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world health organization ( who ) guidelines for pharmacological management of cancer pain consider that opioid analgesics are an established therapy for moderate - to - severe cancer pain.1 the european association of palliative care ( eapc ) recommends the use of morphine , oxycodone ( oxy ) , and hydromorphone as fi... | backgroundworld health organization step iii opioids are required to relieve moderate - to - severe cancer pain ; constipation is one of the most frequent opioid - induced side effects .
a fixed combination , prolonged - release oxycodone / naloxone ( oxn ) , was developed with the aim of reducing opioid - related ga... |
the chronic disease management network ( cdm - net ) project developed , implemented , and evaluated a broadband - based network of health services known as the chronic disease management service ( cdms ) for managing chronic disease , using type 2 diabetes mellitus ( t2 dm ) as the test disease .
a number of electro... | background . in australia
most chronic disease management is funded by medicare australia through general practitioner management plans ( gpmps ) and team care arrangements ( tcas ) .
identified barriers may be reduced effectively using a broadband - based network known as the chronic disease management service ( c... |
the complex but extremely ordered structure of the sarcomere is the elemental force - producing machinery of striated muscles .
recent studies of sarcomere assembly [ 1 , 2 ] , protein turnover [ 1 , 3 ] , and signalling cascades [ 4 , 5 ] provide new insights into the spectrum of intermolecular interactions that sup... | the giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres .
structural details , such as widths of z- and m - lines and periodicities in the thick filaments , correlate with the substructure in the respective regions of the titin molecule .
sarcomere rest length , its ... |
cis - diamminedichloroplatinum ( cisplatin ) is one of the most potent anticancer drugs and is widely used as the front - line therapy for the treatment of tumors of head , neck , lungs , and genitourinary tract .
however , the clinical application of cisplatin is limited by its serious adverse effects , particularly... | accumulating evidence demonstrated that hydrogen sulfide ( h2s ) is highly involved in inflammation , oxidative stress , and apoptosis and contributes to the pathogenesis of kidney diseases .
however , the role of h2s in cisplatin nephrotoxicity is still debatable .
here we investigated the effect of gyy4137 , a no... |
amliorer la scurit des patients grce des normes contemporaines et dtailles pour une pratique scuritaire de lanesthsie qui augmentent , amliorent et appuient les normes semblables dj publies par divers pays et procurent une ressource aux pays qui doivent encore laborer de telles normes .
linitiative mondiale une c... | purpose to enhance patient safety through contemporaneous and comprehensive standards for a safe practice of anesthesia that augment , enhance , and support similar standards already published by various countries and that provide a resource for countries that have yet to formulate such standards.standards development ... |
spondyloarthritis ( spa ) is a group of rheumatic diseases characterized by inflammatory back
pain , peripheral oligoarthritis , enthesitis , and/or extraarticular manifestations1 . ankylosing spondylitis ( as ) and psoriatic
arthritis ( psa ) are the most frequently seen spa subtypes in rheumatology units2,3,4 .
... | [ purpose ] spondyloarthritis is a major inflammatory disease followed - up in the
rheumatology clinics , foot involvement in spodyloarthritis is common .
the functional
states of patients with spondyloarthritis are usually evaluated globally .
the aim of this
study was to assess the foot involvement - relate... |
the budding yeast saccharomyces cerevisiae with its unparalleled genetic tractability has undoubtedly become the model of choice for large - scale studies on transcription , protein protein , and genetic interactions ( suter et al . , 2006 ) . nevertheless , we are far from understanding biochemistry of all yeast gene... | large - scale chemical genetics screens ( chemogenomics ) in yeast have been widely used to find drug targets , understand the mechanism - of - action of compounds , and unravel the biochemistry of drug resistance .
chemogenomics is based on the comparison of growth of gene deletants in the presence and absence of a ... |
inorganic hollow spheres of nanometer to micrometer dimensions represent an important class of materials , and are attended for wide potential applications , such as catalysts , fillers , coatings , and lightweight structural materials owing to their low density , large specific area , and surface permeability [ 2 - 5 ... | the preparation of luminescent silver hollow spheres using eu(iii ) compound based on trifluorothenoyl - acetone is described .
the structure and size of silver hollow spheres were determined by tem images .
the result shows the formation of hollow structure and average size of the silver hollow spheres ( 0.9 m ) .... |
abstractthe bcl-2/bcl - xl inhibitor navitoclax has shown promise for the treatment of cancer but on - target toxicities have limited its utility . recently
, the generation of selective bcl-2 family inhibitors has enabled a careful dissection of bcl-2 biology , and early work indicates that these molecules have impr... | |
when people originally from a lower altitude descend to sea level or lower altitude after high - altitude / hypoxia acclimatization , then they lose hypoxia tolerance and physiological adjustments .
in addition , they experience changes in hemoglobin and hormone levels over time , and this is known as high - altitude... | high - altitude deacclimatization syndrome ( hadas ) is emerging as a severe public health issue that threatens the quality of life of individuals who return to lower altitude from high altitude . in this study , we measured serum levels of sod , mda , il-17a , il-10 , tnf- , and hadas score in hadas subjects at baseli... |
new electronic devices and equipment lead to increased convenience in our lives . however , there is concern about possible hazards of the electromagnetic fields that these devices and equipment produce and their effects on human health .
electromagnetic fields have the properties of both electric and magnetic fields... | abstractthe development of new medical electronic devices and equipment has increased the use of electrical apparatuses in surgery .
many studies have reported the association of long - term exposure to extremely low - frequency magnetic fields ( elf - mfs ) with diseases or cancer .
robotic surgery has emerged as ... |
obstructive sleep apnea ( osa ) is a major public health issue characterized by repetitive episodes of partial or total occlusion of the upper airway during sleep , causing exaggerated effort to breathe against the occluded airway , sleep fragmentation , and intermittent hypoxia.1 the effects of osa during sleep ( espe... | obstructive sleep apnea ( osa ) is an extremely common comorbid condition in patients with hypertension , with a prevalence of ~50% .
there is growing evidence suggesting that osa is a secondary cause of hypertension , associated with both poor blood pressure ( bp ) control and target organ damage in patients with hy... |
the auricle , which is the part of the ear exposed to the outside , is important both functionally and esthetically.1 - 3 ) the skin of the auricle has little subcutaneous tissue , with the anterior surface having less subcutaneous tissue than the posterior surface , as well as being closely attached to the cartilage .... | background and objectivesauricular masses are growths on the outer ear that have not been well characterized clinically .
we assessed the clinical nature and treatment of auricular benign masses in patients at our institution.subjects and methodswe retrospectively identified 63 patients with auricular benign masses w... |
reported complications after pbt are radiation - induced cataract and raised intraocular pressure ( iop ) . filtering glaucoma surgery has generally been avoided because of fears of seeding .
a 37-year - old man presented with a self - discovered , pigmented lesion on his right iris .
four years later , the pigment... | background : proton beam therapy ( pbt ) is effective in the treatment of iris melanoma . reported complications after pbt are radiation - induced cataract and raised intraocular pressure ( iop ) . filtering glaucoma surgery has generally been avoided because of fears of seeding.case report : a 37-year - old man presen... |
bacterial strains : in this study , we used 67 l.
monocytogenes strains [ 15 , 31 , 34 , 35 ] .
these strains were isolated from skin of beef cattle
from a japanese farm ( five strains ) , japanese patients with listeriosis ( seven strains ) and
meat produced in japan ( 37 strains ) or imported to japan from ot... | pulse field gel electrophoresis ( pfge ) is widely used for listeriosis surveillance .
although this technique is effective for epidemiology , the data among laboratories are
inconsistent .
we previously reported a method for listeria monocytogenes
subtyping combined with sequence analysis of partial iap and wh... |
patients in the intensive care unit ( icu ) often have several organ abnormalities and physiological disarrangements that require highly complex and timely diagnostic tests and therapies.1 the first few hours after icu admission , where a patient s condition is stabilized and treatment plans are formulated , are crucia... | backgroundthe first few hours after intensive care unit ( icu ) admission , where a patient s condition is stabilized and treatment plans are formulated , are crucial to patient outcome .
although admission of patients who are unstable to icu occurs 24 hours a day , not all units maintain the same level of staffing d... |
cardiac stress testing is the basic screening tool for ischemic coronary artery disease ( cad ) . in the event of abnormal distribution of myocardial blood flow ( or positive result
indicative of functionally significant ischemia ) , coronary angiography is performed as the current gold standard in the diagnosis of i... | background : patients presenting with chest pain and evidence of functional ischemia by myocardial perfusion imaging ( mpi ) , but lacking commensurate angiographic disease pose a diagnostic and therapeutic dilemma .
they are often dismissed as having false - positive mpi. moreover , a majority of the available long... |
dental erosion is a common problem in modern societies , owing to the increased
consumption of acidic drinks , such as soft drinks , sport drinks , fruit juices , and fruit
teas , which in turn have a high potential to provoke dental demineralization . up to now
, most clinical reports are
generally related wit... | objectivethis study aimed to assess the impact of in vitro erosion
provoked by different cola - based drinks ( coke types ) , associated or not with
toothbrushing , to bonding to enamel.material and methodsfifty - six bovine enamel specimens were prepared and randomly assigned into seven
groups ( n=8 ) : c- contr... |
laryngotracheal separation ( lts ) is the most immediately life - threatening airway injury caused by any of various injuries to the neck including automobile accidents , attempted hanging , and direct blows to the anterior neck [ 1 , 2 ] .
because lts is very so rare , emergency physicians and otolaryngologists have... | laryngotracheal separation ( lts ) is the most immediately life - threatening airway injury .
lts is so rare that very few otolaryngologists have experience with it .
lts is one of the diagnostic and therapeutic challenges in airway diseases and its management remains to be established .
we experienced a patient ... |
klippel trenaunay syndrome ( kts ) is a rare congenital malformation first described in 1900 by maurice klippel and paul trenaunay .
kts is characterized by the triad of capillary malformations , atypical venous malformations and varicosities , and bony and/or soft tissue hypertrophy .
kts is estimated to affect 1... | klippel trenaunay syndrome ( kts ) is a rare congenital disorder characterized by the triad of capillary malformations , atypical venous malformations and varicosities and bony and/or soft tissue hypertrophy .
we present the case of an 18-year - old man with kts affected by haematochezia secondary to rectal venous m... |
transition / transversion ( ts : tv ) biases observed in genome comparisons are potentially the result of mutational and/or selective evolutionary processes that influence the alteration of the two fundamental types of nitrogenous bases ( i.e. , purines and pyrimidines ) that comprise dna .
it has long been observed ... | one prominent pattern of mutational frequency , long appreciated in comparative genomics , is the bias of purine / pyrimidine conserving substitutions ( transitions ) over purine / pyrimidine altering substitutions ( transversions ) .
traditionally , this transitional bias has been thought to be driven by the underly... |
the increasing availability of the prostate - specific antigen ( psa ) screening test has led to earlier diagnosis of prostate cancer as well as to the promotion of more active treatment .
radical prostatectomy is one of the most common surgical methods for radical treatment of localized prostate cancer .
laparosco... | purposeto investigate the learning curve and outcomes of robot - assisted laparoscopic radical prostatectomy ( ralp ) performed by a relatively lower volume surgeon at a secondary training hospital.materials and methodsthe medical records and the surgery video recordings of 100 patients who underwent ralp by a single s... |
since the
discovery of a three - coordinate terminal nickel imido , ( dtbpe)ni = nar
( dtbpe = bu2pch2ch2pbu2 , ar =
2,6-pr2c6h3 , scheme 1a ) in 2001 , this class of complexes remains relatively scarce , and
their reactivity remains underexplored .
the low coordination geometry offered by the strong -donatin... | the
three - coordinate imidos ( dtbpe)ni = nr ( dtbpe = tbu2pch2ch2ptbu2 , r = 2,6-ipr2c6h3 , 2,4,6-me3c6h2 ( mes ) , and 1-adamantyl ( ad ) ) , which contain
a legitimate ni
n double bond as well as basic imido nitrogen
based on theoretical analysis , readily deprotonate hccph to
form the amide acetylide spe... |
it represents about 7% of all soft tissue sarcomas and when it affects the skin , this tumor may be subdivided into two main categories : primary and secondary .
primary cutaneous leiomyosarcoma ( pcl ) of the skin is a rare soft tissue tumor that accounts for about 23% of all superficial soft tissue sarcomas .
a 7... | primary cutaneous leiomyosarcoma of the skin is a rare soft tissue neoplasm , accounting for about 23% of all superficial soft tissue sarcomas .
it arises between the ages of 50 and 70 years , and shows a greater predilection for the lower extremities .
clinically , it presents with solitary , well - circumscribed ... |
although it is a relatively new modality ,
magnetic resonance imaging ( mri ) has emerged as a prominent noninvasive
and nonradioactive imaging tool in diagnostic medicine and biomedical
research . in general , the mri signal intensity ( si ) is a function of the water proton density
of tissues under examinatio... | a simple one - step method for preparing
biocompatible nanoparticles of gadolinium ferrocyanide coordination
polymer kgd(h2o)2[fe(cn)6]h2o is reported .
the crystal structure of this coordination
polymer is determined by x - ray powder diffraction using the bulk materials .
the stability , cytotoxicity , cell... |
status epilepticus ( se ) is an emergency neurological condition defined as a continuous seizure of more than 5 minutes.1 its prevalence varies between 10 and 41 cases per 100,000 population outside of thailand.2 in thailand , se occurred in 5.10 cases per 100,000 population with a mortality rate of 0.6 per 100,000 pop... | backgroundstatus epilepticus ( se ) is a serious neurological condition and has high a mortality rate .
data on importance of factors associated with poor outcomes in asian or thai populations are limited.methodsadult patients diagnosed as se at khon kaen hospital , thailand from october 1 , 2010 to september 30 , 20... |
severe cough or hyperventilation can increase the thoracic pressure , leading to an abrupt increase in alveolar pressure and consequent rupture of alveoli .
subsequently , the air that leaks out may reach the mediastinum via the pulmonary hilum and bronchovascular interstitium . therefore , pneumomediastinum is a pat... | we report a case involving an 83-year - old man with interstitial lung disease who developed atypical pneumomediastinum caused by gas replacement of diminished fat .
the patient presented with a complaint of worsening symptoms of respiratory difficulty since a diagnosis of chronic eosinophilic pneumonia 5 months back... |
thrombotic microangiopathy ( tma ) encompasses a spectrum of diseases characterized by microangiopathic hemolytic anemia , thrombocytopenia and acute renal failure .
various treatment options have been tried for this condition , with varying degrees of treatment response . here
, we describe a case of gemcitabine -... | gemcitabine is a potent and widely used anticancer drug .
we report a case of gemcitabine - induced thrombotic microangiopathy ( gci - tma ) , a known but not widely recognized complication of gemcitabine use , and our experience of treating gci - tma with rituximab .
a 74-year - old woman was referred to our clini... |
resonance raman ( rr ) spectroscopy has long been applied to monitoring the molecular dynamics of hemoglobin ( hb).[13 ] this highly symmetric and chromophoric heme prosthetic group provides strong resonance enhancement , especially when in resonance with the intense electronic transitions centered at approximately 400... | in general , the first overtone modes produce weak bands that appear at approximately twice the wavenumber value of the fundamental transitions in vibrational spectra . here , we report the existence of a series of enhanced non - fundamental bands in resonance raman ( rr ) spectra recorded for hemoglobin ( hb ) inside ... |
activation of the coagulation system is an important part of the systemic inflammatory response during infection .
lipopolysaccharide ( lps ) , a complex outer membrane glycolipid of gram - negative bacteria , triggers an array of cellular activations through a variety of mechanisms involving diverse intracellular si... | during gram - negative sepsis , lipopolysaccharide ( lps ) activates toll - like receptor ( tlr ) 4 and induces complex responses of immune system and coagulation .
however , the underlying lps signalling mechanism on coagulation activation remains complex . to determine the role of the intracellular signalling facto... |
in malaria holoendemic areas , where malaria is stable and intense throughout the year , morbidity and mortality from plasmodium falciparummalaria occur primarily in children aged 624 months and decrease significantly after 24 months of age .
age - related protection from p. falciparum infection and disease in these ... | backgroundin areas of high - level , year - round malaria transmission , morbidity and mortality due to malaria decrease after the first two to three years of life .
this reduction may be related to the development of cellular immunity to specific antigens expressed in the different life - cycle stages of plasmodium ... |
in patients with mandibular retrognathism , it is difficult to establish a satisfactory esthetic profile,12 improve the respiratory function,34 and achieve stable treatment outcomes25 with orthodontic treatment alone .
surgical mandibular advancement with bilateral sagittal split osteotomy ( bsso ) or distraction ost... | we report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with le fort i osteotomy and two genioplasty procedures . at 9 years and 9 months of age ,
she was diagnosed with angle class iii malocclusion , a skeletal c... |
very recent studies in iran displayed the prevalence of the obesity , hypertension , and hypercholesterolemia are 30.9% , 23% , and 41.6% , respectively .
the statin group of drugs is widely used to treat hypercholesterolemia in patients at cvd risk .
statins inhibit the rate - limiting enzyme in cholesterol biosyn... | background : hydroxymethylglutaryl - coenzyme a reductase inhibitors ( statins ) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events .
the purpose of this study was to determine the effect of simvastatin on se... |
extensive evidence from studies employing a variety of mammalian species indicates that memory is organized in multiple brain systems that differ in terms of the type of memory they mediate ( for reviews see squire et al . , 1993 ;
packard and knowlton , 2002 ; white and mcdonald , 2002 ; squire , 2004 ) .
neurobio... | emotional arousal induced by stress and/or anxiety can exert complex effects on learning and memory processes in mammals .
recent studies have begun to link study of the influence of emotional arousal on memory with earlier research indicating that memory is organized in multiple systems in the brain that differ in t... |
mouse embryos form five pairs of mammary rudiments ( mrs ) . their formation is preceded by the formation of three wnt10b - expressing mammary streaks in the axilla , inguen , and in between forelimb and hindlimb
these streaks fuse into one continuous mammary line ( ml ) on each flank by e11.5 , on which mrs develop ... | the first mouse mutation associated with a heritable defect in embryonic mammary gland development was extratoes .
it represents a functional null - mutation of the gene encoding gli3 , which is best known as a transcription factor mediating canonical hedgehog ( hh ) signaling . here
we review the roles of hh and g... |
this article treats the rapid - equilibrium kinetics of the forward and reverse reactions of the enzyme - catalyzed a + b = p + q together and emphasizes the importance of reporting the values of the full set of equilibrium constants .
a computer is used to derive rate equations for three mechanisms and to estimate t... | this article deals with the rapid - equilibrium kinetics of the forward and reverse reactions together for the ordered and random enzyme - catalyzed a + b = p + q and emphasizes the importance of reporting the values of the full set of equilibrium constants .
equilibrium constants that are not in the rate equation ca... |
spinal cord injury ( sci ) impairs a patient 's motor , sensory , or autonomic system , and sci - related costs incurred by health care systems often burden society .
respiratory failure , cardiovascular dysfunction , thromboembolism , and autonomic dysreflexia are the common complications of sci .
furthermore , re... | abstractthe aim of this study was to elucidate the relationship between spinal cord injury ( sci ) and the risk of peripheral arterial disease ( pad ) in a cohort study with a large representative sample.the national health insurance database was used to select patients who were diagnosed from 2000 to 2010 .
patients... |
cerebral insults such as a traumatic brain injury ( tbi ) , stroke , or status epilepticus ( se ) can lead to detrimental outcomes for patients who suffer from one of these events .
all of these insults have been shown to cause acute cell death , disruption of the blood brain barrier , reduced neurological functional... | the jak2-stat3 signaling pathway has been shown to regulate the expression of genes involved in cell survival , cell proliferation , cell - cycle progression , and angiogenesis in development and after cerebral insults . until recently ,
little has been known about the effects of this pathway activation after cerebra... |
beedis ( or bidis ) are the commonest smoked form of tobacco in india . according to the global adult tobacco survey , 34.6% of adults are current tobacco users
. a greater proportion of males ( 47.9% ) use tobacco compared to females ( 20.3% ) . among females , while only 2.9% smoke any form of tobacco and 1.9% spec... | while tobacco use occurs in many forms all over the world , there is little information on cross - tobacco use .
authors report an unusual case of tobacco use in the form of chewing beedies which are normally smoked ( cross - tobacco use ) .
a 22-year - old single female , diagnosed with schizophrenia for the last ... |
cavernous hemangioma constitutes 5 - 10% of vascular malformations occurring in the entire central nervous system ( cns ) .
intraventricular location constituting 2.5 - 10.8% of cerebral cavernous hemangioma is uncommon because most of them are usually found in the parenchyme of cns4 ) .
so far , the intraventricul... | intraventricular cavernous hemangiomas are uncommon . among them , those occurred at the foramen of monro in the third ventricle may be of particular interest because of its rarity , development of hydrocephalus , being differentiated from other brain lesions .
we present a rare case of intraventricular cavernous hem... |
in south africa , integration of services policy was enacted in 1996 with the aim of increasing health service utilization by increasing the accessibility of all services at primary healthcare level .
however , the problem with the policy arises in the implementation of integrated primary healthcare as there is no ag... | introductionin south africa , integration of services policy was enacted in 1996 with the aim of increasing health service utilization by increasing the accessibility of all services at primary healthcare level .
however , the problem with the policy arises in the implementation of integrated primary healthcare as th... |
obesity increases the risk of metabolic disorders , such as high blood pressure , type 2
diabetes , and fatty liver1,2,3 .
it can also reduce
skeletal muscle mass and exert a negative effect on normal muscle function4 , 5 .
mammalian target of rapamycin ( mtor ) , a serine / threonine protein kinase regulating ... | [ purpose ] the aim of this study was to investigate the effects of regular treadmill
exercise on skeletal muscle rictor - akt and mtor - raptor - s6k1 signaling pathway in high - fat
diet - induced obese mice . [ subjects and methods ] four- week - old c57bl/6 mice were adopted
and classified into normal diet g... |
determinar si las caractersticas iniciales de los patrones individuales de la refraccin perifrica guardan relacin con los cambios subsiguientes de la refraccin , durante un periodo de un ao .
se reuni a 54 sujetos con miopa y emetropa ( edad media : 24,9 5,1 aos ; mediana : 24 aos ) con visin normal , sometindoles... | purposeto determine whether the initial characteristics of individual patterns of peripheral refraction relate to subsequent changes in refraction over a one - year period.methods54 myopic and emmetropic subjects ( mean age : 24.9 5.1 years ; median 24 years ) with normal vision were recruited and underwent conventi... |
the disrupted in schizophrenia 1 ( disc1 ) gene is a 414.3 kb gene located on chromosomal region 1q42.2 , and consists of 13 exons .
disc1 was originally identified as a candidate gene for schizophrenia in a large scottish family , in which a balanced translocation involving chromosomes 1 and 11 was strongly linked t... | the disrupted in schizophrenia 1 ( disc1 ) gene has been identified as a schizophrenia susceptibility gene based on linkage and single nucleotide polymorphism ( snp ) association studies and clinical data , suggesting that risk snps impact on hippocampal structure and function .
we hypothesized that altered expressio... |
studies have implicated active oxygen species ( aos ) in the pathogenesis of various lung diseases .
many chemical and physical agents in the environment are potent generators of aos , including ozone , hyperoxia , mineral dusts , paraquat , etc .
these agents produce aos by different mechanisms , but frequently th... | |
almost every type of animal cell has the capacity to synthesize heparan sulfate ( hs ) .
the hs polysaccharide is composed of alternating hexuronic acid and d - glucosamine units and is substituted with sulfate groups in various positions .
the sulfated saccharide domains provide numerous docking sites for protein ... | proteoglycan ( pg ) coreceptors carry heparan sulfate ( hs ) chains that mediate interactions with growth factors , morphogens , and receptors .
thus , pgs modulate fundamental processes such as cell survival , division , adhesion , migration , and differentiation .
this review summarizes recent biochemical and gen... |
this is the third international meeting dealing with major genes in small ruminants .
the first was held in armidale ( nsw , australia ) in 1980 , just after the discovery of the booroola gene by b. bindon and l. piper .
the discovery of a gene having such a large effect on ovulation rate and prolificacy in sheep w... | |
multiple myeloma ( mm ) is a clonal b - cell disorder in which malignant plasma cells ( pcs ) accumulate in the bone marrow , resulting in lytic bone lesions and excessive amounts of monoclonal proteins .
although therapeutic interventions have been developed , and the overall survival has been improved over the last... | background : multiple myeloma ( mm ) is a malignant tumor , which takes the second place in malignant blood disease .
the clinical symptoms are complicated that make more difficult to diagnose and therapy .
lots of researches focus on the proteins about mm in order to solve those problems .
we used proteomic meth... |
although infrequent ( 1% to 4% in the first year ) , infective endocarditis may occur after aortic valve replacement.13 when present , prosthetic valve endocarditis is a severe problem that is associated with considerable morbidity , especially related to peripheral embolism , perivalvular abscess , and sepsis.49 acute... | a 46-year - old man with bicuspid aortic valve and severe calcific aortic stenosis was submitted to aortic valve replacement with a stented bioprosthesis .
he developed staphylococcus epidermidis prosthetic valve endocarditis a month later , presenting in the emergency room with acute myocardial infarction .
the me... |
an 8-year - old male siberian tiger at the budapest zoological and botanical garden had episodes of coughing in october 2001 . because the coughing did not stop in 6 to 7 days , an expectorant ( bisolvon ; boehringer ingelheim vetmed gmbh .
his condition showed a temporary improvement ; however , after a few weeks , ... | we report the first case of pulmonary tuberculosis caused by mycobacterium bovis subsp .
caprae in a captive siberian tiger , an endangered feline .
the pathogen was isolated from a tracheal aspirate obtained by bronchoscopy .
this procedure provided a reliable in vivo diagnostic method in conjunction with conven... |
a 48-year - old man presented with visual dimness in his right eye , which had developed over the two weeks prior to the visit to the ophthalmology clinic . his medical , family , and social history was unremarkable .
his visual acuity ( va ) was 20/50 in the right eye ( od ) and 20/20 in the left eye ( os ) .
dila... | a 48-year - old man presented with visual dimness in the right eye that had developed 2 weeks previously .
dilated fundus examination showed few vitreous cells and numerous yellow , placoid lesions in both eyes .
his right eye had more severe serous retinal detachment involving the macula .
fluorescein angiograph... |
gastric cancer is the most prevalent malignant tumor and the second leading cause of cancer - related death in korea1 ) .
the benefit of systemic chemotherapy for treating advanced gastric cancer in the palliative setting has long been known . when compared with the best supportive care alone , combination chemothera... | gastric cancer patients with severe liver dysfunction secondary to hepatic metastases have limited treatment options .
most cytotoxic drugs have a narrow therapeutic index .
although both capecitabine and oxaliplatin have been well tolerated as single agents for patients with severe hepatic dysfunction , the combin... |
werner syndrome ( ws ) is an autosomal recessive disease that first captured wide attention due to its prominent premature aging ( or progeroid ) features .
ws is also of considerable biomedical science interest in light of the pairing of these progeroid features with constitutional genomic instability and an elevate... | the growing diversity of heritable skin diseases , a practical challenge to clinicians and dermatonosologists alike , has nonetheless served as a rich source of insight into skin biology and disease mechanisms .
i summarize below some key insights from the recent gene - driven phase of research on werner syndrome , a... |
some ectoparasites of hedgehogs such as ticks and fleas have zoonotic importance (
khaldi et al .
hedgehogs may act as reservoir hosts for some diseases for instance salmonellosis , leptospirosis and pulmonary capilloriois (
mccarthy and moore 2000 ,
riley and chomel 2005 ,
marie et al .
ticks and fleas are... | background : ixodid ticks ( acari : ixodidae ) and fleas ( siphonaptera ) are the major vectors of pathogens threatening animals and human healths .
the aim of our study was to detect the infestation rates of east hedgehogs ( erinaceus concolor ) with ticks and fleas in van province , eastern region of turkey.methods... |
india has the world 's highest burden of tuberculosis ( tb ) . in india ,
the multidrug - resistant tb ( mdr - tb ) prevalence among all patients with tb combined is estimated to be 4.1% . a crude estimate derived from these data is that 4500 6000 hiv - infected persons develop mdr - tb annually in india .
diagnos... | drug - resistant tuberculosis ( dr - tb ) has been reported in india , but has been rarely documented in children .
hiv co - infection has led to resurgence of tuberculosis ( tb ) , making treatment even more difficult due to complex drug interactions .
poly - resistant tb is rare in children , especially in hiv - ... |
at the towards other earths ii meeting held in porto portugal in 2014 september , one theme emerged that bares directly on the subject of this paper .
intrinsic stellar activity ( sa ) has become the main limiting factor for planet searches in both transit and radial velocity ( rv ) data .
sa includes stellar osci... | a new apodized keplerian ( ak ) model is proposed for the analysis of precision radial velocity ( rv ) data to model both planetary and stellar activity ( sa ) induced rv signals .
a symmetrical gaussian apodization function with unknown width and centre can distinguish planetary signals from sa signals on the basis ... |
clinicians have been asking this question for 15 years now , and the answer is still unclear .
richard troughton and mark richards published a seminal paper in the lancet in 2000 , in which they launched the hypothesis of guiding heart failure ( hf ) treatment with objective measurement of natriuretic peptides ( nps ... | over the last 15 years , the hypothesis that intensified treatment directed at reducing natriuretic peptide ( np ) concentrations may improve the outcomes of patients with heart failure ( hf ) has been scrutinized in several prospective clinical trials , with conflicting results . collectively , however , the data sugg... |
in the recent times , colon - specific technologies have utilized single or combination of the following primary approaches , with varying degrees of success : ( 1 ) ph - dependent systems , ( 2 ) time - dependent systems , ( 3 ) prodrugs , and ( 4 ) colonic microflora - activated systems [ 1 , 2 ] . among the differen... | the purpose of this study is to explore the possible applicability of sterculia urens gum as a novel carrier for colonic delivery system of a sparingly soluble drug , azathioprine .
the study involves designing a microflora triggered colon - targeted drug delivery system ( mcdds ) which consists of a central polysacc... |
recent diagnostic imaging tests such as computed tomography ( ct ) and magnetic resonance imaging ( mri ) contribute to improving the diagnosis of pancreatobiliary cancers [ 14 ] .
however , from the point of cost benefit , it is not practical to perform these tests for all patients as screening .
thus , less - inv... | background .
recent diagnostic imaging tests contribute to improving the diagnosis of pancreatobiliary cancers .
however , it is not practical to perform these tests for all patients as screening .
thus , less - invasive and simple screening tests are still required . a method to detect the igg antibody induced i... |
streptococcus canis ( sc ) is a zoonotic pathogen that is transferred primarily from companion animals such as dogs and cats to humans through both animal bites and other mechanisms , and usually infects immunocompromised rather than immunocompetent hosts .
this species has also been isolated from a variety of other ... | highlightsthis is the first reported human case of bacteremia caused by streptococcus canis having scm gene encoding m - like protein.the identity was based on similarity of its 16s rrna and detection of the specific cfg gene encoding a co-hemolysin.this isolate was confirmed to be sequence type 9.this strain did nt ha... |
idiopathic osteolysis is a heterogeneous group of rare diseases in which there is a spontaneous , aggressive and extensive bone resorption .
idiopathic osteolysis was first described in 1838 and again in 1872 by jackson ( 1 , 2 ) who reported a case of " boneless arm " . in 1955 ,
gorham and stout ( 3 ) defined a s... | a patient with a 2-year history of pain in the left arm , and decreased strengths unrelieved by non - steroidal anti - inflammatory therapy , was being referred for repeating radiography .
the radiologic examinations have demonstrated a unique pattern of non - contiguous osteolysis in the left elbow , proximal and di... |
to establish the desirable occlusion and articulation with proper inclination of teeth in deep - bite patients , orthodontic therapy alone is difficult and inefficient . therefore , orthognathic surgical procedures , which reconstruct occlusal plane by aligning teeth or correcting skeletal deformities , are preferred t... | this case report demonstrates the full - mouth rehabilitation of a 45-year - old male patient with severe deep - bite by increasing vertical dimension .
the technique of anterior maxillary osteotomy performed in the present situation has been found to be effective , requiring anterior and inferior repositioning of th... |
avaliar a contribuio da anlise molecular do gene cystic fibrosis transmembrane conductance regulator ( cftr , regulador da condutncia transmembrana na fibrose cstica ) na investigao diagnstica da fibrose cstica em pacientes com suspeita de fibrose cstica ( fc ) leve ou atpica .
os voluntrios foram submetidos avaliao... | objective : to evaluate the diagnostic contribution of molecular analysis of the cystic fibrosis transmembrane conductance regulator ( cftr ) gene in patients suspected of having mild or atypical cystic fibrosis ( cf ) .
methods : this was a cross - sectional study involving adolescents and adults aged 14 years .
... |
prostate cancer is the most frequent tumor in men , afflicting african american males to a greater degree than caucasians .
morbidity and mortality are mainly attributable to metastasis ; yet the mechanisms associated with progression are largely unknown .
localized carcinomas are readily removed surgically , but... | hs-27a human bone stromal cells , in 2d or 3d coultures , induced cellular plasticity in human prostate cancer arcape and arcapm cells in an emt model . cocultured arcape or arcapm cells with hs-27a , developed increased colony forming capacity and growth advantage , with arcape exhibiting the most significant increa... |
in a 2009 report , the american association of medical schools ( aamc ) and howard hughes medical institute ( hhmi ) articulate goals for quantitative biology teaching that can serve as a starting point . specifically , biology students should be able to
demonstrate quantitative numeracy and facility with the languag... | more than a decade has passed since the publication of bio2010 , calling for an increased emphasis on quantitative skills in the undergraduate biology curriculum . in that time , relatively few papers have been published that describe educational innovations in quantitative biology or provide evidence of their effects ... |
pleomorphic adenoma ( pa ) is the most common salivary gland tumor classified as benign epithelial tumors 1 .
various cell types can be seen in the tumor indicating a high occurrence of cell differentiation .
the results suggested that wnt is involved in cell differentiation in pa . in the present study
, we cons... | the expression of notch in 30 cases of pleomorphic adenoma was examined by immunohistochemistry . comparing the results of our study with previous literatures , from the partial ck7 expression and substantial notch expression in ductal epithelial cells as well as the notch expression in solid tumor nests
, it can be ... |
the endothelium - derived relaxing factor , recently identified as nitric oxide ( no ) or a closely related compound , has potent antiatherosclerotic properties . no released from endothelial cells works in concert with prostacyclin to inhibit platelet aggregation ; it inhibits the attachment of neutrophils to endothel... | the results of recent randomized trials to test the influence of antioxidants on coronary - event rates and prognosis in patients with coronary - artery disease were disappointing . in none of these studies did the use of vitamin e improve prognosis .
in contrast , treatment of coronary - artery disease with angioten... |
a study data set of 817 cases with available oncotype dx test results ( cases from 2004 to 2009 , from magee - womens hospital of the university of pittsburgh medical center ) was used to build the prediction models .
all cases included in the study were sent for oncotype dx testing owing to clinical requests receive... | oncotype dx is a commercial assay frequently used for making chemotherapy decisions in estrogen receptor ( er)-positive breast cancers .
the result is reported as a recurrence score ranging from 0 to 100 , divided into low - risk ( < 18 ) , intermediate - risk ( 1830 ) , and high - risk ( 31 ) categories .
our pilo... |
in this prospective quasi - randomized , doubleblinded , placebo - controlled study , a total of 146 reproductive women aged between 18 - 35 years old who were referred to outpatient clinics of shahid beheshty and al - zahra hospitals from december 2009 to february 2010 for infertility treatments , having at least two ... | background : phytoestrogens are a group of plants derived compounds with weekly estrogen effect that appear to have protective effects on metabolic and hormonal abnormalities of women with polycystic ovary syndrome ( pcos ) . so the aim of this study was to investigate the effect of soy phytoestrogens on reproductive h... |
calcium has long been recognized as an essential intracellular messenger involved in many pivotal biochemical pathways .
the biochemically relevant information attributed to this ionic species is believed to be encoded in the concentration and spatio - temporal properties of the calcium signal .
the relationship ... | differences in the calcium sensitivity of individual secretory vesicles can explain a defining feature of calcium - regulated exocytosis , a graded response to calcium .
the role of the time dependence of calcium delivery in defining the observed differences in the calcium sensitivity of sea urchin egg secretory ve... |
the prevalence of congenital anomalies of the coronary arteries ( caas ) is reported to be approximately 0.2 - 1.4% in the general population . of them ,
. it may be benign appearing as an incidental finding on routine coronary angiogram or sometimes , may be complicated with atherosclerosis and present with spectrum... | double right coronary artery ( rca ) is an extremely rare coronary artery anomaly .
we here report an atherosclerotic double rca which appeared after primary percutaneous intervention performed to treat a 34-year - old male presenting with acute inferior myocardial infarction , cardiogenic shock and complete heart bl... |
hereditary dystrophies of the retina , such as retinitis pigmentosa ( rp ) , are considerable causes of blindness in humans .
research efforts concerning these currently not treatable diseases are focused on the genetic background , the mechanisms of degeneration , and possible treatment strategies .
animal models ... | background . to evaluate the correlation between erg , oct , and microscopic findings in the rd10 mouse . methods .
c57bl/6j wild type mice and rd10 mice were compared at the age of 2 , 3 , 5 , 7 , 9 , 12 , 24 , and 48 weeks ( each age group n = 3 ) using full - field electroretinography ( erg ) , spectral domain opt... |
subjects between the ages of 30 to 49 years who received cataract surgery at st .
mary 's hospital from 1995 to 2004 ( n = 976 ) were included in this study .
patients with a history of ocular trauma , uveitis , ocular or systemic diseases other than diabetes and hypertension , congenital cataracts , and those who ... | purposeto investigate the long - term characteristics of cataracts among adults aged 30 to 49 years in korean over a span of 10 years.methodssubjects between the ages of 30 to 49 years who underwent cataract surgery at st .
mary 's hospital from 1995 to 2004 ( n = 976 ) were included .
patients with a history of oc... |
the prevalence of obesity has raised dramatically in recent years . increased adiposity , particularly , visceral fat accumulation , is closely associated with premature atherosclerosis and many metabolic alterations including insulin resistance , dyslipidemia and hypertension .. obesity is one of the most common disor... | obesity is associated with premature atherosclerosis , as well as with many metabolic alterations including insulin resistance , dyslipidemia and hypertension .
visceral fat accumulation , particularly , is closely associated with the development of metabolic syndrome .
the menopause transition , as well as the ear... |
zinc oxide ( zno ) nanoparticles represent an important class of commercially applied materials . they have been widely applied in diagnostics , therapeutics , drug - delivery systems , electronics , cosmetics , personal care products , and food additives , due to their magnetic , catalytic , semiconducting , antimicro... | biokinetic studies of zinc oxide ( zno ) nanoparticles involve systematic and quantitative analyses of absorption , distribution , metabolism , and excretion in plasma and tissues of whole animals after exposure .
a full understanding of the biokinetics provides basic information about nanoparticle entry into systemi... |
autotransplantation is the surgical transposition of a tooth from its original site to another extraction or surgically formed recipient site in the same individual .
autotransplantation is advocated in various conditions such as teeth with extensive caries , advanced periodontal diseases , congenitally missing , imp... | autotransplantation is the surgical transposition of a tooth from its original site to another , replacing a lost or a compromised tooth by another tooth , usually the third molar in the same individual .
this technique is considered a viable method due to its high success rate , well - grounded treatment option , pr... |
postoperative ileus ( poi ) is a transient impairment of normal gastrointestinal ( gi ) motility seen after major abdominal operations and periodically after nonabdominal operations , with characteristics including nausea and vomiting , bloating , abdominal pain and discomfort , absence of passage of flatus or stool , ... | postoperative ileus ( poi ) , which occurs after surgical manipulation of the bowel during abdominal operations , is associated with prolonged hospital stay , increasing medical costs , and delayed advancement of enteral diet , which contributes to a significant economic burden on the healthcare system .
the use of a... |
within the next 20 years , it is anticipated that copd will rank fifth for overall causes of disability worldwide ( murray and lopez 1996 ) .
year 2000 statistics rank copd as the fourth most common cause of death in the us ( minino and smith 2001 ) .
when considering smoking burden in the mortality rankings , copd... | the cost burden of copd is substantial for patients and families , payers , and society as a whole .
smoking has been known for decades to be the leading cause of the disease .
numerous studies have been completed to address the cost - effectiveness of programs created to aid smokers in their efforts to quit . beca... |
the accurate duplication of the genome is critical to the survival of any organism .
dna damage , such as that caused by uv irradiation , can disrupt the replication machinery and prevent it from completing its task [ 1 , 2 ] . in escherichia coli , a number of the cellular events associated with the recovery of repl... | uvrd is a dna helicase that participates in nucleotide excision repair and several replication - associated processes , including methyl - directed mismatch repair and recombination .
uvrd is capable of displacing oligonucleotides from synthetic forked dna structures in vitro and is essential for viability in the abs... |
subacute sclerosing panencephalitis ( sspe ) is a progressive inflammatory and degenerative disease of central nervous system caused by persistent infection of immune - resistant measles virus . the average period between exposure and onset of sspe ranges between 7 and 12 years .
the typical clinical course of sspe i... | we report a 14-year - old boy who presented with loss of consciousness and gait instability .
the electroencephalogram ( eeg ) showed generalized slowing with irregular activity and cerebral magnetic imaging revealed asymmetrical nonspecific signals on basal ganglia .
his second electroencephalogram revealed period... |
children s oncology group ( cog ) member institutions care for the majority of infants , children , and adolescents with acute lymphoblastic leukemia in north america and oceania .
work by the legacy children s cancer group ( ccg ) , dating back more than 40 years , serves as the foundation for many current cog trial... | the children s cancer group enrolled 13,298 young people age < 21 years on one of 16 protocols between 1983 and 2002 .
outcomes were examined in three time periods , 19831988 , 19891995 , 19962002 . over the three intervals , 10-year event - free survival ( efs ) for rome
/ nci standard risk and higher risk b - pre... |
to describe the anatomy and coronal alignment of the leg , a number of descriptive terms are used .
the anatomical axis of each bone refers to a line drawn along the centre of the intramedullary canal .
the mechanical axis of the femur refers to a line drawn from the centre of the femoral head to the centre of the ... | recent studies have challenged the long - held notion that neutral mechanical alignment after total knee arthroplasty leads to optimal function and survivorship.the ideal alignment for function and survivorship may actually be different.kinematic alignment , where components are implanted to re - create the natural fle... |
there are many reasons why researchers choose to publish the results of their research but one of the most important is to contribute to the advancement of medicine and science .
when research involves human subjects , sharing results is more than a personal choice , it is an ethical obligation ( 1 ) .
publishing r... | researchers have an ethical responsibility to report the results of research involving human subjects .
dissemination of results ensures that patient care is based on good science and that the field of medicine advances based on complete and accurate knowledge .
however , current evidence suggests that publication ... |
idiopathic thrombocytopenic purpura ( itp ) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies , which may predispose to bleeding.1 ) since severe bleeding is uncommon when the platelet count exceeds 30000... | idiopathic thrombocytopenic purpura ( itp ) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies , which may predispose to bleeding .
although the prevalence of coronary artery disease ( cad ) in itp seems... |
spirometry after bronchodilation is crucial in assessing the presence of airway obstruction , which is necessary for the diagnosis of chronic obstructive pulmonary disease ( copd).1 chronic airway obstruction is mostly assessed using the ratio of forced expiratory volume in 1 second ( fev1)/forced vital capacity ( fvc ... | backgroundspirometric diagnosis of chronic obstructive pulmonary disease ( copd ) is based on the ratio of forced expiratory volume in 1 second ( fev1)/vital capacity ( vc ) , either as a fixed value < 0.7 or below the lower limit of normal ( lln ) . forced vital capacity ( fvc ) is a proxy for vc .
the first aim was... |
it is a potent opioid analgesic with ultra - short duration of action , extremely rapid peak effect , and an equally consistent and rapid elimination with complete cessation of effect within a maximum of 10 minutes . in clinical practice
an excessive bolus dose however can cause rapid onset of potentially life - thre... | remifentanil is an opioid analgesic frequently used in intensive care patients because of its rapid onset of action , potency , and ultra - short duration .
if an excessive dose is given , it leads to rapid , short lasting , potentially life - threatening side effects such as apnea , bradycadia , hypotension , and ri... |
current rectal cancer treatment is based on a multidisciplinary approach entailing surgery , chemotherapy , and radiotherapy .
the aim of surgery is to remove the rectum and the mesorectum contained within the intact fascia of the rectum .
this technique reduces pelvic recurrence , prolongs survival , and preserves... | background : traditional laparoscopic anterior rectal resection ( tlar ) has recently been used for rectal cancer , offering good functional results compared with open anterior resection and resulting in a better postoperative early outcome . however
, laparoscopic rectal resection can be technically demanding , espe... |
patients with t2 dm and pll were identified by one of the authors ( w.t.g . ) in clinics sponsored by divisions of endocrinology or nutrition sciences at academic institutions during a 25-year period .
ten of these patients ( half of the total ) agreed to participate in metabolic studies on a research ward and consti... | objectivelipodystrophies are categorized by the extent of fat loss ( generalized vs. partial ) and by inheritance ( congenital vs. acquired ) .
we examined whether a group of patients with partial lipodystrophy of the limbs ( pll ) , type 2 diabetes mellitus ( t2 dm ) , and an absence of a family history of lipodystr... |
leptospirosis is a zoonotic infection in humans and animals caused by leptospira species of the spirochete family ( 1 ) .
the first phase occurs during the active leptospira infection named as bacteriemic or septicemic phase . in this phase ,
flu - like symptoms ( including fever , severe headache , myalgia , chill... | background : thrombocytopenia is associated with a bad prognosis in leptospirosis.objectives:we investigated the effect of corticosteroids to improve thrombocytopenia due to leptospirosis.patients and methods : in a clinical trial , all patients admitted with leptospirosis in razi hospital of ghaemshahr , north of iran... |
coupling of metal on conventional polyethylene have been traditionally used as bearing surface of total hip arthroplasty ( tha ) . however , this coupling could make debris of polyethylene resulting in an aseptic loosening over time is well known1 ) .
previous other studies reported young age and increased activity l... | purposewe evaluated the clinical and radiographic midterm results of primary total hip arthroplasty ( tha ) using a 36 mm diameter femoral head on 1st generation highly cross - linked polyethylene ( hxlpe ) in patients 50 years and less with minimum five year follow-up.materials and methodswe retrospectively reviewed 3... |
we describe three cases of submacular hemorrhage ( smh ) that occurred two to four days after anti - vascular endothelial growth factor ( anti - vegf ) intravitreal injection for occult choroidal neovascularisation ( cnv ) in age related macular degeneration1 ( amd ) and their management .
almost 2500 anti - vegf int... | we describe three cases of submacular hemorrhage that occurred two to four days after anti - vegf intravitreal injection for occult choroidal neovascularisation in age - related macular degeneration and their management with 25 gauge pars plana vitrectomy with injection of subretinal recombinant tissue plasminogen acti... |
teeth being the central component of the masticatory apparatus of the skull are good sources of material for civil and medicolegal identification .
teeth provide resistance to damage in terms of bacterial decomposition and fire when rest of body is damaged beyond recognition which makes them valuable tool in forensic... | background : sexual dimorphism refers to the differences in size , shape , etc . , between males and females .
the dentition 's use in sex assessment has been explored and advocated owing to its strength and resistance to peri- and post - mortem insults.objectives:the study evaluated permanent maxillary incisors and ... |
retrotransposons are mobile genetic elements , closely related to retroviruses , which use their own proteins in conjunction with cellular machinery to replicate independently of the genome .
the yeast retrotransposon ty3 , and retroviruses such as human immunodeficiency virus type-1 ( hiv-1 ) , encode reverse transc... | reverse transcription in retroviruses and retrotransposons requires nucleic acid chaperones , which drive the rearrangement of nucleic acid conformation .
the nucleic acid chaperone properties of the human immunodeficiency virus type-1 ( hiv-1 ) nucleocapsid ( nc ) protein have been extensively studied , and nucleic ... |
asthma is a complex and common disorder that is characterized by chronic inammation of the respiratory system , airow obstruction , and airway hyper - reactivity induced by certain stimulants , such as exercise , infection , allergens , and occupational exposures .
as one of the most prevalent chronic diseases , asth... | backgroundthe aim of this study was to examine the associations between the single - nucleotide polymorphisms ( snps ) of interleukin-17 ( il-17 ) , including rs763780 ( 7488a / g ) , rs2275913 ( 197g / a ) , and rs8193036 ( 737c / t ) , and asthma susceptibility in an asian population.material/methodsfrom oct 2013 to ... |
in the previous issue of critical care , rumpf and colleagues evaluated the potential contribution of measuring end - tidal carbon dioxide ( co2 ) for suspected pulmonary embolism ( pe ) in the prehospital setting .
capnography has been studied for decades as a potential diagnostic tool for patients with suspected ... | capnography has been studied for decades as a potential diagnostic tool for suspected pulmonary embolism . despite technological refinements and its combination with other non - invasive instruments ,
no evidence to date allows recommending the use of expired carbon dioxide measurement as a rule - out test for pulmon... |
a 20-year - old virgin patient with an episode of massive menorrhagia at menarche was admitted to the emergency room ( er ) of the department of obstetrics and gynecology .
her medical history revealed that 15 days prior to the presentation at the emergency department , she had been prescribed a ten - day course of p... | hematometrocolpos is accumulation of blood in the vagina and uterine cavity due to intra - uterine hemorrhage .
a 20-year - old female presented to our clinic with massive menorrhagia at menarche after progestin usage .
hematometrocolpos was detected by transabdominal ultrasonography .
she was pale because of hea... |
coronal plane alignment of the lower limb is an important factor that affects implant stability and clinical outcomes after total knee arthroplasty ( tka)1 - 3 ) .
varus osteoarthritis of the knee is the most common indication for tka , which is accompanied with contracture of the medial collateral ligament and other... | purposeto assess proper soft tissue balancing of the varus arthritic knee between posterior oblique ligament ( pol ) release group and superficial medial collateral ligament ( smcl ) release group.materials and methodsthis retrospective study was performed on 186 patients who underwent minimally invasive surgery ( mis ... |
despite well over 150
years of clinical use , a detailed molecular
mechanism of anesthesia remains unresolved .
the once prevailing hypothesis
suggested that anesthetics worked through a nonspecific , membrane
disruption mechanism , known as the meyer
recent studies have shown that most , if not all , anest... | while small molecules have been used
to induce anesthesia in a
clinical setting for well over a century , a detailed understanding
of the molecular mechanism remains elusive . in this study , we utilize
ab initio calculations to develop a novel set of charmm - compatible
parameters for the ubiquitous modern a... |
contrast - induced nephropathy ( cin ) was a common cause of acute kidney injury ( aki ) .
the prevalence ranged from 2% to 30% because of different studied cohorts ( underwent diagnostic or therapeutic procedures ) and cin definitions .
patients who developed aki after contrast medium exposure had markedly increas... | abstractthe aim of the study was to investigate the long - term association between contrast medium exposure during computed tomography ( ct ) and the subsequent development of end - stage renal disease ( esrd ) in patients with chronic kidney disease ( ckd).we conducted a population - based cohort study using taiwan '... |
bariatric surgery ( bibp and agb ) is routinely performed at the obesity centers of the institutions participating in this study .
patients are eligible for bariatric surgery if they meet the following criteria : 1865 years of age and a bmi > 40.0 kg / m alone or a bmi > 35.0
kg / m in the presence of comorbidities... | objectivemalabsorptive bariatric surgery ( biliopancreatic diversion and biliointestinal bypass [ bibp ] ) reduces serum cholesterol levels more than restrictive surgery ( adjustable gastric banding [ agb ] ) , and this is thought to be due to greater weight loss .
our aim was to evaluate the changes of cholesterol m... |
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