harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Furosemide-associated fever.	[ [ "Furosemide", "fever" ] ]
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.	[ [ "indomethacin", "life-threatening water intoxication" ], [ "cyclophosphamide", "life-threatening water intoxication" ] ]
A lethal complication of peripheral vein vasopressin infusion.	[ [ "vasopressin", "lethal complication" ] ]
CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.	[ [ "clindamycin", "multiple watery stools" ], [ "clindamycin", "abdominal cramping" ] ]
Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.	[ [ "tacrolimus", "severe hepatocellular necrosis" ], [ "tacrolimus", "progressive liver failure" ] ]
OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.	[ [ "vasopressin", "skin necrosis" ] ]
In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.	[ [ "meperidine", "CNS depressive effects" ], [ "meperidine", "accumulation of the parent drug" ] ]
Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.	[ [ "Adrenaline", "dacryolith" ] ]
Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.	[ [ "yohimbine", "Severe Raynaud's phenomenon" ] ]
In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.	[ [ "quetiapine", "death" ] ]
Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.	[ [ "PAN", "sensorineural hearing loss" ], [ "methotrexate", "sensorineural hearing loss" ] ]
A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.	[ [ "propafenone", "adverse central nervous system effects" ], [ "propafenone", "dizziness" ] ]
Minocycline as a cause of drug-induced autoimmune hepatitis.	[ [ "Minocycline", "autoimmune hepatitis" ] ]
Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.	[ [ "infliximab", "sleep disordered breathing" ] ]
A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.	[ [ "sulindac", "isolated idential sensory neuropathy" ] ]
DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.	[ [ "Methotrexate", "papular eruption" ] ]
These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.	[ [ "sulpiride", "tardive dyskinesia" ] ]
Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.	[ [ "amiodarone", "acute hepatitis" ] ]
The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.	[ [ "amphotericin B", "seizures" ] ]
A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.	[ [ "gliclazide", "acute icteric hepatitis-like illness" ] ]
Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).	[ [ "Oxcarbazepine", "Drug Reaction with Eosinophilia and Systemic Symptoms" ], [ "Oxcarbazepine", "DRESS" ] ]
A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.	[ [ "hydroxyurea", "CML" ], [ "hydroxyurea", "chronic myeloid leukaemia" ] ]
Progressive interstitial lung disease from prolonged methotrexate therapy.	[ [ "methotrexate", "Progressive interstitial lung disease" ] ]
We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.	[ [ "ibuprofen", "meningitis" ] ]
The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.	[ [ "IVIG", "acute renal failure" ] ]
Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.	[ [ "risperidone", "Obsessive-compulsive symptoms" ] ]
Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.	[ [ "5-fluorouracil", "Transient asymptomatic bradycardia" ] ]
We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.	[ [ "mirtazapine", "intoxication" ] ]
Theophylline intoxication mimicking diabetic ketoacidosis in a child.	[ [ "Theophylline", "Theophylline intoxication" ] ]
Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.	[ [ "suramin", "renal failure" ] ]
The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.	[ [ "sunitinib", "fatigue" ], [ "sunitinib", "hypertension" ] ]
This is the first report of a disulfiram-like reaction with cefmenoxime.	[ [ "cefmenoxime", "disulfiram-like reaction" ] ]
Clofazimine enteropathy caused by crystal deposition can be life-threatening.	[ [ "Clofazimine", "enteropathy" ], [ "Clofazimine", "life-threatening" ] ]
Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.	[ [ "protamine", "type I anaphylaxis" ] ]
Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.	[ [ "lithium", "Transient central diabetes insipidus" ] ]
Intravitreal triamcinolone may have had an influence on the exacerbation of retinochoroiditis in the posterior pole of the patient.	[ [ "triamcinolone", "exacerbation of retinochoroiditis" ] ]
Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.	[ [ "heparin", "thrombocytopenia" ] ]
A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.	[ [ "anti-D IGIV", "acute hemoglobinemia" ], [ "anti-D IGIV", "hemoglobinuria" ] ]
Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.	[ [ "Lithium", "transient thyrotoxicosis" ] ]
Propranolol-induced hypertension in treatment of cocaine intoxication.	[ [ "Propranolol", "hypertension" ] ]
It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.	[ [ "troglitazone", "hepatotoxicity" ] ]
Magnesium toxicosis in two horses.	[ [ "Magnesium", "Magnesium toxicosis" ] ]
We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.	[ [ "amiodarone", "torsades de pointes" ] ]
One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.	[ [ "clioquinol", "SMON" ], [ "clioquinol", "acrodermatitis enteropathica" ] ]
We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.	[ [ "nifedipine", "rupture of a cerebral arterial aneurysm" ] ]
Life-threatening interstitial lung disease associated with trastuzumab: case report.	[ [ "trastuzumab", "interstitial lung disease" ] ]
Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.	[ [ "acyclovir", "excessive maternal and physician anxiety" ] ]
Both patients suddenly became hypotensive after injection of chymopapain into a disk.	[ [ "chymopapain", "hypotensive" ] ]
Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.	[ [ "oxygen", "pulmonary damage" ], [ "bleomycin", "pulmonary damage" ] ]
To our knowledge, this case is the first published report of levofloxacin-induced TEN.	[ [ "levofloxacin", "TEN" ] ]
We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.	[ [ "erlotinib", "skin manifestations" ] ]
Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.	[ [ "Prazosin", "hemorrhagic stroke" ] ]
We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.	[ [ "captopril", "pulmonary infiltrates with eosinophilia" ] ]
The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.	[ [ "lithium carbonate", "neuroleptic malignant syndrome" ], [ "amitriptyline", "neuroleptic malignant syndrome" ] ]
To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.	[ [ "enoxaparin", "generalized exanthem" ] ]
DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.	[ [ "5-FU", "stomatitis" ], [ "5-FU", "mucositis" ], [ "5-FU", "neurotoxicity" ], [ "5-FU", "diarrhea" ], [ "5-FU", "myelosuppression" ] ]
Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.	[ [ "thrombin", "arterial thrombosis" ] ]
Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.	[ [ "mefloquine", "severe hypoglycaemia" ] ]
Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.	[ [ "lidocaine", "methemoglobinemia" ] ]
To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.	[ [ "Propecia", "cataract" ] ]
Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.	[ [ "Chlormadinone acetate", "withdrawal syndrome" ] ]
A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.	[ [ "vinblastine", "grand mal seizures" ], [ "cisplatin", "grand mal seizures" ], [ "bleomycin", "grand mal seizures" ] ]
Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.	[ [ "vasopressin", "Skin necrosis" ] ]
Azathioprine can cause severe myelosuppression.	[ [ "Azathioprine", "myelosuppression" ] ]
Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.	[ [ "bleomycin", "Hemolytic uremic syndrome" ], [ "cis-platinum", "Hemolytic uremic syndrome" ], [ "vinblastine", "Hemolytic uremic syndrome" ] ]
OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.	[ [ "amphotericin B", "fatal cardiac arrhythmia" ] ]
Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.	[ [ "sulfamethoxazole", "Symptomatic hypoglycemia" ], [ "glipizide", "Symptomatic hypoglycemia" ], [ "trimethoprim", "Symptomatic hypoglycemia" ] ]
CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v. infusion.	[ [ "dobutamine", "myoclonic muscle spasms" ] ]
We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.	[ [ "amiodarone", "torsade de pointes" ] ]
We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.	[ [ "zoledronic acid", "severe unilateral posterior scleritis" ] ]
Our series of 3 patients supports a causal connection between bleomycin and scleroderma.	[ [ "bleomycin", "scleroderma" ] ]
We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.	[ [ "tacalcitol", "hypercalcemia" ], [ "tacalcitol", "hypercalciuria" ], [ "thiazide", "hypercalcemia" ], [ "thiazide", "hypercalciuria" ] ]
An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.	[ [ "Bromocryptine", "lost vision" ] ]
We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.	[ [ "vancomycin", "CSFE" ] ]
Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.	[ [ "calcitriol", "secondary hyperparathyroidism" ], [ "phosphate", "vitamin D intoxication" ], [ "phosphate", "potassium loss" ], [ "calcitriol", "vitamin D intoxication" ], [ "calcitriol", "potassium loss" ], [ "phosphate", "secondary hyperparathyroidism" ] ]
This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.	[ [ "ethambutol", "ethambutol toxicity" ], [ "ethambutol", "vision loss" ] ]
Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.	[ [ "metripranolol", "bilateral granulomatous anterior uveitis" ] ]
OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.	[ [ "risperidone", "increased mood symptoms" ] ]
Here, we describe levofloxacin-induced delirium with psychotic features in a relatively young, otherwise healthy female.	[ [ "levofloxacin", "delirium with psychotic features" ] ]
Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.	[ [ "triamcinolone", "Iatrogenic Cushing syndrome" ] ]
Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.	[ [ "tigecycline", "acute pancreatitis" ], [ "tigecycline", "severe abdominal pain" ], [ "tigecycline", "elevated pancreatic enzymes" ] ]
OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.	[ [ "ciprofloxacin", "psychosis" ] ]
We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.	[ [ "ceftriaxone", "FDE" ] ]
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.	[ [ "warfarin", "diarrhea" ], [ "warfarin", "over-anticoagulation" ] ]
RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.	[ [ "rifabutin", "corneal endothelial deposits" ] ]
Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.	[ [ "amphotericin B", "impaired renal function" ] ]
Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.	[ [ "Interferon-alpha", "focal segmental glomerulosclerosis" ] ]
Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.	[ [ "thrombin", "vasospasm" ], [ "thrombin", "multiple infarcts" ], [ "thrombin", "slow to awaken" ] ]
Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.	[ [ "5-fluorouracil", "acute renal toxicity" ], [ "mitomycin C", "acute renal toxicity" ] ]
We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).	[ [ "immunoglobulin", "hyperkalemia" ], [ "immunoglobulin", "nausea" ], [ "IVIG", "shortness of breath" ], [ "immunoglobulin", "azotemia" ], [ "IVIG", "hyperkalemia" ], [ "IVIG", "nausea" ], [ "immunoglobulin", "shortness of breath" ], [ "IVIG", "azotemia" ] ]
The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.	[ [ "rituximab", "massive cytokines liberation" ], [ "rituximab", "destruction of CD20 positive cells" ] ]
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).	[ [ "Pexid", "hepatic dysfunction" ], [ "perhexiline maleate", "hepatic dysfunction" ], [ "perhexiline maleate", "Papilloedema" ], [ "Pexid", "Papilloedema" ] ]
RESULTS: Budesonide use can cause contact dermatitis.	[ [ "Budesonide", "contact dermatitis" ] ]
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.	[ [ "sodium polystryrene sulfonate", "Colonic necrosis" ], [ "Kayexalate", "Colonic necrosis" ] ]
Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).	[ [ "BCNU", "Severe diffuse interstitial pneumonitis" ], [ "carmustine", "Severe diffuse interstitial pneumonitis" ] ]
Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.	[ [ "lithium", "nephrotoxicity" ], [ "lithium", "renal failure" ] ]
We present a case of hypereosinophilia related to zafirlukast therapy.	[ [ "zafirlukast", "hypereosinophilia" ] ]
In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.	[ [ "glatiramer acetate", "subcutaneous changes" ], [ "glatiramer acetate", "localized panniculitis" ] ]
This is the first report of pulmonary hypertension in an adult patient during lithium therapy.	[ [ "lithium", "pulmonary hypertension" ] ]
Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.	[ [ "belladonna", "anticonvulsant hypersensitivity syndrome" ], [ "ergotamine", "anticonvulsant hypersensitivity syndrome" ], [ "phenobarbital", "anticonvulsant hypersensitivity syndrome" ] ]

Furosemide-associated fever.

[ [ "Furosemide", "fever" ] ]

We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.

[ [ "indomethacin", "life-threatening water intoxication" ], [ "cyclophosphamide", "life-threatening water intoxication" ] ]

A lethal complication of peripheral vein vasopressin infusion.

[ [ "vasopressin", "lethal complication" ] ]

CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.

[ [ "clindamycin", "multiple watery stools" ], [ "clindamycin", "abdominal cramping" ] ]

Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.

[ [ "tacrolimus", "severe hepatocellular necrosis" ], [ "tacrolimus", "progressive liver failure" ] ]

OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.

[ [ "vasopressin", "skin necrosis" ] ]

In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.

[ [ "meperidine", "CNS depressive effects" ], [ "meperidine", "accumulation of the parent drug" ] ]

Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.

[ [ "Adrenaline", "dacryolith" ] ]

Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.

[ [ "yohimbine", "Severe Raynaud's phenomenon" ] ]

In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.

[ [ "quetiapine", "death" ] ]

Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.

[ [ "PAN", "sensorineural hearing loss" ], [ "methotrexate", "sensorineural hearing loss" ] ]

A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.

[ [ "propafenone", "adverse central nervous system effects" ], [ "propafenone", "dizziness" ] ]

Minocycline as a cause of drug-induced autoimmune hepatitis.

[ [ "Minocycline", "autoimmune hepatitis" ] ]

Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.

[ [ "infliximab", "sleep disordered breathing" ] ]

A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.

[ [ "sulindac", "isolated idential sensory neuropathy" ] ]

DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.

[ [ "Methotrexate", "papular eruption" ] ]

These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.

[ [ "sulpiride", "tardive dyskinesia" ] ]

Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.

[ [ "amiodarone", "acute hepatitis" ] ]

The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.

[ [ "amphotericin B", "seizures" ] ]

A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.

[ [ "gliclazide", "acute icteric hepatitis-like illness" ] ]

Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

[ [ "Oxcarbazepine", "Drug Reaction with Eosinophilia and Systemic Symptoms" ], [ "Oxcarbazepine", "DRESS" ] ]

A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.

[ [ "hydroxyurea", "CML" ], [ "hydroxyurea", "chronic myeloid leukaemia" ] ]

Progressive interstitial lung disease from prolonged methotrexate therapy.

[ [ "methotrexate", "Progressive interstitial lung disease" ] ]

We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.

[ [ "ibuprofen", "meningitis" ] ]

The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.

[ [ "IVIG", "acute renal failure" ] ]

Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.

[ [ "risperidone", "Obsessive-compulsive symptoms" ] ]

Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.

[ [ "5-fluorouracil", "Transient asymptomatic bradycardia" ] ]

We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.

[ [ "mirtazapine", "intoxication" ] ]

Theophylline intoxication mimicking diabetic ketoacidosis in a child.

[ [ "Theophylline", "Theophylline intoxication" ] ]

Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.

[ [ "suramin", "renal failure" ] ]

The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.

[ [ "sunitinib", "fatigue" ], [ "sunitinib", "hypertension" ] ]

This is the first report of a disulfiram-like reaction with cefmenoxime.

[ [ "cefmenoxime", "disulfiram-like reaction" ] ]

Clofazimine enteropathy caused by crystal deposition can be life-threatening.

[ [ "Clofazimine", "enteropathy" ], [ "Clofazimine", "life-threatening" ] ]

Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.

[ [ "protamine", "type I anaphylaxis" ] ]

Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.

[ [ "lithium", "Transient central diabetes insipidus" ] ]

Intravitreal triamcinolone may have had an influence on the exacerbation of retinochoroiditis in the posterior pole of the patient.

[ [ "triamcinolone", "exacerbation of retinochoroiditis" ] ]

Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.

[ [ "heparin", "thrombocytopenia" ] ]

A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.

[ [ "anti-D IGIV", "acute hemoglobinemia" ], [ "anti-D IGIV", "hemoglobinuria" ] ]

Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.

[ [ "Lithium", "transient thyrotoxicosis" ] ]

Propranolol-induced hypertension in treatment of cocaine intoxication.

[ [ "Propranolol", "hypertension" ] ]

It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.

[ [ "troglitazone", "hepatotoxicity" ] ]

Magnesium toxicosis in two horses.

[ [ "Magnesium", "Magnesium toxicosis" ] ]

We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.

[ [ "amiodarone", "torsades de pointes" ] ]

One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.

[ [ "clioquinol", "SMON" ], [ "clioquinol", "acrodermatitis enteropathica" ] ]

We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.

[ [ "nifedipine", "rupture of a cerebral arterial aneurysm" ] ]

Life-threatening interstitial lung disease associated with trastuzumab: case report.

[ [ "trastuzumab", "interstitial lung disease" ] ]

Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.

[ [ "acyclovir", "excessive maternal and physician anxiety" ] ]

Both patients suddenly became hypotensive after injection of chymopapain into a disk.

[ [ "chymopapain", "hypotensive" ] ]

Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.

[ [ "oxygen", "pulmonary damage" ], [ "bleomycin", "pulmonary damage" ] ]

To our knowledge, this case is the first published report of levofloxacin-induced TEN.

[ [ "levofloxacin", "TEN" ] ]

We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.

[ [ "erlotinib", "skin manifestations" ] ]

Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.

[ [ "Prazosin", "hemorrhagic stroke" ] ]

We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.

[ [ "captopril", "pulmonary infiltrates with eosinophilia" ] ]

The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.

[ [ "lithium carbonate", "neuroleptic malignant syndrome" ], [ "amitriptyline", "neuroleptic malignant syndrome" ] ]

To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.

[ [ "enoxaparin", "generalized exanthem" ] ]

DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.

[ [ "5-FU", "stomatitis" ], [ "5-FU", "mucositis" ], [ "5-FU", "neurotoxicity" ], [ "5-FU", "diarrhea" ], [ "5-FU", "myelosuppression" ] ]

Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.

[ [ "thrombin", "arterial thrombosis" ] ]

Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.

[ [ "mefloquine", "severe hypoglycaemia" ] ]

Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.

[ [ "lidocaine", "methemoglobinemia" ] ]

To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.

[ [ "Propecia", "cataract" ] ]

Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.

[ [ "Chlormadinone acetate", "withdrawal syndrome" ] ]

A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.

[ [ "vinblastine", "grand mal seizures" ], [ "cisplatin", "grand mal seizures" ], [ "bleomycin", "grand mal seizures" ] ]

Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.

[ [ "vasopressin", "Skin necrosis" ] ]

Azathioprine can cause severe myelosuppression.

[ [ "Azathioprine", "myelosuppression" ] ]

Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.

[ [ "bleomycin", "Hemolytic uremic syndrome" ], [ "cis-platinum", "Hemolytic uremic syndrome" ], [ "vinblastine", "Hemolytic uremic syndrome" ] ]

OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.

[ [ "amphotericin B", "fatal cardiac arrhythmia" ] ]

Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.

[ [ "sulfamethoxazole", "Symptomatic hypoglycemia" ], [ "glipizide", "Symptomatic hypoglycemia" ], [ "trimethoprim", "Symptomatic hypoglycemia" ] ]

CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v. infusion.

[ [ "dobutamine", "myoclonic muscle spasms" ] ]

We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.

[ [ "amiodarone", "torsade de pointes" ] ]

We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.

[ [ "zoledronic acid", "severe unilateral posterior scleritis" ] ]

Our series of 3 patients supports a causal connection between bleomycin and scleroderma.

[ [ "bleomycin", "scleroderma" ] ]

We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.

[ [ "tacalcitol", "hypercalcemia" ], [ "tacalcitol", "hypercalciuria" ], [ "thiazide", "hypercalcemia" ], [ "thiazide", "hypercalciuria" ] ]

An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.

[ [ "Bromocryptine", "lost vision" ] ]

We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.

[ [ "vancomycin", "CSFE" ] ]

Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.

[ [ "calcitriol", "secondary hyperparathyroidism" ], [ "phosphate", "vitamin D intoxication" ], [ "phosphate", "potassium loss" ], [ "calcitriol", "vitamin D intoxication" ], [ "calcitriol", "potassium loss" ], [ "phosphate", "secondary hyperparathyroidism" ] ]

This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.

[ [ "ethambutol", "ethambutol toxicity" ], [ "ethambutol", "vision loss" ] ]

Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.

[ [ "metripranolol", "bilateral granulomatous anterior uveitis" ] ]

OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.

[ [ "risperidone", "increased mood symptoms" ] ]

Here, we describe levofloxacin-induced delirium with psychotic features in a relatively young, otherwise healthy female.

[ [ "levofloxacin", "delirium with psychotic features" ] ]

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

[ [ "triamcinolone", "Iatrogenic Cushing syndrome" ] ]

Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.

[ [ "tigecycline", "acute pancreatitis" ], [ "tigecycline", "severe abdominal pain" ], [ "tigecycline", "elevated pancreatic enzymes" ] ]

OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.

[ [ "ciprofloxacin", "psychosis" ] ]

We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.

[ [ "ceftriaxone", "FDE" ] ]

We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.

[ [ "warfarin", "diarrhea" ], [ "warfarin", "over-anticoagulation" ] ]

RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.

[ [ "rifabutin", "corneal endothelial deposits" ] ]

Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.

[ [ "amphotericin B", "impaired renal function" ] ]

Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.

[ [ "Interferon-alpha", "focal segmental glomerulosclerosis" ] ]

Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.

[ [ "thrombin", "vasospasm" ], [ "thrombin", "multiple infarcts" ], [ "thrombin", "slow to awaken" ] ]

Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.

[ [ "5-fluorouracil", "acute renal toxicity" ], [ "mitomycin C", "acute renal toxicity" ] ]

We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).

[ [ "immunoglobulin", "hyperkalemia" ], [ "immunoglobulin", "nausea" ], [ "IVIG", "shortness of breath" ], [ "immunoglobulin", "azotemia" ], [ "IVIG", "hyperkalemia" ], [ "IVIG", "nausea" ], [ "immunoglobulin", "shortness of breath" ], [ "IVIG", "azotemia" ] ]

The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.

[ [ "rituximab", "massive cytokines liberation" ], [ "rituximab", "destruction of CD20 positive cells" ] ]

Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).

[ [ "Pexid", "hepatic dysfunction" ], [ "perhexiline maleate", "hepatic dysfunction" ], [ "perhexiline maleate", "Papilloedema" ], [ "Pexid", "Papilloedema" ] ]

RESULTS: Budesonide use can cause contact dermatitis.

[ [ "Budesonide", "contact dermatitis" ] ]

Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.

[ [ "sodium polystryrene sulfonate", "Colonic necrosis" ], [ "Kayexalate", "Colonic necrosis" ] ]

Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).

[ [ "BCNU", "Severe diffuse interstitial pneumonitis" ], [ "carmustine", "Severe diffuse interstitial pneumonitis" ] ]

Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.

[ [ "lithium", "nephrotoxicity" ], [ "lithium", "renal failure" ] ]

We present a case of hypereosinophilia related to zafirlukast therapy.

[ [ "zafirlukast", "hypereosinophilia" ] ]

In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.

[ [ "glatiramer acetate", "subcutaneous changes" ], [ "glatiramer acetate", "localized panniculitis" ] ]

This is the first report of pulmonary hypertension in an adult patient during lithium therapy.

[ [ "lithium", "pulmonary hypertension" ] ]

Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.

[ [ "belladonna", "anticonvulsant hypersensitivity syndrome" ], [ "ergotamine", "anticonvulsant hypersensitivity syndrome" ], [ "phenobarbital", "anticonvulsant hypersensitivity syndrome" ] ]