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pair_31418376 | To investigate the clinical significance of bone marrow microvessel density(MVD) and angiogenesis related factors in multipic myeloma(MM). Twenty cases of MM and 20 cases of simple fracture were selected and enrolled in MM group and control group respectively. The clinical data and results of laboratorial tests were co... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 骨髓微血管密度及血管相关生成因子在多发性骨髓瘤中的意义. 探讨骨髓微血管密度及血管相关生成因子在多发性骨髓瘤中的临床意义. 选取2014年1月到2017年12月就诊于本院就诊的多发性骨髓瘤（MM）患者和单纯骨折患者各20例并分别纳入MM组和对照组，收集患者入院基本临床资料，通过改良的塑料包埋骨髓活组织病理切片和免疫组织化学染色检测患者骨髓微血管密度（MVD）；ELISA法检测骨髓上清VEGF、TNF-α、HGF、TGF-α、TGF-β1、bFGF、ANG-Ⅰ、ANG-Ⅱ等血管生成相关因子的水平；real-time-PCR检测骨髓单个核细胞的上述因子mRNA表达水平，pearson相关分析MVD与骨髓上清VEGF、HGF、bFGF水平... | zh-cn |
pair_31418377 | To investigate the significance of neutrophil/lymphocyte ratio(NLR) and platelet/lymphocyte ratio(PLR) in patients with multiple myeloma (MM). Eighty patients with multiple myeloma admitted in our hospital from August 2007 to August 2010 were selected. The clinical data of the patients, including hemoglobin (Hb), mean ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 中性白细胞/淋巴细胞比例和血小板/淋巴细胞比例变化在多发性骨髓瘤患者中的意义. 探讨中性白细胞/淋巴细胞（NLR）比例和血小板/淋巴细胞比例（PLR）变化在多发性骨髓瘤（MM）患者中的意义. [HTK]收集2007年8月至2010年8月本院收治的多发性骨髓瘤患者80例，记录并分析患者的临床资料，包括血红蛋白（Hb）、平均红细胞体积（MCV）、红细胞平均血红蛋白量（MCH）、平均红细胞血红蛋白浓度（MCHC）、红细胞分布宽度（RDW）、白细胞计数（WBC）、中性粒细胞绝对数（ANC）、血小板数目（PC）、肾小球滤过率（GFR）、血钙、白蛋白、β2微球蛋白等. ROC曲线分析预测预后的NLR最佳阈值为2.78（敏感性为83.3%，特异性... | zh-cn |
pair_31418378 | To investigate the relationship of cytogenetic features, clinical characteristics and prognosis in patients with myelodysplastic syndrome. The clinical characteristics and prognosis of 236 patients with MDS admitted to the Affiliated Hospital of Xuzhou Medical University from January 2013 to September 2017 were analyze... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 236例骨髓增生异常综合征患者细胞遗传学特征与临床预后分析. 探讨骨髓增生异常综合征(MDS)患者的细胞遗传学特征、临床特点和预后的关系. 回顾性分析2013年1月至2017年9月徐州医科大学附属医院收治的236例MDS初诊患者的临床特征及预后情况，随访观察并进行相关性分析. 难治性血细胞减少伴单系发育异常(RCUD) 33例，难治性贫血伴环状铁粒幼红细胞(RARS) 8例，难治性血细胞减少伴多系发育异常(RCMD) 70例，难治性贫血（RA） 23例，难治性贫血伴原始细胞过多(RAEB-1 ) 46例，（RAEB-2） 48例，MDS-U 2例，单纯del（5q） 6例。RAEB组(RAEB-1+RAEB-2)染色体异常检出率及复... | zh-cn |
pair_31418380 | To study the correlation of IL-37 with T lymphocytes subsets and NK cells in ITP patients, and to explore its possible mechanisms involved in the pathogenesis of ITP. Forty-five patients with newly diagnosed ITP(newly diagnosed group), 32 patients of complete remission (remission group) and 22 healthy persons(control g... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 原发免疫性血小板减少症(ITP) 患者外周 IL-37的水平变化及其与T亚群、NK细胞的相关性研究. 分析ITP 患者外周血IL-37表达水平变化及其与T亚群、NK细胞数的相关性，探讨其参与疾病发病的可能机制. 选取初诊组ITP 患者45 例，完全缓解组ITP 患者32例及正常对照组22例。采用酶联免疫吸附试验法( ELISA) 测定3 组外周血血清中IL-37水平，应用实时荧光定量聚合酶链式反应(PCR) 测定3 组外周单个核细胞内IL-37、IL-18、IL-17 mRNA 相对表达水平,采用流式细胞术(FCM) 检测3 组IL-18Rα<sup>+</sup>CD4<sup>+</sup> T细胞比例，2组Tim-3<sup>... | zh-cn |
pair_31418382 | To evaluate the clinical efficacy of low dose combined chemotherapy（LDCC） for patients with relapsed and refractory aplastic anemia-paroxysmal nocturnal hemoglobinuria（AA-PNH） syndrome, and to analyze the advantages of LDCC in the treatment of AA-PNH syndrome. The clinical characteristics and the curative effect of LDC... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 低剂量联合化疗治疗复发难治的再生障碍性贫血-阵发性睡眠性血红蛋白尿综合征的疗效. 评价低剂量MP方案与HA方案治疗复发难治的再生障碍性贫血-阵发性睡眠性血红蛋白尿（AA-PNH）综合征患者的治疗效果，探讨低剂量联合化疗在治疗AA-PNH综合征方面的优势. 回顾分析9例复发难治的AA-PNH综合征患者临床特征及采用低剂量联合化疗的疗效，其中5例予MP方案（马法兰2 mg/(m<sup>2</sup>·d)，泼尼松0.5 mg/(kg·d)，口服，d 1-7），4例予HA方案（高三尖杉酯碱2 mg/d，阿糖胞苷100 mg/d，静滴，d 1-5），比较不同患者治疗前后PNH克隆、激素用量及溶血指标的变化，同时比较疾病复发、输血依赖及不良... | zh-cn |
pair_31418383 | To evaluate the diagnostic value of high-throughput sequencing (NGS) in screening the thalassemia genes. The peripheral blood of 2 858 cases of pre-pregnancy and pregnancy from October 2014 to October 2016 randomly were collected in department of obstetrics, the third people's hospital in Dongguan city. Peripheral bloo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 高通量测序技术筛检地中海贫血的临床意义. 评价高通量测序（NGS）技术在地中海贫血基因筛查中的诊断价值. 收集2014年10月- 2016年10月在东莞市第三人民医院产科进行孕前或孕期检查的2 858例广东户籍夫妇的外周血，进行血常规检测、血红蛋白电泳分析，传统地中海贫血基因筛查及高通量测序. 运用NGS筛选α地中海贫血和β地中海贫血的漏诊率分别为0.87%、1.59%，传统筛查模式筛选α地中海贫血和β地中海贫血的漏诊率分别为26.77%、2.38%；运用NGS筛选α地中海贫血和β地中海贫血ROC曲线下面积分别为0.994和0.991，而传统筛查模式筛选的地中海贫血ROC曲线下面积分别为0.866和0.988；运用NGS进行α和β地... | zh-cn |
pair_31418384 | To investigate the genetic carrier rate of thalassemia and its gene mutation types as well as the distribution characteristics among the people in Lingshui Li autonomous county of Hainan province, so as to provide the basis for making the prevention programs of thalassemia in administrative departments. Samples were co... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 海南省陵水黎族自治县育龄夫妇地中海贫血基因检测结果分析. 研究海南省陵水黎族自治县人群地中海贫血基因携带率、基因突变类型及其分布情况，为政府部门拟定合适的地中海贫血防控方案提供依据. 收集陵水县育龄夫妇地中海贫血初筛阳性标本，并检测中国人常见3种缺失型α-地中海贫血基因、3种突变型α-地中海贫血基因、17种β-地中海贫血基因，并分析检测结果. 陵水县育龄人群地中海贫血基因检出率为19.41%（274/1412），α-地中海贫血占地中海贫血基因携带病例83.21%（228/274），β-地中海贫血占地中海贫血病例8.03%（22/274），α-合并β-地中海贫血占地中海贫血病例8.76%（28/274）. 陵水黎族自治县地中海贫血基因... | zh-cn |
pair_31418385 | To analyze the genotype and hematological characteristics of children with αβ-thalassemia in Shenzhen area of China. The erythrocyte parameters and hemoglobin components of the children were determined by blood routine examination and capillary electrophoresis (CE). Reverse dot blot (RDB) -polymerase chain reaction (PC... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 小儿αβ复合型地中海贫血基因型和表型分析. 分析深圳地区小儿αβ复合型地中海贫血的基因型以及血液学特征. 采用血常规和毛细管电泳对患儿红细胞参数和血红蛋白组分进行分析，采用反向点杂交（RDB）技术检测α和β地中海贫血基因点突变，应用跨越断裂点PCR（Gap-PCR）法检测α缺失型地中海贫血和α三联体，巢式PCR检测疑似HKαα地中海贫血的样本. 在74例αβ复合型地中海贫血中共计检出29种复合基因类型，其中1例β地中海贫血合并αααanti4.2/αα和5例双重杂合β地中海贫血复合α地中海贫血有中间型地中海贫血的表型，1例β-28/βcap+40-43双重杂合合并--<sup>SEA</sup>/αα和其余的62例均表现为轻型β地中... | zh-cn |
pair_31418386 | To investigate the predictive effect of platelet activation index expression before and after adenosine bisphosphate activation on bleeding risk in patients with primary immune thrombocytopenia (ITP). Eighty-nine patients with ITP admitted in our hospital from January 2017 to October 2018 were selected and inrolled in ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | ITP患者二磷酸腺苷激活前后血小板活化指标表达对患者出血风险的预测作用研究. 研究原发免疫性血小板减少症（ITP）患者二磷酸腺苷激活前后血小板活化指标表达对患者出血风险的预测作用. 选择我院2017年1月- 2018年10月住院治疗的ITP患者89例为ITP组，采用ITP 特异性出血评价工具（ITP-BAT）进行出血评分及出血程度分级。根据出血程度分为4个亚组：无出血症状组（19例），轻度出血组（32例），中度出血组（27例），大量及严重出血组（11例）。选择同期健康体检者22例为对照组，所有受检者均以二磷酸腺苷（ADP）为激活剂，应用流式细胞术检测激活前后血小板膜糖蛋白（GP）Ⅰb、Ⅱb/Ⅲa 和P选择素表达，分析GPⅠb、GPⅡ... | zh-cn |
pair_31418388 | To analyze the clinical outcomes of engraftment, graft-versus-host disease (GVHD) and survival in the patients with AML1-ETO positive acute myeloid leukemia (AML) treated with unrelated umbilical cord blood transplantation (UCBT). Forty-Five patients with high-risk refractory AML1-ETO positive AML were treated with a s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 非血缘脐血移植治疗高危难治AML1-ETO阳性急性髓细胞白血病的疗效分析. 分析非血缘脐血移植（UCBT）治疗AML1-ETO+ 急性髓系白血病（AML）患者中的植入、移植物抗宿主病（GVHD）及生存等临床结果. 2010年7月-2018年4月，单中心进行单份UCBT治疗高危难治性AML1-ETO+ AML患者45例。对所有患者均采用清髓性预处理方案，应用环孢素A（CSA）联合吗替麦考酚酯（MMF）预防GVHD. 输注脐血总有核细胞（TNC）中位值为5.21（1.96-12.68）×10<sup>7</sup>/kg受者体重，CD34+细胞数为5.61（0.56-15.4）×10<sup>5</sup>/kg受者体重。42 d中性粒... | zh-cn |
pair_31418389 | To obtain induced pluripatent stem cells (iPSC) from peripheral blood mononucleated cells and further induce differentiation into mesenchymal stem cells (MSC), and to compare the biological characteristics of iPSC-derived MSC and other-derived MSC. Peripheral blood mononucleated cells were obtained and transduced with ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 诱导多能干细胞来源的间充质干细胞的生物学特性. 利用外周血单个核细胞获得诱导多能干细胞（iPSC）并进一步诱导分化为间充质干细胞(MSC)，观察iPSC来源MSC的生物学特性，并与其他来源MSC的相关生物学特性进行对比. 获取外周血单个核细胞并使用仙台病毒载体对其进行重编程因子的转导，鉴定其细胞形态和多能性因子的免疫荧光表达水平。对1株完成所有鉴定的iPSC进行MSC的诱导分化，并利用免疫组织化学和流式细胞术对其细胞形态、免疫表型进行鉴定。使用成脂、成骨培养液进行成脂成骨的诱导分化，以鉴定其分化能力。利用PCR鉴定其转录因子的表达，以系统阐明iPSC诱导分化所得的MSC的生物学特性. 外周血单个核细胞经过携带重编程因子的仙台病毒转染... | zh-cn |
pair_31418390 | To explore the role of bone marrow microenvironment(niche) in the development of acute myeloid leukemia (AML) and the effect of AML patients-derived MSC on the proliferation, cell cycle and immuno-phenotypes of HL-60 cells. The MSC derived from bone marrow of patients with newly diagnosed AML were isolated and co-cultu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 初诊急性髓系白血病患者来源的骨髓间充质干细胞调节HL-60细胞的增殖、细胞周期和免疫表型. 探讨急性髓系白血病(AML)患者的骨髓微环境在发病过程中的作用及AML患者间充质干细胞（MSC）对HL-60细胞的增殖、细胞周期和免疫表型的影响. 分离初诊AML患者骨髓MSC，将其和HL-60细胞共培养，以3H-TdR掺入法检测MSC对HL-60细胞增殖的影响，应用流式细胞术检测HL-60的细胞周期和免疫表型. 3H-TdR掺入法的结果表明，初诊AML患者骨髓MSC显著抑制HL-60增殖，并且具有良好的量效关系(r=0.998)。 细胞周期分析结果显示，MSC使HL-60细胞更多的阻滞在G<sub>0</sub>/G<sub>1</sub>... | zh-cn |
pair_31418391 | To explore the effect of bone morphogenetic protein 4(BMP4) on the cell cycle and apoptosis of hemaropoictic stem and progenitor cells (HSPC) in conditions of 5-fluorouracil (5-FU)-inducing bone marrow suppression and stress hemogenesis, and its possible mechanism. The C57BL transgenic mice with BMP4 overexpression wer... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 化疗抑制下骨髓BMP4对造血干/祖细胞周期、凋亡的调控及其机制. 探讨5-氟尿嘧啶（5-FU）诱导的骨髓抑制或应激造血条件下骨形态发生蛋白4（bone morphogenetic protein 4，BMP4）对造血干/祖细胞（HSPC）的周期、凋亡调控的作用及其相关机制. 设计构建BMP4过表达的C57BL/6转基因小鼠（transgenec group），选取周龄、性别、体重相匹配的野生型（WT）雌鼠为对照组，各实验重复3次。5-FU以150 mg/kg的剂量诱导骨髓抑制模型，提取骨髓有核细胞。通过c-kit/Sca-1荧光抗体双标HSPC，分别用Annexin V/PI和Ki-67/DAPI双染法观察其凋亡和细胞周期的变化。R... | zh-cn |
pair_31418392 | To explore the method of isolation, purification and differentiation of hematopoietic stem cells (HSCs) into dendritic cells (DC) in lung tissue of mouse, so as to provide theoretical basis and experimental methods for the study of hematopoietic stem cells in mouse lung tissue. Lung tissues of 4 male C57 mice were dige... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 小鼠肺组织内造血干细胞分离、纯化与诱导分化为树突细胞的实验研究. 探索小鼠肺组织内造血干细胞分离、纯化与诱导分化为树突细胞（dendriric cell，DC）的方法，为小鼠肺组织内造血干细胞的相关研究提供理论基础和实验方法. 4只雄性C57小鼠肺组织经I型胶原酶、I型DNA酶和淋巴细胞分离液消化、分离、纯化为单个核细胞，采用流式细胞仪鉴定和分选Lin<sup>-</sup>Sca-1<sup>+</sup>c-Kit<sup>+</sup>细胞即造血干细胞（HSC）。向所获得的HSC加入干细胞因子(SCF)和白介素(IL)-3促进细胞增殖。停用SCF和IL-3后，加入粒细胞-巨噬细胞集落刺激因子(GM-CSF)和IL-4将HSC诱... | zh-cn |
pair_31418393 | To study the influence of acute myeloid leukemia (AML) microenvironment on mesenchymal stem cells (MSCs). MSCs were isolated from the bone marrow of newly diagnosed AML patients (AML-MSCs) and were cultured. The morphology of MSC was observed by inverted microscopy, the immunophenotypes of MSC were detected by flow cyt... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_31418394 | To investigate the methods for verifying and comparing performance of HIV testing methods and procedure analysis in blood station laboratories so as to meet the requirements of ISO15189 accreditation. The performance of HIV test was verified by the automatic ELISA analyzer, the intra- and inter-assay precision was anal... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 血站实验室HIV检测性能验证的研究. 探讨血站实验室HIV检验方法和程序分析性能的验证与比对方法，以满足实验室ISO15189认可工作. 对全自动ELISA分析仪进行HIV检测性能验证，利用批内重复试验和批间重复试验进行分析内和分析间精密度评价。采用标准血清盘的结果和近2年内卫生部室间质评结果进行符合率验证。采用对已知含量的室内质控品进行连续稀释后检测的方法，进行检出限验证。采用检测1份已知全阴性标本、1份其他标志物阳性的HIV阴性标本、1份HIV强阳性标本和2份HIV弱阳性标本对仪器进行比对. 分析内和分析间精密度分别为5.12%和16.81%；血清盘检测符合率均为100%；卫生部反馈室间质评结果符合性均为100%；HIV检出限为... | zh-cn |
pair_31418395 | To improve the method for detecting the neutrophil CD64 (nCD64) index and to enhance the detection rate and accuracy of nCD64 index in patients with hematologic malignancies. The nCD64 index in peripheral blood of patients with hematologic malignancies combined with suspicious bacterial infection (255 cases-time) was d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_31418396 | To explore the clinical feature of liver injury in patients with hemophagocytic syndrome (HPS). The clinical data of 92 patients with HPS in our hospital were analyzed retrospectively, and the characteristics of hepatic lesion and its relationship with prognosis in HPS patients were explored. 92 cases of HPS showed dif... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 噬血细胞综合征患者肝功能损害的临床特点分析. 研究噬血细胞综合征（hemophagocytic syndrome，HPS）患者肝功能损害的临床特点. 回顾性分析本院92例HPS患者肝功能损害相关的临床资料，探讨肝功能异常的特点及其和HPS患者生存的关系. 92例HPS患者均有不同程度的肝功能异常，以轻、中度损害为主。肝功能损害主要表现为乳酸脱氢酶（LDH，89.13％）和天门冬氨酸氨基转氨酶（AST，64.13％）明显升高，白蛋白（ALB，90.22％）显著下降，总胆红素升高以直接胆红素（DBIL，59.78％）为主，伴活化部分凝血活酶时间（APTT，76.09％）以及凝血酶原时间（PT，67.39％）的延长。风湿免疫组患者的ALB... | zh-cn |
pair_31418398 | Abstract Double-hit lymphoma (DHL) is a high-grade B-cell lymphoma with MYC and BCL-2/BCL-6 rearrangement, which is a invasive disease with a poor prognosis. FISH is the most important diagnostic method. There is no standard protocol for this disease yet. New therapeutic approaches including targeted therapy，checkpoin... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 双打击淋巴瘤诊断和治疗最新研究进展. 双打击淋巴瘤（double hit lymphoma DHL）是具有MYC和BCL-2/BCL-6基因重排的高级别B细胞淋巴瘤。该病患者的预后较差。要明确诊断DHL须完善FISH检查，而该检查在临床上尚未广泛开展，造成了一定量的漏诊。目前DHL仍以化疗为主，大多数患者疗效不佳，国际上对DHL治疗积极进行了探索，免疫疗法和相关途径的靶向药物治疗为DHL的治疗提供了新方向。本文就近年来DHL 的诊断和治疗的最新研究进展作一综述。. | zh-cn |
pair_31418399 | Abstract Chimeric antigen receptor-T cell(CAR-T) is a kind of genetically engineered T cells that can express tumor antigen-specific receptors on its surface, and the modified T cells can be used for cancer therapy through targeting malignant tumor cells with its specific receptor and killing tumor cells with its cyto... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 嵌合抗原受体T细胞治疗复发难治性多发性骨髓瘤的最新研究进展. 嵌合抗原受体T细胞（chimeric antigen receptor-T cells，CAR-T）是用基因工程的方法进行人工改造的T细胞。CAR-T细胞可以表达肿瘤抗原特异性受体，该受体能特异性地识别并结合恶性肿瘤细胞，CAR-T细胞被激活时，可利用细胞毒性作用杀伤肿瘤细胞，该方法已在临床上成功地运用于治疗多种血液系统恶性肿瘤，如ALL、CLL、NHL、MM等。CAR-T细胞常被用于治疗复发难治性多发性骨髓瘤（RRMM），已有许多研究机构报道了其在临床试验中取得的成果，该方法提高了MM患者的治疗效果并延长生存时间。本文从多种CAR-T的疗效、不良反应、机遇与挑战等方面进... | zh-cn |
pair_31418400 | Abstract Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease, although the ITP pathogenesis is completely unknown, but in terms of the current view, the immune tolerance is main reason for the onset of ITP. In recent years, more and more immune cell subsets, cytokines and the new approacher wer... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 原发免疫性血小板减少症的免疫机制研究进展. 免疫性血小板减少症（ITP）是一种获得性自身免疫性出血性疾病，虽然ITP病因至今未明，但就目前的观点而言，免疫失耐受为ITP发病的主要原因。除却经典的免疫发病机制外，近年来更多的免疫细胞亚群、细胞因子及新的作用途径被发现与ITP的发生密切相关，包括去唾液酸化、B细胞激活因子作用、调节性B细胞功能异常、Th1/Th2平衡漂移、CD4<sup>+</sup>CD25<sup>+</sup>T细胞功能缺陷、IL-23/Th17途径调控等。本文就此对ITP免疫发病机制的最新研究进展作一综述，为更加深入认识ITP发病机制及研究方向提供理论依据。. | zh-cn |
pair_31418402 | Abstract Myelodysplastic syndromes (MDS) represent a clonal hematopoietic stem cell disorder characterized by morphologic features of dyspoiesis, high risk of transformation from MDS into AML. Allogeneic hematopoietic stem-cell transplantation is the only curative therapy for MDS, but the failure rate of transplantati... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基因突变对造血干细胞移植后MDS患者预后评估作用的研究进展. 骨髓增生异常综合征（MDS）是一组起源于造血干细胞，以血细胞病态造血，高风险向急性髓系白血病转化为特征的难治性血细胞质、量异常的异质性疾病。造血干细胞移植是治愈该病的唯一方法，但是其复发及相关并发症所致的移植失败率很高。高通量测序技术的发展较全面地揭示了MDS的基因突变谱系，发现80%以上的MDS患者至少伴有1种基因突变，且突变基因类型与MDS患者的临床表型及预后关系密切。本文就MDS相关突变基因、突变基因对MDS患者的预后及突变对移植后患者预后的影响等研究最新进展进行综述，以便更好地建立相关预测模型及指导治疗。. | zh-cn |
pair_31418404 | Abstract Demethylating agents (HMAs) hold an important status in therapy for elderly acute myeloid leukemia, who are not eligible for intensive chemotherapy (ICT). Beyond the edge of monotherapy, domestic and foreign scholars have carried out a lot of studies on combination strategies, such as HMAs with low-intensity... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 去甲基化药物在老年急性髓系白血病中的联合治疗进展. 去甲基化药物在不适合高强度化疗的老年急性髓系白血病患者的治疗中占据重要地位，除单药应用外，国内外学者还尝试了很多联合用药研究，与低强度化疗（如CAG方案）、靶向治疗（如BCL-2抑制剂）、免疫治疗（如PD-1/PD-L1抑制剂）、其他表观遗传学药物（如组蛋白去乙酰化酶抑制剂和异柠檬酸脱氢酶抑制剂）等联合，这些研究均取得疗效，并探讨联合应用的机制。本文对去甲基化药物联合用药的最新研究成果作一综述. | zh-cn |
pair_31418405 | Abstract Numerous studies have confirmed that abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway is one of the most common induction mechanisms of T-ALL. In recent years, many literature report that multiple abnormally expressed microRNAs (miRNAs) can participate i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | PI3K/AKT信号通路及miRNA在急性T淋巴细胞白血病中作用的研究进展. 有大量研究证实，磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（AKT）信号通路的异常激活是T-ALL最常见的诱发机制之一。近年来的文献报道，多种异常表达的微小RNA（miRNA）可通过调节PI3K/AKT信号通路参与T-ALL的发生发展，如miR-19和miR181a的过表达、miR-26b和miR-29a的低表达均可激活PI3K/AKT信号通路，导致T-ALL的发生并诱导其对化疗药物耐药。除靶向PI3K/AKT信号通路的抑制剂和中药外，调节相应miRNA的表达也可能是一种治疗T-ALL的潜在方案。本文对参与T-ALL发生发展的PI3K/AKT信号通路机制、... | zh-cn |
pair_31418406 | Abstract Tumor xenograft model (PDTX) derived from leukemia patients is an animal model in which the leukemia cells or primary cell lines of patients are transplanted directly into immunodeficient mice.The emergence of nude mice and SCID mice opened early xenotransplantation, then the NSG, NOG mice and the improved mo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 白血病异种移植模型的应用研究进展. 白血病患者来源的肿瘤异种移植模型(PDTX) 是将患者白血病细胞或原代细胞系直接移植到免疫缺陷小鼠体内的动物模型。裸小鼠和SCID小鼠的出现开启了早期异种移植，随后的NSG、NOG小鼠及基于此的改进模型和人源化小鼠显著提高了移植成功率，新近出现的白血病LSC移植及基于iPSC技术衍生的患者来源诱导多能干细胞移植为白血病发生发展的认知提供了新的见解，而存在正常人淋巴造血重建的新型人源化小鼠模型为白血病细胞疗法及免疫治疗提供了新的平台。PDTX是当前研究白血病发病与耐药机制，新药开发及个体化治疗的重要平台。本文就近年来免疫缺陷鼠及其模型构建、模型应用等方面，介绍异种移植构建免疫缺陷鼠人白血病模型的最新... | zh-cn |
pair_31418485 | There is increasing pressure to use currently untapped resources in the deep sea, raising questions regarding ecosystem service trade-offs in these often unknown areas. We assessed the trade-offs between protection of cold-water coral reefs and economic activities, such as fisheries and petroleum extraction, through a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着对尚未开发的深海资源进行利用的压力与日俱增,这些不为人知的地区的生态系统服务利弊权衡问题也开始涌现。我们通过在挪威和爱尔兰进行代表性抽样调查, 评估了冷水珊瑚礁保护与渔业、石油开采等经济活动之间的利弊权衡。我们分别在研讨会和网络上开展了选择实验调查, 这两种方法在保护的偏好性等方面得到了相似结果。跨国家比较分析显示, 挪威和爱尔兰的公众愿意保护作为鱼类栖息地的珊瑚礁, 即使保护行动可能与深海开采及消费经济活动相冲突。为实现保护地面积的小幅增长和大幅增长, 人们平均来说分别愿意支付 341 和 424 挪威克朗, 在其它条件不变的情况下，愿意为鱼类重要栖息地的保护支付 880 挪威克朗。然而, 这些金额在个体和国家水平都存在很大差... | zh-cn |
pair_31418485 | There is increasing pressure to use currently untapped resources in the deep sea, raising questions regarding ecosystem service trade-offs in these often unknown areas. We assessed the trade-offs between protection of cold-water coral reefs and economic activities, such as fisheries and petroleum extraction, through a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Existe una creciente presión por el uso correcto de recursos NO EXPLOTADOS en los mares profundos, lo que genera preguntas con respecto a las compensaciones de los servicios ambientales en los ecosistemas de estas áreas comúnmente desconocidas. Evaluamos las compensaciones entre la protección de los arrecifes de coral ... | es |
pair_31418832 | Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative researc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La ricerca in psicoterapia è un’area di studio in rapida evoluzione che tende ad esplorare l’integrazione tra le condizioni interne ed esterne dell’esperienza individuale, l’interazione tra soggettivo ed oggettivo tanto quanto tra individuale e collettivo. Nell’articolo vengono affrontate domande relative ad una vision... | it |
pair_31418832 | Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative researc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 心理治疗研究是一个快速发展的领域, 它的目标是探索个体经验内在和外在状况的整合、主体与客体间以及个体与集体间的相互作用。这篇文章讨论的问题涉及心理治疗中更加整合的观点及定性的研究。作者介绍了来自维尔纽斯大学“人格心理动力研究中心”的一群研究者在进行心理治疗有效性研究时所发展出来的一些概念。这一研究团队的成员为具有博士学位的临床心理学家或是在维尔纽斯大学心理系在读的博士生。对治愈情节的主观理解, 以及作为治愈前提的深度发展是这些研究的主要任务。在研究者采用的诸多方法中, 还包括画出治愈时刻的图画, 以及来访者通过回忆而讲一个心理治疗的故事, 这些都作为研究所收集的数据。文章分析了两幅关于治愈时刻的绘画的案例, 以及一个治疗故事讲述的案... | zh-cn |
pair_31418832 | Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative researc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La recherche dans le domaine de la psychothérapie est un domaine d’étude en croissance rapide qui vise à étudier l’intégration des conditions intérieures et extérieures dans l’expérience d’une personne, l’interaction entre le subjectif et l’objectif, ainsi qu’entre l’individuel et le collectif. L’article aborde des que... | fr |
pair_31418832 | Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative researc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Psychotherapieforschung ist ein sich rasant entwickelndes Forschungsgebiet, das darauf abzielt, die Integration der inneren und äußeren Bedingungen einer individuellen Erfahrung, das Zusammenspiel von Subjektivem und Objektivem sowie von Individuellem und Kollektivem zu untersuchen. In diesem Beitrag werden Fragen disk... | de |
pair_31418832 | Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative researc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La investigación en psicoterapia es un área de estudio en creciente desarrollo cuyo objetivo es explorar la integración entre las condiciones internas y externas de la experiencia de un individuo, el inter-juego entre lo subjetivo y lo objetivo, así como entre lo individual y lo colectivo. Se plantean consideraciones r... | es |
pair_31418832 | Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative researc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Исследование в психотерапии - это быстро развивающая область знаний, задачи которой состоят в изучении интеграции внутренних и внешних условий индивидуального опыта, взаимодействия между субъективным и объективным, индивидуальным и коллективным. В статье обсуждаются вопросы, связанные с интегративным подходом и качеств... | ru |
pair_31418834 | This paper discusses the main features of Siberian identity formed throughout the historical development of Siberia under the influence of social, economic, geographical, climatic, and other factors. Siberian cultural identity is closely connected with the mythology and ancient religion of the indigenous peoples of Sib... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Questo articolo esamina i principali aspetti dell’identità siberiana formatisi nel corso dello sviluppo della Siberia sotto l’influenza di fattori sociali, economici, geografici, climatici ed altri. L’identità culturale siberiana è strettamente correlata alla mitologia ed all’antica religione della popolazione indigena... | it |
pair_31418834 | This paper discusses the main features of Siberian identity formed throughout the historical development of Siberia under the influence of social, economic, geographical, climatic, and other factors. Siberian cultural identity is closely connected with the mythology and ancient religion of the indigenous peoples of Sib... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 这篇文章讨论了在西伯利亚在社会、经济、地域、气候和其它因素影响下的历史发展中, 所构建起来西伯利亚人身份认同的主要特征。西伯利亚人的文化身份密切联系着其神话和原著民的古老宗教--即萨满教, 其仪式、意象、象征和教义常在来访者的梦中呈现。作者对西伯利亚的历史与文化进行了深层研究之后, 阐述了一个无家可归情结, 它根植在一个深度的集体创伤中, 并在人们的心灵中留下了印记。文章呈现了三个案例, 一方面展示了文化情结和集体创伤间的关系, 另一方面展示了个体情结和个体创伤。作者的心理治疗实践显示, 来访者对其历史和文化的觉察让他们更明了他们伤痛的意义和来源, 因此帮助他们找到自己的自性化之路, 而不是活在来自他们祖先的代际创伤中。. | zh-cn |
pair_31418834 | This paper discusses the main features of Siberian identity formed throughout the historical development of Siberia under the influence of social, economic, geographical, climatic, and other factors. Siberian cultural identity is closely connected with the mythology and ancient religion of the indigenous peoples of Sib... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cet article étudie les caractéristiques principales de l’identité Sibérienne formée au cours du développement historique de la Sibérie sous l’influence de facteurs sociaux, économiques, géographiques, climatiques et autres. L’identité culturelle Sibérienne est intimement liée à la mythologie et la religion ancienne des... | fr |
pair_31418834 | This paper discusses the main features of Siberian identity formed throughout the historical development of Siberia under the influence of social, economic, geographical, climatic, and other factors. Siberian cultural identity is closely connected with the mythology and ancient religion of the indigenous peoples of Sib... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | In diesem Artikel werden die Hauptmerkmale der sibirischen Identität erörtert, wie sie sich während der historischen Entwicklung Sibiriens unter dem Einfluß sozialer, wirtschaftlicher, geographischer, klimatischer und anderer Faktoren gebildet hat. Die sibirische kulturelle Identität ist eng mit der Mythologie und der ... | de |
pair_31418834 | This paper discusses the main features of Siberian identity formed throughout the historical development of Siberia under the influence of social, economic, geographical, climatic, and other factors. Siberian cultural identity is closely connected with the mythology and ancient religion of the indigenous peoples of Sib... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El presente trabajo da cuenta de los rasgos principales de la identidad Siberiana formada a través del desarrollo histórico de Siberia bajo la influencia de factores sociales, económicos, geográficos, climáticos y otros. La identidad cultural Siberiana está conectada a la mitología y a la religión antigua de los pueblo... | es |
pair_31418834 | This paper discusses the main features of Siberian identity formed throughout the historical development of Siberia under the influence of social, economic, geographical, climatic, and other factors. Siberian cultural identity is closely connected with the mythology and ancient religion of the indigenous peoples of Sib... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | В статье исследуются основные черты сибирской идентичности, сформировавшиеся в ходе исторического развития Сибири под влиянием социальных, экономических, географических, климатических и других факторов. Сибирская культурная идентичность тесно связана с мифологией и древними верованиями коренных жителей Сибири - шаманиз... | ru |
pair_31418836 | The paper's central focus is on the usefulness or not of taking established and well-tried and tested models of training into cultures with different social, political and clinical attitudes. Beginning with the author's description of necessary changes introduced to ensure the revival of her own institute, the Society ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’articolo si focalizza sull’utilità o meno dell’importare modelli di formazione consolidati e testati all’interno di culture con diverse attitudini sociali, politiche e cliniche. Iniziando con la descrizione dell’Autrice dei necessari cambiamenti introdotti per garantire il rilancio del proprio istituto, la Società di... | it |
pair_31418836 | The paper's central focus is on the usefulness or not of taking established and well-tried and tested models of training into cultures with different social, political and clinical attitudes. Beginning with the author's description of necessary changes introduced to ensure the revival of her own institute, the Society ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 文章的核心关注点是:对不同社会、政治、临床态度的文化中输入训练时的获益之处, 或者说关注的是如何在输入训练时不去用已经建构好的, 被反复实践试验的训练模型。作者先描述了那些为了让她的机构 (即分析心理学学会)可以保有新生力而作出的必要改变, 然后探索了IAAP在多个国家独立运行的训练, 即“行者项目”, 多方面的相关问题。这个项目中, 当分析师、教师、督导到访其它国家, 并提供他们的专业时, 可能会经历到与他们分析性态度不一致的冲突, 这些冲突不仅仅来自于他们所训练的人, 也来自他们自己内在。. | zh-cn |
pair_31418836 | The paper's central focus is on the usefulness or not of taking established and well-tried and tested models of training into cultures with different social, political and clinical attitudes. Beginning with the author's description of necessary changes introduced to ensure the revival of her own institute, the Society ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’accent central de cet article est la question de savoir s’il est heureux ou non d’importer des modèles de formation établis et qui ont fait leurs preuves dans des cultures qui ont des attitudes cliniques, sociales et politiques différentes. Commençant par la description par l’auteur de changements nécessaires introdu... | fr |
pair_31418836 | The paper's central focus is on the usefulness or not of taking established and well-tried and tested models of training into cultures with different social, political and clinical attitudes. Beginning with the author's description of necessary changes introduced to ensure the revival of her own institute, the Society ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Das Hauptaugenmerk des Beitrages gilt der Zweckmäßigkeit oder Nichtzweckmäßigkeit etablierter und bewährter Ausbildungsmodelle in Kulturen mit unterschiedlichen sozialen, politischen und klinischen Einstellungen. Beginnend mit den Schilderung der notwendigen Veränderungen, die getroffen wurden, um die Wiederbelebung ih... | de |
pair_31418836 | The paper's central focus is on the usefulness or not of taking established and well-tried and tested models of training into cultures with different social, political and clinical attitudes. Beginning with the author's description of necessary changes introduced to ensure the revival of her own institute, the Society ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El foco central del artículo es sobre la utilidad o no, de llevar modelos de formación establecidos, y bien probados y testeados, a culturas con diferentes actitudes sociales, políticas y clínicas. Comenzando con la descripción de los cambios necesarios introducidos para asegurar la renovación de su propio instituto, l... | es |
pair_31418836 | The paper's central focus is on the usefulness or not of taking established and well-tried and tested models of training into cultures with different social, political and clinical attitudes. Beginning with the author's description of necessary changes introduced to ensure the revival of her own institute, the Society ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Внимание статьи обращено на полезность (или бесполезность) использования существующих хорошо апробированных тренинговых моделей в культурах с иными социальными, политическими и клиническими установками. Автор начинает с описания необходимых изменений, которые были внесены и оживили ее собственный институт the Society o... | ru |
pair_31418843 | In this paper, the Bluebeard story is used to highlight mechanisms underlying an individual analytic case and some cultural phenomena from a Jungian perspective. I describe a patient whose psyche was dissociated into a tormenting monstrous figure and a regressed childish self, which Kalsched explains as activation of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | In questo articolo, la storia di Barbablù è utilizzata per evidenziare meccanismi sottostanti un caso analitico e alcuni fenomeni culturali da una prospettiva junghiana. Descrivo una paziente la cui psiche era dissociata in una figura mostruosa e crudele ed in un sé infantile regredito, che Kalsched descrive come attiv... | it |
pair_31418843 | In this paper, the Bluebeard story is used to highlight mechanisms underlying an individual analytic case and some cultural phenomena from a Jungian perspective. I describe a patient whose psyche was dissociated into a tormenting monstrous figure and a regressed childish self, which Kalsched explains as activation of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 文中用蓝胡子的故事来强调在一个个体分析案例中发生的基本的心理机制, 以及从荣格学派的角度强调了一些文化现象。作者描述了一个病人, 其心灵分裂为一个折磨人的可怕人物和一个退行的孩子气的自我, 即卡尔斯切德所说的被激活的原型防御系统。作为她的分析师, 我必须要受得住这位病人迫害性的内在客体的攻击, 她把这个客体与蓝胡子联系起来, 代表了残酷的谋杀性。在文化层面, 蓝胡子属于极权主义客体的概念 (Sebek 1996), 是俄罗斯文化情结中自大狂的极点。. | zh-cn |
pair_31418843 | In this paper, the Bluebeard story is used to highlight mechanisms underlying an individual analytic case and some cultural phenomena from a Jungian perspective. I describe a patient whose psyche was dissociated into a tormenting monstrous figure and a regressed childish self, which Kalsched explains as activation of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Dans cet article, l’histoire de Barbe Bleue est utilisée afin de souligner les mécanismes à l’œuvre dans un cas analytique et quelques phénomènes culturels à partir d’une perspective Jungienne. Je décris un patient dont la psyché a été dissociée en un personnage monstrueux et torturant, et en un soi infantile régressé,... | fr |
pair_31418843 | In this paper, the Bluebeard story is used to highlight mechanisms underlying an individual analytic case and some cultural phenomena from a Jungian perspective. I describe a patient whose psyche was dissociated into a tormenting monstrous figure and a regressed childish self, which Kalsched explains as activation of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | In diesem Aufsatz wird aus einer Jungianischen Perspektive die Blaubartgeschichte dazu verwendet, Mechanismen aufzuzeigen, die einem individuellen analytischen Fall wie auch einigen kulturellen Phänomenen zugrunde liegen. Ich beschreibe einen Patienten, dessen Psyche in eine quälende monströse Gestalt und ein regredier... | de |
pair_31418843 | In this paper, the Bluebeard story is used to highlight mechanisms underlying an individual analytic case and some cultural phenomena from a Jungian perspective. I describe a patient whose psyche was dissociated into a tormenting monstrous figure and a regressed childish self, which Kalsched explains as activation of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | En el presente trabajo, la historia de Barba Azul es utilizada para esclarecer los mecanismos que subyacen a un caso analítico individual, y ciertos fenómenos culturales desde una perspectiva Junguiana. Describo a un paciente cuya psique fue disociada entre una figura monstruosa y atormentadora, y un self infantil regr... | es |
pair_31418843 | In this paper, the Bluebeard story is used to highlight mechanisms underlying an individual analytic case and some cultural phenomena from a Jungian perspective. I describe a patient whose psyche was dissociated into a tormenting monstrous figure and a regressed childish self, which Kalsched explains as activation of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | В данной статье история Синей Бороды использована для того, чтобы осветить с юнгианской точки зрения механизмы, лежащие в основе индивидуального аналитического случая и некоторых культурных феноменов. Я описываю пациентку, чья психика раскололась на мучающего монстра и регрессировавшее детское я. Калшед объясняет подоб... | ru |
pair_31418844 | This paper outlines the difference between healthy and unhealthy forms of dissociation following, and in response to, traumatic experience, in particular the experience of refugees, calling on 30 years' experience in working with refugees in voluntary and public sectors, including 20 years at the Refugee Therapy Centre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Questo articolo delinea la differenza tra forme di dissociazione sane e malate a seguito, ed in risposta, a l’esperienza traumatica, in particolare l’esperienza dei rifugiati, facendo riferimento a 30 anni di esperienza di lavoro con essi, sia nel settore pubblico che nel volontariato, compresi 20 anni presso il Refuge... | it |
pair_31418844 | This paper outlines the difference between healthy and unhealthy forms of dissociation following, and in response to, traumatic experience, in particular the experience of refugees, calling on 30 years' experience in working with refugees in voluntary and public sectors, including 20 years at the Refugee Therapy Centre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 这篇文章结合了作者30年间作为志愿者和公共机关工作者与难民工作的经验, 以及20年来在伦敦难民治疗中心的经验, 来概述健康与不健康的隔离间的差别, 及其与创伤的关系, 文章特别关注了难民的经验。文章把隔离与压抑做了区分, 分析了难民的移置和其特别处境相关的创伤经验, 特别是与他们的丧失有关的经验。文章描述了四种关键的弹性特征:“心理空间”, “自我感”, 对“倾听的他人”的使用, “健康的隔离/弹性”。文章插叙了两个片段用来区分健康与不健康的隔离。. | zh-cn |
pair_31418844 | This paper outlines the difference between healthy and unhealthy forms of dissociation following, and in response to, traumatic experience, in particular the experience of refugees, calling on 30 years' experience in working with refugees in voluntary and public sectors, including 20 years at the Refugee Therapy Centre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cet article souligne la différence entre des formes saines et des formes pathologiques de dissociation, qui surviennent à la suite d’expériences traumatiques et en réponse à ces expériences. L’article s’appuie en particulier sur l’expérience de réfugiés ainsi que l’expérience de trente années de travail de l’auteur aup... | fr |
pair_31418844 | This paper outlines the difference between healthy and unhealthy forms of dissociation following, and in response to, traumatic experience, in particular the experience of refugees, calling on 30 years' experience in working with refugees in voluntary and public sectors, including 20 years at the Refugee Therapy Centre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | In diesem Beitrag wird der Unterschied zwischen gesunden und ungesunden Formen der Dissoziation nach und als Reaktion auf traumatische Erfahrungen, insbesondere die Erfahrungen von Flüchtlingen, skizziert. Dabei wird auf 30 Jahre Erfahrung in der Arbeit mit Flüchtlingen im freiwilligen und öffentlichen Sektor zurückgeg... | de |
pair_31418844 | This paper outlines the difference between healthy and unhealthy forms of dissociation following, and in response to, traumatic experience, in particular the experience of refugees, calling on 30 years' experience in working with refugees in voluntary and public sectors, including 20 years at the Refugee Therapy Centre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El presente trabajo da cuenta de la diferencia entre formas saludables y no saludables de disociación, en respuesta a experiencias traumáticas, en particular, la experiencia de los refugiados; a partir de 30 años de experiencia trabajando con refugiados en sectores públicos y privados, incluyendo 20 años en el Centro d... | es |
pair_31418844 | This paper outlines the difference between healthy and unhealthy forms of dissociation following, and in response to, traumatic experience, in particular the experience of refugees, calling on 30 years' experience in working with refugees in voluntary and public sectors, including 20 years at the Refugee Therapy Centre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | В статье описаны различия между здоровыми и нездоровыми формами диссоциации как ответной реакции на травматический опыт. Особое внимание уделено опыту беженцев, так как автор проработала 30 лет в добровольческих и общественных организациях помощи беженцам, в том числе в Терапевтическом Центре для беженцев в Лондоне. Пр... | ru |
pair_31418846 | Beginning with the story of Bluebeard, the author considers how traumatic overwhelm can occur in everyday childhood situations of a psychically murderous quality; for example, a nanny's totalitarian regime may be invisible to parents ruled by collective social and cultural norms. A child who is remote from mother and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Iniziando con la storia di Barbablù, l’autrice considera come una inondazione traumatica, con una qualità potenzialmente omicida, possa avvenire in situazioni quotidiane dell’infanzia; per esempio, il regime totalitario di una bambinaia può essere invisibile a genitori guidati da norme sociali e culturali. Un bambino d... | it |
pair_31418846 | Beginning with the story of Bluebeard, the author considers how traumatic overwhelm can occur in everyday childhood situations of a psychically murderous quality; for example, a nanny's totalitarian regime may be invisible to parents ruled by collective social and cultural norms. A child who is remote from mother and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 文章以蓝胡子的故事作为开始, 作者讨论了创伤性的压制可以出现在童年日常情境中, 表现为心理谋杀的特性。比如, 在集体社会和文化规范统治之下的父母可能看不出保姆所持有的极权主义状态。远离母亲并把父亲理想化的孩子, 体现了一个有力的父权体系, 它会维持对婚姻天真的依赖, 无法应对人类攻击性的事实。文章描述了和一位女性的分析性工作, 她重复性地经历了崩溃的状态, 她需要放弃一个脆弱的、被社会建构的身份, 以便于建构她自己的真实取向。. | zh-cn |
pair_31418846 | Beginning with the story of Bluebeard, the author considers how traumatic overwhelm can occur in everyday childhood situations of a psychically murderous quality; for example, a nanny's totalitarian regime may be invisible to parents ruled by collective social and cultural norms. A child who is remote from mother and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Prenant pour point de départ l’histoire de Barbe Bleue, l’auteur examine comment le débordement traumatique peut se produire dans l’enfance dans des situations de tous les jours qui ont une qualité psychique meurtrière. Par exemple, le régime totalitaire d’une assistante maternelle (nourrice) peut être invisible aux ye... | fr |
pair_31418846 | Beginning with the story of Bluebeard, the author considers how traumatic overwhelm can occur in everyday childhood situations of a psychically murderous quality; for example, a nanny's totalitarian regime may be invisible to parents ruled by collective social and cultural norms. A child who is remote from mother and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Ausgehend von der Geschichte von Blaubart betrachtet die Autorin, wie traumatische Überwältigungen von psychisch mörderischer Qualität in alltäglichen Situationen der Kindheit auftreten können. Zum Beispiel mag das totalitaristische Regime einer Kinderfrau für Eltern unsichtbar sein, die ihrerseits von kollektiven sozi... | de |
pair_31418846 | Beginning with the story of Bluebeard, the author considers how traumatic overwhelm can occur in everyday childhood situations of a psychically murderous quality; for example, a nanny's totalitarian regime may be invisible to parents ruled by collective social and cultural norms. A child who is remote from mother and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Comenzando con la historia de Barba Azul, la autora considera cómo una devastación traumática puede ocurrir en situaciones cotidianas de infancias con cualidades de asesinato psíquico; por ejemplo, el régimen totalitario de una abuelita puede resultar invisible a los padres regulados por normas colectivas sociales y cu... | es |
pair_31418846 | Beginning with the story of Bluebeard, the author considers how traumatic overwhelm can occur in everyday childhood situations of a psychically murderous quality; for example, a nanny's totalitarian regime may be invisible to parents ruled by collective social and cultural norms. A child who is remote from mother and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Начиная со сказки про Синюю Бороду, автор рассматривает, как травматическая охваченность убийственного для психики качества может случиться в повседневной жизни ребенка. Например, тоталитарный режим, введенный няней и невидимый для родителей. Ребенок, который удален от матери и идеализирует отца - носителя мощной патри... | ru |
pair_31418848 | The research into the phenomenon of cultural trauma is growing as the effects of historical transformations are recognized and analysed. The concept of cultural trauma and the analytic concept of the cultural complex is a suitable theoretical approach for this research. The Lithuanian experience of cultural trauma afte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La ricerca sul fenomeno del trauma culturale cresce man mano che gli effetti delle trasformazioni storiche vengono riconosciuti ed analizzati. Il concetto di trauma culturale ed il concetto analitico del complesso culturale sono degli adeguati approcci teorici per questa ricerca. L’esperienza lituana del trauma cultura... | it |
pair_31418848 | The research into the phenomenon of cultural trauma is growing as the effects of historical transformations are recognized and analysed. The concept of cultural trauma and the analytic concept of the cultural complex is a suitable theoretical approach for this research. The Lithuanian experience of cultural trauma afte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着人们越多地对历史性转变效应的觉察和分析, 关于文化创伤现象的研究也越发增多。文化创伤的概念 和分析心理学关于文化情结的概念 是适合于这类研究的理论取向。立陶宛在历史性转变之后所经历的文化创伤, 呈现了在应付创伤时, 社会与个体因素相互作用的重要性。在维尔纽斯大学进行的关于心理创伤的学术研究显示, 经历过直接的政治性压迫的幸存者, 具有更强的创伤经验, 甚至会把创伤进行隔代的传递, 但这个群体似乎也在隔代之间传递了弹性。矛盾的是, 从长期的角度看, 受到直接压迫的受害者似乎比那些适应了这个制度的人更少地感受到痛苦, 对于他们的后代来说也是如此。关于文化创伤的克服的分析显示, 社会在逐步整合历史性的创伤经验, 尽管一个健康的文化身份... | zh-cn |
pair_31418848 | The research into the phenomenon of cultural trauma is growing as the effects of historical transformations are recognized and analysed. The concept of cultural trauma and the analytic concept of the cultural complex is a suitable theoretical approach for this research. The Lithuanian experience of cultural trauma afte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La recherche sur le phénomène du traumatisme culturel se développe alors que les effets des transformations historiques sont reconnues et analysées. Le concept de traumatisme culturel et le concept analytique du complexe culturel donnent un cadre théorique utile pour ce domaine d’études. L’expérience lithuanienne de tr... | fr |
pair_31418848 | The research into the phenomenon of cultural trauma is growing as the effects of historical transformations are recognized and analysed. The concept of cultural trauma and the analytic concept of the cultural complex is a suitable theoretical approach for this research. The Lithuanian experience of cultural trauma afte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Erforschung des Phänomens des kulturellen Traumas nimmt zu, je mehr die Auswirkungen historischer Veränderungen sichtbar und analysiert werden. Das Konzept des Kulturtraumas und das analytische Konzept des Kulturellen Komplexes bilden geeignete theoretische Ansätze für diese Forschung. Die litauische Erfahrung des ... | de |
pair_31418848 | The research into the phenomenon of cultural trauma is growing as the effects of historical transformations are recognized and analysed. The concept of cultural trauma and the analytic concept of the cultural complex is a suitable theoretical approach for this research. The Lithuanian experience of cultural trauma afte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Mientras los efectos sobre las transformaciones históricas y sociales están siendo reconocidas y analizadas, la investigación sobre el fenómeno del trauma cultural está creciendo. El concepto de trauma cultural y el concepto analítico de complejo cultural es un abordaje teórico apropiado para dicha investigación. La ex... | es |
pair_31418848 | The research into the phenomenon of cultural trauma is growing as the effects of historical transformations are recognized and analysed. The concept of cultural trauma and the analytic concept of the cultural complex is a suitable theoretical approach for this research. The Lithuanian experience of cultural trauma afte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Область исследований феномена культурной травмы растет по мере того, как распознаются и анализируются эффекты исторических перемен. Понятие культурной травмы и аналитическое понятие культурного комплекса - подходящие для этого исследования теоретические концепции. Литовский опыт культурной травмы исторических перемен п... | ru |
pair_31418921 | Conservation across human-dominated landscapes requires an understanding of the social and ecological factors driving outcomes. Studies that link conservation outcomes to social and ecological factors have examined temporally static patterns. However, there may be different social and ecological processes driving incre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在人类主导的景观中开展保护需要了解社会和生态因素对保护成效的影响。目前, 将保护成效与社会和生态因素相结合的研究已经分析了当下的静态格局。然而, 可能存在一些不同的社会和生态过程推动或阻碍着保护, 它们的影响要通过时序分析才能得到揭示。我们通过对夏威夷入侵物种南洋楹 (Falcataria moluccana) 的案例分析, 检验了社会因素与入侵范围的时空变化之间的关系。结果表明, 在超过七年的时间里, 南洋楹减少的速率相对于社会因素 (如建筑价值、土地私有或公有、土地是否用作私有者的主要住宅) 变化很大 (66-100%) , 而增加速率相对于这些因素变化却很小 (<0.1-3.6%) 。这些发现表明, 研究系统中社会因素与入侵的... | zh-cn |
pair_31418921 | Conservation across human-dominated landscapes requires an understanding of the social and ecological factors driving outcomes. Studies that link conservation outcomes to social and ecological factors have examined temporally static patterns. However, there may be different social and ecological processes driving incre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Uso de un Análisis Espacialmente Explícito y Dependiente del Tiempo para Entender cómo Influyen los Factores Sociales sobre los Resultados de la Conservación Resumen La conservación dentro de los paisajes dominados por humanos requiere de un entendimiento de los factores sociales y ecológicos que afectan los resultados... | es |
pair_33721943 | Diabetic kidney disease (DKD) has emerged as the primary cause of chronic kidney disease, posing a huge economic and social burden. Therefore, it is urgent to strengthen the prevention and treatment of DKD. However, due to the complex pathogenesis of DKD and the lack of specific and effective intervention targets, ther... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 糖尿病肾病（DKD）已成为我国慢性肾脏病的首要病因，造成了巨大的经济和社会负担，加强DKD防治已迫在眉睫。但由于DKD发病机制复杂，缺乏特异有效的干预靶点，在治疗方面目前尚无突破性进展，致使终末期DKD不断增多。本文对DKD治疗进展的几个关键节点进行述评，以期规范DKD的临床治疗，推动DKD研究进展，改善患者预后。. | zh-cn |
pair_33721944 | Chronic kidney disease (CKD) in diabetes mellitus includes diabetic kidney disease (DKD), non-diabetic kidney disease (NDKD) or a combination of NDKD and DKD. The clinical and renal pathological manifestations of DKD in type 1 diabetes are different from those in type 2 diabetes. Renal biopsy histopathology is the gold... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 糖尿病中的慢性肾脏病（CKD）包括糖尿病肾病（DKD）、非DKD（NDKD）或NDKD和DKD的组合。1型糖尿病中的DKD在临床和肾组织病理表现上均与2型糖尿病的DKD有所不同，肾穿刺组织病理学是鉴别DKD和NDKD的金标准。然而基于同样的病理诊断，DKD患者仍然可以因为分子生物学机制的个体化差异，导致病程的进展和预后各不相同，代谢组学、蛋白组学、转录组学以及人工智能为探索诊断和预测DKD进展的生物标志物带来了希望。. | zh-cn |
pair_33721945 | Diabetic kidney disease (DKD) is the most common chronic complication of diabetes mellitus and the major cause of end stage renal disease (ESRD). Prediction, early diagnosis and evaluation of disease progression are crucial to improve the prognosis of DKD. Estimated glomerular filtration rate (GFR) and urinary albumin ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 糖尿病肾病（DKD）是糖尿病最常见的慢性并发症，是终末期肾脏病（ESRD）的主要病因。DKD的预警、早期诊断和评估疾病进展对于改善预后至关重要。估算肾小球滤过率（eGFR）和尿白蛋白排泄率（AER）是DKD的主要诊断依据，但灵敏度和特异度存在不足。近年来，DKD新型生物标志物的价值逐渐受到重视。本文对近年来DKD新型生物标志物的临床研究进行评述，为DKD临床诊断和预后评估提供参考。. | zh-cn |
pair_33721946 | The incidence and mortality of pancreatic cancer are increasing year by year worldwide, but the prevention and treatment effect is far from satisfactory. Surgical resection remains the main treatment for pancreatic cancer, but the advantages and disadvantages of surgery are clear. How to avoid the disadvantages and max... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胰腺癌在全球范围内发病率和死亡率逐年增高，但防治效果仍不理想。手术切除是胰腺癌的主要治疗方式，但胰腺癌手术利弊分明。如何规避手术的弊，同时把利发挥到极致，使患者获益最大化应该是判断胰腺癌手术成功与否的主要标准。要实现胰腺癌手术的成功，围手术期必须关注肿瘤、宿主和团队的综合因素，尤其要充分认识TNM分期的局限性和重视规范化多学科诊疗模式（MDT）指导下的个体化综合诊治方案，以患者获得长期生存为终极目标，做一名合格的肿瘤外科医生。. | zh-cn |
pair_33721947 | In recent years, more and more attention has been paid on the role of neoadjuvant therapy in the comprehensive treatment of pancreatic cancer. There is increasing evidence indicates that neoadjuvant therapy improves the R0 resection rate and patient's prognosis. However, the indication, therapy selection and efficacy e... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年来，新辅助治疗在胰腺癌综合治疗中的作用日益受到重视。越来越多的证据表明，新辅助治疗有助于提高根治性（R0）切除率并改善患者预后。但目前新辅助治疗在胰腺癌患者中的应用指征、方案选择、疗效评估等仍有较大争议，临床应用尚不十分成熟。本文基于胰腺癌新辅助治疗的最新研究进展，分析胰腺癌新辅助治疗的临床实施难点，探讨科学合理的胰腺癌新辅助治疗模式。. | zh-cn |
pair_33721948 | Pancreatic cancer is one of the most malignant digestive tract tumors with a 5-year survival rate of less than 10%. Surgery remains the basis of long-term survival of pancreatic cancer patients. With the progress of chemotherapy, neoadjuvant therapy has been gradually carried out in pancreatic cancer. There are more an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胰腺癌是恶性程度最高的消化道肿瘤之一，其5年生存率仍然不足10%。手术是胰腺癌长期生存的基础。随着化疗方案的进步，新辅助治疗逐步在胰腺癌中得到开展。关于新辅助治疗对胰腺癌围手术期并发症影响的研究日益增多，但不同研究的结果并不一致。本研究回顾性分析了近年来胰腺癌新辅助治疗的相关研究，探讨了一些关键因素对围手术期并发症的影响。. | zh-cn |
pair_33721949 | Pancreatic cancer is considered to be the most malignant digestive tract tumor due to its high invasiveness, metastasis and recurrence rate. In recent years, neoadjuvant therapy has brought new insights to the treatment of pancreatic cancer. To date, the value of neoadjuvant therapy in pancreatic cancer has been widely... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胰腺癌因具有高侵袭性、高转移性、高复发率等特点被认为是恶性程度极高的消化道肿瘤。近年来新辅助治疗给胰腺癌的治疗带来了新的曙光，如今新辅助治疗在胰腺癌的价值已被广泛认可，但缺乏特异性方案，各类方案孰优孰劣尚无定论，可联合影像学、功能学和生物学标记物评估新辅助治疗的效果。. | zh-cn |
pair_33721950 | Pancreatic cancer has a high degree of malignancy, with a poor prognosis. Although surgical resection remains the only way to cure pancreatic cancer at present, the treatment mode has changed from 'surgery priority' to 'multidisciplinary cooperation' with the development of adjuvant therapy. Neoadjuvant therapy has bee... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胰腺癌恶性程度较高、预后较差。虽然手术切除仍是目前唯一能够治愈胰腺癌的方法，但伴随着胰腺癌辅助治疗的进展，其治疗模式已由“手术优先”向“多学科协作”转变。新辅助治疗已被证实可提高交界性可切除和局部进展期胰腺癌的R0切除率并改善患者预后，这些患者应给予新辅助治疗已成共识，但胰腺癌新辅助化疗方案的选择、放射治疗的地位、新辅助治疗后影像学与病理学评估等方面仍存较大争议。. | zh-cn |
pair_33721955 | Glaucoma is the leading cause of irreversible blindness worldwide. The Chinese Glaucoma Guidelines (2020) formulated important references and suggestions for the treatment of glaucoma, based on the basic national condition of China and considering the latest global progress. To fulfill their guiding effect on clinical ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 青光眼是全球首位不可逆性致盲眼病。《中国青光眼指南（2020年）》（以下简称《指南》）基于我国基本国情，结合了国内外最新研究进展，可为我国青光眼临床诊疗工作提供重要参考和建议。眼科界应对《指南》加大宣传和推广力度，拓展其传播渠道和覆盖范围，以期充分发挥《指南》对临床工作的指导作用；还应注重对《指南》进行质量评价和后效评价，在临床工作中检验《指南》的可靠性和适用性，推动青光眼循证实践；同时应不断积累和反馈证据，以促进《指南》更新和完善，从而构建良好的证据生态系统，以期不断有效助力我国青光眼临床诊疗水平提高。<i>（中华眼科杂志，2021，57：161-165）</i>. | zh-cn |
pair_33721956 | Primary glaucoma with cataract is a common eye disease in China, and surgery is the main treatment. With the continuous advance of medical technology, the choice of surgical methods is controversial, and there is still a lack of consensus with general guiding significance in China. In order to standardize the clinical ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 合并白内障的原发性青光眼作为我国比较常见的眼部疾病，手术是其主要的治疗方法。随着医疗技术的不断进步，其手术方式的选择出现较大争议，国内尚缺乏具有普遍指导意义的共识性意见。为规范临床治疗工作，中华医学会眼科学分会青光眼学组经过认真讨论，结合临床实践经验制定本共识，对具有白内障手术指征的不同类型、不同时期的原发性青光眼的手术方式及围手术期和随访的管理等提出指导性意见。<i>（中华眼科杂志，2021，57：166-170）</i>. | zh-cn |
pair_33721957 | Demyelinating optic neuritis (DON) is an inflammatory demyelinating disease of the central nervous system, which can lead to visual loss in young adults as a major factor. The key points concerned by neuro-ophthalmologists are to reduce the rate of recurrence and improve the prognosis in the course of diagnosis and tre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 脱髓鞘性视神经炎（DON）是主要累及视神经的中枢神经系统炎性脱髓鞘疾病。准确诊断、降低复发率、改善预后一直是临床诊疗过程中关注的重点。随着有关DON临床诊断标志物、疾病分型及不同亚型治疗研究的深入，越来越多的临床证据不断涌现，迫切需要及时制定DON的诊断和治疗循证指南，指导临床进一步规范开展工作。为此中华医学会眼科学分会神经眼科学组联合兰州大学循证医学中心/世界卫生组织指南实施与知识转化合作中心，按照循证指南制定的方法和步骤，成立指南指导委员会、指南共识专家组和指南外审专家组以及指南制定工作组，通过调研临床一线神经眼科医师、眼科医师及神经内科医师，收集并整理临床关注问题，全面检索和系统评价国内外相关研究证据，制定新的系统评价，组织召... | zh-cn |
pair_33721963 | The study aimed to introduce a new analysis method of 24-hour intraocular pressure (IOP) and to propose the concept of overall IOP. Data of 24-hour IOP of a patient with a confirmed diagnosis of normal tension glaucoma was selected. Based on the present indexes including peak IOP, trough IOP, maximum difference, and me... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 介绍一种新的24 h眼压数据分析方法，并提出全眼压的概念。选取1例确诊正常眼压性青光眼患者的24 h眼压数据，在原有指标眼压峰值、谷值、最大差值、平均值的基础上，提出主体眼压、主体眼压时长、升压速率等指标，绘制雷达图，计算得出全眼压的值。全眼压值=眼压值分布（各分区的眼压值×相应时长的总和）×眼压波动（标准差）×眼压上升速率/100。并通过2次眼压的数据对比，分析新的眼压指标的优势。全眼压概念的提出，把对眼压的描述从单一静态扩展到了全面动态，使24 h眼压监测结果的分析更深入细致。<i>（中华眼科杂志，2021，57：228-231）</i>. | zh-cn |
pair_33721964 | By reviewing the recent articles regarding the ocular side effect of tamoxifen when treating breast cancer and glioma, this article summarized the incidence and the potential mechanism of the side effects of tamoxifen, and the specific ocular toxicity including keratopathy, cataract, retinopathy, optic neuropathy. This... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本文回顾总结了近年来他莫昔芬应用于乳腺癌、神经胶质瘤治疗时出现的相关眼部病变的文献，将他莫昔芬导致眼部病变出现的发生率、发病机制、相关眼部病变特征性表现（角膜病变、白内障、视网膜病变、视神经病变以及其他一些少见病变）进行综述，为眼科医师对他莫昔芬眼部病变的识别和眼部病变的监测提供指导。<i>（中华眼科杂志，2021，57：232-236）</i>. | zh-cn |
pair_33723927 | Parents may adjust their breeding time to optimize reproductive output and reduce reproductive costs associated with unpredictable climatic conditions, especially in the context of global warming. The breeding performance of tropical bird species in response to local climate change is relatively understudied compared w... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为适应无法预测的气候波动，亲鸟常以调整繁殖时间的方式来降低繁殖成本并优化繁殖产出。与温带地区鸟类相比，气候波动对热带地区鸟类繁殖影响的研究还较缺乏。基于361巢白腰文鸟（ <i>Lonchura striata</i>）的野外数据，我们发现白腰文鸟繁殖季开始时间（波动范围在2月15日到6月22日之间）受高温干旱的影响而推迟。频繁降雨会减少窝卵数（4.52±0.75）和降低日存活率，但卵重（0.95±0.10 g）未受显著影响。巢日存活率在降水量较大的2018年（0.95±0.04）显著低于降水量适中的2017年（0.98±0.01）和2019年（0.97±0.00）。白腰文鸟的巢周期是 40.37±2.69天，其中孵化期13.10±... | zh-cn |
pair_33723928 | Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for parabiosis have been improved many times and are now widely accepted. However, resea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 并联共生（parabiosis）是通过手术方法将两只实验动物进行外科连接的一种历史悠久的动物模型。在过去的二十年里，该模型被广泛应用于生物医学研究，特别是在衰老、干细胞、神经科学和免疫等领域。虽然并联共生模型已经得到了不断改进和完善，但从手术操作到围术期管理，仍有诸多细节值得研究者们关注，以降低死亡率和提高并联共生的稳定性。尽管存在着自身的局限性，但作为一种不可替代的研究手段，并联共生动物模型在生物医学研究领域仍有广阔的应用前景。. | zh-cn |
pair_33723930 | Digital technologies use high-precision three-dimensional scanning, intelligence-aided design software, and multi-axis numerical control milling or 3D printing, which can produce restorations with reliable precision and suitable function. However, the development of digital technologies in the field of complete denture... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 数字化技术利用高精度三维扫描、智能辅助设计软件和多轴数控切削或3D打印技术，可以制作出精度可靠、功能适宜的修复体。然而，由于全口义齿操作的复杂性，数字化技术在全口义齿修复领域的研发进度相对缓慢。本文将从数字化全口义齿的研究现状以及临床应用两个方面，阐述目前数字化全口义齿在口腔修复临床和技工室应用和研发的进展情况。. | zh-cn |
pair_33723931 | Tooth preparation is a common operation in dental clinical practice. This procedure is irreversible and invasive from the point of view of tooth preservation. Conditions of the abutment tooth, treatment methods, and restoration materials for target restoration affect tooth preparation. To achieve the goals of tooth tis... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 不同修复方式及材料选择、拟预备牙体本身条件等都会对牙体预备手术产生影响。为了牙体保存、活髓保护及牙周健康等共识理念的实现，牙体预备量总体越少越好已成共识。支撑其实现的条件一是备选修复材料的综合性能进步、材料所需承载空间有效减少；二是预备量和形的数字化分析及实测技术的出现，使得导板下备牙量与修复空间全程实测核查成为可能，预备手术的引导方式也从凭借个人经验累积的目测徒手操作，发展到了采用数字引导联合显微操作进行等。这些进展也标志着精准的、可全程实测核查的引导式修复学的形成。本文将从数字化修复、引导式口腔修复及显微修复技术的视角，对牙体预备的数值要求与数量关系转移展开数字追问；并从测量四要素对现有数值要求做论证评价，指出统一测量方法、研发... | zh-cn |
pair_33723943 | Resolution of inflammation plays an important part in maintaining homeostasis. It is an actively programmed progress involving multiple immune cells and mediators. Specialized pro-resolving mediators (SPMs) derived from Ω-3 polyunsaturated fatty acids include resolvins, protectins and maresins, and they exert abilities... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 炎症消退机制是机体维持稳态的重要途径，是一个涉及大量免疫细胞和介质的程序化的主动过程。特异性促炎症消退介质（SPM）包括消退素、保护素和噬消素（maresins），是Ω-3多不饱和脂肪酸衍生的一类内源性脂质介质，在促炎症消退、宿主防御、器官保护和组织再生方面都可发挥积极作用。牙周炎是以菌斑生物膜为始动因素的牙周组织炎症性、破坏性疾病。不完善的促炎或促炎症消退机制，以及两者之间的失衡状态是牙周炎病理进展的重要因素。SPM结合组织特异性受体能够改善牙周组织炎症状态，保护牙槽骨，促进组织再生，调节免疫细胞抵抗致病菌。本文就SPM对牙周炎的作用，应用前景及面临的挑战作一综述。. | zh-cn |
pair_33723944 | Oral squamous cell carcinoma (OSCC) is the most frequent tumour in head and neck malignant. The current treatment is mainly based on surgery therapy, radiation therapy and chemical therapy. Meanwhile, there are many a defect in the treatment. For example, there are many defects in radiotherapy. Radioactive salivatitis ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 颌面及颈部的恶性肿瘤是最常见的恶性肿瘤之一，治疗以手术治疗、放疗、化疗相结合为主，同时治疗存在着很多不良反应，如放疗存在诸多并发症，其中便以放射性唾液腺炎最为常见。此外还有口腔干燥、口腔黏膜炎、猛性龋、放射性颌骨骨髓炎等，导致吞咽、咀嚼问题以及味觉功能障碍等一系列变化。目前，放射性唾液腺炎的研究进展迅速，但其机制较为复杂，本文就此领域的相关研究成果作一综述。. | zh-cn |
pair_33723945 | Speech could be used, because it was a neuromuscular movement without teeth contact. The method was stable, however it was used more in vertical relation deciding. More study was needed in the horizontal relation deciding. This article was to explain why and how to use phonetic method to decide jaws relation, through l... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 发音是口颌系统参与的脱离牙接触的肌肉神经运动，可通过发音时下颌的生理位置确定颌位关系。语音法相对稳定且较易操作，现阶段多应用于垂直关系的确定，在水平颌位关系上的应用需要进一步的临床研究。本文对语音法的原理及其在水平关系和垂直关系确定应用上的相关研究进行综述。. | zh-cn |
pair_33723946 | Cartilage stem cells (CSCs) are cells that self-proliferate, have surface antigen expression, and have multidirectional differentiation potential in the articular cartilage. CSCs, as an ideal source of stem cells, has a good application prospect in stem cell therapy. This article reviews the CSCs markers, cartilage dif... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 软骨干细胞是关节软骨中具有自我增殖、表面抗原表达特性及多向分化潜能的细胞，作为一种理想的干细胞来源，在干细胞治疗中有良好的应用前景。本文就软骨干细胞的标记、软骨分化信号通路、骨关节炎的临床治疗方法等研究进展进行综述。. | zh-cn |
pair_33723947 | Many patients with large-area tooth defect need cast post-core crown restoration. However, the color defect of the cast post-core will affect the final restorative result, especially that of the anterior teeth. A new technology of color masking by applying CERAMAGE polymeric porcelain to the cast metal post-core surfac... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 大面积牙体缺损需进行铸造桩核冠修复，铸造桩核因金属本身颜色缺陷，会影响修复体最终美学效果，前牙美学修复区更甚。本文介绍一种采用CERAMAGE聚合瓷遮色金属桩核，从而改善前牙全瓷修复体色彩呈现效果的方法，为大面积缺损患牙的美学修复提供改进方法。. | zh-cn |
pair_33724205 | Colorectal cancer (CRC) is caused by genetic and environmental factors, and the genetic component plays a significant role in CRC development. Currently, genome-wide association studies (GWAS) have identified a large number of genetic loci associated with CRC risk. In the post-GWAS era, more and more efforts focus on d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 结直肠癌(colorectal cancer, CRC)是受遗传与环境因素共同影响的复杂疾病,其中遗传因素发挥重要作用。至今,全基因组关联研究(genome-wide association studies, GWAS)已经发现了大量与结直肠癌风险相关的遗传变异。随之而来的后GWAS时代,越来越多的研究侧重于利用多组学数据和功能实验对潜在的致病位点进行解析。分析表明绝大多数风险单核苷酸多态性(single nucleotide polymorphism, SNP)位于非编码区,可能通过影响转录因子结合、表观遗传修饰、染色质可及性、基因组高级结构等,调控靶基因表达。本文对后GWAS时代结直肠癌致病位点的机制研究进行综述,阐述了后GWA... | zh-cn |
pair_33724207 | Animal domestication is the process of changing wild animals into domesticated animals that can be kept stably for a long period of time. As the content of the Neolithic agricultural revolution, domestication is one of the important milestones of the progress of human civilization. Due to the close relationship between... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 动物驯化是将野生动物改变为能够长期稳定饲养的家养动物的过程。作为新石器时代农业革命的内容,驯化是人类社会文明进步的重要标志之一。由于和人类的密切关系,驯化不仅改变了动物的野生状态,也改变了人类的生活习性和文明进程。动物驯化研究的关键问题包含驯化祖先是谁、驯化所产生的改变及驯化时间地点等。随着高通量基因组技术和对应分析方法的发展,目前研究动物驯化一般基于群体水平,在群体遗传学的框架下研究动物驯化过程中的重要事件。本文总结了群体遗传学下动物驯化研究的相关内容,包括群体动态历史、选择信号、基因交流等,着重介绍了基因选择初始时间和基因交流时间两个新的拓展内容及分析方法,概述了家猪(Sus scrofa f. domestica)、家鸡(Ga... | zh-cn |
pair_33724208 | As the most abundant biological entities on earth, bacteriophages (phages) were considered as the antagonists of bacteria. With the rapid development of genomics and molecular biology technologies, a subtle and complex relationship between phages and their host bacteria has been uncovered. Prophage refers to an intrace... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 噬菌体是地球上最多的生物实体,一直被认为是细菌的天敌。然而随着基因组学和分子生物学等技术的快速发展,人们发现噬菌体与宿主之间存在微妙而复杂的关系。前噬菌体是指溶原性细菌内存在的整套噬菌体DNA基因组,广泛分布在细菌基因组中,对调节细菌宿主生理具有重要作用,如参与调节宿主的毒力、影响生物膜形成、赋予宿主免疫力等。有趣的是,前噬菌体可以通过“监听”细菌的群体感应来调节自身的溶原-裂解状态。近年来,一些细菌中由前噬菌体编码的抗CRISPR蛋白的发现引起了人们对前噬菌体研究的关注。因此,对前噬菌体的研究可以为改造宿主和前噬菌体提供基础理论参考。本文对前噬菌体的预测、分布、分类及功能进行了综述,以期为进一步研究噬菌体与宿主间的关系提供基础。. | zh-cn |
pair_33724210 | Myostatin (MSTN) is a member of the transforming growth factor-β (TGF-β) family, and functions as an inhibitor of muscle growth. Disrupting the inhibitory effect of MSTN on growth can provide an effective way to increase the muscle yield of livestock and poultry. The cysteine knot motif of TGF-β can stabilize the struc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肌生长抑制素(myostatin, MSTN)是转化生长因子β (transforming growth factor-β, TGF-β)家族成员之一,是一种肌肉生长抑制因子。解除MSTN的生长抑制功能是提高畜禽肌肉产量的一种有效途径。TGF-β的半胱氨酸节结构基元(cystine knot motif) 能够稳定MSTN蛋白结构,对MSTN生物学功能的发挥具有重要调控作用。本研究应用CRISRP/Cas9基因编辑技术在两广小花猪肾细胞(Liang Guang small spotted pig kidney cells, LPKCs)中对<i>MSTN</i>基因外显子3进行编辑,破坏了其半胱氨酸节基元,以解除MSTN对靶基因的抑... | zh-cn |
pair_33724214 | The advent and development of single-cell whole-genome sequencing (scWGS) technology has shed lights on the genomic heterogeneities within biosamples at the single-cell resolution. The technology is particularly well-established in the recent decade and witnesses a variety of clinical applications, such as circulating ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着单细胞基因组测序技术的建立与发展,对细胞基因组特征的分析进入了单细胞水平。单细胞的基因组分辨率不但使研究人员能够在单细胞尺度上分析肿瘤细胞的异质性,也使得传统上难以检测的稀有细胞的基因组研究成为可能。这些稀有细胞往往具有重要的生物学意义或临床价值,如癌症患者血液中循环肿瘤细胞(circulating tumor cell, CTC)的基因组检测或三代试管婴儿植入前胚胎细胞的遗传缺陷诊断与筛查(preimplantation genetic diagnosis/screening, PGD/PGS)。本文总结了近年来发展的各种单细胞基因组扩增技术及其优缺点,并介绍了单细胞基因组测序技术在肿瘤生物学和临床检测中的应用,以期为单细胞基... | zh-cn |
pair_33724215 | The various coat colorations exhibited in different mammalian groups is an attractive biological phenomenon, and is also one of the excellent models for studying and understanding mammalian adaptive evolution. Coat color polymorphism in mammals plays an important role in avoiding predator, predation, courtship, and pro... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_33724216 | The mechanisms underlying the establishment of left-right (L-R) asymmetry in bilaterians is one of the central enigmas in developmental biology. Amphioxus is an important model in studying the mechanisms of animal asymmetry specification due to its particular phylogenetic position, vertebrate-like embryogenesis and bod... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 两侧对称动物左右体轴建立机制研究是发育生物学领域重要的基础科学问题之一。文昌鱼(amphioxus)由于其特殊的进化地位以及与脊椎动物相似的胚胎发育模式和身体构筑方式,是研究动物左右体轴建立机制的理想模式物种。近年来随着文昌鱼室内全人工繁育技术、高效显微注射技术和基因敲除技术的建立,国内外学者在左右体轴建立机制研究上取得了丰硕的成果。本文从文昌鱼胚胎左右不对称发育特点出发,总结了近期文昌鱼左右体轴建立方面取得的研究进展,并提出了文昌鱼左右体轴调控网络图：纤毛运动导致Hh蛋白在文昌鱼中不对称分布(L<R),从而导致Hh信号通路的不对称激活以及Cer的不对称表达(L<R),Cer对Nodal具有抑制作用,由此导致依赖于Nodal活性的基... | zh-cn |
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