems from its association with several health benefits , a concern has also been raised by a national toxicology program report that a nondecolorized whole leaf aloe vera... |
overweight and obesity are a global concern in both developed and developing countries and in school age children , the prevalence continues to remain high .
australian childhood overweight and obesity rates have been shown to be 25.3% for boys and girls aged 517 years , comprised of 17.7% overweight and 7.6% obese .... | childhood overweight and obesity are a growing concern globally , and environments , including the home and school , can contribute to this epidemic .
this paper assesses the reliability of two questionnaires ( parent and teacher ) used in the evaluation of a community - based childhood obesity prevention interventio... |
although copper is a trace mineral and accounts for only 0.01% of total body weight , it plays an important role in electron transport , neurotransmitter synthesis , collagen cross - linkage , and melatonin production and is an important factor in the coagulation cascade .
toxicity associated with abnormal metaboli... | introduction . outside of wilson 's disease ,
abnormal copper metabolism is a rare condition . in pregnancy ,
excess copper levels can be associated with intrauterine growth restriction , preeclampsia and neurological disease .
case report . a 32 year old gravida 4 para 2012 with an obstetrical history co... |
xylene ( aromatic hydrocarbon ) has been widely used as a de - alcoholization agent of choice , in spite of its toxicity to laboratory personnel and the danger it poses to the environment .
the toxic effects of xylene include acute neurotoxicity , cardiac and kidney injury , cancer , blood dyscrasias , skin diseases ... | background : the commonly used clearing agent , xylene is supposed to be highly toxic and carcinogenic .
as previous research studies have shown the effectiveness of different vegetable oils as clearants , this study was designed to evaluate the efficacy of coconut oil.materials and methods : two equal halves of 60 s... |
phylogeny reconstruction and homology - based annotation are two of the most common modeling procedures in biology .
both of them require the assembly of accurate multiple sequence alignments ( msa ) . in this work
, we introduce a web server dedicated to 3d structure - based multiple rna sequence alignment using t... | this article introduces the sara - coffee web server ; a service allowing the online computation of 3d structure based multiple rna sequence alignments .
the server makes it possible to combine sequences with and without known 3d structures .
given a set of sequences sara - coffee outputs a multiple sequence alignm... |
diagnosis of creutzfeldt - jakob disease ( cjd)1 is often challenging in elderly individuals because the various symptoms of this condition overlap with other conditions that are common in this population , such as alzheimer s disease or dementia with lewy bodies.2 however , we have had a patient who presented with aty... | diagnosis of creutzfeldt - jakob disease ( cjd ) is often challenging in elderly individuals , not only because of its variable clinical features but also because of nonspecific changes on the electroencephalogram ( eeg ) in the early stages of the disease . here
we report on a patient who presented with progressive ... |
in recent years , various uses of wax and fat microspheres in the pharmaceutical field have come into forefront , involving the microspheres technology .
the goal of any drug delivery system is to provide a therapeutic amount of drug(s ) to the proper site in the body in order to promptly achieve and thereby to maint... | the purpose of the present study was to compare the in vitro release and to find out whether the bioavailability of a 75 mg indomethacin capsule ( microcid sr ) was equivalent to optimized formulation ( indomethacin - loaded cetyl alcohol microspheres ) .
indomethacin - loaded cetyl alcohol microspheres were prepare... |
the most common location is the mesentery , followed by the omentum , mesocolon and retroperitoneum1 - 3 ) .
although approximately 60% of these patients are younger than 5 years , a significant number of abdominal lymphangiomas do not manifest until adulthood1 ) .
regardless of the diagnostic modalities used , the... | cystic lymphangioma of the gallbladder is quite a rare tumor with only a few cases having been reported in the literature .
we describe here a rare case of cystic lymphangioma of the gallbladder , which was unusual in that the patient presented with biliary pain and an abnormal liver test .
ultrasonography and comp... |
creating an extraocular aqueous humour filtration is still the most popular surgical strategy in glaucoma worldwide . however , because of the well known bleb - related problems , a quest for new bleb - free procedures has been pursued for several years .
for example , canaloplasty ( cp ) and the trabeculocanalicul... | the results of canaloplasty ( cp ) and hydrus microstent ( hm ) implantation were retrospectively compared at 24 months ' follow - up in a cohort of subjects referred to our institution for uncontrolled iop in primary or secondary ( e.g. , pseudoexfoliative and pigmentary ) open - angle glaucoma .
the outcome was lab... |
breast cancer is one of the most common malignancies and has become a serious threat to women s health around the world . in 2012,1.67 million women
were diagnosed with breast cancer worldwide , accounted for 25.2% of all cancers among women . meanwhile
, 522,000 women died of breast cancer which accounted for 14.7... | objectiveto assess the incidence , mortality and survival status of female breast cancer in jiangsu province of china.methods population - based cancer registry data in jiangsu province were collected during 2003 - 2011 .
crude rates , age - specific rates , age - standardized rates and annual percent changes of inci... |
thoracic endovascular aortic repair ( tevar ) could reduce perioperative mortality and pulmonary , cardiac and renal complications when compared to open repair .
furthermore , most of the past series data included devices that will soon not be marketed anymore . in an ironic way , these data are loosing their value e... | introductioncurrent strategies for repair of descending thoracic aortic aneurysms consist of open repair with surgical graft replacement or thoracic endovascular aortic repair .
we review and update our overall experience in aortic thoracic diseases and specifically analyzed our outcomes with thoracic endovascular ao... |
affect data were collected from 554 residents ( 71 % female ) of a large , urban geriatric center as part of a longitudinal study . mean age for the sample was 83.3 years ( sd = 6.0 ) .
sixty - nine percent of the participants resided in apartments and 31 % resided in the nursing home .
the philadelphia geriatric c... | generally , depression is thought of in terms of negative affect however , in the following paper , the contribution of positive affect ( pa ) , as well as negative affect ( na ) , is demonstrated in the recognition of clinically significant depression .
affect and depression data were collected from 554 residents of... |
fifty years of development and progress have led to people with hemophilia having access to potentially unlimited supplies of therapeutic products , in the form of coagulation factor concentrates ( cfcs ) safe from historical hazards . despite this
, emerging evidence of subclinical bleeding with current prophylactic... | following the obviation of the pathogen safety threats posed by previous generations of clotting factor concentrates for the treatment of hemophilia , the principal issue facing the patient community is timely access to adequate supplies of continuously improving therapies .
the application of evidence - based medici... |
metaplastic breast carcinoma ( mbc ) is rare with an incidence less than 1% of all breast malignancies .
it denotes tumors with mixed primary epithelial and sarcomatous components as well as mixed adenocarcinoma with squamous cell carcinoma and tends to be larger in size when diagnosed , with higher tumor grade and t... | abstractmetaplastic breast carcinoma ( mbc ) is a rare type of breast carcinoma .
recurrence presenting as chest wall invasion is common but rarely as metastasis to distal skeletal muscle in which most patients present with a painful mass .
herein , we report a rare case of 65-year - old woman , with mbc and recurr... |
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