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Study Procedures | Eligible patients were randomly assigned in a 1:1 ratio to 2 treatment arms: a 3-week regimen (125 mg/m | PMC10712902 | ||
Endpoints and Assessment | death, SD, Cancer | DISEASE PROGRESSION, ADVERSE EVENT, DISEASE, SECONDARY, CANCER | The primary endpoint was progression-free survival (PFS), the time from randomization to disease progression or death from any cause, whichever occurred first. The secondary endpoints included the objective response rate (ORR, defined as the proportion of patients with the best overall response of the complete response... | PMC10712902 |
Statistical Analysis | tumor | DISEASE PROGRESSION, TUMOR PROGRESSION, TUMOR | The trial was powered to assess PFS between the 2 different dose schedules of Efficacy analyses were performed in the full analysis set (FAS) population who had received at least one dose of the study drug. For the primary analysis of PFS, data for patients who were alive and did not have disease progression, lost to f... | PMC10712902 |
Outcome Notes | ADVERSE EVENTS | See Baseline demographic and clinical characteristics.Data are median (range) or
Abbreviation: DFS: disease-free survival.Treatment exposure and dose modifications.Data are mean (SD) or
Summary of adverse events.Efficacy outcomes of progression-free survival (PFS) in the FAS population. (Efficacy outcomes of progress... | PMC10712902 | |
Funding | This study was sponsored by CSPC Ouyi Pharmaceutical Co., Ltd. | PMC10712902 | ||
Conflict of Interest | The authors indicated no financial relationships. | PMC10712902 | ||
Data Availability | The data underlying this article will be shared on reasonable request to the corresponding author. | PMC10712902 | ||
IRB Approval | Cancer | CANCER | Ethics committee of Peking University Cancer Hospital & Institute (Approval No. 2018YJZ52). | PMC10712902 |
References | PMC10712902 | |||
Material and Methods | PMC10620860 | |||
Ethical Statement | This prospective, randomized observational study was conducted at the Pusan National University Hospital. The study was approved by the Institutional Review Board of the Pusan National University Hospital (IRB number: D-1910-027-083, Busan, South Korea) and was registered with the Clinical Research Information Service ... | PMC10620860 | ||
Patients | knee arthroplasty, cognitive impairment, TKA, psychiatric disorders | CRANIAL NERVE DISORDERS | Patients with American Society of Anesthesiologists (ASA) physical status I or II aged ≥65 years who were scheduled for elective total knee arthroplasty (TKA) under spinal anesthesia were eligible. The exclusion criteria were as follows: contraindications to spinal anesthesia; refusal of sedation during surgery; previo... | PMC10620860 |
Grouping | anxiety | The primary endpoint of this study was to determine different anxiety levels and identify the corresponding frequency bands. The purpose of dividing the patients into three groups was not for inter-group comparisons but rather to vary the levels of anxiety. Therefore, 60 patients were randomly assigned to one of the th... | PMC10620860 | |
Spinal anesthesia and management | hypotension | QUINCKE, COLD, DECUBITUS | All patients received routine preoperative care without premedication. On arrival in the operating room, standard monitoring was initiated, including noninvasive automated blood pressure, electrocardiography, and pulse oximetry. Spinal anesthesia was induced in the lateral decubitus position using a 25-gauge Quincke sp... | PMC10620860 |
Measurement of anxiety and sedation | anxiety | The state and trait anxiety inventory (STAI) scores were used to assess anxiety during this study | PMC10620860 | |
Functional near-infrared spectroscopy (fNIRS) measurement using NIRSIT ON | NIRSIT | Functional NIRS (fNIRS) was measured continuously for 10 min in each session using NIRSIT ON (OBELAB Inc., Seoul, Republic of Korea) that can measure cerebral oxygen saturation (rSOThe NIRSIT ON sensor is independently composed of two patches (Figure The power of each bandwidth (BW) was calculated within frequencies be... | PMC10620860 | |
Outcome variables | All variables were measured repeatedly over three sessions (session 1: pre-anesthetic period, session 2: immediately after the spinal anesthesia period, and session 3: normal saline or dexmedetomidine administration period) for 10 min each. At each session, vital signs (mean blood pressure (MBP), heart rate (HR), and o... | PMC10620860 | ||
Statistical analysis | Statistical analyses were performed using SPSS version 24 (IBM Corp., Armonk, NY, USA), R | PMC10620860 | ||
Results | anxiety | A total of 67 patients scheduled for TKA were assessed for eligibility, and seven were excluded (five due to spinal block failure and two for refusal of sedation). The remaining 60 patients were assigned to one of the three groups and completed the study (Figure Table Patient characteristics and the variables assessed ... | PMC10620860 | |
REFERENCES | PMC10247238 | |||
Background | clear cell renal cell carcinoma, renal cancer | CLEAR CELL RENAL CELL CARCINOMA, RENAL CANCER | Small (< 4 cm) clear cell renal cell carcinoma (ccRCC) is the most common type of small renal cancer and its prognosis is poor. However, conventional radiological characteristics obtained by computed tomography (CT) are not sufficient to predict the nuclear grade of small ccRCC before surgery. | PMC10561466 |
Methods | REGRESSION | A total of 113 patients with histologically confirmed ccRCC were randomly assigned to the training set (n = 67) and the testing set (n = 46). The baseline and CT imaging data of the patients were evaluated statistically to develop a clinical model. A radiomics model was created, and the radiomics score (Rad-score) was ... | PMC10561466 | |
Results | REV | The radiomics model was constructed using six features obtained from the CT images. The shape and relative enhancement value of the nephrographic phase (REV of the NP) were found to be independent risk factors in the clinical model. The area under the curve (AUC) values for the training and testing sets for the clinica... | PMC10561466 | |
Conclusion | The CT-based radiomics nomogram has the potential to be a noninvasive and preoperative method for predicting the WHO/ISUP grade of small ccRCC. | PMC10561466 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12885-023-11454-5. | PMC10561466 | ||
Keywords | PMC10561466 | |||
Introduction | RCCs, renal cell carcinoma, aggressiveness, RCC | RENAL CELL CARCINOMA, BENIGN TUMORS, RCC | The increasing use of cross-sectional imaging in recent decades has led to an increase in the incidence of renal cell carcinoma (RCC) [Most small RCCs appear as benign tumors, but some can exhibit high aggressiveness and have the potential to spread to the perirenal fat or distant locations [The most popular noninvasiv... | PMC10561466 |
Patients and methods | PMC10561466 | |||
Patients | high-grade small ccRCC, a renal tumor, Tumors, kidney tumors, tumors | TUMORS, RECRUITMENT, TUMORS, KIDNEY TUMORS | The Institutional Ethics Committee approved this retrospective study and waived the need for patient consent. The study included patients who underwent abdominal CT scans and were diagnosed with a renal tumor at our institution between January 2016 and January 2022. The inclusion criteria were as follows: (1) Patients ... | PMC10561466 |
CT imaging acquisition | Routine clinical CT scans of the kidney are typically performed using 64-slice multidetector CT equipment. The CT scan parameters are as follows: the tube voltage is 120 kV-140 kV; tube current is 250mA-400 mA; slice thickness is 5 mm. Approximately 80 to 100 mL (1.5mL/kg) of contrast agents (Omnipaque, GE Healthcare) ... | PMC10561466 | ||
Traditional radiological characteristics analysis | tumor, calcification, necrosis | CORTEX, TUMOR, LYMPH NODE METASTASIS, NECROSIS | Two radiologists, Reader 1 and Reader 2, with 5 and 10 years of experience in diagnostic abdominal radiology, respectively, conducted a thorough review of the CT images. In cases where there was a disagreement between the two radiologists, they would engage in joint discussions to reach a consensus. The evaluation of t... | PMC10561466 |
Construction of the clinical model | The differences between clinic-radiological characteristics of high-grade and low-grade small ccRCC were analyzed using univariate analysis. For categorical variables, the Chi-square test or Fisher exact test was used, while for continuous variables, the | PMC10561466 | ||
Tumor segmentation and extraction of radiomics features | tumor | TUMOR, RENAL TUMORS | Figure
Schematic diagram of a radiomics study of renal tumors
Manual three-dimensional (3D) of the tumor. a, b and c are the unenhanced phase (UP), the corticomedullary phase (CMP) and the nephrographic phase (NP), respectively. d is 3D volumetric reconstructionThe extraction of features was performed using the Artifi... | PMC10561466 |
Construction of the radiomics model | REGRESSION | To reduce redundant features and mitigate overfitting in the developed radiomics model, the following steps were undertaken for the features in the training set: (1) Features with an ICC greater than 0.75 were selected, (2) Univariate logistic analysis was conducted to identify the features that exhibited statistical s... | PMC10561466 | |
Construction of radiomics nomogram and evaluation model performance | Clinical variables and Rad-score were combined to create a nomogram. Calibration curves were utilized to evaluate the calibration of the nomogram. The Hosmer-Lemeshow test was applied to assess the nomogram’s goodness of fit. The receiver operator characteristic (ROC) curves were utilized to evaluate the discrimination... | PMC10561466 | ||
Correlation between rad-score and immune infiltration | kidney tumor | KIDNEY TUMOR, INFILTRATION | To assess the correlation between Rad-score and immune infiltration, we collected immunohistochemical images from 40 patients with small ccRCC and evaluated a total of 12 immunomarkers. Subsequently, hierarchical clustering analyses were performed for specific immunomarkers. We selected paraffin-embedded kidney tumor t... | PMC10561466 |
Statistical analysis | Python software (v.3.6.0) and R software (v.3.5.1) were used to perform the statistical analysis. A statistically significant difference between the two was defined as | PMC10561466 | ||
Results | PMC10561466 | |||
Extraction of features and filtering to create a radiomics model | Of the 4785 radiomics features in the three phases, 2560 had good repeatability (ICC > 0.75), and the dimensionality reduction section was based on these features. A total of 597 features were significantly different by univariate analysis. The six most valuable features were selected from 597 features based on the Gra... | PMC10561466 | ||
The development of nomogram and evaluation of model performance | high-grade | REGRESSION | The clinic-radiological characteristics and Rad-score from the training cohort were subjected to a multivariate logistic regression analysis to obtain a radiomics nomogram score (Nomo-score): Nomo-score= -3.4699 + 0.9858 × Rad-score + 2.1449 × Shape + 2.4012 × REV2 (Fig.
A radiomics nomogram distinguishing between hi... | PMC10561466 |
The correlation between rad-score and the immune microenvironment | We examined the expression pattern and distribution of 12 immune markers in 40 patients with small ccRCC. To investigate the relationship between Rad-score and local immune status, we conducted and correlation analyses (Figure | PMC10561466 | ||
Discussion | tumor, high-grade, kidney tumors, RCC, tumors | TUMOR, TUMORS, KIDNEY TUMORS, RCC | With the increased detection rate of small ccRCC, the frequent underestimation of the histological grade of tumors on puncture biopsy, and the widespread use of active surveillance for patients with small RCC in clinical practice, a reliable method is needed to differentiate the histological grade of small ccRCC. This ... | PMC10561466 |
Conclusion | We have developed and validated a CT-based radiomics nomogram that incorporates a rad-score, shape and REV2 to predict the grading of small ccRCC preoperatively. This nomogram will assist clinicians in making informed diagnostic and treatment decisions. | PMC10561466 | ||
Acknowledgements | Not applicable. | PMC10561466 | ||
Authors’ contributions | YG conceived and wrote the main manuscript text. XW, XZ, CZ and CL collect and process data. JL polished and revised the manuscript. XWu supervised the algorithm development and analyzed the data. All authors read and approved the final manuscript. | PMC10561466 | ||
Funding | This work was supported by 2021 Medical Empowerment- Pilot Elite Research Project Special Fund (NO. XM_HR_YXFN_2021_05_19). | PMC10561466 | ||
Data availability | The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. | PMC10561466 | ||
Declarations | PMC10561466 | |||
Ethic approval and consent to participate | The Ethics Committee of The First Affiliated Hospital of Anhui Medical University approved this retrospective study, and the informed consent was waived. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and /or national research committe... | PMC10561466 | ||
Consent for publication | Not applicable. | PMC10561466 | ||
Competing interests | The authors declare no competing interests. | PMC10561466 | ||
References | PMC10561466 | |||
Objective | LONG COVID | To characterize clinical picture of Long COVID patients and to identify factors associated with quality of life. | PMC10187923 | |
Methods | REGRESSION, SECONDARY, LONG COVID | A secondary data analysis from a randomized clinical trial (RCT) was carried out with 100 Long COVID patients treated by Primary Health Care and residents in the territory of Aragon (northeast of Spain). The main variable of the study was quality of life, evaluated using the SF-36 Questionnaire, in relation to socio-de... | PMC10187923 | |
Results | affective affectation | LONG COVID | Long COVID patients suffer a decrease in their levels of physical and mental health. On the one hand, the higher number of persistent symptoms (b = -0.900, p = 0.008), worse physical functioning (b = 1.587, p = 0.002) and sleep quality (b = -0.538, p = 0.035) are predictors of worse quality of life, physical subscale. ... | PMC10187923 |
Conclusion | It is necessary to design rehabilitation programs that consider both the physical and mental health of these patients, thus obtaining an improvement in their quality of life. | PMC10187923 | ||
Data Availability | The data sets used and/or analyzed during this study are available on the ZENODO platform. They were registered and published on 02/20/2023 with DOI: | PMC10187923 | ||
Introduction | COVID-19 Syndrome, cognitive, functional and social variables, fatigue, musculoskeletal pain | DISEASE, SEQUELAE, LONG COVID | Since the World Health Organization (WHO) declared COVID-19 a highly contagious and harmful pandemic for the human species on March 11, 2020 [Even though most people infected with COVID-19 turn out to be asymptomatic or develop mild-moderate symptoms, it is estimated that around 15% of those affected have progressed to... | PMC10187923 |
Methodology | PMC10187923 | |||
Study design | SECONDARY | This research study is a secondary data analysis [ | PMC10187923 | |
Sample size | The sample size was established in the RCT study, as can be seen in its protocol article [ | PMC10187923 | ||
Recruitment and participants | COVID-19 Syndrome | DISEASE | The study population has been Post COVID-19 Syndrome patients, of legal age (18 years or older) and treated by Primary Health Care. The exclusion criteria put forward for its collection have been: not having a positive diagnostic test for COVID-19 for more than the previous 3 months; have a diagnosis of severe uncontro... | PMC10187923 |
Variables and instruments | myalgia, Gastrointestinal symptoms, fever, cognitive (memory loss, tiredness, spasms, Depression, chills, sore throat, blurred vision, dyspnea, dry, headaches, Anxiety, infections, back pain, hair loss, partial loss of smell or taste, eye problems, fatigue, chest pain, cough, infection, bruising, Insomnia, confusion, t... | SORE THROAT, INFECTIONS, LONG COVID, INFECTION, SECONDARY, HAIR LOSS, CONJUNCTIVITIS, ORTHOSTATIC HYPOTENSION, OVERACTIVE BLADDER, ERECTILE DYSFUNCTION | This study contemplated multiple variables that allow us to know about the Long COVID patient from a broad perspective. For this, in addition to sociodemographic and clinical variables, a total of 10 scales were selected.Socio-demographic variables: gender (man, woman, other), age, civil status (married or in couple/si... | PMC10187923 |
Statistical analysis | REGRESSION, MOS | Statistical analyses were carried out using the IBM SPSS Statistics version 22.0.0.0 and Microsoft Excel computer programs. First, the sample distribution was analyzed, obtaining Shapiro–Wilk statistic values that were lower than 0.05 for all of the variables except for the number of symptoms, SF-36 general health and ... | PMC10187923 | |
Ethics considerations | Ethics approval was granted by the Clinical Research Ethics Committee of Aragon (PI21/139 and PI21/454). The procedures carried out for the creation of this work complied with the ethical standards of the previously mentioned committee and with the 1975 Declaration of Helsinki. All of the subjects signed an informed co... | PMC10187923 | ||
Results | A total of 100 people participated, of which 80 were women and 20 men. The median age was 47 years (IQR 11 years, range: 29–72). | PMC10187923 | ||
Description of sociodemographic and clinical variables of the total sample and comparing by gender. | Delving into the persistent symptoms, as can be observed on | PMC10187923 | ||
Description of persistent symptomatology, frequency and intensity. | Tables | PMC10187923 | ||
Comparation SF-36 physical health score and SF-36 mental health score, according to the gender, marital status, educational level, and employment status. | TWD: temporary work disability. | PMC10187923 | ||
Correlation between SF-36 physical health score and SF-36 mental health score and age, number of persistent symptoms, cognitive and physical functioning, affective state, sleep quality, social support, number of steps walked, and personal construct (self-efficacy, patient´s activation and health literacy). | Depression, Anxiety | REGRESSION | HADS: Hospital Anxiety and Depression Scale, MOS-SS: Medical Outcomes Study Social Support Survey (MOS-SS), IPAQ-SF: International Physical Activity Questionnaire-Short FormRegarding the linear regression model, the results are shown in | PMC10187923 |
Linear regression models in relation to the SF-36 physical and mental health score. | PMC10187923 | |||
Discussion | myalgia, cognitive impairment, fatigue, Memory loss, frustration, infection, tiredness, Confusion | DISEASE, CHRONIC DISEASES, COVID-19 INFECTION, LONG COVID, INFECTION, SECONDARY, REGRESSION | This is an analysis of secondary data from an RCT conducted in Spain with 100 Long COVID patients with a diagnostic test for COVID-19 performed 12 weeks or more ago and regularly attended by primary helth care. In this way, it has been tried to obtain scientific evidence that helps to characterize clinical picture of L... | PMC10187923 |
Limitations and strengths | DISEASE, SECONDARY, PATHOLOGY, LONG COVID | Our study has some limitations. First, although the secondary data analysis of RCTs are a good starting point to know the baseline situations of some investigations [Regarding the strengths, research on the Long COVID disease is scaled up and, particularly, the impact on the quality of life of those affected. For this ... | PMC10187923 | |
Conclusion | cognitive impairment | REGRESSION, LONG COVID | In conclusion, patients diagnosed with Long COVID suffer a decline in their physical and mental health, which are proportionally and significantly correlated with the number of symptoms they present, cognitive impairment, a low affective-emotional state, related problems with their quality sleep and an acceptable level... | PMC10187923 |
Supporting information | PMC10187923 | |||
Frequency and intensity of persistent symptomatology. | Chronicity | (DOCX)Click here for additional data file.The authors would like to thank the Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS, code RD21/0016/0001-Health Institute Carlos III, Spain), the Primary Health Care Research Group of Aragon (GAIAP-B21-20R) of the Department of Science, the Unive... | PMC10187923 | |
References | PMC10187923 | |||
1. Introduction | Obesity, weight loss | OBESITY, BLOOD, PATHOLOGY, BLIND | Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This ... | PMC10180771 |
2. Materials and Methods | PMC10180771 | |||
2.1. Subjects and Ethical Considerations | SECONDARY, INSULIN RESISTANCE, RECRUITMENT | For the present trial, the primary outcome established was a reduction in body weight. Changes in blood lipids, insulin resistance and body fat percentages were established as secondary outcomes. Based on this, the inclusion criteria for the recruitment of volunteers were as follows: men and women between 18 and 60 yea... | PMC10180771 | |
2.2. Food Supplements | Detailed information on the composition of the food supplements has been described elsewhere [ | PMC10180771 | ||
2.3. Study Design | BLIND | The study was a randomised, crossover, three-arm, blind intervention that lasted 8.5 months. After a 2-week run-in, volunteers were randomly allocated to begin consuming GCP, BG or GCP/BG; randomisation was carried out using the MicrosoftAt the beginning and end of each intervention period, volunteers attended the Huma... | PMC10180771 | |
2.4. Analysis of Metabolism Biomarkers | MP, Diabetes | DIABETES | After collecting the blood samples, serum and plasma were obtained by centrifugation at 3000× C-peptide, ghrelin, gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1), leptin, glucagon insulin, plasminogen activator inhibitor (PAI-1), resistin and visfatin concentrations were analysed in plasma using t... | PMC10180771 |
2.5. Statistical Analysis | The sample size was calculated using the G*Power 3.1.9.7 program, considering body weight as the main variable. Assuming a statistical power of 80%, a level of statistical significance of 5%, a two-tailed hypothesis and a standard deviation of 6.5 and aiming to detect a difference of 2.5 kg, the sample size was calcula... | PMC10180771 | ||
3. Results | The participants in the study were 17 men and 12 women with a mean BMI of 30.1 ± 0.6 kg/m | PMC10180771 | ||
3.1. Dietary Intake | The data on macro- and micronutrient intake during the study are shown in | PMC10180771 | ||
3.5. Hepatic Function and Inflammatory Markers | Finally, | PMC10180771 | ||
4. Discussion | cardiometabolic diseases, reduction in blood pressure, TG, weight reduction | CVD, OBESE, INSULIN SENSITIVITY | Changes in dietary habits, such as reducing total energy intake, limiting the consumption of fat- and carbohydrate-rich foods and increasing the consumption of plant-based foods such as vegetables, legumes, fruits and nuts, along with an active lifestyle and regular exercise, are considered the most effective strategie... | PMC10180771 |
5. Conclusions | overweight | OBESE | The regular intake of the studied food supplements containing BG could improve DBP and VLDL-C blood concentrations, which are of interest in cardiovascular health. However, the consumption of GCP, BG and a combination of both bioactive ingredients was not enough to induce significant positive changes in lipid and gluco... | PMC10180771 |
Author Contributions | Conceptualisation, L.B., R.M. and B.S.; methodology, J.G.-C., B.S., R.M., J.L.S.-C., M.A.S. and S.G.-R.; software, J.G.-C., J.L.S.-C., B.S., M.A.S. and S.G.-R.; validation, B.S. and L.B.; formal analysis, J.G.-C., M.A.S. and S.G.-R.; investigation, B.S., R.M. and L.B.; resources, L.B. and R.M.; data curation, J.G.-C., ... | PMC10180771 | ||
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved by the Clinical Research Ethics Committee of Hospital Universitario Puerta de Hierro, Majadahonda in Madrid (Spain), and the Bioethics Subcommittee of Consejo Superior de Investigaciones Científicas (CSIC). The study was registered in C... | PMC10180771 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10180771 | ||
Data Availability Statement | Data may be available from the corresponding author upon request. | PMC10180771 | ||
Conflicts of Interest | The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. | PMC10180771 | ||
References | BLOOD | Study flow diagram (Consolidated Standards of Reporting Trials, CONSORT 2010).Energy, macronutrient and micronutrient intake recorded in 72 h recalls filled in by volunteers at each intervention stage with the food supplements containing green coffee polyphenols (GCP), beta-glucan (BG) and the mixture of GCP/BG.Data ex... | PMC10180771 | |
Objective | The objective was to analyse and compare the formation and quality of the
embryos developed using conventional in vitro fertilization (IVF) and IVC
techniques with an INVOCell™ device. | PMC10712802 | ||
Methods | Two groups were formed, with eight couples in each, one in culture for three
days (D3) and another in culture for five days (D5), using intravaginal
culture technique with an INVOcell device and a conventional in vitro
fertilization technique. | PMC10712802 | ||
Results | Embryo formation in Group D5 showed 46.7% (IVC) and 40% (IVF) of recovered
blastocysts. In the group D5, the conventional IVF, better embryo
development dynamics was observed, with 66% of expanded blastocysts, against
28% in the IVC. Group D3 showed 75% (IVC) and 53% (IVF) of embryo formation.
Embryonic quality in Grou... | PMC10712802 | ||
Conclusions | The results showed that the IVC technique, using the INVOCell™ device,
provided a healthy and balanced environment for the development and
obtaining of quality embryos with three and five days of culture. | PMC10712802 | ||
INTRODUCTION | Infertility | INFERTILITY | Infertility is a public health problem that according to the World Health
Organization (The intravaginal culture (IVC) technique using the INVOCell ™ device has being
offered as a novelty, and has been a topic in clinical discussions, but this
technology is not new (In Brazil, This study aimed to analyse the rate and q... | PMC10712802 |
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