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a 72-year old woman presented with a two hour history of chest pain and mild respiratory distress . she reported a dull ache across the anterior chest unrelated to exertion , with some radiation to the left shoulder .
she had no significant past medical history and no prior history of similar chest pain .
physical ... | tako - tsubo cardiomyopathy ( transient left ventricular apical ballooning ) is a reversible form of cardiomyopathy of unknown etiology .
tako - tsubo cardiomyopathy ( ttc ) is typically precipitated by sudden emotional or physical stress , and is associated with excessive sympathetic stimulation and catecholamine re... |
severe acute pancreatitis ( sap ) is an inflammatory disorder characterized by an intricate cascade of events originating from digestive enzyme activation in pancreas acinar cells [ 13 ] .
pancreas , a gland which has both exocrine and endocrine functions with a plenty of secretory cells , depends on high endoplasmic... | endoplasmic reticulum ( er ) stress is a particular process with an imbalance of homeostasis , which plays an important role in pancreatitis , but little is known about how er stress is implicated in severe acute pancreatitis ( sap ) induced pancreatic beta - cell injury . to investigate the effect of 4-phenylbutyric a... |
a 19-year - old , gravida 1 , para 0 woman at 39 weeks gestation with a past medical history notable for mild mental retardation , bipolar disorder and hypothyroidism presented to an outside hospital with bloody emesis and tinnitus after a self - reported ingestion of 100 tablets ( 32.5 g ) of aspirin several hours pri... | acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management . while suggested thresholds exist for hemodialysis in adults with toxic salicylate ingestion , it is unclear if these thresholds remain appropriate for the gravid patie... |
obstructive sleep apnea ( osa ) , characterized by repeated obstructions of upper airway with intermittent hypoxic exposure , is associated with multiple detrimental physiological and psychological consequences , in addition to being associated with cardiorespiratory diseases , including pulmonary hypertension,1 system... | backgroundthe majority of previous neuroimaging studies have demonstrated both structural and functional abnormalities in obstructive sleep apnea ( osa ) .
however , few studies have focused on the regional intensity of spontaneous fluctuations during the resting state and the relationship between the abnormal proper... |
approximately 5,100 isolates of m. tuberculosis complex , predominately from patients in tb control programs in the northeast united states , are part of the wadsworth center spoligotype database . most of these strains have been collected through ongoing sentinel surveillance projects in massachusetts and new york cit... | spacer oligonucleotide ( spoligotyping ) analysis is a rapid polymerase chain reaction based method of dna fingerprinting the mycobacterium tuberculosis complex .
we examined spoligotype data using a bioinformatic tool ( sequence logo analysis ) to elucidate undisclosed phylogenetic relationships and gain insights i... |
atherosclerotic heart disease and chronic heart failure remain a major worldwide health problem . according to the american heart association statistics , over one in three american adults have one or more types of cardiovascular disease resulting in an average of 1 death every 39 seconds .
in addition , millions of ... | despite advances in the fields of prevention , medical intervention and surgical therapy , cardiovascular disease remains a major public healthcare issue .
a promising area of research is the potential application of regenerative therapies with pluripotential stem cells to reduce the burden of heart disease and its s... |
narcotics have been used since long as a component of balanced anaesthesia , thus minimizing the anaesthetic requirement both during induction and maintenance as well as attenuating the pressor response during laryngoscopy and intubation .
equally significant is their role in provision of smoother recovery period by ... | background and aim : narcotics have been used since long as a component of balanced anaesthesia , thus minimizing the anaesthetic requirement both during induction and maintenance as well as attenuating the pressor response during laryngoscopy and intubation .
equally significant is their role in provision of smoothe... |
pain is a highly complex , dynamic , subjective experience that is useful in growing children , serving to warn them of danger and limiting exposure to additional injury .
however , untreated , acute , or recurrent or chronic pain may have significant and lifelong consequences ( both physiologically and psychological... | aim . children with developmental disabilities generally experience more pain than the normal children .
description of pain is generally difficult in children and more so in children with intellectual disabilities .
the study aimed at evaluating dental pain in children with intellectual disabilities . methods .
... |
microbes are the biggest reservoir of biodiversity in natural forests and are involved in nutrient transformations thereby maintaining the forest ecosystem .
there are many natural forest types present in the north eastern region of india and many are still far from human understanding and any kind of anthropogeni... | paired end illumina mi - seq sequencing of 16s rrna gene amplicon was carried out to study the bacterial community in the soil of murlen national park located in indo - burman biodiversity hotspot region .
metagenome consisted of 302,416 reads with 151.81 mb data and g + c content of 56.48% .
more than 85% seque... |
giant serpentine aneurysm was described in 1977 by segel and mclaurin14 ) as a subcategory of giant aneurysms , distinct from the saccular variety .
patients with a large or giant aneurysm of the internal carotid artery ( ica ) located in the paraclinoid area often present with cranial nerve symptoms .
cavernous ic... | this report describes a case of a serpentine fusiform aneurysm of the internal carotid artery in a patient who presented with visual disturbances .
the serpentine aneurysm was treated successfully by coil trapping and occlusion of the parent artery , accompanied by balloon dilation .
nine months post - operatively ... |
there are many advantages of using a gene - based approach to track cellular and molecular activity with a noninvasive imaging platform like magnetic resonance imaging ( mri ) .
gene - based contrast provides longevity of the signal throughout the cell s life cycle .
this approach also enables tracking of inherent ... | using a gene - based approach to track cellular and molecular activity with magnetic resonance imaging ( mri ) has many advantages .
the strong correlation between transverse relaxation rates and total cellular iron content provides a basis for developing sensitive and quantitative detection of mri reporter gene expr... |
gastrointestinal ( gi ) tract is the most frequently involved extranodal site in non - hodgkin 's lymphoma ( nhl ) .
individuals with defects in cellular immunity are prone to develop various types of opportunistic infections .
strongyloides stercoralis is found mainly in tropical and subtropical areas , and has be... | we report the case of a 49-year - old man with a diagnosis of gastric diffuse large b cell non - hodgkin 's lymphoma , treated with two lines of chemotherapy followed by radiotherapy , and presented about 3 months after completing therapy with recurrent episodes of epigastric pain , gastrointestinal ( gi ) bleeding . c... |
vitamin e ( tocopherol ) and vitamin c ( ascorbic acid ) are well - known lipophilic and hydrophilic chain - breaking antioxidants , respectively . because antioxidant activity in homogeneous solutions may not be the same as that in heterogeneous solutions , the antioxidant properties of heterogeneous solutions includi... | drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced .
hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients .
in addition to drug solubilization , drug n... |
multiple sclerosis ( ms ) , as the most common inflammatory demyelinating disease of the central nervous system ( cns ) and also the most common cause of neurological disability at young age , is an inflammatory demyelinating disease characterized by lymphocyte infiltration and inflammation of the cns white matter .
... | objective(s):regulatory t cells , including cd4+cd25+fox3 + and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance . since multiple sclerosis is an inflammatory autoimmune disease , regulatory t cells are considered to be involved in its pathogenesis . in this study
, we i... |
in ireland community mental health care consultations are provided by both primary care and specialised public mental health services . however , unlike the specialised public mental health service consultations , primary care service consultations are not currently free for the majority of irish residents .
patients... | objective . to investigate the preferences of psychiatric patients regarding attendance for their continuing mental health care once stable from a primary care setting as opposed to a specialized psychiatric service setting
. methods .
150 consecutive psychiatric patients attending outpatient review in a community ... |
gastric cancer is one of the most common cancers in korea , and the fourth most common cancer worldwide .
although the proportion of early gastric cancer has increased as a result of routine screening in korea and japan , gastric cancer is often diagnosed in the advanced stage .
however , even after curative surger... | purposethe purpose of this study is to investigate the dosimetric and clinical influence of computed tomography based ( 3-dimensional [ 3d ] ) simulation versus conventional 2-dimensional ( 2d)based simulation in postoperative chemoradiotherapy ( crt ) for patients with advanced gastric cancer in terms of parallel opp... |
the exponential growth in numbers of older adults is unprecedented in the history of the united states .
longer life spans and aging baby boomers will double the population of americans aged 65 years or older during the next couple of decades to about 72 million .
thus , it is expected that , by 2030 , older adults... | introduction .
older african american women are particularly vulnerable to unhealthy lifestyle behaviors such as physical inactivity and the resultant chronic diseases and conditions .
this study explored older african american women 's perception of physical activity as well as facilitators of and barriers to bein... |
osseointegration is the most important factor in successful implant treatment . in the early stage ,
machined surface implants using pure titanium were reported to have achieved successful osseointegration , but there were limitations in case of low volume and quality of bony tissue1 . in addressing these issues , va... | objectivesthe objective of this study is compare the rate of marginal bone resorption around hydroxyapatite - coated implants given different loading times in order to evaluate their stability.materials and methodsthe study was conducted retrospectively for one year , targeting 41 patients whose treatment areas were th... |
the recent us study 2008 alzheimer s disease facts and figures from the authors of the framingham heart study reveals that alzheimer s disease ( ad ) and dementia have outstripped cancer and stroke as a more common cause of death .
we are concerned that this change not only represents a shift in assessment and treat... | baby boomers are individuals born in the years 1946 to 1965 .
the objective of this paper was to define the risk factors for dementia and alzheimer s disease ( ad ) and their relevance to australian baby boomers , with the aim of providing evidence - based guidelines for dementia prevention .
a series of pubmed sea... |
out of the 98% average radiation dose received by humans from natural sources , approximately 52% occurs due to inhalation of radon , thoron and their progeny in the dwellings ( 1 ) .
radon ( 222rn ) , which is considered a noble gas , is colorless , odorless , tasteless and naturally radioactive ( 2 ) .
when inhal... | backgroundbuilding materials and the ventilation rate of a building are two main factors influencing indoor radon and thoron levels ( two radioactive gases which have the most important role in human natural radiation exposure within dwellings).objectivesthis analytical descriptive study was intended to determine the r... |
ultrasonography showed an irregularly shaped hypoechoic mass in the cranial pole of the right kidney .
cytology revealed moderate cellularity smears composed of epithelial cell clusters , which consisted of an exclusive population of oncocytic cells seen in sheets and papillary clusters along with abundant single cel... | case summarya 9-year - old male neutered domestic shorthair cat presented with anorexia .
ultrasonography showed an irregularly shaped hypoechoic mass in the cranial pole of the right kidney .
ultrasound - guided fine - needle aspiration of the renal mass was performed .
cytology revealed moderate cellularity sme... |
epidemiological data indicate that adverse life events during the first few years of life can increase the risk for psychopathology , including drug addiction [ 1 , 2 ] .
in fact , early life stress has been proposed to predict alcohol drinking in adolescence and alcohol abuse and dependence at adulthood ( see for ... | in the present study , we aimed to assess the impact of early life stress , in the form of early maternal deprivation ( md , 24 h on postnatal day , pnd , 9 ) , on voluntary alcohol intake in adolescent male and female wistar rats . during adolescence , from pnd 28 to pnd 50 , voluntary ethanol intake ( 20% , v / v ) ... |
pasteurella multocida ( p. multocida ) is the etiologic agent of bovine pneumonia and hemorrhagic septicemia in cattle which has been estimated to cause huge economic losses .
five capsule types are routinely identified in p. multocida ( a , b , d , e , and f ) and each is generally associated with , but not complete... | the pasteurella multocida capsular type a isolates can cause pneumonia and bovine respiratory disease ( brd ) . in this study , comparative genomics analysis was carried out to identify the virulence genes in two different virulent p. multocida capsular type a isolates ( high virulent pmcq2 and low virulent pmcq6 ) .
... |
the aim of this study was to provide research and collaboration overview of iranian research efforts in the field of traditional medicine during 2010 - 2014 .
this is a bibliometric study using the scopus database as data source , using search affiliation address relevant to traditional medicine and iran as the searc... | background : the aim of this study was to provide research and collaboration overview of iranian research efforts in the field of traditional medicine during 2010-2014.methods:this is a bibliometric study using the scopus database as data source , using search affiliation address relevant to traditional medicine and ir... |
claudin-1 is a member the claudin family of proteins , which are important in tight junction formation 1 .
they play roles in major cellular functions such as growth and adhesion and are responsible for regulating the paracellular transport of molecules 2 .
claudins were first shown to be abnormally expressed in br... | cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased migration , and increased secretion of mmp-2 in a pkc dependent manner , whereas claudin-1 nuclear expression is found in benign nevi .
melanoma cells were transfected with a vector expressing cldn-1 fused to a nuclear localizati... |
eukaryotic
cellular identity , growth , and homeostasis , extending
to the level of organs , systems , and whole organisms depends in part
on refined and adaptive regulatory control of gene expression .
nongenetic determinants of gene expression
variability has highlighted the role of chromatin modifying
e... | epigenetic
enzymes are now targeted to treat the underlying gene
expression dysregulation that contribute to disease pathogenesis .
histone deacetylases ( hdacs ) have shown broad potential in treatments
against cancer and emerging data supports their targeting in the context
of cardiovascular disease and cen... |
central retinal artery occlusion ( crao ) causes painless and sudden visual loss in the affected eye resulting in infarction of the retina with subsequent necrosis .
it accounts for about 1/10,000 visits to ophthalmologists each year ( 1 , 2 ) .
a meaningful recovery of visual acuity occurred in only < 10% of patie... | central retinal artery occlusion ( crao ) causes severe visual loss in affected eye and vision does not recover in more than 90% of the patients .
it is believed that it occurs by occlusion of the central retinal artery with small emboli from atherosclerotic plaque of internal cerebral artery .
retina is a part of ... |
cancer is a major public health problem that can torment everyone in all parts of the world ( 1 ) .
testicular cancer develops in the testis , a part of the male reproductive tract which produces sperm , other male reproductive cells such as sertoli and leydig cells and androgens ( 2).testicular cancer may be due to... | background : it has been suggested that malfunction of immune system may causes testicular cancer .
recently , our understanding of innate immune system has been expanded , by discovery of toll - like receptors ( tlrs ) .
some studies have shown that polymorphisms of tlr2 and 4 may affect on the risk of cancer . ... |
it was 1991less than ten years after the cause of aids had been identified and researchers already thought they might have a successful vaccine .
evidence from several laboratories suggested that it was possible to develop a vaccine against hiv by inoculating individuals with a crippled version of the virus that cou... | this report revisits the accidental discovery that protection against simian immunodeficiency virus ( siv ) infection in the early successful experimental aids vaccine studies in rhesus macaques was due to antibodies directed against human leukocyte antigens ( hlas ) .
the inactivated virus vaccine approach was disca... |
acute ischemic stroke ( ais ) in children is a rare event with an incidence of 1 to 8 per 100 000 children per year .
seizures occur in the first hours in up to 50% . besides vasculopathy , thrombophilia or cardiac disorders , cancer , and chemotherapy
are known predisposing factors for ais . while solid tumors pr... | introduction : acute ischemic stroke ( ais ) is a rare event in infancy . besides vasculopathy , thrombophilia , or cardiac disorders , cancer and chemotherapy are known predisposing factors for ais .
leukemia can be associated with different abnormal coagulation parameters , but severe bleeding or thrombosis occurs ... |
in 1994 , the global project on anti - tuberculosis drug resistance surveillance was initiated by the who and the international union against tuberculosis and lung diseases , aiming to measure the magnitude of drug - resistant tuberculosis and to monitor trends . at this time , a first set of guidelines was developed t... | availability of new diagnostic tools and global commitment towards universal access to tuberculosis care will accelerate capacity of resource - limited countries to monitor anti - tuberculosis drug resistance .
special surveys will be replaced by routine surveillance of drug resistance linked to patient care . |
a retrospective review of the medical records and radiographic imaging was performed . permission to review and present this information
in 2004 , a 65-year - old man sustained a fall from standing height in which he suffered a t10 compression fracture with significant local kyphosis (
figs . 1
and
2
) . com... | the objective of this article is to report a case of a patient with ankylosing spondylitis who sustained a fracture through a prior solid arthrodesis without loosening or changing posterior instrumentation .
there have been few cases reported of a patient with ankylosing spondylitis suffering a fracture through a pri... |
iodine deficiency ( i d ) is the principal factor responsible for abnormal physical and mental development among children .
all age groups are affected by i d , but growing children and pregnant mothers ( pms ) are the most vulnerable as they are sensitive to even marginal i d . during pregnancy ,
the requirement o... | background : uttarakhand state is a known endemic area for iodine deficiency.objective:the present study was conducted with an objective to assess the iodine nutritional status amongst pregnant mothers ( pms ) in districts : pauri ( p ) , nainital ( n ) and udham singh nagar ( usn ) of uttarakhand state.materials and m... |
vitamin k epoxide reductase ( vkor ) enzyme converts vitamin k ( vk ) 2 , 3-epoxide to vk hydroquinone , a required cofactor for the post - translational gamma - carboxylation of several blood coagulation factors ( factors ii , vii , ix , x , protein c and s ) and other vk - dependent proteins , such as osteocalcin bon... | background : genetic variation in the vitamin k epoxide reductase complex ( vkorc1 ) and cytochrome p450 4f2 ( cyp4f2 ) genes were found to be strongly associated with the oral anticoagulant ( oa ) dose requirement .
the distribution of genetic variation in these two genes was found to show large inter- and intra - e... |
motor and cognitive impairments in stroke patients dramatically reduce their independence
in activities of daily living ( adl ) . in particular , the physical symptoms of stroke have a
greater effect on the patients independence than the cognitive component1 . therefore , understanding the relationship
between mo... | [ purpose ] this study aimed to clarify the independent impact of the affected upper and
lower limb , trunk , and unaffected side motor functions on activities of daily living in
stroke patients using partial correlation analysis .
[ subjects and methods ] this
retrospective study included 77 stroke patients . ... |
we report on a 28-year - old woman , who presented two months postpartum after delivering twins with complaints of transient ischemic attack ( tia ) , dyspnea and chest pain .
physical examination demonstrated jugular venous distention ( jvd ) and s3 gallop on cardiac auscultation along with minimal rales and pedal e... | acute coronary syndrome ( acs ) due to embolic phenomenon in the setting of peripartum cardiomyopathy ( ppcm ) and left ventricular mural thrombus is a rare occurrence .
there have been two known cases described in medical literature .
we present a unique case in which catheter - based aspiration thrombectomy was u... |
in early march 2003 , a 26-year - old man was admitted to a general medical ward of the prince of wales hospital ; he had been ill for 1 week with fever , chills , and rigor .
his previous health had been good , and he had no history of recent travel .
physical examination showed a temperature of 40.2c and bronchia... | during the global outbreak of severe acute respiratory syndrome ( sars ) in 2003 , treatment was empiric .
we report the case history of the index patient in a hospital outbreak of sars in hong kong .
the patient recovered after conventional antimicrobial therapy .
further studies are needed to address treatment ... |
mononeuropathy multiplex is a rare complication during the course of chronic hepatitis b , despite various neuropathies following acute hepatitis b having been reported previously .
the serological tests for hepatitis were consistent with chronic active hepatitis b. after treatment with oral prednisone combined with ... | backgroundmononeuropathy multiplex is a rare complication during the course of chronic hepatitis b , despite various neuropathies following acute hepatitis b having been reported previously.case reporta 30-year - old man presented with sensorimotor symptoms in multiple peripheral nerves .
the serological tests for he... |
thyroid hormone is a fundamental regulator of biological processes , including cell proliferation , differentiation , and metabolic balance .
thyroid hormone plays a crucial role in brain development , which is illustrated by the dramatic neurologic impairment observed in untreated neonatal hypothyroidism , a conditi... | thyroid hormone plays a crucial role in the development and function of the nervous system . in order to bind to its nuclear receptor and regulate
gene transcription thyroxine needs to be activated in the brain .
this activation occurs via conversion of thyroxine to t3 , which is catalyzed by the type 2 iodothyroni... |
exposure to air polluted with particles less than 2.5 micron in size is associated epidemiologically with adverse cardiopulmonary health consequences in humans .
the goal of this study was to characterize human pulmonary responses to controlled experimental high - dose exposure to fine and ultrafine magnesium oxide p... | |
the study was funded by the american diabetes association and approved by the university of minnesota institutional review board .
we recruited participants between january 2007 and march 2009 from clinics and communities in the twin cities metro area of minnesota .
patients were either referred to the study by the... | objectivedetermine the efficacy of a home - based walking intervention to improve walking ability and quality of life in people with diabetes and peripheral arterial disease ( pad).research design and methodswe conducted a randomized , controlled , single - blind trial within university - affiliated clinics in our loca... |
dry eye disease is one of the most common public health problems in the field of ophthalmology that causes decreased physical , psychological , social and occupational functioning , and interferes with daily activities like reading , driving , computer work and watching tv .
the effect of this disease on quality of l... | background : dry eye disease is one of the most common public health problems in the field of ophthalmology that causes decreased physical , psychological , social and occupational functioning , and interferes with daily activities like reading , driving , computer work and watching tv .
the effect of this disease on... |
our study sample comprised all patients newly diagnosed with type 1 diabetes consecutively admitted to the steno diabetes center between 1 september 1979 and 31 august 1984 .
nine patients were excluded ; seven because of serious mental illness and two because of microalbuminuria at the onset of diabetes .
plasma 2... | objectiveto evaluate vitamin d as a predictor of all - cause mortality , progression from normoalbuminuria to micro- or macroalbuminuria , and the development of background or proliferative retinopathy in patients with type 1 diabetes.research design and methodsa prospective observational follow - up study in which an ... |
the optimal timing for treatment in dentofacial orthopedics is linked intimately to the identification of periods of accelerated or intense growth that contribute significantly to the correction of skeletal imbalances in an individual patient .
precise evaluation of the developmental stage forms an integral part of b... | objective : this study was done with the following objectives : to estimate dental maturity using the demirjian index ( di ) for the mandibular third molar ; to investigate the relationship between dental maturity and skeletal maturity among growing patients ; to evaluate the use of the mandibular third molar as an adj... |
lipomas are benign , encapsulated tumours of mesenchymal origin , arising from the adipose tissue .
superficial , simple lipomas can grow for many years without causing any functional problems , and they rarely reach very large dimensions .
the surgical excision of giant occipitocervical lipomas is necessary for ae... | lipomas are capsulated benign tumours that are commonly found in all body parts .
a lipoma is a well - defined mesenchymal tumour that arises from the adipose tissue .
although giant lipomas are rare in the head and neck regions , when they are located here , they are most commonly found in the subcutaneous posteri... |
a groundbreaking paradigm shift , the discovery of noncoding rnas ( ncrnas ) , established the conventional
one gene , one protein model to be an oversimplified view of gene regulation .
numerous ncrna classes are now implicated in central nervous system ( cns ) functions ; micrornas ( mirnas ) , natural antisense... | the human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease .
it is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding rnas ( ncrnas ) .
the microrna ( mirna ) class of ncrnas are ubiquitously expressed throughout the... |
since 2000 , over 35,000 new cases of tuberculosis ( tb ) have been recorded annually in korea , raising concerns about an increasing incidence of multidrug - resistant tb ( mdr - tb ) ( 1 ) .
globally , the epidemiological synergy between hiv and tb co - infection and the deadly synergy between hiv and mdr - tb are ... | much controversy surrounds the issue of whether hiv infection is a risk factor for developing multidrug - resistant tuberculosis ( mdr - tb ) . in this study
, we evaluated the prevalence of and risk factors for mdr - tb in hiv - infected patients at the national medical center of korea .
we reviewed the medical re... |
generic mortality scoring systems for children admitted to intensive care units ( icus ) have been developed for use at specific time points in the icu stay .
two systems have been validated in paediatric icus ( picus ) : the paediatric risk of mortality ( prism ) and the paediatric index of mortality ( pim ) .
the... | introductiontwo generic paediatric mortality scoring systems have been validated in the paediatric intensive care unit ( picu ) .
paediatric risk of mortality ( prism ) requires an observation period of 24 hours , and prism iii measures severity at two time points ( at 12 hours and 24 hours ) after admission , which ... |
key clinical messageprimary aldosteronism ( pa ) in pregnancy is rare . due to pharmacological limitations and risks associated with surgical intervention during pregnancy , clinical decision making in this area
is difficult .
we report the shortterm use of eplerenone in the management of hypertension and hypokalem... | |
our synthetic strategy ( figure 2 ) , inspired by stork s elegant synthesis of reserpine , targets a variety of yohimbinoid alkaloid natural products from the elaboration of pentacycles related to 15 , which vary only in the indole moiety .
pentacycle 15 could in turn arise from aminonitrile 16 , where careful tuning... | the yohimbinoid alkaloids have received considerable attention from the synthetic community due to their interesting chemical structures and varied biological activity .
although there have been several elegant syntheses of certain members of this group of alkaloids , a truly unified approach has yet to be developed ... |
hip fracture occurs primarily in the elderly , and is one of the most important causes of disability and death in this age group ( 1 ) .
the number and mean age of the elderly continues to increase , and thus fracture incidence is likely to follow ( 2 - 5 ) . hip fracture is becoming a major health burden worldwide .... | the purpose of study was to determine the incidence of hip fracture in 2001 , to compare this with that of 1991 , and to identify possible causes of change .
patients aged 50 yr or more living in gwangju city and chonnam province , korea , and who sustained a fracture of the hip during 2001 were investigated .
only... |
hepatocellular carcinoma ( hcc ) is a rare tumour in young adults . in older patients , common predisposing conditions include cirrhosis in general , and in particular chronic liver disease associated with persistent hepatitis b and c infection .
however , young patients who develop hcc are less likely to have associ... | this case describes the clinical course and treatment of a 17-year - old male patient with advanced hepatocellular carcinoma ( hcc ) arising in a non - cirrhotic liver .
the disease was thought to be caused by a congenital cholestatic syndrome associated with intermittent oedema in childhood , resembling the rare aag... |
on recognizing the importance of medical laboratory technology and its impact on the health services of saudi arabia , king faisal university ( kfu ) developed a medical laboratory technology program allied to the college of medicine and medical sciences in 1989 .
although the profession of medical laboratory technol... | this paper documents the evolution of the medical laboratory technology ( mlt ) program established in 1989 ( 1408/1409 h ) at the college of medicine and medical sciences , king faisal university .
the rationale , objectives , the general outline of the program as well as methods of instruction and evaluation are di... |
cervical cancer is the third most common cancer in women , and the seventh of overall cancers worldwide , with an estimated 529,000 new cases in the year 2008.1 it has been estimated that more than 87% of the global burden occurs in developing countries , where it accounts for 13% of all female cancers .
high - risk ... | objectiveto determine the feasibility of visual inspection with the use of acetic acid ( via ) as a screening method for cervical cancer , an alternative to the pap smear used in primary health care setting in sudan , and to compare sensitivity , specificity , positive and negative predictive values , and histological ... |
periodontal disease ( pd ) is part of the global burden of disease ( gbd ) .
pd is possibly associated with 200 systemic diseases . published systematic reviews and meta - analyses
indicate that pd is linked to many systemic diseases , such as pulmonary disease , cardiovascular disease , head and neck cancer , surv... | backgroundthis study was performed to test the association between helicobacter pylori ( hp ) and periodontal disease ( pd).material / methodsthis was a case - control study in a comprehensive hospital , including all patients with newly diagnosed pd between 2012 and 2014 as cases and all patients without pd as control... |
hela cells were cultured in dmem ( media tech ) with 10% fetal bovine serum ( hyclone ) and 1% penicillin streptomycin ( invitrogen ) .
hela cells stably expressing m4-blast constructs were established by lentivirus infection followed by selection with 4 g / ml blasticidin ( invitrogen ) .
rin1 wild type , rin1 wer... | stimulation of a receptor tyrosine kinase ( rtk ) , such as egfr , leads to ras activation followed by rin1 activation .
rin1 , in turn , activates rab5 family gtpases , as well as abl tyrosine kinases .
as expected , rin1 expression directly correlates with rab5-mediated egfr endocytosis .
we previously showed t... |
bisphosphonate - related osteonecrosis of the jaws ( bronj ) is an avascular osteonecrosis of the jaws , associated mainly with intravenous administrated bisphosphonates but also with oral bisphosphonates .
intravenous bisphosphonates are used for the management of bone disease and bone metastases , caused by multipl... | the use of intravenous bisphosphonates ( pamidronate or zoledronic acid ) is the cornerstone for the management of multiple myeloma-(mm- ) related bone disease .
however , osteonecrosis of the jaw ( onj ) is a rare , but sometimes difficult to manage , adverse effect of bisphosphonates therapy . a retrospective revie... |
a 13-year - old premenarchal girl presented with a 2 days history of gradually worsening right iliac fossa ( rif ) pain and vomiting .
she had a background of gastroschisis which was corrected at birth with no further complications . on examination her abdomen was soft with localized tenderness and voluntary guardin... | key clinical messagepediatric ovarian torsion is an infrequent diagnosis and it often mimics acute appendicitis .
most cases are due to underlying ovarian pathology and if left untreated , ovarian torsion may eventually cause peritonitis .
emergency exploratory laparoscopy represents a valuable diagnostic and thera... |
on september 6 , 2008 , the article of the title we fought cancer and cancer won was in the newsweek .
the subtitle was that it is time to rethink the war on cancer , after billions spent on research and decades of hit or miss treatments .
the improved understanding of molecular biology in cancer research has le... | active anticancer molecules have been searched from natural products ; many drugs were developed from either natural products or their derivatives following the conventional pharmaceutical paradigm of drug discovery .
however , the advances in the knowledge of cancer biology have led to personalized medicine using mo... |
obsessive - compulsive disorder ( ocd ) is a disabling and distressing disorder , beginning in late second decade or early third decade of life .
however , symptoms can appear in first decade sometimes as early as 2 years . estimated prevalence of ocd in very young children ( 5 - 7 years of age ) is 0.01% which is mu... | obsessive - compulsive disorder ( ocd ) is a very distressing disorder for both patient and caregiver .
usual onset of the disorder is in late second or early third decade of life .
it is diagnosed in children but rarely before 5 years . a case of ocd in a 4-year - old girl is reported here .
diagnostic and thera... |
patients with a diagnosis of rrms who had been prescribed bg-12 were enrolled in this prospective cohort study .
informed consent was obtained from all patients and controls prior to participation in the protocol , which was approved by the university of michigan institutional review board .
patients were between 1... | objective : to test the hypothesis that dimethyl fumarate ( tecfidera , bg-12 ) affects b - cell subsets in patients with relapsing - remitting multiple sclerosis ( rrms).methods : peripheral blood b cells were compared for surface marker expression in patients with rrms prior to initiation of treatment , after 46 mont... |
lynch syndrome ( ls ) , also known as hereditary non - polyposis colorectal cancer ( hnpcc ) , is an uncommon , but not rare , autosomal dominant familial cancer syndrome ( barrow et al . , 2013 ) .
this condition predisposes individuals to colorectal carcinoma ( crc ) as well as various extra - colonic tumours inclu... | highlightslynch syndrome ( ls ) is an uncommon , genetic disorder which predisposes affected individuals to colorectal , endometrial and ovarian malignancies.we report a case of cervical gastric - type adenocarcinoma in a patient with ls.immunohistochemistry for mismatch repair proteins is a useful screening tool in tu... |
staphylococcus aureus strain sa957 was obtained from chang gung children s hospital in taiwan . for genome sequencing ,
a mono - clone of sa957 was picked from lb agar and grown in liquid lb broth at 37 c overnight .
the overnight culture was diluted 40-fold with fresh lb broth and incubated at 37 c to reach log ph... | mutation and selection are both thought to impact significantly the nucleotide composition of bacterial genomes .
earlier studies have compared closely related strains to obtain mutation patterns based on the hypothesis that these bacterial strains had diverged so recently that selection will not have had enough time... |
late adolescents phase is the most active periods of life because of double demand of activity and growth , as a result nutritional needs are extremely important at this phase of time .
although snacking is a well - established eating pattern among adolescents and can be a source of needed nutrients and calories , it... | with the increase in the trend of social networking , celebrations , over a couple of decades weather in the hostel or at home . snacking has become an important aspect of activity .
today teen prefer snacks more than a proper meal .
skipping of meal and nibbling in between meal is a common practice .
the main me... |
we report a case of acute adrenal insufficiency ( aai ) in a patient with antiphospholipid syndrome ( aps ) .
a 44-year - old female patient presented to us with acute abdominal pain associated with recurrent vomiting and giddiness . on examination , her blood pressure was 80/50 mm hg .
etiological work - up reveal... | introduction : we report a case of acute adrenal insufficiency ( aai ) in a patient with antiphospholipid syndrome ( aps).case report : a 44-year - old female patient presented to us with acute abdominal pain associated with recurrent vomiting and giddiness . on examination , her blood pressure was 80/50 mm hg .
syst... |
transporters belonging
to the neurotransmitter : sodium symporter
( nss ) family are expressed in both eukaryotic and prokaryotic organisms . by facilitating the translocation of a wide range
of substrates across cellular membranes ,
the transporters play important
roles in physiological processes such as mai... | the
serotonin ( 5-hydroxytryptamine , 5-ht ) transporter ( sert ) plays
an essential role in the termination of serotonergic neurotransmission
by removing 5-ht from the synaptic cleft into the presynaptic neuron .
it is also of pharmacological importance being targeted by antidepressants
and psychostimulant d... |
ruptured hepatocellular carcinoma ( hcc ) requires immediate diagnosis and treatment due to its high mortality .
the diagnosis is comparatively easy when made based on clinical course , symptoms , and demonstration of hemorrhagic ascites by abdominal paracentesis , but identification of sites of bleeding is important... | the identification of bleeding sites of ruptured hepatocellular carcinoma ( hcc ) is important for immediate treatment .
we experienced a case of ruptured hcc readily treated with transarterial embolization ( tae ) after identification of the bleeding site using contrast - enhanced ultrasonography ( ceus ) with sonaz... |
aflatoxins ( afs ) are carcinogenic , mutagenic , and teratogenic metabolites mainly produced by aspergillus flavus and the very closely related species a. parasiticus ( 1 ) .
these mycotoxins can grow on a wide range of food commodities , including cereals , peanuts , and crops in the eld , but also during postharve... | backgroundaflatoxins are highly toxic secondary metabolites mainly produced by aspergillus parasiticus
. this species can contaminate a wide range of agricultural commodities , including cereals , peanuts , and crops in the field . in recent years ,
research on medicinal herbs , such as pistacia atlantica subsp .
... |
benzo[a]pyrene ( bap ) , an extensively researched
carcinogen and mutagen , belongs to the high - molecular - weight polycyclic
aromatic hydrocarbon ( pah ) group of chemicals .
bap and other pahs
are derived as a result of incomplete combustion and are released
into the environment by both natural and anthro... | benzo[a]pyrene ( bap ) , a polycyclic aromatic hydrocarbon
( pah ) , is one of the major environmental pollutants that causes mutagenesis
and cancer . bap has been shown to accumulate in phytoplankton and
zooplankton .
we have studied the localization and aggregation of bap
in chlorella sp .
, a microalga t... |
a sox10-cre bacterial artificial chromosome ( bac ) construct was generated from the regulatory elements of sox10 within a well - characterized sox10 bac to obtain high levels of cre in nc derivatives .
the construct includes a nuclear localized cre sequence connected to a human growth hormone mrna stabilization sequ... | background & aimsin hirschsprung disease ( hscr ) , neural crest - derived progenitors ( ncps ) fail to completely colonize the intestine so that the enteric nervous system is absent from distal bowel . despite removal of the aganglionic region ,
many hscr patients suffer from residual intestinal dysmotility . to tes... |
our study involved participants drawn from the whitehall ii epidemiological cohort ( 24 ) for psychophysiological testing between 2006 and 2008 . the criteria for entry into the study included no history or objective signs of clinical or subclinical cvd and no previous diagnosis or treatment for hypertension , inflamma... | objectivesthe objective of this study was to examine the association between cortisol response to mental stress and high - sensitivity cardiac troponin t ( hs - ctnt ) in healthy older individuals without history of cardiovascular disease ( cvd).backgroundmental stress is a recognized risk factor for cvd , although the... |
it is certain that the main cause of cardiovascular diseases ( cvd ) backs to early childhood ( 1 - 4 ) .
impairment in the metabolism of carbohydrates leads to increased mortality and morbidity of cardiovascular diseases ( 5 ) .
the number of type ii diabetic patients is increasing in the world , and many of them ... | background : diabetes is associated with increased cardiovascular disease , mortality and morbidity.objectives:the present study aimed at assessing fasting blood sugar ( fbs ) in elementary school students in birjand , 2012.materials and methods : this cross - sectional and descriptive study was done on 1530 elementary... |
in total 99 isolates identified biochemically as members of the genus aeromonas randomly selected from a large collection of nearly 400 aeromonads isolated from different sources during the past two decades in tripoli , libya , were included in the present investigation .
the strains were obtained from diarrheal chil... | introductionaeromonads of medical importance have been reported from numerous clinical , food , and water sources , but identification of genospecies and virulence factors of aeromonas species from countries in north africa and the middle east are few.methodsin total 99 aeromonas species isolates from different sources... |
tumor cells disseminate to distant organs via the lymph or the blood stream during metastasis .
the metastasis includes several critical pathogenic steps which are angiogenesis , invasion into the capillary venules , circulation in the blood stream , adherence to a new local extravasation and colonization .
the arr... | during their passage through the circulatory system , tumor cells undergo extensive interactions with various host cells including endothelial cells and platelets .
mechanisms mediating tumor cell adhesion , migration , and metastasis to vessel wall under flow condition are largely unknown . the aim of this study was... |
hypertrophic olivary degeneration ( hod ) is a transneuronal degeneration of the inferior olivary nucleus in which patients develop hypertrophy of the inferior olivary nucleus following a primary lesion in the dentato - rubro - olivary pathway .
this degeneration is unique ; in that , it causes hypertrophy of the inf... | hypertrophic olivary degeneration ( hod ) is seen following lesions in the guillain mollaret triangle .
this is unique because the inferior olivary nucleus hypertrophies following degeneration unlike the typical atrophy seen in other structures .
we report two cases of hod in two different clinical scenarios . |
gastrointestinal stromal tumors ( gists ) are the most common mesenchymal tumors of the gastrointestinal tract .
gists originate from the interstitial cells of cajal ( icc ) or their stem cell - like precursors [ 1 , 2 ] . most gists express a receptor tyrosine kinase , kit .
kit is encoded by the c - kit gene and ... | this report describes a patient with synchronous sporadic gastrointestinal stromal tumors ( gists ) in the stomach and jejunum . a 71-year - old japanese male presented with a 2-year history of occasional melena and general fatigue .
computed tomography of the abdomen demonstrated an enhanced extramural gastric tumor... |
between june 1996 and june 2002 , ipmt of the pancreas was diagnosed in 64 of our patients on the basis of pathologic examination of surgical specimens . of these 64 , 46 [ m : f = 32:14 ; mean age , 61 ( range , 40 - 77 ) years ] who underwent mrcp and mra during the month preceding surgery were included in this study... | objectiveto compare the usefulness of magnetic resonance cholangiopancreatography ( mrcp ) and mr angiography ( mra ) in differentiating malignant from benign intraductal papillary mucinous tumors of the pancreas ( ipmts ) , and to determine the findings which suggest malignancy.materials and methodsduring a 6-year per... |
tubo - ovarian abscess ( toa ) is a sequela of pelvic inflammatory
disease ( pid ) that is comprised of an infectious , inflammatory complex
encompassing the fallopian tube and ovary .
the proposed
pathophysologic mechanism for toa development includes ascending
infection as well as hematogenous and lymphatic... | background . tubo - ovarian abscess involvement of an endometrioma has been reported in cases of
patients with polymicrobial sources such as neisseria gonorrhoeae , chlamydia trachomatis ,
and obligate anaerobic bacteria ; however , bacterial vaginosis ( bv ) predisposing to abscess formation in
an en... |
in recent years , much focus has been placed on extrinsic causes of dental erosion , such as acidic dietary beverages and citric and phosphoric acids which are often added to soft drinks .
only few studies have focused on the erosive effect of intrinsic acids such as gastric juices even though they have a higher eros... | aim : the aim of this study was to comparatively evaluate the effect of 4% titanium tetrafluoride ( tif4 ) and 1.23% acidic phosphate fluoride ( apf ) gel on the microhardness of human coronal dentin.materials and methods : thirty noncarious extracted premolars were collected and sectioned buccolingually with the help ... |
pure red cell anemia ( prca ) is a syndrome characterized by severe normocytic anemia , reticulocytopenia , and an absence of erythroblasts from an otherwise normal bone marrow .
the acquired form of prca may present as a primary hematologic disorder in the absence of any other diseases , or secondary to various unde... | pure red cell aplasia ( prca ) following allogeneic hematopoietic stem cell transplantation ( hsct ) has been mostly reported in situations involving major abo incompatibility between donor and recipient .
conventional treatments such as plasma exchange , erythropoietin , and steroid are often unsatisfactory .
ritu... |
all surgeries come with an attendant risk of infection , glaucoma filtration surgery being no exception .
literature cites the follow up adjusted incidence ( number of events per patient - year ) of bleb related infection ( bri ) lying in the range of 0.4%6.9% with a follow up ranging from 1.7 years to > 8.5 years.11... | purposecomparison of the demographic , ocular , systemic and microbiological characteristics of eyes with bleb related infection ( bri ) and bleb related endophthalmitis ( bre).methodsretrospective chart review of patients with bri from january 1996july 2013 .
identification done via the center s longstanding endopht... |
alzheimer 's disease ( ad ) is the most prevalent form of dementia , being usually diagnosed in people over 65 years , although the less prevalent early - onset forms of ad develop at earlier ages .
dementia prevalence rises exponentially , doubling the rate of ad every 5 years after the age of 60 with a 15-fold prev... | it is widely accepted that cells serving immune functions in the brain , namely , microglia and astrocytes , are important mediators of pathological phenomena observed in alzheimer 's disease .
however , it is unknown how these cells initiate the response that results in cognitive impairment and neuronal degeneration... |
epidemiological studies show that headache ( ha ) and back pain ( bp ) frequently occur in this age group and are often accompanied by psychological problems.1,2 dysfunctional stress coping strategies refer to maladaptive cognitive or behavioral reactions to stress and strain.3 postal surveys showed that children wit... | backgroundprevious research has shown positive relationships between dysfunctional cognitive styles and different aspects of pain ( eg , pain frequency ) .
one goal of our longitudinal study was to investigate potential risk factors for the incidence of headache ( ha ) and back pain ( bp).methodsin the first wave ( 2... |
the largest family of cancer testis antigens ( ctas ) and one of the most important is the family of melanoma antigen encoding genes ( mage ) .
members of the mage family are involved in resistance to apoptosis and cell cycle progression and have been associated with some features of neoplastic phenotype such as immo... | background . we aimed to investigate a possible role of mage a3 and its associations with infiltrated immune cells in thyroid malignancy , analyzing their utility as a diagnostic and prognostic marker .
materials and methods .
we studied 195 malignant tissues : 154 ptcs and 41 ftcs ; 102 benign tissues : 51 follicu... |
an increasing number of patients are developing pelvic floor laxity . because of the presence of many collateral health problems , all of which vastly increase the risks of surgery , minimally invasive operations are preferable for safety and quality of life .
furthermore , it is suggested that hysterectomy itself ma... | introduction and hypothesisin 2005 , a new minimally invasive procedure , the tissue fixation system ( tfs ) was reported .
like tvt ( tension - free vaginal tape ) , the tfs works by creating a foreign body collagenous tissue reaction that reinforces a weakened pelvic ligament .
the objective was to assess the eff... |
chronic nonbacterial osteomyelitis ( cno ) ( omim number 259680 ) is an autoinflammatory , noninfectious disorder that affects the skeletal system and has first been described in 1972 .
an association with further autoimmune and autoinflammatory disorders such as pustolusis palmoplantaris , chronic inflammatory bowel... | chronic nonbacterial osteomyelitis ( cno ) with its most severe form chronic recurrent multifocal osteomyelitis ( crmo ) is a non - bacterial osteitis of yet unknown origin .
secondary to the absence of both high - titer autoantibodies and autoreactive t lymphocytes , and the association with other autoimmune disease... |
skeletal muscle function is dependent upon stable connections from the contractile elements that generate force to the bony skeleton that translates that force into movement .
efficient transmission of that contractile force is enabled by a highly organized arrangement of support structures both within and around the... | during development , skeletal myoblasts differentiate into myocytes and skeletal myotubes with mature contractile structures that are precisely oriented with respect to surrounding cells and tissues .
establishment of this highly ordered structure requires reciprocal interactions between the differentiating myocytes ... |
we evaluated the outcome of percutaneous vertebroplasty ( pvp ) in the treatment of painful vertebral hemangiomas refractory to medical management .
14 patients ( four thoracic and ten lumbar vertebra ) with painful vertebral hemangiomas presenting with severe back pain for more than 6 months not responding to medica... | background : painful vertebral hemangiomas are often inadequately managed medically .
we evaluated the outcome of percutaneous vertebroplasty ( pvp ) in the treatment of painful vertebral hemangiomas refractory to medical management.materials and methods:14 patients ( four thoracic and ten lumbar vertebra ) with pain... |
, we describe the first case of fatal large bowel ischemia in the aftermath of laparoscopic incisional hernia repair .
a literature search using pubmed was performed to identify all published cases of intestinal ischemia following laparoscopic procedures .
our search revealed 13 cases of intestinal ischemia followi... | background and objectives : intestinal ischemia is a very rare complication of laparoscopic procedures . in this report
, we describe the first case of fatal large bowel ischemia in the aftermath of laparoscopic incisional hernia repair.methods:a literature search using pubmed was performed to identify all published ... |
patients diagnosed with cancer today have improved five - year relative survival compared to just over a decade ago .
treatment advances , including the introduction of targeted agents , continue to improve cancer survival .
however , it is increasingly evident that targeted agents used in cancer therapy may negati... | cardiotoxicity is the second leading cause of morbidity and mortality in cancer survivors .
the objective of this international cardiac oncology survey was to gain a better understanding of current knowledge and practice patterns among hcps involved in the management of cancer patients exposed to potentially cardioto... |
balb / c mice were immunized with purified human pcna protein overexpressed in bl21 cells .
after 3 injections of 0.1 mg protein / mouse mixed with poly i - poly c polymer , the spleen cells of the responding animals were fused with sp2/0-ag14 .
growing clones were screened by elisa using microtiter plates coated w... | antibodies are valuable tools for functional studies in vitro , but their use in living cells remains challenging because they do not naturally cross the cell membrane . here , we present a simple and highly efficient method for the intracytoplasmic delivery of any antibody into cultured cells . by following the fate o... |
cerebral ischemia / reperfusion caused by stroke contributes to worsened neurological outcomes and poor prognosis .
ischemia / reperfusion injury is triggered by a concert of pathological events , leading to inflammation , brain - blood barrier disruption , and neuronal cell death .
current therapeutic strategies f... | objective(s):to investigate the effects of local mild hypothermia on the expression of fas , fasl and mmp-3 after cerebral ischemia - reperfusion in rats.materials and methods : male wistar rats were divided into sham - operated group ( sham ) , normothermia group ( nt ) , and hypothermia group ( ht ) .
mcao / r mode... |
able - bodied muslims abstain from food , fluids , smoking , and taking oral medications between the hours of sunrise and sunset , and usually eat a large meal after sunset and a lighter meal before sunrise .
ramadan is observed by over 400 million of muslims spread across the globe ; and living under various geograp... | fasting during ramadan , the holy month of islam , is mandatory for all healthy adult muslims .
it is estimated that there are 1.1 - 1.5 billion muslims worldwide , comprising 18 - 25% of the world population .
about 62% of the world 's muslim population resides in asia .
women comprise approximately 50% of this ... |
the essential trace element selenium is believed to exert beneficial influence on human health , mainly based on the antioxidant capacity of selenoproteins such as glutathione peroxidases ( gpx ) and thioredoxin reductases ( trxr ) containing the 21 proteinogenic amino acid , selenocysteine , in their active center .
... | the essential trace element selenium has long been considered to exhibit anti - diabetic and insulin - mimetic properties , but recent epidemiological studies indicated supranutritional selenium intake and high plasma selenium levels as possible risk factors for development of type 2 diabetes , pointing to adverse effe... |
l4777 , specification:5000 u g ) was purchased from sigma aldrich ; lipase ak ( pseudomonas fruorescens ) was from amano pharmaceuticals .
lipase psim ( burkholderia cepacia immobilized on diatomaceous earth ) was from amano enzyme europe ltd .
reactions in the continuousflow system were carried out in the hcube... | abstractmany alkaloids containing a tetrahydrocarboline skeleton have wellknown therapeutic effects , leading to increased interest in the synthesis of these natural products .
enantiomers of nbocprotected 1hydroxymethyl1,2,3,4tetrahydrocarboline [ ( )7 ] , 1hydroxymethyl6methoxy1,2,3,4tetrahydrocarboline [ ( )8 ] , ... |
metabolic disorders as defined by the world health organization include disease conditions whose prevalence is reported to be on the increase more so in the developing countries . based on the results of some epidemiological and clinical investigations in the past few decades
, a number of studies have supported the ... | omega-3 polyunsaturated fatty acids ( pufas ) are increasingly being used to prevent cardiovascular diseases , including diabetes and obesity . in this paper , we report data on the observed effects of omega-3 pufa on major metabolic disorders and immune system disruption during gestational diabetes and their consequen... |
it is easier to judge the mind of a man by his questions rather than his answers.pierre-marc-gaston , duc de lvis ( 17641830 ) i get it ; science is just like spelling .
you just have to memorize it and it does n't make any sense.anonymous u.s . elementary school student the juxtaposition of these quotes illustrates... | science begins by asking questions and then seeking answers .
young children understand this intuitively as they explore and try to make sense of their surroundings .
however , science education focuses upon the end game of facts rather than the exploratory root of the scientific process .
encouraging questioni... |
the speakers at this summit included many of the movement 's high profile leaders , including dean ornish , mehmet oz and kenneth pelletier .
evidence of the interest in the broad field of integrative medicine was the inclusion of the program of thomas donahue ( the ceo of the us chamber of commerce ) , george halvor... | the us institute of medical sponsors a summit on integrative medicine and the health of the public on february 2527 , 2009 .
a prestigious body of speakers and attendees created a dynamic conference in which the content and discussions provided vital information for transforming the us health care system .
topics... |
between 1960 and 1990 , several studies evaluated the relationship between the shape and function of the temporomandibular joints ( tmjs ) and concluded that they were intimately related ; therefore , eventual functional loads applied to them exert considerable influence on their morphology .
however , the role of oc... | backgroundthe present study aimed to determine and compare the anteroposterior position of the condyle in the mandibular fossa between groups of asymptomatic subjects with normal occlusion and asymptomatic subjects with class i , class ii division 1 , and class iii malocclusions.material/methodsthirty persons with norm... |
overweight and obesity are exceedingly difficult to reverse . despite the widespread use of conventional management strategies low - calorie diets , physical activity , behavioral interventions , and pharmacological agents
an estimated 65% of all us adults were either overweight or obese during 2007 - 2008 .
overw... | background .
few safe and effective dietary supplements are available to promote weight loss .
we evaluated the safety and efficacy of glucomannan , a water - soluble fiber supplement , for achieving weight loss in overweight and moderately obese individuals consuming self - selected diets .
methods .
participa... |
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