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the natural course of hepatitis c virus ( hcv ) infection , which is transmitted via parenteral route , is modulated by both host and viral factors and typically tends to evolve towards chronicity , which will ensue in approximately 85% of cases following acute infection .
given that this virus affects approximately ... | there is an evidence of neurocognitive dysfunction even in the absence of advanced liver disease in chronic hepatitis c virus ( hcv ) infection .
brain metabolism has been investigated non - invasively using one - dimensional ( 1d ) in vivo magnetic resonance spectroscopy ( mrs ) over three decades . even though high... |
diabetic nephropathy ( dn ) is an important diabetic microvascular complication and the major cause of disability and death .
dn is characterized by albuminuria , glomerular hypertrophy , and progressive accumulation of glomerular matrix , culminating in glomerulosclerosis , tubulointerstitial fibrosis , and progress... | to reveal the expression and possible role of tribbles homolog 3 ( trb3 ) in the incidence of type 2 diabetic nephropathy , we used immunohistochemistry , real - time quantitative pcr , western blot analysis , and enzyme - linked immunosorbent assay ( elisa ) to study the expression of trb3 , extracellular signal - reg... |
for the investigation of hemorrhage after sci the rat can be considered to be a good model as the anatomy of arterial supply is almost an exact match to the human . in both rats and humans ,
the blood supply to the spinal cord is provided by three vessels that run along the spinal cord , namely the ventral ( anterior... | the deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized , and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome .
vascular damage leads to decreased blood flow to the co... |
hollow structure materials exhibit usually extraordinary adsorbing capacities to a wide range of species ( i.e. , metal ions , organic molecules , and biomolecules ) and have found practical applications in catalysis , water treatment , and drug delivery . the hollow nanospheres , because of their unique physical and c... | we report herein a facile method for the preparation of sodium tungsten bronzes hollow nanospheres using hydrogen gas bubbles as reactant for chemical reduction of tungstate to tungsten and as template for the formation of hollow nanospheres at the same time .
the chemical composition and the crystalline state of the... |
in summary , our investigations reveal a close interplay between
the glycopeptide geometry and the antifreeze properties of afgp . both
afgp8 and s - afgp4 can adopt amphipathic structures wherein
the alignment of the carbohydrates onto one face is governed by the
proline content , which imparts rigidity to the... | very little is known about the mechanism
of antifreeze action of
antifreeze glycoproteins ( afgps ) present in antarctic teleost fish .
recent nmr and cd studies assisted with total synthesis of synthetic
afgp variants have provided insight into the structure of short afgp
glycopeptides , though the observati... |
it provides cis - elements , such as promoters and binding motifs , and trans - elements , such as transcriptional factors ( tfs ) .
the promoters of target genes came from two sources : experimental determination and sequence - based computational prediction .
hand curation was applied as a crucial part of the dat... | transcriptional factors ( tfs ) and many of their target genes are involved in gene regulation at the level of transcription . to decipher gene regulatory networks ( grns ) we require a comprehensive and accurate knowledge of transcriptional regulatory elements .
tred ( ) was designed as a resource for gene regulatio... |
the term of stem cells came up to us via histologists in the nineteenth century , who introduced it as a general , abstract term for cells specifically involved in repair or regeneration . with the discovery in the 1950s that bone marrow cells could reconstitute the hematopoietic systems of irradiated individuals , the... | stem cells are a scientific field of interest due to their therapeutic potential
. there are different groups , depending on the differentiation state .
we can find lonely stem cells , but generally they distribute in niches .
stem cells do n't survive forever .
they are affected for senescence .
cancer stem ... |
this paper is based on the topic evaluation of the effects of iranian phase changed material cold vest on the physiological indices in hot and dry temperature in climatic chamber ,
appropriate for those who are interested to understand the body central temperature in which increase in those people who work in hot cl... | background : heat stress is a threat to those who work in high temperatures . the purpose in this study was an examination of the cooling ability of iranian phase change material ( pcm ) cold vest in hot and dry conditions in a climatic chamber.materials and methods : this experimental study was implemented on 12 male ... |
changes in the composition of cell surface glycolipids that take place during malignant transformation have been extensively described .
gangliosides are glycosphingolipids containing sialic acid engaged in a wide variety of biological events that occur at vertebrate 's cell membrane .
they are widely distributed i... | the expression of n - glycolylneuraminic acid forming the structure of gangliosides and/or other glycoconjugates ( hanganutziu - deicher antigen ) in human has been considered as a tumor - associated antigen .
specifically , some reports of 14f7 mab ( a highly specific mab raised against n - glycolyl gm3 ganglioside ... |
balcetis and dunning ( 2010 ) reported five experiments with evidence that desirable objects were judged closer than other objects ; an effect they termed wishful seeing .
every experiment rejected the null hypothesis , thereby indicating evidence of the effect , and such replication across experiments is often take... | a recent study reported evidence of wishful seeing , where observers reported seeing a desired object as being closer than other objects .
a statistical analysis of the experimental findings reveals evidence of publication bias in the study , so the existence of wishful seeing remains unproven . |
major progress has been made over the past 20 years in the understanding of the cognitive consequences of critical illness . in order to expand the knowledge how disease states such as sepsis have a causal impact on the central nervous system and cognition ,
experimental animal models are certainly required . in a pr... | tuon and colleagues have developed an animal model to examine the impact of sepsis on memory in rats .
they report important data that expand the understanding of the cognitive consequences of critical illness .
future research should follow this path of inquiry and extend animal models beyond aversive conditioning... |
due to their power efficiency , brightness , and larger color gamut extremes lasers are ideal light sources for projector applications . a fully coherent source provides an image along the optical axis without the concern of losing focus .
speckle , the granular intensity pattern resulting from constructive and destr... | personal electronic devices such as cell phones and tablets continue to decrease in size while the number of features and add - ons keep increasing . one particular feature of great interest is an integrated projector system .
laser pico - projectors have been considered , but the technology has not been developed en... |
tea tree oil ( tto ) is derived from the paper bark tea tree , which belongs to the family of myrtaceae ; it belongs to two genera , leptospermum and melaleuca .
tto medications have been used for thousands of years by australian aborigines both internally and externally for alleviation of pain and promotion of wound... | this clinical study assessed and compared the efficacy of tea tree oil ( tto ) , an alternative form of medicine , with clotrimazole ( i.e. , allopathy ) and a conservative form of management in the treatment of oral fungal infection.in this interventional , observational , and comparative study , we enrolled 36 medica... |
brain metastasis of uterine leiomyosarcoma ( lms ) is rare ( wroski et al . , 1994 aug , honeybul and ha , 2009 mar , yamada et al .
several case reports suggest a resection of brain metastases of uterine lms could result in longer survival , for which controlling systemic disease is a prerequisite ( wroski et al . ,... | a 48-year - old woman underwent a total abdominal hysterectomy after preoperative diagnosis of multiple uterine leiomyomas .
the histopathological diagnosis was leiomyosarcoma ( lms ) . after 47 months
, multiple lung metastases were detected and resected .
the patient was also diagnosed with pelvic bone metasta... |
nearly 10% of the us population has diabetes mellitus , of whom 90% have type 2 diabetes ( t2 dm ) 1 .
as the condition progresses , metabolic control often can not be maintained with just one agent , and multiple agents are required to treat the later stages of t2 dm .
based on joint guidelines issued by the ameri... | in individuals with advanced type 2 diabetes ( t2 dm ) , combination therapy is often unavoidable to maintain glycaemic control .
currently metformin is considered the first line of defence , but many patients experience gastrointestinal adverse events , necessitating an alternative treatment approach . established t... |
most cases of intrathoracic goiter are asymptomatic and are discovered at chest radiography by chance .
it is difficult to gain a definite diagnosis for malignancy by magnetic resonance imaging ( mri ) and iodine-123-radioisotope ( i - ri ) .
then fluorine-18-fluorodeoxyglucose positron emission tomography ( f - fd... | abstracta 55-year - old woman was referred for a suspicion of mediastinal tumor through plain x - ray photography ( x - p ) . magnetic resonance imaging ( mri ) revealed a 3 cm diameter tumor which seemed to connect to the thyroid and projected into the mediastinum .
a fine needle aspiration biopsy was tried but cou... |
collagen , the most abundant protein in mammal , plays a critical role in tissue development and regeneration by supporting proliferation and differentiation of cells . while fibrous collagens ( e.g. type i , ii ) , in connective tissues give mechanical strength to the tissues , the network - like collagen ( type iv )... | collagen is a major structural component of the extracellular matrix that supports tissue formation and maintenance .
although collagen remodeling is an integral part of normal tissue renewal , excessive amount of remodeling activity is involved in tumors , arthritis , and many other pathological conditions . during ... |
regional anaesthesia has been coming and going since 1885 for surgeries on parts of the body where general anaesthesia is not mandatory and/or perilous to the patient . with the application of ultrasound to regional blocks ,
there is resurgence of regional anaesthesia which can now be administered more precisely with... | background and aims : supraclavicular approach to the brachial plexus may be associated with complications such as pneumothorax , inadvertent vascular puncture , inter - scalene block and neurovascular injuries .
the present study was conceived to find out the variation in depth of brachial plexus to suggest the mini... |
although most mature cystic teratoma ( mct ) occurs in the ovary , some cases of cystic teratoma of extra gonadal origin have been reported .
it is usually found in neonates , and the ovary is most often implanted in the omentum.123 ectopic ovary , used synonymously with accessory ovary , supernumerary ovary , or ova... | autoamputated ovary with mature cystic teratoma ( mct ) is a rarely reported gynecologic entity with an unknown prevalence .
a 34-year - old woman referred to our clinic for presumed left ovarian tumor .
pelvic examination , ultrasonography and computed tomography scan revealed a 5-cm , cystic ovarian mass with cal... |
regional lymph node metastasis ( lnm ) is a well - known prognostic indicator in many types of solid cancer , including head and neck squamous cell carcinomas ( hnscc ) .
lnm negatively influences the overall survival and increases the likelihood of distant metastases . in hnscc ,
the correlation between lnm and di... | purposelymph node metastasis ( lnm ) is a strong prognostic factor in many solid cancers , including head and neck squamous cell carcinomas ( hnscc ) , and lnm can be dependent upon primary tumor biology , as well as tumor dimension . here
, we investigate the relative risk of lnm in accordance to tumor dimension and... |
in middle - aged to elderly patients , a coronary anomaly is often an incidental finding .
the clinical presentation varies from asymptomatic up to presentation as an acute myocardial infarction or even sudden cardiac death ( scd ) .
we present a case of an aberrant right coronary artery ( arca ) and reviewed the l... | abstractbackground : an anomalous right coronary artery originating from the left sinus of valsalva is a rare , but often incidental , finding in middle - aged to elderly people .
prevalence is difficult to define , as well as determining potential harmful hemodynamic consequences .
moreover , the optimal treatment... |
a 44-year - old male patient visited the outpatient department with complaints of a chronic epiphora , and discharge from the right eye .
a palpable mass had been noted in the right medial canthal area 10 days prior to the visit .
on ophthalmological examination , the visual acuity was 1.0 in both eyes without corr... | a 44-year - old man presented with a history of chronic epiphora , discharge from the right eye , and a palpable mass in the medial canthal area .
irrigation of the lacrimal system revealed bloody discharge .
orbital magnetic resonance imaging ( mri ) showed a well - defined heterogeneous enhanced mass filling the ... |
noncarious cervical lesions ( nccls ) are becoming an increasingly important factor when considering the long - term health of the dentition .
in fact , the occurrence of this condition is steadily increasing [ 14 ] . according to the present literature available ,
it is not possible to determine a unique etiologic... | at this time , restoration of noncarious cervical lesions ( nccls ) is a common occurrence in clinics nowadays .
some reasons for this are the growth of the elderly population , a smaller rate of tooth loss , and possibly the increase of some etiologic factors .
these factors include inadequate brushing techniques ... |
most signaling pathways include protein kinases and their substrates that serve as means to amplify signals from extracellular signals and other stimuli .
however , the precise connectivity between protein kinases and their downstream substrates has not been fully elucidated for most protein kinases .
c - src is a ... | c - src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors , integrins and g protein - coupled receptors . we used stable isotope labeling with amino acids in cell culture ( silac ) approach to identify additional substrates of c - src tyrosine kinase in human embryonic k... |
worsening chronic heart failure ( chf ) is largely characterised by disabling symptoms , poor quality of life , frequent hospital admissions and need of specialist care .
in a pilot study evaluate home care ( hc ) versus conventional care ( cc ) in relation to medical safety , health - related quality of life ( hrql ... | backgroundworsening chronic heart failure ( chf ) is largely characterised by disabling symptoms , poor quality of life , frequent hospital admissions and need of specialist care .
lack of alternative care results in involuntary hospitalisation.aimin a pilot study evaluate home care ( hc ) versus conventional care ( ... |
diabetes mellitus is a universal health problem and may occur at any age . the traditional biochemical measurements for initially detecting patients with diabetes mellitus are random estimations of blood and urine glucose concentration .
despite their common use , both tests are nonspecific , being influenced by a wi... | to evaluate the clinical values of serum fructosamine and hbalc , serum fructosamine and hbalc were assessed in 50 normal controls and 36 patients with niddm ( non - insulin - dependent diabetes mellitus ) .
and we studied 10 patients selected at random among the 36 patients with niddm.the values of serum fructosamin... |
ocular nocardia infections are usually considered refractory to conventional topical antibiotics , resulting in a protracted clinical course and progressive extension of the disease .
if proper therapy is initiated , nocardia keratitis resolves with minimal scarring , with or without vascularization .
the main indi... | a patient with severe non - healing microscopically proven nocardia keratitis was treated with maximal topical amikacin followed by amniotic membrane transplantation ( amt ) 2 months later ( single - layer epithelial side - down ) .
epithelial healing was achieved , but neovascularization continued .
this case rep... |
marathon runners and other endurance athletes often compete in hot , humid environments throughout the spring , summer , and fall months . at the end of most endurance events each finisher
is provided with food , water or other recovery fluids ( carbohydrate - electrolyte solution , chocolate milk , etc . ) , and a r... | reflective blankets ( rb ) are often provided at the conclusion of endurance events , even in extreme environments .
the implications could be dangerous if increased core body temperature ( cbt ) is exacerbated by rb . to evaluate the effect of rb on cooling rate for individuals walking or sitting after intense runni... |
considerable progress has been made in increasing immunization coverage of children around the world through expanded immunization program ( epi ) of world health organization ( who ) . before the implantation of universal epi by who in 1974 , < 5% of children were vaccinated against the vaccine - preventable diseases ... | despite success in expanded program immunization for an increase in vaccination coverage in the children of world , timeliness and schedule of vaccination remains as one of the challenges in public health .
this study purposed to demonstrate the related factors of delayed diphtheria - tetanus - pertussis ( dtp ) vacc... |
profound vascular functional and structural changes occur in many disease states , and emerging evidence suggests that oxidative stress has a major role in mediating these changes .
for example , increased oxidative stress has been shown in hypertension - induced vascular diseases , stroke and subcortical vascular de... | oxidative stress is involved in many hypertension - related vascular diseases in the brain , including stroke and dementia .
thus , we examined the role of genetic deficiency of nadph oxidase subunit nox2 in the function and structure of cerebral arterioles during hypertension .
arterial pressure was increased in r... |
small bowel obstruction is a common clinical problem resulting from congenital [ 13 ] or acquired causes [ 47 ] .
small intestinal mechanical obstruction can be reproduced in laboratory animals using rings of different materials .
proximal to the partial obstruction site , the intestinal segment remodels morphologi... | this study was to generate phasic and tonic stress - strain curves for evaluation of smooth muscle function in the obstructed guinea pig jejunum .
partial and sham obstruction of the jejunum in guinea pigs was created surgically , with guinea pigs not being operated on served as normal controls .
the animals surviv... |
in europe the breeding of sheep and goats is a marginal agricultural activity ( 3.6% of the total value of livestock production ) but , in some countries such as uk , ireland , spain , romania and italy , the production of sheep milk and goat milk has been growing since 1995 by about 10% ( and international , 2011 ) . ... | the aim of this work was to study the microbiological and physico - chemical changes throughout three cheesemaking replicates of italian formaggelle di capra cheese made from raw goat milk .
therefore , during the process , three samples of milk , curd and cheese at 3 , 7 , 11 , 14 , 21 and 30 days of ripening old ch... |
modern drug discovery
programs typically begin with a screening
campaign ( e.g. , biochemical , virtual , or biophysical ) for agonists ,
antagonists , or inhibitors of a nominated target associated with a
particular disease . after hit identification ,
the generation of high - affinity ligands ( so - called ... | novel
pyrazolopyrimidines displaying high potency and selectivity
toward src family kinases have been developed by combining ligand - based
design and phenotypic screening in an iterative manner .
compounds
were derived from the promiscuous kinase inhibitor pp1 to search for
analogs that could potentially t... |
lipomatous hypertrophy of the interatrial septum ( lhis ) is an exaggerated growth of normal fat existing within the septum and is not a true tumor
. the septal hypertrophy may be as much as 2 cm in thickness and is seen primarily in older patients and in those who are obese .
it has been suggested that this disord... | a case of a 70-year - old female with a history of hypertension , atrial fibrillation , pacer implantation for symptomatic bradycardia , and a prior cerebrovascular accident , and had developed persistent methicillin - sensitive staphylococcus aureus bacteremia is reported here . as part of her evaluation ,
a transes... |
the data related with bombay duck and beltfish muscle trancriptomes are deposited to ncbi sra database with accession number of srx1706379 and srx1674471 , respectively .
calcium ( ca ) is the major element in the body and involved in a number of cellular events , including cell motility , transmission of nerve impul... | the contraction and relaxation events of the muscle is mediated by the coordination of many important calcium cycling proteins of ryanodine receptor ( ryr ) , troponin c ( tnnc ) , parvalbumin ( pvalb ) , sarcoendoplasmic reticulum calcium transport atpase ( serca ) and calsequestrin ( casq ) . in higher vertebrates , ... |
the utility of clickers and peer discussion in large - lecture introductory biology courses is well established .
typically , instructors pose multiple - choice questions requiring application of a recently presented concept at several points during a class . in one
commonly used approach called peer instruction , ... | although the use of clickers and peer discussion is becoming common in large - lecture undergraduate biology courses , their use is limited in small - enrollment seminar - style courses . to investigate whether facilitating peer discussion with clickers would add value to a small - enrollment seminar - style course , w... |
the world over bladder cancer is the seventh most common malignancy in men and the eighth most common malignancy in females . in india bladder cancer is the fifth most common cancer in men according to the delhi - based registry with age - adjusted incidence rate of 5.8/100,000 person years . in india
it is predomina... | aims : detrusor muscle in initial transurethral resection of the bladder tumor ( turbt ) may not be found in up to 50% of the cases .
this study was done to assess the safety , feasibility and yield of detrusor muscle on en- bloc turbt using a conventional electrocautery loop.materials and methods : patients with bla... |
the world health organization ( who ) estimates that in the developing countries one woman dies every eight minutes due to unsafe abortions .
these clandestine abortions are among the five leading causes of maternal mortality . in the developing world , an estimated five million women who undergo unsafe abortions req... | background : unsafe abortion is a major public health problem in developing countries , where women make several unsafe attempts at termination of the unintended pregnancy before turning to health services .
community health workers can act as a bridge between the community and their health facilities and can use eme... |
they have traditionally been considered benign , but recent evidence indicates that frequent apbs are a strong predictor of atrial fibrillation development and may be associated with increased risk of cardiovascular death in general population . in addition , frequent apbs may cause cardiomyopathy .
her heart was str... | a 59-year - old female with structurally normal heart was admitted to our hospital for treatment of highly symptomatic , drug refractory atrial premature beats ( apb ) .
ecg revealed atrial parasystolic trigeminy .
the arrhythmogenic focus was mapped and ablated using magnetic remote navigation and 3d electroanatom... |
the incidences of neuropsychiatric manifestations , like affective disorder or depression , are increasingly reported in general psychiatric and neurological practices , due to high - stress lifestyle .
there are many contributing psychological , neuropsychiatric , and medical factors that should be investigated .
... | the antiphospholipid syndrome ( aps ) is a rare form of autoimmune coagulopathy . in this syndrome ,
the most common neurologic abnormality is transient ischemic attack .
this can be easily overlooked if a patient presents with progressive neuropsychiatric disorders , such as depression or dementia .
we report tw... |
one major concern of endodontists is to prevent microleakage after root canal filling , in order to prevent bacterial invasion to the root canal space .
that is because microorganisms play a significant role in pulpal and periapical diseases [ 1 , 2 ] .
reported that in coronally unsealed endodontically treated tee... | objectives : the aim of this study was to compare apical sealing ability of alpha and beta phases of gutta - percha by means of bacterial leakage model.materials and methods : fifty single - rooted human premolars were selected .
the root canals were prepared with mtwo rotary instruments up to apical # 35.04 .
fort... |
in this review we consider the problem of detection of deterministic gravitational - wave signals in the noise of a detector and the question of estimation of their parameters .
the examples of deterministic signals are gravitational waves from rotating neutron stars , coalescing compact binaries , and supernova expl... | the article reviews the statistical theory of signal detection in application to analysis of deterministic gravitational - wave signals in the noise of a detector .
statistical foundations for the theory of signal detection and parameter estimation are presented .
several tools needed for both theoretical evaluatio... |
the purpose of this study was to assess predictability , efficacy , safety and stability in patients who received a toric implantable collamer lens to correct moderate to high myopic astigmatism .
forty - three eyes of 23 patients underwent implantation of a toric implantable collamer lens ( staar surgical inc ) for ... | purpose : the purpose of this study was to assess predictability , efficacy , safety and stability in patients who received a toric implantable collamer lens to correct moderate to high myopic astigmatism.methods:forty-three eyes of 23 patients underwent implantation of a toric implantable collamer lens ( staar surgica... |
social networking sites ( snss ) are found to be growing in popularity for various types of usages . amongst the internet users , one - third use snss and 10% of the total time spent online
just as any other means of communication , snss allow its users to meet others , both familiar and non - familiar ones .
it he... | background : social networking is seen as a way to enhance social support and feeling of well - being .
the present work explores the potentials of social networking sites as an adjunctive treatment modality for initiating treatment contact as well as for managing psychological problems.materials and methods : interv... |
secondary metabolites have long served as inspirational structural and functional scaffolds for the development of new - in - class pharmaceuticals [ 1 - 2 ] .
a longstanding era of secondary metabolite discovery followed the discovery of penicillin in the 1920s , and by the 1990s , approximately 80% of commercial dr... | the connection of microbial biosynthetic gene clusters to the small molecule metabolites they encode is central to the discovery and characterization of new metabolic pathways with ecological and pharmacological potential . with increasing microbial genome sequence information being deposited into publicly available da... |
adult intussusception ( ai ) in the western countries is usually caused by tumors and requires resection .
( 1 ) in africa and other tropical locations , ai is frequently due to other causes . ( 210 ) .
the purpose of this case report of ai , encountered by the authors ( rsg and alk ) during a surgical mission to t... | adult intussusception is a relatively infrequent , but well documented entity in the western surgical literature , where the majorities of cases is caused by tumors and require resection .
in africa and other tropical locations , however , other causes of adult intussusceptions predominate and must be considered . as... |
necrotic tissues , bacteria , and biofilms have been identified , along with coronal leakage , vis - a - vis poor restorations , recurrent caries , tooth fractures , or extensive periodontal disease , as the causes for persistent periapical disease following root canal treatment .
elimination of these etiologies is e... | the aim of this study was to compare the cleanliness of root canal walls after retreatment using two rotary retreatment files to hand instruments in severely curved canals obturated with gutta - percha and two different sealers .
single rooted mandibular premolars ( n = 90 ) with root curvatures were instrumented and... |
motor unit number estimation ( mune ) was originally described by mccomas et al . over three decades ago .
the original technique was a modification of the compound muscle action potential ( cmap ) recording technique that employed a gradual increase of stimulation to obtain submaximal increments .
these increments... | compound muscle action potential ( cmap ) and motor unit number estimation ( mune ) are electrophysiological techniques that can be used to monitor the functional status of a motor unit pool in vivo
. these measures can provide insight into the normal development and degeneration of the neuromuscular system .
these... |
we used the data collected at the baseline visit for the renal insufficiency and cardiovascular events ( riace ) italian multicenter study ( registered with clinicaltrials.gov , nct00715481 ; http://clinicaltrials.gov/ct2/show/nct00715481 ) , an observational , prospective cohort study on the effect of egfr on cvd morb... | objectivealthough a reduced estimated glomerular filtration rate ( egfr ) was shown to be a powerful independent predictor of cardiovascular disease ( cvd ) , other studies suggested that it confers a much lower risk than albuminuria alone , whereas the combination of the two abnormalities is associated with multiplica... |
recently , authors have
argued that prevention is the most effective
strategy for protecting native biodiversity and avoiding unwanted
economic damages from invasive species .
further , prevention
focused on dispersal pathways ( e.g. , waterway connections , canals ,
ships ballast , organisms in trade ) is ... | recently ,
authors have theorized that invasive species prevention
is more cost - effective than control in protecting ecosystem services .
however , quantification of the effectiveness of prevention is rare
because experiments at field scales are expensive or infeasible .
we
therefore used structured exper... |
the term manual lymph drainage ( mld ) was coined by the vodders during their years of
developing many of the techniques in use today .
the vodder technique of mld is the most
widely practiced method in asia , europe , north america , and countries in other areas of the
world1 , 2 .
mld is widely employed for... | [ purpose ] the present study investigated the effect of manual lymph drainage ( mld ) of
the neck on electroencephalography ( eeg ) in subjects with psychological stress .
[ methods ]
twenty - six subjects were randomly allocated to receive one 15-min session of either mld or
resting on a bed ( control ) .
[... |
conventional hormonal replacement therapy with estrogen and estrogen - progesterone found a place in the management of menopause .
clear - cut follow - up schedules are in place for conventional hormone replacement therapy . with passage of time
we have more therapies in the basket , for example , a widely acting g... | objectives : the present retrospective study was undertaken to assess safety profile of long term tibolone therapy when one of my patients developed carcinoma breast.methods:fifty patients who were put on tibolone were studied as regards the indication for tibolone therapy , age distribution , duration of therapy and s... |
accessory and ectopic liver lobes have a low incidence and are usually identified during imaging studies or autopsy .
they are classified as accessory liver lobes when connected to the liver by a stalk and as ectopic liver tissue when there is no connection .
reports of ectopic liver are rare although this entity h... | the differential diagnosis of perigastric masses is broad , ranging from benign to malignant entities . among the benign entities , accessory liver lobes and ectopic liver
are unusual and often incidentally discovered . here
, we report a patient with malignant melanoma who was clinically suspected to have a periga... |
in type i diabetes , the insulin - producing islets of langerhans , scattered throughout the pancreas , are selectively destroyed by an apparent autoimmune process .
daily and often multiple injections of exogenous human recombinant insulin are the current standard of care . despite continual advances in insulin ther... | we have previously described the use of a double coated agarose - agarose porcine islet macrobead for the treatment of type i diabetes mellitus . in the current study ,
the long - term viral safety of macrobead implantation into pancreatectomized diabetic dogs treated with pravastatin ( n = 3 ) was assessed while 2 d... |
it is estimated that about 30 to 100 million people in endemic areas of the world are infected , especially in tropical and subtropical countries ( 1 ) .
it has variable manifestations from asymptomatic to hyperinfection , or disseminated infection ( 2 ) .
most cases are completely asymptomatic ; some patients have... | backgroundclinical manifestations of strongyloides stercoralis are variable from asymptomatic to hyperinfection and devastating disseminated infections .
hereby , clinical characteristics of a large series of iranian strongyloidiasis indigenous cases are described.methodsthe records of people referred to the helminth... |
cartilaginous tumors of larynx are very rare . primary chondroid tumors of larynx are less than 1% of all laryngeal tumors [ 13 ] .
7075% of these tumors detect on endolaryngeal part of cricoid cartilage [ 13 , 6 ] .
male : female ratio is 1 : 4 [ 711 ] .
although there is no definitive etiologic factor for t... | primary chondroid tumors of the larynx represent less than 1% of all laryngeal tumors .
most of them are chondromas and they often involve to the cricoid cartilage .
a 31-year - old male patient applied to the oto - laryngology service with a history of dysphonia and dyspnea .
microlaryngoscopy revealed 2 cm siz... |
the human -herpesviruses , including cytomegalovirus ( cmv ) and human herpesvirus 6 ( hhv-6 ) , are ubiquitous among human populations.1 in brazil , serological prevalence surveys conducted in the north and southeast regions show adult infections rates for hhv-6 and cmv of around 90% among the population studied ( 0 -... | objective : the aim of this study was to simultaneously monitoring cytomegalovirus and human herpesvirus 6 active infections using nested - polymerase chain reaction and , together with clinical findings , follow the clinical status of patients undergoing liver transplant.introduction:the human -herpesviruses , includi... |
brain drain is defined as the movement of health personnel in search of the better standard of living and life quality , higher salaries , access to advanced technology and more stable political conditions in different places worldwide .
brain drain may be within countries ( internal brain drain ) , but in most cases... | migration of health workers
brain drain is defined as the movement of health personnel in search of a better standard of living and life quality , higher salaries , access to advanced technology and more stable political conditions in different places worldwide .
the debate about migration of health workers from th... |
hundred married females from an urban area of pune city were taken for this study by random sampling . after due consent , each participant was subjected to psychosocial performa designed for this study ( pretested and validated ) , personal attribute questionnaire ( a 24-paired - item scale , each pair describing cont... | background : in our society , adherence to feminine traits by the female gender had been culturally promoted and socially desired . a few studies , however , entertained the possibility that healthy men and women have some common attributes in their gender orientation .
androgyny and masculinity were found related to... |
the discrimination of tissue types , densities , and volumes from 2d and 3d images is of particular interest in the medical imaging research community .
the post - processing of 3d ct images via colorization of these morphologies holds particular utility with regards to the segmentation of skeletal muscle .
specifi... | medical imaging is of particular interest in the field of translational myology , as extant literature describes the utilization of a wide variety of techniques to non - invasively recapitulate and quantity various internal and external tissue morphologies . in the clinical context
, medical imaging remains a vital t... |
the southern community cohort study ( sccs ) is a prospective cohort study designed to identify causes of health disparities between african americans and whites in the incidence and mortality rates of several cancers and other chronic diseases ( 13 ) .
the study was approved by the institutional review boards at van... | objectiveindividuals with diabetes are at higher risk for depression than the general population . although depression can be treated with antidepressant medications , patients with diabetes and comorbid depression often go untreated .
the goal of this study was to examine racial disparities in the treatment of depre... |
periodontitis , a chronic inflammatory disease of the periodontium results in progressive loss of connective tissue attachment and supporting alveolar bone .
in addition to reducing the bone height , it alters the morphologic features of bone leading to an array of osseous defects or deformities . such periodontal bo... | aim : the aim of the present study was to evaluate the efficacy of a bovine derived xenograft bio - oss and to compare with open flap debridement in human infrabony periodontal defects.materials and methods : twelve healthy patients ( 5 males , 7 females ; aged 30 - 50 years ) , with no systemic disease with moderate t... |
neurological sufferings associated with hiv infection , especially those involving the central nervous system , are well known to the medical staff .
peripheral neuropathies are the most common neurological manifestations occurring in hiv - infected patients , sometime rising diagnostic or therapeutic problems to the... | purpose : the study aims at detecting risk factors for developing peripheral neuropathy in romanian hiv infected subjects .
material / methods : retrospective study ( january 1990-january 2009 ) who analyzed data from patients hospitalized in the regional center craiova .
we have compared 26 patients ( group n ) di... |
fifty - seven newly hatched male chickens ( samvirke kylling norway , ross 308 ) from the same hatching farm were used in this experiment conducted at the norwegian university of life sciences .
animal treatment and animal facilities all complied with the guide for the care and use of laboratory animals ( 15 ) .
al... | objectivethe aim of this study was to determine the biological effects of natural dietary intake of vitamin k as phylloquinone ( k1 ) and menaquinone-4 ( mk-4 ) and a control diet also containing menadione ( k3 ) on levels of k1 and total mk-4 ( menaquinone-4 ) and menaquinone-4 - 2,3-epoxide ( mk-4o ) ) in liver and p... |
acalvaria is an extremely rare congenital malformation characterized by an absence of flat bones of skull , dura mater , and associated muscles in the presence of normal cranial contents and facial bones.[13 ] although its pathogenesis is unclear it has been explained by the theory of post - neurulation defect .
it h... | acalvaria is described as a rare congenital malformation in a 1-month - old female baby who presented with classical clinical features of soft , lax skull as a result of absent skull bones and associated muscles .
acalvaria is usually a fatal anomaly and is rarely discussed in english literature .
thus , we herein ... |
intra - articular administration of hyaluronic acid ( ha ; hyaluronan ) is a widely applied treatment for osteoarthritis ( oa ) ( reviewed by simon and strand).1 although ha injection provides relief from pain , albeit transiently , its mechanism of action has not been fully clarified . in a recent recommendation on th... | hyaluronic acid ( ha ) has been widely used for viscosupplementation of diseased or aged articular joints .
however , recent investigations have revealed the active anti - inflammatory or chondroprotective effect of ha , suggesting its potential role in attenuation of joint damage .
in particular , interactions bet... |
the executives at children 's hospital colorado are well aware of the affects that caring for sick children and the pressure associated with it have on our entire staff .
understanding what compassion fatigue looks like as well as the importance of stress management and its role in overall wellness for each of our em... | background : healthcare is a stressful profession .
the executives at children 's hospital colorado are well aware of the affects that caring for sick children and the pressure associated with it have on our entire staff .
understanding what compassion fatigue looks like as well as the importance of stress manageme... |
low temperature is a critical environmental factor that affects growth and survival of many plant species and limits their geographical distribution .
overwintering plants are able to increase their freezing tolerance when exposed to low but non - freezing temperatures , a process known as cold acclimation . during c... | the cold shock domain ( csd ) is a nucleic acid binding domain that is widely conserved from bacteria to higher plants and animals . in escherichia coli , cold shock proteins ( csps )
are composed solely of a csd and function as rna chaperones that destabilize rna secondary structures .
cellular rnas tend to be fol... |
it has great tensile strength , and is the main component of ligaments and tendons .
it is responsible for skin elasticity , and its degradation leads to wrinkles that accompany aging .
the native tropocollagen molecule ( molecular mass 300 kda ) consists of three polypeptide chains of about 1000 amino acid residu... | differential scanning calorimetry ( dsc ) has been used to estimate the effect of disc disease on the collagen helix - coil transition and morphology for tissue extracted from patients during surgical operation .
forty discs were obtained from patients with degenerative disc disease undergoing surgery for low back ... |
open pyeloplasty remains the gold standard for correcting ureteropelvic junction obstruction with a success rate between 90% to 98% .
although endopyelotomy and retrograde dilation are alternative methods of managing ureteropelvic junction obstruction in children , the success of these 2 procedures is inferior to tha... | background : laparoscopic pyeloplasty is rapidly becoming an acceptable procedure for ureteropelvic junction obstruction in the pediatric population .
we present our experience with transperitoneal laparoscopic pyeloplasty for ureteropelvic junction obstruction in pelvic kidneys in pediatric patients.methods:a transp... |
clonidine , 2 agonist , has been introduced to clinical anaesthesia for its sympatholytic , sedative , anaesthetic sparing effects and haemodynamic stabilising properties.[14 ] dexmedetomidine , the pharmacologically active d - isomer of medetomidine ( 4,-[1-(2,3-dimethylphenyl)-ethyl ] imidazole is a highly specific a... | background : dexmedetomidine , an -2 adrenoreceptor agonist , is gaining popularity for its sympatholytic , sedative , anaesthetic sparing and haemodynamic stabilising properties without significant respiratory depression.methods:we assessed the efficacy of dexmedetomidine in attenuating sympathoadrenal response to tra... |
in the last decade the necessity for multicenter studies has arisen in order to increase sample sizes and therefore reliability of results .
this multicenter approach is particularly important for rare disorders , such as huntington 's disease ( hd ) , because it permits collecting data from a sufficiently large numb... | purposeassessment of the feasibility to average diffusion tensor imaging ( dti ) metrics of mri data acquired in the course of a multicenter study.materials and methodssixty - one early stage huntington 's disease patients and forty healthy controls were studied using four different mr scanners at four european sites w... |
it is defined as a transient loss of consciousness attributable to global cerebral hypo - perfusion , further characterized by rapid onset , brevity , and spontaneous recovery .
neurally - mediated syncope ( nms ) is by far the most common cause of transient loss of consciousness but diagnosis can be challenging in s... | syncope is a common disorder with a lifetime prevalence of about 40% .
implantable cardiac electronic devices , including implantable loop recorders ( ilr ) and implantable cardioverter - defibrillators ( icd ) , are well established in syncope management . however , despite the successful use of ilr and icd , diagno... |
basosquamous carcinoma ( bsc ) is a rare epithelial neoplasm with features of both basal cell carcinoma ( bcc ) and squamous cell carcinoma ( scc ) and is linked by a transition area . like scc , bsc is more locally invasive , aggressive , and more likely to metastasize than forms of bcc .
clinically , most bscs are ... | basosquamous carcinoma ( bsc ) is a rare aggressive epithelial neoplasm with features of both basal cell carcinoma and squamous cell carcinoma , with a tendency toward local recurrence and a propensity for lymph node and distant metastases .
the aim of the present study was to report the case of a 63-year - old cauca... |
herein , we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine - needle aspiration biopsy with intravitreal hemorrhage and later neovascular glaucoma after biopsy . the diagnosis of retinoblastoma was confirmed after enucleation .
retinoblastoma should be considered in the differential d... | purpose : to report a case of adult retinoblastoma with a wrong diagnosis of melanoma.case report : herein , we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine - needle aspiration biopsy with intravitreal hemorrhage and later neovascular glaucoma after biopsy . the diagnosis of retinoblast... |
uas - dark
14 , uas - dronc , uas - dronc
16 , uas - hid and uas - p35
20 lines were as described previously . to co - express dronc and apaf-1 , we recombined uas - dronc and uas - apaf-1 onto the 3 chromosome .
these transgenes were misexpressed through en - gal4 , gmr - gal4 , arm - gal4 or tubulin > frt > y... | apoptosis is induced by caspases , which are members of the cysteine protease family 1 .
caspases are synthesized as inactive zymogens and initiator caspases first gain activity by associating with an oligomeric complex of their adaptor proteins , such as the apoptosome 2,3 .
activated initiator caspases subsequent... |
the trigeminal neuralgia is defined as sudden , usually unilateral , severe , brief , stabbing , recurrent episodes of pain in the distribution of one or more branches of the trigeminal nerve ( fifth cranial nerve ) . in 80 - 90% of cases ,
it is thought to be caused by compression of the trigeminal nerve by a loop o... | a 74-year - old female with trigeminal neuralgia developed hypertension after the initiation of carbamazepine therapy .
the time sequence of start of the suspected drug and onset of hypertension are consistent with the diagnosis .
the hypertension did not resolve with antihypertensive therapy or dose reduction of c... |
the incidence of unstable intertrochanteric fractures has grown substantially in the elderly along with an increasing life expectancy .
intertrochanteric fractures are more common in elderly patients and result in a high morbidity and a more difficult rehabilitation resulting from a deterioration of muscle strength a... | purposewe conducted a study on patients who underwent hip joint arthroplasty because of unstable femur intertrochanteric fractures with greater trochanter bony fragments . after dividing patients into three groups depending on their fracture patterns
, we evaluated the clinical and radiological outcomes of different ... |
although the phenomenology of coexisting obsessive compulsive disorder ( ocd ) and bipolar disorder ( bd ) has been identified for more than 100 years,1 the etiological and nosological aspects of this medical issue remain largely unknown .
symptoms of ocd may occur before , during , or after the first mood episode a... | comorbid obsessive compulsive disorder ( ocd ) and bipolar disorder ( bd ) have long been an intractable problem in clinical practice .
the increased risk of manic / hypomanic switch hinders the use of antidepressants for managing coexisting ocd symptoms in bd patients .
we herein present a case of a patient with ... |
the left atrial ( la ) calcification is a relatively uncommon complication of long - standing rheumatic valvular heart disease.1 ) completed calcification of la has been described as a ' coconut atrium'2)3 ) or ' porcelain atrium'.4)5 ) porcelain atrium involves the la appendage , the free wall of the la and the mitral... | calcification of the left atrium can be observed in patients with a long - lasting rheumatic heart disease .
however , massive calcification of the atrial wall , so called porcelain or coconut atrium is very rare and has been generally reported only as incidental radiographic findings .
we report a case of massive ... |
a lot of natural herbs distributed around the mediterranean sea have been traditionally used by local people .
most of the studies on plants to grow for mediterranean climate have been investigated mainly in tolerance for the drying and relationship with environmental stress .
however , the physiological function o... | energy metabolism is a very important process to improve and maintain health from the point of view of physiology .
it is well known that the intracellular atp production is contributed to energy metabolism in cells .
cistus monspeliensis is widely used as tea , spices , and medical herb ; however , it has not been... |
until recently , most general obstetrician - gynecologists in the united states ( us ) had little opportunity to provide care to hiv - infected women .
screening guidelines published in 2006 and 2008 [ 1 , 2 ] and advances in treatment have changed the landscape of treatment and care of hiv - infected women . as more... | objective . to compare frequencies of complications among hiv - infected and - uninfected women undergoing common gynecological surgical procedures in inpatient settings
. methods .
we used 19942007 data from the nationwide inpatient sample of the healthcare cost and utilization project , a nationally representativ... |
streptococci in man are responsible for a variety of infections , ranging from relatively mild
illnesses , such as pharyngitis and impetigo , to clinically severe pathologies
such as pneumonia , septicaemia , necrotizing fasciitis or myositis .
classically ,
arthritis secondary to group a streptococcal ( gas ) ... | a study was performed of consecutive patients presenting to a dutch
early arthritis clinic with a primary suggested diagnosis of reactive
arthritis due to streptococci between april 1998 and january 2003 , in a
well - defined reference population consisting of 600 000 inhabitants . at
1 year after presentation ... |
with rising life expectancy , the number of elderly persons in developed communities increases . according to the world factbook ,
life expectancy for those born in 2013 is 84.19 years for the japanese and 80.32 years for the german population .
diseases and injuries of the musculoskeletal system specific to the ... | fragility fractures of the pelvic ring ( ffp ) are increasing in frequency and require challenging treatment .
a new comprehensive classification considers both fracture morphology and degree of instability .
the classification system also provides recommendations for type and invasiveness of treatment . in this a... |
antibody - secreting cells were at one point divided into two categories : the plasmablast and the more mature pcs ( 7 ) .
the pc compartment has been further divided into short- and long - lived cells ( 4 , 5 , 8) , with the latter being considered more mature .
within such a simple scheme , however , precursor p... | antibodies specific for self - antigens mediate life - threatening pathology in several autoimmune diseases .
clearly the ability to target the plasma cells ( pcs ) producing the autoantibodies would be of great clinical benefit .
current immunosuppressive therapies are based on the premise that autoreactive pcs ar... |
pemphigus vulgaris ( pv ) is an uncommon ( 0.53.2 cases per 100,000 ) , potentially life - threatening ( 5%15% ) , autoimmune bullous mucocutaneous disease,1 which can rarely affect the eyes .
autoantibodies are formed against desmoglein , the glue that attaches adjacent epidermal cells . when autoantibodies attack... | we present an interesting case of pemphigus vulgaris with severe and rare eye manifestations .
an old lady with systemic and ocular manifestations of pemphigus vulgaris was treated with systemic corticosteroids and immunosuppressants , with no effect .
subconjunctival injection of triamcinolone acetate reduced the ... |
dermoid cysts are the most frequently occurring tumors among ovarian germ cell tumors , accounting for more than 20% of all ovarian neoplasms.1 they present most commonly in women younger than 20 years of age , but sometimes occur in menopausal women at a rate of about 10% to 20% .
fibrothecomas are ovarian tumors of... | the term collision tumor refers to the coexistence of two adjacent but histological distinct tumors with no histological admixture at the interface .
collision tumors involving ovaries are extremely rare .
a collision tumor composed of a dermoid cyst and fibrothecoma is extremely rare in menopausal women .
the me... |
since the discovery of helicobacter pylori ( h. pylori ) by warren and marshall in 1983 , more than 30 non - pylori - helicobacter species have been described [ 2 , 3 ] . to date ,
h. bizzozeronnii , h. canadensis , h. canis , h. cinaedi , h. fennelliae , h. felis , h. heilmannii , h. pullorum , h. rappini , h. salom... | forty strains of h. fennelliae collected from paediatric blood and stool samples over an 18 year period at a children 's hospital in cape town , south africa , were amplified by pcr of the 16s rrna .
two distinct genotypes of h. fennelliae were identified based on the phylogenetic analysis .
this was confirmed by s... |
giant inguinal hernias ( gih ) are rarely encountered in high income countries ; however , in low resource setting such conditions present more frequently often do to a lack of patient knowledge , trust in the health system , or funds to pay for treatment . additionally , in low income countries
, resources may precl... | in this report we discuss the clinical management of a giant inguinal hernia ( gih ) in sierra leone where surgical resources are severely limited . though possibly not appropriate for more heavily resourced areas , a three - stage repair proved to be effective and safe for the management of this condition.careful expl... |
pneumocystis species are eukaryotic organisms detected world - wide and infect mammalian hosts including animals and humans .
pneumocystis jiroveci causes lethal pneumocystis pneumonia ( pcp ) in immune - suppressed hosts such as patients with aids and those receiving immune suppressive treatment for malignancy treat... | backgrounddetection of pneumocystis jiroveci colonization in lungs or oral samples due to high sensitivity of pcr methods results in undue treatment of patients without any symptoms of pneumocystis pneumonia .
the aim of the present study is to demonstrate pneumocystis carinii in rats , immune suppressed by oral and ... |
protein transduction domains ( ptds ) such as hiv-1 tat , pantp43 - 58 , and polyarginine ( r9 ) are small peptides that are able to transduce a variety of peptides and proteins into several kinds of cells [ 13 ] .
however , protein transduction technology using ptds has the disadvantage of entrapping the ptd - fused... | cationic peptides termed protein transduction domains ( ptds ) have been shown to cross biological membranes efficiently .
however , proteins transduced by ptds become entrapped within the endosomal vesicles and are not delivered into organelles .
we have developed a novel protein delivery system to enhance the pro... |
a pleural loose body , which is also known as a ' pleural mouse ' , ' pleural fibrin body ' , or ' thoracolithiasis ' , is a rare benign condition .
there have been several case reports of this benign condition , in which most of the loose bodies were calcified and up to 1.5 cm in size ( 123 ) .
we report a pleural... | we present a rare case of a pleural loose body , thought to be a pedunculated pleural tumor , found incidentally in a 58-year - old female .
computed tomography showed a non - enhancing mass , which migrated along the mediastinum and paravertebral area .
thoracoscopic surgery revealed a 4 cm , soap - like mass that... |
bone scaffolds , which provide the benefit of avoiding unwanted immunological responses and eliminate the risk of acquiring infectious diseases from autografts and allografts , are widely used by orthopedic surgeons when repairing different types of bone defects .
the traditional methods of manufacturing scaffolds ma... | background : three - dimensional ( 3d ) printing technology holds great promise for treating diseases or injuries that affect human bones with enhanced performance over traditional techniques . different patterns of design can lead to various mechanical properties and biocompatibility to various degrees .
however , t... |
middle ear surgery under general anaesthesia is revolutionised with the introduction of hypotensive anaesthesia that provides a relatively bloodless field while using an operating microscope .
the primary methods to minimise blood loss during middle ear surgery included mild head elevation of 15 , and infiltration or... | background and aims : middle ear surgery requires bloodless surgical field for better operating conditions , deep level of anaesthesia and rapid emergence .
recent studies suggest that 2 agonists could provide desired surgical field , sedation and analgesia .
the present study was aimed to evaluate the clinical eff... |
the interposition of sural nerve grafts for the correction of an iatrogenic sectioning of the obturator nerve during oncologic pelvic surgeries has been rarely described in the literature ( zhang et al . , 2013 , benes , 1999 ) .
the obturator nerve is an important landmark during pelvic lymph node dissection and its... | highlightsintraoperative injury of the obturator nerve is not an infrequent complication of gynecological surgeries.this injury can occur in association with pelvic lymphadenectomy for uterine or cervical cancer.this manuscript demonstrates an alternative technique for the obturator nerve repair , when primary end to e... |
purple urine bag syndrome ( pubs ) is an uncommon condition where the urine bag and tubing of long - term catheterized patients turn purple .
first reported by barlow and dickson in 1978 it is more commonly seen in chronically catheterized women and associated with chronic constipation .
the process of purple disco... | purple urine bag syndrome occurs commonly in long - term catheterized patients causing significant stress for patients , care takers , and health care providers .
this may lead to unwarranted investigation as well as treatment when not identified early .
demographic changes in indian population with increasing geri... |
primary -cells and ins1 cells were transfected with matrix - targeted photoactivatable green fluorescent protein ( pagfpmt ) expressed under the insulin promoter and allowed to accumulate in the mitochondrial matrix for 4872 h. mitochondria were labeled with 7 nmol / l tmre ( tetramethylrhodamine - ethyl - ester - perc... | objectiveprevious studies have reported that -cell mitochondria exist as discrete organelles that exhibit heterogeneous bioenergetic capacity . to date ,
networking activity , and its role in mediating -cell mitochondrial morphology and function , remains unclear . in this article , we investigate -cell mitochondrial... |
food allergy ( fa ) is an important public health problem that affects children and adults worldwide .
fa carries the risk of severe allergic reactions and even death , but there are no curative treatments and no effective prevention methods for fa yet .
fa can only be managed by avoidance of the allergen or by tre... | food allergy is an important public health problem affecting 5% of infants and children in korea .
food allergy is defined as an immune response triggered by food proteins .
food allergy is highly associated with atopic dermatitis and is one of the most common triggers of potentially fatal anaphylaxis in the commun... |
pilomatricoma ( pmx ) also known as calcifying epithelioma of malherbe or pilomatrixoma was first described as epithelioma cutis necrotic calcification malherbe by malherbe and chenantais in 1880 as a benign , subcutaneous tumor arising from sebaceous glands .
however , the term pilomatrixoma now called pmx was p... | aim : the aim of the following study is to characterize the cytological features of pilomatricomas ( pmxs ) on fine - needle aspiration ( fna ) and correlate with the histopathological features.materials and methods : fna , histopathological and clinical diagnosis of 12 cases of pmxs were analyzed . clinical , aspirati... |
for patients with st - segment elevation myocardial infarction ( stemi ) , primary percutaneous coronary intervention ( pci ) is the preferred therapy [ 1 , 2 ] .
guidelines have been composed to suggest optimal antithrombotic and antiplatelet regimens in order to prevent new ischaemic events while balancing the risk... | backgroundthe population is ageing rapidly and the proportion of patients aged 80 years undergoing primary percutaneous coronary intervention ( pci ) is rising , but clinical trials have primarily been performed in younger patients.methodspatients undergoing primary pci between 2003 and 2008 were subdivided into 3 gr... |
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