harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.	[ [ "heparin", "Skin necrosis" ] ]
A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).	[ [ "quinidine", "AVT" ], [ "disopyramide", "AVT" ], [ "quinidine", "torsade de pointes" ], [ "quinidine", "atypical ventricular tachycardia" ], [ "amiodarone", "AVT" ], [ "amiodarone", "torsade de pointes" ], [ "disopyramide", "atypical ventricular tachycardia" ], [ "amiodarone", "atypical ventricular tachycardia" ], [ "disopyramide", "torsade de pointes" ] ]
A patient with severe cholestatic jaundice induced by captopril is presented.	[ [ "captopril", "severe cholestatic jaundice" ] ]
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.	[ [ "goserelin acetate", "flare-up" ], [ "goserelin acetate", "worsening pleuritis carcinomatosa" ], [ "goserelin acetate", "severe dyspnea" ] ]
After stopping indapamide, glucose tolerance impairing may be reversed.	[ [ "indapamide", "glucose tolerance impairing" ] ]
Intrathecal methotrexate-induced acute cerebellar syndrome.	[ [ "methotrexate", "acute cerebellar syndrome" ] ]
We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.	[ [ "metoclopramide", "parkinsonism" ] ]
Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.	[ [ "BCNU", "myocardial ischemia" ] ]
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.	[ [ "IFN", "thrombocytopenia" ], [ "IFN", "hypoalbuminemia" ], [ "IFN", "ocular side effects" ] ]
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.	[ [ "hydroxyurea", "multiple skin cancers" ], [ "hydroxyurea", "longitudinal melanonychia" ] ]
Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.	[ [ "pregabalin", "cortical negative myoclonus" ] ]
The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.	[ [ "propranolol", "grand mal seizure" ], [ "propranolol", "photosensitivity" ], [ "propranolol", "delirium" ] ]
Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.	[ [ "methotrexate", "anaphylaxis" ] ]
Amphotericin B nephrotoxicity in humans decreased by salt repletion.	[ [ "Amphotericin B", "nephrotoxicity" ] ]
Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.	[ [ "amiodarone", "hepatotoxicity" ], [ "amiodarone", "aggravation of arrhythmia" ], [ "amiodarone", "pulmonary toxicity" ], [ "amiodarone", "thyroid diseases" ] ]
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.	[ [ "irbesartan", "angio-oedema" ], [ "irbesartan", "hypotensive shock" ] ]
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.	[ [ "cytarabine", "cutaneous herpes zoster" ] ]
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.	[ [ "dorzolamide", "choroidal detachment" ] ]
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.	[ [ "lithium", "blindness" ], [ "lithium", "CPM" ] ]
The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).	[ [ "heparin", "thrombosis syndrome" ], [ "heparin", "thrombocytopenia" ] ]
Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.	[ [ "L-asparaginase", "Delayed pseudocyst of the pancreas" ] ]
Captopril-induced acute reversible renal failure.	[ [ "Captopril", "acute reversible renal failure" ] ]
Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.	[ [ "Sulindac", "neurologic toxic effects" ], [ "Clinoril", "neurologic toxic effects" ] ]
Acute leukopenia associated with silver sulfadiazine therapy.	[ [ "silver sulfadiazine", "Acute leukopenia" ] ]
Intranasal desmopressin-induced hyponatremia.	[ [ "desmopressin", "hyponatremia" ] ]
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.	[ [ "dextran", "renal failure" ] ]
Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.	[ [ "dipivefrin", "cicatricial entropion" ] ]
Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.	[ [ "dapsone", "Methemoglobinemia" ] ]
Isoniazid and ethambutol as a cause of optic neuropathy.	[ [ "Isoniazid", "optic neuropathy" ], [ "ethambutol", "optic neuropathy" ] ]
We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.	[ [ "pegylated interferon alpha-2a", "ARDS" ], [ "pegIFNalpha-2a", "ARDS" ], [ "ribavirin", "ARDS" ], [ "ribavirin", "adult respiratory distress syndrome" ], [ "pegylated interferon alpha-2a", "adult respiratory distress syndrome" ], [ "pegIFNalpha-2a", "adult respiratory distress syndrome" ] ]
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.	[ [ "insulin", "lipoatrophies" ] ]
Nephropathy caused by methicillin therapy for staphylococcal septicemia.	[ [ "methicillin", "Nephropathy" ] ]
PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.	[ [ "triamcinolone acetate", "glaucoma" ], [ "corticosteroid", "glaucoma" ] ]
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.	[ [ "carbamazepine", "hypersensitivity syndrome" ] ]
In these patients, long-acting octreotide may trigger serious hypoglycemia.	[ [ "octreotide", "serious hypoglycemia" ] ]
This is the first report of UFT-induced scleroderma-like reaction.	[ [ "UFT", "UFT-induced scleroderma-like reaction" ] ]
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.	[ [ "papaverine", "penile fibrosis" ], [ "phentolamine", "penile fibrosis" ] ]
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.	[ [ "ifosfamide", "nonconvulsive status epilepticus" ] ]
Phenolphthalein-induced toxic epidermal necrolysis.	[ [ "Phenolphthalein", "toxic epidermal necrolysis" ] ]
The ampicillin rash occurring in cases of infectious mononucleosis is well documented.	[ [ "ampicillin", "ampicillin rash" ] ]
We also describe a case of timolol-induced ocular pemphigoid.	[ [ "timolol", "ocular pemphigoid" ] ]
Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.	[ [ "LASIK", "Traumatic late flap dehiscence" ], [ "LASIK", "Enterobacter keratitis" ] ]
Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.	[ [ "cytarabine", "PPE" ] ]
After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.	[ [ "5-ASA", "polyneuropathy" ] ]
Additionally, danazol produces hepatocellular damage in approximately 10% of women.	[ [ "danazol", "hepatocellular damage" ] ]
There is no consensus on the treatment of ticlopidine-induced marrow aplasia.	[ [ "ticlopidine", "marrow aplasia" ] ]
Piloerection induced by replacing fluvoxamine with milnacipran.	[ [ "fluvoxamine", "Piloerection" ], [ "milnacipran", "Piloerection" ] ]
We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.	[ [ "ethambutol", "bilateral optic neuropathy" ] ]
We report a case of pediatric bupropion ingestion resulting in multiple seizures.	[ [ "bupropion", "multiple seizures" ] ]
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.	[ [ "ifosfamide", "Lethal anuria" ] ]
Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.	[ [ "hepatitis B vaccination", "Lichen planus" ] ]
Paraplegia following intrathecal cytosine arabinoside.	[ [ "cytosine arabinoside", "Paraplegia" ] ]
Primary central nervous system lymphoma in a patient treated with natalizumab.	[ [ "natalizumab", "Primary central nervous system lymphoma" ] ]
Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.	[ [ "MTX", "pulmonary toxicity" ], [ "MTX", "pneumonitis" ] ]
At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.	[ [ "sunitinib", "pain" ], [ "sunitinib", "development of abnormally large mammary glands" ], [ "sunitinib", "peri-areolar erythema" ] ]
A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.	[ [ "warfarin", "hematochezia" ] ]
Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.	[ [ "heparin", "thrombocytopenia" ], [ "heparin", "Massive pulmonary embolism" ] ]
Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.	[ [ "F VIII", "Portal vein thrombosis" ] ]
CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.	[ [ "LMWH", "Spontaneous hemothorax" ] ]
We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.	[ [ "fludarabine", "fatal intravascular autoimmune hemolytic anemia" ], [ "fludarabine", "AIHA" ] ]
Photo-onycholysis caused by olanzapine and aripiprazole.	[ [ "olanzapine", "Photo-onycholysis" ], [ "aripiprazole", "Photo-onycholysis" ] ]
Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.	[ [ "Zoledronic acid", "bronchospasm" ], [ "Zoledronic acid", "carpopedal spasm" ] ]
The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.	[ [ "TMP-Sx", "TEN" ], [ "TMP-Sx", "SJS" ] ]
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.	[ [ "lithium", "Nephrogenic diabetes insipidus" ], [ "lithium", "NDI" ] ]
Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.	[ [ "cyclophosphamide", "metastatic nodules" ], [ "Bleomycin", "metastatic nodules" ] ]
A new type of minocycline-induced cutaneous hyperpigmentation.	[ [ "minocycline", "cutaneous hyperpigmentation" ] ]
So far, few cases of pulmonary side effects caused by ticlopidine have been reported.	[ [ "ticlopidine", "pulmonary side effects" ] ]
As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.	[ [ "tuberculin", "hypersensitivity response" ] ]
The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.	[ [ "phenytoin", "soft-tissue injury" ], [ "phenytoin", "purple glove syndrome" ] ]
After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.	[ [ "pegvisomant", "hepatitis" ], [ "pegvisomant", "hepatic enzyme disturbances" ] ]
This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.	[ [ "methotrexate", "fatal encephalopathy" ], [ "methotrexate", "mild neurotoxicity" ] ]
Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.	[ [ "ribavirin", "sarcoidosis" ], [ "interferon alpha 2b", "sarcoidosis" ] ]
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.	[ [ "vancomycin", "Agranulocytosis" ] ]
Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.	[ [ "citalopram", "chest tightness" ], [ "citalopram", "dizziness" ] ]
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.	[ [ "IFN-alpha", "changes in serotonergic or noradrenergic neurotransmission" ] ]
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.	[ [ "oxcarbazepine", "severe rash" ] ]
Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.	[ [ "etanercept", "Reversible heart failure" ] ]
A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.	[ [ "digoxin", "complete atrioventricular block" ] ]
Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.	[ [ "cisplatin", "C. difficile colitis" ] ]
Metoclopramide-induced parkinsonism.	[ [ "Metoclopramide", "parkinsonism" ] ]
Acne provoked by gold seems not to have been described elsewhere.	[ [ "gold", "Acne" ] ]
A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.	[ [ "lamotrigine", "TEN" ] ]
Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.	[ [ "methylprednisolone", "seizures" ], [ "methylprednisolone", "transient blindness" ] ]
A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.	[ [ "metformin", "miliary tuberculosis" ] ]
Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.	[ [ "valproic acid", "altered mental status" ] ]
Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.	[ [ "raloxifene", "aggravation of nonalcoholic steatohepatitis" ] ]
Nitrendipine-induced gingival hyperplasia.	[ [ "Nitrendipine", "gingival hyperplasia" ] ]
OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.	[ [ "chloroquine", "severe chloroquine toxicity" ] ]
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.	[ [ "Methanol", "Methanol toxicity" ], [ "Methanol", "severe central nervous system insult" ], [ "Methanol", "bilateral putaminal injury" ] ]
This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.	[ [ "sulfasalazine", "hemophagocytic syndrome" ] ]
PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.	[ [ "bevacizumab", "acute endophthalmitis" ] ]
Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.	[ [ "phenytoin", "Erythema multiforme" ] ]
The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.	[ [ "alteplase", "diffuse subfascial hematoma" ], [ "alteplase", "cutaneous ecchymosis" ], [ "alteplase", "sudden fall in hemoglobin" ] ]
We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).	[ [ "Molipaxin", "GPP" ], [ "Molipaxin", "generalized pustular psoriasis" ], [ "trazodone hydrochloride", "GPP" ], [ "trazodone hydrochloride", "generalized pustular psoriasis" ] ]
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.	[ [ "perhexiline maleate", "hepatic dysfunction" ], [ "perhexiline maleate", "papilloedema" ] ]
Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.	[ [ "tacrolimus", "Reflex sympathetic dystrophy syndrome" ] ]
Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.	[ [ "Imidazoline", "Imidazoline intoxication" ] ]
Allergic contact dermatitis to compound tincture of benzoin.	[ [ "benzoin", "Allergic contact dermatitis" ] ]
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.	[ [ "cefuroxime", "renal deterioration" ] ]
Cephalosporin-induced leukopenia following rechallenge with cefoxitin.	[ [ "Cephalosporin", "leukopenia" ] ]

Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.

[ [ "heparin", "Skin necrosis" ] ]

A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).

[ [ "quinidine", "AVT" ], [ "disopyramide", "AVT" ], [ "quinidine", "torsade de pointes" ], [ "quinidine", "atypical ventricular tachycardia" ], [ "amiodarone", "AVT" ], [ "amiodarone", "torsade de pointes" ], [ "disopyramide", "atypical ventricular tachycardia" ], [ "amiodarone", "atypical ventricular tachycardia" ], [ "disopyramide", "torsade de pointes" ] ]

A patient with severe cholestatic jaundice induced by captopril is presented.

[ [ "captopril", "severe cholestatic jaundice" ] ]

Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.

[ [ "goserelin acetate", "flare-up" ], [ "goserelin acetate", "worsening pleuritis carcinomatosa" ], [ "goserelin acetate", "severe dyspnea" ] ]

After stopping indapamide, glucose tolerance impairing may be reversed.

[ [ "indapamide", "glucose tolerance impairing" ] ]

Intrathecal methotrexate-induced acute cerebellar syndrome.

[ [ "methotrexate", "acute cerebellar syndrome" ] ]

We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.

[ [ "metoclopramide", "parkinsonism" ] ]

Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.

[ [ "BCNU", "myocardial ischemia" ] ]

Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.

[ [ "IFN", "thrombocytopenia" ], [ "IFN", "hypoalbuminemia" ], [ "IFN", "ocular side effects" ] ]

Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.

[ [ "hydroxyurea", "multiple skin cancers" ], [ "hydroxyurea", "longitudinal melanonychia" ] ]

Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.

[ [ "pregabalin", "cortical negative myoclonus" ] ]

The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.

[ [ "propranolol", "grand mal seizure" ], [ "propranolol", "photosensitivity" ], [ "propranolol", "delirium" ] ]

Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.

[ [ "methotrexate", "anaphylaxis" ] ]

Amphotericin B nephrotoxicity in humans decreased by salt repletion.

[ [ "Amphotericin B", "nephrotoxicity" ] ]

Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.

[ [ "amiodarone", "hepatotoxicity" ], [ "amiodarone", "aggravation of arrhythmia" ], [ "amiodarone", "pulmonary toxicity" ], [ "amiodarone", "thyroid diseases" ] ]

A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.

[ [ "irbesartan", "angio-oedema" ], [ "irbesartan", "hypotensive shock" ] ]

In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.

[ [ "cytarabine", "cutaneous herpes zoster" ] ]

We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.

[ [ "dorzolamide", "choroidal detachment" ] ]

After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.

[ [ "lithium", "blindness" ], [ "lithium", "CPM" ] ]

The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).

[ [ "heparin", "thrombosis syndrome" ], [ "heparin", "thrombocytopenia" ] ]

Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.

[ [ "L-asparaginase", "Delayed pseudocyst of the pancreas" ] ]

Captopril-induced acute reversible renal failure.

[ [ "Captopril", "acute reversible renal failure" ] ]

Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.

[ [ "Sulindac", "neurologic toxic effects" ], [ "Clinoril", "neurologic toxic effects" ] ]

Acute leukopenia associated with silver sulfadiazine therapy.

[ [ "silver sulfadiazine", "Acute leukopenia" ] ]

Intranasal desmopressin-induced hyponatremia.

[ [ "desmopressin", "hyponatremia" ] ]

While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.

[ [ "dextran", "renal failure" ] ]

Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.

[ [ "dipivefrin", "cicatricial entropion" ] ]

Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.

[ [ "dapsone", "Methemoglobinemia" ] ]

Isoniazid and ethambutol as a cause of optic neuropathy.

[ [ "Isoniazid", "optic neuropathy" ], [ "ethambutol", "optic neuropathy" ] ]

We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.

[ [ "pegylated interferon alpha-2a", "ARDS" ], [ "pegIFNalpha-2a", "ARDS" ], [ "ribavirin", "ARDS" ], [ "ribavirin", "adult respiratory distress syndrome" ], [ "pegylated interferon alpha-2a", "adult respiratory distress syndrome" ], [ "pegIFNalpha-2a", "adult respiratory distress syndrome" ] ]

OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.

[ [ "insulin", "lipoatrophies" ] ]

Nephropathy caused by methicillin therapy for staphylococcal septicemia.

[ [ "methicillin", "Nephropathy" ] ]

PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.

[ [ "triamcinolone acetate", "glaucoma" ], [ "corticosteroid", "glaucoma" ] ]

Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.

[ [ "carbamazepine", "hypersensitivity syndrome" ] ]

In these patients, long-acting octreotide may trigger serious hypoglycemia.

[ [ "octreotide", "serious hypoglycemia" ] ]

This is the first report of UFT-induced scleroderma-like reaction.

[ [ "UFT", "UFT-induced scleroderma-like reaction" ] ]

We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.

[ [ "papaverine", "penile fibrosis" ], [ "phentolamine", "penile fibrosis" ] ]

CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.

[ [ "ifosfamide", "nonconvulsive status epilepticus" ] ]

Phenolphthalein-induced toxic epidermal necrolysis.

[ [ "Phenolphthalein", "toxic epidermal necrolysis" ] ]

The ampicillin rash occurring in cases of infectious mononucleosis is well documented.

[ [ "ampicillin", "ampicillin rash" ] ]

We also describe a case of timolol-induced ocular pemphigoid.

[ [ "timolol", "ocular pemphigoid" ] ]

Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.

[ [ "LASIK", "Traumatic late flap dehiscence" ], [ "LASIK", "Enterobacter keratitis" ] ]

Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.

[ [ "cytarabine", "PPE" ] ]

After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.

[ [ "5-ASA", "polyneuropathy" ] ]

Additionally, danazol produces hepatocellular damage in approximately 10% of women.

[ [ "danazol", "hepatocellular damage" ] ]

There is no consensus on the treatment of ticlopidine-induced marrow aplasia.

[ [ "ticlopidine", "marrow aplasia" ] ]

Piloerection induced by replacing fluvoxamine with milnacipran.

[ [ "fluvoxamine", "Piloerection" ], [ "milnacipran", "Piloerection" ] ]

We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.

[ [ "ethambutol", "bilateral optic neuropathy" ] ]

We report a case of pediatric bupropion ingestion resulting in multiple seizures.

[ [ "bupropion", "multiple seizures" ] ]

Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.

[ [ "ifosfamide", "Lethal anuria" ] ]

Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.

[ [ "hepatitis B vaccination", "Lichen planus" ] ]

Paraplegia following intrathecal cytosine arabinoside.

[ [ "cytosine arabinoside", "Paraplegia" ] ]

Primary central nervous system lymphoma in a patient treated with natalizumab.

[ [ "natalizumab", "Primary central nervous system lymphoma" ] ]

Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.

[ [ "MTX", "pulmonary toxicity" ], [ "MTX", "pneumonitis" ] ]

At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.

[ [ "sunitinib", "pain" ], [ "sunitinib", "development of abnormally large mammary glands" ], [ "sunitinib", "peri-areolar erythema" ] ]

A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.

[ [ "warfarin", "hematochezia" ] ]

Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.

[ [ "heparin", "thrombocytopenia" ], [ "heparin", "Massive pulmonary embolism" ] ]

Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.

[ [ "F VIII", "Portal vein thrombosis" ] ]

CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.

[ [ "LMWH", "Spontaneous hemothorax" ] ]

We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.

[ [ "fludarabine", "fatal intravascular autoimmune hemolytic anemia" ], [ "fludarabine", "AIHA" ] ]

Photo-onycholysis caused by olanzapine and aripiprazole.

[ [ "olanzapine", "Photo-onycholysis" ], [ "aripiprazole", "Photo-onycholysis" ] ]

Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.

[ [ "Zoledronic acid", "bronchospasm" ], [ "Zoledronic acid", "carpopedal spasm" ] ]

The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.

[ [ "TMP-Sx", "TEN" ], [ "TMP-Sx", "SJS" ] ]

Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.

[ [ "lithium", "Nephrogenic diabetes insipidus" ], [ "lithium", "NDI" ] ]

Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.

[ [ "cyclophosphamide", "metastatic nodules" ], [ "Bleomycin", "metastatic nodules" ] ]

A new type of minocycline-induced cutaneous hyperpigmentation.

[ [ "minocycline", "cutaneous hyperpigmentation" ] ]

So far, few cases of pulmonary side effects caused by ticlopidine have been reported.

[ [ "ticlopidine", "pulmonary side effects" ] ]

As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.

[ [ "tuberculin", "hypersensitivity response" ] ]

The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.

[ [ "phenytoin", "soft-tissue injury" ], [ "phenytoin", "purple glove syndrome" ] ]

After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.

[ [ "pegvisomant", "hepatitis" ], [ "pegvisomant", "hepatic enzyme disturbances" ] ]

This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.

[ [ "methotrexate", "fatal encephalopathy" ], [ "methotrexate", "mild neurotoxicity" ] ]

Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.

[ [ "ribavirin", "sarcoidosis" ], [ "interferon alpha 2b", "sarcoidosis" ] ]

Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.

[ [ "vancomycin", "Agranulocytosis" ] ]

Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.

[ [ "citalopram", "chest tightness" ], [ "citalopram", "dizziness" ] ]

While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.

[ [ "IFN-alpha", "changes in serotonergic or noradrenergic neurotransmission" ] ]

This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.

[ [ "oxcarbazepine", "severe rash" ] ]

Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.

[ [ "etanercept", "Reversible heart failure" ] ]

A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.

[ [ "digoxin", "complete atrioventricular block" ] ]

Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.

[ [ "cisplatin", "C. difficile colitis" ] ]

Metoclopramide-induced parkinsonism.

[ [ "Metoclopramide", "parkinsonism" ] ]

Acne provoked by gold seems not to have been described elsewhere.

[ [ "gold", "Acne" ] ]

A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.

[ [ "lamotrigine", "TEN" ] ]

Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.

[ [ "methylprednisolone", "seizures" ], [ "methylprednisolone", "transient blindness" ] ]

A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.

[ [ "metformin", "miliary tuberculosis" ] ]

Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.

[ [ "valproic acid", "altered mental status" ] ]

Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.

[ [ "raloxifene", "aggravation of nonalcoholic steatohepatitis" ] ]

Nitrendipine-induced gingival hyperplasia.

[ [ "Nitrendipine", "gingival hyperplasia" ] ]

OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.

[ [ "chloroquine", "severe chloroquine toxicity" ] ]

Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.

[ [ "Methanol", "Methanol toxicity" ], [ "Methanol", "severe central nervous system insult" ], [ "Methanol", "bilateral putaminal injury" ] ]

This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.

[ [ "sulfasalazine", "hemophagocytic syndrome" ] ]

PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.

[ [ "bevacizumab", "acute endophthalmitis" ] ]

Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.

[ [ "phenytoin", "Erythema multiforme" ] ]

The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.

[ [ "alteplase", "diffuse subfascial hematoma" ], [ "alteplase", "cutaneous ecchymosis" ], [ "alteplase", "sudden fall in hemoglobin" ] ]

We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).

[ [ "Molipaxin", "GPP" ], [ "Molipaxin", "generalized pustular psoriasis" ], [ "trazodone hydrochloride", "GPP" ], [ "trazodone hydrochloride", "generalized pustular psoriasis" ] ]

A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.

[ [ "perhexiline maleate", "hepatic dysfunction" ], [ "perhexiline maleate", "papilloedema" ] ]

Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.

[ [ "tacrolimus", "Reflex sympathetic dystrophy syndrome" ] ]

Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.

[ [ "Imidazoline", "Imidazoline intoxication" ] ]

Allergic contact dermatitis to compound tincture of benzoin.

[ [ "benzoin", "Allergic contact dermatitis" ] ]

The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.

[ [ "cefuroxime", "renal deterioration" ] ]

Cephalosporin-induced leukopenia following rechallenge with cefoxitin.

[ [ "Cephalosporin", "leukopenia" ] ]