harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.	[ [ "sulfamethoxazole", "hemolytic anemia" ], [ "trimethoprim", "orthostatic hypotension" ], [ "sulfamethoxazole", "hepatitis" ], [ "sulfamethoxazole", "aseptic meningitis" ], [ "trimethoprim", "hepatitis" ], [ "sulfamethoxazole", "orthostatic hypotension" ], [ "trimethoprim", "hemolytic anemia" ], [ "trimethoprim", "aseptic meningitis" ] ]
The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.	[ [ "MTX", "anaphylactic reactions" ] ]
Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.	[ [ "cyanamide", "elevation of serum transaminases" ] ]
In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.	[ [ "olanzapine", "akathisia" ] ]
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.	[ [ "Olanzapine", "hyperglycaemic coma" ], [ "Olanzapine", "neuroleptic malignant syndrome" ] ]
A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.	[ [ "disodium cromoglycate", "moderately severe bronchospasm" ], [ "disodium cromoglycate", "urticarial rash" ] ]
Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.	[ [ "sulfadiazine", "hypersensitivity" ] ]
These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.	[ [ "olanzapine", "agranulocytosis" ], [ "olanzapine", "leukopenia" ] ]
Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.	[ [ "Infliximab", "lupus-like syndrome" ] ]
Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.	[ [ "Methotrexate", "nephropathy" ] ]
This is the first reported case of hepatolithiasis during octreotide therapy.	[ [ "octreotide", "hepatolithiasis" ] ]
RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.	[ [ "amantadine", "bilateral corneal edema" ] ]
Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.	[ [ "hydroxychloroquine", "retinopathy" ] ]
CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.	[ [ "gabapentin", "renal impairment" ] ]
Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.	[ [ "gemcitabine", "Radiation recall" ] ]
We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.	[ [ "cyclophosphamide", "porphyria cutanea tarda" ], [ "cisplatin", "porphyria cutanea tarda" ] ]
RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.	[ [ "rofecoxib", "IBD" ], [ "rofecoxib", "inflammatory bowel disease" ] ]
Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.	[ [ "leflunomide", "Syringotropic hypersensitivity reaction" ], [ "infliximab", "Syringotropic hypersensitivity reaction" ] ]
The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.	[ [ "phenolphthalein", "TEN" ], [ "phenolphthalein", "rash" ] ]
METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.	[ [ "budesonide", "contact dermatitis" ] ]
Cardiac arrest following use of sumatriptan.	[ [ "sumatriptan", "Cardiac arrest" ] ]
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).	[ [ "HDMTX", "renal failure" ], [ "methotrexate", "renal failure" ] ]
There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.	[ [ "olanzapine", "hyperglycemia" ] ]
Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.	[ [ "clozapine", "Akathisia" ] ]
Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.	[ [ "formalin", "Fatal complication" ] ]
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.	[ [ "imipenem", "seizures" ], [ "cilastatin", "seizures" ] ]
Lithium-induced Creutzfeldt-Jakob syndrome.	[ [ "Lithium", "Creutzfeldt-Jakob syndrome" ] ]
Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.	[ [ "amoxapine", "dyskinesia" ] ]
The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.	[ [ "phenytoin", "lymphadenopathy" ], [ "phenytoin", "rash" ], [ "phenytoin", "fever" ], [ "phenytoin", "hypersensitivity reactions" ] ]
Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.	[ [ "chlorpromazine", "symptoms resembling Parkinson's disease" ] ]
We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.	[ [ "trimethoprim", "Thrombotic Thrombocytopenic Purpura" ], [ "sulfamethoxazole", "Thrombotic Thrombocytopenic Purpura" ] ]
We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.	[ [ "lidocaine", "pupillary mydriasis" ] ]
Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).	[ [ "sertraline", "Extrapyramidal side effects" ], [ "fluoxetine", "Extrapyramidal side effects" ] ]
The mean time from starting MMF to the development of neutropenia was 4 months.	[ [ "MMF", "neutropenia" ] ]
Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.	[ [ "cyclosporine A", "fall of the filtration fraction" ], [ "cyclosporine A", "nephrotoxicity" ], [ "cyclosporine A", "rise in the relative clearance of 99Tc-dimercaptosuccinic acid" ], [ "cyclosporine A", "increase in proteinuria" ] ]
Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.	[ [ "propranolol", "Alternating sinus rhythm" ], [ "propranolol", "intermittent sinoatrial (S-A) block" ] ]
Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).	[ [ "leflunomide", "gastroenteritis" ], [ "leflunomide", "abdominal sepsis" ], [ "leflunomide", "infection" ], [ "leflunomide", "lower respiratory tract infections" ], [ "leflunomide", "cellulitis" ], [ "leflunomide", "mycotic aneurysm" ], [ "leflunomide", "disseminated herpes zoster" ], [ "leflunomide", "TB liver" ] ]
OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.	[ [ "cisplatin", "anaphylactoid reactions" ] ]
Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.	[ [ "thalidomide", "fever" ], [ "thalidomide", "pulmonary infiltrates" ] ]
Hepatitis following cimetidine administration.	[ [ "cimetidine", "Hepatitis" ] ]
OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.	[ [ "lovastatin", "rhabdomyolysis" ], [ "clarithromycin", "rhabdomyolysis" ], [ "azithromycin", "rhabdomyolysis" ] ]
Easily reversible hypoxemia and hypotension induced by nimodipine.	[ [ "nimodipine", "hypotension" ], [ "nimodipine", "hypoxemia" ] ]
The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.	[ [ "cyclophosphamide", "severe restrictive ventilatory defect" ] ]
A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis.	[ [ "glatiramer acetate", "ECM" ] ]
We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.	[ [ "rituximab", "autoimmune hemolytic anemia" ] ]
Poorly controlled hypertension in a painter with chronic lead toxicity.	[ [ "lead", "lead toxicity" ] ]
CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.	[ [ "methylphenidate", "Fixed drug rash" ] ]
Hypersensitivity to zonisamide was confirmed by the skin patch test.	[ [ "zonisamide", "Hypersensitivity" ] ]
A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.	[ [ "pranlukast", "interstitial pneumonitis" ], [ "pranlukast", "high fever" ] ]
Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.	[ [ "gemcitabine", "Severe hemolytic uremic syndrome" ], [ "carboplatin", "Severe hemolytic uremic syndrome" ] ]
In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.	[ [ "busulfan", "hepatic veno-occlusive disease" ], [ "busulfan", "thrombosis" ], [ "busulfan", "HVOD" ] ]
Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.	[ [ "procainamide", "reversible granulocytopenia" ] ]
We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.	[ [ "cisplatin", "renal tubular salt wasting" ] ]
An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.	[ [ "acetazolamide", "severe acidosis" ] ]
BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.	[ [ "Fluoxetine", "sexual dysfunction" ] ]
Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.	[ [ "levamisole", "leukoencephalopathy" ], [ "5-fluorouracil", "leukoencephalopathy" ] ]
Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.	[ [ "propylthiouracil", "Fulminant hepatic failure" ], [ "propranolol", "Fulminant hepatic failure" ] ]
A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.	[ [ "magnesium", "protracted neuromuscular block" ], [ "vecuronium", "protracted neuromuscular block" ] ]
A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.	[ [ "BCNU", "fatal pulmonary fibrosis" ] ]
CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.	[ [ "olanzapine", "hyperglycemia" ] ]
A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.	[ [ "minocycline", "chills" ], [ "minocycline", "night sweats" ], [ "minocycline", "generalized, pruritic, macular eruption" ], [ "minocycline", "fatigue" ], [ "minocycline", "fever" ] ]
Severe apnea in an infant exposed to lamotrigine in breast milk.	[ [ "lamotrigine", "Severe apnea" ] ]
The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.	[ [ "foscarnet", "muscle twitches" ], [ "foscarnet", "anxiety" ], [ "foscarnet", "tremulousness" ] ]
Nail staining from hydroquinone cream.	[ [ "hydroquinone", "Nail staining" ] ]
We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.	[ [ "penicillin", "acute blistering eruption" ] ]
CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.	[ [ "carboplatin", "hypersensitivity" ] ]
A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.	[ [ "amiodarone", "acute hepatitis" ] ]
Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.	[ [ "Recombinant human interferon-alpha", "exacerbate psoriasis or trigger off its onset" ] ]
The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.	[ [ "captopril", "acute renal failure" ] ]
Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.	[ [ "Diphenhydramine", "dysrhythmia" ] ]
Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.	[ [ "chlorambucil", "balanced translocation" ] ]
This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.	[ [ "prochlorperazine", "oro-pharyngeal dystonic reaction" ], [ "prochlorperazine", "epiglottitis" ] ]
Uncontrolled headache induced by oxcarbazepine.	[ [ "oxcarbazepine", "headache" ] ]
Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.	[ [ "amantadine", "psychotic decompensations" ] ]
Human insulin-induced lipoatrophy.	[ [ "Human insulin", "lipoatrophy" ] ]
During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.	[ [ "carbamazepine", "ataxia" ], [ "clarithromycin", "toxic symptoms" ], [ "carbamazepine", "dizziness" ], [ "carbamazepine", "drowsiness" ], [ "carbamazepine", "toxic symptoms" ], [ "clarithromycin", "dizziness" ], [ "clarithromycin", "ataxia" ], [ "clarithromycin", "drowsiness" ] ]
This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.	[ [ "rituximab", "BOOP" ] ]
Acute renal failure should be recognized as a potential complication of suramin treatment.	[ [ "suramin", "renal failure" ] ]
OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.	[ [ "Dantrolene", "Carbamazepine toxicity" ], [ "Oxybutynin", "Carbamazepine toxicity" ], [ "Carbamazepine", "Carbamazepine toxicity" ] ]
Insulin-dependent diabetes mellitus associated with danazol.	[ [ "danazol", "Insulin-dependent diabetes mellitus" ] ]
Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.	[ [ "FUdR", "Neurologic toxicity" ] ]
Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.	[ [ "methotrexate", "intracranial mass lesion" ], [ "methotrexate", "Transtentorial herniation" ] ]
CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.	[ [ "fludarabine phosphate", "CD4 T-lymphocyte depletion" ], [ "fludarabine phosphate", "myelosuppression" ], [ "fludarabine phosphate", "severe infections" ] ]
Amifostine-induced fever: case report and review of the literature.	[ [ "Amifostine", "fever" ] ]
Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.	[ [ "clonidine", "dry mouth" ], [ "clonidine", "bradycardia" ], [ "clonidine", "constipation" ], [ "clonidine", "hypotension" ] ]
Our experience supports hemodialysis for ESRF patients with atenolol toxicity.	[ [ "atenolol", "atenolol toxicity" ] ]
DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.	[ [ "leflunomide", "liver enzyme elevation" ], [ "leflunomide", "alopecia" ], [ "leflunomide", "hypertension" ], [ "leflunomide", "nausea" ], [ "leflunomide", "allergic skin reactions" ], [ "leflunomide", "diarrhea" ] ]
Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.	[ [ "ritonavir", "Transient cardiac arrhythmias" ], [ "lopinavir", "Transient cardiac arrhythmias" ] ]
We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.	[ [ "5-FU", "life-threatening toxicity" ] ]
Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.	[ [ "Metoclopramide", "parkinsonism" ] ]
In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.	[ [ "ciprofloxacin", "prolonged ECT seizure" ] ]
We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.	[ [ "cyclophosphamide", "NEH" ] ]
To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.	[ [ "irbesartan", "shock" ], [ "irbesartan", "angio-oedema" ] ]
Renal failure associated with the use of dextran-40.	[ [ "dextran-40", "Renal failure" ] ]
We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.	[ [ "vancomycin", "CSFE" ], [ "vancomycin", "cerebrospinal fluid eosinophilia" ] ]
Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.	[ [ "aspirin", "Intracranial haemorrhage" ] ]
CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.	[ [ "baclofen", "impair sexual function" ] ]
Rifampin-associated thrombocytopenia secondary to poor compliance.	[ [ "Rifampin", "thrombocytopenia" ] ]
Introduction of etanercept was also clinically effective but followed by development of severe heart failure.	[ [ "etanercept", "severe heart failure" ] ]
The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.	[ [ "clozapine", "sudden death" ] ]

CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.

[ [ "sulfamethoxazole", "hemolytic anemia" ], [ "trimethoprim", "orthostatic hypotension" ], [ "sulfamethoxazole", "hepatitis" ], [ "sulfamethoxazole", "aseptic meningitis" ], [ "trimethoprim", "hepatitis" ], [ "sulfamethoxazole", "orthostatic hypotension" ], [ "trimethoprim", "hemolytic anemia" ], [ "trimethoprim", "aseptic meningitis" ] ]

The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.

[ [ "MTX", "anaphylactic reactions" ] ]

Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.

[ [ "cyanamide", "elevation of serum transaminases" ] ]

In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.

[ [ "olanzapine", "akathisia" ] ]

Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.

[ [ "Olanzapine", "hyperglycaemic coma" ], [ "Olanzapine", "neuroleptic malignant syndrome" ] ]

A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.

[ [ "disodium cromoglycate", "moderately severe bronchospasm" ], [ "disodium cromoglycate", "urticarial rash" ] ]

Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.

[ [ "sulfadiazine", "hypersensitivity" ] ]

These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.

[ [ "olanzapine", "agranulocytosis" ], [ "olanzapine", "leukopenia" ] ]

Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.

[ [ "Infliximab", "lupus-like syndrome" ] ]

Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.

[ [ "Methotrexate", "nephropathy" ] ]

This is the first reported case of hepatolithiasis during octreotide therapy.

[ [ "octreotide", "hepatolithiasis" ] ]

RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.

[ [ "amantadine", "bilateral corneal edema" ] ]

Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.

[ [ "hydroxychloroquine", "retinopathy" ] ]

CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.

[ [ "gabapentin", "renal impairment" ] ]

Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.

[ [ "gemcitabine", "Radiation recall" ] ]

We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.

[ [ "cyclophosphamide", "porphyria cutanea tarda" ], [ "cisplatin", "porphyria cutanea tarda" ] ]

RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.

[ [ "rofecoxib", "IBD" ], [ "rofecoxib", "inflammatory bowel disease" ] ]

Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.

[ [ "leflunomide", "Syringotropic hypersensitivity reaction" ], [ "infliximab", "Syringotropic hypersensitivity reaction" ] ]

The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.

[ [ "phenolphthalein", "TEN" ], [ "phenolphthalein", "rash" ] ]

METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.

[ [ "budesonide", "contact dermatitis" ] ]

Cardiac arrest following use of sumatriptan.

[ [ "sumatriptan", "Cardiac arrest" ] ]

We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).

[ [ "HDMTX", "renal failure" ], [ "methotrexate", "renal failure" ] ]

There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.

[ [ "olanzapine", "hyperglycemia" ] ]

Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.

[ [ "clozapine", "Akathisia" ] ]

Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.

[ [ "formalin", "Fatal complication" ] ]

Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.

[ [ "imipenem", "seizures" ], [ "cilastatin", "seizures" ] ]

Lithium-induced Creutzfeldt-Jakob syndrome.

[ [ "Lithium", "Creutzfeldt-Jakob syndrome" ] ]

Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.

[ [ "amoxapine", "dyskinesia" ] ]

The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.

[ [ "phenytoin", "lymphadenopathy" ], [ "phenytoin", "rash" ], [ "phenytoin", "fever" ], [ "phenytoin", "hypersensitivity reactions" ] ]

Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.

[ [ "chlorpromazine", "symptoms resembling Parkinson's disease" ] ]

We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.

[ [ "trimethoprim", "Thrombotic Thrombocytopenic Purpura" ], [ "sulfamethoxazole", "Thrombotic Thrombocytopenic Purpura" ] ]

We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.

[ [ "lidocaine", "pupillary mydriasis" ] ]

Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).

[ [ "sertraline", "Extrapyramidal side effects" ], [ "fluoxetine", "Extrapyramidal side effects" ] ]

The mean time from starting MMF to the development of neutropenia was 4 months.

[ [ "MMF", "neutropenia" ] ]

Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.

[ [ "cyclosporine A", "fall of the filtration fraction" ], [ "cyclosporine A", "nephrotoxicity" ], [ "cyclosporine A", "rise in the relative clearance of 99Tc-dimercaptosuccinic acid" ], [ "cyclosporine A", "increase in proteinuria" ] ]

Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.

[ [ "propranolol", "Alternating sinus rhythm" ], [ "propranolol", "intermittent sinoatrial (S-A) block" ] ]

Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).

[ [ "leflunomide", "gastroenteritis" ], [ "leflunomide", "abdominal sepsis" ], [ "leflunomide", "infection" ], [ "leflunomide", "lower respiratory tract infections" ], [ "leflunomide", "cellulitis" ], [ "leflunomide", "mycotic aneurysm" ], [ "leflunomide", "disseminated herpes zoster" ], [ "leflunomide", "TB liver" ] ]

OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.

[ [ "cisplatin", "anaphylactoid reactions" ] ]

Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.

[ [ "thalidomide", "fever" ], [ "thalidomide", "pulmonary infiltrates" ] ]

Hepatitis following cimetidine administration.

[ [ "cimetidine", "Hepatitis" ] ]

OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.

[ [ "lovastatin", "rhabdomyolysis" ], [ "clarithromycin", "rhabdomyolysis" ], [ "azithromycin", "rhabdomyolysis" ] ]

Easily reversible hypoxemia and hypotension induced by nimodipine.

[ [ "nimodipine", "hypotension" ], [ "nimodipine", "hypoxemia" ] ]

The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.

[ [ "cyclophosphamide", "severe restrictive ventilatory defect" ] ]

A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis.

[ [ "glatiramer acetate", "ECM" ] ]

We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.

[ [ "rituximab", "autoimmune hemolytic anemia" ] ]

Poorly controlled hypertension in a painter with chronic lead toxicity.

[ [ "lead", "lead toxicity" ] ]

CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.

[ [ "methylphenidate", "Fixed drug rash" ] ]

Hypersensitivity to zonisamide was confirmed by the skin patch test.

[ [ "zonisamide", "Hypersensitivity" ] ]

A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.

[ [ "pranlukast", "interstitial pneumonitis" ], [ "pranlukast", "high fever" ] ]

Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.

[ [ "gemcitabine", "Severe hemolytic uremic syndrome" ], [ "carboplatin", "Severe hemolytic uremic syndrome" ] ]

In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.

[ [ "busulfan", "hepatic veno-occlusive disease" ], [ "busulfan", "thrombosis" ], [ "busulfan", "HVOD" ] ]

Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.

[ [ "procainamide", "reversible granulocytopenia" ] ]

We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.

[ [ "cisplatin", "renal tubular salt wasting" ] ]

An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.

[ [ "acetazolamide", "severe acidosis" ] ]

BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.

[ [ "Fluoxetine", "sexual dysfunction" ] ]

Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.

[ [ "levamisole", "leukoencephalopathy" ], [ "5-fluorouracil", "leukoencephalopathy" ] ]

Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.

[ [ "propylthiouracil", "Fulminant hepatic failure" ], [ "propranolol", "Fulminant hepatic failure" ] ]

A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.

[ [ "magnesium", "protracted neuromuscular block" ], [ "vecuronium", "protracted neuromuscular block" ] ]

A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.

[ [ "BCNU", "fatal pulmonary fibrosis" ] ]

CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.

[ [ "olanzapine", "hyperglycemia" ] ]

A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.

[ [ "minocycline", "chills" ], [ "minocycline", "night sweats" ], [ "minocycline", "generalized, pruritic, macular eruption" ], [ "minocycline", "fatigue" ], [ "minocycline", "fever" ] ]

Severe apnea in an infant exposed to lamotrigine in breast milk.

[ [ "lamotrigine", "Severe apnea" ] ]

The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.

[ [ "foscarnet", "muscle twitches" ], [ "foscarnet", "anxiety" ], [ "foscarnet", "tremulousness" ] ]

Nail staining from hydroquinone cream.

[ [ "hydroquinone", "Nail staining" ] ]

We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.

[ [ "penicillin", "acute blistering eruption" ] ]

CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.

[ [ "carboplatin", "hypersensitivity" ] ]

A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.

[ [ "amiodarone", "acute hepatitis" ] ]

Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.

[ [ "Recombinant human interferon-alpha", "exacerbate psoriasis or trigger off its onset" ] ]

The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.

[ [ "captopril", "acute renal failure" ] ]

Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.

[ [ "Diphenhydramine", "dysrhythmia" ] ]

Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.

[ [ "chlorambucil", "balanced translocation" ] ]

This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.

[ [ "prochlorperazine", "oro-pharyngeal dystonic reaction" ], [ "prochlorperazine", "epiglottitis" ] ]

Uncontrolled headache induced by oxcarbazepine.

[ [ "oxcarbazepine", "headache" ] ]

Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.

[ [ "amantadine", "psychotic decompensations" ] ]

Human insulin-induced lipoatrophy.

[ [ "Human insulin", "lipoatrophy" ] ]

During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.

[ [ "carbamazepine", "ataxia" ], [ "clarithromycin", "toxic symptoms" ], [ "carbamazepine", "dizziness" ], [ "carbamazepine", "drowsiness" ], [ "carbamazepine", "toxic symptoms" ], [ "clarithromycin", "dizziness" ], [ "clarithromycin", "ataxia" ], [ "clarithromycin", "drowsiness" ] ]

This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.

[ [ "rituximab", "BOOP" ] ]

Acute renal failure should be recognized as a potential complication of suramin treatment.

[ [ "suramin", "renal failure" ] ]

OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.

[ [ "Dantrolene", "Carbamazepine toxicity" ], [ "Oxybutynin", "Carbamazepine toxicity" ], [ "Carbamazepine", "Carbamazepine toxicity" ] ]

Insulin-dependent diabetes mellitus associated with danazol.

[ [ "danazol", "Insulin-dependent diabetes mellitus" ] ]

Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.

[ [ "FUdR", "Neurologic toxicity" ] ]

Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.

[ [ "methotrexate", "intracranial mass lesion" ], [ "methotrexate", "Transtentorial herniation" ] ]

CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.

[ [ "fludarabine phosphate", "CD4 T-lymphocyte depletion" ], [ "fludarabine phosphate", "myelosuppression" ], [ "fludarabine phosphate", "severe infections" ] ]

Amifostine-induced fever: case report and review of the literature.

[ [ "Amifostine", "fever" ] ]

Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.

[ [ "clonidine", "dry mouth" ], [ "clonidine", "bradycardia" ], [ "clonidine", "constipation" ], [ "clonidine", "hypotension" ] ]

Our experience supports hemodialysis for ESRF patients with atenolol toxicity.

[ [ "atenolol", "atenolol toxicity" ] ]

DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.

[ [ "leflunomide", "liver enzyme elevation" ], [ "leflunomide", "alopecia" ], [ "leflunomide", "hypertension" ], [ "leflunomide", "nausea" ], [ "leflunomide", "allergic skin reactions" ], [ "leflunomide", "diarrhea" ] ]

Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.

[ [ "ritonavir", "Transient cardiac arrhythmias" ], [ "lopinavir", "Transient cardiac arrhythmias" ] ]

We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.

[ [ "5-FU", "life-threatening toxicity" ] ]

Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.

[ [ "Metoclopramide", "parkinsonism" ] ]

In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.

[ [ "ciprofloxacin", "prolonged ECT seizure" ] ]

We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.

[ [ "cyclophosphamide", "NEH" ] ]

To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.

[ [ "irbesartan", "shock" ], [ "irbesartan", "angio-oedema" ] ]

Renal failure associated with the use of dextran-40.

[ [ "dextran-40", "Renal failure" ] ]

We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.

[ [ "vancomycin", "CSFE" ], [ "vancomycin", "cerebrospinal fluid eosinophilia" ] ]

Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.

[ [ "aspirin", "Intracranial haemorrhage" ] ]

CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.

[ [ "baclofen", "impair sexual function" ] ]

Rifampin-associated thrombocytopenia secondary to poor compliance.

[ [ "Rifampin", "thrombocytopenia" ] ]

Introduction of etanercept was also clinically effective but followed by development of severe heart failure.

[ [ "etanercept", "severe heart failure" ] ]

The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.

[ [ "clozapine", "sudden death" ] ]