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the cloudsat 2cice product describes the vertically resolved microphysical properties of ice clouds [ deng et al . , 2010 , 2013 ] . the algorithm is a synergetic ice cloud retrieval derived from the combination of the cloudsat radar reflectivity ( ze ) and the cloudaerosol lidar and infrared pathfinder satellite obs...
abstractthe cloudsat 2cice data product is derived from a synergetic ice cloud retrieval algorithm that takes as input a combination of cloudsat radar reflectivity ( ze ) and cloudaerosol lidar and infrared pathfinder satellite observation lidar attenuated backscatter profiles . the algorithm uses a variational metho...
cough variant asthma ( cva ) , a variant form of classic asthma that presents solely with a cough and responds to bronchodilator treatment , is considered to be the most common cause of chronic coughs . several studies have suggested that the fundamental pathophysiological characteristics of cva , airway inflammation...
objective . this study aimed to investigate improvements in inflammatory mediator levels in induced sputum and airway hyperresponsiveness ( ahr ) in cough variant asthma ( cva ) during long - term inhaled corticosteroid ( ics ) treatment . patients and methods . patients with cva ( n = 35 ) and classic asthma ( n =...
childhood obesity is related to a wide range of psychosocial and physical problems resulting in larger health care costs [ 2 , 3 ] . since obesity , once established , is difficult to treat , prevention is the main priority and is therefore receiving increasingly more attention . traditionally , the prevention and ...
background . integrated community - wide intervention approaches ( icias ) are implemented to prevent childhood obesity . programme evaluation improves these icias , but professionals involved often struggle with performance . evaluation tools have been developed to support dutch professionals involved in icias ....
only 10% to 20% of tumors are resectable at the time of diagnosis , and even in these patients , survival beyond 5 years can be anticipated in no more than 10% . these data underscore the importance of an optimal palliation that will guarantee the shortest possible hospital stay and as long a survival as possible wit...
only 10% to 20% of pancreatic tumors are resectable at the time of diagnosis . patients with advanced disease have a median survival of 4.9 months . palliation is often required for biliary or duodenal obstruction , or both , and for pain . optimal palliation should guarantee the shortest possible hospital stay a...
the question of why one person develops high blood pressure ( bp ) and another does not has long been controversial . for example , freud in the 1930s hypothesized that keeping one 's anger in will cause bp to rise . theories of stress and disease came a bit later , and a multitude of experimental and field studies...
chronic stress has been linked to hypertension , but the underlying mechanisms remain poorly specified . we suggest that chronic stress poses a risk for hypertension through repeated occurrence of acute stressors ( often stemming from the chronic stress context ) that cause activation of stress - mediating physiologica...
participants aged between 4 and 50 years with type 1 diabetes on insulin pump therapy with impaired awareness of hypoglycemia participated in a 6-month intervention trial comparing standard pump therapy ( insulin pump only ) to the veo ( insulin pump with continuous glucose monitoring and lgs function ) . hypoglycemi...
objectivethe advent of sensor - augmented pump therapy with a low - glucose suspend ( lgs ) function ( medtronic paradigm veo system ) , allowing insulin to be automatically suspended for up to 2 h when sensor glucose falls below a preset threshold , has the potential to reduce the duration of hypoglycemia . in this ar...
transepithelial elimination of granulomas has been reported in the past ; however , transfollicular elimination has not found a mention in the dermatologic literature . herein we report this curious phenomenon and correlate it with the clinical features of this condition . a 43-year - old male presented with an asy...
a patient presented with a an asymptomatic brown to erythematous , scaly indurated solitary plaque on his elbow . the lesion was diagnosed as lupus vulgaris on the basis of clinical features and biopsy findings . the histopathology further revealed a granuloma within the follicular infundibulum , which was possibly...
improved treatment strategies and better supportive care have resulted in increased survival rates for most childhood cancers . currently , close to 80% of children and adolescents with cancer will survive 5 years or more after diagnosis . in the usa , they are at risk for developing secondary neoplasm , cancer rec...
improved treatment strategies and better supportive care have resulted in increased survival rates for childhood cancers . however , most of the survivors may have complex , long - term health issues . in 2004 , childhood cancer survivorship study of the united states confirmed that both survivors and the medical com...
a 55-year - old woman was referred to our institution with sudden onset of chest pain . she had a history of percutaneous vertebroplasty at the 12th thoracic vertebra for osteoporotic fracture 3 weeks before she was referred to the institution . an electrocardiogram ( ecg ) did not show st - segment elevation ; sin...
a 55-year - old woman who had a history of percutaneous vertebroplasty was referred to our institution with sudden onset of chest pain . computed tomography ( ct ) scan demonstrated a long , linear , highly - attenuated segment in the right side of the heart and fragmented pieces in the right pulmonary artery . the c...
the study protocol was reviewed and approved by the ethical committee of the barcelona health institute . during the 200910 influenza season , the sentinel network of primary care physicians and pediatricians of navarre obtained nasopharyngeal swab specimens from patients with influenza - like illness ( ili ) for vir...
of 233 households with laboratory - confirmed pandemic ( h1n1 ) 2009 in navarre , spain , only 64% ( 107/166 ) of contacts with influenza - like illness had sought medical care . this value was lower for adults ( 53% , 39/74 ) than for children < 15 years of age ( 74% , 68/92 ) , as well as for those with cases secon...
fine needle aspiration cytology ( fnac ) of the thyroid gland is firmly established as a first - line diagnostic test for the evaluation of goiter and as the single most effective test for preoperative diagnosis of lesions of the thyroid gland . recent studies have also confirmed that fnac is more sensitive as well a...
background : fine needle aspiration cytology ( fnac ) of the thyroid is an established first - line test for thyroid lesions . marginal vacuoles ( mvs ) have been associated with hyperactivity of the thyroid , but some studies have pointed towards their nonspecific status.aims:to assess the presence of mvs in diffuse t...
the kidney seems more sensitive to the chronic effect of cadmium than the lung . only minor impairments of lung function ( mild form of obstructive lung disease ) were found after long - term occupational exposure ( less than 20 yr ) to moderate concentration of cadmium oxide dust and fume . this conclusion , can n...
hemoptysis is one of the symptoms of pulmonary diseases such as parenchymal diseases ( like infections ) and endobronchial lesions ( like tumors ) as well as vasculitis ( like wegener s disease and anti - glomerular basement membrane disease ) . based on its severity , hemoptysis is classified as mild , moderate , an...
background : hemoptysis occurs due to either pulmonary diseases or bronchoscopy interventions . the aim of the present study was to compare the efficacy of the endobronchial instillation of adrenaline with that of tranexamic acid.methods:fifty patients were randomly selected as 2 double - blinded sample groups ( n=25 )...
according to the 2010 national survey on drug use and health , 20 percent of us adult population ( 45.9 million ) were estimated to have mental illness in 2010 : 3.8 percent had suicidal ideation ( 8.7 million ) ; 20 percent of the general population ( 9.2 million ) with mental illness met criteria for substance abuse ...
medical students experience higher rates of mental illness than the general population . with competition rising for success in medical school , and residency , increasing incidence of distress are leading this population to experience higher rates of thoughts of dropping out of school , and even suicide . since many...
metabolic syndrome ( syndrome x , insulin resistance syndrome ) consists of constellation of metabolic abnormalities which include central obesity , hyperglycemia plus insulin resistance , high triglycerides plus low hdl cholesterol , and hypertension ( the deadly quartet ) . third national health and nutrition exami...
objective : we evaluated the thyroid function tests in individuals with metabolic syndrome to explore the possibility of thyroid receptor resistance.materials and methods : the study was a cross - sectional study . it included 40 patients ( group i ) and 20 healthy individuals served as controls ( group ii ) . patien...
a left renal vein passing behind the abdominal aorta is termed a retroaortic left renal vein ( rlrv ) , and this anomaly is a relatively uncommon condition . recent advances in computed tomography and magnetic resonance imaging techniques make it possible to visualize the vascular structures in detail . additionall...
purposea retroaortic left renal vein ( rlrv ) is located between the aorta and the vertebra and drains into the inferior vena cava . urological symptoms can be caused by increased pressure in the renal vein . to evaluate the clinical importance of rlrv , we reviewed patients ' medical records and radiologic finding...
over the past few decades , percutaneous coronary intervention ( pci ) has become one of the most common medical procedures for patients with coronary artery disease . the benefits of pci are mainly attributable to a reduction of myocardial ischemia . however , noninvasive tests of myocardial ischemia are limited by ...
background : fractional flow reserve ( ffr ) is currently considered as the gold standard for evaluating the functional significance of coronary stenosis . however , its potential benefits in real - world practice remain unknown in china . this study aimed to test the hypothesis that the use of ffr is associated with...
lack of effective cancer treatments and the emergence of drug resistance in progressively growing tumors make cancer immunotherapy a viable alternative to treat and manage metastatic diseases . synthetic peptide - based vaccines that are capable of inducing specific t cell - mediated immunity are emerging as attracti...
a successful cancer vaccine needs to overcome the effects of immune - suppressor cells such as treg lymphocytes , suppressive cytokine - secreting tr1 cells , and myeloid - derived suppressor cells ( mdscs ) , while enhancing tumor - specific immune responses . given the relative poor efficacy associated with current...
the use of natural and artificial substances has increased during the past few decades , which indicates the incidence of a new problem in physical and social health . the term addicted individual can be defined as one who has a very strong desire toward the use of addictive substances , regardless of their consequ...
background : substance dependency is one of the biggest problems and worries of the world . it stunts the growth of society and causes various problems such as reduction in public health , increase in mortality , rise in social and domestic traumas , loss of educational and occupational opportunities , involvement with...
clinical reasoning ( cr ) is one of the most crucial competencies that a physician should achieve . most of specialty societies , licensing bodies and medical schools consider it in the list of competencies that their graduates should attain and they try to ensure its mastery in the learners . many factors may infl...
background : clinical reasoning is one of the most important competencies that a physician should achieve . many medical schools and licensing bodies try to predict it based on some general measures such as critical thinking , personality , and emotional intelligence . this study aimed at providing a model to design ...
cutaneous t - cell lymphoma ( ctcl ) is a rare group of mature t - cell lymphomas primarily presenting in the skin . between 2000 and 3000 new cases of ctcl occur in the us each year , with mycosis fungoides ( mf ) being the predominant subtype.1 skin manifestations of mf include patches , plaques , tumors , and eryt...
the most common subtypes of primary cutaneous t - cell lymphoma ( ctcl ) are mycosis fungoides and szary syndrome . clinical manifestations and prognosis in ctcl are highly variable . improving the management of this incurable disease with limited toxicity is an active area of research . romidepsin is a novel , wel...
proton pump inhibitors ( ppis ) are a class of drugs that are routinely used in children ; however , stability data for extemporaneous liquid formulations are not readily available for many of these compounds . in a prospective study performed by lugo et al . , which included 21 children 's hospitals , an oral suspensi...
an lc - ms / ms method was developed and validated to be used as a stability indicating assay for the study of a 3 mg / ml lansoprazole oral suspension . the method utilizes a uplc ( ultra - performance liquid chromatography ) column and unique mass spectrometric detection ( ion - trap time - of - flight ( it - tof ...
chronic obstructive pulmonary disease ( copd ) , a disorder of chronic airflow limitation ( chronic airflow obstruction ) not reversed by bronchodilators , is now the 3 commonest cause of death worldwide . while most of the information on copd prevalence , morbidity , and mortality is available from high - income cou...
objective : acute exacerbations of chronic obstructive pulmonary disease ( aecopd ) cause significant morbidity , mortality , and an inexorable decline of lung function . data from developed countries have shown viruses to be important causes of aecopd , but data from developing countries like india are scant . we ...
darier 's disease ( dd ) , described independently by darier and white in 1889 , is an autosomal - dominant disease characterized by persistent eruption of hyperkeratotic papules , histological examination of which shows suprabasal acantholysis with distinct overlying dyskeratosis . dd is caused by mutation in the at...
darier 's disease is an uncommon genodermatosis characterized by keratotic papules in seborrheic distribution . the disease can rarely present in unilateral zosteriform pattern , as a mosaic form following the blaschko 's line . we present a 35-year - old woman with zosteriform pattern of darier 's disease over rig...
uterine rupture rarely occurs during pregnancy , but it is a critical obstetric complication associated with maternal and fetal mortality and morbidity.1 it is known that the rate of uterine rupture increases in patients with a history of uterine surgery , such as cesarean section or myomectomy . it is however , not ...
uterine rupture rarely occurs during pregnancy , but it is a critical situation if so . it is already known that a history of uterine surgeries , such as cesarean section or myomectomy , is a risk factor for uterine rupture . currently , the laparoscopic adenomyomectomy is a widely performed procedure , but associate...
long - range electron transfer ( et ) is a crucial step in many energy conversion processes and biological redox reactions in living organisms . we show that newly developed x - ray pulses can directly probe the evolving oxidation states and the electronic structure around selected atoms with detail not avail...
tracheoesophageal fistula ( tef ) is a congenital or acquired life threatening complication of a communication between the esophagus and the tracheobronchial tree or the other mediastinal structures , due to pathological conditions affecting these structures . the most common etiology of nonmalignant acquired tef is ...
a case of acquired tracheoesophageal fistula ( tef ) is presented in a 44-year - old female who presented with acute respiratory failure due to bilateral aspiration pneumonia . the patient had persistent air leak while on mechanical ventilation and underwent bronchoscopy which revealed the above etiology . histopat...
inguinal hernia repair is one of the most commonly performed surgical procedures with approximately 20 million inguinal herniorrhaphies repairs performed yearly around the globe . the operative approach to inguinal herniorraphy overtime has evolved from primary tissue - based repairs to open tension - free mesh repai...
laparoscopic inguinal herniorraphy is a commonly performed procedure given the reported decrease in pain and earlier return to activity when compared with the open approach . moreover , robotic assistance offers the operating surgeon considerable ergonomic advantages , making it an attractive alternative to conventio...
les indices de pharmacorsistance ( ipr ) quantifient leffet cumulatif de la rsistance antimicrobienne sur la probabilit quun pathogne donn soit susceptible un traitement antimicrobien . driver lipr des infections urinaires dorigine non nosocomiale causes par lescherichia coli en colombie - britannique entre 2007 et ...
typically , rates of resistance to various antibiotics in a given pathogen are assessed for a single drug at a time , in the setting of a particular type of infection . a more cohesive analysis is the drug resistance index , which incorporates resistance to multiple drugs for a given pathogen . the authors of this ...
stroke is the major cause of chronic disability and the third leading cause of death in humans after cancer and coronary heart disease in developed countries . because stroke causes severe neurological complications , new strategies for patients suffering from stroke are needed . the capacity for neuroprotection depe...
apoptosis after global or focal cerebral ischemia plays a crucial role in mediating cell death . in this study , we observed the time point expression of physiologic events involving apoptosis regulatory proteins after photochemically - induced focal cerebral ischemia in sprague - dawley rats . protein expression was...
rising interest in health and regular medical checkups have promoted detection of early cancer . likewise , in stomach cancer , detection rates for early stages are higher than those for progressive cancer . traditionally , gastrectomy has generally been regarded as the standard therapy for treatment of gastric cance...
nowadays , endoscopic mucosal resection or endoscopic submucosal dissection has shown effectiveness equivalent to that of gastrectomy and has emerged as a popular technique for curative treatment of gastric cancer . however , noncurative resection or resection beyond the indication may lead to lymphatic and extended or...
worldwide , more than 4 million people each year are estimated to have a non - st - segment elevation myocardial infarction ( nstemi ) , and long - term mortality is higher in patients with non - st - elevation acute coronary syndrome ( acs ) than in those with st - elevation acs . in clinical practice , for patients w...
background : in cardiology , it is controversial whether different therapy strategies influence prognosis after acute coronary syndrome . we examined and compared the long - term outcomes of invasive and conservative strategies in patients with non - st - segment elevation myocardial infarction ( nstemi ) and charact...
surgery for pancreatic cancer is probably the most demanding and risky operative procedure in abdominal surgery . remarkable progress has been achieved during the last three decades and pancreatic surgery can nowadays be performed safely with low morbidity and mortality in various specialized hospitals around the wor...
background . for m1 pancreatic adenocarcinomas pancreatic resection is usually not indicated . however , in highly selected patients synchronous metastasectomy may be appropriate together with pancreatic resection when operative morbidity is low . materials and methods . from january 1 , 2004 to december , 2007 a tot...
benzo[a]pyrene ( b[a]p ) , a polycyclic aromatic hydrocarbon compound , is produced by incomplete combustion of organic compounds and high - pressure processes . this compound is commonly present in motor vehicle exhaust , tobacco smoke , grilled , smoked and broiled foods , and emissions from residential and industr...
the objective of this study was to assess the toxicological effect of exposure to benzo(a)pyrene , b[a]p , on germ cells during spermatogenesis . mice were exposed to b[a]p at 1 , 10 , 50 , and 100 mg / kg / day for 30 days via oral ingestion . germ cells , including spermatogonia , spermatocytes , pachytene sperm...
ectodermal dysplasia , as first described by thurman,1,2 is a hereditary disorder occurring as a consequence of disturbances in the ectoderm of the developing embryo . the triad of nail dystrophy ( onchodysplasia ) , alopecia or hypotrichosis ( scanty , fine light hair on the scalp and eyebrows ) , and palmoplantar h...
ectodermal dysplasia is a hereditary disorder that occurs as a consequence of disturbances in the ectoderm of the developing embryo . the triad of nail dystrophy , alopecia or hypotrichosis and palmoplantar hyperkeratosis is usually accompanied by a lack of sweat glands and a partial or complete absence of primary an...
chronic renal failure is a progressive , irreversible kidney disorder in which the body s ability to maintain liquid and electrolytes is lost ; it is considered a major problem in the health system , and is one of the leading causes of death and inability worldwide ( 1 ) . the prevalence of chronic renal failure is 2...
backgroundanxiety is the most common mental disorder in end - stage renal disease patients . the use of aromatherapy as a treatment for anxiety has increased substantially in most countries.objectivesthis study aimed to investigate the effect of inhaling rose water aromatherapy on anxiety in hemodialysis patients.met...
curing a medical disease generally implies completely removing the pathogenic agents : e.g. , killing microbes with specific antibiotic therapy or surgically removing cancer . in t1d , cure implies reversing new - onset t1d and restoring glucose homeostasis . initial surgical success using the edmonton protocol in is...
type 1 diabetes ( t1d ) is characterized by specific destruction of pancreatic insulin - producing beta cells accompanied by evidence of beta - cell - directed autoimmunity such as autoreactive t cells and islet autoantibodies ( iaas ) . currently , t1d can not be prevented or reversed in humans . t1d is easy to pr...
of all the functional groups in organic chemical space , the olefin must be regarded as one of the most privileged from the vantage point of utility in synthesis . as a result , methods for olefin synthesis and functionalization have been extensively developed and applied in both academic and industrial sectors . m...
the excision of hydrogen from an aliphatic carbon chain to produce an isolated olefin ( desaturation ) without over - oxidation is one of the most impressive and powerful biosynthetic transformations for which there are no simple and mild laboratory substitutes . the versatility of olefins and the range of reactions ...
juxtaglomerular cell tumor ( jgct ) , also known as reninoma , is an extremely rare kidney tumor of the juxtaglomerular cells that typically secrete renin . it was first described , in 1967 , by robertson et al . , and was first named , in 1968 , by kihara et al . since then , approximately 100 case reports have been...
juxtaglomerular cell tumor ( jgct ) is an unusual mesenchymal entity of the kidney . it is a benign renin - secreting tumor causing hypertension and hypokalemia due to secondary hyperaldosteronism . it is curable if it is discovered early and surgically removed , but may cause a fatal outcome usually due to complic...
preterm birth ( ptb ) is a leading cause of neonatal morbidity and mortality , and it is well recognized that the risk decreases with increasing gestational age of delivery . the benefits of antenatal corticosteroid ( acs ) administration to patients at risk of delivery < 34 weeks to mitigate the risks of prematurity...
objectives . antenatal corticosteroids ( acs ) are not routinely administered to patients at risk for delivery between 34 and 36 6/7 weeks . our objective was to determine whether acs are cost - effective for late - preterm infants at risk for imminent preterm delivery . we hypothesized that the preferred strateg...
demand for orthodontic treatment has greatly increased in adults in the recent years . among the types of brackets , metal brackets are the oldest and most commonly used type . porcelain - fused - to - metal ( pfm ) restorations are the most commonly used crowns due to high strength and accuracy of the cast metal and...
objectives : this study sought to assess the effect of bracket base design on the shear bond strength ( sbs ) of the bracket to feldspathic porcelain.materials and methods : this in vitro , experimental study was conducted on 40 porcelain - fused - to - metal restorations and four different bracket base designs were bo...
the study was approved by the medical ethics committee of jinling hospital and adhered to the tenets of the declaration of helsinki . all donor tissues were obtained within 12 h after enucleated eyeballs from healthy young adults with accidental death without any disease . twenty eyes of 17 patients , who are with ...
purpose : the purpose of this study is to compare the outcomes following femtosecond laser - assisted deep anterior lamellar keratoplasty ( dalk ) with 75% of stromal dissection ( predescemetic group ) and femtosecond laser - assisted dalk using big - bubble technique with total stromal resection ( descemetic group ) f...
central retinal artery occlusion ( crao ) leads to severe visual disturbances and is generally resistant to treatment . the fundus changes are characterized by retinal whitening , a cherry red spot , and a pale disc.1 the visual prognosis in eyes with crao is generally very poor , and the degree of visual damage has ...
this paper reports three cases of central retinal artery occlusion ( crao ) with purtscher - like retinopathy and good recovery of visual function . the three cases of crao had similar fundus changes , ie , cotton wool patches surrounding the optic disc and whitening of the retina surrounding the fovea with a cherry ...
neurodegenerative disorders represent a global health problem , being a major cause of high mortality among elderly populations . one of the most common degenerative diseases of the nervous system is parkinson 's disease ( pd ) . it is related to the death of dopaminergic neurons in the basal ganglia of the brain ....
kinin peptides ubiquitously occur in nervous tissue and participate in inflammatory processes associated with distinct neurological disorders . these substances have also been demonstrated to promote the oxidative stress . on the other hand , the importance of oxidative stress and inflammation has been emphasized i...
this evaluation illustrated that without the implementation of an appropriate scaling system , the work - up to rule out pe is of low yield . consequences of excessive testing include unnecessary exposure to radiation and financial wastefulness . the implementation of clinical prediction rules will improve the diagno...
with 200,000 annual deaths in the united states due to pulmonary embolism ( pe ) , efficient and accurate diagnosis is mandatory . since negative d - dimer values are only useful in ruling out pe , elevated values alone should not result in excessive testing . this study assessed the diagnostic and financial yield of...
a lack of comprehensive assessment of pain can lead to poor management or treatment of pain . pain , defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage , or described in terms of such damage ( iasp ) , is a subjective experience and this is taken into account w...
context : nurses are involved in assessment of pain in most clinical settings . pain continues to be underestimated and undertreated.materials and methods : this study assessed the rating of pain severity by nurses who observed the two case scenarios using role plays . the data were computed and frequency distributio...
birth weight is dependent on several parameters , the chief being the gestational age at delivery . of the non - pathological variables , maternal ethnicity , height , and weight , as well as parity definition of small for gestational age baby depends on accurate criteria for expected mean weight and standard deviati...
the objective of this study was to evaluate whether the global reference curves adapted on the basis of who data for india and the hadlock reference curves fit the population in india and to validate the reference curves . the data were retrieved retrospectively from the records of women registration for antenatal ca...
a 30-year - old man was admitted to our clinic with complaints of abdominal pain and fever . he had a history of ewing 's sarcoma diagnosed 18 months earlier on his chest wall and he had undergone pneumectomy with negative excision margins , followed by chemotherapy . on physical examination , his saturation was 91...
gastropleural fistula ( gpf ) is a rare condition that can occur as a consequence of prior pulmonary surgery , trauma , or malignancy . conservative management usually fails , and gastrectomy and even thoracotomy is often required , especially in debilitated patients . we present a patient with gpf who had a histor...
in mid - april 2010 , influenza - like illness was reported in pigs in a north yorkshire gilt ( female pig intended for breeding that has not farrowed ) grower unit of 1,200 animals . gilts were brought into the unit in batches of 100 animals at 5 months of age . the first batch of gilts arrived in mid - january 20...
surveillance for influenza virus in pigs in the united kingdom during spring 2010 detected a novel reassortant influenza virus . this virus had genes encoding internal proteins from pandemic ( h1n1 ) 2009 virus and hemagglutinin and neuraminidase genes from swine influenza virus ( h1n2 ) . our results demonstrate p...
bladder cancer is the second most common malignancy of all genitourinary tumors in the united states and korea . recurrence of bladder cancer is common , and is reported to occur in 50%-70% of cases , and approximately 10%-15% of patients will experience disease progression . detection of bladder cancer when it i...
purposeapurinic / apyrimidinic endonuclease 1/redox factor-1 ( ape1/ref-1 ) is a multifunctional protein that shows elevated expression in a number of cancers . we attempted to determine whether serum ape1/ref-1 is elevated in patients with bladder cancer.materials and methodsserum ape1/ref-1 levels were determined u...
recent years have seen the development of a new class of implicit - solvent models the variational implicit - solvent model ( vism ) . coupled with the robust level - set numerical method , such models allow an efficient and quantitative description of molecular solvation . central in the vism is a mean - field fr...
central in the variational implicit - solvent model ( vism ) [ dzubiella , swanson , and mccammon phys . rev . lett.2006 , 96 , 087802 and j. chem . phys.2006 , 124 , 084905 ] of molecular solvation is a mean - field free - energy functional of all possible solute solvent interfaces or dielectric boundaries . su...
lichen planus ( lp ) is a chronic dermatologic disease that is relatively common among our population . it is most common among middle - aged adults with women predominance ( 3:2 ) ratio over men . this article focuses on the prevalence of oral , skin , and oral and skin lesions of lp . a study was conducted in t...
background : lichen planus ( lp ) is a mucocutaneous disease that is relatively common among adult population . lp can present as skin and oral lesions . this study highlights the prevalence of oral , skin , and oral and skin lesions of lp.aims:the aim of this study was to evaluate the prevalence of oral , skin , a...
diabetes is one of the most common disorders worldwide , and its prevalence is estimated to increase by 122% from 1995 to 2025 ( 1 ) . due to the increasing prevalence of diabetes , factors related to diabetes and its complications have become increasingly important ( 2 , 3 ) . appropriate care , including controll...
background : diabetes is one of the most serious metabolic disorders to affect different organs in the body . patients with diabetes are hence at risk of developing other problems . urinary tract infections ( uti ) are one of the problems that occur more commonly in diabetic patients than in others . there are se...
androgenic alopecia ( aga ) is the most common hair loss condition in men and women with significant negative impact on their social and psychological wellbeing . aga , a hereditary androgen - dependent disorder , is characterized by a progressive process that causes a gradual conversion of terminal hair into miniatu...
background : androgenic alopecia ( aga ) is a common cosmetically and psychosocially distressing condition . high androgen level contributes to the development of atherosclerosis , thrombosis leading to hypertension and hypercholesterolemia.objectives:to study the clinico - epidemiological profile of aga and the pres...
oral contraceptive - induced menstrual migraine ( ocmm ) is a menstrual migraine subtype mainly caused by estrogen withdrawal occurring during the week of pill suspension [ 1 , 2 ] . ocmm is a poorly studied , but particularly severe and disabling form of menstrual migraine ; it is codified by the ichdii classificati...
oral contraceptive - induced menstrual migraine ( ocmm ) is a particularly severe form of migraine triggered by the cyclic hormone withdrawal . to review the efficacy of frovatriptan vs. other triptans , in the acute treatment of ocmm through a pooled analysis of three individual randomized italian studies . with or wi...
lichen planus is a chronic inflammatory mucocutaneous disease of unknown etiology that frequently involves the oral mucosa . the disease affects skin and mucosa in prevalence estimated between 0.5 and 2.0% of the population with predilection for females and a mean age at onset in the fourth or fifth decade 1 . abou...
lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology . it is characterized by a cell - mediated immunological response to induced antigenic change in skin and/or mucosa . the possible malignant transformation of lichen planus remains a subject of controversial discussions in the lite...
cerebral venous and sinus thrombosis is a rare condition accounting for < 1% of all strokes.7 ) its annual incidence is estimated at three to four cases per one million members of the population , most often affecting young adults and children.19 ) in adults , the peak incidence is in their third decade , and approxima...
superior sagittal sinus thrombosis ( ssst ) is an uncommon cause of stroke , whose symptoms and clinical course are highly variable . it is frequently associated with a variety of hypercoagulable states . coagulation abnormalities are commonly seen in patients with hyperthyroidism . to the best of our knowledge , ...
myofascial release has been commonly regarded as a therapeutic , post - exercise technique aimed towards repair and recovery ( 1 , 2 , 18 , 22 ) . more recently , myofascial release has been regarded as a performance enhancing , pre - exercise technique within the athletic population ( 19 , 24 ) . this current pre ...
recent developments in the strength and conditioning field have shown the incorporation of foam rolling self - myofascial release in adjunct with a dynamic warm - up . this is thought to improve overall training performance ; however , minimal research exists supporting this theory . therefore , determining if an a...
severe hyperkalemia during orthotopic liver transplantation , is very dangerous , and needs vigilant monitoring of serum potassium and acute management of the hyperkalemia . the causes of hyperkalemia during different stages are ; 1 ) extracellular shift in exchange for h during severe metabolic acidosis in an - hepa...
a serious hazard to patients during orthotopic liver transplantation is hyperkalemia . although the most frequent and hazardous hyperkalemia occurs immediately after reperfusion of the newly transplanted liver , morbid hyperkalemia could happen in the other phases during orthotopic liver transplantation . however , p...
human saliva is a biological fluid with myriad of biological functions important for the maintenance of oral and general health . it is a plasma ultra - filtrate containing proteins either synthesized in situ from blood or in the salivary glands 1 . major salivary glands consisting of submandibular glands , subling...
human saliva plays a pivotal role in digesting food and maintaining oral hygiene . the presence of electrolytes , mucus , glycoproteins , enzymes , antibacterial compounds , and gingival crevicular fluid in saliva ensures the optimum condition of oral cavity and general health condition . saliva collection has been...
vitamin k is a fat - soluble vitamin existing mostly in nature and comprises vitamin k1 ( phylloquinone ) , contained mostly in deep green vegetables , and vitamin k2 ( menaquinone ) , found mainly in meats , dairy , fish , and fermented foods . the classic role of vitamin k is as a cofactor for the enzyme gamma - gl...
this study was conducted to validate a food frequency questionnaire ( ffq ) to assess vitamin k intake in clinical and research settings based on data from the fifth korea national health and nutrition examination survey ( knhanes v ) . we collected a subset of data on informative food items using the 24-hour recall ...
ehlers danlos syndrome ( eds ) is a group of inherited connective tissue disorders caused by a defect in collagen synthesis . the clinical presentation varies widely based on the type of eds.1 joints , skin and blood vessels are typically affected , the latter being the problem in the case presented in this paper . ...
objectivein this case report we describe a successful interdisciplinary approach ( including flow redirection and endovascular occlusion ) applied to a patient with a continuously growing extracranial giant aneurysm of the right internal carotid artery ( ica ) due to known ehlers danlos syndrome.case presentationa 42...
in africa , trypanosomosis is a tsetse - transmitted disease which represents the most important constraint to livestock production . several indigenous west african taurine ( bos taurus ) breeds , such as the longhorn ( n'dama ) cattle are well known to control trypanosome infections . this genetic ability named "...
the philippine archipelago , consisting of about 7107 islands , is a center of endemicity and biodiversity where a large number of endemic plants have been reported to exhibit medicinal properties . previous ethnobotanical studies of medicinal plants in this country were conducted in the archipelagos of batanes and v...
aim : euphorbia hirta is the most widely used plant in the folkloric treatment of dengue in the philippines . this study documents the anecdotal uses of e. hirta in the treatment of dengue in 3 indigenous communities in pangasinan from april to june of 2015.materials and methods : the number of use reports pertaining...
among the different human cell types , janus kinase ( jak)/signal transducer and activator of transcription ( stat ) signaling cascades transduce signals of more than 50 cytokines and peptide hormones . a subset of these growth factors such as prolactin ( prl ) , growth hormone ( gh ) , leukemia inhibitory factor ( lif...
since its discovery as just another kinase more than twenty years ago , the family of jak tyrosine kinases and their respective signal transducers and activators of transcription ( stats ) has been a center of attention in the areas of signal transduction , development , and cancer . the subsequent designation of jak...
endothelial injury has been studied in septic and non - septic patients , both at risk for and with established acute lung injury ( ali ) and acute respiratory distress syndrome ( ards ) . several clinical studies have demonstrated that circulating levels of angiopoietin-2 ( ang-2 ) , which are associated with mortal...
backgroundto determine whether initial reactive oxygen species ( ros)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 ( ang-1 ) , angiopoietin-2 ( ang-2 ) , and von willebrand factor ( vwf ) reflecting endothelial cell injury , we investigated ...
the prognosis is bleak with the median survival in advanced disease around four months from diagnosis . survival compares unfavourably with other european countries and the usa [ 1 , 2 ] . it has often been felt that the scottish lung cancer population has more comorbidity with poorer performance status thus presen...
background . prediction of survival in patients diagnosed with lung cancer remains problematical . the aim of the present study was to examine the clinical utility of an established objective marker of the systemic inflammatory response , the glasgow prognostic score , as the basis of risk stratification in patients ...
atypical antipsychotics are believed to reduce the risk of extrapyramidal syndrome , including tardive dyskinesia ( td ) . quetiapine is reported to be less likely to induce td side effects and , in fact , has been shown to relieve symptoms of severe td1 ) and reduce td risk.2 ) quetiapine 's low affinity and fast di...
the atypical antipsychotics were believed to induce less extrapyramidal syndrome , including tardive dyskinesia ( td ) . since the introduction of the quetiapine , it is also reported with less td side effects . it even can relieve the symptoms of severe td and reduce the risk of td . the quetiapine 's low affinity...
india is estimated to have an adult ( 1549 years ) human immunodeficiency virus ( hiv ) prevalence of 0.27% in 2011 . adult hiv prevalence among males and females is estimated at 0.32% and 0.22% , respectively . according to the national aids control organisation ( naco ) the adult hiv prevalence at national level ...
background : aids has become chronic illness which is well treated with antiretroviral therapy and management of opportunistic infections ( ois).aims and objectives : the study clinical profile and outcome of human immunodeficiency virus ( hiv ) seropositive patients.materials and methods : this was retrospective obser...
diarrhea is an important childhood infection globally , accounting for 2.5 million deaths in under - five children every year . passage of blood and mucus in stool associated with high - grade fever , tenesmus , and intestinal cramps are common symptoms . arthritis , conjunctivitis , parotitis , intussusception , r...
shigella enteritis remains an important cause of mortality and morbidity in all age groups , in developing as well as developed countries . owing to the emerging resistance to multiple antibiotics among shigella spp . , it has been recognized as a major global public health concern and warrants constant monitoring of...
the standard approach of internal jugular vein ( ijv ) for central venous cannulation ( cvc ) using visual and palpable anatomic landmarks is associated with 95% success rate , but it carries the complications from inadvertent puncture of surrounding structures , including the common carotid artery due to significant v...
background and aims : the true incidence of penetration of the posterior wall ( through - and - through puncture ) of the internal jugular vein ( ijv ) during cannulation is unknown . this may have implications if there is hematoma formation , penetration and/or inadvertent cannulation of an underlying carotid artery...
we aimed to detect the extended - spectrum -lactamases ( esbls ) secreted by clinical strains of escherichia coli at fann university hospital in dakar and to characterize them molecularly . we identified 32 isolates producing esbls . the ctx - m-15 gene was the most frequently detected esbl gene , detected in 90.63...
pioglitazone is an established insulin sensitizer hugely successful in therapeutic management of type 2 diabetes mellitus . the beneficial effects extend beyond glycemic control and have positive effects on lipid metabolism , blood pressure , endothelial function , adiponectin , and c - reactive protein levels . pi...
pioglitazone - induced heart failure is known in patients with underlying heart disease , but is not well documented in patients with normal left ventricular function . pioglitazone has been very popular as it is an insulin sensitizer and insulin resistance is prevalent among indians . fluid retention exacerbates p...
chronic helicobacter pylori infection is causally associated with gastritis , gastroduodenal ulcer disease , gastric adenocarcinoma and mucosa - associated lymphoid tissue lymphoma . a genome - wide association study ( gwas ) of anti - h . pylori serologic status among europeans identified inverse associations with s...
a genome - wide association study among europeans related polymorphisms of the tlr locus at 4p14 and the fcgr2a locus at 1q23.3 to helicobacter pylori serologic status . we replicated associations of 4p14 but not 1q23.3 with anti - h . pylori antibodies in 1,402 finnish males . importantly , our analysis clarifie...
malignant ascites ( ma ) , defined as the abnormal accumulation of cancer - containing fluid in the peritoneal cavity , is a sign of peritoneal carcinomatosis.1 it is caused by a variety of primary abdominal and extra - abdominal cancers . the former category mainly includes gastric cancer ( gc ) , colorectal cancer ...
purposethe aims of this study are to establish a new method for simultaneously detecting the interactions between cancer cells and immunocytes in malignant ascites ( ma ) and to propose a new model for ma classification.methodsa quantum dot ( qd)-based multiplexed imaging technique was developed for simultaneous in sit...
blood is a complex tissue consisting of a very specialized network of circulating immune cells and soluble factors that are the morphological substrate of the human immune response . among immune cells , the monocyte , neutrophil , and natural killer ( nk ) compartments are essential for first - line , innate immune re...
summaryeffective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors . we used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations...
at the present time , synthetic meshes are frequently used in pelvic organ prolapse ( pop ) surgery with very good clinical outcomes . at the same time although rare , these complications can have serious consequences . during the past several years , many reports of complications associated with synthetic meshes hav...
introductionto evaluate the rates of complications of pelvic organ prolapse repair and to determine their risk factors.material and methodsthe study included 677 patients operated for pelvic organ prolapse with trocar guided prolift mesh . patients were followed up within 1 and 3 months . a phone interview was cond...
dermatologists have witnessed the many new successes in psoriasis treatment that are documented by improvement of the psoriasis area and severity index ( pasi ) . it measures four aspects of disease activity , namely reduction of erythema , scaling and infiltration as well as area involved . all components of pasi ...
the making of wax moulages was an exclusive and sought - after art that was primarily used for teaching , but also to document clinical and laboratory research during the first half of the 20th century . applying the technique of moulage - making to document a case of psoriasis improvement for posterity , a moulage o...
epidemiological evidence suggests that cadmium ( cd ) exposure causes pulmonary damage such as emphysema and lung cancer . however , relatively little is known about the mechanisms involved in cd pulmonary toxicity . in the present study , the effects of cd exposure on human fetal lung fibroblasts ( mrc-5 cells ) w...
several clinical trials have investigated the effect of the long - acting anticholinergic bronchodilator , tiotropium bromide ( barnes et al 1995 ) , on lung function and dyspnea at rest ( van noord et al 2000 ; vincken et al 2002 ; casaburi et al 2002 ; celli et al 2003 ; brusasco et al 2003 ; verkindre et al 2006 ) a...
in chronic obstructive pulmonary disease ( copd ) patients tiotropium bromide has been shown to improve forced expiratory volume in one second ( fev1 ) and inspiratory capacity ( ic ) . we investigated whether the mechanism leading to these improvements is related to small airways ventilation heterogeneity , assessed...
the mechanism of transmission of the agent or agents causing sars is not yet fully understood but is probably mainly by droplet secretions , fomites , or person - to - person contact , as much of the transmission in hong kong has been limited to healthcare workers and family members . to date , no evidence of airborn...
severe acute respiratory syndrome ( sars ) is now a global public health threat with many medical , ethical , social , economic , political , and legal implications . the nonspecific signs and symptoms of this disease , coupled with a relatively long incubation period and the initial absence of a reliable diagnostic ...
pheochromocytoma is rare but a critical tumor of chromaffin cells , which is frequently considered in the evaluation of hypertension , arrhythmia , or panic disorder and in the follow - up of patients with particular genetic diseases ( 1 , 2 ) . pheochromocytoma is a one of the potentially fatal causes of childhood h...
pheochromocytoma is one of the potentially fatal causes of childhood hypertension . the study aims to analyze the results of our experiences in pheochromocytomas and the long - term results of its surgical treatment in children . the records of 15 children ( 11 boys , 4 girls ) treated for pheochromocytoma in our u...
with the increasing availability of completely sequenced genomes , comparative genomic approaches are becoming more important to decipher the functions of genes . methods , which are powerful , using the conservation of gene proximity on genomes ( i.e. determining potential operons ) can understand functional associa...
operon structures play an important role in co - regulation in prokaryotes . although over 200 complete genome sequences are now available , databases providing genome - wide operon information have been limited to certain specific genomes . thus , we have developed an odb ( operon database ) , which provides a dat...
hemolysis , elevated liver enzymes , and low platelet count ( hellp ) syndrome is frequently associated with severe form of pre - eclampsia . however , the relationship between 2 symptoms is controversial , and the cause of hellp syndrome is still unknown . but there is a growing consensus that it has a familial te...
a 30-year - old female patient , 18 weeks gestational age , with no prior medical history was admitted to hospital complaining severe right upper quadrant pain . the patient was admitted to intensive care unit ( icu ) after emergency surgery to treat intraperitoneal hemorrhage caused by rupture of liver hematoma . de...
two major pathophysiologic abnormalities underlie most cases of type 2 diabetes ( t2d ) : 1 ) insulin resistance and 2 ) defects in pancreatic -cell function . the current consensus is that both are essential components in disease pathogenesis even if their relative importance , the precise temporal sequence of event...
objectivethis article examines the foundation of -cell failure in type 2 diabetes ( t2d ) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.research design and methodsa group of experts participated in a conference on 1416 october 2013 cosponsored by ...
meningiomas are the second most common central nervous system neoplasm in adults and account for 15 - 20% of all primary brain tumors . although most meningiomas are benign , -10% of meningiomas demonstrate more aggressive clinical behavior , as non - benign meningiomas . the term " chordoid meningiomas " was first...
objectivemeningioma is the second most common primary central nervous system neoplasm . in contrast , chordoid meningioma is rare ; due to the paucity of cases , little is known about its clinical features or treatment outcomes . the objectives of this study were to describe the clinical characteristics and outcomes ...
respiratory tract infections , such as community - acquired pneumonia ( cap ) , acute exacerbation of chronic bronchitis ( aecb ) , or acute bacterial sinusitis , are important causes of morbidity and mortality worldwide . the most frequent causative organism in cap is streptococcus pneumoniae or , less commonly , on...
objective : to investigate the effectiveness , safety , and tolerability of moxifloxacin ( mxf ) ( intravenous [ iv ] or sequential therapy [ iv followed by oral ] ) under daily treatment conditions in a large number of patients with respiratory tract infections.design:patients with a diagnosis of respiratory tract inf...
crowns and fixed partial dentures ( fpds ) are the major prosthodontic treatment modalities for past several decades with factors like esthetics , contact points and pontics playing an important role in varying their design . however , one property of cement retained fixed restorations , retention , has been of prime...
background and aim : convergence angle ( ca ) is one of the major determinant factors in the retention of single as well as multiple units . hence , the aim of the present study was to determine the effect of preparation convergence on the retention of multiple unit restorations.materials and methods : nickel - chrom...
pulmonary rehabilitation ( pr ) has become an integral component in the treatment of chronic obstructive pulmonary disease ( copd ) patients . the short - term effects on improving symptoms , exercise tolerance , and health - related quality of life ( hrqol ) were demonstrated by numerous randomized studies and meta ...
backgroundpulmonary rehabilitation ( pr ) is an important treatment option for chronic obstructive pulmonary disease ( copd ) patients and might contribute to a reduction in exacerbation and exacerbation - related hospitalization rate.methodsin this prospective study , all copd patients that completed a comprehensive p...
rna has the dual capability of serving as a genetic polymer that mediates the inheritance of information and as a catalyst for chemical transformations and is therefore a promising candidate as an ancestral biopolymer . in early protocells , prior to the emergence of an rna replicase , nonenzymatic template...
the nonenzymatic replication of primordial rna is thought to have been a critical step in the origin of life . however , despite decades of effort , the poor rate and fidelity of model template copying reactions have thus far prevented an experimental demonstration of nonenzymatic rna replication . the ov...
the development of an artificial endocrine pancreas ( aep ) , composed of a system of continuous blood glucose monitoring and automated insulin infusion , has been a long sought - after solution in diabetic care . the intravascular approach to both glucose sensing and insulin delivery was abandoned in the late 80s , ...
the aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method . we developed a control algorithm based on ...
in recent years , the demand for herbal remedies in nigeria has been on the rise . yet there are little or no scientific data to support medicinal claims of these herbal formulations . herbals are usually sought after for their health benefits and these have become common medicines in many nigerian homes . it is ...
this study determined the effect of the oral and repeated administration of fijk herbal mixture on rat biochemical and morphological parameters . twenty - four wistar rats were distributed into four groups of 6 . group a served as control and received oral administration of distilled water daily . the experimenta...
hallucinations , predominantly visual in nature , can occur in parkinson disease ( pd ) and are often related to the antiparkinsonian drugs . visual hallucinations are a well - recognized problem . besides visual hallucinations , patients with pd uncommonly experience different forms of hallucinations , such as audit...
abstractauditory musical hallucinations ( amhs ) are rare complex auditory hallucinations in parkinson 's disease ( pd ) that have been limited previously . the characteristics of amhs in pd remain uncertain . we describe a 72-year - old woman with pd who presented with amhs . the amhs occurred after immediate - ...
recently , the importance of quality of life research has been accepted . regardless of the disease process , improving a person 's quality of life has become an important goal of treatment programs . in the pediatric literature , quality of life studies have been largely confined to single disease states . usually...
purpose . to determine the quality of life , associations , and costs of a multidiagnosis group of special needs children . methods . in this cross - sectional survey families were identified from the children 's treatment network , a canadian multisector program for children with special needs . families wer...
cardiotoxicity and associated drug failures in clinical development or even withdrawals from the market contribute significantly to the rising cost of drug discovery and development in the pharmaceutical industry . it has been reported that 28% of drug withdrawals in the usa are associated with negative car...
to identify new cardiac biomarkers , a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol ( iso ) treatment . three serum proteins serum amyloid a ( saa ) , -1-acid glycoprotein ( a1ag ) , and apolipoprotein ...
blunt traumatic rupture of the diaphragm is a serious injury that is often difficult to diagnose . ( 1 ) it is an uncommon injury whose incidence is rising because of the increasing number of road traffic accidents in the last few years , together with better pre - hospital and hospital resuscitation of severely inju...
blunt traumatic diaphragmatic rupture is an uncommon but severe problem that is usually seen in polytraumatized patients including blunt abdomino - thoracic trauma due to road traffic accidents , fall from height and penetrating injuries . regardless of the mechanism , diagnosis is often missed and high index of susp...
the jun activation - domain binding protein 1 ( jab1 ) is initially identified as a coactivator of activator protein ( ap-1 ) transcription factor and found a component of the cop9 signalosome ( csn ) complex , contained modulating signal transduction , gene transcription , and protein stability.12 jab1 interacted with...
the jun activation - domain binding protein 1 ( jab1 ) recognize a potential coactivator of activator protein 1 ( ap-1 ) such as c - fos , c - jun transcription factor and the fifth subunit of the cop9 signalosome complex . also , jab1 activate the c - jun gene resulted cell proliferation . not only a powerful tumo...
the retinal pigment epithelium ( rpe ) performs highly specialized metabolic and transport functions essential for homeostasis of the neural retina ( bok 1993 ) . these include phagocytosis of photoreceptor - shed outer segments , transport of nutrients into and removal of waste products from photoreceptor cells and ...
as the retinal pigment epithelium ( rpe ) ages , a number of structural changes occur , including loss of melanin granules , increase in the density of residual bodies , accumulation of lipofuscin , accumulation of basal deposits on or within bruch s membrane , formation of drusen ( between the basal lamina of the rpe ...
h. pylori eradication is strongly recommended in all patients with atrophic gastritis and peptic ulcer disease , but may also benefit subgroups of patients with dyspepsia , and patients who start with nsaid therapy [ 16 ] . h. pylori eradication therapy is an important component of guidelines concerning these patient...
the treatment of choice of h. pylori infections is a 7-day triple - therapy with a proton pump inhibitor ( ppi ) plus amoxicillin and either clarithromycin or metronidazole , depending on local antibiotic resistance rates . the data on efficacy of eradication therapy in a group of rheumatology patients on long - term...
kikuchi - fujimoto disease ( kfd ) is a rare , benign , self - limiting cervical lymphadenitis . the skin manifestations of our case mimicked systemic lupus erythematosus ( sle ) , but immunofluorescence and serology were negative for it . a paucity of reports in literature with unusual skin manifestations has prom...
kikuchi - fujimoto disease ( kfd ) or histiocytic necrotizing lymphadenitis is a rare , benign , self - limiting disease with unknown etiology characterized by regional lymphadenopathy . a 30-year - old female presented with fever , weakness , multiple joint pain , oral ulcers , erythematous facial rashes , hemorrhagic...