harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.	[ [ "clomipramine", "serotonin syndrome" ] ]
Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.	[ [ "imatinib mesylate", "blast crisis" ] ]
This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.	[ [ "fluvoxamine", "Schneiderian first-rank symptoms" ] ]
AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).	[ [ "Glypressin", "skin necrosis" ], [ "terlipressin", "skin necrosis" ] ]
Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.	[ [ "tamoxifen", "Gastric tumor" ], [ "tamoxifen", "endometrial carcinoma" ], [ "tamoxifen", "cervical adenocarcinoma" ] ]
Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.	[ [ "mitomycin", "hemolytic-uremic syndrome" ] ]
The most common complication of warfarin use is adverse bleeding.	[ [ "warfarin", "bleeding" ] ]
In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.	[ [ "halofantrine", "QT interval was prolonged" ] ]
We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.	[ [ "ivermectin", "severe hepatitis" ] ]
Development of tics in a thirteen-year-old male following atomoxetine use.	[ [ "atomoxetine", "tics" ] ]
CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.	[ [ "Alendronate", "nodular scleritis" ], [ "Alendronate", "scleritis" ] ]
However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.	[ [ "teicoplanin", "neutropenia" ] ]
A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.	[ [ "methotrexate", "toxic hepatitis" ], [ "etretinate", "toxic hepatitis" ] ]
Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.	[ [ "aspirin", "angioedema" ], [ "aspirin", "systemic anaphylactoid reaction" ], [ "aspirin", "urticaria" ] ]
The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.	[ [ "itraconazole", "tremor" ] ]
We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.	[ [ "foscarnet", "CMV infection" ], [ "ganciclovir", "CMV infection" ], [ "cidofovir", "CMV infection" ] ]
Quinine induced coagulopathy--a near fatal experience.	[ [ "Quinine", "coagulopathy" ] ]
We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.	[ [ "doxorubicin", "mucositis" ], [ "dexamethasone", "gastritis" ] ]
Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.	[ [ "heparin", "thrombosis" ] ]
Dyspnea possibly associated with controlled-release morphine sulfate tablets.	[ [ "morphine sulfate", "Dyspnea" ] ]
CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.	[ [ "gemcitabine", "HUS" ] ]
Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.	[ [ "ticlopidine", "pulmonary symptoms" ] ]
A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.	[ [ "capecitabine", "headache" ] ]
There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.	[ [ "liothyronine", "hyperthyroidism" ] ]
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.	[ [ "lithium", "lithium intoxication" ], [ "lithium", "diabetes insipidus-like syndrome" ], [ "Lithium", "lithium intoxication" ], [ "Lithium", "diabetes insipidus-like syndrome" ] ]
Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.	[ [ "Captopril", "bone marrow suppression" ] ]
L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.	[ [ "valproic acid", "fatal hepatotoxic effects" ] ]
The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.	[ [ "thiabendazole", "cholestasis" ], [ "thiabendazole", "sicca complex" ] ]
BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.	[ [ "capecitabine", "Headaches" ] ]
These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.	[ [ "interferon alpha", "livedo reticularis" ] ]
Naproxen-associated sudden sensorineural hearing loss.	[ [ "Naproxen", "sudden sensorineural hearing loss" ] ]
We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.	[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "grand mal seizure" ] ]
Angioedema and maculopapular eruptions associated with carbamazepine administration.	[ [ "carbamazepine", "maculopapular eruptions" ], [ "carbamazepine", "Angioedema" ] ]
METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.	[ [ "imiquimod", "verrucous plaque" ] ]
We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.	[ [ "methanol", "cerebral edema" ], [ "methanol", "ventricular compression" ], [ "methanol", "diffuse brain involvement" ], [ "methanol", "bilateral putaminal necrosis" ], [ "methanol", "fatal" ], [ "methanol", "methanol toxicity" ] ]
We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.	[ [ "gemcitabine", "radiation-recall" ], [ "gemcitabine", "gastrointestinal bleeding" ] ]
Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.	[ [ "etoposide", "pulmonary toxicity" ] ]
Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.	[ [ "phenylbutazone", "serum sickness-like reactions" ], [ "phenylbutazone", "Skin manifestations" ] ]
CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.	[ [ "rifabutin", "corneal endothelial deposits" ] ]
This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.	[ [ "sodium warfarin", "myonecrosis" ], [ "sodium warfarin", "necrotizing fasciitis" ] ]
We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.	[ [ "PPA", "psychiatric adverse effects" ], [ "PPA", "paranoid psychosis" ] ]
Acceleration of ventricular response to atrial flutter after intravenous adenosine.	[ [ "adenosine", "Acceleration of ventricular response" ] ]
OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.	[ [ "hydroxyurea", "multiple squamous cell carcinomas" ], [ "hydroxyurea", "diffuse nail hyperpigmentation" ] ]
A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.	[ [ "methotrexate", "methotrexate toxicity" ], [ "methotrexate", "macrophage activation syndrome" ] ]
Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.	[ [ "penicillamine", "lupus erythematosus" ] ]
After discontinuation of danazol the diabetes completely resolved.	[ [ "danazol", "diabetes" ] ]
After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.	[ [ "sertraline", "intense itching sensation" ] ]
An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.	[ [ "penicillin", "JHR" ] ]
PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.	[ [ "rifabutin", "corneal endothelial deposits" ] ]
With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.	[ [ "Cyclosporine A", "herpes esophagitis" ] ]
Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.	[ [ "phenobarbital", "Severe hepatotoxicity" ] ]
Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.	[ [ "gentamicin", "Renal failure" ] ]
First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.	[ [ "olanzapine", "agranulocytosis" ], [ "Zyprexa", "agranulocytosis" ], [ "Zyprexa", "neutropenia" ], [ "olanzapine", "neutropenia" ] ]
Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.	[ [ "amodiaquine", "asymptomatic hepatitis" ], [ "artesunate", "asymptomatic hepatitis" ] ]
Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.	[ [ "6-thioguanine", "Hepatotoxicity" ] ]
He developed a late secondary infection in some sites treated with imiquimod.	[ [ "imiquimod", "secondary infection" ] ]
We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.	[ [ "lithium", "angry outbursts" ], [ "lithium", "irritability" ] ]
The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.	[ [ "para-aminosalicylic acid", "hypoglycaemic coma" ], [ "PAS", "hypoglycaemic coma" ] ]
A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.	[ [ "carbimazole", "fever" ], [ "carbimazole", "sore throat" ] ]
When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.	[ [ "amphotericin B", "severe side effects" ] ]
Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.	[ [ "chlorhexidine", "Metabolic acidosis" ], [ "cetrimide", "Metabolic acidosis" ] ]
Other upper tract neoplasms after cyclophosphamide are reviewed.	[ [ "cyclophosphamide", "upper tract neoplasms" ] ]
The cough continued for the duration of therapy with quinapril.	[ [ "quinapril", "cough" ] ]
A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.	[ [ "human growth hormone", "Creutzfeldt-Jakob disease" ] ]
It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.	[ [ "ergotamine", "fatal stroke" ], [ "ergotamine", "arterial spasm" ] ]
Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.	[ [ "amiodarone", "pulmonary toxicity" ] ]
We report a case of a bullous lichenoid eruption due to the intake of captopril.	[ [ "captopril", "bullous lichenoid eruption" ] ]
CASE SUMMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time.	[ [ "amphotericin B", "grand mal seizures" ] ]
Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.	[ [ "cephalosporin", "coagulopathy" ], [ "moxalactam", "coagulopathy" ] ]
The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement.	[ [ "benfluorex", "valvular heart disease" ] ]
Intravenous azithromycin-induced ototoxicity.	[ [ "azithromycin", "ototoxicity" ] ]
To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.	[ [ "MMI", "massive plasmocytosis" ], [ "MMI", "pancytopenia" ] ]
DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.	[ [ "mirtazapine", "SS" ] ]
A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.	[ [ "nifedipine", "dysphagia for solids" ] ]
After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.	[ [ "pentamidine", "heart rate had decreased" ] ]
Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.	[ [ "ATRA", "teratogenic effect" ] ]
Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.	[ [ "methylprednisolone", "myocardial infarction" ], [ "methylprednisolone", "severe hypertension" ] ]
Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.	[ [ "rituximab", "KS" ], [ "rituximab", "Kaposi's sarcoma" ] ]
Disulfiram encephalopathy as a cause of the catatonia syndrome.	[ [ "Disulfiram", "encephalopathy" ], [ "Disulfiram", "catatonia syndrome" ] ]
This eruption appears to be a distinct cutaneous toxicity of PLD.	[ [ "PLD", "eruption" ] ]
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.	[ [ "flupirtine", "Paradoxical cerebral cortical hyperexcitability" ] ]
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.	[ [ "L-dopa", "rapid mood cycling" ] ]
Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.	[ [ "ketamine", "urological symptoms" ] ]
We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.	[ [ "mesalamine", "acute pancreatitis" ] ]
However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.	[ [ "tPA", "vitreous hemorrhage" ] ]
Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.	[ [ "disulfiram", "significant abnormalities" ] ]
CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.	[ [ "bevacizumab", "Infectious endophthalmitis" ] ]
Ampicillin may aggravate clinical and experimental myasthenia gravis.	[ [ "Ampicillin", "myasthenia gravis" ] ]
Aripiprazole-induced hiccups: a case report.	[ [ "Aripiprazole", "hiccups" ] ]
OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.	[ [ "mirtazapine", "SS" ], [ "mirtazapine", "serotonin syndrome" ] ]
Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.	[ [ "aspirin", "RS" ] ]
Corneal edema recurred when the administration of amantadine was resumed.	[ [ "amantadine", "Corneal edema" ] ]
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.	[ [ "glibenclamide", "Intrahepatic cholestasis" ], [ "glibenclamide", "cutaneous bullae" ] ]
We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.	[ [ "interferon alpha 2b", "livedo reticularis" ] ]
We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.	[ [ "codeine", "codeine intoxication" ] ]
We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported.	[ [ "MTX", "neurotoxicity" ] ]
The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.	[ [ "propranolol", "abnormal rhythm" ] ]
Methimazole-associated cholestatic liver injury: case report and brief literature review.	[ [ "Methimazole", "cholestatic liver injury" ] ]
We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.	[ [ "BCNU", "pulmonary fibrosis" ] ]
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.	[ [ "adefovir", "hepatitis B infection" ], [ "lamivudine", "hepatitis B infection" ] ]

He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.

[ [ "clomipramine", "serotonin syndrome" ] ]

Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.

[ [ "imatinib mesylate", "blast crisis" ] ]

This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.

[ [ "fluvoxamine", "Schneiderian first-rank symptoms" ] ]

AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).

[ [ "Glypressin", "skin necrosis" ], [ "terlipressin", "skin necrosis" ] ]

Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.

[ [ "tamoxifen", "Gastric tumor" ], [ "tamoxifen", "endometrial carcinoma" ], [ "tamoxifen", "cervical adenocarcinoma" ] ]

Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.

[ [ "mitomycin", "hemolytic-uremic syndrome" ] ]

The most common complication of warfarin use is adverse bleeding.

[ [ "warfarin", "bleeding" ] ]

In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.

[ [ "halofantrine", "QT interval was prolonged" ] ]

We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.

[ [ "ivermectin", "severe hepatitis" ] ]

Development of tics in a thirteen-year-old male following atomoxetine use.

[ [ "atomoxetine", "tics" ] ]

CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.

[ [ "Alendronate", "nodular scleritis" ], [ "Alendronate", "scleritis" ] ]

However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.

[ [ "teicoplanin", "neutropenia" ] ]

A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.

[ [ "methotrexate", "toxic hepatitis" ], [ "etretinate", "toxic hepatitis" ] ]

Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.

[ [ "aspirin", "angioedema" ], [ "aspirin", "systemic anaphylactoid reaction" ], [ "aspirin", "urticaria" ] ]

The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.

[ [ "itraconazole", "tremor" ] ]

We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.

[ [ "foscarnet", "CMV infection" ], [ "ganciclovir", "CMV infection" ], [ "cidofovir", "CMV infection" ] ]

Quinine induced coagulopathy--a near fatal experience.

[ [ "Quinine", "coagulopathy" ] ]

We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.

[ [ "doxorubicin", "mucositis" ], [ "dexamethasone", "gastritis" ] ]

Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.

[ [ "heparin", "thrombosis" ] ]

Dyspnea possibly associated with controlled-release morphine sulfate tablets.

[ [ "morphine sulfate", "Dyspnea" ] ]

CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.

[ [ "gemcitabine", "HUS" ] ]

Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.

[ [ "ticlopidine", "pulmonary symptoms" ] ]

A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.

[ [ "capecitabine", "headache" ] ]

There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.

[ [ "liothyronine", "hyperthyroidism" ] ]

Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.

[ [ "lithium", "lithium intoxication" ], [ "lithium", "diabetes insipidus-like syndrome" ], [ "Lithium", "lithium intoxication" ], [ "Lithium", "diabetes insipidus-like syndrome" ] ]

Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.

[ [ "Captopril", "bone marrow suppression" ] ]

L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.

[ [ "valproic acid", "fatal hepatotoxic effects" ] ]

The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.

[ [ "thiabendazole", "cholestasis" ], [ "thiabendazole", "sicca complex" ] ]

BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.

[ [ "capecitabine", "Headaches" ] ]

These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.

[ [ "interferon alpha", "livedo reticularis" ] ]

Naproxen-associated sudden sensorineural hearing loss.

[ [ "Naproxen", "sudden sensorineural hearing loss" ] ]

We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.

[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "grand mal seizure" ] ]

Angioedema and maculopapular eruptions associated with carbamazepine administration.

[ [ "carbamazepine", "maculopapular eruptions" ], [ "carbamazepine", "Angioedema" ] ]

METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.

[ [ "imiquimod", "verrucous plaque" ] ]

We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.

[ [ "methanol", "cerebral edema" ], [ "methanol", "ventricular compression" ], [ "methanol", "diffuse brain involvement" ], [ "methanol", "bilateral putaminal necrosis" ], [ "methanol", "fatal" ], [ "methanol", "methanol toxicity" ] ]

We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.

[ [ "gemcitabine", "radiation-recall" ], [ "gemcitabine", "gastrointestinal bleeding" ] ]

Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.

[ [ "etoposide", "pulmonary toxicity" ] ]

Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.

[ [ "phenylbutazone", "serum sickness-like reactions" ], [ "phenylbutazone", "Skin manifestations" ] ]

CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.

[ [ "rifabutin", "corneal endothelial deposits" ] ]

This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.

[ [ "sodium warfarin", "myonecrosis" ], [ "sodium warfarin", "necrotizing fasciitis" ] ]

We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.

[ [ "PPA", "psychiatric adverse effects" ], [ "PPA", "paranoid psychosis" ] ]

Acceleration of ventricular response to atrial flutter after intravenous adenosine.

[ [ "adenosine", "Acceleration of ventricular response" ] ]

OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.

[ [ "hydroxyurea", "multiple squamous cell carcinomas" ], [ "hydroxyurea", "diffuse nail hyperpigmentation" ] ]

A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.

[ [ "methotrexate", "methotrexate toxicity" ], [ "methotrexate", "macrophage activation syndrome" ] ]

Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.

[ [ "penicillamine", "lupus erythematosus" ] ]

After discontinuation of danazol the diabetes completely resolved.

[ [ "danazol", "diabetes" ] ]

After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.

[ [ "sertraline", "intense itching sensation" ] ]

An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.

[ [ "penicillin", "JHR" ] ]

PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.

[ [ "rifabutin", "corneal endothelial deposits" ] ]

With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.

[ [ "Cyclosporine A", "herpes esophagitis" ] ]

Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.

[ [ "phenobarbital", "Severe hepatotoxicity" ] ]

Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.

[ [ "gentamicin", "Renal failure" ] ]

First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.

[ [ "olanzapine", "agranulocytosis" ], [ "Zyprexa", "agranulocytosis" ], [ "Zyprexa", "neutropenia" ], [ "olanzapine", "neutropenia" ] ]

Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.

[ [ "amodiaquine", "asymptomatic hepatitis" ], [ "artesunate", "asymptomatic hepatitis" ] ]

Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.

[ [ "6-thioguanine", "Hepatotoxicity" ] ]

He developed a late secondary infection in some sites treated with imiquimod.

[ [ "imiquimod", "secondary infection" ] ]

We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.

[ [ "lithium", "angry outbursts" ], [ "lithium", "irritability" ] ]

The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.

[ [ "para-aminosalicylic acid", "hypoglycaemic coma" ], [ "PAS", "hypoglycaemic coma" ] ]

A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.

[ [ "carbimazole", "fever" ], [ "carbimazole", "sore throat" ] ]

When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.

[ [ "amphotericin B", "severe side effects" ] ]

Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.

[ [ "chlorhexidine", "Metabolic acidosis" ], [ "cetrimide", "Metabolic acidosis" ] ]

Other upper tract neoplasms after cyclophosphamide are reviewed.

[ [ "cyclophosphamide", "upper tract neoplasms" ] ]

The cough continued for the duration of therapy with quinapril.

[ [ "quinapril", "cough" ] ]

A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.

[ [ "human growth hormone", "Creutzfeldt-Jakob disease" ] ]

It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.

[ [ "ergotamine", "fatal stroke" ], [ "ergotamine", "arterial spasm" ] ]

Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.

[ [ "amiodarone", "pulmonary toxicity" ] ]

We report a case of a bullous lichenoid eruption due to the intake of captopril.

[ [ "captopril", "bullous lichenoid eruption" ] ]

CASE SUMMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time.

[ [ "amphotericin B", "grand mal seizures" ] ]

Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.

[ [ "cephalosporin", "coagulopathy" ], [ "moxalactam", "coagulopathy" ] ]

The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement.

[ [ "benfluorex", "valvular heart disease" ] ]

Intravenous azithromycin-induced ototoxicity.

[ [ "azithromycin", "ototoxicity" ] ]

To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.

[ [ "MMI", "massive plasmocytosis" ], [ "MMI", "pancytopenia" ] ]

DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.

[ [ "mirtazapine", "SS" ] ]

A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.

[ [ "nifedipine", "dysphagia for solids" ] ]

After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.

[ [ "pentamidine", "heart rate had decreased" ] ]

Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.

[ [ "ATRA", "teratogenic effect" ] ]

Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.

[ [ "methylprednisolone", "myocardial infarction" ], [ "methylprednisolone", "severe hypertension" ] ]

Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.

[ [ "rituximab", "KS" ], [ "rituximab", "Kaposi's sarcoma" ] ]

Disulfiram encephalopathy as a cause of the catatonia syndrome.

[ [ "Disulfiram", "encephalopathy" ], [ "Disulfiram", "catatonia syndrome" ] ]

This eruption appears to be a distinct cutaneous toxicity of PLD.

[ [ "PLD", "eruption" ] ]

Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.

[ [ "flupirtine", "Paradoxical cerebral cortical hyperexcitability" ] ]

Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.

[ [ "L-dopa", "rapid mood cycling" ] ]

Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.

[ [ "ketamine", "urological symptoms" ] ]

We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.

[ [ "mesalamine", "acute pancreatitis" ] ]

However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.

[ [ "tPA", "vitreous hemorrhage" ] ]

Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.

[ [ "disulfiram", "significant abnormalities" ] ]

CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.

[ [ "bevacizumab", "Infectious endophthalmitis" ] ]

Ampicillin may aggravate clinical and experimental myasthenia gravis.

[ [ "Ampicillin", "myasthenia gravis" ] ]

Aripiprazole-induced hiccups: a case report.

[ [ "Aripiprazole", "hiccups" ] ]

OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.

[ [ "mirtazapine", "SS" ], [ "mirtazapine", "serotonin syndrome" ] ]

Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.

[ [ "aspirin", "RS" ] ]

Corneal edema recurred when the administration of amantadine was resumed.

[ [ "amantadine", "Corneal edema" ] ]

Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.

[ [ "glibenclamide", "Intrahepatic cholestasis" ], [ "glibenclamide", "cutaneous bullae" ] ]

We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.

[ [ "interferon alpha 2b", "livedo reticularis" ] ]

We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.

[ [ "codeine", "codeine intoxication" ] ]

We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported.

[ [ "MTX", "neurotoxicity" ] ]

The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.

[ [ "propranolol", "abnormal rhythm" ] ]

Methimazole-associated cholestatic liver injury: case report and brief literature review.

[ [ "Methimazole", "cholestatic liver injury" ] ]

We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.

[ [ "BCNU", "pulmonary fibrosis" ] ]

Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.

[ [ "adefovir", "hepatitis B infection" ], [ "lamivudine", "hepatitis B infection" ] ]