harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.	[ [ "D-Pen", "bicytopenia" ] ]
A 53-year-old man developed NMS without rigidity while taking olanzapine.	[ [ "olanzapine", "NMS" ] ]
Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.	[ [ "Tamoxifen", "carcinogenic" ] ]
To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.	[ [ "amifostine", "fever" ] ]
After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.	[ [ "carbamazepine", "aggressive behavior" ], [ "carbamazepine", "severe agitation" ] ]
After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.	[ [ "ifosfamide", "unresponsive" ], [ "mesna", "unresponsive" ] ]
We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.	[ [ "bleomycin", "cutaneous scleroderma" ] ]
Hyponatraemia during low-dose carbamazepine therapy.	[ [ "carbamazepine", "Hyponatraemia" ] ]
Gemcitabine-related radiation recall in a patient with pancreatic cancer.	[ [ "Gemcitabine", "radiation recall" ] ]
Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.	[ [ "Metipranolol", "granulomatous anterior uveitis" ] ]
PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.	[ [ "tissue plasminogen activator", "spontaneous choroidal hemorrhage" ] ]
Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.	[ [ "cyanamide", "general fatigue" ] ]
A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.	[ [ "methotrexate", "acute renal failure" ] ]
Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.	[ [ "D-penicillamine", "mammary hyperplasias" ], [ "Neothetazone", "mammary hyperplasias" ] ]
We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.	[ [ "interferon alpha", "sarcoidosis" ], [ "ribavirin", "sarcoidosis" ] ]
Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.	[ [ "Heparin", "thrombocytopenia" ] ]
Amphotericin B overdose in pediatric patients with associated cardiac arrest.	[ [ "Amphotericin B", "cardiac arrest" ] ]
We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.	[ [ "high-lipase pancreatin", "submucosal fibrosis of the transverse colon" ], [ "high-lipase pancreatin", "stricture of the hepatic flexure region with associated narrowing" ] ]
We report the first case of tuberculous uveitis due to etanercept.	[ [ "etanercept", "tuberculous uveitis" ] ]
A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.	[ [ "pyrilamine maleate", "toxic encephalopathy" ], [ "pyrilamine maleate", "depressed level of consciousness" ], [ "pyrilamine maleate", "ataxia" ], [ "pyrilamine maleate", "marked irritability" ], [ "pentobarbital", "toxic encephalopathy" ], [ "pentobarbital", "ataxia" ], [ "pentobarbital", "depressed level of consciousness" ], [ "pentobarbital", "marked irritability" ] ]
The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.	[ [ "interferon-alpha", "akathisia" ], [ "interferon-alpha", "neurotoxicity" ] ]
Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.	[ [ "Trimethoprim-sulfamethoxazole", "hepatotoxicity" ] ]
A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.	[ [ "nadolol", "attacks of asthma" ], [ "dyazide", "attacks of asthma" ], [ "captopril", "attacks of asthma" ] ]
Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.	[ [ "lithium", "focal seizure" ], [ "lithium", "prolonged seizure" ], [ "lithium", "serotonin syndrome" ] ]
A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.	[ [ "prednisone", "pruritic bullous eruption" ] ]
Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.	[ [ "theophylline", "theophylline levels had increased to the toxic range" ], [ "Accolate", "theophylline levels had increased to the toxic range" ], [ "zafirlukast", "theophylline levels had increased to the toxic range" ] ]
One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.	[ [ "heparin", "priapism" ] ]
This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.	[ [ "diethylstilbestrol", "hepatocellular carcinoma" ], [ "DES", "hepatocellular carcinoma" ] ]
CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.	[ [ "cyanamide", "ground-glass hepatocytes" ], [ "cyanamide", "septum-like liver fibrosis" ] ]
Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome.	[ [ "risperidone", "Neuroleptic malignant syndrome" ] ]
Tamoxifen retinopathy.	[ [ "Tamoxifen", "retinopathy" ] ]
We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.	[ [ "lidocaine", "dilated pupils" ] ]
On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.	[ [ "danazol", "gingival bleeding" ], [ "danazol", "purpura" ] ]
Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.	[ [ "sunitinib", "gynaecomastia" ] ]
Spinal cord infarction during use of zolmitriptan: a case report.	[ [ "zolmitriptan", "Spinal cord infarction" ] ]
Careful follow-up of so-called "self-limited" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.	[ [ "insulin", "edema" ] ]
Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.	[ [ "valproic acid", "lethargy" ], [ "valproic acid", "Hyperammonemia" ] ]
This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.	[ [ "ddI", "fulminant hepatitis" ] ]
We report here a rare case of pleuropericarditis due to methotrexate.	[ [ "methotrexate", "pleuropericarditis" ] ]
Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.	[ [ "bimatoprost", "Cystoid macular edema" ], [ "latanoprost", "Cystoid macular edema" ] ]
Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.	[ [ "interferon-alpha", "akathisia" ] ]
We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.	[ [ "ara = C", "leukoencephalopathy" ], [ "methotrexate", "leukoencephalopathy" ] ]
Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.	[ [ "amphotericin B", "cardiac arrhythmias" ], [ "amphotericin B", "mortality" ] ]
A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.	[ [ "leflunomide", "syringotropic hypersensitivity reaction" ], [ "infliximab", "syringotropic hypersensitivity reaction" ] ]
Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.	[ [ "Heparin", "thrombosis" ], [ "heparin", "thrombocytopenia" ], [ "Heparin", "thrombocytopenia" ], [ "heparin", "thrombosis" ] ]
Ulcer became worse after tobramycin and gentamycin treatment for 2 days.	[ [ "tobramycin", "Ulcer became worse" ], [ "gentamycin", "Ulcer became worse" ] ]
RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.	[ [ "Brimonidine", "IOP elevation" ] ]
Cytarabine-induced cerebellar syndrome: case report and literature review.	[ [ "Cytarabine", "cerebellar syndrome" ] ]
A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.	[ [ "SMX", "cervical lymphadenopathy" ], [ "sulfamethoxazole", "cervical lymphadenopathy" ], [ "SMX", "hepatosplenomegaly" ], [ "trimethoprim", "skin eruptions" ], [ "trimethoprim", "hepatosplenomegaly" ], [ "sulfamethoxazole", "atypical lymphocytosis" ], [ "TMP", "eosinophilia" ], [ "SMX", "eosinophilia" ], [ "trimethoprim", "cervical lymphadenopathy" ], [ "SMX", "fever" ], [ "trimethoprim", "eosinophilia" ], [ "SMX", "skin eruptions" ], [ "sulfamethoxazole", "hepatosplenomegaly" ], [ "sulfamethoxazole", "fever" ], [ "sulfamethoxazole", "eosinophilia" ], [ "SMX", "atypical lymphocytosis" ], [ "TMP", "atypical lymphocytosis" ], [ "sulfamethoxazole", "skin eruptions" ], [ "TMP", "fever" ], [ "trimethoprim", "fever" ], [ "TMP", "cervical lymphadenopathy" ], [ "TMP", "skin eruptions" ], [ "trimethoprim", "atypical lymphocytosis" ], [ "TMP", "hepatosplenomegaly" ] ]
The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.	[ [ "bupropion", "seizures" ], [ "bupropion", "vomiting" ], [ "bupropion", "agitation" ], [ "bupropion", "tachycardia" ], [ "bupropion", "hallucinations" ] ]
She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.	[ [ "acyclovir", "VZV antigen-positive zoster" ] ]
Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.	[ [ "Cyclosporine", "rhabdomyolysis" ], [ "simvastatin", "rhabdomyolysis" ] ]
We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.	[ [ "cladribine", "systemic vasculitis" ], [ "cladribine", "thrombocytopenia" ] ]
Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.	[ [ "cyclosporine A", "nephrotoxicity" ] ]
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.	[ [ "valproic acid", "raised intracranial pressure" ] ]
Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.	[ [ "etoposide", "Paroxysmal supraventricular tachycardia" ], [ "cisplatin", "Paroxysmal supraventricular tachycardia" ] ]
CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.	[ [ "Amantadine", "reversible corneal edema" ] ]
The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.	[ [ "chloroacetaldehyde", "toxicity" ], [ "ifosfamide", "toxicity" ], [ "4-hydroxyifosfamide", "toxicity" ] ]
Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.	[ [ "miconazole", "cardiorespiratory and anaphylactic reactions" ] ]
She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.	[ [ "phenytoin sodium", "leukopenia" ], [ "carbamazepine", "leukopenia" ] ]
Quetiapine-induced myoclonus.	[ [ "Quetiapine", "myoclonus" ] ]
We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.	[ [ "carbamazepine", "psoriasiform eruption" ], [ "sodium valproate", "psoriasiform eruption" ] ]
METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.	[ [ "quetiapine", "haematological adverse effects" ] ]
Histopathology of the thyroid in amiodarone-induced hypothyroidism.	[ [ "amiodarone", "hypothyroidism" ] ]
Additive pulmonary toxicity with melphalan and busulfan therapy.	[ [ "melphalan", "Additive pulmonary toxicity" ], [ "busulfan", "Additive pulmonary toxicity" ] ]
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.	[ [ "L-asparaginase", "Intracranial hemorrhage" ], [ "L-asparaginase", "focal seizures" ] ]
We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.	[ [ "interferon alfa", "cutaneous necrosis" ], [ "pegylated interferon alfa-2b", "cutaneous necrosis" ] ]
We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.	[ [ "valproic acid", "lethargy" ], [ "valproic acid", "hyperammonemia" ] ]
Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.	[ [ "25-hydroxyvitain D3", "ileal resection" ] ]
It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.	[ [ "valacyclovir", "neurotoxicity" ] ]
We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.	[ [ "clozapine", "EPS" ] ]
Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.	[ [ "Isotretinoin", "teratogenic effects" ] ]
The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.	[ [ "infliximab", "nodular sclerosing Hodgkin's lymphoma" ] ]
An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.	[ [ "venlafaxine", "acute ischaemic event" ] ]
Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.	[ [ "Isonicotinic acid hydrazide", "lichenoid eruption" ], [ "Isonicotinic acid hydrazide", "anagen effluvium" ] ]
Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.	[ [ "Rituximab-CHOP", "interstitial pneumonitis" ] ]
Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.	[ [ "vincristine", "severe visual loss" ] ]
Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).	[ [ "L-dopa", "Myoclonus" ], [ "L-dopa", "seizures" ] ]
Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.	[ [ "Nitrofurantoin", "lung disease" ] ]
Self-limited edema is a well-recognized complication of insulin therapy.	[ [ "insulin", "Self-limited edema" ] ]
An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.	[ [ "aluminum", "encephalopathy" ], [ "aluminum", "cardiomyopathy" ] ]
A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.	[ [ "amoxapine", "galactorrhea" ], [ "dibenzoxazepine", "galactorrhea" ] ]
Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.	[ [ "Ibuprofen", "meningitis" ] ]
In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.	[ [ "hepatitis B vaccination", "acute onset tetraparesia" ] ]
OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.	[ [ "rofecoxib", "lower gastrointestinal symptoms" ] ]
CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.	[ [ "gefitinib", "Acute severe hepatitis" ], [ "erlotinib", "Acute severe hepatitis" ] ]
Cardiac toxicity related to BCNU has not been described well.	[ [ "BCNU", "Cardiac toxicity" ] ]
Serious adverse events experienced by patients with chronic heart failure taking spironolactone.	[ [ "spironolactone", "Serious adverse events" ] ]
Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.	[ [ "sucralfate", "hypophosphatemic osteomalacia" ] ]
We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.	[ [ "carmustine", "fatal case of acute interstitial pneumonitis" ], [ "BCNU", "fatal case of acute interstitial pneumonitis" ] ]
Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.	[ [ "clozapine", "agranulocytosis" ] ]
Gold-induced pneumonitis is a rare complication of gold salt therapy.	[ [ "Gold", "pneumonitis" ] ]
Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.	[ [ "methotrexate", "Interstitial fibrosis of the lung" ] ]
Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.	[ [ "propylthiouracil", "acute hepatic failure" ] ]
We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.	[ [ "low-molecular weight heparin", "skin necrosis" ] ]
Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.	[ [ "indomethacin", "premature closure of the ductus arteriosus" ] ]
Septic knee arthritis after intra-articular hyaluronate injection.	[ [ "hyaluronate", "Septic knee arthritis" ] ]
Paradoxical seizures in phenytoin toxicity.	[ [ "phenytoin", "seizures" ] ]
Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.	[ [ "bicalutamide", "interstitial pneumonitis" ], [ "leuprorelin acetate", "interstitial pneumonitis" ] ]
Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.	[ [ "infliximab", "Mycobacterium marinum infection" ] ]

Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.

[ [ "D-Pen", "bicytopenia" ] ]

A 53-year-old man developed NMS without rigidity while taking olanzapine.

[ [ "olanzapine", "NMS" ] ]

Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.

[ [ "Tamoxifen", "carcinogenic" ] ]

To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.

[ [ "amifostine", "fever" ] ]

After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.

[ [ "carbamazepine", "aggressive behavior" ], [ "carbamazepine", "severe agitation" ] ]

After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.

[ [ "ifosfamide", "unresponsive" ], [ "mesna", "unresponsive" ] ]

We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.

[ [ "bleomycin", "cutaneous scleroderma" ] ]

Hyponatraemia during low-dose carbamazepine therapy.

[ [ "carbamazepine", "Hyponatraemia" ] ]

Gemcitabine-related radiation recall in a patient with pancreatic cancer.

[ [ "Gemcitabine", "radiation recall" ] ]

Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.

[ [ "Metipranolol", "granulomatous anterior uveitis" ] ]

PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.

[ [ "tissue plasminogen activator", "spontaneous choroidal hemorrhage" ] ]

Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.

[ [ "cyanamide", "general fatigue" ] ]

A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.

[ [ "methotrexate", "acute renal failure" ] ]

Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.

[ [ "D-penicillamine", "mammary hyperplasias" ], [ "Neothetazone", "mammary hyperplasias" ] ]

We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.

[ [ "interferon alpha", "sarcoidosis" ], [ "ribavirin", "sarcoidosis" ] ]

Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.

[ [ "Heparin", "thrombocytopenia" ] ]

Amphotericin B overdose in pediatric patients with associated cardiac arrest.

[ [ "Amphotericin B", "cardiac arrest" ] ]

We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.

[ [ "high-lipase pancreatin", "submucosal fibrosis of the transverse colon" ], [ "high-lipase pancreatin", "stricture of the hepatic flexure region with associated narrowing" ] ]

We report the first case of tuberculous uveitis due to etanercept.

[ [ "etanercept", "tuberculous uveitis" ] ]

A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.

[ [ "pyrilamine maleate", "toxic encephalopathy" ], [ "pyrilamine maleate", "depressed level of consciousness" ], [ "pyrilamine maleate", "ataxia" ], [ "pyrilamine maleate", "marked irritability" ], [ "pentobarbital", "toxic encephalopathy" ], [ "pentobarbital", "ataxia" ], [ "pentobarbital", "depressed level of consciousness" ], [ "pentobarbital", "marked irritability" ] ]

The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.

[ [ "interferon-alpha", "akathisia" ], [ "interferon-alpha", "neurotoxicity" ] ]

Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.

[ [ "Trimethoprim-sulfamethoxazole", "hepatotoxicity" ] ]

A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.

[ [ "nadolol", "attacks of asthma" ], [ "dyazide", "attacks of asthma" ], [ "captopril", "attacks of asthma" ] ]

Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.

[ [ "lithium", "focal seizure" ], [ "lithium", "prolonged seizure" ], [ "lithium", "serotonin syndrome" ] ]

A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.

[ [ "prednisone", "pruritic bullous eruption" ] ]

Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.

[ [ "theophylline", "theophylline levels had increased to the toxic range" ], [ "Accolate", "theophylline levels had increased to the toxic range" ], [ "zafirlukast", "theophylline levels had increased to the toxic range" ] ]

One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.

[ [ "heparin", "priapism" ] ]

This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.

[ [ "diethylstilbestrol", "hepatocellular carcinoma" ], [ "DES", "hepatocellular carcinoma" ] ]

CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.

[ [ "cyanamide", "ground-glass hepatocytes" ], [ "cyanamide", "septum-like liver fibrosis" ] ]

Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome.

[ [ "risperidone", "Neuroleptic malignant syndrome" ] ]

Tamoxifen retinopathy.

[ [ "Tamoxifen", "retinopathy" ] ]

We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.

[ [ "lidocaine", "dilated pupils" ] ]

On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.

[ [ "danazol", "gingival bleeding" ], [ "danazol", "purpura" ] ]

Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.

[ [ "sunitinib", "gynaecomastia" ] ]

Spinal cord infarction during use of zolmitriptan: a case report.

[ [ "zolmitriptan", "Spinal cord infarction" ] ]

Careful follow-up of so-called "self-limited" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.

[ [ "insulin", "edema" ] ]

Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.

[ [ "valproic acid", "lethargy" ], [ "valproic acid", "Hyperammonemia" ] ]

This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.

[ [ "ddI", "fulminant hepatitis" ] ]

We report here a rare case of pleuropericarditis due to methotrexate.

[ [ "methotrexate", "pleuropericarditis" ] ]

Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.

[ [ "bimatoprost", "Cystoid macular edema" ], [ "latanoprost", "Cystoid macular edema" ] ]

Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.

[ [ "interferon-alpha", "akathisia" ] ]

We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.

[ [ "ara = C", "leukoencephalopathy" ], [ "methotrexate", "leukoencephalopathy" ] ]

Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.

[ [ "amphotericin B", "cardiac arrhythmias" ], [ "amphotericin B", "mortality" ] ]

A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.

[ [ "leflunomide", "syringotropic hypersensitivity reaction" ], [ "infliximab", "syringotropic hypersensitivity reaction" ] ]

Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.

[ [ "Heparin", "thrombosis" ], [ "heparin", "thrombocytopenia" ], [ "Heparin", "thrombocytopenia" ], [ "heparin", "thrombosis" ] ]

Ulcer became worse after tobramycin and gentamycin treatment for 2 days.

[ [ "tobramycin", "Ulcer became worse" ], [ "gentamycin", "Ulcer became worse" ] ]

RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.

[ [ "Brimonidine", "IOP elevation" ] ]

Cytarabine-induced cerebellar syndrome: case report and literature review.

[ [ "Cytarabine", "cerebellar syndrome" ] ]

A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.

[ [ "SMX", "cervical lymphadenopathy" ], [ "sulfamethoxazole", "cervical lymphadenopathy" ], [ "SMX", "hepatosplenomegaly" ], [ "trimethoprim", "skin eruptions" ], [ "trimethoprim", "hepatosplenomegaly" ], [ "sulfamethoxazole", "atypical lymphocytosis" ], [ "TMP", "eosinophilia" ], [ "SMX", "eosinophilia" ], [ "trimethoprim", "cervical lymphadenopathy" ], [ "SMX", "fever" ], [ "trimethoprim", "eosinophilia" ], [ "SMX", "skin eruptions" ], [ "sulfamethoxazole", "hepatosplenomegaly" ], [ "sulfamethoxazole", "fever" ], [ "sulfamethoxazole", "eosinophilia" ], [ "SMX", "atypical lymphocytosis" ], [ "TMP", "atypical lymphocytosis" ], [ "sulfamethoxazole", "skin eruptions" ], [ "TMP", "fever" ], [ "trimethoprim", "fever" ], [ "TMP", "cervical lymphadenopathy" ], [ "TMP", "skin eruptions" ], [ "trimethoprim", "atypical lymphocytosis" ], [ "TMP", "hepatosplenomegaly" ] ]

The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.

[ [ "bupropion", "seizures" ], [ "bupropion", "vomiting" ], [ "bupropion", "agitation" ], [ "bupropion", "tachycardia" ], [ "bupropion", "hallucinations" ] ]

She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.

[ [ "acyclovir", "VZV antigen-positive zoster" ] ]

Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.

[ [ "Cyclosporine", "rhabdomyolysis" ], [ "simvastatin", "rhabdomyolysis" ] ]

We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.

[ [ "cladribine", "systemic vasculitis" ], [ "cladribine", "thrombocytopenia" ] ]

Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.

[ [ "cyclosporine A", "nephrotoxicity" ] ]

Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.

[ [ "valproic acid", "raised intracranial pressure" ] ]

Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.

[ [ "etoposide", "Paroxysmal supraventricular tachycardia" ], [ "cisplatin", "Paroxysmal supraventricular tachycardia" ] ]

CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.

[ [ "Amantadine", "reversible corneal edema" ] ]

The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.

[ [ "chloroacetaldehyde", "toxicity" ], [ "ifosfamide", "toxicity" ], [ "4-hydroxyifosfamide", "toxicity" ] ]

Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.

[ [ "miconazole", "cardiorespiratory and anaphylactic reactions" ] ]

She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.

[ [ "phenytoin sodium", "leukopenia" ], [ "carbamazepine", "leukopenia" ] ]

Quetiapine-induced myoclonus.

[ [ "Quetiapine", "myoclonus" ] ]

We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.

[ [ "carbamazepine", "psoriasiform eruption" ], [ "sodium valproate", "psoriasiform eruption" ] ]

METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.

[ [ "quetiapine", "haematological adverse effects" ] ]

Histopathology of the thyroid in amiodarone-induced hypothyroidism.

[ [ "amiodarone", "hypothyroidism" ] ]

Additive pulmonary toxicity with melphalan and busulfan therapy.

[ [ "melphalan", "Additive pulmonary toxicity" ], [ "busulfan", "Additive pulmonary toxicity" ] ]

Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.

[ [ "L-asparaginase", "Intracranial hemorrhage" ], [ "L-asparaginase", "focal seizures" ] ]

We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.

[ [ "interferon alfa", "cutaneous necrosis" ], [ "pegylated interferon alfa-2b", "cutaneous necrosis" ] ]

We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.

[ [ "valproic acid", "lethargy" ], [ "valproic acid", "hyperammonemia" ] ]

Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.

[ [ "25-hydroxyvitain D3", "ileal resection" ] ]

It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.

[ [ "valacyclovir", "neurotoxicity" ] ]

We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.

[ [ "clozapine", "EPS" ] ]

Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.

[ [ "Isotretinoin", "teratogenic effects" ] ]

The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.

[ [ "infliximab", "nodular sclerosing Hodgkin's lymphoma" ] ]

An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.

[ [ "venlafaxine", "acute ischaemic event" ] ]

Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.

[ [ "Isonicotinic acid hydrazide", "lichenoid eruption" ], [ "Isonicotinic acid hydrazide", "anagen effluvium" ] ]

Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.

[ [ "Rituximab-CHOP", "interstitial pneumonitis" ] ]

Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.

[ [ "vincristine", "severe visual loss" ] ]

Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).

[ [ "L-dopa", "Myoclonus" ], [ "L-dopa", "seizures" ] ]

Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.

[ [ "Nitrofurantoin", "lung disease" ] ]

Self-limited edema is a well-recognized complication of insulin therapy.

[ [ "insulin", "Self-limited edema" ] ]

An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.

[ [ "aluminum", "encephalopathy" ], [ "aluminum", "cardiomyopathy" ] ]

A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.

[ [ "amoxapine", "galactorrhea" ], [ "dibenzoxazepine", "galactorrhea" ] ]

Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.

[ [ "Ibuprofen", "meningitis" ] ]

In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.

[ [ "hepatitis B vaccination", "acute onset tetraparesia" ] ]

OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.

[ [ "rofecoxib", "lower gastrointestinal symptoms" ] ]

CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.

[ [ "gefitinib", "Acute severe hepatitis" ], [ "erlotinib", "Acute severe hepatitis" ] ]

Cardiac toxicity related to BCNU has not been described well.

[ [ "BCNU", "Cardiac toxicity" ] ]

Serious adverse events experienced by patients with chronic heart failure taking spironolactone.

[ [ "spironolactone", "Serious adverse events" ] ]

Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.

[ [ "sucralfate", "hypophosphatemic osteomalacia" ] ]

We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.

[ [ "carmustine", "fatal case of acute interstitial pneumonitis" ], [ "BCNU", "fatal case of acute interstitial pneumonitis" ] ]

Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.

[ [ "clozapine", "agranulocytosis" ] ]

Gold-induced pneumonitis is a rare complication of gold salt therapy.

[ [ "Gold", "pneumonitis" ] ]

Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.

[ [ "methotrexate", "Interstitial fibrosis of the lung" ] ]

Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.

[ [ "propylthiouracil", "acute hepatic failure" ] ]

We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.

[ [ "low-molecular weight heparin", "skin necrosis" ] ]

Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.

[ [ "indomethacin", "premature closure of the ductus arteriosus" ] ]

Septic knee arthritis after intra-articular hyaluronate injection.

[ [ "hyaluronate", "Septic knee arthritis" ] ]

Paradoxical seizures in phenytoin toxicity.

[ [ "phenytoin", "seizures" ] ]

Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.

[ [ "bicalutamide", "interstitial pneumonitis" ], [ "leuprorelin acetate", "interstitial pneumonitis" ] ]

Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.

[ [ "infliximab", "Mycobacterium marinum infection" ] ]