harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.	[ [ "risperidone", "hypothermia" ] ]
The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.	[ [ "PGE1", "gastric mucosa foveolar hyperplasia" ] ]
We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.	[ [ "cyclophosphamide", "hepatic angiosarcoma" ] ]
We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.	[ [ "cytarabine", "bullous eruption" ], [ "cytarabine", "PPE" ] ]
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.	[ [ "calcium polystyrene sulfonate", "colonic ulcer" ], [ "calcium polystyrene sulfonate", "sigmoidovesical fistula" ], [ "sorbitol", "sigmoidovesical fistula" ], [ "sorbitol", "colonic ulcer" ] ]
These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.	[ [ "M-CSF", "macrophage-related glomerular injury" ] ]
It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.	[ [ "sulfasalazine", "serositis" ], [ "sulfasalazine", "pulmonary parenchymal involvement" ], [ "sulfasalazine", "lupus" ] ]
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).	[ [ "azathioprine", "Prenatal cytomegalovirus (CMV) infection" ], [ "azathioprine", "brain damage" ], [ "prednisolone", "Prenatal cytomegalovirus (CMV) infection" ], [ "prednisolone", "brain damage" ] ]
Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.	[ [ "amphotericin B", "cardiac arrhythmia" ] ]
A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.	[ [ "dapsone", "agranulocytosis" ] ]
This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.	[ [ "methotrexate", "acute myelocytic leukemia" ], [ "cyclophosphamide", "acute myelocytic leukemia" ], [ "5-fluorouracil", "acute myelocytic leukemia" ] ]
A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.	[ [ "pioglitazone", "bilateral lower leg edema" ] ]
A case of pyridoxine-dependent seizures is reported.	[ [ "pyridoxine", "seizures" ] ]
Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.	[ [ "DCF", "superinfection" ], [ "DCF", "immunosuppression" ] ]
After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.	[ [ "cyclosporine A", "loss of glomerular filtration rate" ], [ "cyclosporine A", "effective renal plasma flow" ] ]
We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.	[ [ "venlafaxine", "acute myocardial ischaemia" ] ]
Severe bleomycin lung toxicity: reversal with high dose corticosteroids.	[ [ "bleomycin", "lung toxicity" ] ]
During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.	[ [ "ethambutol", "visual loss" ] ]
Pulmonary gold toxicity.	[ [ "gold", "Pulmonary gold toxicity" ] ]
A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.	[ [ "colchicine", "leg weakness" ], [ "colchicine", "fatigue" ], [ "colchicine", "myalgia" ] ]
Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.	[ [ "erlotinib", "Fatal interstitial lung disease" ] ]
Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.	[ [ "octreotide", "intrahepatic bile stasis" ] ]
Thus, the patient's clinical course and workup strongly support a diagnosis of lenalidomide-induced hypersensitivity pneumonitis-like syndrome.	[ [ "lenalidomide", "hypersensitivity pneumonitis-like syndrome" ] ]
A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).	[ [ "methotrexate", "severe skin rash" ], [ "methotrexate", "bone marrow aplasia" ], [ "MTX", "severe skin rash" ], [ "MTX", "bone marrow aplasia" ] ]
A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.	[ [ "deanol", "tardive dyskinesia" ] ]
Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.	[ [ "methotrexate", "hypoxia" ], [ "methotrexate", "Pneumocystis pneumonia" ], [ "methotrexate", "fever" ], [ "methotrexate", "pulmonary infiltrates" ] ]
Mycophenolate mofetil-induced neutropenia in liver transplantation.	[ [ "Mycophenolate mofetil", "neutropenia" ] ]
Acute renal failure in a child associated with acyclovir.	[ [ "acyclovir", "Acute renal failure" ] ]
Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.	[ [ "amifostine", "anaphylactoid reaction" ] ]
We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.	[ [ "CBZ", "facial motor tics" ] ]
In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.	[ [ "piroxicam", "ulcers" ] ]
Apparent central nervous system depression in infants after the use of topical brimonidine.	[ [ "brimonidine", "central nervous system depression" ] ]
The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.	[ [ "clozapine", "hypersensitivity myocarditis" ] ]
Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.	[ [ "ritodrine", "Mobitz type I" ], [ "ritodrine", "Wenckebach AV block" ], [ "ritodrine", "Type I second-degree AV block" ] ]
Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.	[ [ "quinine", "amblyopia" ], [ "quinine", "Abnormalities of the pupil" ] ]
After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.	[ [ "argatroban", "bleeding" ] ]
However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.	[ [ "diphenhydramine", "cardiac toxicity" ] ]
BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.	[ [ "sirolimus", "Aphthous stomatitis" ] ]
We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.	[ [ "cyclosporin", "eye movement abnormality" ], [ "cyclosporin", "transient brain stem or neuromuscular dysfunction" ], [ "ganciclovir", "eye movement abnormality" ], [ "ganciclovir", "transient brain stem or neuromuscular dysfunction" ] ]
We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.	[ [ "5-FU", "severe mucositis" ], [ "5-FU", "prolonged myelosuppression" ], [ "5-FU", "neurologic toxicity" ] ]
Eruptive epidermoid cysts resulting from treatment with imiquimod.	[ [ "imiquimod", "Eruptive epidermoid cysts" ] ]
A retrospective study was conducted of 40 loperamide poisoning cases recorded at the Centre National d'Informations Toxicologiques Veterinaires.	[ [ "loperamide", "loperamide poisoning" ] ]
Asterixis induced by carbamazepine therapy.	[ [ "carbamazepine", "Asterixis" ] ]
One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.	[ [ "propranolol", "lower average mean blood pressure" ], [ "propranolol", "lower average heart rate" ] ]
We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.	[ [ "PCC", "MI" ] ]
Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.	[ [ "ribavirin", "diabetes mellitus" ], [ "interferon-alfa", "diabetes mellitus" ] ]
This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.	[ [ "mianserin", "panic anxiety" ] ]
Delusional parasitosis associated with phenelzine.	[ [ "phenelzine", "Delusional parasitosis" ] ]
Colchicine-induced myopathy in a teenager with familial Mediterranean fever.	[ [ "Colchicine", "myopathy" ] ]
We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.	[ [ "leflunomide", "hemoptysis" ], [ "leflunomide", "short-of-breath" ], [ "leflunomide", "severe weakness" ] ]
Phenylpropanolamine-induced psychosis.	[ [ "Phenylpropanolamine", "psychosis" ] ]
This confirmed the history of captopril-related asthma.	[ [ "captopril", "asthma" ] ]
Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).	[ [ "amiodarone", "thyrotropin-binding inhibiting immunoglobulin" ], [ "amiodarone", "thyrotoxicosis" ], [ "amiodarone", "transiently positive thyrotropin (TSH) receptor antibody" ] ]
To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.	[ [ "griseofulvin", "lupus" ], [ "griseofulvin", "nephrotic syndrome" ] ]
Disulfiram-induced fulminant hepatic failure in an active duty soldier.	[ [ "Disulfiram", "fulminant hepatic failure" ] ]
Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.	[ [ "ciprofloxacin", "Renal toxicities" ] ]
The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.	[ [ "interferon alfa", "anterior ischemic optic neuropathy" ], [ "interferon", "vascular retinopathy" ] ]
DISCUSSION: Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to cause TEN.	[ [ "Phenolphthalein", "TEN" ] ]
Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.	[ [ "Hydroxyurea", "multiple squamous cell carcinomas" ], [ "Hydroxyurea", "diffuse longitudinal melanonychia" ] ]
Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.	[ [ "dapsone", "hypersensitivity syndrome" ] ]
Visceral herpesvirus infections in leukemic patients receiving cytarabine.	[ [ "cytarabine", "Visceral herpesvirus infections" ] ]
She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.	[ [ "MTX", "Epstein-Barr virus-associated polymorphic lymphoproliferative disorder" ], [ "MTX", "immunodeficiency" ], [ "MTX", "LPD" ] ]
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.	[ [ "Valproate", "Valproate embryopathy" ] ]
Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.	[ [ "D-penicillamine", "Optic neuropathy" ] ]
Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.	[ [ "disopyramide", "fasting hypoglycemia" ] ]
CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.	[ [ "imatinib", "KS" ] ]
This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.	[ [ "nimesulide", "adverse effect of fetal renal circulation" ] ]
We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.	[ [ "bupivacaine", "bilateral vocal cord paralysis" ] ]
A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).	[ [ "procainamide", "granulocytopenia" ] ]
Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.	[ [ "enoxaparin", "generalized maculopapular rash" ] ]
Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.	[ [ "sirolimus", "Interstitial pneumonitis" ] ]
This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.	[ [ "minocycline", "severe illness" ], [ "minocycline", "massive cytokine release" ], [ "minocycline", "lymphocyte over-activation" ] ]
A woman developed delusional parasitosis when taking phenelzine.	[ [ "phenelzine", "delusional parasitosis" ] ]
SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.	[ [ "interferon", "nephrosis" ] ]
That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).	[ [ "anti-D IGIV", "hemoglobinemia" ], [ "anti-D IGIV", "disseminated intravascular coagulation" ], [ "anti-D IGIV", "DIC" ] ]
CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.	[ [ "cisplatin", "anaphylactoid reactions" ] ]
Sodium phenylbutyrate was added to treatment with HU in two patients, but failed to produce an increase in total Hb despite increasing Hb F levels.	[ [ "Sodium phenylbutyrate", "increasing Hb F" ], [ "HU", "increasing Hb F" ] ]
We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).	[ [ "TMP", "meningitis" ], [ "trimethoprim", "meningitis" ], [ "SMX", "meningitis" ], [ "sulfamethoxazole", "meningitis" ] ]
We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.	[ [ "quetiapine", "DKA" ], [ "quetiapine", "DM" ] ]
We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.	[ [ "oxaliplatin", "hemolytic-uremic syndrome" ], [ "leucovorin", "hemolytic-uremic syndrome" ], [ "5-fluorouracil", "hemolytic-uremic syndrome" ] ]
We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.	[ [ "prednisolone", "Kaposi's sarcoma" ] ]
Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.	[ [ "tigecycline", "acute pancreatitis" ] ]
Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.	[ [ "5-fluorouracil", "neurotoxicity" ] ]
We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.	[ [ "bicalutamide", "interstitial pneumonitis" ], [ "leuprorelin acetate", "interstitial pneumonitis" ] ]
The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.	[ [ "venlafaxine", "UI" ], [ "venlafaxine", "urinary incontinence" ] ]
We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.	[ [ "AZ", "acute hemorrhagic gastritis" ], [ "AZ", "AZ intoxication" ] ]
We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.	[ [ "oxaliplatin", "dermnatitis" ] ]
Clozapine induced polyserositis.	[ [ "Clozapine", "polyserositis" ] ]
Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.	[ [ "triamcinolone", "Severe loss of vision" ], [ "triamcinolone", "cataract" ] ]
Nabumetone-associated interstitial nephritis.	[ [ "Nabumetone", "interstitial nephritis" ] ]
CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.	[ [ "calcitonin", "anaphylaxis" ] ]
An adverse reaction to IFN was strongly suspected as the cause of CHF.	[ [ "IFN", "CHF" ] ]
We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.	[ [ "aminophylline", "delayed hypersensitivity reaction" ], [ "ethylenediamine", "delayed hypersensitivity reaction" ] ]
METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.	[ [ "quetiapine", "diabetic ketoacidosis" ], [ "risperidone", "diabetic ketoacidosis" ] ]
Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.	[ [ "meglumine antimoniate", "pancreatitis" ] ]
Anhedonic ejaculation with desipramine.	[ [ "desipramine", "Anhedonic ejaculation" ] ]
These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.	[ [ "prednisone", "died" ] ]
Acute drug induced hepatitis due to erlotinib.	[ [ "erlotinib", "hepatitis" ] ]
OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.	[ [ "alfa-interferon", "immune-mediated diabetes mellitus" ] ]
CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.	[ [ "warfarin", "acute dissecting thoracic aortic aneurysm" ] ]

This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.

[ [ "risperidone", "hypothermia" ] ]

The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.

[ [ "PGE1", "gastric mucosa foveolar hyperplasia" ] ]

We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.

[ [ "cyclophosphamide", "hepatic angiosarcoma" ] ]

We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.

[ [ "cytarabine", "bullous eruption" ], [ "cytarabine", "PPE" ] ]

We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.

[ [ "calcium polystyrene sulfonate", "colonic ulcer" ], [ "calcium polystyrene sulfonate", "sigmoidovesical fistula" ], [ "sorbitol", "sigmoidovesical fistula" ], [ "sorbitol", "colonic ulcer" ] ]

These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.

[ [ "M-CSF", "macrophage-related glomerular injury" ] ]

It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.

[ [ "sulfasalazine", "serositis" ], [ "sulfasalazine", "pulmonary parenchymal involvement" ], [ "sulfasalazine", "lupus" ] ]

Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).

[ [ "azathioprine", "Prenatal cytomegalovirus (CMV) infection" ], [ "azathioprine", "brain damage" ], [ "prednisolone", "Prenatal cytomegalovirus (CMV) infection" ], [ "prednisolone", "brain damage" ] ]

Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.

[ [ "amphotericin B", "cardiac arrhythmia" ] ]

A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.

[ [ "dapsone", "agranulocytosis" ] ]

This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.

[ [ "methotrexate", "acute myelocytic leukemia" ], [ "cyclophosphamide", "acute myelocytic leukemia" ], [ "5-fluorouracil", "acute myelocytic leukemia" ] ]

A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.

[ [ "pioglitazone", "bilateral lower leg edema" ] ]

A case of pyridoxine-dependent seizures is reported.

[ [ "pyridoxine", "seizures" ] ]

Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.

[ [ "DCF", "superinfection" ], [ "DCF", "immunosuppression" ] ]

After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.

[ [ "cyclosporine A", "loss of glomerular filtration rate" ], [ "cyclosporine A", "effective renal plasma flow" ] ]

We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.

[ [ "venlafaxine", "acute myocardial ischaemia" ] ]

Severe bleomycin lung toxicity: reversal with high dose corticosteroids.

[ [ "bleomycin", "lung toxicity" ] ]

During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.

[ [ "ethambutol", "visual loss" ] ]

Pulmonary gold toxicity.

[ [ "gold", "Pulmonary gold toxicity" ] ]

A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.

[ [ "colchicine", "leg weakness" ], [ "colchicine", "fatigue" ], [ "colchicine", "myalgia" ] ]

Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.

[ [ "erlotinib", "Fatal interstitial lung disease" ] ]

Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.

[ [ "octreotide", "intrahepatic bile stasis" ] ]

Thus, the patient's clinical course and workup strongly support a diagnosis of lenalidomide-induced hypersensitivity pneumonitis-like syndrome.

[ [ "lenalidomide", "hypersensitivity pneumonitis-like syndrome" ] ]

A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).

[ [ "methotrexate", "severe skin rash" ], [ "methotrexate", "bone marrow aplasia" ], [ "MTX", "severe skin rash" ], [ "MTX", "bone marrow aplasia" ] ]

A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.

[ [ "deanol", "tardive dyskinesia" ] ]

Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.

[ [ "methotrexate", "hypoxia" ], [ "methotrexate", "Pneumocystis pneumonia" ], [ "methotrexate", "fever" ], [ "methotrexate", "pulmonary infiltrates" ] ]

Mycophenolate mofetil-induced neutropenia in liver transplantation.

[ [ "Mycophenolate mofetil", "neutropenia" ] ]

Acute renal failure in a child associated with acyclovir.

[ [ "acyclovir", "Acute renal failure" ] ]

Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.

[ [ "amifostine", "anaphylactoid reaction" ] ]

We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.

[ [ "CBZ", "facial motor tics" ] ]

In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.

[ [ "piroxicam", "ulcers" ] ]

Apparent central nervous system depression in infants after the use of topical brimonidine.

[ [ "brimonidine", "central nervous system depression" ] ]

The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.

[ [ "clozapine", "hypersensitivity myocarditis" ] ]

Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.

[ [ "ritodrine", "Mobitz type I" ], [ "ritodrine", "Wenckebach AV block" ], [ "ritodrine", "Type I second-degree AV block" ] ]

Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.

[ [ "quinine", "amblyopia" ], [ "quinine", "Abnormalities of the pupil" ] ]

After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.

[ [ "argatroban", "bleeding" ] ]

However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.

[ [ "diphenhydramine", "cardiac toxicity" ] ]

BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.

[ [ "sirolimus", "Aphthous stomatitis" ] ]

We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.

[ [ "cyclosporin", "eye movement abnormality" ], [ "cyclosporin", "transient brain stem or neuromuscular dysfunction" ], [ "ganciclovir", "eye movement abnormality" ], [ "ganciclovir", "transient brain stem or neuromuscular dysfunction" ] ]

We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.

[ [ "5-FU", "severe mucositis" ], [ "5-FU", "prolonged myelosuppression" ], [ "5-FU", "neurologic toxicity" ] ]

Eruptive epidermoid cysts resulting from treatment with imiquimod.

[ [ "imiquimod", "Eruptive epidermoid cysts" ] ]

A retrospective study was conducted of 40 loperamide poisoning cases recorded at the Centre National d'Informations Toxicologiques Veterinaires.

[ [ "loperamide", "loperamide poisoning" ] ]

Asterixis induced by carbamazepine therapy.

[ [ "carbamazepine", "Asterixis" ] ]

One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.

[ [ "propranolol", "lower average mean blood pressure" ], [ "propranolol", "lower average heart rate" ] ]

We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.

[ [ "PCC", "MI" ] ]

Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.

[ [ "ribavirin", "diabetes mellitus" ], [ "interferon-alfa", "diabetes mellitus" ] ]

This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.

[ [ "mianserin", "panic anxiety" ] ]

Delusional parasitosis associated with phenelzine.

[ [ "phenelzine", "Delusional parasitosis" ] ]

Colchicine-induced myopathy in a teenager with familial Mediterranean fever.

[ [ "Colchicine", "myopathy" ] ]

We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.

[ [ "leflunomide", "hemoptysis" ], [ "leflunomide", "short-of-breath" ], [ "leflunomide", "severe weakness" ] ]

Phenylpropanolamine-induced psychosis.

[ [ "Phenylpropanolamine", "psychosis" ] ]

This confirmed the history of captopril-related asthma.

[ [ "captopril", "asthma" ] ]

Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).

[ [ "amiodarone", "thyrotropin-binding inhibiting immunoglobulin" ], [ "amiodarone", "thyrotoxicosis" ], [ "amiodarone", "transiently positive thyrotropin (TSH) receptor antibody" ] ]

To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.

[ [ "griseofulvin", "lupus" ], [ "griseofulvin", "nephrotic syndrome" ] ]

Disulfiram-induced fulminant hepatic failure in an active duty soldier.

[ [ "Disulfiram", "fulminant hepatic failure" ] ]

Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.

[ [ "ciprofloxacin", "Renal toxicities" ] ]

The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.

[ [ "interferon alfa", "anterior ischemic optic neuropathy" ], [ "interferon", "vascular retinopathy" ] ]

DISCUSSION: Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to cause TEN.

[ [ "Phenolphthalein", "TEN" ] ]

Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.

[ [ "Hydroxyurea", "multiple squamous cell carcinomas" ], [ "Hydroxyurea", "diffuse longitudinal melanonychia" ] ]

Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.

[ [ "dapsone", "hypersensitivity syndrome" ] ]

Visceral herpesvirus infections in leukemic patients receiving cytarabine.

[ [ "cytarabine", "Visceral herpesvirus infections" ] ]

She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.

[ [ "MTX", "Epstein-Barr virus-associated polymorphic lymphoproliferative disorder" ], [ "MTX", "immunodeficiency" ], [ "MTX", "LPD" ] ]

Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.

[ [ "Valproate", "Valproate embryopathy" ] ]

Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.

[ [ "D-penicillamine", "Optic neuropathy" ] ]

Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.

[ [ "disopyramide", "fasting hypoglycemia" ] ]

CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.

[ [ "imatinib", "KS" ] ]

This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

[ [ "nimesulide", "adverse effect of fetal renal circulation" ] ]

We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.

[ [ "bupivacaine", "bilateral vocal cord paralysis" ] ]

A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).

[ [ "procainamide", "granulocytopenia" ] ]

Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.

[ [ "enoxaparin", "generalized maculopapular rash" ] ]

Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.

[ [ "sirolimus", "Interstitial pneumonitis" ] ]

This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.

[ [ "minocycline", "severe illness" ], [ "minocycline", "massive cytokine release" ], [ "minocycline", "lymphocyte over-activation" ] ]

A woman developed delusional parasitosis when taking phenelzine.

[ [ "phenelzine", "delusional parasitosis" ] ]

SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.

[ [ "interferon", "nephrosis" ] ]

That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).

[ [ "anti-D IGIV", "hemoglobinemia" ], [ "anti-D IGIV", "disseminated intravascular coagulation" ], [ "anti-D IGIV", "DIC" ] ]

CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.

[ [ "cisplatin", "anaphylactoid reactions" ] ]

Sodium phenylbutyrate was added to treatment with HU in two patients, but failed to produce an increase in total Hb despite increasing Hb F levels.

[ [ "Sodium phenylbutyrate", "increasing Hb F" ], [ "HU", "increasing Hb F" ] ]

We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).

[ [ "TMP", "meningitis" ], [ "trimethoprim", "meningitis" ], [ "SMX", "meningitis" ], [ "sulfamethoxazole", "meningitis" ] ]

We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.

[ [ "quetiapine", "DKA" ], [ "quetiapine", "DM" ] ]

We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.

[ [ "oxaliplatin", "hemolytic-uremic syndrome" ], [ "leucovorin", "hemolytic-uremic syndrome" ], [ "5-fluorouracil", "hemolytic-uremic syndrome" ] ]

We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.

[ [ "prednisolone", "Kaposi's sarcoma" ] ]

Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.

[ [ "tigecycline", "acute pancreatitis" ] ]

Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.

[ [ "5-fluorouracil", "neurotoxicity" ] ]

We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.

[ [ "bicalutamide", "interstitial pneumonitis" ], [ "leuprorelin acetate", "interstitial pneumonitis" ] ]

The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.

[ [ "venlafaxine", "UI" ], [ "venlafaxine", "urinary incontinence" ] ]

We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.

[ [ "AZ", "acute hemorrhagic gastritis" ], [ "AZ", "AZ intoxication" ] ]

We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.

[ [ "oxaliplatin", "dermnatitis" ] ]

Clozapine induced polyserositis.

[ [ "Clozapine", "polyserositis" ] ]

Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.

[ [ "triamcinolone", "Severe loss of vision" ], [ "triamcinolone", "cataract" ] ]

Nabumetone-associated interstitial nephritis.

[ [ "Nabumetone", "interstitial nephritis" ] ]

CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.

[ [ "calcitonin", "anaphylaxis" ] ]

An adverse reaction to IFN was strongly suspected as the cause of CHF.

[ [ "IFN", "CHF" ] ]

We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.

[ [ "aminophylline", "delayed hypersensitivity reaction" ], [ "ethylenediamine", "delayed hypersensitivity reaction" ] ]

METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.

[ [ "quetiapine", "diabetic ketoacidosis" ], [ "risperidone", "diabetic ketoacidosis" ] ]

Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.

[ [ "meglumine antimoniate", "pancreatitis" ] ]

Anhedonic ejaculation with desipramine.

[ [ "desipramine", "Anhedonic ejaculation" ] ]

These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.

[ [ "prednisone", "died" ] ]

Acute drug induced hepatitis due to erlotinib.

[ [ "erlotinib", "hepatitis" ] ]

OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.

[ [ "alfa-interferon", "immune-mediated diabetes mellitus" ] ]

CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.

[ [ "warfarin", "acute dissecting thoracic aortic aneurysm" ] ]