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pair_33724217
Bacteria with the smallest genome contain genes necessary for self-sustaining replication only, giving the organisms advantages to serve as a potential industrial production platform. Many strains with reduced genomes have been constructed, owing to the development of high-throughput DNA sequencing and synthesis techno...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
具有最小基因组的细菌只包含维持自我生命复制所必需的基因,其作为一种潜在的工业生产平台具有诸多优势。由于高通量DNA测序和合成技术的发展,目前已经构建了多种缩减基因组的菌株。本文首先介绍了最小基因组的概念,其次总结了细菌必需基因的相关研究进展,然后梳理了人工缩减与合成微生物基因组的相关工作,最后探讨了在设计和组装基因组的过程中遇到的技术障碍和限制,以期为人工合成基因组的实验与应用提供理论参考。.
zh-cn
pair_33724218
Spinal muscular atrophy (SMA) is a common childhood neuromuscular disease inherited in an autosomal recessive pattern. The majority of SMA patients have a homozygous deletion of survival motor neuron 1 (SMN1) gene. As a special SMA carrier, the (2+0) genotype ofSMN1 poses a great challenge for carrier screening and fam...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
脊髓性肌萎缩症(spinal muscular atrophy, SMA)是一种儿童时期较为常见的神经肌肉病,属于常染色体隐性遗传。绝大多数SMA由运动神经元存活基因1 (survival motor neuron 1,SMN1)的纯合缺失突变所致。而SMN1的2+0基因型个体作为一种特殊的SMA携带者,给携带者筛查以及家系的遗传咨询带来了巨大的挑战。已有研究表明,g.27134T>G和g.27706_27707delAT多态位点变异对于Ashkenazi犹太人群中的2+0基因型个体具有提示作用。为进一步探究这两个多态位点是否在中国人群也具有特异性,本研究纳入了44例家系成员和204例已知SMN1基因拷贝数的对照样本。44例家系成员...
zh-cn
pair_33724219
Inflammatory bowel disease (IBD) has emerged as a public health challenge with high incidence, recurrence rates and low cure rate. Moreover, sustained inflammation increases the risk of colorectal cancer. The occurrence and progression of IBD are closely related to the genetic mutation. Previous genome-wide association...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
炎性肠病在全球范围内发生极其普遍,具有反复发作、难以治愈的特点,也是诱发结直肠癌的高风险因素之一。肠炎的发生与遗传因素密切相关,有报道发现位于GPR35基因座上的多个单核苷酸多态性(single nucleotide polymorphism, SNP)位点rs4676410、rs3749171和rs3749172与肠炎敏感性高度相关,但是GPR35基因在肠炎的发生发展进程中的功能及相关机制尚没有明确结论。为了研究GPR35在肠炎中的作用,首先通过CRISPR/Cas9技术构建Gpr35敲除小鼠,随后利用DSS诱导的肠炎模型评价Gpr35在肠炎发生中的作用,发现敲除小鼠在体重变化、DAI评分、肠上皮损伤以及炎性细胞浸润等肠炎相关指标...
zh-cn
pair_33724463
Respiratory sinus arrhythmia (RSA), an index of the parasympathetic nervous system, has recently gained attention as a physiological component of regulatory processes, social connectedness, and health. Within the context of romantic relationships, studies have operationalized and conceptualized RSA in disparate ways, o...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
呼吸窦性心律失常(RSA)是副交感神经系统的一个指标,近期的研究中作为调节过程、社会联系和健康的一个生理组成部分受到关注。针对恋爱关系情境中进行的研究,对RSA的操作和概念化的研究方式有所差别,它们无法提供清晰的研究结果的模式。本文综合了快速增加的文献作了系统性的综述,明晰了RSA在爱情关系中的作用。我们评估了对三个概念性假设的支持。(1)静止时基线RSA与更好的关系质量相关;(2)阶段性RSA反映了伴侣互动过程中不良的兆头和伴侣连接关系方面的变化;(3)恋爱伴侣之间RSA的生理联动与积极或消极的关系功能有关,这取决于联动的性质(例如,同相联动与反相联动)。我们找出26项实证研究,这些研究测试了RSA与恋爱关系指数(即关系满意度)之...
zh-cn
pair_33724463
Respiratory sinus arrhythmia (RSA), an index of the parasympathetic nervous system, has recently gained attention as a physiological component of regulatory processes, social connectedness, and health. Within the context of romantic relationships, studies have operationalized and conceptualized RSA in disparate ways, o...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La arritmia sinusal respiratoria (ASR), un índice del sistema nervioso parasimpático, ha sido objeto de atención recientemente como componente fisiológico de los procesos reguladores, la conexión social y la salud. Dentro del contexto de las relaciones amorosas, los estudios han operacionalizado y conceptualizado la AS...
es
pair_33728715
Interleukin (IL)-2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Canarypox virus locally expressing feline IL-2 is safe and can be used to treat equine sarcoids. Twenty horses of different breeds with a median age of eight years (interquartile range 6.0-13.3 years) a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景: 白细胞介素(IL)-2刺激抗肿瘤免疫, 并成功用于治疗不同的肿瘤。 假设/目的: 局部表达猫IL-2的金丝雀痘病毒是安全的, 可用于治疗马结节病。 动物: 研究纳入了20匹不同品种的马, 中位年龄为8岁 (四分位距6.0-13.3岁) , 共59种结节病。 方法: 在这项前瞻性临床试验中, 结节病每隔七天注射两次, 用表达猫IL-2的重组金丝雀痘病毒。在治疗前和第1、2、7和8天检测血常规 (CBC)和纤维蛋白原水平。 结果: 8匹马(40%)达到完全缓解,2匹马(10%)达到部分缓解。2匹马(10%)未观察到结节病大小变化, 5匹马(25%)疾病有所发展。3匹马(15%)的结节病显示初始缓解, 随后肿瘤生长。两次注射后,C...
zh-cn
pair_33728715
Interleukin (IL)-2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Canarypox virus locally expressing feline IL-2 is safe and can be used to treat equine sarcoids. Twenty horses of different breeds with a median age of eight years (interquartile range 6.0-13.3 years) a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
L’interleukine (IL)-2 stimule l’immunité anti-tumorale et est efficacement utilisée pour le traitement de différentes néoplasies. HYPOTHÈSES/OBJECTIFS: Canarypoxvirus exprimant localement IL-2 félin est sûr et peut être utilisé pour traiter les sarcoïdes équins. Vingt chevaux de différentes races avec un âge médian de ...
fr
pair_33728715
Interleukin (IL)-2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Canarypox virus locally expressing feline IL-2 is safe and can be used to treat equine sarcoids. Twenty horses of different breeds with a median age of eight years (interquartile range 6.0-13.3 years) a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Interleukin (IL)-2 stimuliert die Antitumor Immunität und wird erfolgreich zur Behandlung verschiedener Neoplasien eingesetzt. Das Kanarienpoxvirus, welches lokal felines IL-2 exprimiert ist sicher und kann verwendet werden, um equine Sarkoide zu behandeln. Es wurden zwanzig Pferde verschiedener Rassen mit einem median...
de
pair_33728715
Interleukin (IL)-2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Canarypox virus locally expressing feline IL-2 is safe and can be used to treat equine sarcoids. Twenty horses of different breeds with a median age of eight years (interquartile range 6.0-13.3 years) a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
A interleucina (IL)-2 estimula a imunidade antitumoral e é utilizada com sucesso no tratamento de diferentes neoplasias. HIPÓTESE/OBJETIVOS: O vírus canarypox que expressa IL-2 felina localmente é seguro e pode ser usado para tratar sarcóides equinos. Vinte cavalos de raças diferentes com idade mediana de oito anos (in...
pt
pair_33728715
Interleukin (IL)-2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Canarypox virus locally expressing feline IL-2 is safe and can be used to treat equine sarcoids. Twenty horses of different breeds with a median age of eight years (interquartile range 6.0-13.3 years) a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
la interleuquina 2 (IL-2) estimula la inmunidad antitumoral y se utiliza con éxito para el tratamiento de diferentes neoplasias. HIPÓTESIS/OBJETIVOS: El poxvirus de canarios que expresa localmente IL-2 felina es seguro y puede usarse para tratar sarcoides equinos. ANIMALES: se incluyeron en el estudio veinte caballos d...
es
pair_33728788
To examine risks of cancers, obesity-related cancers (eg, cancers in digestive organs, breast, ovary, kidney, thyroid, and myeloma), cancer-related mortality, and all-cause mortality in patients with type 2 diabetes mellitus (T2DM) and obesity who underwent bariatric surgery. A retrospective cohort of 1944 T2DM patient...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目标: 研究2型糖尿病患者在减重手术后发生癌症, 肥胖相关癌症(例如, 消化器官癌, 乳癌, 卵巢癌, 肾癌, 甲状腺癌和骨髓瘤), 癌症死亡和全因死亡的风险。 方法: 本项研究是一项回顾性队列研究, 共纳入了1944名在2006年至2017年期间未曾罹患过癌症的2型糖尿病合并肥胖症患者。其中, 手术组为345名接受过减重手术的患者, 对照组为1599名未接受过减重手术的患者。两组患者的基线水平采用了一比五倾向评分匹配以及倾向评分修剪进行平衡。 结果: 经过平均37个月的跟踪随访, 手术组发生癌症, 肥胖相关癌症, 癌症死亡与全因死亡的风险分别为3.2%, 1.4%, 0.9%和3.2%。手术组肥胖相关癌症的发病率以及乳癌或生殖器癌...
zh-cn
pair_33730821
Field survey is an important foundation for of birth cohort. In a field survey, data such as the environmental exposures, genetics, lifestyle and biological samples will be collected. This document establishes specifications for institutions' establishment, site preparation, coding system, the recruitment of participan...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
出生队列研究的现场调查围绕研究人群的环境、遗传、生活行为习惯等因素和生殖健康相关结局开展信息和生物样本采集,是出生队列建设不可或缺的重要基础。本文件就出生队列研究现场调查中的机构设置、现场准备、队列编码体系、研究对象招募及质量控制等主要工作制定规范。.
zh-cn
pair_33730822
The long-term follow-up is an important content of birth cohort, which focus on the dynamic cohort data collection at different stages including the pre-pregnancy, pregnancy, postpartum and fetal growth period. This document establishes specifications for the follow-up, the management of refusal to follow up and loss t...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
出生队列研究的长期随访围绕研究人群的环境、遗传、生活行为习惯等因素和生殖健康相关结局开展孕前、孕期、产后和子代生长发育不同阶段的长期、连续、动态的追踪随访,是出生队列研究工作的重要内容,也是出生队列研究取得成功的关键。本文件就出生队列长期随访、拒访和失访处理、研究对象依从性维护以及质量控制等主要工作制定规范。.
zh-cn
pair_33730823
Birth cohort participants information system is a software system with multiple functions including recode basic information, automatic administration, paper-less questionnaire survey, clinical data integration, data visualization. The efficiency and quality of cohort data were improved dramatically by using this syste...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
出生队列成员信息系统(以下简称“系统”)是一类包含出生队列家庭成员基本信息登记、自动化管理、无纸化问卷调查、临床信息整合、数据可视化展示等多种功能的软件系统,可显著提升出生队列建设的质量和效率。本文件就出生队列成员信息系统建设过程中的系统开发、验证和部署、系统操作终端和使用场景、系统模块及其功能、数据导出及系统的安全性等主要工作制定规范。.
zh-cn
pair_33730824
Hypertension is a major problem of public health that endangers the health of the oldest old. However, the current guidelines for hypertension management do not uniformly diagnose hypertension among the oldest old, nor recommend a normal blood pressure range, which is not convictive enough to support the decision makin...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
高血压是危害高龄老年人健康的重大公共卫生问题,然而国内外现行的高血压管理指南对老年人的高血压诊断标准不统一、没有推荐血压正常范围,不足以为高龄老年人血压相关不良事件的预防提供决策支持。本标准给出了中国高龄老年人血压水平适宜范围的指导建议,适用于全国各级医疗卫生机构工作人员评价高龄老年人血压水平,主要内容包括总体原则、血压水平评价方法和标准、测量条件保障、血压测量规范、实施途径等。本标准对提高我国高龄老年人血压管理和决策水平具有重要指导意义。.
zh-cn
pair_33730832
To understand the prevalence and etiological characteristics of hand, foot and mouth disease(HFMD) in Yangzhou, so as to provide scientific basis for prevention and control of HFMD. HFMD cases from six sentinel hospitals in Yangzhou from January 2015 to December 2019 were taken as the subject of study. The epidemiologi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
了解扬州地区手足口病(HFMD)流行现状及病原学特征,为该地区HFMD防控提供依据。以2015年1月至2019年12月扬州市6家哨点医院常规监测的HFMD病例为研究对象,对病例资料进行描述性流行病学分析,采用实时荧光定量PCR方法对病例标本进行肠道病毒核酸检测,并进行病原学特征分析。2015至2019年扬州市累计检测HFMD临床标本2 129份,共检出肠道病毒阳性1 151份(总阳性率为54.06%),包括EV71型148份(6.95%)、CA16型382份(17.94%)和其他型肠道病毒(其他EV)621份(29.17%)。不同年份(χ²=99.28, <i>P</i><0.05)、不同月份(χ²=92.09, <i>P</i><...
zh-cn
pair_33730833
From 2013 to 2014, the age of 924 residents recruited in Haikou City was (38±13) years old, of which 57.3% (529) were males. Those who chewed betel nuts accounted for 17.4% (161). According to the diagnostic criteria of substance abuse in the Fourth Edition of the Diagnostic and Statistical Manual of Mental Disorders, ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
2013—2014年,海口市招募的924名居民年龄为(38±13)岁,男性占57.3%(529名),嚼食槟榔者占17.4%(161名)。根据《精神障碍诊断和统计手册第四版》的物质滥用诊断标准,槟榔滥用检出率为7.0%(65名)。相对于年龄>30岁、受教育程度>6年、不吸烟人群,年龄15~30岁、受教育程度≤6年、有吸烟行为人群的槟榔滥用发生风险较高,<i>OR</i>(95%<i>CI</i>)值分别为4.21(1.48~11.99)、7.81(1.92~31.69)、13.53(4.15~44.11)。.
zh-cn
pair_33730834
The smoking cessation rate of 1 314 people at high risk of lung cancer in the area of lung cancer screening and early diagnosis and early treatment in Sichuan Province increased from 22.37% at baseline to 41.78% after screening (χ²=227.97, <i>P</i><0.001), and the smoking amount of persistent smokers decreased from 20 ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
1 314名四川省肺癌筛查及早诊早治项目地区肺癌高危人群的戒烟率从基线时的22.37%增至筛查后的41.78%(χ²=227.97,<i>P</i><0.001),持续吸烟者的吸烟量从20支/d降至15支/d(<i>t</i>=11.76,<i>P</i><0.001);肺癌筛查中出现阳性结果者更倾向于戒烟或持续保持戒烟状态,男性、年龄较小、教育程度较低将增加持续吸烟或复吸的风险(<i>P</i><0.05)。.
zh-cn
pair_33730835
Among the staff of Beijing Chao-Yang Hospital, Capital Medical University, who received the inactivated SARS-CoV-2 vaccine on January 30 in 2021, 28 recipients were selected for this research. Samples for nucleic acid tests were collected from the surface of the recipients' both hands before and after vaccination. The ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
从2021年1月30日接种新型冠状病毒灭活疫苗的首都医科大学附属北京朝阳医院工作人员中选择28位受试者作为研究对象进行研究,在疫苗接种前后分别对受种者的双手进行采样核酸检测的同时,对接种疫苗后粘贴在接种部位的针后贴进行核酸检测。接种疫苗前,受种者双手表面采集的标本核酸检测结果均为阴性。接种疫苗后,受种者双手表面采集的标本核酸检测结果阳性共3例,核酸检测结果可疑共8例,阳性率占10.7%;共收集25例使用过的针后贴标本,核酸检测结果阳性24例,核酸检测结果可疑1例,阳性率占96%。新型冠状病毒灭活疫苗接种的针后贴存在核酸污染的风险。.
zh-cn
pair_33730836
Cervical cancer is one of the most common gynecological malignancies, and its morbidity and mortality are among the highest. Persistent infection of high-risk types of HPV is the main reason for its onset, with types 16 and 18 being the most prevalent. Circular RNA (circRNA) is a single-stranded circular non-coding RNA...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
宫颈癌是最常见的妇科恶性肿瘤之一,发病率和死亡率位居前列。高危型人乳头状瘤病毒(human papilloma virus,HPV)持续感染是其发病的主要原因,以16、18型最为典型。环状RNA(circular RNA,circRNA)是RNA前体通过首尾共价相连,形成的单链环状非编码RNA,具有miRNA海绵、结合RNA结合蛋白(RBP)以及翻译蛋白质等功能,在多种疾病的进展中发挥重要作用。目前, circRNA在宫颈癌中的研究尚处于早期阶段,现就环状RNA在高危HPV感染、宫颈癌发生发展和放化疗敏感性方面的新进展进行阐述。.
zh-cn
pair_33730837
In April 2016, the Global Polio Eradication Initiative (GPEI) adjusted its polio vaccination strategy, converting trivalent oral polio vaccine (tOPV) into bivalent oral polio vaccine (bOPV), and withdrawing type 2 oral polio vaccine (OPV2) globally. However, after the withdrawal of OPV2, there were many outbreaks of ty...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
全球消灭脊髓灰质炎行动(GPEI)于2016年4月调整脊髓灰质炎疫苗免疫接种战略,将三价口服脊髓灰质炎疫苗(tOPV)转换为二价口服脊髓灰质炎疫苗(bOPV),并在全球全面撤出Ⅱ型口服脊髓灰质炎减毒活疫苗(OPVⅡ)。然而在OPVⅡ撤出以后,亚洲和非洲多地暴发Ⅱ型循环疫苗衍生脊髓灰质炎病毒(cVDPVⅡ)。为了彻底消灭脊髓灰质炎病毒,GPEI于2010年启动研发新型Ⅱ型口服脊髓灰质炎减毒活疫苗(nOPVⅡ),并于近年开始考虑是否有必要重启OPV。本文概述了OPVⅡ撤出前后cVDPVⅡ的流行病学情况,影响OPV重启的相关因素以及nOPVⅡ相关研究进展。.
zh-cn
pair_33730838
Haloacetaldehydes (HALs), as emerging disinfection by-products in drinking water, are the third largest group by weight of identified disinfection by-products (DBPs) in drinking water. The formation of HALs is associated with the level of natural organic matter and halide in the source water, the treatment process of d...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
卤乙醛类消毒副产物是饮用水中新发现的消毒副产物,位居饮用水中消毒副产物总量第三,其生成与水中天然有机物和卤化物水平、饮用水处理工艺和消毒剂类型有关。新近研究显示卤乙醛类消毒副产物比饮用水中受控的三卤甲烷类消毒副产物和卤乙酸类消毒副产物有更强的细胞毒性和遗传毒性。目前仅有少数国家和地区对饮用水中检出率高的三氯乙醛设定了限值,但日益积累的证据表明非受控的卤乙醛类消毒副产物对人群健康的潜在风险更高。本文综述了当前饮用水中卤乙醛类消毒副产物的生成与转化、细胞毒性、遗传毒性等方面的研究进展,展望了未来卤乙醛类消毒副产物毒理学研究应关注的问题,以支撑科学的饮用水卫生标准研制。.
zh-cn
pair_33730839
In this paper, the history and current situation of environmental health standardization in China are reviewed, and the experience and shortcomings in the process of environmental health standardization in China are analyzed, suggestions for the next step of environmental health standards are also put forward.
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
本文在对我国环境健康标准化工作的发展历程进行梳理的基础上,分析了当前国际国内环境与健康标准化工作面临的机遇和挑战,并对近期环境健康标准化工作提出具体的建议。.
zh-cn
pair_33730840
Human papillomavirus infection is the main pathogenic factor leading to cervical cancer. About 630 000 new cancers are caused by HPV infection every year, among which cervical cancer accounts for the highest proportion (83%). The burden of cervical cancer is serious in China. Research data shows that there were nearly ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
人乳头瘤病毒(HPV)的持续感染是导致子宫颈癌的主要致病因素,全球每年约63万例新发癌症由HPV感染所致,其中子宫颈癌占比最高,达83%。中国子宫颈癌的疾病负担严重,研究数据显示,2018年中国子宫颈癌新发病例近11万,死亡病例近5万,分别约占全球发病和死亡总数的20%和16%。世界卫生组织(WHO)的立场文件中明确指出,HPV疫苗的接种可有效预防HPV相关疾病的发生。纵观全球的临床研究及真实世界数据,HPV疫苗显示出良好的保护效力及安全性。截至2019年10月,全球已有98个国家和地区将HPV疫苗纳入国家免疫计划。然而,伴随接种范围的增加及适应证的扩大,HPV疫苗的安全性成为了全球高度关注的公共卫生问题。自2006年HPV疫苗上市...
zh-cn
pair_33738830
Calls for biodiversity conservation practice to be more evidence based are growing, and we agree evidence use in conservation practice needs improvement. However, evidence-based conservation will not be realized without improved access to evidence. In medicine, unlike in conservation, a well-established and well-funded...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对于生物多样性保护实践应更加注重证据的呼声已越来越高, 我们也同意在保护实践中需要改进证据的使用。然而, 如果不能获取更好的证据, 也将无从实现基于证据的保护。与保护领域不同的是, 在医学领域中, 由已确立并资金充足的中介人或中介组织与医务人员合作, 来整合与决策相关的第一手研究资料, 从而使这些研究证据更易于获取。这些中介机构会准备有针对性的证据摘要, 并将其分发给需要进行较强时效性、主观性决策的医务人员。为了提高效率, 中介机构 (我们称之为“证据桥梁”) 应根据医务人员的优先排序来确定研究课题、整合证据、准备和分发易获得且易使用的证据摘要, 并发展和保持研究者与医务工作者的联系网络。基于对保护及环境管理领域证据中介研究的文献调...
zh-cn
pair_33738830
Calls for biodiversity conservation practice to be more evidence based are growing, and we agree evidence use in conservation practice needs improvement. However, evidence-based conservation will not be realized without improved access to evidence. In medicine, unlike in conservation, a well-established and well-funded...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Vinculación entre la Investigación y la Práctica en la Conservación Resumen Cada vez existen más peticiones para que las prácticas de conservación de la biodiversidad estén más basadas en evidencias, además de que apoyamos la idea de que el uso de evidencias en la práctica de la conservación necesita mejorar. Sin embar...
es
pair_33738989
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide with high rates of transmission and substantial mortality. To date, however, no effective treatments or enough vaccines for COVID-19 are available. The roles of angiotensin ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
新型冠状病毒肺炎(COVID-19)是由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的一种大流行疾病,目前正在全球范围内迅速蔓延,其传播速度快,死亡人数高。迄今为止,尚无针对COVID-19的有效治疗或疫苗。血管紧张素转化酶2 (ACE2)和刺突蛋白(spike)在COVID-19治疗中的作用是当前的研究重点。在本研究中,我们探索了ACE2和spike作为靶点开发抗SARS-CoV-2病毒药物的潜力。我们分析了临床数据、测序数据和受体结合能力。其中,临床资料显示,COVID-19合并肾素-血管紧张素系统异常的患者早期症状多,预后差。然而,ACE2表达水平与COVID-19进展之间的关系尚不清楚。因此,ACE2可能不...
zh-cn
pair_33739489
Trichophyton benhamiae was diagnosed in a 9-year-old female dog by histopathological evaluation, fungal culture and confirmation by sequencing of the internal transcribed spacer region of ribosomal DNA. Successful therapy was achieved with itraconazole, bathing with miconazole and chlorhexidine shampoo, and topical app...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
通过组织病理学评价、真菌培养和核糖体DNA内转录间隔区测序,确诊了1只9岁雌性犬感染了本哈米毛癣菌。使用伊曲康唑、咪康唑和氯己定香波洗澡,并外涂稀释的次氯酸钠,得到成功治愈。.
zh-cn
pair_33739489
Trichophyton benhamiae was diagnosed in a 9-year-old female dog by histopathological evaluation, fungal culture and confirmation by sequencing of the internal transcribed spacer region of ribosomal DNA. Successful therapy was achieved with itraconazole, bathing with miconazole and chlorhexidine shampoo, and topical app...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Trichophyton benhamiae a été diagnostiqué chez une chienne de 9 ans par examen histopathologique, culture fongique et confirmation par séquençage de la région ITS (internal trasbcriber spacer) de l’ADN ribosomique. Une guérison thérapeutique a été obtenue par de l’itraconazole, des shampooings de miconazole et chlorhex...
fr
pair_33739489
Trichophyton benhamiae was diagnosed in a 9-year-old female dog by histopathological evaluation, fungal culture and confirmation by sequencing of the internal transcribed spacer region of ribosomal DNA. Successful therapy was achieved with itraconazole, bathing with miconazole and chlorhexidine shampoo, and topical app...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Trichophyton benhamiae wurde bei einer 9-Jahre alten Hündin mittels histopathologischer Evaluierung, Pilzkultur und der Bestätigung durch Sequenzierung der internen transkribierten Spacer Region der ribosomalen DNA diagnostiziert. Eine erfolgreiche Behandlung wurde mittels Itrakonazol, Shampoobehandlung mit Miconazol u...
de
pair_33739489
Trichophyton benhamiae was diagnosed in a 9-year-old female dog by histopathological evaluation, fungal culture and confirmation by sequencing of the internal transcribed spacer region of ribosomal DNA. Successful therapy was achieved with itraconazole, bathing with miconazole and chlorhexidine shampoo, and topical app...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Trichophyton benhamiae foi diagnosticado em uma cadela de 9 anos através de avaliação histopatológica, cultura de fungos e confirmação por sequenciamento da região espaçadora transcrita interna do DNA ribossomal. Sucesso terapêutico foi obtido com o uso de itraconazol, banho com shampoo à base de miconazol e clorexidin...
pt
pair_33739489
Trichophyton benhamiae was diagnosed in a 9-year-old female dog by histopathological evaluation, fungal culture and confirmation by sequencing of the internal transcribed spacer region of ribosomal DNA. Successful therapy was achieved with itraconazole, bathing with miconazole and chlorhexidine shampoo, and topical app...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Se diagnosticó infección por Trichophyton benhamiae en una perra de 9 años mediante evaluación histopatológica, cultivo de hongos y confirmación mediante secuenciación de la región espaciadora transcrita interna del DNA ribosómico. Se logró un tratamiento exitoso con itraconazol, baños con champú de miconazol y clorhex...
es
pair_33739551
Southern sea otters (Enhydra lutris nereis) rely on intact pelage for thermoregulation, and thus clinically significant demodicosis and associated alopecia can cause morbidity and death. This study aimed to describe lesions associated with follicular Demodex sp. infestation, estimate the prevalence and intensity of inf...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景: 方海獭依赖于被毛完整来进行体温调节, 因此具有临床意义的蠕形螨病和造成的脱毛可导致其发病和死亡。 假设/目的: 本研究旨在描述毛囊蠕形螨侵染造成的病变, 评估侵染的流行率和严重程度, 描述关键解剖区域的螨虫分布, 并评估是否存在造成病变的螨虫, 以及宿主风险因素。 动物: 2005年至2018年, 在加利福尼亚中部海岸搁浅并进行尸检的20只野生南方海獭。 方法和材料: 采自外观正常和异常的头部、会阴、生殖器、乳头和四肢皮肤, 评估显微镜下螨虫及螨虫相关的病理学结果。 结果: 在55%的水獭皮肤中观察到毛囊内螨虫, 20%患有临床蠕形螨病。在2个病例中, 蠕形螨病导致了死亡或因此而人道处死。尽管在外观正常的皮肤中, 通过显微镜...
zh-cn
pair_33739551
Southern sea otters (Enhydra lutris nereis) rely on intact pelage for thermoregulation, and thus clinically significant demodicosis and associated alopecia can cause morbidity and death. This study aimed to describe lesions associated with follicular Demodex sp. infestation, estimate the prevalence and intensity of inf...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La loutre de mer de Californie (Enhydra lutris nereis) utilise son pelage intact pour sa thermorégulation et ainsi, une démodécie cliniquement significative et l’alopécie associée peuvent causer une morbidité et la mort. HYPOTHÈSES/OBJECTIFS: Cette étude a pour but de décrire les lésions associées à une infestation fol...
fr
pair_33739551
Southern sea otters (Enhydra lutris nereis) rely on intact pelage for thermoregulation, and thus clinically significant demodicosis and associated alopecia can cause morbidity and death. This study aimed to describe lesions associated with follicular Demodex sp. infestation, estimate the prevalence and intensity of inf...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Der Seeotter des Südpazifiks (Enhydra lutris nereis) benötigt zur Thermoregulierung zwingend ein intaktes Haarkleid und daher kann eine klinisch signifikante Demodikose und eine damit einhergehende Alopezie Erkrankung und Tod verursachen. Diese Studie zielte darauf ab, Veränderungen, die mit einer follikulären Demodex ...
de
pair_33739551
Southern sea otters (Enhydra lutris nereis) rely on intact pelage for thermoregulation, and thus clinically significant demodicosis and associated alopecia can cause morbidity and death. This study aimed to describe lesions associated with follicular Demodex sp. infestation, estimate the prevalence and intensity of inf...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
As lontras do mar do Sul (Enhydra lutris nereis) dependem da pelagem intacta para termorregulação e, portanto, demodiciose clinicamente significativa e alopecia associada podem causar morbidade e morte. HIPÓTESE/OBJETIVOS: Este estudo teve como objetivo descrever lesões associadas à infestação folicular por Demodex sp....
pt
pair_33739551
Southern sea otters (Enhydra lutris nereis) rely on intact pelage for thermoregulation, and thus clinically significant demodicosis and associated alopecia can cause morbidity and death. This study aimed to describe lesions associated with follicular Demodex sp. infestation, estimate the prevalence and intensity of inf...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
las nutrias marinas del sur (Enhydra lutris nereis) dependen de un pelaje en buenas condiciones para la termorregulación y, por lo tanto, la demodicosis clínicamente significativa y la alopecia asociada pueden causar morbilidad y muerte. HIPÓTESIS/OBJETIVOS: Este estudio tuvo como objetivo describir las lesiones asocia...
es
pair_33739620
Acupuncture is a therapeutic intervention of traditional Chinese medicine, characterized by the insertion of a fine metal needle through the human body's skin at an acupuncture point (acupoint). Acupuncture has become from cultural curiosity to fast-growing complementary and alternative medicine therapy worldwide, incl...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
针灸是一种治疗干预手段, 其特征是将金属细针插入人体皮肤的穴位。在包括美国在内的全世界范围, 针灸已经从文化好奇的现象转变成快速增长的补充和替代医学疗法。准确定位体表穴位的能力对于针灸治疗的实施至关重要; 然而, 穴位的定位往往因从业者而异。因此, 为引起人们对穴位定位在针灸研究和临床实践中的关注, 笔者将重点阐述穴位定位在医学 (如解剖学和针灸学) 教学中的运用。此外, 还需要进一步研究来确定是否可以通过使用可靠的工具来验证具有特异性的穴位定位。针灸师需要控制穴位定位的不协调性, 今后也应发展更准确的定位方法。.
zh-cn
pair_33746210
Typical ocular coloboma is caused by defective closure of the embryonal fissure. The occurrence of coloboma can be sporadic, hereditary (known or unknown gene defects) or associated with chromosomal abnormalities. Ocular colobomata are more often associated with systemic abnormalities when caused by chromosomal abnorma...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
摘要: 典型的眼组织缺损是由胚胎裂闭合不全引起的。眼组织缺损可以为偶发、遗传性 (已知或未知的基因缺陷)或与染色体异常有关。眼组织缺损多与染色体异常引起的全身异常有关。眼部表现差异多样。比如被眼眶囊肿压迫时, 其中一眼几乎无法视物、视觉功能丧失, 而另一只眼的结构和功能却丝毫不受影响。眼底的变异性则涉及到组织缺损的大小(前后和横向的范围)以及视盘和黄斑中心凹的受累程度。当组织缺损累及视盘和黄斑的中心凹时, 或合并视网膜脱离、脉络膜新生血管膜、白内障、因屈光不正引起的弱视等, 则会影响视力。虽然眼组织先天性异常无法治疗, 但上述大多数并发症在很大程度上是可以治疗的。目前, 组织缺损相关性视网膜脱离的手术治疗已经取得了良好的效果。但由于...
zh-cn
pair_33749018
Although threats to global biodiversity are well known, slowing current rates of biodiversity loss remains a challenge. The Aichi targets set out 20 goals on which the international community should act to alleviate biodiversity decline, 1 of which (Target 1) aims to raise public awareness of the importance of biodiver...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
尽管全球生物多样性面临的威胁已众所周知, 但要减缓目前生物多样性丧失的速度仍然是一项挑战。 “爱知目标” 提出了 20 个目标来要求国际社会采取行动以缓解生物多样性下降, 其中一个目标 (目标 1) 旨在提高公众对生物多样性重要性的认识。虽然目标 1 的传统指标的时空覆盖度较低, 但保护文化组学指标展示了如何在全球范围内量化生物多样性意识。我们效仿地球生命力指数 (Living Planet Index) 的方法设计了一个物种认知指数, 基于维基百科的浏览量来衡量人们对物种认识的变化。针对国际自然保护联盟 (IUCN) 列出的 41,197 个物种, 我们在 10 种语言的维基百科上基于 2015 年 7 月 1 日到 2020 年...
zh-cn
pair_33749018
Although threats to global biodiversity are well known, slowing current rates of biodiversity loss remains a challenge. The Aichi targets set out 20 goals on which the international community should act to alleviate biodiversity decline, 1 of which (Target 1) aims to raise public awareness of the importance of biodiver...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
El Índice de Sensibilización de Especie como Medida de Culturomia de la Conservación para la Sensibilización Pública por la Biodiversidad Resumen Aunque las amenazas a la biodiversidad mundial son bien conocidas, reducir las tasas actuales de pérdida de la biodiversidad todavía es un desafío. Los objetivos de Aichi est...
es
pair_33749024
Wildlife provides food, medicine, clothing, and other necessities for humans, but overexploitation can disrupt the sustainability of wildlife resources and severely threaten global biodiversity. Understanding the characteristics of consumer behavior is helpful for wildlife managers and policy makers, but the traditiona...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
野生生物为人类提供食物、药品、衣物和其他必需品, 但过度开发会破坏野生生物资源的可持续性并严重威胁全球生物多样性。了解野生生物消费者的消费行为对于野生生物管理者和政策制定者很有帮助, 但是传统的调查方法费力、费时。 相较而言, 文化组学可以更有效地识别消费野生生物的消费特征。作为文化组学方法的研究案例, 我们基于社交媒体和百度搜索引擎的数据研究了虎骨酒在中国的消费情况。虎骨酒是被购买最多的虎制品之一, 其消费与盗猎这一野生老虎生存面临的巨大威胁密切相关。我们在一个流行的社交媒体网站上检索 “虎骨酒 ”一词, 并关注了创建于 2012 年 1 月 1 日至 2018 年 12 月 31 日的帖子。随后我们对涉及虎骨酒购买、出售、消费相...
zh-cn
pair_33749024
Wildlife provides food, medicine, clothing, and other necessities for humans, but overexploitation can disrupt the sustainability of wildlife resources and severely threaten global biodiversity. Understanding the characteristics of consumer behavior is helpful for wildlife managers and policy makers, but the traditiona...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Uso de Datos de Culturomia y Redes Sociales para Caracterizar el Consumo de Fauna Resumen La vida silvestre proporciona alimentos, medicinas, vestimenta y otras necesidades para los humanos, pero si es sobreexplotada se puede perturbar la sustentabilidad de los recursos silvestres y amenazar severamente a la biodiversi...
es
pair_33749027
Ongoing loss of biological diversity is primarily the result of unsustainable human behavior. Thus, the long-term success of biodiversity conservation depends on a thorough understanding of human-nature interactions. Such interactions are ubiquitous but vary greatly in time and space and are difficult to monitor effici...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
生物多样性的持续丧失主要是人类不可持续行为造成的结果。因此, 生物多样性保护的长期成功取决于对人与自然相互作用的深入理解。这种互作普遍存在但有很大的时空差异, 难以在大空间尺度上有效监测。然而, 信息时代为更好地理解人与自然的互动提供了新的机会, 因为日常生活的许多方面都已有数字化的记录。保护文化组学是一个新兴的研究领域, 旨在利用数字数据资源和方法来研究人类与自然的互动, 从而为相应时空尺度的保护研究提供新的工具。然而, 与相关数据的识别、获取和分析相关的技术挑战阻碍了文化组学方法的广泛应用。为了克服这些阻碍, 我们构建了一个保护文化组学研究框架, 以解决数据获取、分析和固有偏倚的问题。文化组学数据的主要来源包括网页、社交媒体和其...
zh-cn
pair_33749027
Ongoing loss of biological diversity is primarily the result of unsustainable human behavior. Thus, the long-term success of biodiversity conservation depends on a thorough understanding of human-nature interactions. Such interactions are ubiquitous but vary greatly in time and space and are difficult to monitor effici...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Fuentes de Información Digital y Métodos para la Culturomia de la Conservación Resumen La continua pérdida de biodiversidad es el resultado principal del comportamiento humano insostenible. Por esto, el éxito a largo plazo de la conservación de la biodiversidad depende de una comprensión exhaustiva de las interacciones...
es
pair_33749040
Culturomic tools enable the exploration of trends in human-nature interactions, although they entail inherent biases and necessitate careful validation. Furthermore, people may engage with nature across different culturomic data sets differently. We evaluated people's digital interest and engagement with plant species ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
尽管文化组学工具包含内在的偏倚, 需要仔细验证, 但它可用于探索人类与自然互动的趋势。此外, 不同文化组学特征的人群可能会以不同的方式与自然互动。我们基于维基百科和谷歌的数据, 评估了人们对植物的喜爱和参与程度, 并探讨了这些喜爱模式对保护的意义。作为案例研究, 我们探索了以色列最流行的植物物种的搜索痕迹。我们分析了希伯来语维基百科4年间的每日页面浏览量和以色列10年间的谷歌每日搜索量, 并用一系列植物属性对这两个数据集中植物物种流行度进行了建模, 从而进一步探索了人们对每个物种喜爱的季节性趋势。我们发现, 人们在维基百科和谷歌上与植物互动的方式存在差异。总的来说, 人们在用谷歌时更多地搜索对人类有用的物种, 而在维基百科上, 具有...
zh-cn
pair_33749040
Culturomic tools enable the exploration of trends in human-nature interactions, although they entail inherent biases and necessitate careful validation. Furthermore, people may engage with nature across different culturomic data sets differently. We evaluated people's digital interest and engagement with plant species ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Combinación de las Fuentes de Culturomia para Descubrir las Tendencias en la Popularidad y el Interés Estacional por las Plantas Resumen Las herramientas utilizadas por la culturomia permiten la exploración de las tendencias en las interacciones humano-naturaleza, aunque conllevan sesgos inherentes y necesitan de una v...
es
pair_33749044
Social media data are being increasingly used in conservation science to study human-nature interactions. User-generated content, such as images, video, text, and audio, and the associated metadata can be used to assess such interactions. A number of social media platforms provide free access to user-generated social m...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
社交媒体数据正越来越多地用于保护科学, 以研究人类与自然的互动。用户发布的内容如图像、视频、文本、音频以及相关的元数据可用于评估此类互动。许多社交媒体平台都可以自由访问用户发布的社交媒体内容。然而, 与其它涉及人类的研究一样, 基于社交媒体数据的科学研究需要遵守数据隐私和数据保护的最高标准, 即使使用的是公开数据。如果社交媒体数据被滥用, 个人用户的隐私和福祉将面临巨大风险。我们通过基于欧盟《通用数据保护条例》的案例研究, 研究了在确保数据主体权利的同时使用社交媒体数据的法律依据。在研究中使用社交媒体数据的风险包括有意和无意的错误识别, 这有可能对被识别个体造成心理或身体上的伤害。在收集、存储、保护、共享和管理社交媒体数据时, 为了...
zh-cn
pair_33749044
Social media data are being increasingly used in conservation science to study human-nature interactions. User-generated content, such as images, video, text, and audio, and the associated metadata can be used to assess such interactions. A number of social media platforms provide free access to user-generated social m...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Cómo Abordar las Preocupaciones por Privacidad al Usar las Redes Sociales en las Ciencias de las Conservación Resumen Cada vez se usan más los datos de las redes sociales en las ciencias de la conservación para estudiar las interacciones humano-naturaleza. El contenido generado por usuarios (imágenes, videos, textos y ...
es
pair_33749051
The recent growth of online big data offers opportunities for rapid and inexpensive measurement of public interest. Conservation culturomics is an emerging research area that uses online data to study human-nature relationships for conservation. Methods for conservation culturomics, though promising, are still being de...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在线大数据的增长为快速简便地衡量公众兴趣提供了机会。保护文化组学是一个新兴的研究领域, 利用在线数据来研究保护中人与自然之间的关系。保护文化组学的方法虽然很有前景, 但仍在开发和完善当中。本研究探索了将在线百科全书--维基百科用作保护文化组学资源的潜力以及将维基百科数据用于保护的方法。维基百科庞大的规模、广泛的应用、底层数据结构, 以及对其内容和使用分析的开放访问, 使其非常适合于保护文化组学研究。而维基百科数据的局限性包括缺少某些元数据的位置信息, 以及许多用户内在动机的信息有限。在使用维基百科数据进行保护时需要考虑七个方法步骤, 包括元数据选择、时间性、生物分类、语言代表性、维基百科地理、物理和生物地理, 以及比较指标。对这些方...
zh-cn
pair_33749051
The recent growth of online big data offers opportunities for rapid and inexpensive measurement of public interest. Conservation culturomics is an emerging research area that uses online data to study human-nature relationships for conservation. Methods for conservation culturomics, though promising, are still being de...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La Wikipedia como Instrumento de Medición del Interés Público por la Biodiversidad y la Conservación Resumen El crecimiento reciente de los datos masivos en línea ofrece oportunidades para la medición rápida y asequible del interés público. La culturomia de la conservación es un área emergente de investigación que util...
es
pair_33749054
Understanding the activities and preferences of visitors is crucial for managing protected areas and planning conservation strategies. Conservation culturomics promotes the use of user-generated online content in conservation science. Geotagged social media content is a unique source of in situ information on human pre...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
了解游客的活动及喜好对保护区管理和保护策略的制定至关重要。保护文化组学提倡在保护科学中使用用户生成发布的在线内容, 而有地理标签的社交媒体内容正是人们在自然中出现和活动的现场信息的独特来源。虽然发布在社交媒体平台上的照片是潜在的信息来源, 但人工分析大量照片仍十分费力。本研究探索了最先进的计算机视觉方法在研究人与自然互动方面的应用。我们使用语义聚类、情景分类和目标检测等方法对国内外游客在芬兰国家公园拍摄的照片进行了自动分析, 结果表明可以用计算机视觉从用户生成发布的照片中提取人与自然的互动信息。不同方法通过揭示与数据集水平、景观摄影效果和人类活动相关的广泛的视觉主题而相互补充。带有地理标记的照片展示了国家公园不同区域的情况 (如人们...
zh-cn
pair_33749054
Understanding the activities and preferences of visitors is crucial for managing protected areas and planning conservation strategies. Conservation culturomics promotes the use of user-generated online content in conservation science. Geotagged social media content is a unique source of in situ information on human pre...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Exploración de las Interacciones Humano-Naturaleza en los Parques Nacionales por Medio de Fotografías en Redes Sociales y Visión por Computadora Resumen La comprensión de las actividades y preferencias de los visitantes es crucial para el manejo de las áreas protegidas y la planeación de las estrategias de conservación...
es
pair_33749881
Transboundary conservation is playing an increasingly important role in maintaining ecosystem integrity and halting biodiversity loss caused by anthropogenic activities. However, lack of information on species distributions in transboundary regions and understanding of the threats in these areas impairs conservation. W...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
跨境保护在维持生态系统完整和阻止人类活动引起的生物多样性丧失方面起着重要的作用。然而, 跨境区域的物种分布信息和所受威胁的认识都很匮乏, 这不利于进一步的保护。在印-缅生物多样性热点地区, 我们为中国云南省及其毗邻的缅甸, 老挝和越南的跨境区域提供了一个空间保护计划。通过分析物种分布格局, 近期土地利用变化以及为大多数物种提供了生境的天然林的连通性时空动态, 我们识别了该跨境区域的保护和恢复优先区。我们利用等同连接面积(ECA)指数来评估连通性。该指数可以测量一个物种在其扩散距离范围内可以到达的总的生境数量。我们从标本和专著中收集了21,004个植物和脊椎动物物种并分析了197,845条分布记录, 结果显示云南省边境地区具有最高的物...
zh-cn
pair_33749881
Transboundary conservation is playing an increasingly important role in maintaining ecosystem integrity and halting biodiversity loss caused by anthropogenic activities. However, lack of information on species distributions in transboundary regions and understanding of the threats in these areas impairs conservation. W...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Planeación de la Conservación en las Fronteras de China con Myanmar, Laos y Vietnam Resumen La conservación transfronteriza cada vez juega un papel más importante en la preservación de la integridad del ecosistema y en el freno a la pérdida local de la biodiversidad causada por las actividades antropogénicas. Sin embar...
es
pair_33751669
Arbitrary modeling choices are inevitable in scientific studies. Yet, few empirical studies in conservation science report the effects these arbitrary choices have on estimated results. I explored the effects of subjective modeling choices in the context of counterfactual impact evaluations. Over 5000 candidate models ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在科学研究中随意选择模型的现象是难以避免的。然而, 保护科学的实证研究很少会报道这些随意的选择对结果估计的影响。本研究在反事实影响评估的背景下探讨了主观模型选择的影响。研究者基于统计匹配算法的选择(如遗传和最近马氏距离匹配)、这些算法的参数化(如匹配的数量), 以及对特定协变量(如最近城市距离, 坡度, 降雨)的纳入情况的合理改变, 设计了超过 5000 个候选模型, 来有效地研究刚果民主共和国维龙加国家公园的建立对树木覆盖丧失和碳储量随时间变化的影响。研究者从 5000 个候选模型中随机挑选了 2000 个模型, 以确定哪种主观模型选择对结果的影响最大。所有有效模型均表明, 2000-2019 年间维龙加国家公园树木覆盖丧失减少,...
zh-cn
pair_33751669
Arbitrary modeling choices are inevitable in scientific studies. Yet, few empirical studies in conservation science report the effects these arbitrary choices have on estimated results. I explored the effects of subjective modeling choices in the context of counterfactual impact evaluations. Over 5000 candidate models ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Selecciones Subjetivas de Modelos y la Contundencia de las Evaluaciones de Impacto en las Ciencias de la Conservación Resumen Las selecciones arbitrarias de modelos son inevitables en los estudios científicos. Sin embargo, pocos estudios empíricos en las ciencias de la conservación reportan los efectos de estas selecci...
es
pair_30132990
Small-scale fisheries collectively have a large ecological footprint and are key sources of food security, especially in developing countries. Many of the data-intensive approaches to fishery management are infeasible in these fisheries, but a strategy that has emerged to overcome these challenges is the establishment ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
小型渔业在整体上有很大的生态意义, 它们是食物保障的重要来源, 尤其是在发展中国家。然而, 渔业管理中的许多数据密集型的方法对小型渔业并不适用, 但是一项为克服这些挑战的策略应运而生, 即渔业领地使用权 (territorial use rights for fisheries (TURFs)。这个方法为利益相关团体建立了专属捕鱼区, 以排除团体之间捕鱼竞争。然而, 如何设定 TURFs 的大小仍是一个关键的难题, TURFs 太大则共用的利益相关者太多, 会阻碍集体行动; 而太小目标鱼类会在 TURFs 间进进出出的移动, 团体实际上不能独享这些鱼类。我们通过应用理论模型来预测 TURFs 的情况, 评估了涉及这一设计挑战的全球 ...
zh-cn
pair_30132990
Small-scale fisheries collectively have a large ecological footprint and are key sources of food security, especially in developing countries. Many of the data-intensive approaches to fishery management are infeasible in these fisheries, but a strategy that has emerged to overcome these challenges is the establishment ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Diseño de Compensaciones en la Administración Basada en Derechos de las Pesquerías de Pequeña Escala Resumen Las pesquerías de pequeña escala tienen una gran huella ecológica de manera colectiva y son fuentes importantes de seguridad alimenticia, especialmente en los países en desarrollo. Muchas de las estrategias carg...
es
pair_30139024
Accompanied with more elaborate and deeper exploration, immunotherapy has been considered one of the most important therapeutic manners for tumor treatment besides conventional operative, chemotherapeutic, radiotherapeutic and targeted-therapeutic strategies. The application of programmed death-1 (PD-1) antibody has pr...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
随着研究的不断深入,免疫治疗已经成为继手术治疗、放疗、化疗及靶向治疗之后,肿瘤治疗的又一重要方式。程序性细胞死亡受体1(PD-1)抗体为患者提供了新的治疗选择,并成为免疫治疗领域的研究重点。PD-1抗体获批应用于恶性黑色素瘤等不同类型肿瘤的治疗,为大量患者带来临床获益,表现为持续的病灶稳定,甚至完全缓解。然而,PD-1抗体表现出良好疗效和应用前景的同时,也出现了越来越多的耐药现象。尽管目前关于PD-1抗体耐药的形成机制知之甚少,但是不断探索PD-1抗体的耐药机制,研究新型免疫治疗模式,规避耐药现象的发生,减少耐药的不良影响,甚至逆转耐药,将有助于指导临床适时调整治疗策略,不断提高免疫治疗的疗效,给患者带来更持久的生存获益。.
zh-cn
pair_30151963
Urban sprawl and the rising popularity of water-sensitive urban design of urban landscapes has led to a global surge in the number of wetlands constructed to collect and treat stormwater runoff in cities. However, contaminants, such as heavy metals and pesticides, in stormwater adversely affect the survival, growth, an...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
随着城市的扩张和城市景观中水敏城市设计的日益流行, 全球范围内为收集和处理城市雨水径流而建造的湿地数量急剧增加。然而, 雨水中的污染物, 如重金属和杀虫剂, 对栖息在这些湿地的动物的生存、生长和繁殖都会产生负面影响。目前存在的一个关键问题是野生动物能否识别和避开高度污染的湿地。我们选择了澳大利亚墨尔本的 67 个城市湿地, 调查了池塘繁殖的蛙类是否会尝试在那些不利于其后代健康的湿地中繁殖。结果表明, 即使在污染最严重的湿地中, 蛙类物种丰富度与污染物 (重金属和杀虫剂) 浓度也没有显著相关性。对出现的蛙类物种数和单个物种出现概率产生最大积极影响的是湿地边缘植被的比例, 说明蛙类喜欢栖息在植被丰富的湿地, 无论其污染程度如何。这些湿地...
zh-cn
pair_30151963
Urban sprawl and the rising popularity of water-sensitive urban design of urban landscapes has led to a global surge in the number of wetlands constructed to collect and treat stormwater runoff in cities. However, contaminants, such as heavy metals and pesticides, in stormwater adversely affect the survival, growth, an...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Ocupación de Ranas en Humedales Contaminados de Paisajes Urbanos Resumen La mancha urbana y la popularidad creciente del diseño urbano sensible al agua (WSUD, en inglés) han llevado a una oleada mundial de humedales construidos para recolectar y tratar el flujo de aguas pluviales en las ciudades. Sin embargo, los conta...
es
pair_30152013
Reflecting Teams (RTs) are an internationally recognized clinical consultation methodology, first developed by Tom Andersen in 1985. Over the last three decades, family therapists around the world have used RTs to enhance treatment. However, this innovation to family therapy practice is not well-standardized nor evalua...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
反映团队(RTs)是一项国际认可的临床咨询方法。该方法首先由Tom Andersen在1985年(Andersen, 1992)提出。在过去的三十年中,全世界家庭心理咨询师都使用了RTs来提升治疗效果(e.g., Brownlee, Vis, & McKenna, 2009; Höger, Temme, Reiter, & Steiner, 1994)。然而,这项对于家庭心理咨询行业的创新没有标准化或被评估。本文中描述的试点研究试图扩大先前对于RTs的研究并定量考察在大学医疗中心精神机构家庭心理咨询参与者的RTs。初步分析显示在参加了一个RT后家庭成员可能感受到更有希望,并相信自己能更好的在面临压力时彼此支持,一起工作时更有信心并解...
zh-cn
pair_30152013
Reflecting Teams (RTs) are an internationally recognized clinical consultation methodology, first developed by Tom Andersen in 1985. Over the last three decades, family therapists around the world have used RTs to enhance treatment. However, this innovation to family therapy practice is not well-standardized nor evalua...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Los “equipos reflexivos” (Reflecting Teams, RTs) son una metodología de consulta clínica reconocida a nivel internacional que fue desarrollada por primera vez por Tom Andersen en 1985 (Andersen, 1992). Durante las últimas tres décadas, los terapeutas familiares de todo el mundo han usado los equipos reflexivos para opt...
es
pair_30152205
Antibiotics are critical weapons that were used for combating human pathogens. However, the heavy use of antibiotics leads to the increased and widely spread of antimicrobial resistance. The antimicrobial resistance is not only a medical problem, but also social and economic concerns, involving public health, environme...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
抗生素是人类对抗病原微生物感染的重要“武器”。然而,抗生素的大规模使用导致细菌耐药性不断增强并广泛传播。细菌耐药不仅是医学问题,同时也是社会和经济问题,涉及公共卫生、环境污染、食品安全等诸多领域。本专刊从临床耐药与流行病学、动物及境耐药、细菌耐药机制、抗菌药物研发和耐药防控策略等角度对细菌耐药性问题进行了较系统的综述和探讨,为全面认识细菌耐药现状、深入开展耐药机制研究并制定综合防控策略等提供参考。.
zh-cn
pair_30152208
Overuse of antibiotics in livestock farming has enriched antibiotic-resistant genes as well as resistant bacteria in farm animals and their related environments. These antibiotic-resistant genes can spread to the natural environments by horizontal gene transfer and even to the food chain, posing a serious threat to the...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
畜牧养殖业中大量抗生素的使用,导致养殖动物及其相关环境中存在大量的耐药基因/耐药细菌。这些耐药基因可以借助基因水平转移等方式在环境中进一步扩散,甚至进入食品动物随食物链传播,对生态环境、食品安全和人类健康造成极大的威胁。随着基因组学研究手段的不断进步,养殖动物及其相关环境中耐药基因的多样性和生态学分布规律被广泛揭示。文中综述了相关领域耐药基因的研究进展,探讨了其对人体健康的潜在影响,并对未来的研究方向进行了展望。.
zh-cn
pair_30152209
World Health Organization has recognized antibiotic resistance is one of the serious threats to public health and food-safety in the 21st century. Recently, the antibiotic resistance gene (ARG) has been widely considered as a new pollutant. Now, many studies suggested that animal farm is one of the major reservoirs of ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
抗生素耐药性被世界卫生组织认为是21 世纪人类面临的最大的公共卫生安全问题之一。近年来,抗生素耐药基因作为一种新型污染物而受到广泛关注。养殖场现已成为耐药基因的一个重要储库,耐药菌及耐药基因随着动物排泄物进入环境,从而加速了耐药基因在环境中的传播。畜禽养殖环境中耐药基因和耐药菌可能经食物链、空气等途径传至人类,给人类健康带来巨大威胁。文中结合最新文献,主要介绍了动物养殖场抗菌药物耐药菌和耐药基因的分布特点、耐药基因的持留和传播扩散、研究方法等方面的研究进展,为食品动物养殖环境的抗菌药物耐药性风险评估提供一定支持。.
zh-cn
pair_30152211
Overuse of antibiotics in aquaculture, husbandry and healthcare has led to antibiotics residues in the enviuronment and the generation of antibiotic resistant bacteria that can be transferred into the human gut through food chain. Based on literatures, we reviewed the influence of bacterial resistance on intestinal flo...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
抗生素在养殖业、医疗业及制药业的广泛应用导致环境中的细菌耐药性日益严重,环境中的抗生素及耐药细菌一旦进入人体肠道,将破坏肠道菌群稳态,对人体健康造成威胁,而残存于饮食中的环境污染物则加剧了细菌耐药造成的人体健康影响。文中在总结大量文献的基础上,阐述了细菌耐药对人体和动物肠道菌群的影响机制及其相关的机体免疫调控,以环境中影响人体肠道菌群获得耐药性的来源作为切入点,阐述抗生素和耐药细菌进入人体肠道后对人体肠道菌群结构和耐药基因组成的影响,以及与人体免疫和免疫调节相关疾病之间的相关机制,并对今后的研究方向进行了展望。.
zh-cn
pair_30152212
TA (Toxin-Antitoxin) systems are widely spread in chromosomes and plasmids of bacteria and archaea. These systems consist of two co-expression genes, encoding stable toxin and sensitive antitoxin, respectively. The toxicity of toxins usually inhibits bacterial growth and antitoxins can neutralize the toxins. Interactio...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
毒素-抗毒素 (Toxin-Antitoxin,TA) 系统广泛存在于原核生物和古细菌的染色体和质粒中。此系统由2 个共表达的基因组成,分别编码稳定的毒素蛋白和易降解的抗毒素,毒素通常发挥毒性作用抑制细菌生长,而抗毒素则可中和毒性,二者相互作用对细菌生长状态起精密调节作用。根据TA 的组成和抗毒素的性质,目前已经发现有6 型TA,这些TA 系统在细菌中发挥的作用一直是近年来学者们研究的热点,文中对细菌TA 的功能研究进展进行了综述。.
zh-cn
pair_30152213
Currently, there are many studies on the mechanism of antibiotic resistance in Mycobacterium tuberculosis (Mtb), but there are few studies on its regulatory mechanism. Post-translational modifications (PTMs) have been recognized for their important role in controlling cellular dynamics such as metabolism and stress res...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目前对于结核分枝杆菌 (Mycobacterium tuberculosis,Mtb) 耐药产生机制研究得较多,但对其调控机制的研究较少。翻译后修饰 (Post-translational modifications,PTMs) 在结核菌多种生理途径 (如代谢、应激反应等)中发挥重要调控作用,而它们和结核菌耐药之间的关系逐渐引起了研究者的关注。文中介绍了结核菌抗生素耐受机制以及存在的一些PTMs,重点讨论了PTMs 在调控结核杆菌耐药机制中的潜在作用,以期为新型抗结核药物研发提供新的切入点。.
zh-cn
pair_30152214
Beta-lactams are the most widely used antibiotics. One of the principle mechanisms for Gram-negative bacteria to resist β-lactams is by producing β-lactamases that degrade β-lactams. This review highlights two regulatory mechanisms for inducing β-lactamase in Gram-negative bacteria. In the ampR-ampC paradigm, the induc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
β-内酰胺类抗生素是应用最广的一类抗菌药物。β-内酰胺酶能将β-内酰胺类抗生素水解,其诱导表达是革兰氏阴性菌对该类抗生素产生耐药性的最主要原因。文中重点综述了革兰氏阴性菌中β-内酰胺酶诱导表达的两种调控机制。在经典的ampR-ampC 调控系统中,β-内酰胺酶的诱导表达与肽聚糖循环密切相关,并且LysR 型转录因子AmpR 发挥核心的调控作用。近年来发现β-内酰胺类抗生素能激活双组分系统,从而诱导β-内酰胺酶的表达。最后,讨论了革兰氏阴性菌中β-内酰胺类耐药今后的研究方向。.
zh-cn
pair_30152215
Horizontal gene transfer contributes to the spread of antibiotic-resistance cassettes, the distribution of toxin-encoding phages and the transfer of pathogenicity islands. Natural transformation, which is the process of competent cells to uptake free DNA from environment and to recombine this DNA into the chromosome, i...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
水平基因转移对耐药基因传播、编码毒素基因质粒的扩散和毒力岛的转移等过程具有重要的生物学意义。自然转化是指具有感受态的细菌从外界摄取并整合裸露DNA,是水平基因转移的方式之一。细菌发生自然转化极大地促进了耐药基因在不同细菌间的播散,导致细菌对抗生素耐药,给临床治疗带来极大的困难。许多细菌具备自然转化能力,但不同细菌自然转化过程存在着差异。细菌自然感受及转化的诱发及效率亦受到多种因素的影响。文中着重于阐述不同细菌的自然转化机制及其影响因素。.
zh-cn
pair_30152216
Tuberculosis (TB), caused by Mycobacterium tuberculosis, has become a major human infectious disease. The existing first-line and second-line TB drugs have poor treatment outcomes in patients with MDR-TB and XDR-TB. There is an urgent need for new and better drugs to treat tuberculosis due to lengthy and complex treatm...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
由结核分枝杆菌感染引起的结核病是人类重要传染病之一。临床上结核菌耐药性日趋严重,不断出现的耐多药及广泛耐药结核病患者,使现有的一线至五线药物不能满足结核病防控需求。微生物来源的天然产物是药物先导化合物的重要来源。环境中存在大量常规培养条件下未培养微生物,同时微生物基因组中也存在大量未被表达的“沉默代谢途径”。运用各种方法对未培养微生物进行再培养,同时激活微生物的沉默代谢途径,进而获得潜在的新型抗生素药物已成为目前研究热点。文中系统阐述了近年来获取天然化合物所采用的微生物非常规培养技术及沉默代谢途径激活策略,同时总结了利用这两种方法获得的新型抗结核天然产物,并展望了这些方法在抗结核药物进一步研发中的应用前景。.
zh-cn
pair_30152217
With the emergence and globally spread of drug-resistant bacteria, the discovery and development of new antibacterial drugs is imminent. The symbiotic bacteria distributed in different parts of the body can produce a variety of antibacterial molecules to inhibit the colonization and infection of pathogenic bacteria. Hu...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
随着耐药细菌的出现和广泛传播,开发新型抗菌药迫在眉睫。分布在人体不同部位的共生菌能够产生多种抗菌分子以抑制病原菌的定植和感染。人体共生菌的抗菌分子为研发全新结构和作用机制的药物提供了潜在的资源宝库,随着生物信息学、合成生物学、基因组学等组学技术的进一步发展,对人体共生菌抗菌分子的挖掘也会更加深入,为解决耐药问题提供了有效的途径。文中回顾了目前所发现的人体共生菌产生的抗菌分子,并介绍了几种用于挖掘人体共生菌这一天然抗菌药物的资源宝库的方法。随着现代生物工程技术的发展,人体共生菌的抗菌分子将会得到更加全面、系统的探索和应用。.
zh-cn
pair_30152218
There is an urgent need to discover new anti-tuberculosis compounds with novel mechanisms of action in order to deal with tuberculosis and drug-resistant tuberculosis. In this article, the feature of several promising novel compounds with potential anti-tuberculosis activities is summarized, focusing on the drug target...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
随着结核病耐药现象越来越严重,迫切需要开发新型抗结核药物,而大部分的药物开发主要依赖于新型的抗生素靶标的发现。文中综述了2016 年以来新出现的具有开发为抗结核药物潜力的新化合物,并重点阐述了这些新化合物所针对的抗生素靶标,将有助于针对这些靶标进一步开发新型抗结核药物。.
zh-cn
pair_30152219
Carbapenem-resistant Enterobacteriaceae (CRE) is rising rapidly all over the world, and challenges clinical diagnosis and treatment by various genotypes. This paper summarizes the characteristics and diagnostic methods of CRE. CRE can be divided into three categories and five families with various characteristics and r...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
碳青霉烯耐药的肠杆菌科细菌 (Carbapenem-resistant Enterobacteriaceae,CRE) 在全球快速上升,已出现了不同的基因型,为临床诊治提出新的挑战。CRE 分为具有不同特点和耐药基因的三大类五大家族;诊断方法包括Kirby-Bauer 法初筛试验,碳青霉烯类药物的协同试验 (EDTA 与美罗培南、苯硼酸与美罗培南的双纸片抑制法)、改良的Hodge 试验、显色培养基检测等CRE 筛选试验,而Carba NP 比色微管试验、PCR 及测序等为CRE确认试验。上述方法均各有其优缺点,可根据当地的主要流行CRE 型别和实验条件选择应用。.
zh-cn
pair_30152220
Antimicrobial resistance is on the rise while the number of antibiotics being brought to market continues to drop. Drug-resistant genes and drug-resistant bacteria infection have seriously threatened human health. Therefore, antimicrobial resistance presents an ongoing challenge that requires multifaceted approaches in...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
细菌耐药性 (Antimicrobial resistance,AMR) 持续增长,但新上市抗生素数量却持续下降。抗生素耐药基因 (Antimicrobial resistance gene,ARG) 和抗生素耐药菌感染已严重威胁人类健康。因此,需要多方面联合采取措施来应对AMR 所带来的各种挑战,包括创新生物医药、改善抗生素使用和抗生素耐药监测系统、减少抗生素耐药基因产生速度、阻止健康护理相关感染和多重抗生素耐药菌传播与扩散、开发微生物学快速诊断方法与设备、减少临床和兽医抗生素滥用等。庆幸的是,AMR 已受到各国政要、科学家和企业家等的高度重视与支持,相信随着新技术、新产品的不断问世和管理新措施的不断出台,AMR 问题一定会得到控...
zh-cn
pair_30152221
Antibiotic resistance affects the development of the world economy and threats public health. China is one of the countries with the most severe abuse of antibiotics. Here, we describe the causes of antibiotic resistance in the environment, human and animals as well as the status of antibiotic resistance. Based on the ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
抗生素耐药作为威胁公共卫生的巨大挑战已经制约了世界经济发展。我国抗生素使用量大,是世界上抗生素滥用最严重的国家之一。文中对人群、食用动物、环境中抗生素耐药产生的原因以及抗生素耐药现状进行综述,针对我国目前抗生素使用与耐药情况,从One Health 理念提出了促进抗生素的科学使用、积极探索新型抗生素研发、建立抗生素立体监测网络系统、推广抗生素耐药教育、预防感染等措施,呼吁建立跨学科、跨部门、跨地域的交流与合作,推进我国抗生素耐药防控工作进一步开展,加强环境保护,维护人类与动物的共同健康。.
zh-cn
pair_30154285
To explore the therapeutic effects of bone marrow-derived mesenchymal stem cells (BMSCs) on premature ovarian failure (POF) in mice induced by cyclophosphamide (CTX) and the possible mechanisms.
 Methods: Mouse BMSCs were identified through detection of cell surface markers by flow cytometry. The model of mouse POF was...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:研究小鼠同种异体骨髓来源间充质干细胞(bone marrow derived mesenchymal stem cells,BMSCs)在环磷酰胺诱导的小鼠卵巢早衰(premature ovarian failure,POF)损伤中的修复作用及其机制。方法:分离培养小鼠BMSCs,应用流式细胞术检测BMSCs表面标志;小鼠腹腔注射50 mg/(kg.d)环磷酰胺,连续15 d,建立POF模型。建模后第7天,按每只小鼠2×106个BMSCs尾静脉注射移植到POF模型小鼠体内;移植后第7天,采用HE染色观察细胞移植治疗后小鼠卵巢结构变化,RT-PCR检测BMSCs移植对POF小鼠卵泡发育相关基因mRNA表达的影响。结果:BMSCs...
zh-cn
pair_30154287
In order to apply the index system for clinical evaluation of implementation effect in hospitals.
 Methods: A total of 862 patients with vaginal delivery from 9 hospitals were randomly divided into an clinical pathway group (n=496) and a control group (n=366). The patients in the control group received traditional trea...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:将临床路径实施效果评价指标体系应用于自然临产阴道分娩病种,验证此指标体系的科学性和实用性。方法:共抽取9家医院862例自然临产阴道分娩患者,分为临床路径组(n=496)和对照组(n=366)。临床路径组根据自然临产阴道分娩临床路径流程进行诊疗,对照组采用常规方法进行诊疗,应用临床路径实施效果评价指标体系对临床路径实施效果进行评价。结果:临床路径组住院天数、术前住院天数、住院费用等15个评价指标均优于对照组(P<0.05),体现了实施临床路径的优越性;综合评价结果显示:不同等级(二级医院、三级医院),不同性质(专科医院,综合医院)的临床路径组综合评分均高于对应等级和性质的对照组,且二级医院临床路径组综合评分(Ci=0.7967)...
zh-cn
pair_30154289
To examine the role of LY294002 in cardiac function and myocardial structure in dilated cardiomyopathy (DCM) rats.
 Methods: Fifty-two male SD rats were randomly assigned to a control group (n=16) and a DCM group (n=36). The DCM rats were induced by intraperitoneal injection of adriamycin, and the control rats were giv...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:探讨PI3K抑制剂LY294002对腹腔注射阿霉素诱导的扩张型心肌病(dilated cardiomyopathy,DCM)大鼠模型心肌结构及心功能的影响。方法:将52只雄性SD大鼠随机分为对照组(n=16)和模型组(n=36),模型组前6周通过腹腔注射阿霉素建立DCM大鼠模型,对照组同期腹腔注射等量的生理盐水。观察2周后(8周末)每组随机处死6只存活大鼠;9~16周将建模成功的24只模型大鼠随机分为DCM组(n=12)和LY294002组(n=12),分别予以生理盐水和LY294002,16周末处死所有存活大鼠。8周末及16周末,所有存活大鼠行血浆氨基末端脑钠肽前体(NT-proBNP)浓度检测及超声心动图检查,并取8周末及...
zh-cn
pair_30154290
To explore the characteristics of brain structure in patients with long-term withdrawal of methamphetamine-dependence.
 Methods: A total of 44 patients with withdrawal of methamphetamine-dependent for more than 14 months were recruited, who met the diagnostic criteria for substance dependence in the fifth edition of th...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:了解长期戒断甲基苯丙胺依赖患者的脑结构特点。方法:招募44名长期戒断甲基苯丙胺依赖患者(戒断时间大于14个月)及40名健康对照作为研究对象,在年龄、受教育程度、吸烟、饮酒方面进行匹配,使用西门子3.0T skyra头部正交线圈行结构功能磁共振研究;采用自制量表了解受试者基本情况和毒品使用情况,获取三维脑结构图像,然后采用基于体素的形态学分析法进行数据分析,行双样本t检验(cluster size>20,P<0.001,未校正)获得两组间差异性脑灰质区域。结果:与健康对照组比较,长期戒断甲基苯丙胺依赖患者双侧小脑脚、左侧颞上回、右侧枕叶舌回灰质体积增加,双侧距状裂周围皮质、双侧楔叶灰质体积缩小,其中左侧楔叶、左侧小脑脚灰质体积与...
zh-cn
pair_30154291
To examine the expression of transforming growth factor 1(TGF-β1) and bone morphogenetic protein-9 (BMP-9) in human nonunion tissues, and to evaluate the clinical significance.
 Methods: The number of hypertrophic nonunion tissue samples and atrophic nonunion tissue samples were collected from Department of Orthopedics...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:检测肥大性骨不连组织与萎缩性骨不连组织中转化生长因子β1和骨形态发生蛋白-9表达的差异,评价两种骨不连组织在成骨潜能上的区别。方法:收集2010年至2014年中南大学湘雅二医院和上海交通大学医学院苏州九龙医院骨科住院的肥大性和萎缩性骨不连患者各20例。利用免疫组织化学SP二步法及病理图像分析软件IPP6.0对骨不连断端间组织转化生长因子β1和骨形态发生蛋白-9的表达进行半定量分析。根据骨不连类型、患者年龄和骨不连时间对其进行统计学分析。结果:肥大性骨不连患者中转化生长因子β1和骨形态发生蛋白-9 的吸光度值分别为0.3236±0.0390和0.1337±0.0400,萎缩性骨不连患者中转化生长因子β1和骨形态发生蛋白-9的吸光...
zh-cn
pair_30154292
To explore the clinical effect of total hip replacement with soft tissue release and true acetabulum reconstruction on treating osteoarthritis secondary to severe development dysplasia of the hip.
 Methods: From January 2005 to January 2011, 23 hips in 21 patients with osteoarthritis secondary to Crowe III development ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:探讨运用软组织松解和真臼重建的全髋关节置换术治疗重度发育性髋关节脱位伴骨性关节炎的临床疗效。方法:回顾性分析2005年1月至2011年1月21例(23髋)Crowe III型发育性髋关节脱位伴骨性关节炎的患者行合并软组织松解和真臼重建的全髋关节置换术的临床疗效,其中女18例,男3例,年龄(45.1±13.2)岁。2例行双侧全髋关节置换术,19例行单侧全髋关节置换术。术前Harris评分为39.7±5.6。结果:术后随访(110±46)个月,关节痛症状明显缓解。所有患者在软组织切断松解后,股骨头均复位于真臼部位。术后有1例患者出现坐骨神经刺激症状,术后3个月内恢复正常,术后肢体不等长长度(11.0±3.5) mm。术后Harri...
zh-cn
pair_30154293
To explore the influence of gender and age on the measurement of cone beam CT (CBCT) in normal and occluded craniofacial hard tissues for Han nationality in Changsha area.
 Methods: A total of 80 CBCT data of normal and occluded craniofacial hard tissues for Han nationality in Changsha area were collected, including 40...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:探究性别、年龄等差异对长沙地区汉族正常牙合颅颌面硬组织的三维口腔颌面锥形束计算机断层扫描(cone beam CT,CBCT)测量结果的影响。方法:收集80例长沙地区汉族正常牙合颅颌面硬组织CBCT数据,分为成人组[40例,男16例,女24例,年龄(17.57±1.83)岁]和儿童组[40例,男16例,女24例,年龄(11.50±1.26)岁]。采用Dolphion Imaging软件进行三维头影测量,比较不同性别、年龄之间的差异。结果:成人组内男性和女性颅颌面硬组织对称性均较好(非对称率R最大值为6.39%,最小值为0.08%);成人组性别比较显示:前腭宽度、腭宽度、上切牙突距、下切牙突距、舌骨-下颌平面、会厌基底部宽度、腭...
zh-cn
pair_30154294
To explore the influential factors for hospitalization costs regarding the final phase of malignant tumor patients in Shanghai, and to explore the relevant policy for reasonable control of hospitalization costs.
 Methods: A total of 10 065 patients with malignant tumors were enrolled in this study. The multiple linear ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:探讨上海市恶性肿瘤患者终末期住院费用的影响因素,并针对其影响因素提出合理控制住院费用的相关政策建议。方法:选取2014—2015年上海市医疗机构收治的10 065例恶性肿瘤患者为研究对象,运用多元线性回归分析恶性肿瘤患者终末期住院费用的影响因素。结果:10 065例患者住院时间的中位数为43 d,年龄为(70.73±12.87)岁;其中61.66%的住院患者为男性,恶性肿瘤患者住院费用的中位数为55 447.84元;住院费用的变化与转归情况、医疗保险类型、医院级别、医院类型、肿瘤部位、住院天数、是否手术、年龄、距离死亡时间、性别存在联系。结论:恶性肿瘤患者的终末期住院费用存在接近死亡效应,应当合理配置医疗资源,采取综合措施,合...
zh-cn
pair_30154295
To explore the distribution of psychological aging in healthy population and its relationship with telomere length in peripheral blood leukocyte, and to provide reference for aging evaluation.
 Methods: Stratified random samples were obtained according to age and they were divided into 9 age groups. The age-related psy...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:探索自制健康人心理性衰老量表反映个体心理性衰老程度的分布规律及其与外周血白细胞端粒长度的关系,为科学评价衰老提供参考。方法:根据所设置的9个年龄组分层随机抽样,运用课题组自制量表收集调查对象的心理性衰老现况资料;分析个体心理性衰老得分情况及其与年龄、端粒长度的相关性。结果:现场实证研究共发放问卷2 100份,有效回收2 060份,回收有效率为98.10%,男女比为0.95:1。心理性衰老总分为8.62~23.14,认知功能、情绪、人格、动机与需要4个维度衰老分值分别为2.25~10.77,1.45~6.73,0.96~4.22,1.50~7.18;年龄与心理性衰老总分相关性较高(r=0.721,P<0.001)。被测对象端粒相...
zh-cn
pair_30154296
The bladder cancer is a common malignant tumor in urinary system. The standard treatment for muscle invasive bladder cancer is radical cystectomy. Considering the damage to patients and the drastic effect on their life caused by the radical cystectomy, many domestic and overseas scholars suggest a comprehensive treatme...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
膀胱癌是泌尿系常见的恶性肿瘤,其中肌层浸润性膀胱癌的标准治疗方案是膀胱根治性切除术,但该手术对于患者自身及术后生活均会造成巨大的影响。对此,不少国内外学者指出部分合适的患者可以选择以保留膀胱的手术为主,同时辅以放射治疗、化学治疗等辅助性治疗的综合治疗方案,术后对患者进行密切的随访,其疗效同根治性膀胱切除术相近,且手术风险及并发症的发生率也显著低于根治性膀胱切除术,而患者则可以保留有功能的膀胱。.
zh-cn
pair_30154297
Recurrent seizures lead to abnormal expression of synaptic proteins, reorganization of synapse and formation of abnormal neuron network. Recently, it is identified that the synaptic proteins are involved in epileptogenesis. The abnormal expression of several synaptic regulatory proteins and postsynaptic membrane recept...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
反复的癫痫发作可导致突触蛋白的表达异常、突触重塑和异常神经元网络的形成,这是难治性癫痫的病理生理学机制之一。近年来发现突触蛋白在原发性癫痫的发病机制中同样发挥重要的作用。多个突触调控蛋白以及突触后膜受体蛋白表达异常可导致癫痫发作。绝大多数的抗癫痫药物是以离子通道为作用靶点,但卡马西平及唑尼沙胺可通过影响突触融合蛋白及可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体复合物的功能而发挥抗癫痫作用。突触囊泡蛋白2A是新型抗癫痫药物左乙拉西坦、布瓦西坦和seletracetam的作用靶点。.
zh-cn
pair_30154298
Gap junction (GJ) plays an important role in cell communication. It is widely distributed in mammalian organs and tissues (except red blood cells and skeletal muscle). The overexpression of GJ and the enhancement of function are closely related to the mechanism of peripheral and central pain sensitization. Astrocytes a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
缝隙连接在细胞通讯中发挥了重要的作用,它广泛存在于哺乳动物的各器官和组织中(红细胞、骨骼肌除外)。缝隙连接的过度表达和功能的增强与外周及中枢疼痛敏化机制密切相关。星形胶质细胞是中枢神经系统中最主要的细胞类型,其主要的缝隙连接蛋白是缝隙连接蛋白43。缝隙连接蛋白43在慢性疼痛中的作用包括调控缝隙连接的表达、耦联及活性变化。.
zh-cn
pair_30154300
To investigate the clinical characteristics of a patient with motor neuron disease, which caused sleep-disordered breathing (SDB) and alveolar hypoventilation syndrome, and to improve the diagnosis rate for this disease.
 Methods: Retrospectively analyze the diagnosis and treatment process for a 52 year-old male patien...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:分析运动神经元病并发睡眠呼吸障碍、肺泡低通气综合征的临床特征,以提高对该病的认识和诊断。方法:回顾性分析中南大学湘雅二医院呼吸内科收治的1例因“呼吸困难、气促、乏力4个月余”至当地多家医院就诊的疑难病例,最终诊断为运动神经元病,阻塞性睡眠呼吸暂停低通气综合征,肺泡低通气综合征的52岁男性患者的临床诊治过程,并以(“运动神经元病”或“肌萎缩侧索硬化”或”进行性延髓麻痹”或“进行性肌萎缩”或“原发性侧索硬化”)和(“睡眠呼吸暂停”或“睡眠呼吸障碍”)为关键词检索知网、万方,(“motor neuron disease”or“amyotrophic lateral sclerosis”or“progressive bulbar pa...
zh-cn
pair_30156066
Benign prostatic hyperplasia (BPH) is a common disease in the elderly population and holmium laser enucleation of the prostate (HoLEP) is an important method for its management. However, postoperative complications of HoLEP affects the patients' quality of life as well as the outcome of surgery. Based on the ten-year c...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
良性前列腺增生(BPH)是中老年男性的常见疾病,而钬激光前列腺剜除术(HoLEP)是解除增生前列腺组织的重要方法,但是术后的并发症仍然影响着患者生活质量与手术效果。我中心经过10年的临床实践和多中心的数据分析,针对接受HoLEP的患者提出了“尿道康复”的理念,主要包括术后的疼痛康复、排尿康复、控尿康复、性功能康复;建立了一套术后恢复程序,加速了患者术后康复。.
zh-cn
pair_30156067
To explore the feasibility and practicability of establishing a rat model of premature ejaculation (PE) by injection of 8-OH-DPAT into the subarachnoid space of the lumbosacral spinal cord segments. Twenty-four male Wistar rats were equally randomized into a PE model and a blank control group. The PE model was establis...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 探讨运用8-羟基-2-(二丙基氨基)四氢萘氢溴酸盐(8-OH-DPAT)腰骶脊髓节段蛛网膜下腔囊内注射建立早泄大鼠模型的可行性及实用性。方法: 选择雄性Wistar大鼠24只,按照1∶1随机分为2组,A组:空白对照组(等量生理盐水);B组:模型组[将8-OH-DPAT 溶于10 ml生理盐水中,按0.8 mg/(kg·d),进行腰骶脊髓节段蛛网膜下腔囊内注射,持续4周]。雌性Wistar大鼠24只,摘除卵巢后,于合笼前36 h皮下注射苯甲酸雌二醇20 μg以诱导雌性大鼠发情。在第2周和第 4周时,将雄性大鼠和激素诱导的雌性大鼠合笼,进行交配实验,每次30 min。观察和记录雄性大鼠的交配行为,包括骑跨潜伏期、插入潜伏期、射精...
zh-cn
pair_30156068
To elucidate the possible role of human lysozyme-like protein 4 (LYZL4) in fertilization and characterize its enzymatic properties. The localization of LYZL4 in human spermatozoa was investigated by immunofluorescence staining, the sources of LYZL4 on the sperm surface examined by RT-PCR, and the role of LYZL4 in ferti...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 对人源类溶菌酶蛋白4(LYZL4)在受精过程中的作用和重组蛋白的酶学性质进行研究,从而揭示LYZL4的生理功能。 方法: 细胞免疫荧光法检测LYZL4在精子细胞上的亚细胞定位, RT-PCR分析精子表面LYZL4的来源,通过精子穿透试验分析LYZL4在受精过程中的作用。构建真核重组表达载体pPIC9K-LYZL4,转化毕赤酵母GS115菌株后,甲醇诱导表达;甲壳素亲和层析和凝胶过滤层析从发酵上清中纯化重组LYZL4蛋白(rLYZL4),通过Western印迹进行验证。ELISA测定rLYZL4的透明质酸结合能力,分光光度法测定rLYZL4的胞壁质酶活性、透明质酸酶活性和自由基清除能力。 结果: LYZL4免疫荧光定位于成熟精...
zh-cn
pair_30156070
To investigate the success rate and safety of percutaneous vasoseminal vesiculography with the disposable vasographic interventional therapy kit (VITK). This study included ninety-six 19-65 (mean 43) years old male patients with infertility, hematospermia, seminal vesicle cyst, ejaculatory duct cyst, ejaculatory dysfun...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 评估一种经皮穿刺输精管介入治疗包用于输精管造影的成功率以及安全性。方法: 2016年10月至2017年4月采用开放、多中心、单组自身对照设计,纳入96例男性患者,年龄19~65岁,平均43岁,包括不育症、血精症、精囊囊肿、射精管囊肿、射精功能障碍、输精管损伤。患者均在局麻下应用穿刺包行输精管腔内注射造影剂并摄片。结果: 完成试验的患者94例,造影成功者92例,成功率97.9%。造影结果显示,精道异常率为54.3%(51/94)。28例不育患者中,双侧输精管梗阻3例,单侧梗阻5例。44例血精患者中,36例(81.8%)为精囊炎。13例射精功能障碍患者中,5例(38.5%)双侧输精管发育异常。2例因行双侧腹股沟疝修补术致输精管损...
zh-cn
pair_30156071
To explore the etiological factors for calculus-associated seminal vesiculitis by analyzing the composition of seminal vesicle calculus samples. This retrospective study included 6 cases of recurrent hematospermia diagnosed with seminal vesicle calculus by non-contrast pelvic CT. The patients were aged 28 to 69 years, ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 通过对精囊结石标本进行成分分析,初步探讨精囊结石患者的致病因素。方法: 回顾性分析6例反复血精且盆腔CT平扫提示精囊结石患者的临床资料。患者年龄28~69岁,持续或反复血精3个月至6年。6例中5例有急性尿道炎史。所有患者均接受精囊镜检查治疗术,术中证实精囊炎合并精囊结石,并以套石篮套取结石标本。利用第二代红外光谱结石成分分析仪分析6例精囊结石成分。随访患者2周至3个月,复查盆腔CT平扫观察有无生殖道结石复发。结果: CT平扫结果提示术后3个月有3例患者精囊结石复发,其中2例血精复发,其复发时间均在手术后1个月。6例精囊结石中有5例含有感染性结石成分——六水磷酸镁铵,仅有1例结石成分为二水草酸钙、一水草酸钙以及碳酸磷灰石的混合...
zh-cn
pair_30156072
To compare the safety and effectiveness of shovel-shaped electrode transurethral plasmakinetic enucleation of the prostate (PKEP) with those of plasmakinetic resection of the prostate (PKRP) in the treatment of benign prostatic hyperplasia (BPH). We retrospectively analyzed the clinical data about 78 BPH patients recei...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 探讨铲状电极经尿道前列腺等离子剜除术(PKEP)与经尿道前列腺等离子切除术(PKRP)治疗良性前列腺增生(BPH)的疗效和安全性。方法: 回顾性选取2016年6月至2017年1月收治的BPH患者78例,其中经铲状电极PKEP手术39例,经PKRP手术39例,对比分析两种手术方式的术后临床疗效及安全性。结果: 在安全性方面,同PKRP组相比,PKEP组患者手术时间无显著差异[(69.3±8.8) min vs (72.2±7.9) min, P=0.126],术后血红蛋白丢失量显著低于PKRP组[(3.9±2.8) g/L vs (13.9±5.2) g/L, P<0.01],PKEP组患者术后膀胱冲洗时间[(12.5±1.2...
zh-cn
pair_30156073
To explore the strategies of preserving urinary continence in transurethral plasmakinetic enucleation of the prostate (PKEP) for benign prostate hyperplasia (BPH). We treated 65 BPH patients by PKEP with preservation of urinary continence (UC-PKEP), which involved protection of the external urethral sphincter in the be...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 探讨经尿道前列腺等离子剜除术(PKEP)中保留尿控的策略及技巧。方法: 65例良性前列腺增生(BPH)患者,行保护尿控的PKEP,术中实施控尿策略,前(尿道精阜处):保护尿道外括约肌;中(尿道前列腺部):适当保留前列腺前叶,保护尿道内括约肌功能;后(尿道内口处):保留膀胱颈口完整性。比较同期54例行常规等离子完全前列腺剜除术患者的术后尿控情况。结果: 所有患者均顺利完成手术,术后5 d拔除尿管,完全剜除组和保留尿控剜除组的尿失禁发生率:拔尿管后24 h为31.49%和13.85%,拔除尿管后1周为18.52%和4.62%,拔尿管后2 周为14.81%和3.08%,两组间差异均有统计学意义(P<0.05)。术后1个月两组间尿失...
zh-cn
pair_30156074
The Prostate Cancer Prevention Trial risk calculator (PCPT-RC) is an online tool for assessing the risk of prostate cancer (PCa) based on age, race, serum PSA, biopsy history, family history, and other factors. This study aimed to investigate the value, sensitivity and specificity of the PCPT-RC 2.0 in assessing the ri...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 前列腺癌预防试验(PCPT) 风险计算器是结合年龄、种族、血清PSA水平、穿刺活检史、家族史等因子对罹患前列腺癌风险进行评估的在线工具。本研究使用PCPT风险计算器RC 2.0评价中国高危人群(高基线PSA、直肠指检阳性、影像学阳性)的前列腺癌风险,检验其敏感性、特异性。方法: 选择2010年5月至2016年2月具有罹患前列腺癌风险的高危患者916例,该组患者的特征:较高的血清PSA水平(PSA>3 μg/L)或直肠指检异常或前列腺影像学检查异常,均进行前列腺穿刺活检,由于部分患者的数据缺失,实际纳入本研究的患者共计622例。按照前列腺穿刺结果将患者分为前列腺癌组与前列腺穿刺活检阴性组,使用在线工具PCPT RC2.0对每例...
zh-cn
pair_30156075
To investigate the prevalence of Ureaplasma urealyticum (UU) infection in infertile men, its influence on routine semen parameters and the distribution of antisperm antibody (AsAb) and its types in infertile patients with UU infection. We detected the positive rate of UU infection, semen parameters, and the distributio...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 了解不育男性解脲脲原体(UU)的感染率,分析UU感染对常规精液参数的影响;探讨不育男性合并UU感染者抗精子抗体(AsAb)及其不同类型的分布。方法: 选取2016年4~11月就诊的男性不育患者662例,25例生育者为对照组,检测UU、精子质量参数和AsAb及其类型的分布情况。结果: 不育组(阳性率52.87%,350/662)较对照组(阳性率16.00%,4/25)UU感染率明显增高(χ2=11.68,P<0.05)。UU阳性不育组患者,精液量、精子总数、活动精子浓度、前向运动精子百分率,较对照组均明显减低(P均<0.05)。UU阳性不育组患者精浆总AsAb阳性率为43.4%,比UU阴性不育组的36.5%虽有所升高,但差异没...
zh-cn