harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.	[ [ "isoniazid", "acute renal failure" ], [ "rifampin", "acute renal failure" ] ]
The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.	[ [ "nitrofurantoin", "nitrofurantoin induced BOOP" ], [ "nitrofurantoin", "fatal outcome" ] ]
By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.	[ [ "heparin", "platelet activation" ], [ "Clexane", "platelet activation" ], [ "Fraxiparin", "platelet activation" ], [ "Fragmin", "platelet activation" ] ]
Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.	[ [ "aspirin", "Reye syndrome" ], [ "aspirin", "RS" ] ]
Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.	[ [ "ergot", "gangrene of the extremities" ], [ "ergot", "arteriospasm" ] ]
Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.	[ [ "gold sodium thiomalate", "Stroke-like syndrome" ], [ "gold sodium thiomalate", "vasomotor reaction" ] ]
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.	[ [ "amiodarone", "pleural and pericardial effusion" ], [ "amiodarone", "Pneumonitis" ], [ "amiodarone", "neuropathy" ] ]
Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?	[ [ "carboplatin", "hypersensitivity" ] ]
We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.	[ [ "oxybutynin", "focal seizure" ], [ "oxybutynin", "hypertension" ], [ "oxybutynin", "acute bilateral blindness" ] ]
We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.	[ [ "morphine", "confusion" ], [ "morphine", "chronic nausea" ] ]
METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.	[ [ "topiramate", "acute myopia" ] ]
Bull's-eye maculopathy associated with quinacrine therapy for malaria.	[ [ "quinacrine", "Bull's-eye maculopathy" ] ]
Liver transplantation for fulminant hepatitis related to nevirapine therapy.	[ [ "nevirapine", "fulminant hepatitis" ] ]
We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).	[ [ "daunomycin", "symptomatic cardiomyopathy" ], [ "ATRA", "symptomatic cardiomyopathy" ], [ "all-trans retinoic acid", "symptomatic cardiomyopathy" ] ]
It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.	[ [ "finasteride", "anterior subcapsular opacity on the lens" ] ]
We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.	[ [ "dofetilide", "QT prolongation" ], [ "dofetilide", "flash pulmonary edema" ], [ "dofetilide", "acute myocardial ischemia" ], [ "dofetilide", "torsades de pointes" ] ]
Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.	[ [ "linezolid", "peripheral neuropathy" ], [ "linezolid", "bone marrow depression" ] ]
Leishmania infantum leishmaniasis in corticosteroid--treated patients.	[ [ "corticosteroid", "Leishmania infantum leishmaniasis" ] ]
CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.	[ [ "HCQ", "cardiac arrhythmias" ] ]
Here, we report a case of RFP-induced hypothyroidism without underlying thyroid disease.	[ [ "RFP", "hypothyroidism" ] ]
A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.	[ [ "magnesium sulfate", "PTH" ], [ "magnesium sulfate", "low plasma parathyroid hormone" ], [ "magnesium sulfate", "severe hypocalcemia" ] ]
Epoprostenol may be associated rarely with severe erythroderma.	[ [ "Epoprostenol", "erythroderma" ] ]
Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.	[ [ "bleomycin", "scleroderma" ] ]
Rhabdomyolysis associated with the use of intravenous vasopressin.	[ [ "vasopressin", "Rhabdomyolysis" ] ]
Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.	[ [ "ticlopidine", "Agranulocytosis" ] ]
Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.	[ [ "clozapine", "eosinophilia" ] ]
We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.	[ [ "temozolomide", "disseminated salmonellosis" ] ]
While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.	[ [ "prednisolone", "diabetic milieu deteriorated" ] ]
Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.	[ [ "metoclopramide", "nonthrombocytopenic palpable purpura" ] ]
Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.	[ [ "G-CSF", "Leukaemoid monocytosis" ] ]
Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.	[ [ "sodium nitroprusside", "leucopenia" ], [ "sodium nitroprusside", "thrombocytopenia" ] ]
After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.	[ [ "IL-2", "toxic epidermal necrolysis" ], [ "IL-2", "hemorrhagic lesion" ], [ "IL-2", "pancytopenia" ] ]
Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.	[ [ "acetazolamide", "Severe osteomalacia" ], [ "phenobarbital", "Severe osteomalacia" ], [ "phenytoin", "Severe osteomalacia" ] ]
A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.	[ [ "trastuzumab", "pulmonary infiltrates" ], [ "trastuzumab", "plural effusion dyspnoea" ] ]
Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.	[ [ "IFN-alpha", "Graves' hyperthyroidism" ], [ "IFN-alpha", "thyrotoxicosis" ] ]
The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).	[ [ "TCA", "Cushing's syndrome" ] ]
Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.	[ [ "methotrexate", "bilateral pulmonary infiltrates" ], [ "methotrexate", "diffuse interstitial pulmonary fibrosis" ] ]
Doxycycline-induced photo-onycholysis.	[ [ "Doxycycline", "photo-onycholysis" ] ]
Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.	[ [ "cilastatin", "neutropenic fever" ], [ "imipenem", "neutropenic fever" ] ]
PURPOSE: To report a case of nodular scleritis following alendronate sodium.	[ [ "alendronate sodium", "nodular scleritis" ] ]
When co-trimoxazole was stopped the red cell aplasia resolved.	[ [ "co-trimoxazole", "red cell aplasia" ] ]
Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared.	[ [ "PTU", "ANCA" ] ]
On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.	[ [ "dalteparin", "acute respiratory distress" ] ]
Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.	[ [ "Isoniazid", "pellagra" ] ]
However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.	[ [ "troglitazone", "liver injury" ] ]
Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.	[ [ "sulfasalazine", "positive autoantibodies" ], [ "sulfasalazine", "Pneumonitis" ], [ "sulfasalazine", "cardiac tamponade" ], [ "sulfasalazine", "bilateral pleural effusions" ] ]
Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.	[ [ "cyclophosphamide", "Subglottic stenosis" ] ]
Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.	[ [ "CDDP", "SIADH" ] ]
Venlafaxine-induced urinary incontinence resolved after switching to sertraline.	[ [ "Venlafaxine", "urinary incontinence" ] ]
Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.	[ [ "mefloquine", "hypoglycaemia" ] ]
Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.	[ [ "cisplatin", "Anaphylaxis" ] ]
DISCUSSION: After exclusion of other causes, the onset of thrombocytopenia after administration of lansoprazole, the resolution of the adverse reaction after discontinuation of the drug, and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole.	[ [ "lansoprazole", "thrombocytopenic" ], [ "lansoprazole", "thrombocytopenia" ] ]
Erosion of psoriatic plaques: an early sign of methotrexate toxicity.	[ [ "methotrexate", "Erosion of psoriatic plaques" ], [ "methotrexate", "methotrexate toxicity" ] ]
A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.	[ [ "oolong tea", "delirious" ] ]
Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.	[ [ "Para-aminosalicylic acid", "hypoglycaemia" ] ]
Protamine allergy as a complication of insulin hypersensitivity: A case report.	[ [ "insulin", "Protamine allergy" ] ]
Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.	[ [ "IFN-alpha", "autoimmune thyroiditis" ], [ "IFN-alpha", "thyroid disorders" ] ]
Voriconazole (VRC) has not previously been reported to cause angio-oedema.	[ [ "VRC", "angio-oedema" ], [ "Voriconazole", "angio-oedema" ] ]
Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.	[ [ "IFN beta", "Grade 3 hepatotoxicity" ] ]
We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.	[ [ "sibutramine", "hyponatremia" ] ]
Anisocoria from transdermal scopolamine.	[ [ "scopolamine", "Anisocoria" ] ]
Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.	[ [ "Doxorubicin", "cardiotoxicity" ] ]
Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.	[ [ "tamoxifen", "Ovarian endometrioid adenocarcinoma" ] ]
To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.	[ [ "captopril", "pemphigus" ] ]
CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.	[ [ "lansoprazole", "thrombocytopenia" ] ]
Ketanserin in the treatment of protamine-induced pulmonary hypertension.	[ [ "protamine", "pulmonary hypertension" ] ]
Tetany in a child with AIDS receiving intravenous tobramycin.	[ [ "tobramycin", "Tetany" ] ]
Scleroderma in association with the use of bleomycin: a report of 3 cases.	[ [ "bleomycin", "Scleroderma" ] ]
Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.	[ [ "lithium", "delirious" ] ]
After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.	[ [ "metamizole", "sepsis" ] ]
It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.	[ [ "methotrexate", "diffuse interstitial pulmonary fibrosis" ] ]
We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.	[ [ "phenol", "acute unilateral total visual loss" ] ]
Temozolomide was restarted 2 months later; the patient again developed a fever.	[ [ "Temozolomide", "fever" ] ]
A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.	[ [ "dapsone", "reversal reaction" ], [ "rifampin", "reversal reaction" ] ]
Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.	[ [ "calcium hopantenate", "pantothenic acid deficiency" ], [ "calcium hopantenate", "Reye-like syndrome" ] ]
We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.	[ [ "disulfiram", "fatal fulminant hepatitis" ] ]
This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.	[ [ "TMP-SMX", "hypersensitivity syndrome" ] ]
Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre".	[ [ "sweet spirits of nitre", "Sudden death" ] ]
Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.	[ [ "magnesium", "magnesium toxicosis" ], [ "magnesium sulfate", "magnesium toxicosis" ] ]
Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.	[ [ "cladribine", "Systemic vasculitis" ] ]
The patient suffered a life-threatening anaphylactoid reaction to amifostine.	[ [ "amifostine", "life-threatening anaphylactoid reaction" ] ]
The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.	[ [ "valproic acid", "FVS" ] ]
Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.	[ [ "trihexyphenidyl", "acute respiratory difficulties" ], [ "trihexyphenidyl", "cranial dystonia" ], [ "trihexyphenidyl", "inspiratory stridor" ] ]
During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.	[ [ "terlipressin", "torsade de pointes" ], [ "terlipressin", "prolonged QT interval" ] ]
Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.	[ [ "pegylated interferon alpha", "Acute dystonia" ] ]
Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.	[ [ "amphotericin B deoxycholate", "cardiac toxicity" ] ]
There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.	[ [ "ribavirin", "granulomatosis" ], [ "interferon alfa", "granulomatosis" ] ]
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.	[ [ "nimesulide", "AGEP" ], [ "nimesulide", "acute generalized exanthematous pustulosis" ] ]
Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.	[ [ "paclitaxel", "lung fibrosis" ], [ "paclitaxel", "pneumonitis" ] ]
Development of Peyronie's disease during long-term colchicine treatment.	[ [ "colchicine", "Peyronie's disease" ] ]
Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.	[ [ "levamisole", "Cerebral demyelinating disease" ] ]
Corneal endothelial dysfunction associated with amantadine toxicity.	[ [ "amantadine", "Corneal endothelial dysfunction" ] ]
Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.	[ [ "trazodone", "movement disorder" ] ]
However, we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function.	[ [ "ethambutol", "toxic optic neuropathies" ], [ "ethambutol", "visual loss" ] ]
Due to the severity of the rash, temozolomide was permanently discontinued.	[ [ "temozolomide", "rash" ] ]
Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.	[ [ "rifampin", "tubular and interstitial lesions" ] ]
OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.	[ [ "succinylcholine", "fatal hyperkalemia" ] ]
Bone formation induced in an infant by systemic prostaglandin-E2 administration.	[ [ "prostaglandin-E2", "Bone formation" ] ]
When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.	[ [ "isoniazid", "histamine reaction" ] ]
The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.	[ [ "colchicine", "corneal ulcers refractory to conventional treatment" ] ]

Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.

[ [ "isoniazid", "acute renal failure" ], [ "rifampin", "acute renal failure" ] ]

The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.

[ [ "nitrofurantoin", "nitrofurantoin induced BOOP" ], [ "nitrofurantoin", "fatal outcome" ] ]

By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.

[ [ "heparin", "platelet activation" ], [ "Clexane", "platelet activation" ], [ "Fraxiparin", "platelet activation" ], [ "Fragmin", "platelet activation" ] ]

Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.

[ [ "aspirin", "Reye syndrome" ], [ "aspirin", "RS" ] ]

Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.

[ [ "ergot", "gangrene of the extremities" ], [ "ergot", "arteriospasm" ] ]

Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.

[ [ "gold sodium thiomalate", "Stroke-like syndrome" ], [ "gold sodium thiomalate", "vasomotor reaction" ] ]

Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.

[ [ "amiodarone", "pleural and pericardial effusion" ], [ "amiodarone", "Pneumonitis" ], [ "amiodarone", "neuropathy" ] ]

Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?

[ [ "carboplatin", "hypersensitivity" ] ]

We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.

[ [ "oxybutynin", "focal seizure" ], [ "oxybutynin", "hypertension" ], [ "oxybutynin", "acute bilateral blindness" ] ]

We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.

[ [ "morphine", "confusion" ], [ "morphine", "chronic nausea" ] ]

METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.

[ [ "topiramate", "acute myopia" ] ]

Bull's-eye maculopathy associated with quinacrine therapy for malaria.

[ [ "quinacrine", "Bull's-eye maculopathy" ] ]

Liver transplantation for fulminant hepatitis related to nevirapine therapy.

[ [ "nevirapine", "fulminant hepatitis" ] ]

We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).

[ [ "daunomycin", "symptomatic cardiomyopathy" ], [ "ATRA", "symptomatic cardiomyopathy" ], [ "all-trans retinoic acid", "symptomatic cardiomyopathy" ] ]

It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.

[ [ "finasteride", "anterior subcapsular opacity on the lens" ] ]

We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.

[ [ "dofetilide", "QT prolongation" ], [ "dofetilide", "flash pulmonary edema" ], [ "dofetilide", "acute myocardial ischemia" ], [ "dofetilide", "torsades de pointes" ] ]

Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.

[ [ "linezolid", "peripheral neuropathy" ], [ "linezolid", "bone marrow depression" ] ]

Leishmania infantum leishmaniasis in corticosteroid--treated patients.

[ [ "corticosteroid", "Leishmania infantum leishmaniasis" ] ]

CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.

[ [ "HCQ", "cardiac arrhythmias" ] ]

Here, we report a case of RFP-induced hypothyroidism without underlying thyroid disease.

[ [ "RFP", "hypothyroidism" ] ]

A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.

[ [ "magnesium sulfate", "PTH" ], [ "magnesium sulfate", "low plasma parathyroid hormone" ], [ "magnesium sulfate", "severe hypocalcemia" ] ]

Epoprostenol may be associated rarely with severe erythroderma.

[ [ "Epoprostenol", "erythroderma" ] ]

Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.

[ [ "bleomycin", "scleroderma" ] ]

Rhabdomyolysis associated with the use of intravenous vasopressin.

[ [ "vasopressin", "Rhabdomyolysis" ] ]

Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.

[ [ "ticlopidine", "Agranulocytosis" ] ]

Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.

[ [ "clozapine", "eosinophilia" ] ]

We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.

[ [ "temozolomide", "disseminated salmonellosis" ] ]

While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.

[ [ "prednisolone", "diabetic milieu deteriorated" ] ]

Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

[ [ "metoclopramide", "nonthrombocytopenic palpable purpura" ] ]

Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.

[ [ "G-CSF", "Leukaemoid monocytosis" ] ]

Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.

[ [ "sodium nitroprusside", "leucopenia" ], [ "sodium nitroprusside", "thrombocytopenia" ] ]

After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.

[ [ "IL-2", "toxic epidermal necrolysis" ], [ "IL-2", "hemorrhagic lesion" ], [ "IL-2", "pancytopenia" ] ]

Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.

[ [ "acetazolamide", "Severe osteomalacia" ], [ "phenobarbital", "Severe osteomalacia" ], [ "phenytoin", "Severe osteomalacia" ] ]

A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.

[ [ "trastuzumab", "pulmonary infiltrates" ], [ "trastuzumab", "plural effusion dyspnoea" ] ]

Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.

[ [ "IFN-alpha", "Graves' hyperthyroidism" ], [ "IFN-alpha", "thyrotoxicosis" ] ]

The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).

[ [ "TCA", "Cushing's syndrome" ] ]

Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.

[ [ "methotrexate", "bilateral pulmonary infiltrates" ], [ "methotrexate", "diffuse interstitial pulmonary fibrosis" ] ]

Doxycycline-induced photo-onycholysis.

[ [ "Doxycycline", "photo-onycholysis" ] ]

Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.

[ [ "cilastatin", "neutropenic fever" ], [ "imipenem", "neutropenic fever" ] ]

PURPOSE: To report a case of nodular scleritis following alendronate sodium.

[ [ "alendronate sodium", "nodular scleritis" ] ]

When co-trimoxazole was stopped the red cell aplasia resolved.

[ [ "co-trimoxazole", "red cell aplasia" ] ]

Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared.

[ [ "PTU", "ANCA" ] ]

On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.

[ [ "dalteparin", "acute respiratory distress" ] ]

Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.

[ [ "Isoniazid", "pellagra" ] ]

However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.

[ [ "troglitazone", "liver injury" ] ]

Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.

[ [ "sulfasalazine", "positive autoantibodies" ], [ "sulfasalazine", "Pneumonitis" ], [ "sulfasalazine", "cardiac tamponade" ], [ "sulfasalazine", "bilateral pleural effusions" ] ]

Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.

[ [ "cyclophosphamide", "Subglottic stenosis" ] ]

Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.

[ [ "CDDP", "SIADH" ] ]

Venlafaxine-induced urinary incontinence resolved after switching to sertraline.

[ [ "Venlafaxine", "urinary incontinence" ] ]

Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.

[ [ "mefloquine", "hypoglycaemia" ] ]

Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.

[ [ "cisplatin", "Anaphylaxis" ] ]

DISCUSSION: After exclusion of other causes, the onset of thrombocytopenia after administration of lansoprazole, the resolution of the adverse reaction after discontinuation of the drug, and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole.

[ [ "lansoprazole", "thrombocytopenic" ], [ "lansoprazole", "thrombocytopenia" ] ]

Erosion of psoriatic plaques: an early sign of methotrexate toxicity.

[ [ "methotrexate", "Erosion of psoriatic plaques" ], [ "methotrexate", "methotrexate toxicity" ] ]

A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.

[ [ "oolong tea", "delirious" ] ]

Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.

[ [ "Para-aminosalicylic acid", "hypoglycaemia" ] ]

Protamine allergy as a complication of insulin hypersensitivity: A case report.

[ [ "insulin", "Protamine allergy" ] ]

Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.

[ [ "IFN-alpha", "autoimmune thyroiditis" ], [ "IFN-alpha", "thyroid disorders" ] ]

Voriconazole (VRC) has not previously been reported to cause angio-oedema.

[ [ "VRC", "angio-oedema" ], [ "Voriconazole", "angio-oedema" ] ]

Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.

[ [ "IFN beta", "Grade 3 hepatotoxicity" ] ]

We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.

[ [ "sibutramine", "hyponatremia" ] ]

Anisocoria from transdermal scopolamine.

[ [ "scopolamine", "Anisocoria" ] ]

Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.

[ [ "Doxorubicin", "cardiotoxicity" ] ]

Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.

[ [ "tamoxifen", "Ovarian endometrioid adenocarcinoma" ] ]

To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.

[ [ "captopril", "pemphigus" ] ]

CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.

[ [ "lansoprazole", "thrombocytopenia" ] ]

Ketanserin in the treatment of protamine-induced pulmonary hypertension.

[ [ "protamine", "pulmonary hypertension" ] ]

Tetany in a child with AIDS receiving intravenous tobramycin.

[ [ "tobramycin", "Tetany" ] ]

Scleroderma in association with the use of bleomycin: a report of 3 cases.

[ [ "bleomycin", "Scleroderma" ] ]

Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.

[ [ "lithium", "delirious" ] ]

After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.

[ [ "metamizole", "sepsis" ] ]

It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.

[ [ "methotrexate", "diffuse interstitial pulmonary fibrosis" ] ]

We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.

[ [ "phenol", "acute unilateral total visual loss" ] ]

Temozolomide was restarted 2 months later; the patient again developed a fever.

[ [ "Temozolomide", "fever" ] ]

A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.

[ [ "dapsone", "reversal reaction" ], [ "rifampin", "reversal reaction" ] ]

Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.

[ [ "calcium hopantenate", "pantothenic acid deficiency" ], [ "calcium hopantenate", "Reye-like syndrome" ] ]

We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.

[ [ "disulfiram", "fatal fulminant hepatitis" ] ]

This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.

[ [ "TMP-SMX", "hypersensitivity syndrome" ] ]

Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre".

[ [ "sweet spirits of nitre", "Sudden death" ] ]

Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.

[ [ "magnesium", "magnesium toxicosis" ], [ "magnesium sulfate", "magnesium toxicosis" ] ]

Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.

[ [ "cladribine", "Systemic vasculitis" ] ]

The patient suffered a life-threatening anaphylactoid reaction to amifostine.

[ [ "amifostine", "life-threatening anaphylactoid reaction" ] ]

The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.

[ [ "valproic acid", "FVS" ] ]

Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.

[ [ "trihexyphenidyl", "acute respiratory difficulties" ], [ "trihexyphenidyl", "cranial dystonia" ], [ "trihexyphenidyl", "inspiratory stridor" ] ]

During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.

[ [ "terlipressin", "torsade de pointes" ], [ "terlipressin", "prolonged QT interval" ] ]

Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.

[ [ "pegylated interferon alpha", "Acute dystonia" ] ]

Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.

[ [ "amphotericin B deoxycholate", "cardiac toxicity" ] ]

There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.

[ [ "ribavirin", "granulomatosis" ], [ "interferon alfa", "granulomatosis" ] ]

We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.

[ [ "nimesulide", "AGEP" ], [ "nimesulide", "acute generalized exanthematous pustulosis" ] ]

Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.

[ [ "paclitaxel", "lung fibrosis" ], [ "paclitaxel", "pneumonitis" ] ]

Development of Peyronie's disease during long-term colchicine treatment.

[ [ "colchicine", "Peyronie's disease" ] ]

Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.

[ [ "levamisole", "Cerebral demyelinating disease" ] ]

Corneal endothelial dysfunction associated with amantadine toxicity.

[ [ "amantadine", "Corneal endothelial dysfunction" ] ]

Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.

[ [ "trazodone", "movement disorder" ] ]

However, we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function.

[ [ "ethambutol", "toxic optic neuropathies" ], [ "ethambutol", "visual loss" ] ]

Due to the severity of the rash, temozolomide was permanently discontinued.

[ [ "temozolomide", "rash" ] ]

Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.

[ [ "rifampin", "tubular and interstitial lesions" ] ]

OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.

[ [ "succinylcholine", "fatal hyperkalemia" ] ]

Bone formation induced in an infant by systemic prostaglandin-E2 administration.

[ [ "prostaglandin-E2", "Bone formation" ] ]

When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.

[ [ "isoniazid", "histamine reaction" ] ]

The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.

[ [ "colchicine", "corneal ulcers refractory to conventional treatment" ] ]