harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.	[ [ "amiodarone", "thyrotoxicosis" ], [ "amiodarone", "AIT" ] ]
When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.	[ [ "fludarabine", "DAT became positive with anti-IgG and anti-C3d antiglobulins" ] ]
Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.	[ [ "cytosine arabinoside", "Peripheral nervous system disturbances" ] ]
A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.	[ [ "amiodarone", "thyrotoxicosis" ] ]
ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.	[ [ "gemtuzumab ozogamicin", "ARDS" ], [ "OKT3", "ARDS" ], [ "infliximab", "ARDS" ] ]
A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.	[ [ "MTX", "overwhelming hepatic necrosis" ] ]
Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.	[ [ "Ifosfamide", "tubulopathies" ] ]
We report a case of a scleroderma-like reaction induced by long-term administration of UFT.	[ [ "UFT", "scleroderma-like reaction" ] ]
Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.	[ [ "vigabatrin", "visual field constriction" ] ]
Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.	[ [ "omeprazole", "Esophageal candidiasis" ] ]
Clozapine-induced akathisia in children with schizophrenia.	[ [ "Clozapine", "akathisia" ] ]
We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.	[ [ "diphenhydramine", "drug-seeking behavior" ], [ "diphenhydramine", "anticholinergic symptoms" ] ]
Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.	[ [ "rifampicin", "Renal failure" ] ]
The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.	[ [ "vancomycin", "vasculitis" ], [ "vancomycin", "lupus-like syndrome" ] ]
These results indicate that lithium may cause biochemical hyperparathyroidism.	[ [ "lithium", "biochemical hyperparathyroidism" ] ]
We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.	[ [ "heparin", "thrombocytopenia" ] ]
Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.	[ [ "interferon-gamma", "systemic lupus erythematosus" ] ]
Visual hallucinations associated with zonisamide.	[ [ "zonisamide", "Visual hallucinations" ] ]
The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.	[ [ "ritonavir", "carbamazepine toxicity" ], [ "carbamazepine", "carbamazepine toxicity" ] ]
Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.	[ [ "carboplatin", "Hypersensitivity" ], [ "carboplatin", "hyperacute changes on ECG" ] ]
Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.	[ [ "acyclovir", "pleural friction rub" ], [ "acyclovir", "fever" ], [ "acyclovir", "hemoptysis" ] ]
This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.	[ [ "calcitriol", "milk-alkali syndrome" ], [ "calcium carbonate", "milk-alkali syndrome" ] ]
Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.	[ [ "recombinant alpha interferon", "Sustained hypothyroidism" ] ]
MR findings in methotrexate-induced CNS abnormalities.	[ [ "methotrexate", "CNS abnormalities" ] ]
We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.	[ [ "voglibose", "vomiting" ], [ "voglibose", "nausea" ], [ "voglibose", "intolerable dizziness" ] ]
Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.	[ [ "phenolphthalein", "TEN" ] ]
Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.	[ [ "dapsone", "minor neurological and gastrointestinal complaints" ], [ "dapsone", "severe hypoalbuminemia without proteinuria" ], [ "dapsone", "toxic hepatitis" ], [ "dapsone", "leukopenia" ], [ "dapsone", "peripheral neuropathy" ], [ "dapsone", "cutaneous eruptions" ], [ "dapsone", "an infectious mononucleosis-like syndrome" ], [ "dapsone", "agranulocytosis" ], [ "dapsone", "nephrotic syndrome" ], [ "dapsone", "psychosis" ], [ "dapsone", "renal papillary necrosis" ], [ "dapsone", "cholestatic jaundice" ] ]
We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.	[ [ "gold", "bilateral interstitial pulmonary abnormalities" ] ]
Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.	[ [ "tranexamic acid", "Polymyoclonus seizure" ] ]
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.	[ [ "methotrexate", "Transient neurological disturbances" ] ]
This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.	[ [ "5-ASA", "sensorimotor polyneuropathy" ] ]
Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.	[ [ "methadone", "fluctuation of the QT interval" ] ]
Hepatotoxicity of hycanthone in patients with metastatic breast cancer.	[ [ "hycanthone", "Hepatotoxicity" ] ]
Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.	[ [ "doxorubicin", "Severe acute encephalopathy" ] ]
The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced "jitteriness" may be identical.	[ [ "fluoxetine", "akathisia" ] ]
CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.	[ [ "erlotinib", "acute severe hepatitis" ] ]
Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.	[ [ "nevirapine", "Stevens-Johnson syndrome" ], [ "nevirapine", "SJS" ], [ "nevirapine", "Severe rash" ] ]
Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.	[ [ "foscarnet", "renal tubular acidosis" ], [ "foscarnet", "Nephrogenic diabetes insipidus" ] ]
Focal renal cortical necrosis associated with zomepirac.	[ [ "zomepirac", "Focal renal cortical necrosis" ] ]
INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.	[ [ "fluticasone propionate", "growth may be retarded" ], [ "fluticasone propionate", "adrenal suppression" ] ]
Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature.	[ [ "MTX", "cirrhosis" ], [ "MTX", "liver cirrhosis" ] ]
We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.	[ [ "salazosulfapyridine", "acute generalized exanthematous pustulosis" ] ]
The pulmonary toxicity is probably induced by piritrexim.	[ [ "piritrexim", "pulmonary toxicity" ] ]
We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.	[ [ "captopril", "neutropenia" ] ]
This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.	[ [ "clozapine", "elevated serum triglyceride levels" ] ]
Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.	[ [ "Teicoplanin", "agranulocytosis" ], [ "vancomycin", "agranulocytosis" ] ]
Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.	[ [ "Ticlopidine", "TIAA" ], [ "Ticlopidine", "aplastic anemia" ] ]
Acyclovir neurotoxicity: clinical experience and review of the literature.	[ [ "Acyclovir", "neurotoxicity" ] ]
CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.	[ [ "desferrioxamine", "unilateral hearing loss" ] ]
Flurbiprofen-associated acute tubulointerstitial nephritis.	[ [ "Flurbiprofen", "acute tubulointerstitial nephritis" ] ]
She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.	[ [ "verapamil", "asthma" ] ]
Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.	[ [ "cyclosporine", "rhabdomyolysis" ], [ "Simvastatin", "rhabdomyolysis" ] ]
We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.	[ [ "etanercept", "persistent hypoglycemia" ] ]
PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.	[ [ "carbamazepine", "hyperammonemia" ] ]
A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.	[ [ "calcium hopantenate", "acute encephalopathy" ] ]
A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.	[ [ "vancomycin", "tender erythematous" ], [ "vancomycin", "hemorrhagic lesions of the finger tips" ], [ "vancomycin", "lupus-like syndrome" ], [ "vancomycin", "pain" ], [ "vancomycin", "malar rash" ], [ "vancomycin", "erythema of the cartilage of both ears" ] ]
We present three patients with paradoxical seizures; their serum phenytoin levels were 43.5 mcg/mL, 46.5 mcg/mL and 38.3 mcg/mL.	[ [ "phenytoin", "seizures" ] ]
Panic anxiety after abrupt discontinuation of mianserin.	[ [ "mianserin", "Panic anxiety" ] ]
Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.	[ [ "L-asparaginase", "pseudocyst of the pancreas" ] ]
Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.	[ [ "2-CdA", "transformation of MCD to NHL" ] ]
To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.	[ [ "2-chlorodeoxyadenosine", "AML" ] ]
Tardive dyskinesia induced by sulpiride.	[ [ "sulpiride", "Tardive dyskinesia" ] ]
Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.	[ [ "Depo-Medrol", "ossification of the spinal arachnoid" ], [ "Depo-Medrol", "Calcification" ] ]
In all the patients, pellagra symptoms appeared during isoniazid therapy.	[ [ "isoniazid", "pellagra" ] ]
Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.	[ [ "taxol", "peripheral neuropathy" ] ]
The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.	[ [ "penicillin", "worsening headache" ], [ "penicillin", "feeling cold" ], [ "penicillin", "chills" ] ]
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.	[ [ "methylprednisolone", "Acute myopathy" ], [ "vecuronium", "degeneration of myosin filaments" ], [ "methylprednisolone", "degeneration of myosin filaments" ], [ "vecuronium", "Acute myopathy" ] ]
Life-threatening cranial dystonia following trihexyphenidyl withdrawal.	[ [ "trihexyphenidyl", "cranial dystonia" ] ]
Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.	[ [ "interferon alpha", "Polymyositis" ] ]
Esophageal candidiasis following omeprazole therapy: a report of two cases.	[ [ "omeprazole", "Esophageal candidiasis" ] ]
A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.	[ [ "D-penicillamine", "rapidly progressive glomerulonephritis" ], [ "D-penicillamine", "epithelial crescents" ], [ "D-penicillamine", "hemoptysis" ] ]
However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.	[ [ "mequitazine", "photosensitivity" ] ]
This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.	[ [ "sulfadiazine", "hypersensitivity" ] ]
After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.	[ [ "methylprednisolone", "psychotic reaction" ] ]
Juvenile absence epilepsy exacerbated by valproic acid.	[ [ "valproic acid", "Juvenile absence epilepsy" ] ]
Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.	[ [ "methotrexate", "nodules" ] ]
Phenytoin-induced hypersensitivity reactions.	[ [ "Phenytoin", "hypersensitivity reactions" ] ]
In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.	[ [ "INH", "seizures" ] ]
Bromocriptine-induced schizophrenia.	[ [ "Bromocriptine", "schizophrenia" ] ]
Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.	[ [ "AZA", "allergic skin eruptions" ] ]
Supravenous hyperpigmentation in association with CHOP chemotherapy of a CD30 (Ki-1)-positive anaplastic large-cell lymphoma.	[ [ "CHOP", "Supravenous hyperpigmentation" ] ]
A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.	[ [ "propranolol", "esophageal spasm" ] ]
Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.	[ [ "Colchicine", "rhabdomyolysis" ] ]
The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.	[ [ "DCF", "keratitis" ], [ "DCF", "conjunctivitis" ], [ "DCF", "ocular toxicity" ] ]
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.	[ [ "LTG", "encephalopathy" ] ]
BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.	[ [ "Cyanamide", "hepatic lesion with ground-glass inclusion bodies" ] ]
A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.	[ [ "interferon (IFN)-beta", "proteinuria" ] ]
He was later skin tested to confirm allergy to MTX.	[ [ "MTX", "allergy" ] ]
Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.	[ [ "cyclophosphamide", "abdominal right lower quadrant pain" ], [ "cyclophosphamide", "cecal lymphoma" ] ]
However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.	[ [ "warfarin", "increase in INR" ], [ "5-FU", "increase in INR" ] ]
After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.	[ [ "interferon alpha", "neurological manifestations" ] ]
Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.	[ [ "cephalosporin", "Coagulopathy" ], [ "moxalactam", "Coagulopathy" ] ]
Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.	[ [ "prednisone", "Severe hyperkalemia" ] ]
Amiodarone induced torsades de pointe.	[ [ "Amiodarone", "torsades de pointe" ] ]
INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.	[ [ "sodium valproic acid", "raised intracranial pressure" ], [ "VPA", "raised intracranial pressure" ], [ "VPA", "severe cerebral swelling" ], [ "sodium valproic acid", "severe cerebral swelling" ] ]
Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.	[ [ "gemcitabine", "hemolytic uremic syndrome" ] ]
Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.	[ [ "sodium phosphate", "hyperphosphatemia" ] ]
The increased libido disappeared after fluvoxamine was discontinued.	[ [ "fluvoxamine", "increased libido" ] ]
This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.	[ [ "BH-AC", "encephalopathy syndrome" ] ]
Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.	[ [ "sumatriptan", "symptomatic cerebral vasospasm" ] ]

Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.

[ [ "amiodarone", "thyrotoxicosis" ], [ "amiodarone", "AIT" ] ]

When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.

[ [ "fludarabine", "DAT became positive with anti-IgG and anti-C3d antiglobulins" ] ]

Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.

[ [ "cytosine arabinoside", "Peripheral nervous system disturbances" ] ]

A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.

[ [ "amiodarone", "thyrotoxicosis" ] ]

ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.

[ [ "gemtuzumab ozogamicin", "ARDS" ], [ "OKT3", "ARDS" ], [ "infliximab", "ARDS" ] ]

A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.

[ [ "MTX", "overwhelming hepatic necrosis" ] ]

Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.

[ [ "Ifosfamide", "tubulopathies" ] ]

We report a case of a scleroderma-like reaction induced by long-term administration of UFT.

[ [ "UFT", "scleroderma-like reaction" ] ]

Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.

[ [ "vigabatrin", "visual field constriction" ] ]

Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.

[ [ "omeprazole", "Esophageal candidiasis" ] ]

Clozapine-induced akathisia in children with schizophrenia.

[ [ "Clozapine", "akathisia" ] ]

We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.

[ [ "diphenhydramine", "drug-seeking behavior" ], [ "diphenhydramine", "anticholinergic symptoms" ] ]

Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.

[ [ "rifampicin", "Renal failure" ] ]

The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.

[ [ "vancomycin", "vasculitis" ], [ "vancomycin", "lupus-like syndrome" ] ]

These results indicate that lithium may cause biochemical hyperparathyroidism.

[ [ "lithium", "biochemical hyperparathyroidism" ] ]

We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.

[ [ "heparin", "thrombocytopenia" ] ]

Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.

[ [ "interferon-gamma", "systemic lupus erythematosus" ] ]

Visual hallucinations associated with zonisamide.

[ [ "zonisamide", "Visual hallucinations" ] ]

The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.

[ [ "ritonavir", "carbamazepine toxicity" ], [ "carbamazepine", "carbamazepine toxicity" ] ]

Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.

[ [ "carboplatin", "Hypersensitivity" ], [ "carboplatin", "hyperacute changes on ECG" ] ]

Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.

[ [ "acyclovir", "pleural friction rub" ], [ "acyclovir", "fever" ], [ "acyclovir", "hemoptysis" ] ]

This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.

[ [ "calcitriol", "milk-alkali syndrome" ], [ "calcium carbonate", "milk-alkali syndrome" ] ]

Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.

[ [ "recombinant alpha interferon", "Sustained hypothyroidism" ] ]

MR findings in methotrexate-induced CNS abnormalities.

[ [ "methotrexate", "CNS abnormalities" ] ]

We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.

[ [ "voglibose", "vomiting" ], [ "voglibose", "nausea" ], [ "voglibose", "intolerable dizziness" ] ]

Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.

[ [ "phenolphthalein", "TEN" ] ]

Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.

[ [ "dapsone", "minor neurological and gastrointestinal complaints" ], [ "dapsone", "severe hypoalbuminemia without proteinuria" ], [ "dapsone", "toxic hepatitis" ], [ "dapsone", "leukopenia" ], [ "dapsone", "peripheral neuropathy" ], [ "dapsone", "cutaneous eruptions" ], [ "dapsone", "an infectious mononucleosis-like syndrome" ], [ "dapsone", "agranulocytosis" ], [ "dapsone", "nephrotic syndrome" ], [ "dapsone", "psychosis" ], [ "dapsone", "renal papillary necrosis" ], [ "dapsone", "cholestatic jaundice" ] ]

We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.

[ [ "gold", "bilateral interstitial pulmonary abnormalities" ] ]

Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.

[ [ "tranexamic acid", "Polymyoclonus seizure" ] ]

Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.

[ [ "methotrexate", "Transient neurological disturbances" ] ]

This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.

[ [ "5-ASA", "sensorimotor polyneuropathy" ] ]

Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.

[ [ "methadone", "fluctuation of the QT interval" ] ]

Hepatotoxicity of hycanthone in patients with metastatic breast cancer.

[ [ "hycanthone", "Hepatotoxicity" ] ]

Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.

[ [ "doxorubicin", "Severe acute encephalopathy" ] ]

The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced "jitteriness" may be identical.

[ [ "fluoxetine", "akathisia" ] ]

CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.

[ [ "erlotinib", "acute severe hepatitis" ] ]

Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.

[ [ "nevirapine", "Stevens-Johnson syndrome" ], [ "nevirapine", "SJS" ], [ "nevirapine", "Severe rash" ] ]

Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.

[ [ "foscarnet", "renal tubular acidosis" ], [ "foscarnet", "Nephrogenic diabetes insipidus" ] ]

Focal renal cortical necrosis associated with zomepirac.

[ [ "zomepirac", "Focal renal cortical necrosis" ] ]

INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.

[ [ "fluticasone propionate", "growth may be retarded" ], [ "fluticasone propionate", "adrenal suppression" ] ]

Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature.

[ [ "MTX", "cirrhosis" ], [ "MTX", "liver cirrhosis" ] ]

We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.

[ [ "salazosulfapyridine", "acute generalized exanthematous pustulosis" ] ]

The pulmonary toxicity is probably induced by piritrexim.

[ [ "piritrexim", "pulmonary toxicity" ] ]

We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.

[ [ "captopril", "neutropenia" ] ]

This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.

[ [ "clozapine", "elevated serum triglyceride levels" ] ]

Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.

[ [ "Teicoplanin", "agranulocytosis" ], [ "vancomycin", "agranulocytosis" ] ]

Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.

[ [ "Ticlopidine", "TIAA" ], [ "Ticlopidine", "aplastic anemia" ] ]

Acyclovir neurotoxicity: clinical experience and review of the literature.

[ [ "Acyclovir", "neurotoxicity" ] ]

CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.

[ [ "desferrioxamine", "unilateral hearing loss" ] ]

Flurbiprofen-associated acute tubulointerstitial nephritis.

[ [ "Flurbiprofen", "acute tubulointerstitial nephritis" ] ]

She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.

[ [ "verapamil", "asthma" ] ]

Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.

[ [ "cyclosporine", "rhabdomyolysis" ], [ "Simvastatin", "rhabdomyolysis" ] ]

We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.

[ [ "etanercept", "persistent hypoglycemia" ] ]

PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.

[ [ "carbamazepine", "hyperammonemia" ] ]

A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.

[ [ "calcium hopantenate", "acute encephalopathy" ] ]

A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.

[ [ "vancomycin", "tender erythematous" ], [ "vancomycin", "hemorrhagic lesions of the finger tips" ], [ "vancomycin", "lupus-like syndrome" ], [ "vancomycin", "pain" ], [ "vancomycin", "malar rash" ], [ "vancomycin", "erythema of the cartilage of both ears" ] ]

We present three patients with paradoxical seizures; their serum phenytoin levels were 43.5 mcg/mL, 46.5 mcg/mL and 38.3 mcg/mL.

[ [ "phenytoin", "seizures" ] ]

Panic anxiety after abrupt discontinuation of mianserin.

[ [ "mianserin", "Panic anxiety" ] ]

Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.

[ [ "L-asparaginase", "pseudocyst of the pancreas" ] ]

Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.

[ [ "2-CdA", "transformation of MCD to NHL" ] ]

To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.

[ [ "2-chlorodeoxyadenosine", "AML" ] ]

Tardive dyskinesia induced by sulpiride.

[ [ "sulpiride", "Tardive dyskinesia" ] ]

Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.

[ [ "Depo-Medrol", "ossification of the spinal arachnoid" ], [ "Depo-Medrol", "Calcification" ] ]

In all the patients, pellagra symptoms appeared during isoniazid therapy.

[ [ "isoniazid", "pellagra" ] ]

Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.

[ [ "taxol", "peripheral neuropathy" ] ]

The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.

[ [ "penicillin", "worsening headache" ], [ "penicillin", "feeling cold" ], [ "penicillin", "chills" ] ]

Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.

[ [ "methylprednisolone", "Acute myopathy" ], [ "vecuronium", "degeneration of myosin filaments" ], [ "methylprednisolone", "degeneration of myosin filaments" ], [ "vecuronium", "Acute myopathy" ] ]

Life-threatening cranial dystonia following trihexyphenidyl withdrawal.

[ [ "trihexyphenidyl", "cranial dystonia" ] ]

Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.

[ [ "interferon alpha", "Polymyositis" ] ]

Esophageal candidiasis following omeprazole therapy: a report of two cases.

[ [ "omeprazole", "Esophageal candidiasis" ] ]

A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.

[ [ "D-penicillamine", "rapidly progressive glomerulonephritis" ], [ "D-penicillamine", "epithelial crescents" ], [ "D-penicillamine", "hemoptysis" ] ]

However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.

[ [ "mequitazine", "photosensitivity" ] ]

This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.

[ [ "sulfadiazine", "hypersensitivity" ] ]

After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.

[ [ "methylprednisolone", "psychotic reaction" ] ]

Juvenile absence epilepsy exacerbated by valproic acid.

[ [ "valproic acid", "Juvenile absence epilepsy" ] ]

Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.

[ [ "methotrexate", "nodules" ] ]

Phenytoin-induced hypersensitivity reactions.

[ [ "Phenytoin", "hypersensitivity reactions" ] ]

In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.

[ [ "INH", "seizures" ] ]

Bromocriptine-induced schizophrenia.

[ [ "Bromocriptine", "schizophrenia" ] ]

Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.

[ [ "AZA", "allergic skin eruptions" ] ]

Supravenous hyperpigmentation in association with CHOP chemotherapy of a CD30 (Ki-1)-positive anaplastic large-cell lymphoma.

[ [ "CHOP", "Supravenous hyperpigmentation" ] ]

A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.

[ [ "propranolol", "esophageal spasm" ] ]

Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.

[ [ "Colchicine", "rhabdomyolysis" ] ]

The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.

[ [ "DCF", "keratitis" ], [ "DCF", "conjunctivitis" ], [ "DCF", "ocular toxicity" ] ]

CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.

[ [ "LTG", "encephalopathy" ] ]

BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.

[ [ "Cyanamide", "hepatic lesion with ground-glass inclusion bodies" ] ]

A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.

[ [ "interferon (IFN)-beta", "proteinuria" ] ]

He was later skin tested to confirm allergy to MTX.

[ [ "MTX", "allergy" ] ]

Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.

[ [ "cyclophosphamide", "abdominal right lower quadrant pain" ], [ "cyclophosphamide", "cecal lymphoma" ] ]

However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.

[ [ "warfarin", "increase in INR" ], [ "5-FU", "increase in INR" ] ]

After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.

[ [ "interferon alpha", "neurological manifestations" ] ]

Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.

[ [ "cephalosporin", "Coagulopathy" ], [ "moxalactam", "Coagulopathy" ] ]

Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.

[ [ "prednisone", "Severe hyperkalemia" ] ]

Amiodarone induced torsades de pointe.

[ [ "Amiodarone", "torsades de pointe" ] ]

INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.

[ [ "sodium valproic acid", "raised intracranial pressure" ], [ "VPA", "raised intracranial pressure" ], [ "VPA", "severe cerebral swelling" ], [ "sodium valproic acid", "severe cerebral swelling" ] ]

Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.

[ [ "gemcitabine", "hemolytic uremic syndrome" ] ]

Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.

[ [ "sodium phosphate", "hyperphosphatemia" ] ]

The increased libido disappeared after fluvoxamine was discontinued.

[ [ "fluvoxamine", "increased libido" ] ]

This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.

[ [ "BH-AC", "encephalopathy syndrome" ] ]

Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.

[ [ "sumatriptan", "symptomatic cerebral vasospasm" ] ]