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pair_26668439 | Global governance and market failures mean that it is not possible to ensure access to antimicrobial medicines of sustainable effectiveness. Many people work to overcome these failures, but their institutions and initiatives are insufficiently coordinated, led and financed. Options for promoting global collective actio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los fracasos de gobernanza mundial y de los mercados significan que no es posible garantizar el acceso a medicamentos antimicrobianos de efectividad sostenible. Muchas personas trabajan para solucionar estos problemas, pero sus instituciones e iniciativas no están lo suficientemente coordinadas, guiadas y financiadas. ... | es |
pair_26668439 | Global governance and market failures mean that it is not possible to ensure access to antimicrobial medicines of sustainable effectiveness. Many people work to overcome these failures, but their institutions and initiatives are insufficiently coordinated, led and financed. Options for promoting global collective actio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Глобальное управление и неэффективность рыночного механизма обуславливают невозможность обеспечения доступа к противомикробным препаратам с постоянной эффективностью. Многие люди занимаются решением этих проблем, однако они сталкиваются с недостаточным координированием, руководством и финансированием их учреждений и ин... | ru |
pair_26668440 | The health consequences of tobacco use are well known, but less recognized are the significant environmental impacts of tobacco production and use. The environmental impacts of tobacco include tobacco growing and curing; product manufacturing and distribution; product consumption; and post-consumption waste. The World ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 使用烟草对健康造成的后果已经众所周知，但是生产和使用烟草对环境产生的重大影响却鲜为人知。烟草对环境的影响包括：烟草种植和烘焙、产品制造和分销、产品消费和消费后产生的垃圾。世界卫生组织发布的《烟草控制框架公约》第 17 条和第 18 条中强调的环境问题主要适用于烟草农业。关于烟草生产和使用对环境造成的伤害，第 5.3 款中呼吁烟草行业采取政策干预来保护环境。我们将会详细探讨烟草在其生命周期内对环境造成的影响，同时建议政策应对。. | zh-cn |
pair_26668440 | The health consequences of tobacco use are well known, but less recognized are the significant environmental impacts of tobacco production and use. The environmental impacts of tobacco include tobacco growing and curing; product manufacturing and distribution; product consumption; and post-consumption waste. The World ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les conséquences du tabagisme sur la santé sont notoires. En revanche, les impacts environnementaux considérables de la production et de la consommation de tabac sont moins connus. Ces impacts environnementaux sont liés à la culture et au séchage du tabac, à la fabrication des produits du tabac et à leur distribution, ... | fr |
pair_26668440 | The health consequences of tobacco use are well known, but less recognized are the significant environmental impacts of tobacco production and use. The environmental impacts of tobacco include tobacco growing and curing; product manufacturing and distribution; product consumption; and post-consumption waste. The World ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Las consecuencias sanitarias del consumo de tabaco son bien conocidas, pero no tanto los significativos efectos que el cultivo y consumo de tabaco tienen en el medio ambiente. Los efectos medioambientales del tabaco incluyen el crecimiento y la cura del tabaco, la producción y distribución del producto, el consumo del ... | es |
pair_26668440 | The health consequences of tobacco use are well known, but less recognized are the significant environmental impacts of tobacco production and use. The environmental impacts of tobacco include tobacco growing and curing; product manufacturing and distribution; product consumption; and post-consumption waste. The World ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Влияние табака на здоровье изучено хорошо, но куда менее известно значительное воздействие производства и потребления табака на окружающую среду. Воздействие табака на окружающую среду происходит во время выращивания и сушки табака, изготовления, распределения и потребления табачных изделий; также влияние на окружающую... | ru |
pair_26668441 | Providing health care for children with congenital heart diseases remains a major challenge in low- and middle-income countries. In October 2011, the Government of Paraíba, Brazil, established a paediatric cardiology network in partnership with the nongovernmental organization Círculo do Coração. A cardiology team supe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在低收入和中等收入国家，为患有先天性心脏病的儿童提供医疗保健服务仍然是一项重大挑战。. 在 2011 年 10 月，巴西帕拉伊巴州政府与非政府组织 Círculo do Coração 合作，创立了儿科心脏病网络。心脏病学团队使用互联网与远程医疗设施保持联系，监督所有的网络活动。该网络制定出筛查心脏缺陷的协议。内科医生直接在心脏病专家的在线监督下完成超声波心动图；或者随后由心脏病专家审查检查的视频录像。心血管外科医生一周来州立儿科医院一次，进行心脏手术。. 在 2011 年之前，帕拉伊巴州没有具备组织性的项目来关怀患有心脏病的儿童。这经常导致错过或延误诊断，给孩子的健康带来不利的结果。. 从 2012 年至 2014 年，73751... | zh-cn |
pair_26668441 | Providing health care for children with congenital heart diseases remains a major challenge in low- and middle-income countries. In October 2011, the Government of Paraíba, Brazil, established a paediatric cardiology network in partnership with the nongovernmental organization Círculo do Coração. A cardiology team supe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Offrir une couverture médicale aux enfants atteints de cardiopathies congénitales reste un problème majeur dans les pays à revenu faible et intermédiaire. En octobre 2011, le gouvernement de l'État de Paraíba, au Brésil, a mis en place un réseau de cardiologie pédiatrique en partenariat avec l'organisation non gouverne... | fr |
pair_26668441 | Providing health care for children with congenital heart diseases remains a major challenge in low- and middle-income countries. In October 2011, the Government of Paraíba, Brazil, established a paediatric cardiology network in partnership with the nongovernmental organization Círculo do Coração. A cardiology team supe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Proporcionar atención sanitaria a los niños con cardiopatías congénitas sigue siendo uno de los principales desafíos en los países de ingresos bajos y medios. En octubre de 2011, el Gobierno de Paraíba, Brasil, estableció una red de cardiología pediátrica en asociación con la organización no gubernamental Círculo do Co... | es |
pair_26668441 | Providing health care for children with congenital heart diseases remains a major challenge in low- and middle-income countries. In October 2011, the Government of Paraíba, Brazil, established a paediatric cardiology network in partnership with the nongovernmental organization Círculo do Coração. A cardiology team supe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Обеспечение медико-санитарного обслуживания для детей с врожденными заболеваниями сердца остается одной из серьезных проблем в странах с низким и средним уровнем дохода. В октябре 2011 года правительство штата Параиба, Бразилия, создало сеть детской кардиологии в сотрудничестве с неправительственной организацией Círcul... | ru |
pair_24101779 | To describe mortality patterns in women older than 50 years in light of the growth, seen in almost all countries, in the absolute number of females in this age group and in the proportion of the female population comprising older women. National death record data and World Health Organization estimates of life expectan... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 根据50 岁以上年龄组妇女绝对数量以及由老年妇女组成的妇女人口所占比例的增长(几乎所有国家中都看到这种增长),说明此年龄组老年妇女的死亡率模式。 对50 岁以上妇女的国家死亡记录数据和世界卫生组织的预期寿命估计和死亡原因进行了分析。同时按原因对老年人的死亡率趋势做了预测。 在发达国家和发展中国家,老年妇女的主要死亡原因是心血管疾病和癌症。在有死亡登记数据的国家中,最近几十年心血管和(在较小程度上)癌症死亡率似乎有所下降,这种下降提高了50 岁人口的预期寿命。如果这种趋势保持下去,由于人口增长和老龄化,老年妇女的死亡数仍会有所增长。 由于人口老龄化和儿童及孕产妇死亡率的降低,预计在中低收入国家非传染性疾病(尤其是心血管疾病和癌症)导致... | zh-cn |
pair_24101779 | To describe mortality patterns in women older than 50 years in light of the growth, seen in almost all countries, in the absolute number of females in this age group and in the proportion of the female population comprising older women. National death record data and World Health Organization estimates of life expectan... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Décrire les modèles de mortalité chez les femmes âgées de plus de 50 ans, au vu de l'augmentation, observée dans presque tous les pays, du nombre absolu de femmes dans ce groupe d'âge et de la proportion de la population féminine composée de femmes âgées. Les données nationales de mortalité et les estimations de l'Orga... | fr |
pair_24101779 | To describe mortality patterns in women older than 50 years in light of the growth, seen in almost all countries, in the absolute number of females in this age group and in the proportion of the female population comprising older women. National death record data and World Health Organization estimates of life expectan... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Describir los patrones de mortalidad en las mujeres mayores de 50 años a la vista del crecimiento observado, en casi todos los países, tanto en el número total de mujeres de dicho grupo de edad como en la proporción de la población femenina de edad más avanzada. Se analizaron los datos nacionales de los registros de de... | es |
pair_24101779 | To describe mortality patterns in women older than 50 years in light of the growth, seen in almost all countries, in the absolute number of females in this age group and in the proportion of the female population comprising older women. National death record data and World Health Organization estimates of life expectan... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Описание структуры смертности среди женщин в возрасте старше 50 лет, в свете роста, наблюдаемого почти во всех странах в абсолютном количестве женщин этой возрастной группы и в пропорции части женского населения, которую составляют женщины пожилого возраста Были проанализированы данные национальных записей о смертях и ... | ru |
pair_24101780 | To understand better the current regional situation and public health response to cervical cancer and female breast cancer in the Americas. Data on cervical cancer and female breast cancers in 33 countries, for the period from 2000 to the last year with available data, were extracted from the Pan American Health Organi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 更好地了解美洲子宫颈癌和女性乳腺癌的当前地区形势和公共卫生响应。 从泛美卫生组织(PAHO)地区死亡率数据库中提取33 个国家2000 年到去年有关子宫颈癌和女性乳腺癌的可用数据并进行分析。使用泊松回归模型计算研究期间的死亡率变化(在所有国家中,人口少的国家以及时间序列死亡率数据波动大的国家除外)。还对PAHO有关非传染性疾病的国家能力调查的信息进行了分析。 巴哈马、特立尼达和多巴哥以及乌拉圭的乳腺癌死亡率相对较高,而萨尔瓦多、尼加拉瓜和巴拉圭子宫颈癌的三种死亡率都最高。某些国家(尤其是巴拉圭和委内瑞拉)这两种癌症的死亡率都较高。虽然在美洲子宫颈癌的死亡率一直呈下降趋势,在美洲地区仅有少数国家出现乳腺癌死亡率下降趋势。在参与PAHO... | zh-cn |
pair_24101780 | To understand better the current regional situation and public health response to cervical cancer and female breast cancer in the Americas. Data on cervical cancer and female breast cancers in 33 countries, for the period from 2000 to the last year with available data, were extracted from the Pan American Health Organi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Mieux comprendre la situation régionale actelle et la réponse des services de santé publique face au cancer du col de l'utérus et au cancer du sein sur le continent américain. Des données sur les cancers du sein et du col de l'utérus dans 33 pays, depuis l'année 2000 jusqu'à la dernière année de données disponibles, on... | fr |
pair_24101780 | To understand better the current regional situation and public health response to cervical cancer and female breast cancer in the Americas. Data on cervical cancer and female breast cancers in 33 countries, for the period from 2000 to the last year with available data, were extracted from the Pan American Health Organi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Entender mejor la situación regional actual y la respuesta por parte de la sanidad pública al cáncer de cuello uterino y de mama femenino en las Américas. A partir de la Base de datos de mortalidad regional de la Organización Panamericana de la Salud (OPS) se obtuvieron y analizaron los datos sobre el cáncer de cuello ... | es |
pair_24101780 | To understand better the current regional situation and public health response to cervical cancer and female breast cancer in the Americas. Data on cervical cancer and female breast cancers in 33 countries, for the period from 2000 to the last year with available data, were extracted from the Pan American Health Organi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Лучше понять текущую ситуацию в регионе и меры в области общественного здравоохранения по выявлению и лечению рака шейки матки и рака молочной железы у женщин в странах Америки. Из региональной базы данных о смертности Панамериканской организации здравоохранения (ПАОЗ) были взяты и проанализированы данные о раке шейки ... | ru |
pair_24101781 | To investigate risk factors for chronic noncommunicable diseases (NCDs) and their determinants in Chinese women. Data from the 2010 China Chronic Disease and Risk Factor Surveillance survey, comprising a nationally representative sample of women, were obtained to determine the prevalence of eight risk factors for chron... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 调查中国女性慢性非传染性疾病（NCD）的风险因素及其决定因素。 从2010 年中国慢性疾病和风险因素检测调查结果中获取包含全国女性具有代表性的样本数据，来确定慢性NCD的八个普遍风险因素：当前吸烟、酗酒、水果和蔬菜摄入量不足、身体缺乏运动、超重和肥胖、血压高、空腹血糖和血清总胆固醇高。估计每个女性风险因素的平均数。还使用有序逻辑回归调查独立人口统计和社会经济变量。 发现以下的因素普遍率：水果和蔬菜摄入量不足，51.7%；超重和肥胖，32.3%；血压高，29.7%；身体缺乏运动，18.3%；血清总胆固醇高，18.1%；血糖高，7.0%；当前吸烟，2.4%；酗酒，1.3%。每个女性的风险因素平均数是1.61；48.0%女性至少有两个风险... | zh-cn |
pair_24101781 | To investigate risk factors for chronic noncommunicable diseases (NCDs) and their determinants in Chinese women. Data from the 2010 China Chronic Disease and Risk Factor Surveillance survey, comprising a nationally representative sample of women, were obtained to determine the prevalence of eight risk factors for chron... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Analyser les facteurs à risque pour les maladies non transmissibles (MNT) chroniques et leurs déterminants chez les femmes chinoises. Des données de l'enquête de surveillance des maladies chroniques et des facteurs à risque de 2010 en Chine couvrant un échantillon de femmes représentatif à l'échelle nationale ont été c... | fr |
pair_24101781 | To investigate risk factors for chronic noncommunicable diseases (NCDs) and their determinants in Chinese women. Data from the 2010 China Chronic Disease and Risk Factor Surveillance survey, comprising a nationally representative sample of women, were obtained to determine the prevalence of eight risk factors for chron... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Investigar los factores de riesgo de las enfermedades crónicas no transmisibles (ENT) y sus factores decisivos entre las mujeres chinas. Se extrajeron los datos del Estudio sobre enfermedades crónicas y control de los factores de riesgo en China realizado en 2010, que incluye una muestra representativa a nivel nacional... | es |
pair_24101781 | To investigate risk factors for chronic noncommunicable diseases (NCDs) and their determinants in Chinese women. Data from the 2010 China Chronic Disease and Risk Factor Surveillance survey, comprising a nationally representative sample of women, were obtained to determine the prevalence of eight risk factors for chron... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Изучение факторов риска хронических неинфекционных заболеваний (НИЗ) и их детерминант у китаянок. Были собраны данные исследования эпиднадзора за хроническими заболеваниями факторами риска в Китае в 2010 году, включившего национально репрезентативную выборку женщин, с целью определения распространенности восьми факторо... | ru |
pair_24101782 | To validate Kalache & Kickbusch's model: namely, that functional capacity peaks in early adulthood, then declines at a rate dependent on fitness level until a 'disability threshold' is reached. Data came from the Australian Longitudinal Study on Women's Health, which followed three cohorts from 1996 to 2011: a young, a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 验证Kalache和Kickbusch的模型:即,机能性能力在成年早期达到高峰,然后按依赖于健身水平的速度下降,直至达到“残疾门槛”。 数据来自1996 至2011 年澳大利亚妇女健康纵向研究的三组样本:年轻、中年和老年组(分别在1973-78、1946-51 和1921-26 年代出生)。使用简表(36)健康调查测量身体机能(1-100 分)。残疾阈值是日常活动需要协助的老年女性的平均身体机能分数(62.8)。整个样本使用样条回归方法并按照基线身体机能五等分和体力活动水平建立年龄和身体机能之间关系的模型。 随着年龄的增长,机能下降加快:18-23 岁为0.05 年度单位(95% 置信区间,CI: -0.13 至0.22)(即,无下... | zh-cn |
pair_24101782 | To validate Kalache & Kickbusch's model: namely, that functional capacity peaks in early adulthood, then declines at a rate dependent on fitness level until a 'disability threshold' is reached. Data came from the Australian Longitudinal Study on Women's Health, which followed three cohorts from 1996 to 2011: a young, a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Valider le modèle de Kalache & Kickbusch, selon lequel la capacité fonctionnelle connaît un pic chez les jeunes adultes, puis diminue à une vitesse dépendant du niveau de forme physique jusqu'à ce qu'un «seuil d'incapacité» soit atteint. Les données proviennent de l'étude australienne longitudinale sur la santé des fem... | fr |
pair_24101782 | To validate Kalache & Kickbusch's model: namely, that functional capacity peaks in early adulthood, then declines at a rate dependent on fitness level until a 'disability threshold' is reached. Data came from the Australian Longitudinal Study on Women's Health, which followed three cohorts from 1996 to 2011: a young, a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Validar el modelo de Kalache y Kickbusch; a saber, que la capacidad funcional alcanza su punto máximo en la edad adulta temprana y disminuye luego a un ritmo que depende del nivel de condición física hasta alcanzar el 'umbral de la discapacidad'. Se tomaron los datos del Estudio Longitudinal Australiano sobre la salud ... | es |
pair_24101782 | To validate Kalache & Kickbusch's model: namely, that functional capacity peaks in early adulthood, then declines at a rate dependent on fitness level until a 'disability threshold' is reached. Data came from the Australian Longitudinal Study on Women's Health, which followed three cohorts from 1996 to 2011: a young, a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Проверить достоверность модели Калаша и Кикбуша (Kalache & Kickbusch), а именно, гипотезу, согласно которой функциональная активность достигает пика в раннем взрослом возрасте, после чего идет на убыль в темпе, зависящем от уровня физической подготовки, вплоть до достижения «порога инвалидности». Использовались данные ... | ru |
pair_24101784 | The health concerns of women in their mid-adult years - when the prime age of reproduction has passed - have been traditionally given little or no attention by health systems and donors, despite the heavy burden that diseases such as breast and cervical cancer impose on women and their families. The risk of sexually tr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 尽管乳腺癌和宫颈癌等疾病对妇女及其家庭带来沉重的负担，传统上卫生系统和捐助者对中年女性（已过了生殖黄金年龄）的健康问题关注甚少或毫无关注。性关系伴生的性病感染风险以及与妊娠相关的死亡风险和发病率早已被确认，并刺激主要的控制工作，最终取得积极成果。但是，对早期生活如何影响妇女成年健康的关注度远远不够。在所有发展中国家，死于乳腺癌和宫颈癌的妇女比其他类癌症都要多。在大多数亚洲和拉丁美洲国家以及一些美洲国家，这两种癌症的死亡数已经超过与妊娠相关的死亡数。现在需要集中精力尝试扭转这些流行病学趋势有五个令人信服的理由：(i) 乳腺癌和宫颈癌的负担很大，且在不断增加；(ii) 有可用的有效筛查和治疗；(iii) 研究正在产生新的知识；(iv) ... | zh-cn |
pair_24101784 | The health concerns of women in their mid-adult years - when the prime age of reproduction has passed - have been traditionally given little or no attention by health systems and donors, despite the heavy burden that diseases such as breast and cervical cancer impose on women and their families. The risk of sexually tr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les problèmes de santé des femmes au milieu de l'âge adulte (une fois passé le premier âge de la reproduction) ont traditionnellement bénéficié de peu d'attention ou ont été ignorés par les systèmes de santé et les donateurs, malgré le lourd fardeau que constituent les maladies, comme le cancer du sein et du col de l'u... | fr |
pair_24101784 | The health concerns of women in their mid-adult years - when the prime age of reproduction has passed - have been traditionally given little or no attention by health systems and donors, despite the heavy burden that diseases such as breast and cervical cancer impose on women and their families. The risk of sexually tr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los problemas de salud de las mujeres de mediana edad, una vez han pasado la plenitud de la edad reproductora, han recibido tradicionalmente poca o ninguna atención por parte de los sistemas sanitarios y donantes, a pesar de la gran carga que enfermedades como el cáncer de mama o de cuello uterino representan para las ... | es |
pair_24101784 | The health concerns of women in their mid-adult years - when the prime age of reproduction has passed - have been traditionally given little or no attention by health systems and donors, despite the heavy burden that diseases such as breast and cervical cancer impose on women and their families. The risk of sexually tr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Системами здравоохранения и организациями-донорами уделяется традиционно мало внимания охране здоровья женщин средних лет, уже миновавших основной репродуктивный возраст, несмотря на тяжелое бремя заболеваний, таких как рак молочной железы и рак шейки матки, накладываемое на женщин и их семьи. Риск инфекций, передаваем... | ru |
pair_24101783 | To assess differences between men and women in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan Africa. In September 2011, the PubMed and Web of Science databases were searched for community-based, cross-sectional studies providing sex-specific prevalences of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 评估撒哈拉以南非洲糖尿病、空腹血糖受损和糖耐量异常患病率的男女差异。 在2011 年9 月,搜索PubMed和Web of Science数据库,查找基于社区、提供撒哈拉以南非洲区域(即根据联合国对非洲国家的亚区分类:东非、中非和南非)居住的成年人当中三种研究状况中任一种状况的特定性别患病率的横断面研究。然后使用随机效果模型计算和比较患有各种病情的男女差别。 在所识别的36 个相关的横断面数据集的元分析中,较之女性,在男性中空腹血糖受损更常见(OR:1.56;95%置信区间,CI:1.20–2.03),而女性的糖耐量受损比男性更常见(OR:0.84;95% CI:0.72–0.98)。对于两性之间大致差不多(OR:1.01;95% ... | zh-cn |
pair_24101783 | To assess differences between men and women in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan Africa. In September 2011, the PubMed and Web of Science databases were searched for community-based, cross-sectional studies providing sex-specific prevalences of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Évaluer les différences entre hommes et femmes en termes de prévalence du diabète sucré, de la glycémie à jeun anormale et de l'intolérance au glucose en Afrique subsaharienne. En septembre 2011, on a recherché dans les bases de données PubMed et Web of Science des études communautaires transversales fournissant les pr... | fr |
pair_24101783 | To assess differences between men and women in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan Africa. In September 2011, the PubMed and Web of Science databases were searched for community-based, cross-sectional studies providing sex-specific prevalences of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Evaluar las diferencias entre hombres y mujeres respecto a la prevalencia de la diabetes mellitus, las alteraciones de la glucemia en ayunas y la intolerancia a la glucosa en África subsahariana. En septiembre de 2011, se realizaron búsquedas en las bases de datos de PubMed y Web of Science a fin de hallar estudios com... | es |
pair_24101783 | To assess differences between men and women in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan Africa. In September 2011, the PubMed and Web of Science databases were searched for community-based, cross-sectional studies providing sex-specific prevalences of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Оценить различия между мужчинами и женщинами в распространенности сахарного диабета, нарушенной гликемии натощак и нарушенной переносимости глюкозы в Африке южнее Сахары. В сентябре 2011 года был осуществлен поиск в базах данных PubMed и Web of Science территориальных поперечных исследований, предоставляющих данные в п... | ru |
pair_24101785 | In low- and middle-income countries, breast and cervical cancer have a poor prognosis, partly owing to barriers to treatment. To redress this situation, health systems must be strengthened. Pink Ribbon Red Ribbon (PRRR) is an innovative partnership designed to leverage public and private investments in global health an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在中低收入国家,乳腺癌和宫颈癌的预后较差,部分原因在于治疗的障碍。要纠正此问题,必须强化卫生系统。 粉红丝带红丝带(PRRR)是一种创新的合作关系,旨在利用全球卫生的公共和私人投资以及建立成功的艾滋病紧急救援计划(PEPFAR)平台,以应对撒哈拉以南非洲地区和拉丁美洲的乳腺癌和宫颈癌。PRRR旨在借助支持一整套全面的国有及国家推动的干预,通过计划减少经筛查和治疗的女性宫颈癌死亡人数,并通过促进早期检测减少乳腺癌死亡人数。 在初始阶段,PRRR支持博茨瓦纳、赞比亚和其他国家的政府扩大宫颈癌预防、筛查和治疗覆盖面(尤其是针对感染艾滋病毒的高风险妇女)并加强乳腺癌教育和控制服务。 PRRR在癌症控制中引入了一种基于生命历程和连续护理方法的... | zh-cn |
pair_24101785 | In low- and middle-income countries, breast and cervical cancer have a poor prognosis, partly owing to barriers to treatment. To redress this situation, health systems must be strengthened. Pink Ribbon Red Ribbon (PRRR) is an innovative partnership designed to leverage public and private investments in global health an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Dans les pays à revenus faible et moyen, les cancers du sein et du col de l'utérus ont un mauvais pronostic, notamment en raison des obstacles au traitement. Pour remédier à cette situation, les systèmes de santé doivent être renforcés. Le Pink Ribbon Red Ribbon (PRRR) est un partenariat novateur, conçu pour tirer part... | fr |
pair_24101785 | In low- and middle-income countries, breast and cervical cancer have a poor prognosis, partly owing to barriers to treatment. To redress this situation, health systems must be strengthened. Pink Ribbon Red Ribbon (PRRR) is an innovative partnership designed to leverage public and private investments in global health an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | En los países con ingresos medios y bajos, los cánceres de mama y de cuello uterino tienen un pronóstico desfavorable que se debe, en parte, a las barreras para el tratamiento. Para solucionar esa situación, es necesario fortalecer los sistemas sanitarios. El propósito de la innovadora asociación Pink Ribbon Red Ribbon... | es |
pair_24101785 | In low- and middle-income countries, breast and cervical cancer have a poor prognosis, partly owing to barriers to treatment. To redress this situation, health systems must be strengthened. Pink Ribbon Red Ribbon (PRRR) is an innovative partnership designed to leverage public and private investments in global health an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | В странах с низким и средним уровнем дохода заболевания раком молочной железы и шейки матки имеют плохой прогноз, отчасти из-за наличия барьеров для лечения. Для исправления этой ситуации требуется укрепить системы здравоохранения. Инновационное партнерство Pink Ribbon Red Ribbon (PRRR) предназначено для привлечения го... | ru |
pair_24101786 | Although it is highly preventable and treatable, cervical cancer is the most common and most deadly cancer among women in Rwanda. By mobilizing a diverse coalition of partnerships, Rwanda became the first country in Africa to develop and implement a national strategic plan for cervical cancer prevention, screening and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 虽然宫颈癌高度可防可治,但是对于卢旺达妇女却是最常见和最致命的癌症。 通过动员多样化的伙伴关系联盟,卢旺达成为非洲第一个制定和实施宫颈癌预防、筛查和治疗国家战略计划的国家。 卢旺达(一个人口1040 万的东非内陆国家)已作好准备来应对一批“高负担”非传染性疾病。在过去十年,该国对传染性疾病的综合反应已经使得过早死亡率急剧下降。 在2011–2012 年,卢旺达为227246 名女孩接种所有三剂人类乳头状瘤病毒(HPV)疫苗。在符合条件的女孩中,分别在2011 年和2012 年实现三剂疫苗93.2%和96.6%的覆盖率。该国还发起全国性的筛查和治疗方案,该方案基于使用醋酸的子宫颈目视检查、HPV DNA测试、冷冻治疗、电圈切除术和各种... | zh-cn |
pair_24101786 | Although it is highly preventable and treatable, cervical cancer is the most common and most deadly cancer among women in Rwanda. By mobilizing a diverse coalition of partnerships, Rwanda became the first country in Africa to develop and implement a national strategic plan for cervical cancer prevention, screening and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Bien qu'il soit possible de le prévenir et de le guérir, le cancer du col de l'utérus est le cancer le plus fréquent et le plus mortel chez les femmes au Rwanda. En mobilisant une coalition hétéroclite de partenariats, le Rwanda est devenu le premier pays d'Afrique à développer et à mettre en œuvre un plan stratégique ... | fr |
pair_24101786 | Although it is highly preventable and treatable, cervical cancer is the most common and most deadly cancer among women in Rwanda. By mobilizing a diverse coalition of partnerships, Rwanda became the first country in Africa to develop and implement a national strategic plan for cervical cancer prevention, screening and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El cáncer cervical se puede prevenir y tratar en gran medida; aun así, constituye el tipo de cáncer más común y mortal entre las mujeres de Rwanda. Rwanda se convirtió en el primer país de África en desarrollar e implementar un plan estratégico nacional para la prevención, la detección y el tratamiento del cáncer cervi... | es |
pair_24101786 | Although it is highly preventable and treatable, cervical cancer is the most common and most deadly cancer among women in Rwanda. By mobilizing a diverse coalition of partnerships, Rwanda became the first country in Africa to develop and implement a national strategic plan for cervical cancer prevention, screening and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Несмотря на наличие эффективных методов по профилактике и лечению рака шейки матки, это заболевание является одним из самых распространенных видов рака среди женщин в Руанде, которое наиболее часто приводит к летальному исходу. Проведя координацию деятельности союзов партнерских организаций, Руанда стала первой африкан... | ru |
pair_31726511 | Retrospective analysis of 18 cases of occupational acute 1, 2-dichloroethane (1, 2-DCE) poisoning. The results showed that all patients have the main manifestations such as dizziness, headache, unresponsiveness and other symptoms of nervous system damage; Brain CT showed varying degrees of diffuse white matter lesions.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 分析广州市职业病防治院收治的职业性急性1，2-二氯乙烷（1，2-DCE）中毒致中毒性脑病患者18例。以头晕、头痛、反应迟钝等神经系统损害症状为主要表现，头颅CT均表现为不同程度的弥漫性脑白质病变。头颅MRI表现为两侧大脑半球白质广泛受累，受累白质区域为T1WI低信号，T2WI高信号，T2-Flair高信号改变；腰椎穿刺检查脑脊液压力（262.5±48.39）mm H(2)O，经治疗脑脊液压力恢复平均时间（161.56±75.27）d。职业性急性1，2-DCE中毒所致中毒性脑病可表现为脑脊液压力持续异常，治疗中脑脊液压力下降缓慢；及早行头颅影像学和腰椎穿刺检查，有利于早期发现颅内压情况；脑脊液压力动态监测可对急性1，2-DCE中毒在长... | zh-cn |
pair_31729049 | To explore the conditions that contribute to justification of aggression against nurses. A 2 (aggressor distress as reflected in stressful behaviour: high vs. low) × 2 (target nurse's communication quality as reflected in provision of information and expression of caring: high vs. low) factorial design. Communication q... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨攻击护士行为的正当性条件。 设计: A 2(压力行为所反映的攻击者痛苦:高与低)×2(提供信息和关怀表达所反映的目标护士的沟通质量:高与低)因素设计。通过向一半受访者表达关怀,且为另一半受访者提供信息来研究沟通质量。 方法: 数据于2018年在线收集。受访者(N = 305)收到八个版本的假想片段中的一个。一半的参与者收到的是关于攻击者的痛苦和关怀,另一半提供的是攻击者的痛苦和信息。在读完这些小片段后,受访者报告他们 对攻击者行为和对目标护士的温暖感的态度。收集的其他数据包括特质共情(控制变量)、人口统计学变量和对操作检查的反应。数据用方差分析方法进行分析。 发现: 结果显示攻击者的痛苦及护士沟通质量对攻击合理性及对护士... | zh-cn |
pair_31729081 | Conservation and management of marine biodiversity depends on biomonitoring of marine habitats, but current approaches are resource-intensive and require different approaches for different organisms. Environmental DNA (eDNA) extracted from water samples is an efficient and versatile approach to detecting aquatic animal... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 海洋生物多样性的保护和管理依赖于对海洋生境的生物监测, 而目前的监测方法都属于资源密集型, 且对不同生物需要采取不同的方法。从水样中提取环境 DNA (eDNA) 是一种调查水生动物高效通用的方法。在海洋中, eDNA 的组成反映了区域精细空间尺度上动物群的情况, 但对于 eDNA 在更大尺度上调查海洋生物群落的有效性尚有待探究。本研究基于 eDNA 条形码技术在海水样品中的应用, 比较了卡塔尔和阿拉伯湾 (又称波斯湾) 海洋生境的脊椎动物组成, 以分析 eDNA 在大空间尺度上描述和分辨海洋生物群落的能力。我们通过物种累积分析估计了我们检测到的脊椎动物多样性。结果显示, 我们获得的 eDNA 序列来自包含 73 个科 191 个类... | zh-cn |
pair_31729081 | Conservation and management of marine biodiversity depends on biomonitoring of marine habitats, but current approaches are resource-intensive and require different approaches for different organisms. Environmental DNA (eDNA) extracted from water samples is an efficient and versatile approach to detecting aquatic animal... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | ADN Ambiental de Vertebrados Tomado del Agua Marina para Realizar Biomonitoreos de los Hábitats Marinos Resumen La conservación y el manejo de la biodiversidad marina depende del biomonitoreo de los hábitats marinos, pero las estrategias actuales requieren de muchos recursos y de diferentes estrategias para diferentes ... | es |
pair_31729768 | To identify the effects of each domain of the early and modified ABCDE bundle on post-intensive care syndrome (PICS). This is a retrospective study. We analysed the data from electronic medical records of 91 intensive care patients who received therapeutic interventions in stages, based on the early ABCDE bundle (admit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_31729771 | To test the effect of a teamwork enhancement and quality improvement program named 'Nurturing Effective Teams and Continuous Quality Improvement' on nurses' work environments in the hospital setting. Mixed-method study with quasi-experimental controlled trial and focus group interviews. Twelve units from two Philippine... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 在医院环境下,探讨‘培育高效团队及持续提高素质’的增强团队合作与素质提高计划对护士工作环境的影响。 设计: 准实验对照试验与焦点小组访谈相结合的混合方法研究。 方法: 将对来自菲律宾两所三级公立医院的12个单位进行将进行匹配和分配,让72名护士接受增强团队合作与素质提高计划,或不进行干预。该计划的重点是加强护士的自主性、领导力和管理支持、团队合作和工作量管理,分两个阶段进行:(a)使用团队战略和工具进行增强团队合作培训,从而提高护士的表现和患者安全;(b)实施素质提高项目,使用素质提高模型确定优先单元问题和变更思路,并进行计划-执行-研究-行动周期测试。此项目为期六个月,包括两次培训和七次的指导课程,以及一个素质提高指导老师... | zh-cn |
pair_31729809 | The increasing prevalence of antimicrobial resistance among bacteria in dogs with otitis externa has led to a need for novel therapeutic agents. To examine the antibacterial effects of manuka oil combined with ethylenediaminetetraacetic acid-tromethamine (Tris-EDTA) against Gram-negative bacteria isolates from dogs wit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 犬外耳炎中细菌耐药性增加,导致了对新型治疗药物的需求。 假设/目的: 研究麦卢卡油与乙二胺四乙酸-三甲胺(Tris-EDTA)联用对犬外耳炎中革兰氏阴性菌的抗菌作用。 方法和材料: 共有53种临床分离株,包括铜绿假单胞菌、大肠杆菌、肺炎克雷伯菌、肺炎支原体和变形杆菌。采用纸片扩散法进行药敏测试;研究有或无Tris-EDTA添加的麦卢卡精油的最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。 结果: 共有44株分离株对至少一种抗生素具有耐药性,且有19株具有多重耐药性,对三种或更多类型抗生素中的至少一种药物具有耐药性。单独使用麦卢卡油的MIC和MBC分别≥1%(v / v)和≥2%(v / v)。无麦卢卡油的Tris-EDTA(... | zh-cn |
pair_31729809 | The increasing prevalence of antimicrobial resistance among bacteria in dogs with otitis externa has led to a need for novel therapeutic agents. To examine the antibacterial effects of manuka oil combined with ethylenediaminetetraacetic acid-tromethamine (Tris-EDTA) against Gram-negative bacteria isolates from dogs wit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L'augmentation de la prévalence des résistances antimicrobiennes parmi les bactéries chez les chiens avec otite externe a mené à un besoin de nouveaux agents thérapeutiques. HYPOTHÈSES/OBJECTIFS: Examiner les effets antibactériens d'huile de manuka combiné avec le Tris-EDTA (ethylenediaminetetraacetic acid-tromethamine... | fr |
pair_31729809 | The increasing prevalence of antimicrobial resistance among bacteria in dogs with otitis externa has led to a need for novel therapeutic agents. To examine the antibacterial effects of manuka oil combined with ethylenediaminetetraacetic acid-tromethamine (Tris-EDTA) against Gram-negative bacteria isolates from dogs wit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die zunehmende Prävalenz der antimikrobiellen Resistenz bei Hunden mit Otitis externa hat dazu geführt, dass neue therapeutische Wirkstoffe benötigt werden. Eine Untersuchung der antibakteriellen Wirkung von Manukaöl in Kombination mit Ethylendiaminetetraacetic Säure-Tromethamine (Tris-EDTA) gegen Gram-negative Bakteri... | de |
pair_31729809 | The increasing prevalence of antimicrobial resistance among bacteria in dogs with otitis externa has led to a need for novel therapeutic agents. To examine the antibacterial effects of manuka oil combined with ethylenediaminetetraacetic acid-tromethamine (Tris-EDTA) against Gram-negative bacteria isolates from dogs wit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A crescente prevalência de resistência antimicrobiana em bactérias de cães com otite externa levou à necessidade de novos agentes terapêuticos. HIPÓTESE / OBJETIVO: Examinar os efeitos antibacterianos do óleo de manuka combinado com ácido etilenodiaminotetracético-trometamina (Tris-EDTA) contra bactérias Gram-negativas... | pt |
pair_31729809 | The increasing prevalence of antimicrobial resistance among bacteria in dogs with otitis externa has led to a need for novel therapeutic agents. To examine the antibacterial effects of manuka oil combined with ethylenediaminetetraacetic acid-tromethamine (Tris-EDTA) against Gram-negative bacteria isolates from dogs wit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la creciente prevalencia de resistencia a los antimicrobianos entre las bacterias en perros con otitis externa ha llevado la búsqueda de nuevos agentes terapéuticos. HIPÓTESIS/OBJETIVO: examinar los efectos antibacterianos del aceite de manuka combinado con ácido etilendiaminotetraacético-trometamina (Tris-EDTA) frente... | es |
pair_31729813 | Tolerance of Malassezia pachydermatis to azole drugs has been reported worldwide, from strains isolated from dogs. Canine Malassezia dermatitis often is treated with shampoos containing 2% miconazole (MCZ) or other topical MCZ products. In the in vitro study herein, it was investigated whether MCZ-induced amino acid su... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 从犬身上分离的厚皮马拉色菌对唑类药物的耐受性在世界范围内均有报道。用含2%咪康唑(MCZ)的香波或其他MCZ外用产品治疗犬马拉色菌性皮炎是常态。 目的: 在本文的体外研究中,研究了羊毛醇14-α-脱甲基酶(ERG11)基因1中MCZ诱导的氨基酸替代,是否会导致厚皮马拉色菌对唑类耐受。 方法和材料: 通过在含MCZ的培养基中培养对唑类药物敏感的菌株(CBS1879<sup>T</sup> ),诱导其对MCZ产生耐受性。 采用改良的肉汤微量稀释(BM)法评估对MCZ、克霉唑(CTZ)和伊曲康唑(ITZ)的抗真菌敏感性。 为了评估三种耐MCZ菌株的潜在耐药机制,对ERG11进行测序。 同时检查唑类耐药分离株中钙调磷酸酶抑制剂他克莫... | zh-cn |
pair_31729813 | Tolerance of Malassezia pachydermatis to azole drugs has been reported worldwide, from strains isolated from dogs. Canine Malassezia dermatitis often is treated with shampoos containing 2% miconazole (MCZ) or other topical MCZ products. In the in vitro study herein, it was investigated whether MCZ-induced amino acid su... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La tolérance de Malassezia pachydermatis aux azolés est rapportée de souches isolées du chien. Une dermatite à Malassezia canine est souvent traitée avec des shampooings contenant 2% de miconazole (MCZ) ou d'autres produits topiques avec MCZ. Dans cette étude in vitro, il a été étudié si les substitutions d'amino-acide... | fr |
pair_31729813 | Tolerance of Malassezia pachydermatis to azole drugs has been reported worldwide, from strains isolated from dogs. Canine Malassezia dermatitis often is treated with shampoos containing 2% miconazole (MCZ) or other topical MCZ products. In the in vitro study herein, it was investigated whether MCZ-induced amino acid su... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Toleranz von Malassezia pachydermatis zu Azol Medikamenten wurde für Stämme, die von Hunden isoliert worden waren, weltweit beschrieben. Die Malasseziendermatitis des Hundes wird häufig mit Shampoos behandelt, die 2% Mikonazol (MCZ) enthalten oder mit anderen topischen MCZ Produkten. In dieser in vitro Studie wurde... | de |
pair_31729813 | Tolerance of Malassezia pachydermatis to azole drugs has been reported worldwide, from strains isolated from dogs. Canine Malassezia dermatitis often is treated with shampoos containing 2% miconazole (MCZ) or other topical MCZ products. In the in vitro study herein, it was investigated whether MCZ-induced amino acid su... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A tolerância de Malassezia pachydermatis a medicamentos azólicos foi relatada em todo o mundo a partir de cepas isoladas de cães. A dermatite por Malassezia em cães geralmente é tratada com shampoos contendo 2% de miconazol (MCZ) ou outros produtos tópicos com MCZ. No presente estudo in vitro, investigou-se se as subst... | pt |
pair_31729813 | Tolerance of Malassezia pachydermatis to azole drugs has been reported worldwide, from strains isolated from dogs. Canine Malassezia dermatitis often is treated with shampoos containing 2% miconazole (MCZ) or other topical MCZ products. In the in vitro study herein, it was investigated whether MCZ-induced amino acid su... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | se ha informado sobre la tolerancia de Malassezia pachydermatis a los fármacos azólicos en todo el mundo, a partir de cepas aisladas de perros. La dermatitis por Malassezia canina a menudo se trata con champús que contienen 2% de miconazol (MCZ) u otros productos tópicos de MCZ. OBJETIVOS: en el estudio in vitro en est... | es |
pair_31734985 | Over 70% of hepatocellular carcinoma patients have not received traditional surgery because of their own disease characteristics and the limitations of traditional surgical methods. With the advancement of medical technology and the development of minimally invasive concepts, minimally invasive surgery, transcatheter a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 由于肝癌的自身疾病特性和传统手术方式的限制，有70%以上的肝癌患者未接受传统外科手术治疗。随着医学技术的进步和微创理念的发展，微创外科手术、经肝动脉化疗栓塞以及局部消融等微创治疗方式受到越来越多的重视。联合各类治疗方式的综合性治疗有助于强化各个治疗方式的自身特点，但综合治疗的指导标准尚有待进一步的探索和研究。. | zh-cn |
pair_31734986 | Currently, one-third of the world's chronic hepatitis B virus (HBV) carriers are in China. Therefore, it is important to develop treatment strategies that can accomplish virological suppression and improve clinical outcomes for China's huge HBV-infected population. Studies have shown that alanine aminotransferase (ALT)... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 中国当前的慢性乙型肝炎病毒（HBV）携带者占全球的三分之一。对于中国庞大的HBV感染人群，制定可达到病毒学抑制并改善临床预后的治疗策略至关重要。研究显示，丙氨酸转氨酶（ALT）水平与肝病进展和肝脏并发症的发生率显著关联，而ALT水平亦是决定是否开始抗HBV治疗的一项重要指标。临床上通常只在ALT水平高于2倍正常值上限时，才考虑开始抗病毒治疗。然而，ALT水平正常或低水平升高并不代表肝组织无变化。数项研究提示，ALT水平正常或低水平升高与肝病进展显著关联。如果把ALT水平高水平升高作为抗HBV治疗适应证的必要条件之一，许多患者可能会被忽略而延误治疗。这提示或许应考虑将抗HBV治疗的关口前移。现主要探讨ALT水平对抗HBV治疗的指导意义... | zh-cn |
pair_31734987 | Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in China. To provide evidence-based and updated practical recommendations for clinician, this expert recommendations have updated the diagnosis and treatment of NAFLD in five aspects as follows: (1) the framework of NAFLD treatment centre or clin... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 非酒精性脂肪性肝病（NAFLD）已成为我国最常见的慢性肝病。本建议从以下5个方面对NAFLD的规范化诊断和治疗进行了修订：（1）诊治中心/专病门诊的组织架构及功能；（2）筛查和评估：包括筛查对象、初步评估、病因筛查、非酒精性脂肪性肝炎（NASH）和进展性肝纤维化的无创诊断、肝活组织病理学检查以及代谢紊乱和心血管风险评估等；（3）临床处理：包括生活方式（饮食运动减重）调整，合并糖脂代谢紊乱、高血压等特殊人群的处理以及脂肪性肝炎和肝纤维化的药物选择；（4）特殊人群的管理：儿童、妊娠和哺乳期妇女、合并酒精性肝病、慢性HBV和/或HCV感染以及合并自身免疫现象等；（5）监测与随访。本建议旨在优化NAFLD患者的管理流程，指导临床医生制定更为... | zh-cn |
pair_31734999 | Presently, nonalcoholic fatty liver disease has become the most common pathogenic factor of chronic liver disease worldwide that can lead to the occurrence of hepatocellular carcinoma (HCC). Lipid metabolism in cancer cells is closely related to tumorgenesis, invasion and metastasis, and thus acts as one of the hallmar... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目前非酒精性脂肪性肝病已成为全球慢性肝病最常见的致病因素，并可导致HCC（HCC）的发生。脂代谢作为癌细胞的Hallmark之一，与肿瘤发生、发展、侵袭和转移等密切相关。脂质组学是代谢组学的重要分支，通过色谱和质谱技术，分析脂质成分的结构与功能，近年在HCC的研究中得到广泛应用。脂肪酸类、甘油脂类、甘油磷脂类、鞘脂类、固醇脂类等在HCC组织或血清中具有明显差异，有助于HCC的诊断、预后判定、机制研究以及靶向治疗等。. | zh-cn |
pair_31735000 | Portal vein thrombosis (PVT) is one of the serious complications in the decompensated stage of liver cirrhosis, which is often accompanied by the aggravation of liver cirrhosis and other complications and in severe cases; it may induce gastroesophageal variceal hemorrhage and endanger the lives of patients. Furthermore... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 门静脉血栓（PVT）是肝硬化失代偿期的严重并发症之一，常伴肝硬化病情的加重及其他并发症的产生，严重者可能会诱发食管胃静脉曲张破裂出血，危及患者的生命。而食管胃静脉曲张破裂出血是肝硬化失代偿期最常见的并发症，静脉曲张破裂出血史可能也是PVT形成的危险因素，两者可能是相互促进的。目前，肝硬化食管胃静脉曲张破裂出血已有诊疗指南，但对肝硬化并发PVT尚缺乏深入的认识，现就肝硬化食管胃静脉曲张并发PVT的危险因素及诊疗进展作一综述，从而增强对它的认识。. | zh-cn |
pair_31736124 | To examine the incidence of intraoperative peripheral nerve injury, symptoms, risk factors, functions, and quality of life in patients undergoing robotic-assisted laparoscopic surgery to lithotomy positioning with steep Trendelenburg. A systematic review. The Cochrane Library catalogue, PubMed, EMBASE, CINHAL and SveMe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究术中外周神经损伤的发生率,机器人辅助腹腔镜手术和特伦德伦伯格卧位取石定位患者的症状、危险因素、功能及生活质量。 设计: 系统评估。 数据来源: 通过Cochrane图书馆目录、PubMed、EMBASE、CINHAL和SveMed+数据库进行检索(从2000年1月至2019年2月)。 评估方法: 对文献标题和摘要进行筛选,查看是否符合纳入标准。由两名评估人员对每篇论文的全文内容进行评价。采用混合法评价工具对纳入的论文质量进行评估。采用描述性统计和专题分析来综合数据。 结果: 共纳入11项定量研究,包括三个主题:(a)术中外周神经损伤的发生率;(b)上肢术中外周神经损伤与特伦德伦伯格卧位定位的关系;以及(c)下肢术中外周神... | zh-cn |
pair_31736133 | To investigate workplace violence and nurse outcomes by comparing gender differences. A secondary analysis of cross-sectional survey data. Workplace violence was measured by four items from the International Hospital Outcome Study. Nurse outcomes were measured by tools including burnout, job satisfaction and intention ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 通过比较性别差异,探讨工作场所暴力与护士结局的关系。 设计: 横向调查数据的二次分析。 方法: 通过国际医院结局研究中的四个项目对工作场所暴力进行衡量研究。护士结局以工作倦怠、工作满意度和留任意愿为衡量指标。我们采用倾向性评分匹配,生成一个由108名男性护士和288名女性护士组成的社会人口平衡数据集。基于情绪事件理论提出了一个假设关系模型。通过利用好比较统计方法和多组结构方程建模来分析性别差异。数据于2013年12月至2014年8月在中国收集。 结果: 相比于女护士,男护士更容易遭受工作场所暴力,留任意愿较低。除了通过与女护士分享工作倦怠的调解作用(与情绪事件理论一致)外,工作场所暴力与男护士的留任意愿降低直接相关。 结论:... | zh-cn |
pair_31737911 | To characterize the clinical and genetic characteristics of a large cohort of patients with pyridoxine-dependent epilepsy (PDE). We retrospectively collected clinical and genetic information of 33 (15 males, 18 females; mean [SD] age 4y 11mo [2y 5mo]; 1y 3mo-10y 4mo) patients with PDE from 31 unrelated families at a si... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 总结33例吡哆醇依赖性癫痫（pyridoxine-dependent epilepsy, PDE）患者的临床特征及遗传学特点。 方法: 回顾性收集33例PDE患者的临床资料（15位男性，18位女性；平均年龄[SD]：4岁11个月[2岁5个月]；1岁3个月~10岁4个月), 所有患者均进行遗传学检测。 结果: 癫痫发作类型多样，32例患者出现局灶性发作。2例患者在未经遗传学确诊前临床疑诊为Dravet综合征。7例患者初次脑电图正常，随后，在吡哆醇维持治疗期间，17的患者脑电图恢复正常。基因检测结果提示有26种不同的ALDH7A1突变，4种PLPBP突变。其中，18种突变国际上未见相关报道。48个ALDH7A1突变位于外显子11... | zh-cn |
pair_31737969 | Canine pyoderma is a common skin infection caused predominantly by staphylococcal bacteria. Because of increasing rates of antimicrobial resistance in bacterial isolates, there is an urgent need for alternative or supplementary treatment options. W16P576, a Water Extract of Complex Mix of Edible Plants (WECMEP), has sh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 犬脓皮病是一种常见的皮肤感染,主要由葡萄球菌引起。由于细菌耐药性的增加,迫切需要替代或补充治疗方案。W16P576是多种食用植物混合水提取物(WECMEP),已报道其对多种细菌具有体外活性,包括假中间型葡萄球菌。建立犬脓皮病模型,其允许在受控环境中活体测试抗菌药物。 目的: 评估外用W16P576在犬脓皮病模型中的抗菌效果。 动物: 实验室饲养的九只比格犬。 方法和材料: 在一项8周洗脱期的评估者盲法交叉研究中,从细菌攻毒前三天开始,每天用W16P576 WECMEP或其载体对犬进行每天两次的外部治疗。在每只犬的身体两侧用两种浓度的临床假中间型葡萄球菌进行攻毒。持续外部治疗11天,14天时评估脓皮病的病变并打分。 结果: 所... | zh-cn |
pair_31737969 | Canine pyoderma is a common skin infection caused predominantly by staphylococcal bacteria. Because of increasing rates of antimicrobial resistance in bacterial isolates, there is an urgent need for alternative or supplementary treatment options. W16P576, a Water Extract of Complex Mix of Edible Plants (WECMEP), has sh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La pyodermite canine est une infection cutanée fréquente, principalement causée par les staphylocoques. En raison de l'augmentation des résistances antimicrobiennes des souches bactériennes, il y a un besoin urgent d'options thérapeutiques alternatives ou supplémentaires. W16P576, un WECMEP (Water Extract of Complex Mi... | fr |
pair_31737969 | Canine pyoderma is a common skin infection caused predominantly by staphylococcal bacteria. Because of increasing rates of antimicrobial resistance in bacterial isolates, there is an urgent need for alternative or supplementary treatment options. W16P576, a Water Extract of Complex Mix of Edible Plants (WECMEP), has sh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die canine Pyodermie ist eine häufige Hautinfektion, die vor allem durch Staphylokokkenbakterien verursacht wird. Aufgrund der zunehmenden antimikrobiellen Resistenz von Bakterienisolaten, besteht eine dringende Notwendigkeit für Alternativen und unterstützende Therapieoptionen. W16P576, ein wässriger Extrakt aus einem... | de |
pair_31737969 | Canine pyoderma is a common skin infection caused predominantly by staphylococcal bacteria. Because of increasing rates of antimicrobial resistance in bacterial isolates, there is an urgent need for alternative or supplementary treatment options. W16P576, a Water Extract of Complex Mix of Edible Plants (WECMEP), has sh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A piodermite canina é uma infecção cutânea comum causada predominantemente por bactérias estafilocócicas. Devido ao aumento da frequência de resistência antimicrobiana em isolados bacterianos, há uma necessidade urgente de opções de tratamento alternativas ou suplementares. O W16P576, um extrato aquoso de um mix comple... | pt |
pair_31737969 | Canine pyoderma is a common skin infection caused predominantly by staphylococcal bacteria. Because of increasing rates of antimicrobial resistance in bacterial isolates, there is an urgent need for alternative or supplementary treatment options. W16P576, a Water Extract of Complex Mix of Edible Plants (WECMEP), has sh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la pioderma canina es una infección cutánea común causada predominantemente por bacterias estafilocócicas. Debido al aumento de las tasas de resistencia a los antimicrobianos en aislamientos bacterianos, existe una necesidad urgente de opciones de tratamiento alternativas o complementarias. W16P576, un extracto acuoso ... | es |
pair_31738457 | The aim was to examine the reciprocal relationships of emotional labour strategies with emotional exhaustion and professional identity. This study adopted a four-wave cross-lagged panel design. Survey data were collected in 2018 from a sample of 171 newly hired nurses from 58 hospitals in 11 provinces of China. Nurses'... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究情绪劳动策略与情绪枯竭和职业认同的相互关系。 设计: 本研究采用四波交叉滞后组设计。 方法: 2018年,对我国11个省份58家医院的171名新聘护士进行问卷调查,收集数据。反复测量护士的情绪劳动(即深层伪装和表层伪装)、情绪枯竭和职业认同。采用交叉滞后组分析来检验我们先前假设的相互关系。 结果: 我们发现,情绪枯竭与表层伪装呈显著正相关(反之不成立);深层伪装与情绪枯竭呈显著负相关(反之不成立);职业认同与深层伪装呈显著正相关(反之不成立)。 结论: 我们的研究结果表明,深层伪装和职业认同可能会降低情绪枯竭的程度,而面临情绪枯竭的护士更有可能采用表层伪装策略。 影响: 本项研究发现将对护理管理工作产生影响。医疗保健管理... | zh-cn |
pair_31745327 | Posterior capsule opacification (PCO) is the most common complication following cataract surgery and affects millions of patients. PCO is a consequence of surgical injury promoting a wound-healing response. Following surgery, residual lens epithelial cells grow on acellular regions of the lens capsule, including the ce... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 后囊浑浊 (PCO) 是白内障术后最常见的并发症, 且影响着数百万患者。PCO是手术损伤后促进伤口发生愈合反应的结果。术后残余的晶状体上皮细胞在晶状体囊无细胞区域生长, 包括后囊中央区。这些细胞可发生纤维化改变, 从而使上皮细胞转分化为肌成纤维细胞, 并可能发生基质沉积和基质收缩, 这将会导致晶状体的光散射, 使许多病人需要更进一步的矫正措施—Nd: YAG激光后囊切开术。因此, 更全面地了解PCO是如何发生发展的和采取更好的措施来处理这些情况是极其重要的。为了实现这个实验, 系统是必须的, 且许多都可用于PCO的研究。虽然在不同物种中可能有许多与PCO相关的共同特点, 但控制情况的机制可以不同。因此在可能的情况下, 应采用... | zh-cn |
pair_31747113 | We comprehensively evaluated the association between husbands' smoking amount and wives' dysglycemia status. We conducted a cross-sectional study which recruited 12 023 714 reproductive couples who participated in the National Free Pre-Pregnancy Checkups Project (NFPCP) between 2015 and 2016 in China. Multivariable log... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 研究全面综合评估了丈夫吸烟与妻子血糖异常状态的关联性。 方法: 本研究采用横断面研究设计的方法, 选取在2015 至2016年期间参加全国免费孕前优生健康检查项目的12,023,714对备孕夫妇作为研究对象。采用多因素Logistic回归模型估计丈夫吸烟的相对危险度(Odds Ratio, OR)和95%置信区间(95% CI)。同时采用亚组分析和分层分析进一步探索潜在的修饰效应。 结果: 与丈夫和妻子均不吸烟组相比, 丈夫吸烟组、妻子吸烟组以及丈夫妻子均吸烟组中妻子糖尿病的患病率均较高, 经多因素校正后, 其OR值分别为1.09 (95% CI, 1.07-1.10), 1.04 (95% CI, 0.87-1.23)和1... | zh-cn |
pair_31755151 | Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions. The capacity of TLR 1-8 ligands (L) and of atopic cytokine milieu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 胸腺基质淋巴生成素(TSLP)在过敏性炎症发生过程中起关键作用。目前对马的TSLP表达的可能触发因素知之甚少。 假设/目的: 研究TSLP在马昆虫叮咬超敏反应(IBH)皮肤病变中的表达。在初代马角质细胞培养基中,研究TLR1-8配体(L)和异位性细胞因子环境作为TSLP的潜在触发因子,以及白介素(IL)-6作为TLR信号下游效应分子的能力。 动物: 采集IBH的病变皮肤和对照组马的健康皮肤(每组9例)作为样本。 方法和材料: 从六匹健康马身上制备角质细胞培养基,给予TLR1-8-L、IL-4和肿瘤坏死因子-α刺激,模仿异位性炎症细胞因子环境。实时荧光定量PCR检测TSLP和IL-6基因表达。 结果: 与健康皮肤相比,TSLP... | zh-cn |
pair_31755151 | Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions. The capacity of TLR 1-8 ligands (L) and of atopic cytokine milieu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Le TSLP (Thymic stromal lymphopoietin) joue un rôle clé dans le développement de l'inflammation allergique. On en sait peu sur les facteurs possibles d'expression de TSLP chez le cheval. HYPOTHÈSES/OBJECTIFS: Étudier l'expression de TSLP dans les lésions cutanées de l'hypersensibilité aux piqures d'insectes (IBH) chez ... | fr |
pair_31755151 | Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions. The capacity of TLR 1-8 ligands (L) and of atopic cytokine milieu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Das Thymic Stromal Lymphopoietin (TSLP) spielt eine Schlüsselrolle bei der Entwicklung allergischer Entzündung. Es ist wenig bekannt über die möglichen Auslöser der Exprimierung des equinen TSLP. Das Ziel war eine Untersuchung der TSLP Exprimierung in Hautveränderungen bei der Insektenstich Hypersensibilität des Pferde... | de |
pair_31755151 | Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions. The capacity of TLR 1-8 ligands (L) and of atopic cytokine milieu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A linfopoietina estromal tímica (TSLP) desempenha um papel fundamental no desenvolvimento da inflamação alérgica. Pouco se sabe sobre possíveis gatilhos da expressão de TSLP em equinos. HIPÓTESE/OBJETIVOS: Investigar a expressão de TSLP em lesões cutâneas de hipersensibilidade à picada de inseto (IBH) em equinos. A cap... | pt |
pair_31755151 | Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions. The capacity of TLR 1-8 ligands (L) and of atopic cytokine milieu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la linfopoyetina del estroma tímico (TSLP) desempeña un papel clave en el desarrollo de la inflamación alérgica. Poco se sabe sobre posibles desencadenantes de expresión de TSLP equina. HIPÓTESIS/OBJETIVOS: investigar la expresión de TSLP en lesiones cutáneas de hipersensibilidad por picadura de insecto en equinos (IBH... | es |
pair_32346111 | To systematically review studies of managing meibomian gland dysfunction (MGD) with azithromycin and pool clinical outcomes to show its effectiveness. Eligible studies were retrieved from five main electronic databases. Symptom score was the primary outcome, while clinical signs and objective measurements were secondar... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 已知• 睑板腺功能障碍 (Meibomian gland dysfunction, MGD) 是一种常见的眼表疾病, 以睑缘炎、霰粒肿和睑腺炎为特征, 为泪液蒸发过强性干眼综合征最常见的病因。• 大环内酯类抗生素已被证明治疗MGD有效, 但由于第一代大环内酯类抗生素严重副作用, 其临床应用受到限制• 阿奇霉素是第二代半合成大环内酯类抗生素, 具有半衰期长、眼内穿透性好、抗菌谱广等特点。本文探讨了• 本文对TA或OA治疗MGD的临床试验进行了系统回顾, 并通过汇集有关症状评分、临床体征及客观指标来总结结论。• 根据症状、体征及泪膜稳定性, 口服或外用阿奇霉素可有效治疗MGD, 其中眼局部应用阿奇霉素在改善泪膜质量方面优于口服阿... | zh-cn |
pair_32347053 | The ongoing outbreak of the coronavirus disease 2019 (COVID-19) as named by the World Health Organization has millions of confirmed cases around the world and has claimed hundreds of thousands of lives. The virus was named SARS-CoV-2 in February by International Committee on Taxonomy of Viruses. COVID-19 presents as fe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019 新型冠状病毒的暴发持续至今，导致了世界各地数以百万计的感染个例，更夺去了数十万人的生命。世界卫生组织在2020 年2 月将此病毒引起的疾病定名为2019 冠状病毒病 (Coronavirus disease 2019，COVID-19)，而国际病毒分类委员会也将此病毒命名为SARS-CoV-2。COVID-19 的典型临床症状类似感冒，少数病人可发展为重症甚至死亡。21 世纪以来，人类冠状病毒有3 次大暴发，分别是2003 年暴发的严重急性呼吸综合征(SARS)、2012 年暴发的中东呼吸综合征 (MERS) 和本次的新型肺炎。自2003 年以来，对SARS 和MERS 冠状病毒的研究从未间断，对其自然起源、致病机理、药物... | zh-cn |
pair_32347054 | An epidemic of acute respiratory syndrome in humans, which appeared in Wuhan, China in December 2019, was caused by a novel coronavirus (SARS-CoV-2). This disease was named as 'Coronavirus Disease 2019' (COVID-19). SARS-CoV-2 was first identified as an etiological pathogen of COVID-19, belonging to the species of sever... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 新型冠状病毒 (SARS-CoV-2) 是一种可引起人新型冠状病毒肺炎 (COVID-19) 的新发呼吸道病原体，与重症急性呼吸道综合症冠状病毒 (SARS-CoV) 和中东呼吸综合征冠状病毒 (MERS-CoV) 同属于β-冠状病毒，具有较高的传染性和一定的致死率。2019 年12 月在我国武汉被发现，随后蔓延到我国大部分省份，给我国人民健康和经济发展造成巨大损失。疫苗接种是预防和控制传染病的常规和有效手段，国内外多个机构已启动COVID-19 疫苗研究工作。文中基于SARS 和MERS 疫苗研究的经验和教训，对COVID-19 疫苗的研究策略和需要注意的关键问题进行了阐述，为相关研究人员提供参考。. | zh-cn |
pair_32347055 | Cyclophilin A (CypA) is a widely distributed and highly conserved protein in organisms. It has peptidyl-prolyl cis/trans isomerase activity and is a receptor for cyclosporin A (CsA). Coronaviruses are enveloped, single-stranded, positive-sense RNA viruses. Seven types of coronaviruses are currently known to infect huma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 亲环素 A (CypA) 是一种在生物界中广泛分布，并具有高度保守性的蛋白质，具有肽基脯氨酰顺/反异构酶活性，是免疫抑制药物环孢素A (CsA) 的细胞内受体。冠状病毒是具有包膜的、单股正链RNA 病毒，目前已知有7 种冠状病毒可以感染人类，其中包括致命的SARS-CoV、MERS-CoV 以及新型冠状病毒 (SARS-CoV-2)。已有研究表明，CypA 在SARS-CoV、CoV-229E、CoV-NL63 以及FCoV 等多种冠状病毒的复制中是必不可少的，而且CypA 的抑制剂CsA 及其衍生物 (ALV、NIM811 等) 对多种冠状病毒具有明显的抑制作用，暗示CypA 是潜在的抗冠状病毒药物靶点，CsA 这种老药有可能是一... | zh-cn |
pair_32347056 | Apomixis has been widely concerned because of its great potential in heterosis fixation. Artificial apomixis is an important direction of current apomixis research. Mitosis instead of Meiosis (MIME) produces diploid gametes that is identical with the maternal genetic composition and is a key step in the artificial crea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 无融合生殖因其在杂种优势固定中的巨大潜力而受到广泛关注，人工创制无融合生殖是当前无融合生殖研究的重要方向，有丝分裂替代减数分裂 (Mitosis instead of Meiosis，MIME) 能产生与母本遗传组成完全一致的二倍体配子，是人工创制无融合生殖的关键步骤。文中对MIME 的发生及其在作物无融合生殖中的应用以及MIME 应用中的问题进行综述，以期为扩大MIME 在作物无融合生殖中的应用提供参考。. | zh-cn |
pair_32347057 | Small interfering RNA (siRNA) has been used to treat various skin diseases. However, siRNA is limited in application due to its electronegativity, strong polarity, easy degradation by nuclease and difficulty in breaking through the skin barrier. Therefore, safe and efficient siRNA delivery vector is the premise of effe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 小干扰 RNA (Small interfering RNA，siRNA) 已被用于各种皮肤病的治疗。然而，由于siRNA 具有电负性、极性强、易被核酸酶降解以及难以突破皮肤表皮屏障等缺陷，使其应用受限。因此，安全高效的siRNA 递送载体是siRNA 有效治疗皮肤病的前提。近年来，随着对siRNA 研究的不断深入，基于脂质、聚合物、肽和纳米颗粒的递送系统的开发取得了很大进展，一些新的siRNA 透皮递送载体应运而生，如类脂质体、树枝状聚合物、细胞穿透肽、球形核酸纳米颗粒等等。文中将重点介绍近年来siRNA 透皮递送载体的最新研究进展。. | zh-cn |
pair_32347058 | Extracellular vesicles (EVs) refer to bilayer membrane transport vesicles secreted by cells. EVs can take macromolecules from cells and transfer them to receptor cells. Among these macromolecular substances, the most studied are microRNAs (miRNAs). miRNA is non-coding RNA involved in the regulation of gene expression. ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 细胞外囊泡 (Extracellular vesicles，EVs) 是指细胞分泌的双层膜转运囊泡。EVs 能从细胞中摄取大分子物质，并将其转移至受体细胞。在这些大分子物质中，研究最多的就是microRNA (miRNA)。miRNA 是一种参与基因表达调控的非编码RNA，已证实在哺乳动物卵泡液EVs 中有不同的非编码RNA 存在，EVs 携带miRNA 可以作为自分泌和旁分泌的替代机制，影响卵泡发育。文中系统介绍了EVs 的种类、特征和分离鉴定方法，重点综述了EVs 及携带的miRNA 对卵泡发育的作用，包括早期卵泡发育、卵母细胞成熟、卵泡优势化以及对颗粒细胞功能的影响。同时对卵泡液中EVs 及其携带的miRNA的未来研究进行了展... | zh-cn |
pair_32347059 | Cucumber (Cucumis sativus) is an important vegetable crop in the world. Agrobacterium-mediated transgenic technology is an important way to study plant gene functions and improve varieties. In order to further accelerate the transgenic research and breeding process of cucumber, we described the progress and problems of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 黄瓜Cucumis sativus 是世界性的重要蔬菜作物。农杆菌介导的转基因技术是研究植物基因功能及品种改良的重要手段。为进一步加快黄瓜的转基因研究和育种进程，文中针对农杆菌介导的黄瓜遗传转化方法，从黄瓜再生能力的影响因素、遗传转化条件和过程中各类添加物质等方面，阐述了根癌农杆菌介导的黄瓜转基因研究进展及存在的问题，并对提高黄瓜遗传转化效率和安全筛选标记的应用等前景进行了展望，以期为黄瓜抗逆育种和果实品质改良等研究提供参考。. | zh-cn |
pair_32347061 | Transcriptional factors play important roles in plant growth, development and responses to stresses. BBX transcriptional factors are characterized with one or two B-box domains in the protein sequence. They are comprehensively involved in photomorphogenesis, flowering, shade avoidance, signal transduction of phytohormo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 转录因子在调控植物生长、发育及环境适应性等方面发挥重要作用。具有B-box 结构域的一类锌指结构转录因子称为BBX，它们通过调控基因转录，与同类或其他转录因子的互作参与植物光形态建成、花发育、避荫效应、植物信号转导以及非生物和生物逆境响应等。文中从BBX 蛋白结构、分类以及其功能方面对该类转录因子在植物中的作用进行了综述。. | zh-cn |
pair_32347062 | As water-soluble, natural pigments, anthocyanins are responsible for the red, purple and blue colors of many flowers, which attract pollinators to spread pollen. The colors of flowers are also essential for plants to survive in the nature and become one of the most significant characteristics of ornamental plants. In t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 花色是植物吸引昆虫传播花粉的主要因素，对于植物在自然界的生存必不可少，也是观赏植物最重要的性状之一。在蓬勃发展的花卉产业中，色彩各异花卉的培育，可以弥补自然花色的匮乏，但是令人垂涎的蓝色花比较难培育。花色的多样性主要是由花青素及其衍生物的种类和含量等因素决定的，飞燕草色素的合成是形成蓝色花的关键因素，许多植物体内缺少合成飞燕草色素的结构基因。近年来，利用基因工程技术培育蓝色花的研究也时有报道。文中以常见的观赏植物为例，基于花青素代谢调控，从影响飞燕草色素合成的关键因素和不同分子改良途径培育蓝色花等几个方面对植物花朵呈色的机制进行了综述，并展示不同分子育种策略可能在其他领域的应用，为其他植物或经济作物的色泽改良如彩色棉蓝色纤维的培育等... | zh-cn |
pair_32347063 | To study the interaction between C4b-binding protein (C4BP) and Riemerella anatipestifer (RA), we cloned duck C4BPα, conducted prokaryotic expression and prepared the polyclonal antibody by immunizing mice. Then indirect immunofluorescence assay and dot blotting hybridization assay were used to verify the interaction b... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为研究鸭 C4 结合蛋白 (C4b-binding protein，C4BP) 与鸭疫里默氏菌 (Riemerella anatipestifer，RA) 的相互作用，对鸭C4BPα 进行克隆、原核表达，免疫小鼠制备多克隆抗体，并利用间接免疫荧光试验及斑点杂交试验验证C4BP 与RA 的相互作用。结果显示，鸭C4BPα 核苷酸序列全长为1 230 bp，与鸡C4BPα 的相似性最高 (82.1%)；系统进化树分析发现，鸭C4BPα 与鸡C4BPα 处于同一系统进化树分支上，两者遗传进化关系最近；C4BPα 在大肠杆菌Escherichia coli BL21 (DE3) 中能高效表达，重组蛋白以胞内可溶性形式存在；多克隆抗体效价超过... | zh-cn |
pair_32347064 | The responsibility of root is absorbing water and nutrients, it is an important plant tissue, but easily to be affected by biotic and abiotic stresses, affecting crop growth and yield. The design of a synthetic root-specific promoter provides candidate promoters for the functional analysis and efficient expression of s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 根负责吸收水分和养分，是重要的植物组织，但易受生物及非生物胁迫，影响作物的生长发育和产量。设计合成根特异启动子，可为与胁迫相关的抗性基因在作物根部的功能研究及高效表达提供候选启动子。文中将4 拷贝的根特异性顺式作用元件 (OSE1ROOTNODULE、OSE2ROOTNODULE、SP8BFIBSP8AIB 和ROOTMOTIFAPOX1) 以串联排列方式设计合成了一个根特异性模块 (pro-SRS)，并与来自CaMV 35S 启动子的最小启动子融合，合成一个人工合成启动子SRSP。通过替换CaMV 35S 启动子将SRSP 启动子克隆到pCAMBIA2300.1 中以驱动GUS 表达。将携带SRSP 启动子的构建体通过农杆菌介导的... | zh-cn |
pair_32347065 | OsRhoGDI2 was isolated as a putative partner of Rho protein family member OsRacD from rice panicles by yeast two-hybrid, but its function remains unknown. In order to identify the function of OsRhoGDI2, OsRhoGDI2 knockout mutants were created by CRISPR/Cas9 technology. The results showed that two different homozygous m... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | OsRhoGDI2 是通过酵母双杂交从水稻幼穗中分离的一个与Rho 蛋白家族成员OsRacD 相互作用蛋白的编码基因，但功能尚不明确。本研究利用CRISPR/Cas9 技术创制水稻OsRhoGDI2 基因敲除突变体。检测结果表明，转基因水稻T0 代获得2 种纯合突变体，T1 代获得8 种纯合突变体。序列分析显示，在敲除水稻中，该基因的编辑靶点附近发生了碱基的替换或缺失，预期生成丧失RhoGDI 保守结构域的截短蛋白。表型比对分析发现，敲除水稻与对照相比，株高显著降低，统计学分析结果显示，敲除水稻株高降低源于第Ⅱ和第Ⅲ茎节的缩短，提示OsRhoGDI2 基因可能与水稻株高控制相关。. | zh-cn |
pair_32347066 | Stearoyl-ACP Δ⁹ desaturase (SAD) catalyzes the synthesis of monounsaturated oleic acid or palmitoleic acid in plastids. SAD is the key enzyme to control the ratio of saturated fatty acids to unsaturated fatty acids in plant cells. In order to analyze the regulation mechanism of soybean oleic acid synthesis, soybean (Gl... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 硬脂酰-ACP Δ⁹ 脱氢酶 (Stearoyl-acyl carrier protein Δ⁹ desaturase，SAD) 在质体中催化单不饱和油酸或棕榈油酸的合成，是控制植物细胞饱和脂肪酸与不饱和脂肪酸比例的关键酶。为解析大豆油酸合成积累调控机制，文中对大豆Glycine max GmSAD 家族成员进行全基因组鉴定和保守功能域及理化性质等分析。应用qRT-PCR 检测GmSAD 各成员的时空表达谱，构建表达载体并通过农杆菌介导烟草Nicotiana tabacum 瞬时表达和油酸缺陷型酵母Saccharomyces cerevisiae 突变株BY4389 遗传转化测试GmSAD 酶活性和生物学功能。结果表明，大豆基因组含... | zh-cn |
pair_32347067 | We optimized a fluorescent quantitative polymerase chain reaction (qPCR) assay system for rapid and real time detection of SARS-CoV-2 RNA. The results show that the lowest dilution of RNA samples used for the detection of SARS-CoV-2 RNA could reach 1/10 000 (the initial value is set as 10 ng/μL). Moreover, the cycle th... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为实时并快速地检出SARS-CoV-2 冠状病毒RNA，对基于荧光定量聚合酶链式反应 (Polymerase chain reaction，PCR) 的反应体系进行了优化。结果表明，按照本实验提供的方法操作后，检测SARS-CoV-2 冠状病毒所用的RNA 样本的最小浓度稀释度可调至1/10 000 (初始值设为10 ng/μL)。且用于检测COVID-19 临床阳性样本所测得循环值 (Cycle threshold，Ct) 均低于35 或40。其灵敏性测试结果也表明该方法的敏感性较好。同时在同等条件下，与目前市场上的COVID-19 试剂盒的检测结果基本一致，并且检测循环数缩短2 个单位。因此，本实验所建立的体系适用于前期临床诊断... | zh-cn |
pair_32347068 | Immune cell infiltration is of great significance for the diagnosis and prognosis of cancer. In this study, we collected gene expression data of non-small cell lung cancer (NSCLC) and normal tissues included in TCGA database, obtained the proportion of 22 immune cells by CIBERSORT tool, and then evaluated the infiltrat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 免疫细胞浸润对癌症的诊断与预后有着重要意义。文中收集TCGA 数据库已收录的非小细胞肺癌肿瘤与正常组织基因表达数据，利用CIBERSORT 工具得到22 种免疫细胞占比来评估免疫细胞浸润情况。以22 种免疫细胞占比为特征，用机器学习方法构建了非小细胞肺癌肿瘤与正常组织的分类模型，其中随机森林方法构建的模型分类效果AUC=0.987、敏感性0.98 及特异性0.84。并且用随机森林方法构建的肺腺癌和肺鳞癌肿瘤组织分类模型效果AUC=0.827、敏感性0.75 及特异性0.77。用LASSO 回归筛选22 种免疫细胞特征，保留8 种强相关特征组成的免疫细胞评分结合临床特征构建了非小细胞肺癌预后模型。经评估及验证，预后模型C-index=... | zh-cn |
pair_32347069 | PEGylation is considered one of the most successful techniques to improve the characteristics of protein drugs including to increase the circulating half-life of proteins in blood and to decrease their immunogenicity and antigenicity. One known PEG modification method is to attach PEG to the free amino group, typically... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | PEG 修饰被认为是改善重组蛋白药物特性的最有效手段，包括增加蛋白质药物在体内的血浆半衰期，降低免疫原性和抗原性。目前典型的PEG 修饰手段为将PEG 连接至蛋白质的游离氨基，包括赖氨酸和N-末端，但这种连接缺乏选择性，产物为混合物，活性及工艺稳定性差，难以控制。酶法PEG 化修饰能有效克服上述缺点，其中谷氨酰胺转氨酶 (TGase) 可以作为PEG 化定点修饰用酶。文中选择重组人干扰素α2a (IFN α2a) 进行酶法修饰反应，通过计算机模拟预测IFN α2a 可以在第101 位Gln 特异性定点修饰。将IFN α2a 与40 kDa 的Y 型PEG 在微生物来源的谷氨酰胺转氨酶 (mTG) 催化下进行定点PEG 化修饰。结果显... | zh-cn |
pair_32347070 | The recombinant adenoviruses expressing miR-22 (Ad-miR-22) was constructed and the effect of Ad-miR-22 on insulin signal pathway and glucose uptake in HepG2 cells was analyzed. MiR-22 gene was amplified by PCR from human hepatocytes and cloned into the pAdTrack-CMV vector to generate the shuttle plasmid pAdT-22. The po... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 文中构建了miR-22 重组腺病毒Ad-miR-22，分析了其对HepG2 细胞胰岛素信号通路及葡萄糖摄取的抑制作用。通过PCR 方法，扩增了miR-22 的前体及侧翼序列，酶切后克隆至腺病毒穿梭载体pAdTrack-CMV 中，构建穿梭质粒pAdT-22，经PCR 及测序鉴定。穿梭质粒经PmeⅠ线性化后，直接转化含有腺病毒骨架载体的感受态细胞BJ5183，产生重组腺病毒质粒Ad-miR-22，最后经PacⅠ线性化后转染包装细胞系293A。重组腺病毒经过3 轮扩增后感染HepG2 细胞，通过荧光定量PCR 检测miR-22 表达水平。通过葡萄糖摄取实验观察Ad-miR-22对HepG2 细胞葡萄糖摄取的影响。采用Western bl... | zh-cn |
pair_32347071 | Rhus chinensis is an important economic species, which could provide raw materials for pharmaceutical and industrial dyes. Rhus chinensis is famous for its resistance to drought, cold, and salt. It grows in temperate, warm temperate, and subtropical regions. We report here Rhus chinensis chloroplast genomes by de novo ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 盐肤木是一种重要的经济树种，可为医药和工业染料提供原料。盐肤木具有较强的抗旱、耐寒、耐盐，可在温带、暖温带和亚热带地区生长。本研究首次对盐肤木叶绿体基因组进行从头测序 (de novo sequencing) 组装研究。结果表明，盐肤木叶绿体基因组长度为159 082 bp，具有典型的四部分结构，两个单拷贝区被一对反向重复区分隔。LSC 和SSC 的长度分别为85 394 bp 和18 663 bp。叶绿体基因组总共编码126 个基因，其中包括88个蛋白编码基因，8 个rRNA 基因，30 个tRNA 基因。在叶绿体基因组中，61.97%的序列为基因编码区。在盐肤木叶绿体基因组中，只有8 个基因含有内含子，除ycf3 基因 (2 个... | zh-cn |
pair_32347073 | Stomatal density is important for crop yield. In this paper, we studied the epidermal pattern factors (EPFs) related to stomatal development. Prokaryotic expression vectors were constructed to obtain EPFs. Then the relationship between EPFs and hydrogen sulfide (H2S) was established. First, AtEPF1, AtEPF2 and AtEPFL9 w... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 气孔密度是影响农作物产量的重要形态学指标。文中以拟南芥气孔发育相关的表皮模式因子 (EPFs) 为研究对象，构建原核表达载体并进行蛋白表达和纯化，并与新型气体信号分子硫化氢 (H2S) 建立联系。首先克隆基因AtEPF1、AtEPF2 和AtEPFL9，构建pET28a 表达载体；然后对重组质粒pET28a-AtEPF1、pET28a-AtEPF2和pET28a-AtEPFL9 进行酶切检测和测序，结果显示重组载体构建成功；分别转入大肠杆菌BL21(DE3) 进行异丙基β-D-硫代半乳糖苷 (IPTG) 诱导表达。优化后的表达条件：IPTG 诱导浓度分别为0.5、0.3、0.05 mmol/L；最适诱导温度分别为28 ℃、28 ℃和... | zh-cn |
pair_32347074 | Mutants of proteins are the basis for studying their structure and function, this work aimed to establish an efficient and rapid method for constructing multi-site mutants. When four or more adjacent amino acid residues need to be mutated, firstly, two long and two short primers (long primers Ⅰ/Ⅰ, short primersⅡ/Ⅱ) wer... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 蛋白质的突变体是研究其结构和功能的基础，文中旨在建立一种高效、快捷的多位点突变体构建方法。当要突变 4 个及以上相邻的氨基酸残基时，设计两长两短 (长引物Ⅰ/Ⅰ、短引物Ⅱ/Ⅱ) 4 条引物：长引物包含突变位点，且突变碱基数≤20 bp，短引物不包含突变位点；两条引物的GC 含量≤80%、退火温度之差≤40 ℃，分别以Ⅰ/Ⅱ和Ⅰ/Ⅱ两对引物和模板进行两组反向 PCR 扩增。扩增后各体系均可得到含有突变位点的非甲基化线性质粒，且以Ⅰ/Ⅱ和Ⅰ/Ⅱ为引物扩增得到的两组线性质粒的断开位点分布在突变位点两侧。用 DpnⅠ酶切回收后等摩尔比混合的PCR 产物除去甲基化模板，再进行一轮变性和退火处理，两组线性质粒在95 ℃变性后互相以来自对方的单链... | zh-cn |
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