harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
The course of delirium due to lithium intoxication.	[ [ "lithium", "delirium" ] ]
Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.	[ [ "Zephiran", "circumoral and pharyngeal burns" ], [ "benzalkonium", "circumoral and pharyngeal burns" ] ]
Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.	[ [ "lithium", "CDI" ] ]
Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.	[ [ "dexamethasone", "osteonecrosis" ] ]
CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.	[ [ "moxifloxacin", "corneal ulcers" ] ]
We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.	[ [ "tegaserod", "ischemic colitis" ], [ "tegaserod", "irritable bowel syndrome" ] ]
Refractory hypoglycemia from ciprofloxacin and glyburide interaction.	[ [ "ciprofloxacin", "Refractory hypoglycemia" ], [ "glyburide", "Refractory hypoglycemia" ] ]
Clofazimine enteropathy in a pediatric bone marrow transplant recipient.	[ [ "Clofazimine", "enteropathy" ] ]
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.	[ [ "Interferon-alpha", "hyperthyroidism" ] ]
CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.	[ [ "levothyroxine", "increased serum thyroid-stimulating hormone" ] ]
Quinine-induced hearing loss.	[ [ "Quinine", "hearing loss" ] ]
Quetiapine-induced leucopenia and thrombocytopenia.	[ [ "Quetiapine", "leucopenia" ], [ "Quetiapine", "thrombocytopenia" ] ]
Dermatitis to captopril.	[ [ "captopril", "Dermatitis" ] ]
We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.	[ [ "vaccination against hepatitis B", "polyarteritis nodosa" ] ]
When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.	[ [ "ticlopidine", "cytotoxic effect" ] ]
Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.	[ [ "ofloxacin", "neurotoxic effects" ] ]
Intravenous diazepam exacerbated the seizures.	[ [ "diazepam", "seizures" ] ]
Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.	[ [ "Sertraline", "rhabdomyolysis" ] ]
The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.	[ [ "bisphosphonate", "osteonecrosis of the mandible" ] ]
Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.	[ [ "aspirin", "asthma" ] ]
Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.	[ [ "metronidazole", "pseudomembranous colitis" ] ]
During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.	[ [ "omeprazole", "peripheral edema" ], [ "pantoprazole", "peripheral edema" ] ]
The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.	[ [ "ticlopidine", "aplastic anemia" ] ]
We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.	[ [ "haloperidol", "WES" ] ]
However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.	[ [ "halofantrine", "cardiac effects" ], [ "halofantrine", "sudden death" ] ]
OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.	[ [ "valproic acid", "mania" ], [ "VPA", "mania" ], [ "ritonavir", "mania" ], [ "lopinavir", "mania" ] ]
Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.	[ [ "Cisplatin", "syndrome of inappropriate antidiuretic hormone" ], [ "Cisplatin", "SIADH" ] ]
We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.	[ [ "infliximab", "lymphoma" ] ]
Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.	[ [ "verapamil", "Cardiac decompensation" ] ]
Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.	[ [ "heroin", "ballistic movements" ] ]
Metastatic osteomyelitis following BCG vaccination.	[ [ "BCG", "Metastatic osteomyelitis" ] ]
We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.	[ [ "cyproterone acetate", "femoral head avascular necrosis" ] ]
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.	[ [ "PTU", "antineutrophil cytoplasmic antibody" ], [ "propylthiouracil", "antineutrophil cytoplasmic antibody" ] ]
The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.	[ [ "niacin", "visual symptoms" ] ]
Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.	[ [ "all-trans-retinoic acid", "Acute neutrophilic dermatosis" ] ]
We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.	[ [ "interferon", "Graves' hyperthyroidism" ], [ "IFN", "Graves' hyperthyroidism" ] ]
PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.	[ [ "amantadine", "bilateral corneal endothelial dysfunction" ] ]
The possibility of deep vein thrombosis caused by the compression of the veins by necrotic tumor should be considered in patients with abdominal or pelvic metastases of GIST, including patients treated with imatinib.	[ [ "imatinib", "deep vein thrombosis" ] ]
A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).	[ [ "fludarabine", "fever" ], [ "fludarabine", "cough" ] ]
Neonatal mydriasis: intravenous lidocaine adverse reaction.	[ [ "lidocaine", "mydriasis" ] ]
Livedo reticularis associated with interferon alpha therapy in two melanoma patients.	[ [ "interferon alpha", "Livedo reticularis" ] ]
However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.	[ [ "clofibrate", "myopathy" ] ]
Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.	[ [ "adrenocorticotropic hormone", "Hyperkalemia" ] ]
This is the first reported case of suspected DIAN due to cefuroxime.	[ [ "cefuroxime", "DIAN" ] ]
A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).	[ [ "methotrexate", "ascites" ], [ "MTX", "ascites" ] ]
In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.	[ [ "spironolactone", "serious and, occasionally, fatal hyperkalaemia" ] ]
We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.	[ [ "PTU", "fulminant hepatitis" ] ]
In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.	[ [ "promethazine", "persistence of the photosensitivity" ], [ "promethazine", "cross-reaction to promethazine" ], [ "promethazine", "erythema" ], [ "mequitazine", "cross-reaction to promethazine" ], [ "mequitazine", "persistence of the photosensitivity" ], [ "mequitazine", "erythema" ], [ "mequitazine", "decreased MED to both UVA and UVB" ], [ "promethazine", "decreased MED to both UVA and UVB" ] ]
Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.	[ [ "Torsemide", "pancreatitis" ] ]
Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.	[ [ "imatinib", "blast crisis" ] ]
The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.	[ [ "5-fluorouracil", "cardiotoxicity" ], [ "5-FU", "cardiotoxicity" ] ]
OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.	[ [ "ofloxacin", "toxic epidermal necrolysis" ] ]
Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.	[ [ "warfarin", "haematoma" ], [ "warfarin", "discomfort" ], [ "warfarin", "diplopia" ], [ "warfarin", "lagophthalmos" ] ]
Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.	[ [ "DGTX", "cardiac DGTX toxicity" ], [ "DGTX", "total AV-block" ] ]
These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.	[ [ "aspirin", "RS" ] ]
Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.	[ [ "cefoxitin sodium", "acute deterioration of renal function" ] ]
A paradoxical ocular effect of brimonidine.	[ [ "brimonidine", "paradoxical ocular effect" ] ]
Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.	[ [ "heparin", "thrombocytopenia" ] ]
We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.	[ [ "prednisolone", "SJS" ] ]
Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.	[ [ "Procainamide", "incessant supraventricular tachycardia" ] ]
After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.	[ [ "Partusisten", "supraventricular tachycardia" ] ]
Severe abdominal pain in low dosage clofazimine.	[ [ "clofazimine", "abdominal pain" ] ]
PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.	[ [ "clomiphene citrate", "bilateral anterior uveitis" ] ]
Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".	[ [ "retinoic acid", "retinoic acid syndrome" ], [ "retinoic acid", "fatal complication" ] ]
Two patients are described who developed testicular swelling and pain during treatment with desipramine.	[ [ "desipramine", "testicular swelling" ], [ "desipramine", "pain" ] ]
Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.	[ [ "Treosulfan", "Acute non-lymphocytic leukemia" ], [ "dihydroxybusulfan", "Acute non-lymphocytic leukemia" ] ]
Isoniazid causing breast tissue enlargement has been very rarely reported.	[ [ "Isoniazid", "breast tissue enlargement" ] ]
It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.	[ [ "lead", "hypertension" ], [ "lead", "lead-induced hypertension" ] ]
Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.	[ [ "thrombin", "severe arterial thrombotic events" ] ]
One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.	[ [ "olanzapine", "extrapyramidal side effects" ] ]
We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.	[ [ "ethanol", "subcutaneous metastasis" ] ]
After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.	[ [ "ethambutol", "rash" ], [ "ethambutol", "polyarthritis" ], [ "ethambutol", "hepatitis" ], [ "ethambutol", "anti-native DNA antibodies" ] ]
Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.	[ [ "vitamin D", "hypercalcemia" ], [ "vitamin D", "acute vitamin D poisoning" ] ]
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.	[ [ "fludarabine", "AML" ], [ "fludarabine", "lung cancer" ] ]
We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.	[ [ "gold", "respiratory failure" ] ]
Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.	[ [ "Propoxyphene", "wide QRS complex dysrhythmia" ] ]
Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.	[ [ "flutamide", "flutamide withdrawal syndrome" ], [ "flutamide", "Prolonged prostate-specific antigen response" ] ]
Ceftriaxone-induced fixed drug eruption: first report.	[ [ "Ceftriaxone", "fixed drug eruption" ] ]
PURPOSE: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity.	[ [ "hydroxychloroquine", "retinal toxicity" ] ]
A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.	[ [ "paclitaxel", "disabling neurotoxicity" ] ]
A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.	[ [ "methimazole", "agranulocytosis" ] ]
She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.	[ [ "metoclopramide", "dysarthria" ], [ "metoclopramide", "movement disorder" ], [ "metoclopramide", "agitation" ], [ "metoclopramide", "diaphoresis" ] ]
This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.	[ [ "erlotinib", "ILD" ] ]
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.	[ [ "valproic acid", "coma" ] ]
2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.	[ [ "2-Chloro-deoxyadenosine", "non-Hodgkin's lymphoma" ] ]
Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.	[ [ "propranolol", "bronchospasm" ] ]
Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.	[ [ "carbamazepine", "SLE" ] ]
Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.	[ [ "alteplase", "Massive subfascial hematoma" ] ]
Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.	[ [ "interferon-beta", "bursitis" ], [ "interferon-beta", "Arthritis" ] ]
PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.	[ [ "interferon alfa", "sudden bilateral, sequential visual loss" ] ]
These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.	[ [ "propylthiouracil", "hepatic injury" ], [ "propylthiouracil", "submassive hepatic necrosis" ] ]
According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.	[ [ "enoxaparin", "hepatotoxicity" ] ]
Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.	[ [ "imatinib", "tumor lysis syndrome" ] ]
Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.	[ [ "arginine monohydrochloride", "Marked hyperkalemia" ] ]
DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.	[ [ "Olanzapine", "muscle injury with concomitant elevations of serum CK" ] ]
The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).	[ [ "lithium", "neurotoxicity" ] ]
Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.	[ [ "pentamidine", "cardiotoxicity" ], [ "pentamidine", "second-degree heart block" ] ]
Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.	[ [ "INH", "neurotoxicity" ] ]
We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.	[ [ "celiprolol", "hypersensitivity pneumonitis" ] ]
Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.	[ [ "amiodarone", "pancreatitis" ], [ "amiodarone", "Pancreatitis" ] ]

The course of delirium due to lithium intoxication.

[ [ "lithium", "delirium" ] ]

Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.

[ [ "Zephiran", "circumoral and pharyngeal burns" ], [ "benzalkonium", "circumoral and pharyngeal burns" ] ]

Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.

[ [ "lithium", "CDI" ] ]

Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.

[ [ "dexamethasone", "osteonecrosis" ] ]

CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.

[ [ "moxifloxacin", "corneal ulcers" ] ]

We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.

[ [ "tegaserod", "ischemic colitis" ], [ "tegaserod", "irritable bowel syndrome" ] ]

Refractory hypoglycemia from ciprofloxacin and glyburide interaction.

[ [ "ciprofloxacin", "Refractory hypoglycemia" ], [ "glyburide", "Refractory hypoglycemia" ] ]

Clofazimine enteropathy in a pediatric bone marrow transplant recipient.

[ [ "Clofazimine", "enteropathy" ] ]

Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.

[ [ "Interferon-alpha", "hyperthyroidism" ] ]

CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.

[ [ "levothyroxine", "increased serum thyroid-stimulating hormone" ] ]

Quinine-induced hearing loss.

[ [ "Quinine", "hearing loss" ] ]

Quetiapine-induced leucopenia and thrombocytopenia.

[ [ "Quetiapine", "leucopenia" ], [ "Quetiapine", "thrombocytopenia" ] ]

Dermatitis to captopril.

[ [ "captopril", "Dermatitis" ] ]

We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.

[ [ "vaccination against hepatitis B", "polyarteritis nodosa" ] ]

When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.

[ [ "ticlopidine", "cytotoxic effect" ] ]

Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.

[ [ "ofloxacin", "neurotoxic effects" ] ]

Intravenous diazepam exacerbated the seizures.

[ [ "diazepam", "seizures" ] ]

Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

[ [ "Sertraline", "rhabdomyolysis" ] ]

The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.

[ [ "bisphosphonate", "osteonecrosis of the mandible" ] ]

Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.

[ [ "aspirin", "asthma" ] ]

Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.

[ [ "metronidazole", "pseudomembranous colitis" ] ]

During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.

[ [ "omeprazole", "peripheral edema" ], [ "pantoprazole", "peripheral edema" ] ]

The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.

[ [ "ticlopidine", "aplastic anemia" ] ]

We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.

[ [ "haloperidol", "WES" ] ]

However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.

[ [ "halofantrine", "cardiac effects" ], [ "halofantrine", "sudden death" ] ]

OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.

[ [ "valproic acid", "mania" ], [ "VPA", "mania" ], [ "ritonavir", "mania" ], [ "lopinavir", "mania" ] ]

Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.

[ [ "Cisplatin", "syndrome of inappropriate antidiuretic hormone" ], [ "Cisplatin", "SIADH" ] ]

We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.

[ [ "infliximab", "lymphoma" ] ]

Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.

[ [ "verapamil", "Cardiac decompensation" ] ]

Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.

[ [ "heroin", "ballistic movements" ] ]

Metastatic osteomyelitis following BCG vaccination.

[ [ "BCG", "Metastatic osteomyelitis" ] ]

We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.

[ [ "cyproterone acetate", "femoral head avascular necrosis" ] ]

A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.

[ [ "PTU", "antineutrophil cytoplasmic antibody" ], [ "propylthiouracil", "antineutrophil cytoplasmic antibody" ] ]

The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.

[ [ "niacin", "visual symptoms" ] ]

Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.

[ [ "all-trans-retinoic acid", "Acute neutrophilic dermatosis" ] ]

We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.

[ [ "interferon", "Graves' hyperthyroidism" ], [ "IFN", "Graves' hyperthyroidism" ] ]

PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.

[ [ "amantadine", "bilateral corneal endothelial dysfunction" ] ]

The possibility of deep vein thrombosis caused by the compression of the veins by necrotic tumor should be considered in patients with abdominal or pelvic metastases of GIST, including patients treated with imatinib.

[ [ "imatinib", "deep vein thrombosis" ] ]

A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).

[ [ "fludarabine", "fever" ], [ "fludarabine", "cough" ] ]

Neonatal mydriasis: intravenous lidocaine adverse reaction.

[ [ "lidocaine", "mydriasis" ] ]

Livedo reticularis associated with interferon alpha therapy in two melanoma patients.

[ [ "interferon alpha", "Livedo reticularis" ] ]

However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.

[ [ "clofibrate", "myopathy" ] ]

Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.

[ [ "adrenocorticotropic hormone", "Hyperkalemia" ] ]

This is the first reported case of suspected DIAN due to cefuroxime.

[ [ "cefuroxime", "DIAN" ] ]

A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).

[ [ "methotrexate", "ascites" ], [ "MTX", "ascites" ] ]

In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.

[ [ "spironolactone", "serious and, occasionally, fatal hyperkalaemia" ] ]

We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.

[ [ "PTU", "fulminant hepatitis" ] ]

In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.

[ [ "promethazine", "persistence of the photosensitivity" ], [ "promethazine", "cross-reaction to promethazine" ], [ "promethazine", "erythema" ], [ "mequitazine", "cross-reaction to promethazine" ], [ "mequitazine", "persistence of the photosensitivity" ], [ "mequitazine", "erythema" ], [ "mequitazine", "decreased MED to both UVA and UVB" ], [ "promethazine", "decreased MED to both UVA and UVB" ] ]

Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.

[ [ "Torsemide", "pancreatitis" ] ]

Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.

[ [ "imatinib", "blast crisis" ] ]

The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.

[ [ "5-fluorouracil", "cardiotoxicity" ], [ "5-FU", "cardiotoxicity" ] ]

OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.

[ [ "ofloxacin", "toxic epidermal necrolysis" ] ]

Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.

[ [ "warfarin", "haematoma" ], [ "warfarin", "discomfort" ], [ "warfarin", "diplopia" ], [ "warfarin", "lagophthalmos" ] ]

Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.

[ [ "DGTX", "cardiac DGTX toxicity" ], [ "DGTX", "total AV-block" ] ]

These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.

[ [ "aspirin", "RS" ] ]

Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.

[ [ "cefoxitin sodium", "acute deterioration of renal function" ] ]

A paradoxical ocular effect of brimonidine.

[ [ "brimonidine", "paradoxical ocular effect" ] ]

Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.

[ [ "heparin", "thrombocytopenia" ] ]

We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.

[ [ "prednisolone", "SJS" ] ]

Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.

[ [ "Procainamide", "incessant supraventricular tachycardia" ] ]

After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.

[ [ "Partusisten", "supraventricular tachycardia" ] ]

Severe abdominal pain in low dosage clofazimine.

[ [ "clofazimine", "abdominal pain" ] ]

PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.

[ [ "clomiphene citrate", "bilateral anterior uveitis" ] ]

Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".

[ [ "retinoic acid", "retinoic acid syndrome" ], [ "retinoic acid", "fatal complication" ] ]

Two patients are described who developed testicular swelling and pain during treatment with desipramine.

[ [ "desipramine", "testicular swelling" ], [ "desipramine", "pain" ] ]

Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.

[ [ "Treosulfan", "Acute non-lymphocytic leukemia" ], [ "dihydroxybusulfan", "Acute non-lymphocytic leukemia" ] ]

Isoniazid causing breast tissue enlargement has been very rarely reported.

[ [ "Isoniazid", "breast tissue enlargement" ] ]

It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.

[ [ "lead", "hypertension" ], [ "lead", "lead-induced hypertension" ] ]

Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.

[ [ "thrombin", "severe arterial thrombotic events" ] ]

One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.

[ [ "olanzapine", "extrapyramidal side effects" ] ]

We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.

[ [ "ethanol", "subcutaneous metastasis" ] ]

After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.

[ [ "ethambutol", "rash" ], [ "ethambutol", "polyarthritis" ], [ "ethambutol", "hepatitis" ], [ "ethambutol", "anti-native DNA antibodies" ] ]

Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.

[ [ "vitamin D", "hypercalcemia" ], [ "vitamin D", "acute vitamin D poisoning" ] ]

We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.

[ [ "fludarabine", "AML" ], [ "fludarabine", "lung cancer" ] ]

We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.

[ [ "gold", "respiratory failure" ] ]

Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.

[ [ "Propoxyphene", "wide QRS complex dysrhythmia" ] ]

Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.

[ [ "flutamide", "flutamide withdrawal syndrome" ], [ "flutamide", "Prolonged prostate-specific antigen response" ] ]

Ceftriaxone-induced fixed drug eruption: first report.

[ [ "Ceftriaxone", "fixed drug eruption" ] ]

PURPOSE: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity.

[ [ "hydroxychloroquine", "retinal toxicity" ] ]

A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.

[ [ "paclitaxel", "disabling neurotoxicity" ] ]

A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.

[ [ "methimazole", "agranulocytosis" ] ]

She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.

[ [ "metoclopramide", "dysarthria" ], [ "metoclopramide", "movement disorder" ], [ "metoclopramide", "agitation" ], [ "metoclopramide", "diaphoresis" ] ]

This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.

[ [ "erlotinib", "ILD" ] ]

Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.

[ [ "valproic acid", "coma" ] ]

2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.

[ [ "2-Chloro-deoxyadenosine", "non-Hodgkin's lymphoma" ] ]

Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.

[ [ "propranolol", "bronchospasm" ] ]

Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.

[ [ "carbamazepine", "SLE" ] ]

Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.

[ [ "alteplase", "Massive subfascial hematoma" ] ]

Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.

[ [ "interferon-beta", "bursitis" ], [ "interferon-beta", "Arthritis" ] ]

PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.

[ [ "interferon alfa", "sudden bilateral, sequential visual loss" ] ]

These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.

[ [ "propylthiouracil", "hepatic injury" ], [ "propylthiouracil", "submassive hepatic necrosis" ] ]

According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.

[ [ "enoxaparin", "hepatotoxicity" ] ]

Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.

[ [ "imatinib", "tumor lysis syndrome" ] ]

Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.

[ [ "arginine monohydrochloride", "Marked hyperkalemia" ] ]

DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.

[ [ "Olanzapine", "muscle injury with concomitant elevations of serum CK" ] ]

The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).

[ [ "lithium", "neurotoxicity" ] ]

Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.

[ [ "pentamidine", "cardiotoxicity" ], [ "pentamidine", "second-degree heart block" ] ]

Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.

[ [ "INH", "neurotoxicity" ] ]

We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.

[ [ "celiprolol", "hypersensitivity pneumonitis" ] ]

Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.

[ [ "amiodarone", "pancreatitis" ], [ "amiodarone", "Pancreatitis" ] ]