harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.	[ [ "methotrexate", "extraarticular side effect" ] ]
Zidovudine induced pure red cell aplasia: a case report.	[ [ "Zidovudine", "pure red cell aplasia" ] ]
RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.	[ [ "INH", "neurotoxicity" ] ]
We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.	[ [ "aprotinin", "systemic allergic reaction" ] ]
Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.	[ [ "Acyclovir", "neurotoxicity" ] ]
A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.	[ [ "furazolidone", "jaundice" ], [ "nifuroxime", "jaundice" ] ]
In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.	[ [ "8-methoxypsoralen", "intense burn" ] ]
Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.	[ [ "Cyanamide", "liver dysfunction" ] ]
In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.	[ [ "hydroxyurea", "AL" ] ]
CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.	[ [ "metformin", "lactic acidosis" ] ]
Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.	[ [ "IFN-beta-1b", "proteinuria" ], [ "IFN-beta-1b", "nephrotic syndrome" ] ]
Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.	[ [ "desmopressin", "hyponatremia" ] ]
Neurotoxicity of intrathecal methotrexate: MR imaging findings.	[ [ "methotrexate", "Neurotoxicity" ] ]
Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.	[ [ "interferon-alpha", "Progressive anemia" ], [ "interleukin-2", "Progressive anemia" ] ]
The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.	[ [ "VGB", "visual dysfunction" ] ]
RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.	[ [ "progestin", "squamous metaplasia" ] ]
Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.	[ [ "dapsone", "Fatal agranulocytosis" ] ]
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).	[ [ "phenytoin", "unilateral gingival hyperplasia" ], [ "PHT", "unilateral gingival hyperplasia" ] ]
Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.	[ [ "heparin", "HIT" ] ]
In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.	[ [ "MTX", "severe dermatologic toxicity" ], [ "MTX", "acute hypersensitivity reaction" ] ]
Syncope induced by propranolol in hypertrophic cardiomyopathy.	[ [ "propranolol", "Syncope" ] ]
We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.	[ [ "tamoxifen", "endometriosis" ] ]
Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.	[ [ "ceftriaxone", "elevated hepato-biliary enzymes" ], [ "ceftriaxone", "transient biliary stasis" ] ]
A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.	[ [ "phenobarbitone", "severe unilateral grand mal seizure" ], [ "VPA", "severe unilateral grand mal seizure" ], [ "2-propylpentanoic acid", "severe unilateral grand mal seizure" ], [ "valproate", "severe unilateral grand mal seizure" ] ]
The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.	[ [ "CCNU", "pulmonary fibrosis" ] ]
Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.	[ [ "MTX", "pneumonitis" ] ]
Gold-induced aplastic anemia.	[ [ "Gold", "aplastic anemia" ] ]
Fixed drug eruption of the scrotum due to methylphenidate.	[ [ "methylphenidate", "Fixed drug eruption of the scrotum" ] ]
In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.	[ [ "BTX-B", "parasympathetic dysfunction of the visual system" ] ]
The aim of our paper was to describe hepatotoxicity of sirolimus (SRL) in a kidney graft recipient.	[ [ "sirolimus", "hepatotoxicity" ] ]
Clofibrate-induced myopathy in patients with diabetes insipidus.	[ [ "Clofibrate", "myopathy" ] ]
These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.	[ [ "D-Pen", "bicytopenia" ] ]
Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.	[ [ "interferon", "\"cotton-wool\" spots" ], [ "interferon", "retinal hemorrhage" ], [ "interferon", "Retinal abnormalities" ] ]
A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.	[ [ "pentazocine", "gradual stiffness" ], [ "pentazocine", "weakness of the lower extremities" ] ]
In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.	[ [ "isosorbide dinitrate", "blood pressure decreased" ], [ "isosorbide dinitrate", "sudden decrease in pulse rate" ], [ "isosorbide dinitrate", "syncope" ] ]
Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.	[ [ "acetazolamide", "acute renal failure" ] ]
We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.	[ [ "cisplatin", "anaphylactoid reactions" ] ]
Nephrotic range pseudoproteinuria in a tolmetin-treated patient.	[ [ "tolmetin", "Nephrotic range pseudoproteinuria" ] ]
A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.	[ [ "colchicine", "proximal muscle weakness" ] ]
Acute psychosis associated with levetiracetam.	[ [ "levetiracetam", "Acute psychosis" ] ]
We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.	[ [ "IFN-alpha", "Graves' disease" ] ]
CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.	[ [ "Copaxone", "Crohn's disease" ] ]
Danazol induced thrombocytopenia.	[ [ "Danazol", "thrombocytopenia" ] ]
The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.	[ [ "losartan", "angioedema" ] ]
We report three cases of patients who developed leukopenia during olanzapine treatment.	[ [ "olanzapine", "leukopenia" ] ]
There have been only two reports of cimetidine-induced hepatitis.	[ [ "cimetidine", "hepatitis" ] ]
This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method.	[ [ "clonazepam", "behavioral exacerbation" ] ]
CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.	[ [ "fentanyl", "serotonin syndrome" ] ]
We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.	[ [ "13-cis-retinoic acid", "acne fulminans" ] ]
Therefore, amantadine was permanently discontinued and the cornea cleared again.	[ [ "amantadine", "cornea" ] ]
Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.	[ [ "fluoxetine", "akathisia" ] ]
When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.	[ [ "heparin", "thrombosis" ] ]
CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.	[ [ "ifosfamide", "neurotoxicity" ] ]
Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).	[ [ "Ziprasidone", "tardive dyskinesia" ], [ "Ziprasidone", "TD" ], [ "Ziprasidone", "extrapyramidal symptoms" ] ]
Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.	[ [ "prostaglandin", "pigmentation" ], [ "prostaglandin", "Increased lash length" ] ]
Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.	[ [ "Amphotericin B", "fever" ], [ "AmB", "malaise" ], [ "Amphotericin B", "anaemia" ], [ "AmB", "anaemia" ], [ "Amphotericin B", "malaise" ], [ "Amphotericin B", "renal impairment" ], [ "AmB", "hypokalaemia" ], [ "AmB", "renal impairment" ], [ "AmB", "fever" ], [ "Amphotericin B", "hypokalaemia" ] ]
We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).	[ [ "olanzapine", "severe akathisia" ] ]
Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.	[ [ "colchicine", "myopathy" ], [ "statin", "myopathy" ] ]
Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.	[ [ "ethambutol", "optic neuritis" ] ]
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.	[ [ "methotrexate", "brainstem herniation" ], [ "methotrexate", "fatal cerebral edema" ] ]
Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.	[ [ "methotrexate", "Anterior lumbosacral radiculopathy" ] ]
CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.	[ [ "risperidone", "psychiatric and physical manifestations" ] ]
Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.	[ [ "phenobarbital", "Gynecomastia" ], [ "fluoresone", "Gynecomastia" ], [ "phenytoin", "Gynecomastia" ] ]
We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.	[ [ "lenalidomide", "severe aplastic anemia" ], [ "lenalidomide", "AA" ] ]
The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.	[ [ "asparaginase", "antithrombin III deficiency" ] ]
A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.	[ [ "carbamazepine", "right bundle branch block" ] ]
After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.	[ [ "pantoprazole", "general malaise" ] ]
Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.	[ [ "rituximab", "alveolar hemorrhage" ], [ "rituximab", "Interstitial pneumonitis" ] ]
The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.	[ [ "mefloquine", "cardiac arrests" ], [ "Halfan", "cardiac arrests" ], [ "mefloquine", "deaths" ], [ "Halfan", "deaths" ] ]
Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.	[ [ "procainamide", "Glomerulonephritis" ], [ "procainamide", "lupus erythematosus" ] ]
CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.	[ [ "IVTA", "ASPPC" ] ]
Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.	[ [ "sirolimus", "hypertension" ], [ "sirolimus", "hyperlipidemia" ], [ "Rapamycin", "hyperlipidemia" ], [ "SR", "myelosuppression" ], [ "Rapamycin", "hypertension" ], [ "SR", "infection" ], [ "SR", "hypertension" ], [ "Rapammune", "infection" ], [ "Rapamycin", "myelosuppression" ], [ "Rapammune", "hypertension" ], [ "sirolimus", "infection" ], [ "Rapammune", "hyperlipidemia" ], [ "Rapamycin", "infection" ], [ "Rapammune", "myelosuppression" ], [ "SR", "hyperlipidemia" ], [ "sirolimus", "myelosuppression" ] ]
Warfarin-associated thoracic aortic dissection in an elderly woman.	[ [ "Warfarin", "thoracic aortic dissection" ] ]
Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.	[ [ "topiramate", "angle-closure glaucoma" ], [ "methylprednisolone", "angle-closure glaucoma" ], [ "mannitol", "angle-closure glaucoma" ] ]
We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.	[ [ "methotrexate", "cytotoxic edema" ] ]
CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.	[ [ "Cefazolin", "leukopenia" ] ]
Interferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion.	[ [ "Interferon", "psychosis" ] ]
Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.	[ [ "ramipril", "cutaneous vasculitis" ] ]
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.	[ [ "dofetilide", "Marked QT prolongation" ], [ "dofetilide", "acute ischemia" ], [ "dofetilide", "torsades de pointes" ] ]
Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.	[ [ "cimetidine", "upper gastrointestinal bleeding" ], [ "tolazoline", "upper gastrointestinal bleeding" ] ]
Tacrolimus (FK506)-induced mutism after liver transplant.	[ [ "FK506", "mutism" ], [ "Tacrolimus", "mutism" ] ]
All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.	[ [ "phenytoin", "skin lesions" ] ]
We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.	[ [ "SPB", "increases in total Hb" ], [ "HU", "increases in total Hb" ] ]
BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.	[ [ "warfarin", "haemorrhagic side-effects" ] ]
Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.	[ [ "doxorubicin", "cardiomyopathy" ] ]
After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.	[ [ "nefazodone", "confusion" ], [ "nefazodone", "gray areas" ], [ "nefazodone", "headache" ] ]
We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.	[ [ "gemcitabine", "pericardial effusion" ] ]
We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.	[ [ "desipramine", "ejaculation without orgasm" ], [ "desipramine", "anhedonic ejaculation" ] ]
Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.	[ [ "amiodarone", "pneumonitis" ] ]
We report a case of RTA secondary to FK506 administration in liver transplantation.	[ [ "FK506", "RTA" ] ]
Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.	[ [ "cisplatin", "Clostridium difficile colitis" ] ]
This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.	[ [ "indomethacin", "hypoxia" ], [ "indomethacin", "ductal closure" ] ]
Pulmonary hypertension during lithium therapy: clinical case study.	[ [ "lithium", "Pulmonary hypertension" ] ]
This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.	[ [ "methazolamide", "agranulocytosis" ], [ "methazolamide", "aplastic anemia" ] ]
This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.	[ [ "risperidone", "neuroleptic malignant syndrome" ] ]
The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.	[ [ "sulfonamides", "erythema multiforme" ], [ "sulfonamides", "Stevens-Johnson syndrome" ] ]
A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).	[ [ "isosorbide dinitrate", "syncope" ] ]
Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.	[ [ "MTX", "renal toxicity" ] ]
From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.	[ [ "d-penicillamine", "acute generalized dystonia" ], [ "d-penicillamine", "brainstem and thalamic lesions" ] ]
A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.	[ [ "aspirin", "intracranial bleeding" ], [ "clopidogrel", "intracranial bleeding" ] ]

Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.

[ [ "methotrexate", "extraarticular side effect" ] ]

Zidovudine induced pure red cell aplasia: a case report.

[ [ "Zidovudine", "pure red cell aplasia" ] ]

RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.

[ [ "INH", "neurotoxicity" ] ]

We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.

[ [ "aprotinin", "systemic allergic reaction" ] ]

Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.

[ [ "Acyclovir", "neurotoxicity" ] ]

A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.

[ [ "furazolidone", "jaundice" ], [ "nifuroxime", "jaundice" ] ]

In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.

[ [ "8-methoxypsoralen", "intense burn" ] ]

Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.

[ [ "Cyanamide", "liver dysfunction" ] ]

In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.

[ [ "hydroxyurea", "AL" ] ]

CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.

[ [ "metformin", "lactic acidosis" ] ]

Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.

[ [ "IFN-beta-1b", "proteinuria" ], [ "IFN-beta-1b", "nephrotic syndrome" ] ]

Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.

[ [ "desmopressin", "hyponatremia" ] ]

Neurotoxicity of intrathecal methotrexate: MR imaging findings.

[ [ "methotrexate", "Neurotoxicity" ] ]

Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.

[ [ "interferon-alpha", "Progressive anemia" ], [ "interleukin-2", "Progressive anemia" ] ]

The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.

[ [ "VGB", "visual dysfunction" ] ]

RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.

[ [ "progestin", "squamous metaplasia" ] ]

Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.

[ [ "dapsone", "Fatal agranulocytosis" ] ]

INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).

[ [ "phenytoin", "unilateral gingival hyperplasia" ], [ "PHT", "unilateral gingival hyperplasia" ] ]

Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.

[ [ "heparin", "HIT" ] ]

In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.

[ [ "MTX", "severe dermatologic toxicity" ], [ "MTX", "acute hypersensitivity reaction" ] ]

Syncope induced by propranolol in hypertrophic cardiomyopathy.

[ [ "propranolol", "Syncope" ] ]

We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.

[ [ "tamoxifen", "endometriosis" ] ]

Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.

[ [ "ceftriaxone", "elevated hepato-biliary enzymes" ], [ "ceftriaxone", "transient biliary stasis" ] ]

A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.

[ [ "phenobarbitone", "severe unilateral grand mal seizure" ], [ "VPA", "severe unilateral grand mal seizure" ], [ "2-propylpentanoic acid", "severe unilateral grand mal seizure" ], [ "valproate", "severe unilateral grand mal seizure" ] ]

The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.

[ [ "CCNU", "pulmonary fibrosis" ] ]

Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.

[ [ "MTX", "pneumonitis" ] ]

Gold-induced aplastic anemia.

[ [ "Gold", "aplastic anemia" ] ]

Fixed drug eruption of the scrotum due to methylphenidate.

[ [ "methylphenidate", "Fixed drug eruption of the scrotum" ] ]

In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.

[ [ "BTX-B", "parasympathetic dysfunction of the visual system" ] ]

The aim of our paper was to describe hepatotoxicity of sirolimus (SRL) in a kidney graft recipient.

[ [ "sirolimus", "hepatotoxicity" ] ]

Clofibrate-induced myopathy in patients with diabetes insipidus.

[ [ "Clofibrate", "myopathy" ] ]

These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.

[ [ "D-Pen", "bicytopenia" ] ]

Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.

[ [ "interferon", "\"cotton-wool\" spots" ], [ "interferon", "retinal hemorrhage" ], [ "interferon", "Retinal abnormalities" ] ]

A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.

[ [ "pentazocine", "gradual stiffness" ], [ "pentazocine", "weakness of the lower extremities" ] ]

In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.

[ [ "isosorbide dinitrate", "blood pressure decreased" ], [ "isosorbide dinitrate", "sudden decrease in pulse rate" ], [ "isosorbide dinitrate", "syncope" ] ]

Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.

[ [ "acetazolamide", "acute renal failure" ] ]

We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.

[ [ "cisplatin", "anaphylactoid reactions" ] ]

Nephrotic range pseudoproteinuria in a tolmetin-treated patient.

[ [ "tolmetin", "Nephrotic range pseudoproteinuria" ] ]

A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.

[ [ "colchicine", "proximal muscle weakness" ] ]

Acute psychosis associated with levetiracetam.

[ [ "levetiracetam", "Acute psychosis" ] ]

We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.

[ [ "IFN-alpha", "Graves' disease" ] ]

CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.

[ [ "Copaxone", "Crohn's disease" ] ]

Danazol induced thrombocytopenia.

[ [ "Danazol", "thrombocytopenia" ] ]

The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.

[ [ "losartan", "angioedema" ] ]

We report three cases of patients who developed leukopenia during olanzapine treatment.

[ [ "olanzapine", "leukopenia" ] ]

There have been only two reports of cimetidine-induced hepatitis.

[ [ "cimetidine", "hepatitis" ] ]

This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method.

[ [ "clonazepam", "behavioral exacerbation" ] ]

CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.

[ [ "fentanyl", "serotonin syndrome" ] ]

We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.

[ [ "13-cis-retinoic acid", "acne fulminans" ] ]

Therefore, amantadine was permanently discontinued and the cornea cleared again.

[ [ "amantadine", "cornea" ] ]

Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.

[ [ "fluoxetine", "akathisia" ] ]

When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.

[ [ "heparin", "thrombosis" ] ]

CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.

[ [ "ifosfamide", "neurotoxicity" ] ]

Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).

[ [ "Ziprasidone", "tardive dyskinesia" ], [ "Ziprasidone", "TD" ], [ "Ziprasidone", "extrapyramidal symptoms" ] ]

Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.

[ [ "prostaglandin", "pigmentation" ], [ "prostaglandin", "Increased lash length" ] ]

Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.

[ [ "Amphotericin B", "fever" ], [ "AmB", "malaise" ], [ "Amphotericin B", "anaemia" ], [ "AmB", "anaemia" ], [ "Amphotericin B", "malaise" ], [ "Amphotericin B", "renal impairment" ], [ "AmB", "hypokalaemia" ], [ "AmB", "renal impairment" ], [ "AmB", "fever" ], [ "Amphotericin B", "hypokalaemia" ] ]

We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).

[ [ "olanzapine", "severe akathisia" ] ]

Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.

[ [ "colchicine", "myopathy" ], [ "statin", "myopathy" ] ]

Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.

[ [ "ethambutol", "optic neuritis" ] ]

A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.

[ [ "methotrexate", "brainstem herniation" ], [ "methotrexate", "fatal cerebral edema" ] ]

Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.

[ [ "methotrexate", "Anterior lumbosacral radiculopathy" ] ]

CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.

[ [ "risperidone", "psychiatric and physical manifestations" ] ]

Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.

[ [ "phenobarbital", "Gynecomastia" ], [ "fluoresone", "Gynecomastia" ], [ "phenytoin", "Gynecomastia" ] ]

We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.

[ [ "lenalidomide", "severe aplastic anemia" ], [ "lenalidomide", "AA" ] ]

The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.

[ [ "asparaginase", "antithrombin III deficiency" ] ]

A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.

[ [ "carbamazepine", "right bundle branch block" ] ]

After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.

[ [ "pantoprazole", "general malaise" ] ]

Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.

[ [ "rituximab", "alveolar hemorrhage" ], [ "rituximab", "Interstitial pneumonitis" ] ]

The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.

[ [ "mefloquine", "cardiac arrests" ], [ "Halfan", "cardiac arrests" ], [ "mefloquine", "deaths" ], [ "Halfan", "deaths" ] ]

Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.

[ [ "procainamide", "Glomerulonephritis" ], [ "procainamide", "lupus erythematosus" ] ]

CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.

[ [ "IVTA", "ASPPC" ] ]

Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.

[ [ "sirolimus", "hypertension" ], [ "sirolimus", "hyperlipidemia" ], [ "Rapamycin", "hyperlipidemia" ], [ "SR", "myelosuppression" ], [ "Rapamycin", "hypertension" ], [ "SR", "infection" ], [ "SR", "hypertension" ], [ "Rapammune", "infection" ], [ "Rapamycin", "myelosuppression" ], [ "Rapammune", "hypertension" ], [ "sirolimus", "infection" ], [ "Rapammune", "hyperlipidemia" ], [ "Rapamycin", "infection" ], [ "Rapammune", "myelosuppression" ], [ "SR", "hyperlipidemia" ], [ "sirolimus", "myelosuppression" ] ]

Warfarin-associated thoracic aortic dissection in an elderly woman.

[ [ "Warfarin", "thoracic aortic dissection" ] ]

Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.

[ [ "topiramate", "angle-closure glaucoma" ], [ "methylprednisolone", "angle-closure glaucoma" ], [ "mannitol", "angle-closure glaucoma" ] ]

We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.

[ [ "methotrexate", "cytotoxic edema" ] ]

CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.

[ [ "Cefazolin", "leukopenia" ] ]

Interferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion.

[ [ "Interferon", "psychosis" ] ]

Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.

[ [ "ramipril", "cutaneous vasculitis" ] ]

Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.

[ [ "dofetilide", "Marked QT prolongation" ], [ "dofetilide", "acute ischemia" ], [ "dofetilide", "torsades de pointes" ] ]

Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.

[ [ "cimetidine", "upper gastrointestinal bleeding" ], [ "tolazoline", "upper gastrointestinal bleeding" ] ]

Tacrolimus (FK506)-induced mutism after liver transplant.

[ [ "FK506", "mutism" ], [ "Tacrolimus", "mutism" ] ]

All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.

[ [ "phenytoin", "skin lesions" ] ]

We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.

[ [ "SPB", "increases in total Hb" ], [ "HU", "increases in total Hb" ] ]

BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.

[ [ "warfarin", "haemorrhagic side-effects" ] ]

Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.

[ [ "doxorubicin", "cardiomyopathy" ] ]

After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.

[ [ "nefazodone", "confusion" ], [ "nefazodone", "gray areas" ], [ "nefazodone", "headache" ] ]

We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.

[ [ "gemcitabine", "pericardial effusion" ] ]

We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.

[ [ "desipramine", "ejaculation without orgasm" ], [ "desipramine", "anhedonic ejaculation" ] ]

Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.

[ [ "amiodarone", "pneumonitis" ] ]

We report a case of RTA secondary to FK506 administration in liver transplantation.

[ [ "FK506", "RTA" ] ]

Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.

[ [ "cisplatin", "Clostridium difficile colitis" ] ]

This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.

[ [ "indomethacin", "hypoxia" ], [ "indomethacin", "ductal closure" ] ]

Pulmonary hypertension during lithium therapy: clinical case study.

[ [ "lithium", "Pulmonary hypertension" ] ]

This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.

[ [ "methazolamide", "agranulocytosis" ], [ "methazolamide", "aplastic anemia" ] ]

This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.

[ [ "risperidone", "neuroleptic malignant syndrome" ] ]

The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.

[ [ "sulfonamides", "erythema multiforme" ], [ "sulfonamides", "Stevens-Johnson syndrome" ] ]

A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).

[ [ "isosorbide dinitrate", "syncope" ] ]

Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.

[ [ "MTX", "renal toxicity" ] ]

From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.

[ [ "d-penicillamine", "acute generalized dystonia" ], [ "d-penicillamine", "brainstem and thalamic lesions" ] ]

A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.

[ [ "aspirin", "intracranial bleeding" ], [ "clopidogrel", "intracranial bleeding" ] ]