harpreetmann/entity_extraction_ade · Datasets at Hugging Face

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We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.	[ [ "etoposide", "paroxysmal supraventricular tachycardia" ], [ "cisplatin", "paroxysmal supraventricular tachycardia" ] ]
Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.	[ [ "hydrochlorothiazide", "Chronic photosensitivity" ] ]
Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.	[ [ "disopyramide", "AVT" ], [ "disopyramide", "syncope" ] ]
Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.	[ [ "infliximab", "antinuclear antibodies" ], [ "infliximab", "increase of autoantibodies" ], [ "infliximab", "anti-double-stranded DNA" ] ]
Terlipressin-induced ventricular arrhythmia.	[ [ "Terlipressin", "ventricular arrhythmia" ] ]
INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.	[ [ "stavudine", "hyperlactatemia" ] ]
CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.	[ [ "econazole", "laryngeal hematoma" ], [ "acenocoumarol", "laryngeal hematoma" ] ]
It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.	[ [ "capecitabine", "allergic reaction" ] ]
Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.	[ [ "calcium stearate", "Acute eosinophilic pneumonia" ] ]
We present a case of sotalol-induced bradycardia reversed by glucagon.	[ [ "sotalol", "bradycardia" ] ]
A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.	[ [ "nefazodone", "benzodiazepine withdrawal symptoms" ] ]
METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.	[ [ "insulin", "angioedema" ], [ "insulin", "wheezing" ], [ "insulin", "severe urticaria" ] ]
The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.	[ [ "leflunomide", "severe infections" ] ]
One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.	[ [ "griseofulvin", "erythema multiforme" ] ]
Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.	[ [ "Ticlopidine", "aplastic anemia" ] ]
A lupus-like syndrome associated with infliximab therapy.	[ [ "infliximab", "lupus-like syndrome" ] ]
The electrocardiogram (ECG), which was read as normal prior to ritodrine infusion, demonstrated a type I second-degree AV block which disappeared upon discontinuation of ritodrine therapy.	[ [ "ritodrine", "type I second-degree AV block" ] ]
DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.	[ [ "Interferon alpha-2b", "cardiomyopathy" ] ]
Carbamazepine-induced systemic lupus erythematosus.	[ [ "Carbamazepine", "systemic lupus erythematosus" ] ]
Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.	[ [ "mirtazapine", "symptomatic hyponatremia" ] ]
An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.	[ [ "Levemepromazine", "respiratory distress syndrome" ], [ "methotrimeprazine meleate", "respiratory distress syndrome" ] ]
Early ritonavir-induced maculopapular eruption.	[ [ "ritonavir", "maculopapular eruption" ] ]
A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.	[ [ "phenytoin", "periodic alternating nystagmus" ] ]
The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.	[ [ "warfarin", "sub-conjunctival haematoma" ] ]
Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.	[ [ "pirmenol", "T wave inversion" ], [ "pirmenol", "QT prolongation" ] ]
Inadvertent and accidental epinephrine overdose might result in potentially lethal complications.	[ [ "epinephrine", "lethal complications" ] ]
Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.	[ [ "5-fluorouracil", "Glaucoma" ] ]
Acute coronary syndromes complicating the first infusion of rituximab.	[ [ "rituximab", "Acute coronary syndromes" ] ]
This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.	[ [ "theophylline", "theophylline poisoning" ] ]
We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.	[ [ "heparin", "hyperkalemia" ] ]
Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.	[ [ "Methotrexate", "Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder" ], [ "MTX", "Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder" ] ]
Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.	[ [ "Amikacin", "type 5 Bartter-like syndrome" ], [ "Amikacin", "severe hypocalcemia" ] ]
Toxic epidermal necrolysis associated with interleukin-2.	[ [ "interleukin-2", "Toxic epidermal necrolysis" ] ]
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.	[ [ "enalapril", "acute renal failure" ] ]
Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.	[ [ "itraconazole", "severe symptomatic hepatitis" ] ]
Severe dapsone hypersensitivity syndrome.	[ [ "dapsone", "hypersensitivity syndrome" ] ]
Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.	[ [ "insulin", "hypoglycemia" ], [ "insulin", "rebound hyperglycemia" ] ]
Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.	[ [ "hydroxyurea", "Acute myeloid leukemia" ] ]
Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.	[ [ "isotretinoin", "sclerotic changes of lumbar spine and femur" ] ]
Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.	[ [ "gabapentin", "anxiety" ], [ "gabapentin", "generalized seizures" ], [ "gabapentin", "status epilepticus" ], [ "gabapentin", "palpitations" ], [ "gabapentin", "diaphoresis" ] ]
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.	[ [ "disopyramide", "arrhythmia" ], [ "amiodarone", "torsade de pointes" ], [ "amiodarone", "Atypical ventricular tachycardia" ], [ "quinidine", "arrhythmia" ] ]
Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.	[ [ "trazodone", "hypomanic symptoms" ] ]
The 3-week sulphasalazine syndrome strikes again.	[ [ "sulphasalazine", "sulphasalazine syndrome" ] ]
Co-trimoxazole red cell aplasia in leukaemia.	[ [ "Co-trimoxazole", "red cell aplasia" ] ]
Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.	[ [ "insulin", "pleural effusion" ], [ "insulin", "peripheral oedema" ], [ "insulin", "severe anasarca" ], [ "insulin", "ascites" ] ]
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.	[ [ "amiodarone", "interstitial pneumopathy" ] ]
Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.	[ [ "interferon alpha", "renal dysfunction" ], [ "IFNalpha", "renal dysfunction" ] ]
The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.	[ [ "olanzapine", "uncontrolled diabetes mellitus" ], [ "olanzapine", "weight gain" ] ]
L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.	[ [ "L-DOPA", "daytime sleepiness" ] ]
In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.	[ [ "senna", "liver injury" ], [ "senna", "subacute cholestatic hepatitis" ] ]
Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.	[ [ "phenylpropanolamine", "Cerebral infarcts" ] ]
Seizures associated with ofloxacin therapy.	[ [ "ofloxacin", "Seizures" ] ]
Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.	[ [ "senna", "Subacute cholestatic hepatitis" ] ]
Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.	[ [ "quinidine", "iatrogenic hypoglycaemia" ], [ "Quinine", "iatrogenic hypoglycaemia" ] ]
BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.	[ [ "captopril", "delated cutaneous reactions" ] ]
The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.	[ [ "ribavirin", "type 1 diabetes mellitus" ], [ "recombinant alpha-2b peginterferon", "type 1 diabetes mellitus" ] ]
We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.	[ [ "VGB", "ophthalmic and neurologic findings" ] ]
We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.	[ [ "L-thyroxine", "coronary spasm" ], [ "L-thyroxine", "myocardial infarction" ] ]
Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.	[ [ "interferon alpha", "Vogt-Koyanagi-Harada disease" ], [ "interferon", "Vogt-Koyanagi-Harada disease" ] ]
Ten to 15% of patients treated with ifosfamide develop an encephalopathy.	[ [ "ifosfamide", "encephalopathy" ] ]
CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.	[ [ "vancomycin", "neutropenia" ] ]
Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.	[ [ "carbamazepine", "Cutaneous rashes" ], [ "carbamazepine", "eruptions" ] ]
We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.	[ [ "gliclazide", "acute hepatitis" ] ]
We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.	[ [ "Budefat", "sore throat" ], [ "Budefat", "dysphagia" ], [ "budesonide", "dysphagia" ], [ "budesonide", "swelling of the lips and oral cavity" ], [ "budesonide", "sore throat" ], [ "Budefat", "swelling of the lips and oral cavity" ] ]
OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.	[ [ "amphotericin B", "seizure" ] ]
Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.	[ [ "metformin", "Severe acidosis" ] ]
OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.	[ [ "indapamide", "diabetes" ], [ "indapamide", "impairing carbohydrate metabolism" ] ]
Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients.	[ [ "Ritonavir", "adverse cutaneous reactions" ] ]
A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.	[ [ "vinyl chloride", "hepatic angiosarcoma" ], [ "Thorotrast", "hepatic angiosarcoma" ], [ "inorganic arsenic", "hepatic angiosarcoma" ] ]
Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.	[ [ "azathioprine", "Drug eruption" ] ]
L-asparaginase-provoked seizures as singular expression of central nervous toxicity.	[ [ "L-asparaginase", "seizures" ], [ "L-asparaginase", "central nervous toxicity" ] ]
The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.	[ [ "L-dopa", "daytime somnolence" ] ]
A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.	[ [ "pemetrexed", "melanonychia" ], [ "pemetrexed", "onycholysis" ] ]
We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.	[ [ "vincristine", "hepatotoxicity" ], [ "actinomycin D", "hepatotoxicity" ] ]
We report a case of chronic use of HCQ associated with torsade de pointes.	[ [ "HCQ", "torsade de pointes" ] ]
A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.	[ [ "adalimumab", "jaundice" ], [ "adalimumab", "tachypnea" ], [ "adalimumab", "severe dyspnea" ] ]
Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.	[ [ "quinine", "thrombocytopenia" ] ]
Increasing the olanzapine dosage severely aggravated the symptoms of RLS.	[ [ "olanzapine", "RLS" ] ]
Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.	[ [ "MTX", "ascites" ] ]
Camptocormia, a new side effect of sodium valproate.	[ [ "sodium valproate", "Camptocormia" ] ]
A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.	[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "altered mental status" ], [ "desmopressin", "seizures" ] ]
We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.	[ [ "docetaxel", "severe respiratory insufficiency" ], [ "gemcitabine", "severe respiratory insufficiency" ], [ "gemcitabine", "progression of the tumor" ], [ "docetaxel", "BOOP" ], [ "gemcitabine", "BOOP" ], [ "docetaxel", "progression of the tumor" ] ]
Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.	[ [ "Gold", "nephropathy" ] ]
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.	[ [ "saquinavir", "carbamazepine toxicity" ], [ "ritonavir", "progressive ataxia" ], [ "carbamazepine", "carbamazepine toxicity" ], [ "carbamazepine", "progressive ataxia" ], [ "ritonavir", "carbamazepine toxicity" ], [ "saquinavir", "progressive ataxia" ] ]
The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.	[ [ "rituximab", "acute coronary syndromes" ] ]
CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.	[ [ "verapamil", "asthma attack" ] ]
The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.	[ [ "imiquimod", "exacerbation of psoriasis" ] ]
Rifampin-induced hypothyroidism without underlying thyroid disease.	[ [ "Rifampin", "hypothyroidism" ] ]
We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.	[ [ "cisplatin", "localized pigmentation" ], [ "etoposide", "localized pigmentation" ], [ "bleomycin", "localized pigmentation" ] ]
A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.	[ [ "streptokinase", "fatal massive pulmonary embolus" ] ]
Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.	[ [ "etanercept", "CD" ] ]
In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.	[ [ "cyclosporine", "CIPS" ] ]
We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.	[ [ "efalizumab", "eruptive mollusca contagiosa" ] ]
A case of colchicine-induced rhabdomyolysis is reported.	[ [ "colchicine", "rhabdomyolysis" ] ]
Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.	[ [ "Metamizole", "agranulocytosis" ] ]
We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.	[ [ "pFVIII", "thrombosis" ] ]
We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.	[ [ "docetaxel", "eye irritation and dryness" ] ]
We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	[ [ "CBZ", "neurotoxicity" ], [ "clozapine", "asterixis" ], [ "lithium", "neurotoxicity" ], [ "lithium", "asterixis" ], [ "CBZ", "asterixis" ], [ "clozapine", "neurotoxicity" ] ]
Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.	[ [ "bevacizumab", "Acute ocular ischemic change" ] ]
A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.	[ [ "natalizumab", "PCNSL" ], [ "natalizumab", "primary central nervous system lymphoma" ] ]

We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.

[ [ "etoposide", "paroxysmal supraventricular tachycardia" ], [ "cisplatin", "paroxysmal supraventricular tachycardia" ] ]

Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.

[ [ "hydrochlorothiazide", "Chronic photosensitivity" ] ]

Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.

[ [ "disopyramide", "AVT" ], [ "disopyramide", "syncope" ] ]

Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.

[ [ "infliximab", "antinuclear antibodies" ], [ "infliximab", "increase of autoantibodies" ], [ "infliximab", "anti-double-stranded DNA" ] ]

Terlipressin-induced ventricular arrhythmia.

[ [ "Terlipressin", "ventricular arrhythmia" ] ]

INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.

[ [ "stavudine", "hyperlactatemia" ] ]

CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.

[ [ "econazole", "laryngeal hematoma" ], [ "acenocoumarol", "laryngeal hematoma" ] ]

It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.

[ [ "capecitabine", "allergic reaction" ] ]

Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.

[ [ "calcium stearate", "Acute eosinophilic pneumonia" ] ]

We present a case of sotalol-induced bradycardia reversed by glucagon.

[ [ "sotalol", "bradycardia" ] ]

A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.

[ [ "nefazodone", "benzodiazepine withdrawal symptoms" ] ]

METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.

[ [ "insulin", "angioedema" ], [ "insulin", "wheezing" ], [ "insulin", "severe urticaria" ] ]

The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.

[ [ "leflunomide", "severe infections" ] ]

One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.

[ [ "griseofulvin", "erythema multiforme" ] ]

Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.

[ [ "Ticlopidine", "aplastic anemia" ] ]

A lupus-like syndrome associated with infliximab therapy.

[ [ "infliximab", "lupus-like syndrome" ] ]

The electrocardiogram (ECG), which was read as normal prior to ritodrine infusion, demonstrated a type I second-degree AV block which disappeared upon discontinuation of ritodrine therapy.

[ [ "ritodrine", "type I second-degree AV block" ] ]

DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.

[ [ "Interferon alpha-2b", "cardiomyopathy" ] ]

Carbamazepine-induced systemic lupus erythematosus.

[ [ "Carbamazepine", "systemic lupus erythematosus" ] ]

Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.

[ [ "mirtazapine", "symptomatic hyponatremia" ] ]

An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.

[ [ "Levemepromazine", "respiratory distress syndrome" ], [ "methotrimeprazine meleate", "respiratory distress syndrome" ] ]

Early ritonavir-induced maculopapular eruption.

[ [ "ritonavir", "maculopapular eruption" ] ]

A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.

[ [ "phenytoin", "periodic alternating nystagmus" ] ]

The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.

[ [ "warfarin", "sub-conjunctival haematoma" ] ]

Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.

[ [ "pirmenol", "T wave inversion" ], [ "pirmenol", "QT prolongation" ] ]

Inadvertent and accidental epinephrine overdose might result in potentially lethal complications.

[ [ "epinephrine", "lethal complications" ] ]

Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.

[ [ "5-fluorouracil", "Glaucoma" ] ]

Acute coronary syndromes complicating the first infusion of rituximab.

[ [ "rituximab", "Acute coronary syndromes" ] ]

This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.

[ [ "theophylline", "theophylline poisoning" ] ]

We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.

[ [ "heparin", "hyperkalemia" ] ]

Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.

[ [ "Methotrexate", "Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder" ], [ "MTX", "Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder" ] ]

Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.

[ [ "Amikacin", "type 5 Bartter-like syndrome" ], [ "Amikacin", "severe hypocalcemia" ] ]

Toxic epidermal necrolysis associated with interleukin-2.

[ [ "interleukin-2", "Toxic epidermal necrolysis" ] ]

A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.

[ [ "enalapril", "acute renal failure" ] ]

Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.

[ [ "itraconazole", "severe symptomatic hepatitis" ] ]

Severe dapsone hypersensitivity syndrome.

[ [ "dapsone", "hypersensitivity syndrome" ] ]

Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.

[ [ "insulin", "hypoglycemia" ], [ "insulin", "rebound hyperglycemia" ] ]

Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.

[ [ "hydroxyurea", "Acute myeloid leukemia" ] ]

Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.

[ [ "isotretinoin", "sclerotic changes of lumbar spine and femur" ] ]

Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.

[ [ "gabapentin", "anxiety" ], [ "gabapentin", "generalized seizures" ], [ "gabapentin", "status epilepticus" ], [ "gabapentin", "palpitations" ], [ "gabapentin", "diaphoresis" ] ]

Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

[ [ "disopyramide", "arrhythmia" ], [ "amiodarone", "torsade de pointes" ], [ "amiodarone", "Atypical ventricular tachycardia" ], [ "quinidine", "arrhythmia" ] ]

Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.

[ [ "trazodone", "hypomanic symptoms" ] ]

The 3-week sulphasalazine syndrome strikes again.

[ [ "sulphasalazine", "sulphasalazine syndrome" ] ]

Co-trimoxazole red cell aplasia in leukaemia.

[ [ "Co-trimoxazole", "red cell aplasia" ] ]

Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.

[ [ "insulin", "pleural effusion" ], [ "insulin", "peripheral oedema" ], [ "insulin", "severe anasarca" ], [ "insulin", "ascites" ] ]

In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.

[ [ "amiodarone", "interstitial pneumopathy" ] ]

Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.

[ [ "interferon alpha", "renal dysfunction" ], [ "IFNalpha", "renal dysfunction" ] ]

The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.

[ [ "olanzapine", "uncontrolled diabetes mellitus" ], [ "olanzapine", "weight gain" ] ]

L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.

[ [ "L-DOPA", "daytime sleepiness" ] ]

In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.

[ [ "senna", "liver injury" ], [ "senna", "subacute cholestatic hepatitis" ] ]

Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.

[ [ "phenylpropanolamine", "Cerebral infarcts" ] ]

Seizures associated with ofloxacin therapy.

[ [ "ofloxacin", "Seizures" ] ]

Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.

[ [ "senna", "Subacute cholestatic hepatitis" ] ]

Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.

[ [ "quinidine", "iatrogenic hypoglycaemia" ], [ "Quinine", "iatrogenic hypoglycaemia" ] ]

BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.

[ [ "captopril", "delated cutaneous reactions" ] ]

The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.

[ [ "ribavirin", "type 1 diabetes mellitus" ], [ "recombinant alpha-2b peginterferon", "type 1 diabetes mellitus" ] ]

We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.

[ [ "VGB", "ophthalmic and neurologic findings" ] ]

We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.

[ [ "L-thyroxine", "coronary spasm" ], [ "L-thyroxine", "myocardial infarction" ] ]

Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.

[ [ "interferon alpha", "Vogt-Koyanagi-Harada disease" ], [ "interferon", "Vogt-Koyanagi-Harada disease" ] ]

Ten to 15% of patients treated with ifosfamide develop an encephalopathy.

[ [ "ifosfamide", "encephalopathy" ] ]

CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.

[ [ "vancomycin", "neutropenia" ] ]

Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.

[ [ "carbamazepine", "Cutaneous rashes" ], [ "carbamazepine", "eruptions" ] ]

We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.

[ [ "gliclazide", "acute hepatitis" ] ]

We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.

[ [ "Budefat", "sore throat" ], [ "Budefat", "dysphagia" ], [ "budesonide", "dysphagia" ], [ "budesonide", "swelling of the lips and oral cavity" ], [ "budesonide", "sore throat" ], [ "Budefat", "swelling of the lips and oral cavity" ] ]

OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.

[ [ "amphotericin B", "seizure" ] ]

Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.

[ [ "metformin", "Severe acidosis" ] ]

OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.

[ [ "indapamide", "diabetes" ], [ "indapamide", "impairing carbohydrate metabolism" ] ]

Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients.

[ [ "Ritonavir", "adverse cutaneous reactions" ] ]

A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.

[ [ "vinyl chloride", "hepatic angiosarcoma" ], [ "Thorotrast", "hepatic angiosarcoma" ], [ "inorganic arsenic", "hepatic angiosarcoma" ] ]

Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.

[ [ "azathioprine", "Drug eruption" ] ]

L-asparaginase-provoked seizures as singular expression of central nervous toxicity.

[ [ "L-asparaginase", "seizures" ], [ "L-asparaginase", "central nervous toxicity" ] ]

The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.

[ [ "L-dopa", "daytime somnolence" ] ]

A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.

[ [ "pemetrexed", "melanonychia" ], [ "pemetrexed", "onycholysis" ] ]

We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.

[ [ "vincristine", "hepatotoxicity" ], [ "actinomycin D", "hepatotoxicity" ] ]

We report a case of chronic use of HCQ associated with torsade de pointes.

[ [ "HCQ", "torsade de pointes" ] ]

A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.

[ [ "adalimumab", "jaundice" ], [ "adalimumab", "tachypnea" ], [ "adalimumab", "severe dyspnea" ] ]

Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.

[ [ "quinine", "thrombocytopenia" ] ]

Increasing the olanzapine dosage severely aggravated the symptoms of RLS.

[ [ "olanzapine", "RLS" ] ]

Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.

[ [ "MTX", "ascites" ] ]

Camptocormia, a new side effect of sodium valproate.

[ [ "sodium valproate", "Camptocormia" ] ]

A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.

[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "altered mental status" ], [ "desmopressin", "seizures" ] ]

We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.

[ [ "docetaxel", "severe respiratory insufficiency" ], [ "gemcitabine", "severe respiratory insufficiency" ], [ "gemcitabine", "progression of the tumor" ], [ "docetaxel", "BOOP" ], [ "gemcitabine", "BOOP" ], [ "docetaxel", "progression of the tumor" ] ]

Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.

[ [ "Gold", "nephropathy" ] ]

Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.

[ [ "saquinavir", "carbamazepine toxicity" ], [ "ritonavir", "progressive ataxia" ], [ "carbamazepine", "carbamazepine toxicity" ], [ "carbamazepine", "progressive ataxia" ], [ "ritonavir", "carbamazepine toxicity" ], [ "saquinavir", "progressive ataxia" ] ]

The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.

[ [ "rituximab", "acute coronary syndromes" ] ]

CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.

[ [ "verapamil", "asthma attack" ] ]

The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.

[ [ "imiquimod", "exacerbation of psoriasis" ] ]

Rifampin-induced hypothyroidism without underlying thyroid disease.

[ [ "Rifampin", "hypothyroidism" ] ]

We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.

[ [ "cisplatin", "localized pigmentation" ], [ "etoposide", "localized pigmentation" ], [ "bleomycin", "localized pigmentation" ] ]

A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.

[ [ "streptokinase", "fatal massive pulmonary embolus" ] ]

Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.

[ [ "etanercept", "CD" ] ]

In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.

[ [ "cyclosporine", "CIPS" ] ]

We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.

[ [ "efalizumab", "eruptive mollusca contagiosa" ] ]

A case of colchicine-induced rhabdomyolysis is reported.

[ [ "colchicine", "rhabdomyolysis" ] ]

Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.

[ [ "Metamizole", "agranulocytosis" ] ]

We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.

[ [ "pFVIII", "thrombosis" ] ]

We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.

[ [ "docetaxel", "eye irritation and dryness" ] ]

We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.

[ [ "CBZ", "neurotoxicity" ], [ "clozapine", "asterixis" ], [ "lithium", "neurotoxicity" ], [ "lithium", "asterixis" ], [ "CBZ", "asterixis" ], [ "clozapine", "neurotoxicity" ] ]

Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.

[ [ "bevacizumab", "Acute ocular ischemic change" ] ]

A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.

[ [ "natalizumab", "PCNSL" ], [ "natalizumab", "primary central nervous system lymphoma" ] ]