harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Marked elevation of serum creatine kinase associated with olanzapine therapy.	[ [ "olanzapine", "elevation of serum creatine kinase" ] ]
Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.	[ [ "lithium", "Secondary hyperparathyroidism" ], [ "lithium", "nephrotoxicity" ] ]
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).	[ [ "cytosine arabinoside", "TEN" ], [ "ARA-C", "TEN" ], [ "ARA-C", "toxic epidermal necrolysis" ], [ "cytosine arabinoside", "toxic epidermal necrolysis" ] ]
While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.	[ [ "doxorubicin", "breathing distress" ], [ "doxorubicin", "thoracic pain" ] ]
The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.	[ [ "IFN-beta", "refractory pre-patellar bursitis" ], [ "IFN-beta", "autoimmune thyroid disease" ] ]
A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.	[ [ "diamorphine", "painful, oedematous, cyanosed hand" ], [ "methylphenidate", "painful, oedematous, cyanosed hand" ] ]
Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.	[ [ "methazolamide", "agranulocytosis" ], [ "methazolamide", "Aplastic anemia" ] ]
We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.	[ [ "colchicine", "acute weakness" ], [ "simvastatin", "acute weakness" ], [ "simvastatin", "mild chronic renal insufficiency" ] ]
A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.	[ [ "nortriptyline", "sinus tachycardia" ] ]
We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).	[ [ "BCNU", "severe pulmonary fibrosis" ] ]
Clofazimine induced nail changes.	[ [ "Clofazimine", "nail changes" ] ]
Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.	[ [ "BCNU", "Fatal pulmonary fibrosis" ], [ "1,3-bis(2-chloroethyl)-1-nitrosourea", "Fatal pulmonary fibrosis" ] ]
Vortex keratopathy associated with atovaquone.	[ [ "atovaquone", "Vortex keratopathy" ] ]
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.	[ [ "vancomycin", "vancomycin toxicity" ] ]
We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.	[ [ "olanzapine", "photo-onycholysis" ] ]
BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.	[ [ "ribavirin", "retinopathy" ], [ "pegylated interferon", "retinopathy" ] ]
Toxic optic neuropathy associated with ethambutol: implications for current therapy.	[ [ "ethambutol", "Toxic optic neuropathy" ] ]
An unusual cause of burn injury: unsupervised use of drugs that contain psoralens.	[ [ "burn injury", "psoralens" ] ]
CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.	[ [ "betamethasone", "acute pancreatitis" ], [ "roxithromycin", "acute pancreatitis" ] ]
We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.	[ [ "carbamazepine", "hyponatremia" ] ]
Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes.	[ [ "phenytoin", "dermatologic, lymphoid, or hepatic syndromes" ], [ "phenytoin", "hypersensitivity reactions" ] ]
A patient developed optic neuropathy while being treated with isoniazid and ethambutol.	[ [ "isoniazid", "optic neuropathy" ], [ "ethambutol", "optic neuropathy" ] ]
Physicians should be aware that PLP can occur after initiation of paclitaxel.	[ [ "paclitaxel", "PLP" ] ]
This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.	[ [ "tiagabine", "VFDs" ], [ "tiagabine", "visual field defects" ] ]
Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.	[ [ "captopril", "Acute renal failure" ] ]
A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.	[ [ "clozapine", "heatstroke" ] ]
We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.	[ [ "cyclophosphamide", "human teratogen" ] ]
Dapsone-induced erythroderma with Beau's lines.	[ [ "Dapsone", "erythroderma" ] ]
The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.	[ [ "etoposide", "sAML" ] ]
DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.	[ [ "foscarnet", "Electrolyte disorders" ] ]
A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).	[ [ "NBD-Cl", "acute allergic contact dermatitis" ], [ "4-chloro-7-nitrobenzofurazan", "acute allergic contact dermatitis" ] ]
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.	[ [ "MTX", "hematopoietic toxicity" ], [ "MTX", "immunosuppression" ], [ "MTX", "EBV-associated lymphoproliferative disease" ] ]
STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.	[ [ "doxorubicin", "toxic myelopathy" ] ]
We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.	[ [ "valproate", "hepatotoxic effects" ], [ "valproate", "fatal" ] ]
We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.	[ [ "AZ", "hemorrhagic gastritis" ], [ "AZ", "destroyed the gastric mucosal barrier" ], [ "AZ", "thrombocytopenia due to bone marrow disorder" ] ]
Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).	[ [ "B663", "Intra-neural ceroid-like pigment" ], [ "Lamprene", "Intra-neural ceroid-like pigment" ], [ "clofazimine", "Intra-neural ceroid-like pigment" ] ]
Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.	[ [ "penicillamine", "Thrombotic thrombocytopenic purpura" ] ]
Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.	[ [ "fluoxetine", "REM sleep behavior disorder" ], [ "fluoxetine", "Prominent eye movements during NREM sleep" ] ]
We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).	[ [ "methimazole", "AA" ] ]
Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.	[ [ "phenobarbital", "Skin rash" ], [ "phenobarbital", "hepatocellular failure" ] ]
A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.	[ [ "quinine", "transient tonic pupillary response" ], [ "quinine", "abnormal visual-evoked potentials" ], [ "quinine", "denervation supersensitivity" ] ]
Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.	[ [ "pentamidine", "cardiotoxicity" ] ]
Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.	[ [ "Naproxen", "transient hearing loss" ], [ "Naproxen", "tinnitus" ] ]
Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.	[ [ "bisphosphonate", "Symptomatic hypocalcaemia" ], [ "bisphosphonate", "renal impairment" ] ]
This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.	[ [ "ifosfamide", "nonconvulsive status epilepticus" ] ]
A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.	[ [ "cyclophosphamide", "circumferential subglottic stenosis" ] ]
Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.	[ [ "nevirapine", "Stevens-Johnson syndrome" ] ]
The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.	[ [ "sulfamethoxazole", "thrombocytopenia" ], [ "trimethoprim", "thrombocytopenia" ], [ "sulfamethoxazole", "fulminant microangiopathic hemolytic anemia" ], [ "trimethoprim", "fulminant microangiopathic hemolytic anemia" ] ]
The literature of vincristine optic nerve toxicity is reviewed.	[ [ "vincristine", "optic nerve toxicity" ] ]
This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.	[ [ "minocycline", "hyperpigmentation" ] ]
We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.	[ [ "mesalazine", "pericarditis" ] ]
Gynecomastia associated with theophylline.	[ [ "theophylline", "Gynecomastia" ] ]
Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.	[ [ "metrifonate", "Seizures" ] ]
Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.	[ [ "aspirin", "Upper gastrointestinal haemorrhage" ], [ "clopidogrel", "Upper gastrointestinal haemorrhage" ] ]
We report three cases of amiodarone-induced torsades de pointe.	[ [ "amiodarone", "torsades de pointe" ] ]
Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.	[ [ "Acetazolamide", "osteomalacia" ] ]
Agranulocytosis during clozapine therapy.	[ [ "clozapine", "Agranulocytosis" ] ]
CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.	[ [ "losartan", "angioedema" ] ]
Osteomyelitis occurring during infliximab treatment of severe psoriasis.	[ [ "infliximab", "Osteomyelitis" ] ]
We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.	[ [ "adenosine", "ventricular fibrillation" ] ]
Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.	[ [ "interferon alfa", "thrombocythemia" ], [ "pentostatin", "thrombocythemia" ] ]
A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.	[ [ "L-T4", "leukopenia" ] ]
This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.	[ [ "prednisolone", "cryptococcal meningitis" ], [ "azathioprine", "cryptococcal meningitis" ] ]
Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.	[ [ "gold", "Neurological side effects" ] ]
Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.	[ [ "fluphenazine decanoate", "extrapyramidal side effects" ] ]
Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.	[ [ "tacrolimus", "HUS" ], [ "tacrolimus", "ARF" ] ]
Acute bilateral phrenic neuropathy following treatment with adalimumab.	[ [ "adalimumab", "Acute bilateral phrenic neuropathy" ] ]
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.	[ [ "imipenem", "seizure" ], [ "cilastatin", "convulsions" ], [ "cilastatin", "seizure" ], [ "imipenem", "convulsions" ] ]
Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.	[ [ "amiodarone", "Nonsustained polymorphous ventricular tachycardia" ] ]
Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.	[ [ "nitrofurantoin", "Bronchiolitis obliterans organising pneumonia" ] ]
The disease predisposes to severe vincristine neurotoxicity.	[ [ "vincristine", "vincristine neurotoxicity" ] ]
After the first oral dose of propranolol, syncope developed together with atrioventricular block.	[ [ "propranolol", "syncope" ], [ "propranolol", "atrioventricular block" ] ]
Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.	[ [ "enoxaparin", "Thrombocytosis" ] ]
Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.	[ [ "Oxygen", "pulmonary toxicity" ], [ "bleomycin", "pulmonary toxicity" ] ]
CONCLUSION: Severe and sustained ocular hypertension may occur after intravitreal ranibizumab.	[ [ "ranibizumab", "sustained ocular hypertension" ] ]
We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.	[ [ "senna", "cholestatic hepatitis" ] ]
Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.	[ [ "vasopressin", "Myoglobinuria" ], [ "vasopressin", "acute renal failure" ] ]
Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.	[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "Seizure" ] ]
We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).	[ [ "minocycline", "autoimmune hepatitis" ] ]
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.	[ [ "lansoprazole", "Pheripheral edema" ], [ "omeprazole", "Pheripheral edema" ], [ "pantoprazole", "Pheripheral edema" ] ]
We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).	[ [ "sodium phosphate", "hyperphosphatemia" ], [ "sodium biphosphate", "hyperphosphatemia" ] ]
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.	[ [ "vigabatrin", "field defects" ] ]
A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.	[ [ "human growth hormone", "Creutzfeldt-Jakob disease" ] ]
Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.	[ [ "diphenhydramine", "cardiotoxicity" ] ]
Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.	[ [ "nortriptyline", "sinus tachycardia" ] ]
OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.	[ [ "INH", "neurotoxicity" ], [ "isoniazid", "neurotoxicity" ] ]
Bleomycin pneumonitis potentiated by oxygen administration.	[ [ "Bleomycin", "pneumonitis" ] ]
The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.	[ [ "cyclosporin", "cholelithiasis" ] ]
Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.	[ [ "Methysergide", "retroperitoneal fibrosis" ] ]
A small initial dose of prazosin ranging from 0.5 to 1 mg has been recommended to avoid the first-dose phenomenon characterized by a sudden and severe drop in blood pressure after the administration of the first dose of prazosin.	[ [ "prazosin", "severe drop in blood pressure" ] ]
Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.	[ [ "nitroglycerin", "Paradoxical pulmonary vasoconstriction" ] ]
Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine.	[ [ "venlafaxine", "Increased ocular pressure" ] ]
Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.	[ [ "ribavirin", "Celiac disease" ], [ "pegylated interferon", "Celiac disease" ] ]
It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.	[ [ "cytarabine", "PPE" ] ]
Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.	[ [ "alendronate sodium", "scleritis" ] ]
Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.	[ [ "Amiodarone hydrochloride", "diffuse pulmonary infiltrates" ], [ "Amiodarone hydrochloride", "dyspnea" ], [ "Amiodarone hydrochloride", "pulmonary toxicity" ], [ "Amiodarone hydrochloride", "cough" ] ]
We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.	[ [ "5-aminosalicylic acid", "pancytopenia" ], [ "Pentasa", "pancytopenia" ] ]
I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.	[ [ "sumatriptan", "cardiac arrest" ] ]
Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.	[ [ "heparin", "thrombocytopenia" ] ]
We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.	[ [ "insulin", "hypoalbuminaemia" ], [ "insulin", "hyperinsulinaemia" ], [ "insulin", "anti-natriuresis" ], [ "insulin", "increased vascular permeability" ], [ "insulin", "insulin insensitivity" ] ]

Marked elevation of serum creatine kinase associated with olanzapine therapy.

[ [ "olanzapine", "elevation of serum creatine kinase" ] ]

Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.

[ [ "lithium", "Secondary hyperparathyroidism" ], [ "lithium", "nephrotoxicity" ] ]

We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).

[ [ "cytosine arabinoside", "TEN" ], [ "ARA-C", "TEN" ], [ "ARA-C", "toxic epidermal necrolysis" ], [ "cytosine arabinoside", "toxic epidermal necrolysis" ] ]

While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.

[ [ "doxorubicin", "breathing distress" ], [ "doxorubicin", "thoracic pain" ] ]

The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.

[ [ "IFN-beta", "refractory pre-patellar bursitis" ], [ "IFN-beta", "autoimmune thyroid disease" ] ]

A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.

[ [ "diamorphine", "painful, oedematous, cyanosed hand" ], [ "methylphenidate", "painful, oedematous, cyanosed hand" ] ]

Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.

[ [ "methazolamide", "agranulocytosis" ], [ "methazolamide", "Aplastic anemia" ] ]

We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.

[ [ "colchicine", "acute weakness" ], [ "simvastatin", "acute weakness" ], [ "simvastatin", "mild chronic renal insufficiency" ] ]

A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.

[ [ "nortriptyline", "sinus tachycardia" ] ]

We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).

[ [ "BCNU", "severe pulmonary fibrosis" ] ]

Clofazimine induced nail changes.

[ [ "Clofazimine", "nail changes" ] ]

Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.

[ [ "BCNU", "Fatal pulmonary fibrosis" ], [ "1,3-bis(2-chloroethyl)-1-nitrosourea", "Fatal pulmonary fibrosis" ] ]

Vortex keratopathy associated with atovaquone.

[ [ "atovaquone", "Vortex keratopathy" ] ]

Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.

[ [ "vancomycin", "vancomycin toxicity" ] ]

We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.

[ [ "olanzapine", "photo-onycholysis" ] ]

BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.

[ [ "ribavirin", "retinopathy" ], [ "pegylated interferon", "retinopathy" ] ]

Toxic optic neuropathy associated with ethambutol: implications for current therapy.

[ [ "ethambutol", "Toxic optic neuropathy" ] ]

An unusual cause of burn injury: unsupervised use of drugs that contain psoralens.

[ [ "burn injury", "psoralens" ] ]

CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.

[ [ "betamethasone", "acute pancreatitis" ], [ "roxithromycin", "acute pancreatitis" ] ]

We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.

[ [ "carbamazepine", "hyponatremia" ] ]

Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes.

[ [ "phenytoin", "dermatologic, lymphoid, or hepatic syndromes" ], [ "phenytoin", "hypersensitivity reactions" ] ]

A patient developed optic neuropathy while being treated with isoniazid and ethambutol.

[ [ "isoniazid", "optic neuropathy" ], [ "ethambutol", "optic neuropathy" ] ]

Physicians should be aware that PLP can occur after initiation of paclitaxel.

[ [ "paclitaxel", "PLP" ] ]

This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.

[ [ "tiagabine", "VFDs" ], [ "tiagabine", "visual field defects" ] ]

Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.

[ [ "captopril", "Acute renal failure" ] ]

A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.

[ [ "clozapine", "heatstroke" ] ]

We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.

[ [ "cyclophosphamide", "human teratogen" ] ]

Dapsone-induced erythroderma with Beau's lines.

[ [ "Dapsone", "erythroderma" ] ]

The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.

[ [ "etoposide", "sAML" ] ]

DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.

[ [ "foscarnet", "Electrolyte disorders" ] ]

A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).

[ [ "NBD-Cl", "acute allergic contact dermatitis" ], [ "4-chloro-7-nitrobenzofurazan", "acute allergic contact dermatitis" ] ]

We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.

[ [ "MTX", "hematopoietic toxicity" ], [ "MTX", "immunosuppression" ], [ "MTX", "EBV-associated lymphoproliferative disease" ] ]

STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.

[ [ "doxorubicin", "toxic myelopathy" ] ]

We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.

[ [ "valproate", "hepatotoxic effects" ], [ "valproate", "fatal" ] ]

We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.

[ [ "AZ", "hemorrhagic gastritis" ], [ "AZ", "destroyed the gastric mucosal barrier" ], [ "AZ", "thrombocytopenia due to bone marrow disorder" ] ]

Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).

[ [ "B663", "Intra-neural ceroid-like pigment" ], [ "Lamprene", "Intra-neural ceroid-like pigment" ], [ "clofazimine", "Intra-neural ceroid-like pigment" ] ]

Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.

[ [ "penicillamine", "Thrombotic thrombocytopenic purpura" ] ]

Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.

[ [ "fluoxetine", "REM sleep behavior disorder" ], [ "fluoxetine", "Prominent eye movements during NREM sleep" ] ]

We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).

[ [ "methimazole", "AA" ] ]

Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.

[ [ "phenobarbital", "Skin rash" ], [ "phenobarbital", "hepatocellular failure" ] ]

A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.

[ [ "quinine", "transient tonic pupillary response" ], [ "quinine", "abnormal visual-evoked potentials" ], [ "quinine", "denervation supersensitivity" ] ]

Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.

[ [ "pentamidine", "cardiotoxicity" ] ]

Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.

[ [ "Naproxen", "transient hearing loss" ], [ "Naproxen", "tinnitus" ] ]

Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.

[ [ "bisphosphonate", "Symptomatic hypocalcaemia" ], [ "bisphosphonate", "renal impairment" ] ]

This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.

[ [ "ifosfamide", "nonconvulsive status epilepticus" ] ]

A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.

[ [ "cyclophosphamide", "circumferential subglottic stenosis" ] ]

Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.

[ [ "nevirapine", "Stevens-Johnson syndrome" ] ]

The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.

[ [ "sulfamethoxazole", "thrombocytopenia" ], [ "trimethoprim", "thrombocytopenia" ], [ "sulfamethoxazole", "fulminant microangiopathic hemolytic anemia" ], [ "trimethoprim", "fulminant microangiopathic hemolytic anemia" ] ]

The literature of vincristine optic nerve toxicity is reviewed.

[ [ "vincristine", "optic nerve toxicity" ] ]

This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.

[ [ "minocycline", "hyperpigmentation" ] ]

We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.

[ [ "mesalazine", "pericarditis" ] ]

Gynecomastia associated with theophylline.

[ [ "theophylline", "Gynecomastia" ] ]

Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.

[ [ "metrifonate", "Seizures" ] ]

Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.

[ [ "aspirin", "Upper gastrointestinal haemorrhage" ], [ "clopidogrel", "Upper gastrointestinal haemorrhage" ] ]

We report three cases of amiodarone-induced torsades de pointe.

[ [ "amiodarone", "torsades de pointe" ] ]

Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.

[ [ "Acetazolamide", "osteomalacia" ] ]

Agranulocytosis during clozapine therapy.

[ [ "clozapine", "Agranulocytosis" ] ]

CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.

[ [ "losartan", "angioedema" ] ]

Osteomyelitis occurring during infliximab treatment of severe psoriasis.

[ [ "infliximab", "Osteomyelitis" ] ]

We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.

[ [ "adenosine", "ventricular fibrillation" ] ]

Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.

[ [ "interferon alfa", "thrombocythemia" ], [ "pentostatin", "thrombocythemia" ] ]

A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.

[ [ "L-T4", "leukopenia" ] ]

This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.

[ [ "prednisolone", "cryptococcal meningitis" ], [ "azathioprine", "cryptococcal meningitis" ] ]

Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.

[ [ "gold", "Neurological side effects" ] ]

Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.

[ [ "fluphenazine decanoate", "extrapyramidal side effects" ] ]

Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.

[ [ "tacrolimus", "HUS" ], [ "tacrolimus", "ARF" ] ]

Acute bilateral phrenic neuropathy following treatment with adalimumab.

[ [ "adalimumab", "Acute bilateral phrenic neuropathy" ] ]

Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.

[ [ "imipenem", "seizure" ], [ "cilastatin", "convulsions" ], [ "cilastatin", "seizure" ], [ "imipenem", "convulsions" ] ]

Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.

[ [ "amiodarone", "Nonsustained polymorphous ventricular tachycardia" ] ]

Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

[ [ "nitrofurantoin", "Bronchiolitis obliterans organising pneumonia" ] ]

The disease predisposes to severe vincristine neurotoxicity.

[ [ "vincristine", "vincristine neurotoxicity" ] ]

After the first oral dose of propranolol, syncope developed together with atrioventricular block.

[ [ "propranolol", "syncope" ], [ "propranolol", "atrioventricular block" ] ]

Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.

[ [ "enoxaparin", "Thrombocytosis" ] ]

Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.

[ [ "Oxygen", "pulmonary toxicity" ], [ "bleomycin", "pulmonary toxicity" ] ]

CONCLUSION: Severe and sustained ocular hypertension may occur after intravitreal ranibizumab.

[ [ "ranibizumab", "sustained ocular hypertension" ] ]

We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.

[ [ "senna", "cholestatic hepatitis" ] ]

Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.

[ [ "vasopressin", "Myoglobinuria" ], [ "vasopressin", "acute renal failure" ] ]

Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.

[ [ "desmopressin", "hyponatremia" ], [ "desmopressin", "Seizure" ] ]

We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).

[ [ "minocycline", "autoimmune hepatitis" ] ]

Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.

[ [ "lansoprazole", "Pheripheral edema" ], [ "omeprazole", "Pheripheral edema" ], [ "pantoprazole", "Pheripheral edema" ] ]

We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).

[ [ "sodium phosphate", "hyperphosphatemia" ], [ "sodium biphosphate", "hyperphosphatemia" ] ]

The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.

[ [ "vigabatrin", "field defects" ] ]

A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.

[ [ "human growth hormone", "Creutzfeldt-Jakob disease" ] ]

Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.

[ [ "diphenhydramine", "cardiotoxicity" ] ]

Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.

[ [ "nortriptyline", "sinus tachycardia" ] ]

OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.

[ [ "INH", "neurotoxicity" ], [ "isoniazid", "neurotoxicity" ] ]

Bleomycin pneumonitis potentiated by oxygen administration.

[ [ "Bleomycin", "pneumonitis" ] ]

The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.

[ [ "cyclosporin", "cholelithiasis" ] ]

Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.

[ [ "Methysergide", "retroperitoneal fibrosis" ] ]

A small initial dose of prazosin ranging from 0.5 to 1 mg has been recommended to avoid the first-dose phenomenon characterized by a sudden and severe drop in blood pressure after the administration of the first dose of prazosin.

[ [ "prazosin", "severe drop in blood pressure" ] ]

Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.

[ [ "nitroglycerin", "Paradoxical pulmonary vasoconstriction" ] ]

Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine.

[ [ "venlafaxine", "Increased ocular pressure" ] ]

Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.

[ [ "ribavirin", "Celiac disease" ], [ "pegylated interferon", "Celiac disease" ] ]

It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.

[ [ "cytarabine", "PPE" ] ]

Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.

[ [ "alendronate sodium", "scleritis" ] ]

Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.

[ [ "Amiodarone hydrochloride", "diffuse pulmonary infiltrates" ], [ "Amiodarone hydrochloride", "dyspnea" ], [ "Amiodarone hydrochloride", "pulmonary toxicity" ], [ "Amiodarone hydrochloride", "cough" ] ]

We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.

[ [ "5-aminosalicylic acid", "pancytopenia" ], [ "Pentasa", "pancytopenia" ] ]

I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.

[ [ "sumatriptan", "cardiac arrest" ] ]

Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.

[ [ "heparin", "thrombocytopenia" ] ]

We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.

[ [ "insulin", "hypoalbuminaemia" ], [ "insulin", "hyperinsulinaemia" ], [ "insulin", "anti-natriuresis" ], [ "insulin", "increased vascular permeability" ], [ "insulin", "insulin insensitivity" ] ]