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cc-by | Statistical analysis Results are representative of at least 3-6 independent experiments. The data are presented as the mean plus SEM (standard error of the mean) and were analyzed using the Graph-Pad Prism 5. 03 software (GraphPad Software, San Diego California USA, "www. graphpad. com"). The experiments were analyzed ... | 10.1371/journal.pone.0148640 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Furthermore, the set of genes related to lipid pathways was also analysed through Ingenuity Pathways Analysis Software (Ingenuity Systems, Redwood City, CA; http://www. ingenuity. com) (IPA). Even if these genes are expressed with different dynamics throughout the kinetic, the final number of modulated genes remains th... | 10.1371/journal.pone.0148640 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Localization of LD in Leishmania major infected macrophages To study the dynamics of the LD-Leishmania association in living cells, a time-lapse sequence of BMMs infected with DsRed transgenic parasites was investigated using confocal microscopy. The accumulation of LDs appears as early as 15 min post infection and mas... | 10.1371/journal.pone.0148640 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments SR thanks Pr Gerald Spaeth for giving her free acess to his laboratory and his kind support. SR is also grateful to Mr Laurent Audry for his technical assistance and precious advice and wants to thank all the DIHP lab members for their help with time lapse experiments and Mr Guillermo Arango Duqu... | 10.1371/journal.pone.0148640 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | L. G. T. was supported by funds from European community grant (Proposal number: 37231 ), I. R. was supported by a L'Oréal-UNESCO Pan Arab Regional Fellowship For Women in Science , J. E. was supported by an ERC starting grant (Rupteffects, number 261166 ), and is a member of the LabEx consortia IBEID and Milieu... | 10.1371/journal.pone.0148640 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | All relevant data are within the paper and its Supporting Information files. We also have transcriptomic data available on the GEO (Gene Expression Omnibus) database at www. ncbi. nlm. nih. gov/geo/ under the accession number GSE31995. | 10.1371/journal.pone.0148640 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | No difference in modified Stoke Ankylosing Spondylitis Spine Score was observed between golimumab 50 and 100 mg, and the radiographic rate was stable at 2 and 4 years, suggesting no progression of new bone formation over the course of the study. 25 Conversely, these data indicated no retardation of spinal ossification.... | 10.2147/dddt.s107587 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | effects of golimumab on enthesitis Three scoring systems were used to assess entheseal involvement and changes in entheseal tenderness in patients from the initial 24-week GO-RAISE trial, namely the 12-point Berlin index, the 17-point University of California San Francisco index, and the 13-point Maastricht AS Enthesit... | 10.2147/dddt.s107587 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Refinement Crystal data, data collection and structure refinement details are summarized in Table 2. The coordinates of H atoms of the water molecules and hydroxy groups were obtained from a 356 Diop et al. (C 4 H 7 N 2 ) 2 [Sn(C 2 O 4 ) 2 (H 2 O) 2 ]ÁH 2 O Acta Cryst. (2016). E72, 355-357 research communications Figu... | 10.1107/s2056989016002061 | article | en | 2,016 | true | false | false | false | Chemistry | https://openalex.org/fields/16 |
cc-by | Special details Experimental. X-ray crystallographic data for I were collected from a single-crystal sample, which was mounted on a loop fiber. Data were collected using a Bruker Venture diffractometer equipped with a Photon 100 CMOS Detector, a Helios MX optics and a Kappa goniometer. The crystal-to-detector distance ... | 10.1107/s2056989016002061 | article | en | 2,016 | true | false | false | false | Chemistry | https://openalex.org/fields/16 |
cc-by | Acknowledgements The authors acknowledge the Cheikh Anta Diop University of Dakar (Senegal), the Canada Foundation for Innovation , Universitede Bourgogne and Universitede Montreal for financial support. | 10.1107/s2056989016002061 | article | en | 2,016 | false | false | true | false | Chemistry | https://openalex.org/fields/16 |
cc-by | Model calibration Parameterization was made starting from empirical data on both past influenza epidemics and the 2009 H1N1pdm pandemic. In particular, transmission rates were estimated for the United Kingdom, in such a way that the following conditions were simultaneously satisfied. First, considering age-dependent su... | 10.1371/journal.pcbi.1004681 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | LF, MA, SM received funding from the European Commission Horizon2020 CIMPLEX project. NMF and SC received funding from NIGMS MIDAS. NMF also acknowledges funding from MRC, Bill and Melinda Gates Foundation and NIHR HPRU. SC also acknowledges funding from Labex IBEID, AXA Research Fund and EU FP7 PREDEMICS... | 10.1371/journal.pcbi.1004681 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Chronic glaucoma is a multifactorial disease among which oxidative stress may play a major pathophysiological role. We conducted a systematic review and meta-analysis to evaluate the levels of oxidative and antioxidative stress markers in chronic glaucoma compared with a control group. The PubMed, Cochrane Library, Emb... | 10.1371/journal.pone.0166915 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Literature search We reviewed all studies measuring oxidative or antioxidative stress markers in chronic glaucoma patients and controls. Animal studies were excluded. The PubMed, Cochrane Library, Science Direct and Embase databases were searched on May 10 th 2016, with the following keywords: "oxidative stress" or "ox... | 10.1371/journal.pone.0166915 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical considerations Statistical analysis was conducted using Comprehensive Meta-analysis software (version 2, Biostat Corporation) [20, 21, 22, 23] and Stata software (version 13, StataCorp, College Station, US). Baseline characteristics were summarized for each study sample and reported as mean (standard-devi... | 10.1371/journal.pone.0166915 | review | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | One point was given for each activity correctly recalled, and the percentage of correct responses was computed. The PM task lasted approximately 15 min. In the third phase, participants performed the set of complementary cognitive tasks. During the fourth phase, participants were asked to rate the regularity of each ac... | 10.3402/snp.v6.31238 | article | en | 2,016 | true | false | false | false | Psychology | https://openalex.org/fields/32 |
cc-by | Acknowledgements The authors wish to thank Fabien Cerrotti and Alexandre Aubry for their interest and help in this work and all the participants that took part in the study. The authors also thank the anonymous reviewers for their insightful observations. | 10.3402/snp.v6.31238 | article | en | 2,016 | false | false | true | false | Psychology | https://openalex.org/fields/32 |
cc-by | Background: In the general geriatric population, programs linking geriatric evaluation with interventions are effective for improving functional status and survival of the patients. Whether or not these interventions improve health related quality of life (HRQoL) or overall survival (OS) in older patients with cancer i... | 10.1186/s12885-016-2927-4 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Secondary objectives Secondary objectives are three-fold. First, in the population of elderly cancer patients considered in need of a geriatric assessment (G8 score ≤ 14), we will compare the two treatment strategies in terms of additional endpoints: 6-month objective response, 1-and 3-year progression-free-survival (P... | 10.1186/s12885-016-2927-4 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 1 ). For each arm, patients will be treated according to protocols specifically defined for this trial (See section "Description of the interventions"). If the resulting score is normal (G8 > 14) then patients will be included in the parallel cohort and treated according to the institution's standard management process... | 10.1186/s12885-016-2927-4 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Patients will then be seen every semester during the second and third years during which data on disease progression, HRQoL and vital status will be collected. | 10.1186/s12885-016-2927-4 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | [28]. With regards to HRQoL data, missing data analysis will be performed to determine the missing data profile. Longitudinal models will be fitted to provide a description of the HRQoL over time and investigate effect of the intervention. For patients treated in the "Case-Management" arm, the analysis of geriatric par... | 10.1186/s12885-016-2927-4 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements The authors thank Pippa McKelvie-Sebileau and Dr. Ravi Nookala of Institut Bergonié for medical writing services. | 10.1186/s12885-016-2927-4 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | This pattern of activity is symptomatic of a strong excitability of the neuronal system that can turn into hyperexcitability during pathological crisis. In [29] we have fitted the NMM parameter values for reproducing interictal and pre-ictal spiking activities by tuning the coupling gain of the indirect excitatory fe... | 10.1186/s13408-016-0042-0 | article | en | 2,016 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | This scenario is physiologically relevant insofar as it is conceivable that an excess of extracellular glutamate concentration is regulated after a delay, triggering a decrease of neural activity after the initial increase. Moreover, the frequency after the regulation delay can be greater or lower than the initial one,... | 10.1186/s13408-016-0042-0 | article | en | 2,016 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Acknowledgements This work was performed within the Labex SMART ( ANR-11-LABX-65 ) supported by French state funds managed by the ANR within the Investissements d'Avenir programme under reference ANR-11-IDEX-0004-02. We thank H. Berry for helpful comments on this work. We also thank S. Blanchard and F. We... | 10.1186/s13408-016-0042-0 | article | en | 2,016 | false | false | true | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Acknowledgments This work was supported by grants from Synapsis Foundation , Novartis Foundation for Biomedical Research Basel and the Swiss National Science Foundation (# 31003A_149728 ) to AE. | 10.1016/j.neubiorev.2016.04.012 | review | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | For the wildlife surveillance system, the aim was to involve (i) hunters, (ii) forest rangers, and (iii) the surveillance system coordinator. Focus group discussions and individual interviews were implemented between September 2014 and February 2015 by a single facilitator. All discussions during the interviews were re... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The questionnaire was completed based on the available documentation. The scoring grid was pre-scored by external evaluators (3 persons). The grid was then presented to a panel of experts during a full day meeting, which should be representative of most of the stakeholders involved in the bTB surveillance. The objectiv... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | (ii) A histogram showing the scoring of seven critical control points that were developed by Dufour (1999) [31]. And finally (iii) a radar chart displaying the score of 10 of the evaluation attributes recommended by CDC and WHO [32] : (i) simplicity, (ii) flexibility, (iii) data quality, (iv) acceptability, (v) sen... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Participatory approaches process Stakeholders involved. For the cattle surveillance system, 22 stakeholders were interviewed using 4 focus group discussions and 4 individual interviews. Among these stakeholders, 8 were farmers, 7 were private veterinarians, 2 were representatives from the national reference laboratory,... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The system coordinator was satisfied with her role in the surveillance. She was not completely satisfied with the consequences of the information flow, due to the fact that it could increase conflicts with hunters and increase her workload. Nonetheless, she stated that a suspicion could be useful to collect other relev... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Criteria Score (/3) Taking partners' expectations related to the objective into account 2 Existence of an operational management structure (central unit) 2 Existence of an operational steering structure that is representative of the partners (steering committee) 2 Organization and operations of the system laid down in ... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | e. movement restriction, milk delivery restriction) and to constraints linked to the implementation of follow-up SIT for many years. This acceptability has been defined as very low for farmers, and low for private veterinarians who are in conflicts of interest. Problems were highlighted for wildlife surveillance as wel... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Comparison of the criteria used to assess acceptability with participatory approaches and with the OASIS flash tool. OASIS criteria Participatory approaches criteria / Stakeholders Similar indicators -Taking partners' expectations related to the objective into account -Acceptability of the objective / All -Effective in... | 10.1371/journal.pone.0159041 | article | en | 2,016 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgments We warmly thank the Belgian Chief Veterinary Officer , Pierre Naassens , for permission to conduct this study in Belgium. We would like to extent our acknowledgments to all participants for their implication in this work, and to Jozef Hooyberghs for his comments on this article. | 10.1371/journal.pone.0159041 | article | en | 2,016 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Cetuximab is marketed by Merck. Construction of Vectors-The construction of complementary DNAs encoding c-Myc epitope-tagged human PLC␥ 1 (1291 amino acids, accession number ABB84466), human PLC␥ 2 (1265 amino acids, accession number NP_002652), and F897Q mutant of PLC␥ 2 was described previously (34). The constructio... | 10.1074/jbc.m116.746842 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Label-free Quantitative Mass Spectrometry-Equal volumes (5 l each) of purified wild-type or R665W mutant PLC␥ 2 were mixed with 300 fmol of the Pierce TM peptide retention time calibration mixture (PRTC, catalog no. 88320, ThermoFisher) containing 15 known synthetic tryptic peptides. Samples were reduced for 20 min at ... | 10.1074/jbc.m116.746842 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | For relative quantitation, the precursor ions area detector node within Proteome Discoverer TM was used; preceding event detection was set to 4 ppm. Measurement of PLC Activity in Vitro-Phospholipase C activity was determined as described (64, 66) with minor modifications. In brief, aliquots (10 l) of purified PLC␥ 2... | 10.1074/jbc.m116.746842 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Miscellaneous-SDS-PAGE and immunoblotting were performed according to standard protocols using antibodies reactive against the c-Myc epitope for wild-type and mutant PLC␥ 2. Immunoreactive proteins were visualized using the ECL Western blotting detection system (GE Healthcare). All experiments were performed at least t... | 10.1074/jbc.m116.746842 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The simpler model was selected unless the extra sum of squares F-test had a p value of less than 0. 05. Repeated measures analysis of variance with Tukey's post test contained in the GraphPad InStat software package (version 3. 10; GraphPad Software, La Jolla, CA) was used for the statistical analysis of the data shown... | 10.1074/jbc.m116.746842 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments-The expert technical assistance of Susanne Gierschik and Norbert Zanker is greatly appreciated. | 10.1074/jbc.m116.746842 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Patient Population This study is an observational case-control study performed at the University Hospital of Bordeaux. Fifty patients with POAG (20 men, 30 women, mean age 61. 9 +/-6. 9 years) and 50 age-and sex-matched controls (20 men, 30 women, mean age 61. 9 +/-7. 0 years) were prospectively included. This research... | 10.1167/iovs.16-19838 | article | en | 2,016 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Measurement of DTI metrics along the optic radiations From the DTI data, the distortions induced by eddy currents were first corrected, then a diffusion tensor model was fitted at each voxel using Olea Medical ® software to generate fractional anisotropy (FA) maps and to investigate the microstructural integrity of the... | 10.1167/iovs.16-19838 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis Statistical analysis was performed using SAS 9. 3 (SAS Institute Inc, Cary, NC). | 10.1167/iovs.16-19838 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | DTI could represent a future way to explore central nervous system of glaucomatous subjects, leading to a better understanding of the pathophysiology and, potentially, to help clinical trials evaluate new therapeutic strategies based on neuroprotection or brain repair. Green boxes are the markers placed manually on ant... | 10.1167/iovs.16-19838 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Gene expression analysis by quantitative PCR Real-time qPCR was performed in a Light Cycler 480 (Roche Diagnostics, Risch, Swiss) using the LC FastStart DNA Master SYBR Green I kit (Roche Diagnostics). Amplification was initiated with an enzyme activation step at 95°C for 10 min, followed by 40 cycles consisting of 20s... | 10.1371/journal.pone.0146177 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | They were covalently linked with fluorescein isothiocyanate (FITC) or indodicarbocyanin (Cy5) at the 5 0 -end (Thermo Fischer Scientific GmbH, Ulm, Germany). All the following steps were performed in the dark, a volume of 150 μl of hybridization solution was added to each well and cells were pelleted at 4000g for 15 mi... | 10.1371/journal.pone.0146177 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis Results are represented as mean±SEM. Statistical analysis were performed by Mann-Whitney and Kruskal-Wallis tests (Graphpad Prism, Graphpad Software Inc, La Jolla, California); p<0,05 was considered statistically significant. The NCSS9 software (Kaysville, Utah) was used for principal component ana... | 10.1371/journal.pone.0146177 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors thank Mylène Levant and the Animex plateform for animal husbandry. We also thank Dr. Moez Rhimi for gift of E. coli culture. | 10.1371/journal.pone.0146177 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Methodology We have been conducting sociological research into the Calanques National Park since 2008. This began in the context of two research programmes, one focused on the consultation process surrounding the creation of the park (Deldrève and Deboudt, 2012) and the other interested in land-and sea-based uses of ... | 10.5380/dma.v38i0.44352 | article | en | 2,016 | true | false | false | false | Social Sciences | https://openalex.org/fields/33 |
cc-by | Among the users interviewed who did not participate in the consultation process, 125 were met directly onsite, primarily in one land-based area and three sea-based locations. The chosen land area -the Marseilleveyre massif between the Mont-Rose and Marseilleveyre Calanques -is one of the entry points into the Calanques... | 10.5380/dma.v38i0.44352 | article | en | 2,016 | false | true | false | false | Social Sciences | https://openalex.org/fields/33 |
cc-by | The second principle required the representation of a majority of users and activities from the sites. In keeping with these procedural norms, members of the GIP managerial team specifically identified groups of people who appeared most organized and legitimate. As a result, the aforementioned recreational users of the... | 10.5380/dma.v38i0.44352 | article | en | 2,016 | true | false | false | false | Social Sciences | https://openalex.org/fields/33 |
cc-by | Using manual curation based on the known biological, physiological or functional relevance to the disease of the candidate genes, we were left with a single homozygous variant in the PIK3R4 gene, named herein VPS15: p. Arg998Gln, c. 2993G4A, Chr3:(GRCh37):g. 130422672C4T. The variant and its cosegregation with the phen... | 10.1038/ncomms13586 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Nowadays, new ciliopathy causative genes are very likely to be identified in very few if not unique families. One explanation could be that the gene involved may code for an essential protein for which only a very limited number of mutation sites may be tolerated, the remaining mutational sites being probably lethal. H... | 10.1038/ncomms13586 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Variant filtering was performed with the VaRank programme 36 using stringent criteria excluding (i) non-pathogenic variants defined in dbSNP 138, (ii) variants represented with an allele frequency of more than 1% in dbSNP, the Exome Variant Server, the Thousand Genomes Project Catalog and the ExAC database, (iii) varia... | 10.1038/ncomms13586 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The cilia length from the base to the tip was measured using the ImageJ program on confocal images, and the length of each primary cilia was determined for 120 to 200 cells per sample (ctrl1, ctrl2, ctrl3, II. 1, II. 3, II. 5 and BBS4 À / À ). Transient transfection for GFP-2XFYVE HRS and VPS15-HA plasmids. The fibrobl... | 10.1038/ncomms13586 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgements We warmly thank the members of the family for their participation. We thank J. L. Mandel and the financial support of the Centre Regional de Genetique Medicale de Strasbourg and the Caisse d'Assurance Retraite et de la Santeau Travail Alsace-Moselle. We also thank RETINA France ( 100 Exomes Prog... | 10.1038/ncomms13586 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | We thank B. Rinaldi , D. Stuber and L. Kuhn ( CNRS/UDS, Strasbourg, France ) for technical help and R. Poncelet-Bach for schematic representation of cilia trafficking. This work was funded by INSERM (to H. D. and S. B. ), CNRS (to S. F. ), Universitede Strasbourg (H. D. , S. F. and IDEX 2015 Attractiviteto... | 10.1038/ncomms13586 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Data availability. The whole-exome sequencing data have been deposited at the European Genome-Phenome Archive (EGA), which is hosted by the European Bioinformatics Institute (EBI) and the Centre for Genomic Regulation (CRG), under accession number EGAS00001002075. The rest of the data that support the findings of this ... | 10.1038/ncomms13586 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Introduction As previously described in mAbs, a debate is in progress regarding whether the nomenclature of therapeutic antibodies would be based henceforthor noton the percentage of nucleotide sequence identity between the genomic DNA encoding the variable regions of a given antibody and the closest human variable gen... | 10.1080/19420862.2016.1255520 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments and disclosures This work was supported by the French Higher Education and Research Ministry under the program " Investissements d'Avenir " grant agreement: LabEx MAbImprove ANR-10-LABX-53-01. We thank Dr. Paul Parren and Dr. Alain Beck for their helpful comments. The authors declare no competi... | 10.1080/19420862.2016.1255520 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Introduction The pooled or meta-analysis of regional brain volumes derived from T1-weighted MRI data across multiple sites is reliable when data is acquired with similar acquisition parameters [1, 2, 3]. The inherent scanner-and sequence-related noise of MRI volumetrics under heterogeneous acquisition parameters has p... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | The remaining ROIs are reported in the supplemental materials. Test-retest reliability, defined as ICC(1,1) [35] , was computed across each site and protocol for the selected metrics using the "psych" package in R [36]. The between-site ICC(2,1) values were computed following the procedure from previous studies on mu... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | false | true | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | Scaling Factor Validation Scaling factor estimates were validated under the assumption of scaled, systematic error, in 2 ways: first, by simulating power curves that take into account the uncertainty of the scaling factor estimate, and second, by a leave-one-out calibration. For the simulation, we generate data for eac... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | Coefficients were set on the intercept as 63. 135 cm 3 , β 10 as -. 95 cm 3 , covariates Z Age as -. 25 cm 3 /year and Z Gender as 4. 6 cm 3. scGM volumes were generated in a linear model using these coefficients and additional noise was added from the residuals, which were sampled from a normal distribution with zero ... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | In [44] , researchers developed a method to more accurately estimate partial volume effects using only T1-weighed images from the ADNI dataset. This approach resulted in higher classification accuracy between Alzheimer's disease (AD) patients and mild cognitively impaired (MCI) patients from normal controls (NL). Desi... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | Methods such as those employed by Wang and colleagues may be preferred over standard segmentation pipelines when data acquisition is not standardized. Due to its wide range of acquisition parameters and size of the dataset, our approach could be used to evaluate such generalized pipelines in the future. The above deriv... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | Alternatively, multisite studies employing our approach can use the results of our direct-volume calibration (the estimates of CV a for each ROI) to estimate sample sizes based on our proposed power equation and bias measurements without acquiring their own human phantom dataset to use in calibration. To our knowledge,... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | On the other hand, CV a is invariant to true subject variability, but is limited by the accuracy of between-site scaling estimates. Both between-site ICC and CV a should be reported when evaluating multisite reliability datasets to understand a given algorithm's ability to differentiate between subjects (via the ICC) a... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | true | false | false | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | The equation for power we outlined in this study along with our measurements of variability between sites should help researchers undestand the trade-off between protocol harmonization and sample size optimization, along with the choice of outcome metrics. Our statistical model and bias measurements enables collaborati... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | false | false | true | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | Acknowledgments We thank the study participants, MR technicians, and acknowledge Stephane Lehéricy , Eric Bardinet , Frédéric Humbert and Antoine Burgos from the ICM IRM facility (CENIR) and the CIC Pitié-Salpêtrière for their expertise. Funding was provided by R01 NS049477. Additional support was provided b... | 10.1016/j.neuroimage.2016.03.051 | article | en | 2,016 | false | false | true | false | Economics, Econometrics and Finance | https://openalex.org/fields/20 |
cc-by | ACKNOWLEDGMENTS This study was supported by INSERM , Joint Transnational Call 2011 for "Integrated Research on Genomics and Pathophysiology of the Metabolic Syndrome and the Diseases arising from It" from l ' Agence Nationale de la Recherche (ANR) of France (PLT) ; the Lefoulon-Delalande Foundation ; and the Franco... | 10.1016/j.kint.2016.04.014 | review | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | We evaluated EuroTravNet (a GeoSentinel subnetwork) data from June 2013 to May 2016 on 508 ill travellers returning from Brazil, to inform a risk analysis for Europeans visiting the 2016 Olympic and Paralympic Games in Brazil. Few dengue fever cases (n = 3) and no cases of chikungunya were documented during the 2013-15... | 10.2807/1560-7917.es.2016.21.27.30278 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | EuroTravNet and study inclusion criteria EuroTravNet, a subnetwork of GeoSentinel [1] , comprises 22 European sites specialised in travel or tropical medicine that report clinician-based data on ill travellers [2]. Sites enter anonymised data on demographics, travel history, reason for travel, pre-travel advice, hosp... | 10.2807/1560-7917.es.2016.21.27.30278 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Background International mass gatherings pose a risk for communicable disease outbreaks and onward rapid, global spread of infection [3]. The Olympic Games will take place mainly in Rio de Janeiro, Brazil, on 5-21 August 2016, followed by the Paralympic Games, on 7-18 September 2016. More than 400,000 visitors to the ... | 10.2807/1560-7917.es.2016.21.27.30278 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements GeoSentinel, the Global Surveillance Network of the International Society of Travel Medicine (ISTM) , is supported by a Cooperative Agreement ( U50/CCU412347 ) from the United States Centers for Disease Control and Prevention (CDC) and funding from the ISTM. | 10.2807/1560-7917.es.2016.21.27.30278 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Study Population and Follow-up for Cancer Incidence Detailed information on the study design, rationale and methods of the EPIC study, including assessment of diet and lifestyle factors, has been described previously (17, 18). Briefly, between 1991 and 2000 more than 520,000 men and women aged 20-85 years were recruit... | 10.1158/1940-6207.capr-15-0434 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Serum Biomarkers Data for HBV and HCV seropositivity, for AFP and C-reactive protein (CRP) levels and for liver function tests, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), albumin and total bilirubin were available and measured as previo... | 10.1158/1940-6207.capr-15-0434 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Potential effect modifications of the association between OPN levels and HCC risk by sex, age at recruitment, years of follow-up, baseline and lifetime alcohol consumption, and smoking status were evaluated in separate analyses by including interaction terms formed by the product of modifying variable categories and th... | 10.1158/1940-6207.capr-15-0434 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Drinkers at recruitment indicated alcohol intake at baseline, but did not have past alcohol intake. Lifetime drinkers were defined as those who indicated alcohol intake at both baseline and prior. All the categories of alcohol exposures assessed are mutually exclusive. Statistical significance of interactions (p<0. 05)... | 10.1158/1940-6207.capr-15-0434 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Financial Support: This work was supported by NIH R01 CA120719 to LB and by the French National Cancer Institute (Institut National du Cancer; INCA) grant number 2009-139 to MJ. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) ; and the International Agency for Research ... | 10.1158/1940-6207.capr-15-0434 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Methods We use CP-BOLD data from controlled canine (10) experiments imaged at rest, under baseline and severe LAD occlusion (ischemia). We delineate manually all myocardial borders to have ground truth. Based on these delineations we learn dictionaries (examples shown in Figure 1a ) to describe a given patch (a small ... | 10.1186/1532-429x-18-s1-w27 | article | en | 2,016 | true | false | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | Conclusions We outlined a series of algorithms that can segment, register and analyze these datasets. While more evaluation is necessary, BOLD does provide unique opportunities to study the heart without any contrast and stress. | 10.1186/1532-429x-18-s1-w27 | article | en | 2,016 | true | false | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | Methods Survey instrument. We conducted an online 28-item survey consisting of multiple choice and Likertscale questions (see Supplementary Table S1 ). A short introduction specified that the survey was not addressing the use of gene expression profiling assays that evaluate the risk of recurrence in early breast canc... | 10.1038/srep22517 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Statistical analysis. Descriptive analysis was undertaken using Excel software from Microsoft Office. Multivariable logistic regression modeling was carried out to determine the relationship between predictors and either the use of tumor genome sequencing (Yes or No) or the expressed degree of confidence to interpret t... | 10.1038/srep22517 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgements The authors would like to thank the European Society for Medical Oncology (ESMO) , European School of Oncology (ESO) , the Breast International Group (BIG) the Belgian Society of Medical Oncology (BSMO) , the French Breast Cancer Intergroup UNICANCER (UCBG) and the Associazione Italina di Oncolog... | 10.1038/srep22517 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Subjects were free to withdraw from the study at any time. They could also withdraw or be withdrawn if they experienced serious adverse events, if it was thought that continuing to participate in the study would compromise their health, or if they failed to comply with study protocol. The study was reviewed and approve... | 10.1371/journal.pone.0149219 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Intervention, randomization and blinding, and examination schedule The study protocol has been previously described elsewhere [19]. In brief, eligible subjects were randomized in a 1:1 ratio to receive 3 capsules daily containing 280 mg DHA each (Reti-Nat 1 , provided by Bausch & Lomb), the effective DHA dose being 84... | 10.1371/journal.pone.0149219 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | At baseline, clinical and ophthalmologic examinations of potentially eligible subjects were checked against inclusion/exclusion criteria. Data recorded included socio-demographic information, relevant ocular and medical history, and concomitant treatment. Biological samples were collected at baseline examination before... | 10.1371/journal.pone.0149219 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Finally, background leveling for a drusen image was combined with the well-known, histogram-based Otsu method [36] for background selection of input to the model and final threshold selection to achieve a largely automated method of drusen segmentation (Fig 2 ) [37]. This algorithm also extends to segmentation of r... | 10.1371/journal.pone.0149219 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Difference for gender, smoking and CFH and ARMS2 polymorphims between DHA and placebo group was assessed by Chi² test. (Table 1 ). We compared drusen characteristics between baseline and 3 years according to treatment group (DHA vs. placebo) using paired T test. (Table 2 ). Associations of DHA supplementation with dr... | 10.1371/journal.pone.0149219 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | (Table 4 ). Statistical analyses were performed using SAS 1 9. 2 (SAS Institute Inc. , Cary, NC, USA). | 10.1371/journal.pone.0149219 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data Sets Analyzed Among the 300 randomized subjects, a total of 298 subjects were included in the Safety Set (150 subjects in the DHA group and 148 in the placebo group). The FAS (all subjects in the safety set with at least one post-baseline assessment of CNV) consisted of 134 subjects in the DHA group and 129 in the... | 10.1371/journal.pone.0149219 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 17; p = 0. 003). Women tended to show a greater reduction in total drusen diameter in the inner subfield with the CFH polymorphism (TT) genotype than with the heterozygous or homozygous risk alleles (CT\CC) (p = 0. 03), Concerning drusen area remodeling, we found that drusen area in the inner subfield was also reduced ... | 10.1371/journal.pone.0149219 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments Meeting Presentation: Presented in part at ARVO 2011, Oral Presentation, Abstract # 6642. | 10.1371/journal.pone.0149219 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Analysis of anti-HBsAg, anti-E1 and anti-E2 antibody responses Anti-HBsAg antibodies were quantified with the ARCHITECT system (Abbott Laboratories). Anti-E1 and anti-E2 responses were evaluated with "in-house" ELISAs, based on the use of solid phases consisting of lysates of baby hamster kidney (BHK-21) cells expressi... | 10.1371/journal.pone.0151626 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | (B), An immunoassay using human monoclonal antibodies recognizing conformation-dependent discontinuous epitopes on the E2 protein (AR3A) and the folded E1-E2 complex (AR5A) demonstrated the productive folding and heterodimerization of HCV envelope proteins in the context of fusion proteins. The monoclonal antibodies AR... | 10.1371/journal.pone.0151626 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We would like to thank Dr. Takaji Wakita for the JFH-1 virus strain, Dr. Jens Bukh for the chimeric JFH-1 genomes H77/JFH1 , J4/JFH1 , S52/JFH1 and ED43/JFH1 , Dr. Charles Rice for the Huh7. 5 cell line, Dr. Jean Dubuisson for the mAb H52, Dr Harry Greenberg for the mAb A4, Dr. Camille S... | 10.1371/journal.pone.0151626 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
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