harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.	[ [ "heparin", "recurrent arteriothromboses" ], [ "heparin", "acute renal failure" ], [ "heparin", "thrombocytopenia" ], [ "heparin", "HAT" ] ]
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.	[ [ "methotrexate", "Progressive interstitial fibrosis" ] ]
Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.	[ [ "salazosulfapyridine", "Acute generalized exanthematous pustulosis" ] ]
To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.	[ [ "penicillamine", "neurologic disease" ], [ "penicillamine", "neurologic worsening" ] ]
A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.	[ [ "Danazol", "liver damage" ] ]
The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.	[ [ "zomepirac", "anaphylactoid reaction" ] ]
We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.	[ [ "azathioprine", "myelosuppression" ] ]
This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.	[ [ "heparin", "thrombosis" ], [ "heparin", "thrombocytopenia" ] ]
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.	[ [ "zonisamide", "Acute kidney injury" ], [ "zonisamide", "hypersensitivity syndrome" ] ]
Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.	[ [ "MTX", "Pneumonitis" ] ]
These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.	[ [ "ethambutol", "bitemporal visual field defects" ], [ "ethambutol", "mfERG abnormalities" ] ]
We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.	[ [ "valproate", "hypotension" ] ]
Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.	[ [ "Fludarabine", "lung disease" ], [ "fludarabine", "lung disease" ], [ "Fludarabine", "lung toxicity" ] ]
Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.	[ [ "Quinapril", "transient renal impairment" ], [ "Quinapril", "prolonged hypotension" ] ]
Assessment of cortisol response was by insulin-induced hypoglycaemia in three cases, by short tetracosactrin test in two, and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one.	[ [ "insulin", "hypoglycaemia" ] ]
OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.	[ [ "methylphenidate", "fixed drug eruption" ] ]
Cephalexin rash in infectious mononucleosis.	[ [ "Cephalexin", "Cephalexin rash" ] ]
OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).	[ [ "calcineurin", "pain syndrome" ] ]
Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.	[ [ "cytarabine", "central nervous system toxicity" ], [ "methotrexate", "central nervous system toxicity" ] ]
The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.	[ [ "glibenclamide", "oral lesions of PV" ] ]
Localized dyskeratotic plaque with milia associated with sorafenib.	[ [ "sorafenib", "milia" ], [ "sorafenib", "Localized dyskeratotic plaque" ] ]
Large dose of methylphenidate may cause cataract and glaucoma.	[ [ "methylphenidate", "glaucoma" ], [ "methylphenidate", "cataract" ] ]
Albendazole-induced pseudomembranous colitis.	[ [ "Albendazole", "pseudomembranous colitis" ] ]
Risperidone-induced tardive dyskinesia.	[ [ "Risperidone", "tardive dyskinesia" ] ]
Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.	[ [ "INH", "lichenoid eruption" ], [ "INH", "anagen effluvium" ] ]
Ischaemic colitis in a patient taking meloxicam.	[ [ "meloxicam", "Ischaemic colitis" ] ]
Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.	[ [ "PTU", "Acute hepatic failure" ], [ "propylthiouracil", "Acute hepatic failure" ] ]
Chloroquine-induced bilateral ptosis.	[ [ "Chloroquine", "bilateral ptosis" ] ]
Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.	[ [ "cyanamide", "fever" ], [ "cyanamide", "fatigue" ] ]
We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.	[ [ "quetiapine", "suicidal overdose deaths" ] ]
A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.	[ [ "suxamethonium", "apnoea" ] ]
After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.	[ [ "HCQ", "ventricular tachycardia" ] ]
The following is a report of 2 cases of rifampicin-induced renal insufficiency.	[ [ "rifampicin", "renal insufficiency" ] ]
OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.	[ [ "vinorelbine", "syndrome of inappropriate antidiuretic hormone" ], [ "vinorelbine", "SIADH" ] ]
We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.	[ [ "itraconazole", "vanishing bile duct syndrome" ] ]
A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.	[ [ "Amphojel", "small-bowel obstruction" ] ]
Sotalol-induced bradycardia reversed by glucagon.	[ [ "Sotalol", "bradycardia" ] ]
Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.	[ [ "irinotecan", "Neutropenic colitis" ], [ "nedaplatin", "Neutropenic colitis" ] ]
A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.	[ [ "tryptophan", "eosinophilia myalgia syndrome" ] ]
Severe serotonin syndrome induced by mirtazapine monotherapy.	[ [ "mirtazapine", "serotonin syndrome" ] ]
Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.	[ [ "amiodarone", "thyrotoxicosis" ] ]
A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.	[ [ "morphine", "nonconvulsive status epilepticus" ] ]
Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.	[ [ "glatiramer acetate", "Embolia cutis medicamentosa" ] ]
FSGS induced by Adriamycin (Pharmacia & Upjohn, Columbus, OH) has been observed experimentally in rats.	[ [ "Adriamycin", "FSGS" ] ]
We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.	[ [ "muzolimine", "fatal neuromyeloencephalopathy" ] ]
Two cases of mequitazine-induced photosensitivity reactions.	[ [ "mequitazine", "photosensitivity reactions" ] ]
Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.	[ [ "ifosfamide", "Toxicity" ] ]
Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.	[ [ "cyclosporin", "thrombosis of the central retinal vein" ], [ "cyclosporin", "Cholelithiasis" ] ]
We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.	[ [ "adenosine", "sustained monomorphic ventricular tachycardia" ] ]
In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.	[ [ "vincristine", "severe Raynaud's phenomenon" ], [ "vinblastine", "severe Raynaud's phenomenon" ], [ "vinblastine", "gangrene" ], [ "vincristine", "gangrene" ], [ "bleomycin", "gangrene" ], [ "bleomycin", "severe Raynaud's phenomenon" ] ]
We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).	[ [ "infliximab", "severe AVP" ] ]
After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.	[ [ "indapamide", "diabetes" ] ]
Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.	[ [ "diltiazem", "Atrial fibrillation" ], [ "verapamil", "syncope" ] ]
ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.	[ [ "lamivudine", "ADR" ] ]
OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.	[ [ "adalimumab", "splenomegaly" ], [ "adalimumab", "fever" ], [ "adalimumab", "pancytopenia" ], [ "adalimumab", "extreme hyperferritinemia" ] ]
Gentamicin-associated acute renal failure.	[ [ "Gentamicin", "acute renal failure" ] ]
They continued to rise for five more days before salicylate hepatotoxicity was suspected.	[ [ "salicylate", "hepatotoxicity" ] ]
Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.	[ [ "terbutaline", "Pulmonary edema" ], [ "ritodrine", "Pulmonary edema" ] ]
The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.	[ [ "cefoxitin", "acute tubular necrosis" ], [ "gentamicin", "acute tubular necrosis" ] ]
DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.	[ [ "5-FU", "ectropion" ], [ "5-FU", "tender, red, scaled lids" ] ]
The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.	[ [ "propranolol", "central nervous system disturbances" ] ]
Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.	[ [ "thalidomide", "Sustained ventricular tachycardia" ] ]
We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.	[ [ "sulfasalazine", "IBD" ] ]
Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.	[ [ "FK506", "speech loss" ] ]
We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.	[ [ "ifosfamide", "ifosfamide-induced encephalopathy" ] ]
Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.	[ [ "dextrose", "increased histamine release" ] ]
She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.	[ [ "Pancrease MT 16", "vomiting" ] ]
Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.	[ [ "reserpine", "reserpine toxicity" ] ]
We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.	[ [ "vincristine", "severe motor neuropathy" ] ]
We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.	[ [ "pFVIII", "thrombotic left middle cerebral artery distribution stroke" ] ]
DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.	[ [ "clindamycin", "C. difficile toxin in stool" ], [ "clindamycin", "diarrhea" ] ]
In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.	[ [ "SP", "hypoglycaemic coma" ] ]
Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.	[ [ "Actinomycin D", "hepatic veno-occlusive disease" ] ]
This pattern is suggestive of renal toxicity due to tobramycin.	[ [ "tobramycin", "renal toxicity" ] ]
A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.	[ [ "prednisone", "diabetes mellitus" ], [ "azathioprine", "diabetes mellitus" ], [ "prednisone", "exocrine pancreatic insufficiency" ], [ "azathioprine", "exocrine pancreatic insufficiency" ] ]
DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.	[ [ "etanercept", "tuberculous uveitis" ] ]
Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.	[ [ "cytosine arabinoside", "Peripheral nerve dysfunction" ] ]
The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.	[ [ "rituximab", "acute coronary syndrome" ] ]
Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.	[ [ "methylephedrine", "stroke" ] ]
Methotrexate-induced papular eruption following treatment of psoriasis.	[ [ "Methotrexate", "papular eruption" ] ]
Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.	[ [ "Pseudoephedrine", "hemorrhage" ], [ "Pseudoephedrine", "cerebral vascular malformation" ] ]
We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.	[ [ "sargramostim", "Sweet's syndrome" ] ]
The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.	[ [ "risperidone", "dystonia" ] ]
In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.	[ [ "tacrolimus", "RSDS" ], [ "CyA", "RSDS" ] ]
We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.	[ [ "dexamethasone", "infectious toxicities" ], [ "dexamethasone", "infectious complications" ] ]
Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.	[ [ "Methylphenidate", "enuresis" ] ]
Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.	[ [ "bleomycin", "Raynaud's phenomenon" ], [ "bleomycin", "acral necrosis" ] ]
a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.	[ [ "lithium carbonate", "Creutzfeldt-Jakob like syndrome" ] ]
Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.	[ [ "Carboplatin", "coronary vasospasm" ] ]
CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.	[ [ "CS", "cutaneous leishmaniasis" ], [ "CS", "Leishmania infantum leishmaniasis" ], [ "corticosteroid", "lingual leishmaniasis" ], [ "corticosteroid", "Leishmania infantum leishmaniasis" ], [ "CS", "lingual leishmaniasis" ] ]
DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.	[ [ "ifosfamide", "Central nervous system (CNS) toxicity" ] ]
METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.	[ [ "gemcitabine", "HUS" ] ]
Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.	[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "syndrome of inappropriate antidiuretic hormone" ] ]
Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.	[ [ "vancomycin", "vancomycin toxicity" ] ]
We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.	[ [ "cyclosporine", "Nocardia Asteroides brain abscess" ], [ "prednisone", "Nocardia Asteroides brain abscess" ] ]
Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.	[ [ "streptokinase", "Thrombo-embolic complication" ] ]
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.	[ [ "propylthiouracil", "agranulocytosis" ] ]
In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.	[ [ "interferon alpha", "polymyositis" ], [ "interferon alpha", "cardiomyopathy" ] ]
We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.	[ [ "captopril", "transient anuria" ], [ "captopril", "acute renal impairment" ] ]
Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.	[ [ "haloperidol", "Extrapyramidal symptoms" ] ]

A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.

[ [ "heparin", "recurrent arteriothromboses" ], [ "heparin", "acute renal failure" ], [ "heparin", "thrombocytopenia" ], [ "heparin", "HAT" ] ]

Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.

[ [ "methotrexate", "Progressive interstitial fibrosis" ] ]

Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.

[ [ "salazosulfapyridine", "Acute generalized exanthematous pustulosis" ] ]

To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.

[ [ "penicillamine", "neurologic disease" ], [ "penicillamine", "neurologic worsening" ] ]

A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.

[ [ "Danazol", "liver damage" ] ]

The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.

[ [ "zomepirac", "anaphylactoid reaction" ] ]

We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.

[ [ "azathioprine", "myelosuppression" ] ]

This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.

[ [ "heparin", "thrombosis" ], [ "heparin", "thrombocytopenia" ] ]

Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.

[ [ "zonisamide", "Acute kidney injury" ], [ "zonisamide", "hypersensitivity syndrome" ] ]

Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.

[ [ "MTX", "Pneumonitis" ] ]

These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.

[ [ "ethambutol", "bitemporal visual field defects" ], [ "ethambutol", "mfERG abnormalities" ] ]

We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.

[ [ "valproate", "hypotension" ] ]

Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.

[ [ "Fludarabine", "lung disease" ], [ "fludarabine", "lung disease" ], [ "Fludarabine", "lung toxicity" ] ]

Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.

[ [ "Quinapril", "transient renal impairment" ], [ "Quinapril", "prolonged hypotension" ] ]

Assessment of cortisol response was by insulin-induced hypoglycaemia in three cases, by short tetracosactrin test in two, and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one.

[ [ "insulin", "hypoglycaemia" ] ]

OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.

[ [ "methylphenidate", "fixed drug eruption" ] ]

Cephalexin rash in infectious mononucleosis.

[ [ "Cephalexin", "Cephalexin rash" ] ]

OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).

[ [ "calcineurin", "pain syndrome" ] ]

Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.

[ [ "cytarabine", "central nervous system toxicity" ], [ "methotrexate", "central nervous system toxicity" ] ]

The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.

[ [ "glibenclamide", "oral lesions of PV" ] ]

Localized dyskeratotic plaque with milia associated with sorafenib.

[ [ "sorafenib", "milia" ], [ "sorafenib", "Localized dyskeratotic plaque" ] ]

Large dose of methylphenidate may cause cataract and glaucoma.

[ [ "methylphenidate", "glaucoma" ], [ "methylphenidate", "cataract" ] ]

Albendazole-induced pseudomembranous colitis.

[ [ "Albendazole", "pseudomembranous colitis" ] ]

Risperidone-induced tardive dyskinesia.

[ [ "Risperidone", "tardive dyskinesia" ] ]

Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.

[ [ "INH", "lichenoid eruption" ], [ "INH", "anagen effluvium" ] ]

Ischaemic colitis in a patient taking meloxicam.

[ [ "meloxicam", "Ischaemic colitis" ] ]

Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.

[ [ "PTU", "Acute hepatic failure" ], [ "propylthiouracil", "Acute hepatic failure" ] ]

Chloroquine-induced bilateral ptosis.

[ [ "Chloroquine", "bilateral ptosis" ] ]

Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.

[ [ "cyanamide", "fever" ], [ "cyanamide", "fatigue" ] ]

We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.

[ [ "quetiapine", "suicidal overdose deaths" ] ]

A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.

[ [ "suxamethonium", "apnoea" ] ]

After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.

[ [ "HCQ", "ventricular tachycardia" ] ]

The following is a report of 2 cases of rifampicin-induced renal insufficiency.

[ [ "rifampicin", "renal insufficiency" ] ]

OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.

[ [ "vinorelbine", "syndrome of inappropriate antidiuretic hormone" ], [ "vinorelbine", "SIADH" ] ]

We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.

[ [ "itraconazole", "vanishing bile duct syndrome" ] ]

A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.

[ [ "Amphojel", "small-bowel obstruction" ] ]

Sotalol-induced bradycardia reversed by glucagon.

[ [ "Sotalol", "bradycardia" ] ]

Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.

[ [ "irinotecan", "Neutropenic colitis" ], [ "nedaplatin", "Neutropenic colitis" ] ]

A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.

[ [ "tryptophan", "eosinophilia myalgia syndrome" ] ]

Severe serotonin syndrome induced by mirtazapine monotherapy.

[ [ "mirtazapine", "serotonin syndrome" ] ]

Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.

[ [ "amiodarone", "thyrotoxicosis" ] ]

A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.

[ [ "morphine", "nonconvulsive status epilepticus" ] ]

Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.

[ [ "glatiramer acetate", "Embolia cutis medicamentosa" ] ]

FSGS induced by Adriamycin (Pharmacia & Upjohn, Columbus, OH) has been observed experimentally in rats.

[ [ "Adriamycin", "FSGS" ] ]

We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.

[ [ "muzolimine", "fatal neuromyeloencephalopathy" ] ]

Two cases of mequitazine-induced photosensitivity reactions.

[ [ "mequitazine", "photosensitivity reactions" ] ]

Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.

[ [ "ifosfamide", "Toxicity" ] ]

Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.

[ [ "cyclosporin", "thrombosis of the central retinal vein" ], [ "cyclosporin", "Cholelithiasis" ] ]

We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.

[ [ "adenosine", "sustained monomorphic ventricular tachycardia" ] ]

In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.

[ [ "vincristine", "severe Raynaud's phenomenon" ], [ "vinblastine", "severe Raynaud's phenomenon" ], [ "vinblastine", "gangrene" ], [ "vincristine", "gangrene" ], [ "bleomycin", "gangrene" ], [ "bleomycin", "severe Raynaud's phenomenon" ] ]

We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).

[ [ "infliximab", "severe AVP" ] ]

After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.

[ [ "indapamide", "diabetes" ] ]

Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.

[ [ "diltiazem", "Atrial fibrillation" ], [ "verapamil", "syncope" ] ]

ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.

[ [ "lamivudine", "ADR" ] ]

OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.

[ [ "adalimumab", "splenomegaly" ], [ "adalimumab", "fever" ], [ "adalimumab", "pancytopenia" ], [ "adalimumab", "extreme hyperferritinemia" ] ]

Gentamicin-associated acute renal failure.

[ [ "Gentamicin", "acute renal failure" ] ]

They continued to rise for five more days before salicylate hepatotoxicity was suspected.

[ [ "salicylate", "hepatotoxicity" ] ]

Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.

[ [ "terbutaline", "Pulmonary edema" ], [ "ritodrine", "Pulmonary edema" ] ]

The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.

[ [ "cefoxitin", "acute tubular necrosis" ], [ "gentamicin", "acute tubular necrosis" ] ]

DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.

[ [ "5-FU", "ectropion" ], [ "5-FU", "tender, red, scaled lids" ] ]

The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.

[ [ "propranolol", "central nervous system disturbances" ] ]

Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.

[ [ "thalidomide", "Sustained ventricular tachycardia" ] ]

We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.

[ [ "sulfasalazine", "IBD" ] ]

Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.

[ [ "FK506", "speech loss" ] ]

We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.

[ [ "ifosfamide", "ifosfamide-induced encephalopathy" ] ]

Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.

[ [ "dextrose", "increased histamine release" ] ]

She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.

[ [ "Pancrease MT 16", "vomiting" ] ]

Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.

[ [ "reserpine", "reserpine toxicity" ] ]

We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.

[ [ "vincristine", "severe motor neuropathy" ] ]

We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.

[ [ "pFVIII", "thrombotic left middle cerebral artery distribution stroke" ] ]

DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.

[ [ "clindamycin", "C. difficile toxin in stool" ], [ "clindamycin", "diarrhea" ] ]

In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.

[ [ "SP", "hypoglycaemic coma" ] ]

Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.

[ [ "Actinomycin D", "hepatic veno-occlusive disease" ] ]

This pattern is suggestive of renal toxicity due to tobramycin.

[ [ "tobramycin", "renal toxicity" ] ]

A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.

[ [ "prednisone", "diabetes mellitus" ], [ "azathioprine", "diabetes mellitus" ], [ "prednisone", "exocrine pancreatic insufficiency" ], [ "azathioprine", "exocrine pancreatic insufficiency" ] ]

DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.

[ [ "etanercept", "tuberculous uveitis" ] ]

Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.

[ [ "cytosine arabinoside", "Peripheral nerve dysfunction" ] ]

The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.

[ [ "rituximab", "acute coronary syndrome" ] ]

Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.

[ [ "methylephedrine", "stroke" ] ]

Methotrexate-induced papular eruption following treatment of psoriasis.

[ [ "Methotrexate", "papular eruption" ] ]

Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.

[ [ "Pseudoephedrine", "hemorrhage" ], [ "Pseudoephedrine", "cerebral vascular malformation" ] ]

We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.

[ [ "sargramostim", "Sweet's syndrome" ] ]

The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.

[ [ "risperidone", "dystonia" ] ]

In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.

[ [ "tacrolimus", "RSDS" ], [ "CyA", "RSDS" ] ]

We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.

[ [ "dexamethasone", "infectious toxicities" ], [ "dexamethasone", "infectious complications" ] ]

Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.

[ [ "Methylphenidate", "enuresis" ] ]

Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.

[ [ "bleomycin", "Raynaud's phenomenon" ], [ "bleomycin", "acral necrosis" ] ]

a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.

[ [ "lithium carbonate", "Creutzfeldt-Jakob like syndrome" ] ]

Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.

[ [ "Carboplatin", "coronary vasospasm" ] ]

CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.

[ [ "CS", "cutaneous leishmaniasis" ], [ "CS", "Leishmania infantum leishmaniasis" ], [ "corticosteroid", "lingual leishmaniasis" ], [ "corticosteroid", "Leishmania infantum leishmaniasis" ], [ "CS", "lingual leishmaniasis" ] ]

DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.

[ [ "ifosfamide", "Central nervous system (CNS) toxicity" ] ]

METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.

[ [ "gemcitabine", "HUS" ] ]

Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.

[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "syndrome of inappropriate antidiuretic hormone" ] ]

Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.

[ [ "vancomycin", "vancomycin toxicity" ] ]

We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.

[ [ "cyclosporine", "Nocardia Asteroides brain abscess" ], [ "prednisone", "Nocardia Asteroides brain abscess" ] ]

Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.

[ [ "streptokinase", "Thrombo-embolic complication" ] ]

A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.

[ [ "propylthiouracil", "agranulocytosis" ] ]

In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.

[ [ "interferon alpha", "polymyositis" ], [ "interferon alpha", "cardiomyopathy" ] ]

We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.

[ [ "captopril", "transient anuria" ], [ "captopril", "acute renal impairment" ] ]

Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.

[ [ "haloperidol", "Extrapyramidal symptoms" ] ]