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cc-by | In addition, data are lacking on how the pattern of response may change with different treatment regimens (e. g. , monthly dosing versus an individualized approach). To address these limitations, we conducted this review using data from HARBOR [7, 10] and CATT [8, 9] , as well as from MARINA [5] and ANCHOR [6]. ... | 10.1159/000451065 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical Analysis Data were analyzed at month 3 to identify those subjects who achieved early VA gains with treatment, and at month 12 to identify those with a delayed response who achieved VA gains between BCVA data, as assessed by the Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity chart, were ana... | 10.1159/000451065 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors thank Dr. Karen O'Leary and Dr. Elaine O'Prey from Novartis Ireland for editorial assistance. | 10.1159/000451065 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors thank Dr. Karen O'Leary and Dr. Elaine O'Prey from Novartis Ireland for editorial assistance. | 10.1159/000451065 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | cerevisiae's RPD3. These genes are now designated as RPD31 and RPD32. The current annotation of these genes has given rise to some confusion, with discrepancies between the original publication (Srikantha et al. , 2001) and the current annotation in the Candida Genome Database (CGD; Assembly 22,. Table 1 presents ... | 10.3389/fmicb.2016.01238 | review | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | ACKNOWLEDGMENTS MCh is supported by a fellowship from the Région Rhône Alpes (France). MCo and JG's groups received funding from the ANR trough the FungiBET ANR-14-CE16-0027-02 program. JG's group has also received support from French National Agency for Research (ANR) through the EpiGam ANR-11-PDOC-0011 and t... | 10.3389/fmicb.2016.01238 | review | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Combination antiretroviral therapy (ART) based on ≥3 antiretroviral drugs including either a protease inhibitor (PI), nonnucleoside reverse transcriptase inhibitor (NNRTI), or integrase inhibitor has substantially improved the prognosis of human immunodeficiency virus type 1 (HIV-1)-infected patients since its introduc... | 10.1093/cid/ciw183 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Study Sample The ART-CC, which is described in detail elsewhere (http://www. art-cohort-collaboration. org) [10] , is an international collaboration of HIV cohort studies from North America and Europe that combines data on HIV-infected individuals aged ≥16 years who were antiretroviral-naive when they started ART with... | 10.1093/cid/ciw183 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The data used here included follow-up from 1996 until 31 July 2013. We included patients who started ART between 1996 and 2001 (so had at least 12 years of potential follow-up) and had at least 1 available baseline (within 3 months prior to starting ART) measurement of CD4 count and viral load. | 10.1093/cid/ciw183 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical Analysis We categorized CD4 counts into 6 groups (0-49, 50-99, 100-199, 200-349, 350-499, and ≥500 cells/µL); viral loads into 3 groups (0-9999, 10 000-99 999, and ≥100 000 copies/µL); age at baseline into 5 groups (16-29, 30-39, 40-49, 50-59, and ≥60 years); year of starting ART into 3 groups (1996-1997, ... | 10.1093/cid/ciw183 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | We used unadjusted (Kaplan-Meier) and adjusted estimates of cumulative mortality to examine whether CD4 count at start of ART was prognostic for mortality. The adjusted estimates were for a typical patient: men who have sex with men (MSM) aged 30-39 years, who started ART between 1998 and 1999 in the French Hospital Da... | 10.1093/cid/ciw183 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Relative survival models based on generalized linear models (modified Poisson models) were used to account for variation in background population mortality [11]. Expected death rates for each country split by sex and 5-year age group were obtained from the Human Mortality Database (www. mortality. org). We estimated a... | 10.1093/cid/ciw183 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements Université Paris 13 , Sorbonne Paris Cité and Centre de la Recherche Scientifique (CNRS) were grateful acknowledged for financial support. | 10.3762/bjoc.12.130 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | We tested our model at a range of [Ca 2+ ]'s between 0. 001 and 10 μM for five SL's ranging from 1. 85 to 2. 25 μm. Single overlap length x max increases with SL according to the formulation of Rice et al [22] , the equations of which are presented in the S1 Appendix (Eq A1-A3). The parameters C s , C f and K CaTn0 we... | 10.1371/journal.pcbi.1005126 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | [18]. In the MechChem model, tension was obtained by solving Eq 9 numerically in Matlab (MathWorks, Natick, MA) with the ode23 solver. | 10.1371/journal.pcbi.1005126 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Model limitations The model presented here assumes that when an area on the thin filament becomes unblocked, XB's are automatically formed. Thus, the fraction of unblocking is proportional to the XBforce developed along the strand. The assumption that XB's form automatically when RU's are activated is not physiological... | 10.1371/journal.pcbi.1005126 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The greatest asset of such an approach is its unbiased nature, which does not focus on preselected regulatory circuits and conditions. Simultaneously, it allows comprehensive and precise mapping of all transcriptome parts such as transcription units, non-coding RNA species, and transcription start sites. Taking the afo... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | To elucidate the main physiological adaptations caused by the biological conditions of our study, we conducted a Principal Component Analysis (PCA). This approach allowed assessing the general relationships between the 156 RNA samples in terms of expression profiles composed of aggregated values for all annotated genes... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The different categories of terminal regions are 5'UTR (green boxes) and three classes of 3' regions: 3'UTR (red) ending with a defined termination site, 3'NT (orange) without defined termination site, and 3'PT (old yellow) downstream a site of partial termination. Two categories of intergenic regions are distinguished... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The complete results are available in S6 Our study identified nearly all (48/50) of the (predicted) non-coding RNAs of S. aureus NCTC 8325 from the Rfam database [53] , including the generic RNAs 6S RNA, 4. 5S RNA, tmRNA, RNase P, 33 cis-acting 5'-UTRs, and 11 small regulatory RNAs (sRNAs) including RNAIII [54] and ... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The remaining sRNA, S414, exhibited very low expression levels under all conditions tested in our study except for growth in human plasma. The identification of these new sRNA candidates will likely facilitate the identification of new components of the regulatory network of S. aureus since recent studies revealed impo... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Transcription factor binding site analysis to predict new regulon members Coordinated regulation of promoter activities is summarized in the promoter correlation tree and the associated clustering: 1242 up-shifts (82%) belonged to 16 activity clusters with 15 members defined by a cutoff on average Pearson correlation s... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | aureus and a few other Staphylococcus species. According to the SHOW CDS prediction software [71] the confidence probability associated with this putative CDS is also very low (value of 0. 18). For these reasons we assume that S596 may be a trans-encoded sRNA rather than a cis-encoded ASRNA. Indeed, the occurrence an... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Applying a 30 bp distance cut-off, these elements were searched using the TransTermHP software [48]. They were found for 67% of the 1261 identified high-confidence down-shifts (Figure I in S1 Data, S7 Table ) suggesting that intrinsic, also known as Rho-independent, termination determines the 3'-end of a majority of t... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | S. aureus has a genome markedly more A+T-rich (67. 2%) than B. subtilis (56. 5%) and E. coli (49. 2%). We therefore wanted to examine to what extent different genome compositions may lead to a different rate of random occurrence of the TATAAT hexamer that corresponds to the canonical core of the -10 box for the houseke... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | RNA preparation and tiling array hybridization Total RNA was prepared by acid-phenol extraction after mechanical cell disruption as described previously [13]. The tiling array used in this study contains 383,452 probes covering both strands of the S. aureus NCTC 8325 genome with a tiling step of 18 nucleotides [113].... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The precision in the mapping of upshifts was determined previously [13] by a comparison of the up-shift positions detected in B. subtilis with transcription start sites mapped by a differential RNA-seq approach [118] , which revealed that the resolution is within the range of the tiling step with a tendency to have ... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Sequence analysis of transcript 5'-ends and 3'-ends The classification of promoters based on the presence of sigma factor binding site motifs around the up-shifts (-60bp, +40bp) was performed with the software 'treemm' [13] that also takes into account expression profiles across hybridizations. This analysis allowed ... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The resulting position weight matrices were used as queries in MAST searches against the database of the sequences around the up-shifts (-100bp, +50bp; E-value cut-off 1). In keeping with the orientations of binding sites listed for S. aureus in RegPrecise we considered only the occurrences with the same orientation as... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Two categories of intergenic regions are distinguished: intra (dark blue) for strictly intracistronic regions, and inter (light blue) for regions where the downstream gene can be transcribed from its own promoter. Finally, depending of the presence or absence of a defined termination site, independent segments decompos... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | This work was supported by CEU projects LSHG-CT-2006-037469 (BaSysBio) and LSHM-CT-2006-019064 (StaphDynamics); the Top Institute Pharma projects T4-213 and T4-502 ; the Institut Pasteur ; CNRS ; the ANR projects ANR-08-ALIA-0011 NABAB and ANR-09-MIEN-0010 GRABIRON; the outside the human body. | 10.1371/journal.pgen.1005962 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Tiling array data have been deposited in the NCBI's Gene Expression Omnibus (GEO) database (accession numbers GSE70040, 70041, 70042, and 70043). All other data are within the paper and its Supporting Information files. | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data availability The S. aureus Expression Data Browser at http://genome. jouy. inra. fr/aeb/ can be accessed through the study website http://genome. jouy. inra. fr/aeb/supplementary_data. html. The website also provides links to access the data sets deposited in GEO (records GSE70040-43). | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Two categories of intergenic regions are distinguished: intra (dark blue) for strictly intracistronic regions, and inter (light blue) for regions where the downstream gene can be transcribed from its own promoter. Finally, depending of the presence or absence of a defined termination site, independent segments decompos... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | b Regions defined from positions up-regulated in at least one of the four experimental conditions (RPMI exp, RPMI t4, TSB exp, TSB t4). c Cumulated length. d Maximum length. e Fraction of regions overlapping GenBank annotated genes and new expression segments detected in the wild-type. f Fraction of regions antisense t... | 10.1371/journal.pgen.1005962 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Case selection We included 75 consecutive sCJD cases from the collection of the Austrian Reference Centre for Human Prion diseases, where all areas for the full state-of-the-art characterization of different neurodegenerative disorders were available (38). For comparison of the complex tauopathy seen in a subset of sC... | 10.1111/bpa.12411 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | This observation has important implications for the application of this epitope for dementia diagnostics. In particular, pTau epitopes vary considerably even during the same disease process (35). Thus, depending on the tau pathological process (neuronal or glial predominant or mixed forms) (34) , CSF pTau examination... | 10.1111/bpa.12411 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | ACKNOWLEDGMENTS The Austrian Reference Centre for Human Prion Diseases is supported by the Federal Ministry of Health , Austria. Cardiobiotec is authorized by the French Ministry of Social Affairs and Health ( DC2011-1437 ) with transfer authorization ( AC 2013-1867 ). P. P. L. and B. S are supported by the Healt... | 10.1111/bpa.12411 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Patients We reviewed 82 cases of PL diagnosed between 2008 and 2014, collected from 42,145 samples registered in Lymphopath, a government-supported network of expert hematopathologists which conducts a systematic review of all newly diagnosed or suspected lymphomas in France. 27, 28 The diagnosis of PL was based on his... | 10.3324/haematol.2016.141978 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis Comparison of clinicopathological, immunological, and genetic features between EBV -and EBV + patients was carried out using c 2 test (or Fisher exact test when required). Event-free survival was determined from time of diagnosis until time of death, progression or last follow up. Survival curves w... | 10.3324/haematol.2016.141978 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We thank Laurence Jalabert , Audray Benest and Gabrielle Perez for immunohistochemistry staining and FISH studies (IUCT, Toulouse, France) and Marina Bousquet for reviewing the paper. We thank François-Xavier Frenois for whole slide imaging (IUCT Toulouse, France). We thank the Lymphopath cons... | 10.3324/haematol.2016.141978 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Patients Patients were eligible if they were over 65 years of age and presented with symptomatic, measurable, newly diagnosed multiple myeloma. Between September 2012 and September 2014, a total of 56 newly diagnosed elderly MM patients were treated in 6 institutions in France. The diagnosis, clinical staging and progn... | 10.3324/haematol.2016.150334 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | This prospective observational study was approved by the Ethics Committee/Institutional Review Board of Paris Île de France V and registered as clinicaltrials. gov identifier: 01671826. | 10.3324/haematol.2016.150334 | article | en | 2,016 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Autologous stem cell transplantation in elderly myeloma patients Statistical analysis was performed with a 2-sided a = 0. 05 and a 95% confidence interval. Data were analyzed using R software, v. 2. 15. 1, and IBM SPSS statistics v. 22. | 10.3324/haematol.2016.150334 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements T. Flament , E. Diot and S. Marchand-Adam were responsible for the conception and design. All authors were responsible for analysis and interpretation, and drafting the manuscript and revision for important intellectual content. | 10.1183/16000617.0011-2016 | review | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Next generation sequencing (NGS) was performed at Molecular Research DNA (MR DNA -Shallowater, TX, USA) on a MiSeq following the manufacturer's guidelines. Sequence data were processed using MR DNA analysis pipeline (MR DNA, Shallowater, TX, USA). Tissue preparation for histological analysis. Flushed colons were opened... | 10.1038/srep19399 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Slides were mounted using Fluorescent Mounting Medium (Dako). Tissues were visualized using a microscope Nikon Eclipse Ni-E and the NIS-Elements analysis software (Nikon Instruments Inc. , Melville, NY). The mean of fluorescence intensity (MFI) and the area of colonic tissue (area) of each imagen was measured using Ima... | 10.1038/srep19399 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Results Microbiota abundance of F. prausnitzii impacts on colonic hypersensitivity and permeability in a non-inflammatory NMS-induced murine model. Next generation sequencing (NGS) of the 16 S genes were performed by Illumina on fecal samples of NMS mice compared to control non handled (NH) mice, just after weaning (We... | 10.1038/srep19399 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements Authors would like to thank Jean-Marc Chatel and Chantal Bridonneau for their advices during this work and M2ISH team for their help concerning Claudin-2 experiments. This study was a part of FPARIS collaborative project selected and supported by the Vitagora Competitive Cluster and funded by the... | 10.1038/srep19399 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Number of times this article has been viewed ] [12] [13] [14] [15] Owing to its uniform expression on malignant cells in HL and sALCL, CD30 has emerged as an attractive target for the treatment of these lymphomas. The antibody-drug conjugate brentuximab vedotin (BV) delivers the potent microtubuledisrupting agent mono... | 10.2147/ott.s96175 | article | en | 2,016 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors would like to thank Dana A Kennedy and Eric Sievers ( Seattle Genetics, Inc. ) for their contributions to the study design and conduct, and Yinghui Wang ( Seattle Genetics, Inc. ) for statistical guidance. Medical editorial assistance was provided by Tara Ruest and Ann Yeung ( Scie... | 10.2147/ott.s96175 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | 15, 16 The 6MST has been used to assess exercise tolerance in the context of PR. 17, 18 However, the correlation between the 6MST and validated indices used to measure exercise capacity (6MWT and CPET) has not yet been established. The primary objective of this study was to analyze the correlations between exercise to... | 10.2147/copd.s98635 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Material and methods This monocentric retrospective study included COPD patients managed by outpatient PR. Patients included in this study were those who had completed the entire PR program and those for whom pre-rehabilitation 6MWT, 6MST, and CPET assessment data were available. The severity of COPD was evaluated by G... | 10.2147/copd.s98635 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Results One hundred seventy-seven COPD patients were managed by outpatient PR between January 2010 and December 2014. Ninety-one (51%) of these patients completed a pre-rehabilitation assessment comprising all three tests (6MST, 6MWT, and CPET) and were included in this study. Another 86 patients (49%) were excluded du... | 10.2147/copd.s98635 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The total β-cell volume was analyzed as previously described. 21, 38, 70 Images were captured with an inverted microscope (Nikon Instruments, Amstelveen, The Netherlands) equipped with a Hamamatsu digital camera c10600 (Olympus) or with a multiphoton microscope (LSM710 NLO with a TiSa laser, Zeiss, Thornwood, NY, USA) ... | 10.1038/cddis.2016.171 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis. Data were analyzed using GraphPad Prism 5 (GraphPad Software, San Diego, CA, USA) and are expressed as mean ± S. E. M. of at least three independent experiments. Data were analyzed by unpaired two-tailed Student's t-test or with one-way or two-way ANOVA with Bonferroni post-hoc test and were consi... | 10.1038/cddis.2016.171 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements. We thank Dr Bin Gao ( NIH, Laboratory of Liver Diseases, Bethesda, MA, USA ) for providing STAT3lox:lox mice, and Ann Demarré , Veerle Laurysens , Jan De Jonge , Erik Quartier and Gaby Schoonjans for technical assistance. Financial support was from the Fund for Scientific Research Flanders ... | 10.1038/cddis.2016.171 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | 001) (Figure 1B ). Mean tumor weight was significantly decreased in mice that responded to sunitinib treatment compared to controls (P < 0. 001) and in responders compared to mice whose tumors progressed (P < 0. 001); within each group, tumor volume correlated with tumor weight, which was measured after mice were sacr... | 10.18632/oncotarget.9542 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Relative to the placebo, statistically significant changes in gene expression (1. 75-fold or greater; p ≤ 0. 05) were observed for 925 genes (245 increased, 680 decreased) in the responders and 181 genes (21 increased, 160 decreased) in the progressive groups (Data File S1). As this is a large number of genes, we sough... | 10.18632/oncotarget.9542 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | To identify the known direct and indirect interactions between the protein products of these genes, we input the lists of Metacore selected genes into the String database, revealing a remarkably strong node in the responders centered on a mass of genes involved in protein translation (Figure 5A ), while interactions i... | 10.18632/oncotarget.9542 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Sorafenib second line following sunitinib progression 1 Translation_Translation initiation 2 Proteolysis_Ubiquitin-proteasomal proteolysis 3 Transcription_mRNA processing 4 Cell cycle_Mitosis 5 Translation_Elongation-Termination 6 Translation_Elongation-Termination_test 7 Cell cycle_G1-S 8 Cell cycle_G2-M 9 Cytoskeleto... | 10.18632/oncotarget.9542 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The images were captured and analyzed with a Zeiss Observer Z1 microscope. Quantifications were performed using Histolab software (Microvision, France). For the immunofluorescence assay, tumor slices were incubated with CD31, CD10, or von Willebrand factor (FvW) primary antibodies, followed by incubation with the secon... | 10.18632/oncotarget.9542 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Double immunofluorescent staining was performed on a Discovery XT (Roche, France) by coincubating tissue sections with the two bounded primary antibodies. Tissue sections were analyzed on a motorized Z-axis BX63 Olympus microscope (Rungis, France). Each fluorescent immunostaining was captured through a UPlan Fl/40 × /0... | 10.18632/oncotarget.9542 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Results were expressed as n-fold differences in target gene expression relative to the TBP gene (an endogenous RNA control) and relative to a calibrator (1× sample), consisting of the cell line sample from our tested series that contained the smallest amount of target gene mRNA. For microarray experiments, isolated RNA... | 10.18632/oncotarget.9542 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical relevance was determined using ANOVA with a Benjamini Hochberg FDR multiple testing correction (p-value < 0. 05). Data were then limited by fold change analysis to statistically relevant data points demonstrating a 1. 75-fold or greater alteration in expression of each gene when averaging the normalized val... | 10.18632/oncotarget.9542 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistics All statistical analyses were performed using GraphPad Prism, Version 5. 00, GraphPad Software. A nonlinear regression curve fit (1-phase exponential decay) was used to analyze dose response experiments. Twotailed unpaired t test was used to calculate the significance of differences between groups (NS, not s... | 10.18632/oncotarget.9542 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | ACKNOWLEDGMENTS Editorial assistance in the preparation of this manuscript was provided by ApotheCom (Yardley, PA, USA ) and was funded by Novartis Pharmaceuticals Corporation. | 10.18632/oncotarget.9542 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Because the current applied is high compared to the physiological current involved in ion exchange, the test can be considered a "stress test" for sweat glands. Two measurements on three different Sudoscan devices were performed under usual testing conditions on each HV and PTD2. Measurements were performed in the same... | 10.3389/fendo.2016.00018 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analyses Comparison of measures recorded at different times on the three different devices was performed according to the ISO 5725-2 standard "Accuracy (trueness and precision) of measurement methods and results -Part 2: Basic method for the determination of repeatability and reproducibility of a standard m... | 10.3389/fendo.2016.00018 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | ReSULtS The databases for this Report have been deposited in a public repository (figshare). Access is provided using the following link: http://figshare. com/s/f7792f2093c411e5b7e706ec4bbcf141 -Demographics. xlsx contains the demographic information of the healthy controls and diabetic patients, with each individual d... | 10.3389/fendo.2016.00018 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | aCKNoWLeDGMeNtS The authors would like to thank Alice Vilier for contribution to the initial project design, statistical plan, and data analysis. | 10.3389/fendo.2016.00018 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | NMR spectroscopy Spectra were recorded at 298 K using a Bruker Avance III 700 MHz spectrometer equipped with a triple resonance-gradient standard probe. Topspin version 2. 1 (Bruker BioSpin) was used for data collection. Spectra processing used NMRPipe (Delaglio et al. 1995) followed by analysis with Sparky 3 (T. D. ... | 10.1261/rna.059733.116 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Relaxation rates and error calculations were determined using NMRViewJ (Johnson and Blevins 1994). Backbone 1 H, 13 C, and 15 N chemical shift assignments for MEC-8 RRM1 were deposited in the Biological Magnetic Resonance Data Bank (BMRB) as entry 26922. | 10.1261/rna.059733.116 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Crystal cryo-protection involved soaking for 5 min in a solution composed of 6. 7% (v/v) isopropanol, 6. 7% (v/v) PEG4000, and 25% (v/v) glycerol. Diffraction data were collected at the European Synchrotron Radiation Facility beam line ID23-2 and processed using the program XDS (Kabsch 2010). The unbound structure was... | 10.1261/rna.059733.116 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 2004 ). Structural coordinates and data have been deposited in the Protein Data Bank as PDB ID codes 5BJR and 5TKZ for the unbound and ligand bound MEC-8 RRM1, respectively. | 10.1261/rna.059733.116 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | ACKNOWLEDGMENTS We thank Gavin Collie for final preparation of crystals and synchrotron data collection. Additional assistance and advice were provided by Lionel Beaurepaire , Brice Kauffmann , Axel Innis , and Sébastien Fribourg. Brune Vialet provided synthesis of the RNA oligonucleotides. Access to NMR spectro... | 10.1261/rna.059733.116 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments Supported by the Fondation pour la Recherche Medicale, Agence National pour la Recherche and Association Francaise contre les Myopathies. Open Access This chapter is distributed under the terms of the Creative Commons Attribution-Noncommercial 2. 5 License (http://creativecommons. org/licenses/by-nc/2.... | 10.1007/978-4-431-54628-3_23 | book-chapter | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Data, imaging, and EUS-FNA at inclusion The clinical data recorded were age, gender, medical history, circumstances of diagnosis, and symptoms related to IPMN. All patients underwent helical triple-phase CT examinations and MRCP was performed in 81 % of patients [8, 11]. EUS-FNA procedures were performed, as previousl... | 10.1055/s-0042-117216 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analyses Results are expressed as mean ± SE. Qualitative and quantitative data were analyzed using Student's t-test, the chi-squared test, or Fisher's exact test, and Spearman's and Pearson's correlation tests, as appropriate, using GraphPad-Instat (version 3. 1a) and GraphPad-Prims (version 6) software. | 10.1055/s-0042-117216 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | ! In this prospective study, we investigated a subgroup of IPMN patients who had clinical predictors of malignancy assessed at diagnosis. We demonstrated that when the KRAS-mutation analysis was added to the cytopathology data from EUS-FNA materials, this improved the ability to diagnose malignancy. This is of importan... | 10.1055/s-0042-117216 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Numerical simulations of regeneration in the presence of bone defect In order to describe the physical situation in which a hole is produced inside bone tissue, the continuum mixture model proposed in Section 3 can be used. We consider the geometry reproduced in Figure 3 : our specimen is composed of a rectangular-sha... | 10.1177/1081286516651473 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 2. 1. Participants. The study sample was recruited in six languages (The Netherlands, UK/USA, Finland, France, Germany, and Italy). Data from this patient sample was also published in von Steinbüchel et al. [16, 17]. Around 45% of the patients were in outpatient treatment during participation in our study, and the othe... | 10.1155/2016/7928014 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data Analysis. Concerning the generic and diseasespecific HRQoL instruments (SF-36 and QOLIBRI, resp. ) classical psychometric criteria were investigated (mean, standard deviations (SD), skewness of item distribution, floor and ceiling effects per scale, kurtosis, and Cronbach's alpha, as well as convergent and discrim... | 10.1155/2016/7928014 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | To be able to investigate whether disease-specific and generic HRQoL share similar correlates, the QOLIBRI Total score and SF-36 MCS and PCS representing the outcomes (predicted values) and a number of sociodemographic, psychosocial, and health-related variables, known from the literature as predictors and correlates, ... | 10.1155/2016/7928014 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | However, in HRQoL research SI has been defined using logarithm base 2 in the formula [34]. In order to assure continuity we decided to define the Shannon index by logarithm base 2. Therefore, we also determined that each score defined a category. After summing up the answers of each person to an individual person scor... | 10.1155/2016/7928014 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors are grateful to all researchers who helped in collecting data in each country and to the patients who provided them. They wish to cordially thank Dr. Ralph Telgmann for revision of the paper and technical assistance in the preparation. This work was generously founded by the ZNS-Hannelore... | 10.1155/2016/7928014 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | The type of language used in the messages was also assessed (Table 2 ). No coding process (manual or software aided) was used since the media content analysis method does not require it but several descriptors were 'counted' , such as the number of posts that used a 'cautious tone' , or complained about poor medical p... | 10.1186/s12955-016-0568-6 | article | en | 2,016 | true | true | false | false | Social Sciences | https://openalex.org/fields/33 |
cc-by | Acknowledgments The authors gratefully acknowledge Dr. Heather Beanlands , Lori Seeley , and an anonymous reader for reviewing an early draft of this paper. Many thanks to Dr. Sylvia Novac who edited the manuscript. | 10.1186/s12955-016-0568-6 | article | en | 2,016 | false | false | true | false | Social Sciences | https://openalex.org/fields/33 |
cc-by | Availability of data and materials The dataset that was analyzed to support the conclusions of this article is available from the Association nationale des malades du cancer de la prostate in http://anamacap. fr/temoignages-cancer-prostate. php. Webpage "Vos témoignages". | 10.1186/s12955-016-0568-6 | article | en | 2,016 | true | false | false | false | Social Sciences | https://openalex.org/fields/33 |
cc-by | Study design and patients The observational, multicenter study sponsored by Clovis Oncology enrolled patients between April 2011 and June 2013 and was designed to prospectively collect matched blood and tumor tissue from newly diagnosed or relapsed patients with advanced (stage IIIB, IV) NSCLC. The observational study ... | 10.1158/1078-0432.ccr-15-1260 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 001; Fig. 2B and C ). We were able to confirm these initial observations in 72 patients, 34 of which overlapped the initial BEAMing dataset, using the cobas EGFR plasma test (P < 0. 001; Supplementary Table S7 ). We performed a logistic regression analysis to look for other clinical characteristics that might predict... | 10.1158/1078-0432.ccr-15-1260 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | A strength of our study is that >90% of all cases evaluated had matched tumor tissue and plasma prospectively collected within 60 days of one another. With tissue as the reference method, the positive percent agreement (PPA) observed for activating mutations between plasma and tumor was 82% for BEAMing (49/60) and 73% ... | 10.1158/1078-0432.ccr-15-1260 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors thank the patients for their participation in the study and the study staff who were involved in collecting specimen material at the study sites. The authors also thank Boreal Genomics for their participation in the comparative platform study, and Andy Simmons and Thomas Harding for co... | 10.1158/1078-0432.ccr-15-1260 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors thank the patients for their participation in the study and the study staff who were involved in collecting specimen material at the study sites. The authors also thank Boreal Genomics for their participation in the comparative platform study, and Andy Simmons and Thomas Harding for co... | 10.1158/1078-0432.ccr-15-1260 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Patients We conducted a retrospective multicenter study of patients with TA in whom aortic surgery was performed and aortic tissue specimen was available for analysis. All patients fulfilled the American College of Rheumatology and the Sharma-modified Ishikawa criteria for TA (10, 11). Demographic, medical history, la... | 10.3389/fimmu.2016.00158 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The resulting fluorescence was detected with a Zeiss Axiovert 200 M microscope equipped with an AxioCam MRm version 3 camera, an ApoTome ® system, and AxioVision ® image capture software. | 10.3389/fimmu.2016.00158 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Expression analysis were performed using the Limma package to identify genes that met statistical significance (P < 0. 05 after adjustment according to the method of Benjamini and Hochberg and fold-change criteria (at least a 1. 5-fold change) for differential expression using the following contrasts: macrophages infec... | 10.1371/journal.pone.0148640 | article | en | 2,016 | true | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | dchip clustering The affymetrix 1. 07 array data related to lipid pathways were analysed using dChip software (http://www. biostat. harvard. edu/~cli/dchip_2010_01. exe) in order to identify clusters regulated later or earlier throughout the kinetic of Leishmania. major infection between Live and Killed parasite infect... | 10.1371/journal.pone.0148640 | article | en | 2,016 | true | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Ingenuity global functional analysis Ingenuity Pathways Analysis (IPA; Ingenuity, CA; Systems 2008) tool was used to identify relevant lipid canonical pathways in macrophages that were altered by Leishmania parasite infection, based on a Fischer's exact test to calculate a p-value for each biological function founded (... | 10.1371/journal.pone.0148640 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | LD evaluation in live cells For live imaging, macrophages were seeded in 96 well plates (Optical Bottom Plate, Black Polystyrene, Cell Culture Treated and Sterile; Thermo scientific) and infected with transgenic Ds-Red or WT parasites for time-courses ranging from 15 min to 24 h. Extracellular parasites were then washe... | 10.1371/journal.pone.0148640 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
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