harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Large cerebral infarction during praziquantel therapy in neurocysticercosis.	[ [ "praziquantel", "Large cerebral infarction" ] ]
The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.	[ [ "Miacalcic", "anaphylactic reaction" ] ]
Sarcoma complicating therapy with cyclophosphamide.	[ [ "cyclophosphamide", "Sarcoma" ] ]
Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.	[ [ "chloramphenicol", "Hypersensitivity reactions" ] ]
Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.	[ [ "alprazolam", "manic episodes" ] ]
Tardive oculogyric crisis during treatment with clozapine: report of three cases.	[ [ "clozapine", "Tardive oculogyric crisis" ] ]
A case of noncardiogenic pulmonary edema by ethanolamine oleate.	[ [ "ethanolamine oleate", "noncardiogenic pulmonary edema" ] ]
Clonidine-induced bradycardia in patients with spinal cord injury.	[ [ "Clonidine", "bradycardia" ] ]
Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.	[ [ "flunitrazepam", "Acute ischaemia of the leg" ] ]
These cases demonstrate that CBZ can induce simple motor tics in children.	[ [ "CBZ", "motor tics" ] ]
New onset of CD may be considered as an immune-mediated injury induced by etanercept.	[ [ "etanercept", "CD" ], [ "etanercept", "immune-mediated injury" ] ]
L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.	[ [ "L-asparaginase", "severe necrotizing pancreatitis" ] ]
This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.	[ [ "mefloquine", "diffuse alveolar damage" ], [ "mefloquine", "acute lung injury" ] ]
Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.	[ [ "interferon-alpha", "Hyperpigmentation" ] ]
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.	[ [ "Tenofovir", "nephrotoxicity" ] ]
Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.	[ [ "sorbitol", "colonic perforation" ], [ "calcium polystyrene sulfonate", "colonic perforation" ] ]
Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.	[ [ "calcium polystryrene sulfonate", "Colonic mucosal necrosis" ], [ "Kalimate", "Colonic mucosal necrosis" ] ]
After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.	[ [ "vitamin D3", "serum level of calcium and urinary excretion of calcium increased" ] ]
However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.	[ [ "adenosine", "acceleration of the ventricular rate" ] ]
Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.	[ [ "propylthiouracil", "hepatitis" ], [ "propylthiouracil", "eosinophilia" ], [ "propylthiouracil", "skin reaction" ], [ "propylthiouracil", "granulocytopenia" ], [ "propylthiouracil", "lymphocyte sensitization" ] ]
We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.	[ [ "vinblastine", "inappropriate secretion of antidiuretic hormone" ] ]
OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.	[ [ "human insulin", "lipoatrophy" ] ]
The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.	[ [ "PGE1", "gastric mucosa foveolar hyperplasia" ] ]
Life-threatening hyperkalemia induced by arginine.	[ [ "arginine", "hyperkalemia" ] ]
We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.	[ [ "tamoxifen", "endometrial cancer" ] ]
Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.	[ [ "paclitaxel", "Fatal pulmonary fibrosis" ] ]
Ticlopidine-induced interstitial pulmonary disease: a case report.	[ [ "Ticlopidine", "interstitial pulmonary disease" ] ]
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.	[ [ "nitrous oxide", "Neurologic degeneration" ] ]
Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.	[ [ "Benzocaine", "methemoglobinemia" ] ]
OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.	[ [ "ifosfamide", "nonconvulsive status epilepticus" ] ]
Physicians should be aware of the potentially lethal side effects of dapsone.	[ [ "dapsone", "lethal" ] ]
Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.	[ [ "cloxacillin", "Allergy" ] ]
Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.	[ [ "hydroxychloroquine", "retinal toxicity" ] ]
It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.	[ [ "tazobactam", "thrombocytosis" ], [ "piperacillin", "thrombocytosis" ], [ "ciprofloxacin", "thrombocytosis" ] ]
Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.	[ [ "clozapine", "agranulocytosis" ], [ "clozapine", "Granulocytopenia" ] ]
We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).	[ [ "M-CSF", "nephrotic syndrome" ], [ "macrophage-colony-stimulating factor", "nephrotic syndrome" ] ]
Choroidal hemorrhage associated with systemic tissue plasminogen activator.	[ [ "tissue plasminogen activator", "Choroidal hemorrhage" ] ]
Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).	[ [ "propylthiouracil", "elevated hepatic enzymes" ], [ "PTU", "elevated hepatic enzymes" ] ]
We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.	[ [ "quinapril", "cough" ] ]
Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.	[ [ "5-fluorouracil", "severe adverse reactions" ] ]
In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.	[ [ "IFN-alpha", "subacute thyroiditis" ], [ "IFN-alpha", "Graves' disease" ] ]
Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.	[ [ "chlorambucil", "respiratory distress" ] ]
Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.	[ [ "rituximab", "BOOP" ] ]
Reversible sirolimus-associated pneumonitis after heart transplantation.	[ [ "sirolimus", "pneumonitis" ] ]
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.	[ [ "Phenytoin", "cerebellar syndrome" ] ]
Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.	[ [ "IFN-alpha", "hyperthyroidism" ] ]
We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.	[ [ "garenoxacin", "Torsades de Pointes" ], [ "garenoxacin", "TdP" ], [ "garenoxacin", "ventricular tachycardia" ] ]
The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.	[ [ "AZA", "leukopenia" ] ]
Scleritis complicating zoledronic acid infusion.	[ [ "zoledronic acid", "Scleritis" ] ]
None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.	[ [ "doxorubicin", "cardiac arrest" ] ]
The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.	[ [ "D-penicillamine", "rapidly progressive glomerulonephritis" ] ]
Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.	[ [ "gemfibrozil", "eosinophilic gastroenteritis" ] ]
Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.	[ [ "Itraconazole", "vincristine neurotoxicity" ], [ "vincristine", "vincristine neurotoxicity" ] ]
We report four cases of severe corneal ulceration in methamphetamine abusers.	[ [ "methamphetamine", "severe corneal ulceration" ] ]
Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.	[ [ "uracil-tegafur", "Scleroderma-like reaction" ], [ "UFT", "Scleroderma-like reaction" ] ]
DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.	[ [ "lovastatin", "rhabdomyolysis" ] ]
A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.	[ [ "levomepromazine", "fatal pancytopenia" ], [ "diazepam", "fatal pancytopenia" ], [ "lithium carbonate", "fatal pancytopenia" ] ]
Unusual hypersensitivity to warfarin in a critically ill patient.	[ [ "warfarin", "hypersensitivity" ] ]
Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.	[ [ "methicillin", "nephropathy" ] ]
CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.	[ [ "propafenone", "mild cognitive impairment" ] ]
We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.	[ [ "ofloxacin", "seizures" ] ]
She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.	[ [ "desferrioxamine", "liver failure" ], [ "desferrioxamine", "congestive heart failure" ], [ "desferrioxamine", "haemosiderosis" ] ]
CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.	[ [ "quinacrine", "severe maculopathy" ], [ "chloroquine", "maculopathy" ] ]
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).	[ [ "disopyramide phosphate", "complete heart block" ], [ "Norpace", "complete heart block" ], [ "disopyramide phosphate", "CHB" ], [ "Norpace", "CHB" ] ]
Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.	[ [ "immunoglobulin", "Acute renal failure" ] ]
Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.	[ [ "heparin", "venous thromboembolism" ] ]
Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.	[ [ "HU", "increase in total Hb" ] ]
This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.	[ [ "lamotrigine", "localized purpura" ] ]
Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.	[ [ "folinic acid", "hypocalcaemia" ], [ "methotrexate", "hyperkalaemia" ], [ "folinic acid", "hyperphosphataemia" ], [ "methotrexate", "tetany" ], [ "folinic acid", "acute renal impairment" ], [ "folinic acid", "tetany" ], [ "methotrexate", "hyper-uricaemia" ], [ "folinic acid", "hyperkalaemia" ], [ "folinic acid", "phosphate shower syndrome" ], [ "methotrexate", "hyperphosphataemia" ], [ "folinic acid", "hyper-uricaemia" ], [ "methotrexate", "hypocalcaemia" ], [ "folinic acid", "metabolic acidosis" ], [ "methotrexate", "acute renal impairment" ], [ "methotrexate", "metabolic acidosis" ], [ "methotrexate", "phosphate shower syndrome" ] ]
Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.	[ [ "hepatitis B vaccination", "acute transverse myelitis" ] ]
The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.	[ [ "penicillamine", "optic neuropathy" ] ]
Amoxapine-induced cognitive impairment in two patients.	[ [ "Amoxapine", "cognitive impairment" ] ]
A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.	[ [ "halothane", "hepatitis" ] ]
We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.	[ [ "erlotinib", "fatal pulmonary toxicity" ] ]
There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.	[ [ "atomoxetine", "tics" ] ]
We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.	[ [ "acyclovir", "neurotoxicity" ] ]
We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.	[ [ "etanercept", "CD" ] ]
However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.	[ [ "tamoxifen", "endometrial carcinoma" ] ]
A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.	[ [ "cinepazide", "behavioral change" ] ]
The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.	[ [ "colchicine", "corneal ulcers refractory to conventional treatment" ] ]
A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.	[ [ "busulphan", "oesophageal varices" ], [ "busulphan", "jaundice" ], [ "busulphan", "ascites" ], [ "busulphan", "portal hypertension" ] ]
Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.	[ [ "chromic phosphate", "bowel injury" ] ]
DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.	[ [ "AZA", "allergy" ] ]
CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.	[ [ "INH", "neurotoxicity" ] ]
Acute pancreatitis after long-term 5-aminosalicylic acid therapy.	[ [ "5-aminosalicylic acid", "Acute pancreatitis" ] ]
Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.	[ [ "phenytoin", "swelling of the face and legs" ], [ "phenytoin", "pruritus" ] ]
Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.	[ [ "SQ 14225", "Transient anuria" ] ]
Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.	[ [ "aspirin", "hemorrhage" ] ]
Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.	[ [ "budesonide", "Contact dermatitis" ] ]
Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).	[ [ "theophylline", "reaction to the drug became more toxic" ] ]
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.	[ [ "ritonavir", "bipolar disorder" ], [ "valproic Acid", "bipolar disorder" ], [ "lopinavir", "bipolar disorder" ] ]
In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.	[ [ "colchicine", "myopathy" ] ]
Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.	[ [ "Thrombin", "cerebral infarctions" ] ]
Acute pancreatitis is a known, although rare, complication of mesalamine treatment.	[ [ "mesalamine", "Acute pancreatitis" ] ]
A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.	[ [ "minoxidil", "fatal interaction" ] ]
Development of porphyria cutanea tarda after treatment with cyclophosphamide.	[ [ "cyclophosphamide", "porphyria cutanea tarda" ] ]
Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.	[ [ "vincristine", "severe neurotoxicity" ] ]
We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.	[ [ "meloxicam", "intestinal toxic effects" ] ]
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.	[ [ "dexamethasone", "bilateral avascular necrosis of the femoral heads" ] ]
One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.	[ [ "risperidone", "feeding gastrostomy" ], [ "risperidone", "worsening parkinsonism" ] ]

Large cerebral infarction during praziquantel therapy in neurocysticercosis.

[ [ "praziquantel", "Large cerebral infarction" ] ]

The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.

[ [ "Miacalcic", "anaphylactic reaction" ] ]

Sarcoma complicating therapy with cyclophosphamide.

[ [ "cyclophosphamide", "Sarcoma" ] ]

Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.

[ [ "chloramphenicol", "Hypersensitivity reactions" ] ]

Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.

[ [ "alprazolam", "manic episodes" ] ]

Tardive oculogyric crisis during treatment with clozapine: report of three cases.

[ [ "clozapine", "Tardive oculogyric crisis" ] ]

A case of noncardiogenic pulmonary edema by ethanolamine oleate.

[ [ "ethanolamine oleate", "noncardiogenic pulmonary edema" ] ]

Clonidine-induced bradycardia in patients with spinal cord injury.

[ [ "Clonidine", "bradycardia" ] ]

Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.

[ [ "flunitrazepam", "Acute ischaemia of the leg" ] ]

These cases demonstrate that CBZ can induce simple motor tics in children.

[ [ "CBZ", "motor tics" ] ]

New onset of CD may be considered as an immune-mediated injury induced by etanercept.

[ [ "etanercept", "CD" ], [ "etanercept", "immune-mediated injury" ] ]

L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.

[ [ "L-asparaginase", "severe necrotizing pancreatitis" ] ]

This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.

[ [ "mefloquine", "diffuse alveolar damage" ], [ "mefloquine", "acute lung injury" ] ]

Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.

[ [ "interferon-alpha", "Hyperpigmentation" ] ]

Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.

[ [ "Tenofovir", "nephrotoxicity" ] ]

Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.

[ [ "sorbitol", "colonic perforation" ], [ "calcium polystyrene sulfonate", "colonic perforation" ] ]

Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.

[ [ "calcium polystryrene sulfonate", "Colonic mucosal necrosis" ], [ "Kalimate", "Colonic mucosal necrosis" ] ]

After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.

[ [ "vitamin D3", "serum level of calcium and urinary excretion of calcium increased" ] ]

However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.

[ [ "adenosine", "acceleration of the ventricular rate" ] ]

Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.

[ [ "propylthiouracil", "hepatitis" ], [ "propylthiouracil", "eosinophilia" ], [ "propylthiouracil", "skin reaction" ], [ "propylthiouracil", "granulocytopenia" ], [ "propylthiouracil", "lymphocyte sensitization" ] ]

We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.

[ [ "vinblastine", "inappropriate secretion of antidiuretic hormone" ] ]

OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.

[ [ "human insulin", "lipoatrophy" ] ]

The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.

[ [ "PGE1", "gastric mucosa foveolar hyperplasia" ] ]

Life-threatening hyperkalemia induced by arginine.

[ [ "arginine", "hyperkalemia" ] ]

We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.

[ [ "tamoxifen", "endometrial cancer" ] ]

Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.

[ [ "paclitaxel", "Fatal pulmonary fibrosis" ] ]

Ticlopidine-induced interstitial pulmonary disease: a case report.

[ [ "Ticlopidine", "interstitial pulmonary disease" ] ]

Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.

[ [ "nitrous oxide", "Neurologic degeneration" ] ]

Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.

[ [ "Benzocaine", "methemoglobinemia" ] ]

OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.

[ [ "ifosfamide", "nonconvulsive status epilepticus" ] ]

Physicians should be aware of the potentially lethal side effects of dapsone.

[ [ "dapsone", "lethal" ] ]

Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.

[ [ "cloxacillin", "Allergy" ] ]

Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.

[ [ "hydroxychloroquine", "retinal toxicity" ] ]

It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.

[ [ "tazobactam", "thrombocytosis" ], [ "piperacillin", "thrombocytosis" ], [ "ciprofloxacin", "thrombocytosis" ] ]

Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.

[ [ "clozapine", "agranulocytosis" ], [ "clozapine", "Granulocytopenia" ] ]

We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).

[ [ "M-CSF", "nephrotic syndrome" ], [ "macrophage-colony-stimulating factor", "nephrotic syndrome" ] ]

Choroidal hemorrhage associated with systemic tissue plasminogen activator.

[ [ "tissue plasminogen activator", "Choroidal hemorrhage" ] ]

Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).

[ [ "propylthiouracil", "elevated hepatic enzymes" ], [ "PTU", "elevated hepatic enzymes" ] ]

We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.

[ [ "quinapril", "cough" ] ]

Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.

[ [ "5-fluorouracil", "severe adverse reactions" ] ]

In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.

[ [ "IFN-alpha", "subacute thyroiditis" ], [ "IFN-alpha", "Graves' disease" ] ]

Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.

[ [ "chlorambucil", "respiratory distress" ] ]

Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.

[ [ "rituximab", "BOOP" ] ]

Reversible sirolimus-associated pneumonitis after heart transplantation.

[ [ "sirolimus", "pneumonitis" ] ]

Phenytoin toxicity: an easily missed cause of cerebellar syndrome.

[ [ "Phenytoin", "cerebellar syndrome" ] ]

Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.

[ [ "IFN-alpha", "hyperthyroidism" ] ]

We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.

[ [ "garenoxacin", "Torsades de Pointes" ], [ "garenoxacin", "TdP" ], [ "garenoxacin", "ventricular tachycardia" ] ]

The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.

[ [ "AZA", "leukopenia" ] ]

Scleritis complicating zoledronic acid infusion.

[ [ "zoledronic acid", "Scleritis" ] ]

None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.

[ [ "doxorubicin", "cardiac arrest" ] ]

The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.

[ [ "D-penicillamine", "rapidly progressive glomerulonephritis" ] ]

Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.

[ [ "gemfibrozil", "eosinophilic gastroenteritis" ] ]

Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.

[ [ "Itraconazole", "vincristine neurotoxicity" ], [ "vincristine", "vincristine neurotoxicity" ] ]

We report four cases of severe corneal ulceration in methamphetamine abusers.

[ [ "methamphetamine", "severe corneal ulceration" ] ]

Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.

[ [ "uracil-tegafur", "Scleroderma-like reaction" ], [ "UFT", "Scleroderma-like reaction" ] ]

DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.

[ [ "lovastatin", "rhabdomyolysis" ] ]

A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.

[ [ "levomepromazine", "fatal pancytopenia" ], [ "diazepam", "fatal pancytopenia" ], [ "lithium carbonate", "fatal pancytopenia" ] ]

Unusual hypersensitivity to warfarin in a critically ill patient.

[ [ "warfarin", "hypersensitivity" ] ]

Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.

[ [ "methicillin", "nephropathy" ] ]

CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.

[ [ "propafenone", "mild cognitive impairment" ] ]

We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.

[ [ "ofloxacin", "seizures" ] ]

She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.

[ [ "desferrioxamine", "liver failure" ], [ "desferrioxamine", "congestive heart failure" ], [ "desferrioxamine", "haemosiderosis" ] ]

CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.

[ [ "quinacrine", "severe maculopathy" ], [ "chloroquine", "maculopathy" ] ]

A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).

[ [ "disopyramide phosphate", "complete heart block" ], [ "Norpace", "complete heart block" ], [ "disopyramide phosphate", "CHB" ], [ "Norpace", "CHB" ] ]

Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.

[ [ "immunoglobulin", "Acute renal failure" ] ]

Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.

[ [ "heparin", "venous thromboembolism" ] ]

Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.

[ [ "HU", "increase in total Hb" ] ]

This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.

[ [ "lamotrigine", "localized purpura" ] ]

Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.

[ [ "folinic acid", "hypocalcaemia" ], [ "methotrexate", "hyperkalaemia" ], [ "folinic acid", "hyperphosphataemia" ], [ "methotrexate", "tetany" ], [ "folinic acid", "acute renal impairment" ], [ "folinic acid", "tetany" ], [ "methotrexate", "hyper-uricaemia" ], [ "folinic acid", "hyperkalaemia" ], [ "folinic acid", "phosphate shower syndrome" ], [ "methotrexate", "hyperphosphataemia" ], [ "folinic acid", "hyper-uricaemia" ], [ "methotrexate", "hypocalcaemia" ], [ "folinic acid", "metabolic acidosis" ], [ "methotrexate", "acute renal impairment" ], [ "methotrexate", "metabolic acidosis" ], [ "methotrexate", "phosphate shower syndrome" ] ]

Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.

[ [ "hepatitis B vaccination", "acute transverse myelitis" ] ]

The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.

[ [ "penicillamine", "optic neuropathy" ] ]

Amoxapine-induced cognitive impairment in two patients.

[ [ "Amoxapine", "cognitive impairment" ] ]

A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.

[ [ "halothane", "hepatitis" ] ]

We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.

[ [ "erlotinib", "fatal pulmonary toxicity" ] ]

There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.

[ [ "atomoxetine", "tics" ] ]

We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.

[ [ "acyclovir", "neurotoxicity" ] ]

We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.

[ [ "etanercept", "CD" ] ]

However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.

[ [ "tamoxifen", "endometrial carcinoma" ] ]

A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.

[ [ "cinepazide", "behavioral change" ] ]

The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.

[ [ "colchicine", "corneal ulcers refractory to conventional treatment" ] ]

A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.

[ [ "busulphan", "oesophageal varices" ], [ "busulphan", "jaundice" ], [ "busulphan", "ascites" ], [ "busulphan", "portal hypertension" ] ]

Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.

[ [ "chromic phosphate", "bowel injury" ] ]

DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.

[ [ "AZA", "allergy" ] ]

CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.

[ [ "INH", "neurotoxicity" ] ]

Acute pancreatitis after long-term 5-aminosalicylic acid therapy.

[ [ "5-aminosalicylic acid", "Acute pancreatitis" ] ]

Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.

[ [ "phenytoin", "swelling of the face and legs" ], [ "phenytoin", "pruritus" ] ]

Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.

[ [ "SQ 14225", "Transient anuria" ] ]

Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.

[ [ "aspirin", "hemorrhage" ] ]

Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.

[ [ "budesonide", "Contact dermatitis" ] ]

Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).

[ [ "theophylline", "reaction to the drug became more toxic" ] ]

Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.

[ [ "ritonavir", "bipolar disorder" ], [ "valproic Acid", "bipolar disorder" ], [ "lopinavir", "bipolar disorder" ] ]

In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.

[ [ "colchicine", "myopathy" ] ]

Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.

[ [ "Thrombin", "cerebral infarctions" ] ]

Acute pancreatitis is a known, although rare, complication of mesalamine treatment.

[ [ "mesalamine", "Acute pancreatitis" ] ]

A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.

[ [ "minoxidil", "fatal interaction" ] ]

Development of porphyria cutanea tarda after treatment with cyclophosphamide.

[ [ "cyclophosphamide", "porphyria cutanea tarda" ] ]

Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.

[ [ "vincristine", "severe neurotoxicity" ] ]

We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.

[ [ "meloxicam", "intestinal toxic effects" ] ]

This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.

[ [ "dexamethasone", "bilateral avascular necrosis of the femoral heads" ] ]

One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.

[ [ "risperidone", "feeding gastrostomy" ], [ "risperidone", "worsening parkinsonism" ] ]