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### Question: Does serum albumin predict survival in patients with hilar cholangiocarcinoma? ### Context: Hilar cholangiocarcinoma is a devastating malignancy with incidence varying by geography and other risk factors. Rapid progression of disease and delays in diagnosis restrict the number of patients eligible for cur... |
### Question: Is decrease in glomerular filtration rate in Japanese patients with type 2 diabetes linked to atherosclerosis? ### Context: We assessed the effects of atherosclerosis on the glomerular filtration rate (GFR) in patients with type 2 diabetes and who had micro- or normoalbuminuria.A total of 61 Japanese pati... |
### Question: Does timing of upper endoscopy influence outcomes in patients with acute nonvariceal upper GI bleeding? ### Context: Current guidelines advise that upper endoscopy be performed within 24 hours of presentation in patients with acute nonvariceal upper gastrointestinal bleeding (UGIB). However, the role of u... |
### Question: Is maximum predictive power of the microarray-based models for clinical outcomes limited by correlation between endpoint and gene expression profile? ### Context: Microarray data have been used for gene signature selection to predict clinical outcomes. Many studies have attempted to identify factors that ... |
### Question: Does neuromuscular electrical stimulation-assisted gait increase muscle strength and volume in children with unilateral spastic cerebral palsy? ### Context: To determine if neuromuscular electrical stimulation (NMES) applied to the ankle dorsiflexors during gait improves muscle volume and strength in chil... |
### Question: Can severely impaired cortical transit predict which children with pelvi-ureteric junction stenosis detected antenatally might benefit from pyeloplasty? ### Context: Until recently, renogram, performed in children with pelvi-ureteric junction stenosis detected antenatally, has not been able to predict the... |
### Question: Is pulsatile distension of the proximal aneurysm neck larger in patients with stent graft migration? ### Context: The proximal abdominal aortic aneurysm (AAA) neck expands significantly during the cardiac cycle, both before and after endovascular aneurysm repair (EVAR). Clinical consequences of this pulsa... |
### Question: Ki-67: a prognostic factor for low-grade glioma? ### Context: Immunohistochemical techniques were used to detect the expression of Ki-67, a nuclear proliferation marker, in 180 low-grade glioma tumor specimens to determine whether Ki-67 is a prognostic predictor of survival or tumor recurrence.A clinical ... |
### Question: Does caffeic acid phenethyl ester reduce mortality and sepsis-induced lung injury in rats? ### Context: Sepsis and ensuing multiorgan failure continue to be the major causes of mortality in intensive care units. Nuclear factor (NF)-kappaB activation is supposed to be one of the targets in the treatment of... |
### Question: Are bone marrow-derived cells recruited by the melanoma tumor with endothelial cells contributing to tumor vasculature? ### Context: Tumor expansion is dependent on neovascularization, a process that requires sustained new vessel formation. Although the critical role of angiogenesis by endothelial sprouti... |
### Question: Is an imbalance of COX level related to placental abruption? ### Context: Muscularised basal plate arteries (MA) or chorioamnionitis (CA) are often present in placental abruption. The aim of this study was to evaluate the placental expression of COX 1 and COX 2 in cases of placental abruption with MA or C... |
### Question: Is epidemiologic features of invasive pneumococcal disease in Belgian children : passive surveillance enough? ### Context: Reliable epidemiologic surveillance of infectious diseases is important for making rational choices for public health issues such as vaccination strategies. In Belgium, as in most Eur... |
### Question: Does familial adenomatous polyposis predispose to pathologic exposure of the stomach to bilirubin? ### Context: The role of duodenogastric reflux in the genesis of gastric polyps in familial adenomatous polyposis (FAP), although suggested by scintigraphy scanning studies, remains unclear.Twenty-four hour ... |
### Question: Is pancreaticoduodenectomy justified for septuagenarians and octogenarians? ### Context: Almost all of the studies described elderly as beginning at the age 70 and very few focused on the group of patients over 80 years of age. This study was undertaken to compare the surgical risk and prognosis between s... |
### Question: Does temporal refinement affect predicted human chorionic gonadotropin rise in early pregnancy? ### Context: To examine the impact of validation and temporal resolution of estimation of hCG increase, because patients' hCG values are not obtained at precise daily increments or always in the same laboratory... |
### Question: Does increased miR-195 aggravate neuropathic pain by inhibiting autophagy following peripheral nerve injury? ### Context: Following peripheral nerve injury (PNI) microglia proliferates and adopts inflammation that contributes to development and maintenance of neuropathic pain. miRNAs and autophagy are two... |
### Question: Is PLC repair of a peel-off femoral lesion an effective option in a multiligament setting? ### Context: Treatment of posterolateral corner (PLC) injury in the multiligament-injured knee is still controversial. The aim of this study was to investigate the clinical outcome of acute or sub-acute surgical rep... |
### Question: Are pregnancy complications frequent in long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency? ### Context: Preeclampsia-related complications of pregnancy have been detected in carriers of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency, a recently discovered disorder of mitochondrial... |
### Question: Is there variability in the attainment of developmental milestones in the CDKL5 disorder? ### Context: Individuals with the CDKL5 disorder have been described as having severely impaired development. A few individuals have been reported having attained more milestones including walking and running. Our ai... |
### Question: Is second-generation colon capsule endoscopy feasible in the out-of-clinic setting? ### Context: No colorectal imaging test may be performed on an out-of-clinic basis. This represents a major drawback compared with fecal tests. Because colon capsule endoscopy (CCE) automatically detects small bowel mucosa... |
### Question: Genome-wide analysis of Ollier disease: Is it all in the genes? ### Context: Ollier disease is a rare, non-hereditary disorder which is characterized by the presence of multiple enchondromas (ECs), benign cartilaginous neoplasms arising within the medulla of the bone, with an asymmetric distribution. The ... |
### Question: Does estradiol supplementation suppress hyperventilation-induced attacks in postmenopausal women with variant angina? ### Context: We sought to examine whether estradiol (E2) supplementation suppresses anginal attacks in women with variant angina.Estrogen is known to improve endothelial function. Coronary... |
### Question: Is hepatocyte growth factor/c-Met signalling important for the selection of transplanted hepatocytes? ### Context: At present hepatocyte transplantation is a promising option for cellular therapy of end-stage liver diseases. However, the underlying molecular mechanisms need to be better defined in order t... |
### Question: Are unaudited records from an outcomes registry database accurate? ### Context: Data from outcomes registry databases are being increasingly used for peer review and public reporting. However, administrative and clinical databases are mostly unaudited; thus, their accuracy has not been verified.Outcomes d... |
### Question: Does urine proteomic analysis differentiate cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders? ### Context: Diagnosis and curative treatment of cholangiocarcinoma (CC) often comes too late due to the lack of reliable tumour markers especially in patients with primar... |
### Question: Is low serum bilirubin concentration a predictor of chronic kidney disease? ### Context: Chronic kidney disease (CKD) is a worldwide public health problem. It is very important to identify the factors that affect CKD. Previous studies have reported that serum bilirubin concentration was positively correla... |
### Question: Is increased expression of MMP9 correlated with poor prognosis of nasopharyngeal carcinoma? ### Context: The aim of the present study was to analyze the expression of matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including the surv... |
### Question: Does angiotensin converting enzyme-inhibitor reduce colitis severity in an IL-10 knockout model? ### Context: We previously demonstrated angiotensin converting enzymes (ACE) over-expression in a dextran-sodium sulfate colitis model; ACE inhibitor (ACE-I) treatment reduced colitis severity in this model. H... |
### Question: Does tumor endothelial marker 8 enhance tumor immunity in conjunction with immnization against differentiation Ag? ### Context: We have previously shown that xenogenic DNA vaccines encoding rat neu and melanosomal differentiation Ag induce tumor immunity. Others have developed vaccines targeting tumor neo... |
### Question: Is interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI associated with ( 31 ) P MRS-detectable energy failure? ### Context: It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1β), in ... |
### Question: Is biallelic inactivation of the APC gene associated with hepatocellular carcinoma in familial adenomatous polyposis coli? ### Context: Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli ... |
### Question: Does [ Arm adduction increase block extension in anesthesia of the brachial plexus by the axillary approach ]? ### Context: Arm abduction of 90 degrees during injection of local anesthetic followed by adduction of the arm has been recommended traditionally to favor proximal distribution of local anestheti... |
### Question: Do relative quantification of human β-defensins by a proteomics approach based on selected reaction monitoring? ### Context: A targeted proteomics method based on selected reaction monitoring (SRM) is a relevant approach for the analysis of multiple analytes in biological samples. Defensins are phylogenet... |
### Question: Are pregnane X receptor and hepatocyte nuclear factor 4α polymorphisms cooperatively associated with carbamazepine autoinduction? ### Context: We attempted to clarify the influence of polymorphisms of nuclear receptors on carbamazepine therapy.The common polymorphisms of nuclear receptors--a tentative pre... |
### Question: Does a pangenomic analysis of the Nannochloropsis organellar genomes reveal novel genetic variations in key metabolic genes? ### Context: Microalgae in the genus Nannochloropsis are photosynthetic marine Eustigmatophytes of significant interest to the bioenergy and aquaculture sectors due to their ability... |
### Question: Is kidney function associated with severity of white matter hyperintensity in patients with acute ischemic stroke/TIA? ### Context: Previous studies suggested the potential interactions between cerebrovascular diseases and impaired renal function. However, the relationship between renal function and white... |
### Question: Microparticle association and heterogeneity of tumor-derived tissue factor in plasma: is it important for coagulation activation? ### Context: Tumor-derived tissue factor (TF) activates coagulation in vitro and in vivo in an orthotopic model of human pancreatic cancer. Here, we further characterized tumor... |
### Question: Is obesity a favorable factor for resectability of rectal cancer? ### Context: It is well established that unresectable rectal tumors have a detrimental effect on long-term survival. Predictive factors for resectability focused on the body mass index and surgeon case volume were assessed in the present st... |
### Question: Are younger women with diminished oocyte reserve more prone to meiosis errors leading to spontaneous abortion than their age peers with normal oocyte reserve? ### Context: To determine the relative effect of age vs ovarian oocyte reserve on miscarriage rates.Miscarriage rates (loss of pregnancy establishe... |
### Question: Does crystal structure analysis reveal functional flexibility in the selenocysteine-specific tRNA from mouse? ### Context: Selenocysteine tRNAs (tRNA(Sec)) exhibit a number of unique identity elements that are recognized specifically by proteins of the selenocysteine biosynthetic pathways and decoding mac... |
### Question: Do human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells? ### Context: Coinfection with hepatitis C virus (HCV) is present in one-third of all human immunodeficiency virus (HIV)-infected individuals in the United States and is associat... |
### Question: Does diagnosis of pneumonia in the ED have poor accuracy despite diagnostic uncertainty? ### Context: In 2007, the Centers for Medicare and Medicaid Services created a measure known as "diagnostic uncertainty" in emergency department (ED) pneumonia admissions. This documentation excludes the antibiotic ti... |
### Question: Does level of beta-adrenergic receptor kinase 1 inhibition determine degree of cardiac dysfunction after chronic pressure overload-induced heart failure? ### Context: Heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial bet... |
### Question: Is the determination of the soluble interleukin-2 receptor after application of interleukin-2 receptor antibodies still appropriate for immunological monitoring after renal transplantation? ### Context: The use of monoclonal antibodies against the alpha-chain of the membrane-bound interleukin-2 receptor (... |
### Question: Do immune responses to AAV in a phase I study for Canavan disease? ### Context: Canavan disease is a rare leukodystrophy with no current treatment. rAAV-ASPA has been developed for gene delivery to the central nervous system (CNS) for Canavan disease. This study represents the first use of a viral vector ... |
### Question: Does simultaneous transurethral resection of bladder tumor and prostate affect the recurrence of bladder tumor? ### Context: To evaluate the efficacy and safety of simultaneous resection in the treatment of nonmuscle invasive bladder cancer (NMIBC) with benign prostatic hyperplasia (BPH).Combined publishe... |
### Question: Emergency department waiting times: Do the raw data tell the whole story? ### Context: To determine whether there are real differences in emergency department (ED) performance between Australian states and territories.Cross-sectional analysis of 2009-10 attendances at an ED contributing to the Australian ... |
### Question: Does variation in White Matter Connectivity predict the Ability to Remember Faces and Discriminate Their Emotions? ### Context: The extended face network contains clusters of neurons that perform distinct functions on facial stimuli. Regions in the posterior ventral visual stream appear to perform basic p... |
### Question: Does platelet-derived sphingosine 1-phosphate induce migration of Jurkat T cells? ### Context: The migration of T cell to atherosclerotic lesions is proposed to be involved in the pathogenesis of the atherosclerosis. Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid released from activated plate... |
### Question: Does risk factors of fall in community dwelling active elderly? ### Context: To search for measures to describe and relate to accidental falls in community dwelling elderly.A EuroQol EQ-5D questionnaire based on a patient's otoneurological case history provided a general health related quality of life mea... |
### Question: Does [ Human platelet lysates promote the proliferation of mesenchymal stem cells in vitro ]? ### Context: To investigate the effect of human platelet lysates (HPL) obtained from platelet-rich plasma on the proliferation and biological characteristics of human mesenchymal stem cells (MSCs) in vitro.HPL wa... |
### Question: Can We Predict Oral Antibiotic Treatment Failure in Children with Fast-Breathing Pneumonia Managed at the Community Level? ### Context: Pneumonia is the leading cause of infectious death amongst children globally, with the highest burden in Africa. Early identification of children at risk of treatment fai... |
### Question: Is interleukin-1B ( -511 ) gene polymorphism associated with acute coronary syndrome in the Turkish population? ### Context: acute coronary syndrome (ACS) is defined as an inflammatory disease associated with development of atherosclerosis and instability. IL-1 is a candidate inflammatory cytokine that is... |
### Question: Do changes in aortic blood flow induced by passive leg raising predict fluid responsiveness in critically ill patients? ### Context: Esophageal Doppler provides a continuous and non-invasive estimate of descending aortic blood flow (ABF) and corrected left ventricular ejection time (LVETc). Considering pa... |
### Question: Coccygectomy for coccygodynia: do we really have to wait? ### Context: Of 81 patients with coccygodynia, 21 underwent surgical excision of the coccyx with a minimum 5 days of antibiotic prophylaxis. All 21 patients were followed for at least 2 years and questioned about their satisfaction with the operati... |
### Question: Does recombinant activated factor VII increase survival time in a model of incompressible arterial hemorrhage in the anesthetized pig? ### Context: Hemorrhage is the leading cause of death in battlefield casualties and the second leading cause of death after civilian trauma. Evacuation time for military c... |
### Question: Does deep Brain Stimulation of the Subthalamic Nucleus improve Lexical Switching in Parkinsons Disease Patients? ### Context: Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To... |
### Question: Can prescription refill feedback to physicians improve patient adherence? ### Context: Although adherence to long-term drug therapy is an important issue, the means to facilitate its assessment and improvement in clinical practice remain a challenge.To evaluate the impact of prescription refill feedback a... |
### Question: Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? ### Context: Although women are at consistently greater risk for major depression (MD) than men, it is unclear whether sex modifies the aetiological impact of genetic factors ... |
### Question: Is the ICH score a valid predictor of mortality in intracerebral hemorrhage? ### Context: The intracerebral hemorrhage (ICH) score utilizes a 0- to 6-point scoring system to predict 30-day mortality in ICH patients. The purpose of this analysis was to (a) validate the ICH score in an international, hetero... |
### Question: Does natural history comparisons of primary and secondary progressive multiple sclerosis reveal differences and similarities? ### Context: Similarities in the onset age of progression in secondary-progressive (SP) and primary-progressive multiple sclerosis (PPMS) have been previously reported. However, wi... |
### Question: Are clinical parameters and functional tests predictive for in-stent restenosis? ### Context: To study the correlation between clinical parameters and the occurrence of in-stent restenosis in a cohort of patients from the Tel Aviv Medical Center who underwent repeat angiograms for clinical indications fol... |
### Question: Choroid plexus cysts: Is biochemical testing a valuable adjunct to targeted ultrasonography? ### Context: We sought to determine whether biochemical testing is a valuable adjunct to ultrasonography in selecting patients with fetal choroid plexus cysts for amniocentesis.The study population consists of 128... |
### Question: Does oral baclofen administration in persons with chronic spinal cord injury prevent the protective effects of spasticity on body composition and glucose homeostasis? ### Context: Correlation study.To determine the effects of oral baclofen on body composition (fat mass (FM), fat-free mass (FFM)), extra- a... |
### Question: Does blood pressure reactivity to psychological stress predict hypertension in the CARDIA study? ### Context: A longstanding but controversial hypothesis is that individuals who exhibit frequent, large increases in blood pressure (BP) during psychological stress are at risk for developing essential hypert... |
### Question: Do ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model? ### Context: Ospemifene, a new drug indicated for the treatment of vulvovaginal atrophy, has completed phase III clinical trials. A condition affecting millions of women worldwide, vulv... |
### Question: Is sustained inflammation 1.5 years post-stroke associated with depression in elderly stroke survivors? ### Context: Depression is common in elderly stroke survivors and has been associated with systemic inflammation. We aimed to investigate an elderly population of Swedish stroke patients for evidence of... |
### Question: Does prostate size predict high grade cancer? ### Context: Several radical prostatectomy series have linked small prostates with high grade cancer based on the hypothesis that a small prostate results from a low androgen milieu that selects for less hormone dependent, more aggressive tumors. We previously... |
### Question: Lower mini-sternotomy in congenital heart disease: just a cosmetic improvement? ### Context: Lower mini-sternotomy represents a minimally invasive surgical technique that has been utilized for the repair of a wide variety of congenital heart defects with excellent surgical and cosmetic outcomes. However, ... |
### Question: Does eMX2 be a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas? ### Context: Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer (NSCLC). Current staging methods do not adequately predict outcome for this disease. EMX2 is a homeo-domain c... |
### Question: Is grade three disc degeneration a critical stage for anterior spondylolisthesis in lumbar spine? ### Context: Little is known about when and how progressive spondylolisthesis occurs. In this report segmental motion related to age and disc degeneration at L4/5 disc was investigated.637 patients with low b... |
### Question: Can undergraduate education have an effect on the ways in which pre-registration house officers conceptualise communication? ### Context: In 1994 Manchester Medical School introduced a learner-centred course using problem-based learning (PBL), which emphasises effective communication skills. This study ex... |
### Question: Recovery after brain damage: Is there any indication for generalization between different cognitive functions? ### Context: The question whether recovery in various cognitive functions is supported by one or two more fundamental functions (for instance, attentional or working memory functions) is a long-s... |
### Question: Does a pre-conditioning stress accelerate increases in mouse plasma inflammatory cytokines induced by stress? ### Context: Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rod... |
### Question: Are hernias the most common cause of strangulation in patients presenting with small bowel obstruction? ### Context: Small bowel obstruction (SBO) is a leading cause of admission to surgical emergency units. Strangulation is associated with a 10-fold increase in mortality. The aim of the present study was... |
### Question: Does cryoprobe biopsy increase the diagnostic yield in endobronchial tumor lesions? ### Context: Forceps biopsy is the standard method to obtain specimens in endoscopically visible lesions. It is common to combine forceps biopsy with cytology methods to increase the diagnostic yield. Although the flexible... |
### Question: Does efficient overproduction of membrane proteins in Lactococcus lactis require the cell envelope stress sensor/regulator couple CesSR? ### Context: Membrane proteins comprise an important class of molecules whose study is largely frustrated by several intrinsic constraints, such as their hydrophobicity ... |
### Question: Does age affect gastric emptying time? ### Context: Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than in older children and adults. The aim of this study was to investigate the impact of age and other covariates on the rate of GE.The effect of age on the me... |
### Question: The two-week pediatric surgery rotation: is it time wasted? ### Context: With increasing medical school emphasis on generalist training and decreasing enrollment in surgical residency, the authors assessed the adequacy of a 2-week pediatric surgery rotation on meeting the learning and competency objective... |
### Question: Is functional PstI/RsaI polymorphism in CYP2E1 associated with the development , progression and poor outcome of gastric cancer? ### Context: Cytochrome P450 2E1 (CYP2E1), an ethanol-inducible enzyme, has been shown to metabolically activate various carcinogens, which is critical for the development and p... |
### Question: Digital photoplethysmography in the diagnosis of suspected lower limb DVT: is it useful? ### Context: to determine the role of digital photoplethysmography (D-PPG) in the diagnosis of deep-vein thrombosis (DVT), in comparison to the "gold standard" of either contrast ascending venography (ACV) or colour-f... |
### Question: Does a distinct metabolic signature predict development of fasting plasma glucose? ### Context: High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of im... |
### Question: Does preoperative magnetic resonance imaging reduce the rate of positive surgical margins at radical prostatectomy in a randomised clinical trial? ### Context: Magnetic resonance imaging (MRI) has the potential to help the surgeon tailor radical prostatectomy (RP) more accurately according to the location... |
### Question: Does tLE6 mutation cause the earliest known human embryonic lethality? ### Context: Embryonic lethality is a recognized phenotypic expression of individual gene mutations in model organisms. However, identifying embryonic lethal genes in humans is challenging, especially when the phenotype is manifested a... |
### Question: Does peritoneal mobilization increase laparoscopic acidosis? ### Context: It was hypothesized that laparoscopic colon surgery may be associated with increased absorption of CO2 resulting from mobilization of lateral peritoneal reflections.Six pigs underwent laparotomy with removal of a measured quadrant o... |
### Question: Is retinal neovascularization suppressed with a matrix metalloproteinase inhibitor? ### Context: To determine the role of extracellular proteinases in ischemia-induced retinal neovascularization in an animal model and to examine the effect of proteinase inhibitors on retinal neovascularization.Retinal neo... |
### Question: Are successful resident clinicians good teachers? ### Context: GME training programs must demonstrate residents are prepared as both teachers and clinicians. We examined the relationship between faculty evaluations of residents' clinical performance and student evaluations of residents' teaching performan... |
### Question: Do sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations? ### Context: HLA/MHC class II molecules show high degree of polymorphism in the human population. The individual polymorphic motifs have been suggested to be propagated and mixed by transfer of genetic ma... |
### Question: Does oligodendroglial deletion of ESCRT-I component TSG101 cause spongiform encephalopathy? ### Context: Vacuolation of the central nervous system (CNS) is observed in patients with transmissible spongiform encephalopathy, HIV-related encephalopathy and some inherited diseases, but the underlying cellular... |
### Question: Does telomerase deficiency in bone marrow-derived cells attenuate angiotensin II-induced abdominal aortic aneurysm formation? ### Context: Abdominal aortic aneurysms (AAA) are an age-related vascular disease and an important cause of morbidity and mortality. In this study, we sought to determine whether t... |
### Question: Does hypercholesterolemia promote leukocyte-dependent platelet adhesion in murine postcapillary venules? ### Context: Leukocyte-platelet aggregates form in blood during the development of cardiovascular diseases, including atherosclerosis. The study determined whether leukocytes contribute to the platelet... |
### Question: Does cervical spinal cord stimulation increase cerebral cortical blood flow in an experimental cerebral vasospasm model? ### Context: Cerebral microcirculatory changes during cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH) are still controversial and uncertain. The aim of our study is t... |
### Question: Does surveillance of duodenal adenomas in familial adenomatous polyposis reveal high cumulative risk of advanced disease? ### Context: The development of high-grade dysplasia (HGD) on duodenal or jejunal adenomas and of late-stage (stage IV) duodenal polyposis are major clinical events for familial adenom... |
### Question: Does deep anesthesia worsen outcome of rats with inflammatory responses? ### Context: We tested the hypothesis that deep anesthesia with sevoflurane, known as a potent immunomodulator, for 4 h would worsen the 24-h outcomes of rats through modulation of the inflammatory responses.Forty-nine male Wistar ra... |
### Question: Does bAD phosphorylation determine ovarian cancer chemosensitivity and patient survival? ### Context: Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cance... |
### Question: Does a short tapered stem reduce intraoperative complications in primary total hip arthroplasty? ### Context: While short-stem design is not a new concept, interest has surged with increasing utilization of less invasive techniques. Short stems are easier to insert through small incisions. Reliable long-t... |
### Question: Is sutured repair of primary small umbilical and epigastric hernias : concomitant rectus diastasis a significant risk factor for recurrence? ### Context: Umbilical and epigastric hernias are common in the adult population and prompt repair is advised. We aimed to evaluate the impact of concomitant rectus ... |
### Question: Does resveratrol mediate therapeutic hepatic effects in acquired and genetic murine models of iron-overload? ### Context: Abnormal iron metabolism and hepatic iron-overload is a major cause of liver injury and in the development of chronic liver diseases. Iron-overload-mediated liver disease leads to end-... |
### Question: Does collateral circulation on perfusion-computed tomography-source images predict the response to stroke intravenous thrombolysis? ### Context: Perfusion-computed tomography-source images (PCT-SI) may allow a dynamic assessment of leptomeningeal collateral arteries (LMC) filling and emptying in middle ce... |
### Question: Is impaired baroreflex sensitivity correlated with hemodynamic deterioration of sustained ventricular tachycardia? ### Context: The goal of this study was to evaluate clinical and autonomic variables (heart rate variability and baroreflex sensitivity) related to hemodynamic tolerability of VT in patients ... |
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