id stringlengths 1 4 | translation dict |
|---|---|
1200 | {
"en": "This data has the potential to help the discovery of gene targets for new antibiotics and tackle bacterial resistance.",
"fr": "Ce système a le potentiel d'aider à la découverte de gènes cibles pour le développement de nouveaux antibiotiques, et de répondre à la résistance croissante des bactéries."
} |
1201 | {
"en": "We collected and compared intestinal microbiota and microbiomes from several Podarcis sicula lizards, which live in Croatian continental and insular populations.",
"fr": "Nous avons collecté et comparé les microbiotes et les microbiomes intestinaux de plusieurs dizaines de lézards de l'espèce Podarcis sicu... |
1202 | {
"en": "The database also includes several molecular markers such as MIRU-VNTRs (mycobacterial interspersed repetitive units- variable number of tandem repeats) and Spoligotype43 allowing a better description and identification of the families of genotypic profiles of Mycobacterium tuberculosis complex.",
"fr": "C... |
1203 | {
"en": "The main objectives of this thesis were (i) to search for the selection pressure exerted on plant orthologous genes and (ii) to describe the structural and functional features they share in particular in their promoters, in order to (iii) define a novel phylogenetic footprinting approach.",
"fr": "Les obje... |
1204 | {
"en": "Following the example of regular expressions, the Automata theory offer tools to define a recognition principle for the different properties of this patterns.",
"fr": "Comme pour les expressions régulières, la théorie des automates offre des formalismes de reconnaissance pour les différents types de propri... |
1205 | {
"en": "Hence TP53INP family is involved in at least two major cellular functions, apoptosis and autophagy.",
"fr": "Ainsi, la famille TP53INP est impliquée dans les fonctions cellulaires majeures que sont l'apoptose et l'autophagie."
} |
1206 | {
"en": "Currently, there is no efficient method to control the pathogen.",
"fr": "Aujourd'hui, aucune méthode de lutte ne parvient à lutter efficacement contre la pathogène."
} |
1207 | {
"en": "The objective is to underline the importance of the choice of iteration mode for the dynamics of these networks especially for the observed limit cycles.",
"fr": "L'objectif est de mettre en évidence l'importance du choix du mode d'itération pour la dynamique de ces réseaux, et en particulier pour les cycl... |
1208 | {
"en": "These approaches consistin identifying a biologically significant structure in D, whose vertices induce in G a structure that is alsobiologically significant.",
"fr": "Ces approches consistent à identifier unestructure biologiquement significative dans D, dont les sommets induisent dans G une structure qui... |
1209 | {
"en": "In the last part, we will model the proteins, peptides and glycoproteins degradation potential at a microbial community scale, by completing an existing model created by two INRA teams using a Non-negative Matrix factorisation approach. This approach is built on a priori information and knowledge about the m... |
1210 | {
"en": "Assets and liabilities of this shift are discussed, while the role of voucher specimens is reiterated and, for observations, the need for ancillary data is underlined.",
"fr": "Les dangers et avantages liés à ce changement de pratique sont discutés, le rôle de spécimens vouchers est rappelé et la nécessité... |
1211 | {
"en": "Durandal exploits the propagation of geometric constraints to accelerate the exact clustering algorithm for protein models.",
"fr": "Durandal exploite la propagation de contraintes géométriques afin d'accélérer l'algorithme de partitionnement exact pour des modèles de protéines."
} |
1212 | {
"en": "), and represent vast morphological and genetic diversity. Not surprisingly given their numerical dominance, viruses significantly impact ecosystems through regulating microbial populations, driving major biogeochemical cycles, and shaping the evolution of hosts genomes. However, our understanding of viruses... |
1213 | {
"en": "Genomic medicine is often presented as a new paradigm for personalized healthcare.",
"fr": "La médecine génomique est souvent présentée comme un nouveau paradigme permettant une prise en charge personnalisée du patient."
} |
1214 | {
"en": "Where are the ecological niches?",
"fr": "Où sont les niches écologiques ?"
} |
1215 | {
"en": "First, there is no consensus on the most reliable bioinformatics approach to determine the identity and abundance of microorganisms present in plant samples.",
"fr": "Tout d'abord, il n'existe pas de consensus concernant l'approche bioinformatique la plus fiable pour déterminer l'identité et l'abondance de... |
1216 | {
"en": "The last contribution of this thesis is related to the development of GEPeTTO, a prototype of the prioritization of genes.",
"fr": "Enfin, l'ultime contribution de cette thèse est liée au développement de GEPeTTO, un prototype de priorisation de gènes. Une application biologique a été réalisée."
} |
1217 | {
"en": "Our results demonstrated that this induced local changes in origin efficiency near the endpoints of the rearranged region during both mitotic and pre-meiotic S phase.",
"fr": "Nos résultats ont montré que ces réarrangements induisaient des changements de l'efficacité des origines localisées spécifiquement ... |
1218 | {
"en": "In planta subcellular localization of a set of MiSSPs belonging to a core-regulon showed that three of them are able to target different plant subcellular compartments.",
"fr": "Un jeu de MiSSPs de L. bicolor ont été localisées in planta. Trois d'entre eux ciblent spécifiquement des compartiments subcellul... |
1219 | {
"en": "A theoretical version of this problem is the problem of the shortest superstring: given a set of words (own set of reads), we try to find the shortest string that contains all others as substring (the genome of origin).",
"fr": "Une version théorique de cette problématique est le problème de la plus courte... |
1220 | {
"en": "All techniques show that the presence of 5% DMSO does not significantly modify the affinity of ADA for gamma-CD, while the affinity is dramatically reduced for beta-CD.",
"fr": "Toutes les techniques ont montré que le DMSO n'a pas d'effet sur l'affinité de l'ADA pour la gamma-CD alors qu'il diminue forteme... |
1221 | {
"en": "The theoretical complexity of this problem has been studied and a practical algorithm to solve it is presented. The second part presents a formalization of a problem concerning graphs comparison.",
"fr": "La complexité de ce problème a été étudiée et un algorithme le résolvant est présenté. La seconde part... |
1222 | {
"en": "The study of informative families included in this research project on cranio-facial and oro-dental anomalies, by using genetic strategies such as candidate gene mutational analysis,homozygosity mapping and next generation sequencing, allowed the discovery of novel genes and mutations in AI.",
"fr": "L'étu... |
1223 | {
"en": "More than 200,000 campylobacteriosis cases are reported in the European Union each year.",
"fr": "Plus de 200 000 cas de campylobacterioses sont recensés dans l'Union Européenne chaque année, avec comme principale espèce Campylobacter jejuni."
} |
1224 | {
"en": "From divergent abdominal fat weight chicken lines, I lastly identified new lncRNAs that potentially regulate this lipid metabolism.",
"fr": "Enfin, à partir de lignées divergentes pour le poids de gras abdominal, j'ai également mis en évidence de nouveaux ARNlnc potentiellement régulateurs de ce métabolism... |
1225 | {
"en": "All kinds of species interactions such as mutualism, commensalism, and competition, are omnipresent in nature and occur often at the metabolic level.",
"fr": "Tous les types d'interactions entre espèces tels que le mutualisme, le commensalisme, et la compétition, sont omniprésents dans la nature et impliqu... |
1226 | {
"en": "Horizontal transfers are events that allow the exchange of genetic material between two species, without reproduction.",
"fr": "Les transferts horizontaux sont définis par la transmission de matériel génétique entre deux espèces, sans reproduction sexuée."
} |
1227 | {
"en": "Modulation of chromatin structure via histone modification is a major epigenetic mechanism and key regulator of gene expression, however, the contribution of chromatin heterogeneity to tumor evolution remains unknown, mostly due to the lack of methods to study it in tumors.",
"fr": "La modulation de la str... |
1228 | {
"en": "Given the clinical and genetic overlap of EOS with other neurodevelopmental disorders, including Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), we paid particular attention to the genes involved in neurodevelopment.",
"fr": "Compte tenu du chevauchement clinique et géné... |
1229 | {
"en": "We will evaluate methods for reprogramming TME to bypass immunosuppression and improve the efficacy of cancer immunotherapy in patient-derived xenograft mice.",
"fr": "Nous évaluerons également des méthodes de reprogrammation des TME pour contourner l'immunosuppression et améliorer l'efficacité de l'immuno... |
1230 | {
"en": "For instance, ambient occlusion or sphere raycasting with dynamic shadows can augment a physical object taking the real illumination of the scene for a better insertion in an Augmented Reality context.",
"fr": "Par exemple, l'occultation ambiante ou le raycasting de sphères avec des ombres portées dynamiqu... |
1231 | {
"en": "The structure, inhibition, and evolution of these two systems were studied by combining sequence analysis and molecular modeling methods.",
"fr": "La structure, l'inhibition et l'évolution de ces deux systèmes ont été étudiées en combinant des méthodes d'analyse de séquences et de modélisation moléculaire.... |
1232 | {
"en": "Taken together, these exploratory studies allow a more reasoned choice of methodology for the study of plant-associated viromes and expand our knowledge of plant virus diversity especially in neglected wild plant populations, providing important references for the further viral ecology and evolution studies.... |
1233 | {
"en": "Then, they were applied to The Cancer Genome Atlas datasets in order to identify genes with a differential expression variance when comparing normal and tumor samples.",
"fr": "Par la suite, elles ont été appliquées aux jeux de données The Cancer Genome Atlas dans le but d'identifier des gènes ayant une di... |
1234 | {
"en": "We reproduced and further extended our observations using subcutaneous injection of CT26 colorectal cancer cells in syngeneic immunocompetent BALB/c mice and B16 melanoma in C57BL/6 mice.",
"fr": "Nous avons reproduit et étendu nos observations en utilisant des lignées modèles de cancéreuses colorectaux (C... |
1235 | {
"en": "These transcripts are responsible for the regulatory mechanisms of the organism, some of them are translated into protein.",
"fr": "Ces transcrits sont responsables des mécanismes de régulation de l'organisme, certains sont traduits en protéine."
} |
1236 | {
"en": "Some authors have thus distinguished between genes 'essential for survival' and 'essential for fitness'.",
"fr": "Certains auteurs ont ainsi fait la distinction entre des gènes 'essentiels pour la survie' et des gènes 'essentiels pour la fitness'."
} |
1237 | {
"en": "Other particular traits were explored, such as the reversible obesity of the grey mouse lemur or the interactions between sociality and longevity in the ant.",
"fr": "D'autres traits particuliers ont été explorés, tels que l'obésité réversible du microcèbe, ou encore les interactions entre socialité et lon... |
1238 | {
"en": "This resulted in the identification of 477 potential interacting partners, of which, 180 were determined to have a high probability of interacting directly with the kinase.",
"fr": "J'ai identifié 477 partenaires potentiels dont 180 présentant une forte probabilité d'être des partenaires directs de la kina... |
1239 | {
"en": "As more genomes are sequenced, the exact localisation of protein-coding genes in genomic DNA sequences is a major challenge in bioinformatics and modern biology.",
"fr": "L'exploitation des données issues des projets de séquençage des génomes représente un enjeu majeur de la biologie moderne et de la bioin... |
1240 | {
"en": "The first axis of this work will concern researching associations between certain TSPAN5 and ERICH3 variants found in two metabolomic and genetic studies (GWAS) analyzing plasma concentrations of kynurenine and serotonin.",
"fr": "Le premier axe concernera la recherche d'associations entre certains variant... |
1241 | {
"en": "During the first part of this project we constructed a bladder-cancer-specific gene regulatory network using a data mining algorithm (H-LICORN) as well as transcriptomic data coming from: (1) bladder cancer cell lines and bladder tumors expressing a mutated FGFR3 and (2) different preclinical models where th... |
1242 | {
"en": "The set of bounded n-compositions of an interval simultaneously generalizes product set and compositions of an integer, and so < puts under a single roof all theseGray codes.",
"fr": "L'ensemble des n compositions bornées d'un intervalle généralise simultanément l'ensemble produit et l'ensemble des composi... |
1243 | {
"en": "The characterization of their surface, chemical and colloidal stability as well as their cytotoxicity were studied in order to consider their use in biological environments.",
"fr": "La caractérisation de leur surface, leur stabilité chimique et colloïdale ainsi que leur cytotoxicité ont été étudiées afin ... |
1244 | {
"en": "For instance, the cells that are supposed to fight a disease can be silenced.",
"fr": "Par exemple, les cellules qui sont supposées combattre l'infection peuvent être rendues silencieuses."
} |
1245 | {
"en": "In this project we intend to perform a change of perspective as, in order to face the diversity and the heterogeneity of omic data and that of machine learning strategies, we intend to make profit from all these available pieces of evidence thanks to a consensus based approach.",
"fr": "Dans ce projet, nou... |
1246 | {
"en": "In order to provide information on the mechanisms of action and potential toxic effects of PhAC, data lacking in the literature, -omic approaches such as metabolomics and proteomics were applied.",
"fr": "Afin de renseigner les mécanismes d'action et les potentiels effets toxiques des PP, données manquante... |
1247 | {
"en": "The object of the simulation is the observation of the cell in a given state, and for a given process which implicates a cascade of genes; the examples of biological algorithms tested combines several types of regulation: the lactose operon, regulation of metallothionein, catabolism of galactose in yeast, th... |
1248 | {
"en": "In this project, we will implement state-of-the-art, multi-level omics approaches to identify how reactive glial cells can help neurons clear toxic mHtt.",
"fr": "Dans ce projet, nous utiliserons des approches \" multi-omics \" de pointe pour identifier comment les cellules gliales réactives aident les neu... |
1249 | {
"en": "This work highlights the utility of the zebrafish model organism as an informative experimental tool for variant interpretation in genomic medicine, especially in neurodevelopmental disorders.",
"fr": "Confirmant la haute valeur ajoutée du poisson zèbre pour modéliser les variations génétiques chez des pat... |
1250 | {
"en": "The parameters of these two models are conditional probabilities of domain transmission from a parental node to its children in the taxonomy tree.",
"fr": "Les paramètres de ces deux modèles sont les probabilités conditionnelles de transmission du domaine d'un nœud parental vers les nœuds fils dans l'arbre... |
1251 | {
"en": "In addition, this strategy allowed us to identify key proteins involved in physiological and contaminant-associated pathways that had not been revealed by the differential analysis used.",
"fr": "De plus, cette stratégie nous a permis d'identifier des protéines clés impliquées dans des voies physiologiques... |
1252 | {
"en": "Our bioinformatics analyzes identified the existence of de novo post-zygotic mutations of genes involved in neural crest development or cancer, in 5 cases.",
"fr": "Nos analyses bio-informatiques ont montré l'existence de mutations de novo post-zygotiques de gènes impliqués dans le développement de la crêt... |
1253 | {
"en": "Applying it to the Tara Oceans dataset allowed me to describe for the first time their distribution in the global ocean and revealed that type IV chromatic acclimation, a process by which cells can match their absorption properties to the ambient light colour, is widespread and constitutes the dominant pigme... |
1254 | {
"en": "The three tools have been rapidly adopted by all the scientists of the research centre and are now daily used for the tracking of all the laboratory's activities but also more globally for the research centre's other scientific activities.",
"fr": "Les trois outils ont été rapidement adoptés par l'ensemble... |
1255 | {
"en": "Given a combination of features at a given genome positions, the SNP model predicts the expected fraction of rare SNPs (a measure of negative selection), and the SOM model predicts the expected mutation density at this position.",
"fr": "Compte tenu de la combinaison de caractéristiques fonctionnelles à un... |
1256 | {
"en": "This would enable powerful deep learning-based prediction of hidden links between drugs and targets.",
"fr": "Cela permettra d'obtenir des prédictions de liens manquants entre les médicaments et les cibles via des méthodes d'apprentissage profond."
} |
1257 | {
"en": "Our data indicated that the activation of the immune response is accompanied by an induction of the accumulation of both CDC48 transcript and protein.",
"fr": "Les principaux résultats obtenus ont montré que l'activation de la réponse immunitaire s'accompagne de l'induction d'une accumulation des transcrit... |
1258 | {
"en": "The laboratory has at its disposal a mutant strain of the haptophyte microalga Tisochrysis lutea producing twice more storage lipids than the wild type strain when exposed to nitrogen deprivation.",
"fr": "Le laboratoire dispose d'une souche mutante de la microalgue haptophyte Tisochrysis lutea produisant ... |
1259 | {
"en": "Large scale Monte-Carlo and molecular dynamics calculations suggest that self-bound clusters are present in the supercritical phase, that is for temperatures above the critical one.",
"fr": "Les calculs de dynamiques moléculaire et Monte-Carlo que nous avons réalisés sur des systèmes de grandes tailles sug... |
1260 | {
"en": "The proposed algorithm has then been assessed on clinical datasets of several patients with non small cell lung carcinoma.",
"fr": "L'algorithme proposé a ensuite été testé sur des données cliniques de patients présentant un cancer bronchique non à petites cellules."
} |
1261 | {
"en": "OA is characterized by articular cartilage degeneration, together with synovitis and abnormal subchondral bone remodeling, leading to progressive loss of mobility and pain.",
"fr": "Elle se caractérise par une dégénérescence du cartilage articulaire associée à une inflammation synoviale et un remodelage an... |
1262 | {
"en": "The selectivity of kinase inhibitors may lead to side effects potentially harmful.",
"fr": "L'absence de sélectivité conduit le plus souvent à des effets secondaires particulièrement néfastes pour l'organisme."
} |
1263 | {
"en": "This work opens up several potential leads for future work on the interactions between amoebae and giant viruses.",
"fr": "Ces travaux ouvrent plusieurs pistes potentielles pour des travaux futurs portant sur les interactions entre les amibes et les virus géants."
} |
1264 | {
"en": "Following the rise of epigenetic, studies on DNA methylation, the most well understood epigenetic mark, showed that the loci of CGB genes and INSL4 are hypomethylated in cancer and placental cells, which may reflect a global hypomethylation also characteristic of these cells.",
"fr": "Avec l'émergence de l... |
1265 | {
"en": "This work required many software developments in the aim to grid enabled bioinformatic applications and transparenlty give access to the Decrypthon grid, but also into DIET middleware and tools around : DIET_Webboard, VizDIET, GoDIET, LogService, MA_DAG, etc.",
"fr": "Ces travaux ont nécessité un développe... |
1266 | {
"en": "The OCP is composed of two domains connected by a flexible linker, the C-terminal domain (CTD) and the N-terminal domain (NTD).",
"fr": "L'OCP est composé de deux domaines), le domaine C-terminal (CTD) et le domaine N-terminal (NTD), reliés par un domaine de liason flexible (linker)."
} |
1267 | {
"en": "Radiotherapy is the main modality in cancer treatment but is associated with radiation damages on healthy tissues.",
"fr": "La radiothérapie constitue l'une des principales modalités de traitement des cancers, mais elle est associée à des atteintes radio-induites aux tissus sains."
} |
1268 | {
"en": "We have shown for the first timethat Hox genes contribute to cardiogenesis. Moreover, genetically labeled cells analysis reveals a common origin of the arterial and venous poles in the cardiac field.",
"fr": "Pour la première fois, nous montrons l'implication des gènes Hox dans la cardiogenèse précoce.L'an... |
1269 | {
"en": "We have shown that there is a model of a photosynthetic system which differs from that of supercomplexes and that the heterogeneity of LH2 is important in the process of adapting.",
"fr": "Nous montrons qu'il existe un modèle de système photosynthétique qui diffère de celui des supercomplexes, et que l'hét... |
1270 | {
"en": "Further investigation in the mdx mouse revealed dysregulation of transcription factors of fatty acid (SREBP1) and cholesterol metabolism (SREBP2), perturbation of the mevalonate pathway, and accumulation of cholesterol in skeletal muscles.",
"fr": "Des investigations chez la souris mdx ont montré une dérég... |
1271 | {
"en": "The goal of our work has been to explore cancer cell mRNA heterogeneity.",
"fr": "Le but de notre travail a été d'explorer l'hétérogénéité des cellules cancéreuses du point de vue de la séquence d'ARN messager."
} |
1272 | {
"en": "NR5A1 is a crucial factor for gonadotrope cell fate determination since it initiates the transcription of key gonadotrope genes such as the GnRH receptor and LH and FSH specific subunits.",
"fr": "NR5A1 est crucial pour l'émergence du lignage gonadotrope puisqu'il permet d'initier l'expression des gènes co... |
1273 | {
"en": "The final objective of the project will be to implement generic methods and tools for the prediction of lncRNAs.",
"fr": "L'objectif final du projet sera de mettre en œuvre des méthodes et des outils génériques pour la prédiction des ARNlncs."
} |
1274 | {
"en": "However, applied to divergent proteins, this strategy may miss several domains.",
"fr": "Cependant, appliquée aux protéines d'organismes divergents, cette méthode manque de sensibilité."
} |
1275 | {
"en": "As bioinformatics was an important part of my work to analyse barcoding/metabarcoding data, a part of my thesis is dedicated to explain these analyses as a tutorial for all future users.",
"fr": "La bioinformatique ayant une part importante dans l'analyse des données de barcoding/metabarcoding, une partie ... |
1276 | {
"en": "Following a presentation of the key steps and developments that have been required to reconstruct a global metabolic model of A. baylyi, we will show that confronting observed and predicted phenotypes highlight inconsistencies between the two scales.",
"fr": "Après avoir présenté les développements effectu... |
1277 | {
"en": "Our pipeline RNA-unchained greatly improves computation time of LocARNA and is comparable to the one of ExpLocP, while improving the overall accuracy of the final alignments.",
"fr": "Notre méthode RNA-unchained permet d'améliorer significativement les temps de calcul de LocARNA et présente des temps de ca... |
1278 | {
"en": "From the theoretical point of view, our contributions to this problem is a new formalisation of the Smallest Grammar Problem based on two complementary optimisation problems: the choice of constituents of the final grammar and the choice of how to parse the sequence with these constituents.",
"fr": "Nous p... |
1279 | {
"en": "We use a model of a “common denominator” for cardiovascular disease (CVD) and other chronic diseases to identify biomarkers linked with common diseases risk factors and molecular pathways.",
"fr": "Nous avons utilisé un modèle de \"dénominateur commun\" pour les maladies chroniques afin d'identifier des bi... |
1280 | {
"en": "In parallel, a bioinformatic work on public banks of genomic DNA from citrus, allowed to identify seven genes with high sequence homologies with those involved in the synthesis of furanocoumarins in Pastinaca sativa (CYP71) and in Arabidopsis thaliana (CYP82).",
"fr": "En parallèle, un travail de bioinform... |
1281 | {
"en": "Psychiatric comorbidities (DSM-5) were ADHD (15/20 patients), anxiety disorders (14/20) and ASD (13/20).",
"fr": "Les comorbidités psychiatriques étaient le TDAH (15/20 patients), les troubles anxieux (14/20) et le TSA (13/20)."
} |
1282 | {
"en": "Second, we provide an analysis of the interface properties of Ig-Ag complexes. In particular, we design a classifier using two descriptors, which is able todistinguish ligand types.",
"fr": "Deuxièmement, nous proposons de nouvelles analyses de complexes Ig-Ag.D'une part nous concevons un classificateur di... |
1283 | {
"en": "Such heterogeneity has so far only been observed in neurodegenerative diseases, particularly in Alzheimer's disease, in which some subsets are proposed to be beneficial or detrimental.",
"fr": "Plusieurs de ces études ont établi une association entre l'hétérogénéité microgliale et les maladies neurodégénér... |
1284 | {
"en": "Each algorithm introduced in this thesis achieves state-of-the-art performances, especially in terms of training speed.",
"fr": "Tous les algorithmes introduits dans cette thèse atteignent les performances de l'état-de-l'art, en particulier en ce qui concerne les vitesses d'entraînement."
} |
1285 | {
"en": "The resulting model is used to study how the constant surface cells renewal impacts the microbiome kinetics.",
"fr": "Le modèle ainsi obtenu est utilisé pour étudier l'impact du renouvellement constant des cellules de surface sur la dynamique du microbiome."
} |
1286 | {
"en": "The thesis is completed by a machine learning method to infer deleterious effects after a genetic variation called INDEL.",
"fr": "La thèse est complétée par une méthode d'apprentissage automatique pour inférer des effets délétères après une variation génétique appelée INDEL."
} |
1287 | {
"en": "Constituent amino-acids can be analyzed to predict secondary, tertiary and quaternary protein structure.",
"fr": "La chaîne d'acides aminés peut être analysée pour prédire les structures secondaire, tertiaire et quaternaires d'une protéine."
} |
1288 | {
"en": "This doctoral thesis describes the main aspects of the LASTec C++ package, which is the core of the SDView project.",
"fr": "Cette thèse décrit les points essentiels du package LASTec, premier ensemble de bibliothèques C++ constituant le coeur du projet SDView."
} |
1289 | {
"en": "We found, that the recruitment of repair components and the phosphorylation of H2AX is governed by pre-existing Topologically Associating Domain (TADs).",
"fr": "Nous avons découvert que le recrutement des composants de réparation et la phosphorylation de H2AX sont régis par des domaines topologiques assoc... |
1290 | {
"en": "Over the course of approximately 100 years, from 1908 till 2000, 10 strains of Phaeodactylum tricornutum (referred to asecotypes) have been collected and stored axenically as cryopreserved stocks at various stock centers.",
"fr": "Au cours d'une centaine d'années environ, de 1908 à 2000, 10 souches de Phae... |
1291 | {
"en": "The aim of this thesis is the study of the transcriptome of the bacterium Buchnera aphidicola, the primary endosymbiont of the pea aphid, Acyrthosiphon pi-sum, by microarray technology.",
"fr": "L'objectif de cette thèse est l'étude par la technologie des puces à ADN, du transcriptome de la bactérie Buchne... |
1292 | {
"en": "Genetic analyses ruled out single gene deficiencies but rather suggested combined effects of multiple factors in the type I IFN induction signaling pathway.",
"fr": "Des analyses génétique et transcriptomique ont exclus des déficiences causées par des gènes uniques et ont favorisé l'hypothèse d'une combina... |
1293 | {
"en": "I have characterized two atypical thioredoxin proteins, one from the anaerobe Desulfovibrio vulgaris Hildenborough, Dtrx, and one from the pathogenic Pseudomonas aeruginosa PAO1, PsTrx.",
"fr": "J'ai caractérisées deux thiorédoxines atypiques, l'une provenant de l'organisme anaérobie Desulfovibrio vulgaris... |
1294 | {
"en": "A major objective of this thesis was to apply Transposon-Directed Insertion Sequencing (TraDIS) to detect mutants with reduced intracellular survival and virulence in zebrafish embryos.",
"fr": "Le premier objectif de cette thèse est d'utiliser la technique de TraDIS (transposon-directed insertion sequenci... |
1295 | {
"en": "Within this dissertation, I introduce the state of the art of pangenome visualization: I distinguish pan-gene from pangenomes, the latter often being represented by pangenome graphs where each sequence is a node and each observed sequence succession forms an edge; I also identify unspecific, qualifying, posi... |
1296 | {
"en": "I have characterized in vitro some of these terminators, particularly in 5'UTRs, with the hope that they will be involved in conditional regulatory mechanisms.",
"fr": "J'ai caractérisé in vitro certains de ces terminateurs, en particulier dans les régions 5'UTR, avec l'espoir qu'ils soient impliqués dans ... |
1297 | {
"en": "Our work revealed that direct developmental exposure to CD leads to impairment of meiosis in male and female mice, causes a reduction in viable reproductive cells, i.e., both spermatogonia and spermatozoid, and oocytes in females.",
"fr": "Les travaux réalisés dans le cadre de cette thèse ont révélé qu'une... |
1298 | {
"en": "The manuscript describes how we applied the 2P2I approach to several research projects to design antiviral drugs as well as the modeling tools and strategies we developed.",
"fr": "Le manuscrit décrit l'application de l'approche 2P2I à plusieurs projets de recherche pour la conception d'antiviraux ainsi qu... |
1299 | {
"en": "Their corresponding genes form an operon temporarily induces in early growth phase.",
"fr": "Leurs gènes forment un opéron induit temporairement en début de croissance."
} |
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