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pair_32348597 | There is limited knowledge of the mechanisms that can inspire people's concern and engagement in the protection of unpopular and unappealing species. We analyzed Polish people's interest in themed internet memes featuring the proboscis monkey (Nasalis larvatus) and the consequences of this interest for conservation mar... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目前, 对于不受欢迎和无吸引力的物种如何引起人们关注及参与保护的机制仍不明确。本研究分析了波兰人对以长鼻猴 (Nasalis larvatus) 为主题的网络表情包的兴趣, 以及这种兴趣对保护营销的影响。我们利用了谷歌趋势数据, 用谷歌搜索了大众媒体材料, 以估计波兰人民对长鼻猴的兴趣。结果发现, 以幽默的形式出现长鼻猴照片的网络表情包能像非政府组织在保护营销中使用的其它更受欢迎的物种 (如考拉、熊猫、猩猩) 一样吸引人们的兴趣。社交媒体上传播的搞笑网络表情包与人们对长鼻猴等无吸引力物种的兴趣增加呈现正相关关系。此外, 人们对搞笑网络表情包的兴趣还与是否向 6 个众筹活动捐赠的决策呈正相关。因此, 包含搞笑表情包和社交媒体的保护营销... | zh-cn |
pair_32348597 | There is limited knowledge of the mechanisms that can inspire people's concern and engagement in the protection of unpopular and unappealing species. We analyzed Polish people's interest in themed internet memes featuring the proboscis monkey (Nasalis larvatus) and the consequences of this interest for conservation mar... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Efectos de los Memes Divertidos sobre el Interés por las Especies Poco Atractivas Resumen El conocimiento existente sobre los mecanismos que pueden incentivar el interés y la participación de las personas en la protección de especies poco populares y poco atractivas actualmente es limitado. Analizamos el interés del pu... | es |
pair_32352573 | Initial evidence suggests that gains in relationship functioning from brief, web-based programs are maintained through one year following the intervention; however, whether these results generalize to a low-income sample is unclear. Furthermore, previous research from in-person couple therapy suggests there may be diff... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 有初步的证据表明通过简短的基于网络的项目所获得的人际关系功能是可以持续保有的，时间跨度从开始到跟踪干预一年之后; 然而，这些结果是否适用于低收入人群还不清楚。此外，以前所作的是面对面的伴侣治疗研究，结果表明行为基础的方法技术和接受为基础的方法之间可能存在不同形状的维持斜率。本研究联系了668名参与者，他们参加了两个在线项目，一个是基于行为的(ePREP)，一个是基于接受的(OurRelationship)，这些参与者在项目完成一年后也接受跟踪调查。本研究使用了多水平模型来考察在线干预后一年中发生的变化其线性和二次曲面变化率，也考察从干预之前到12个月之后再跟踪随访期间的关系功能和个体功能的总变化量。 做出回应的伴侣中有大多数仍然与同... | zh-cn |
pair_32352573 | Initial evidence suggests that gains in relationship functioning from brief, web-based programs are maintained through one year following the intervention; however, whether these results generalize to a low-income sample is unclear. Furthermore, previous research from in-person couple therapy suggests there may be diff... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Las pruebas preliminares sugieren que los beneficios en el funcionamiento de las relaciones obtenidos de programas breves basados en la web se mantienen durante un año después de la intervención; sin embargo, no queda claro si estos resultados pueden generalizarse a una muestra de personas de bajos recursos. Además, in... | es |
pair_32356372 | While parental monitoring is understood to protect adolescents from engaging in risk behaviors, little is known about how the family dynamics involved in parental monitoring differ across sociocultural contexts. We sought to gain an in-depth understanding of parent-child relationship dynamics and parental knowledge of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 尽管父母监管被认为起到保护青少年不从事危险行为的作用，在父母监管之下的家庭动态在不同的社会文化背景下是不同的, 但是具体怎么不同人们却知之甚少。本研究试图深入了解在秘鲁的都市社区里家长和孩子之间的关系动态和父母对青少年活动的了解。这些社区的犯罪率高，青少年物质使用水平也都很高。我们对来自秘鲁卡亚奥的一所中学的青少年和他们的母亲进行了访谈，针对青少年的是15次深入访谈和2次焦点团体访谈，针对母亲的是12次深入访谈。我们的研究结果强调了亲子关系 confianza(信任)的重要性，这种信任是父母了解青少年的生活及其活动的基础。本次研究样本中的参与者认为confianza信任的特点是它鼓励了青少年坦诚交流打开自我，能影响到青少年如何解释父... | zh-cn |
pair_32356372 | While parental monitoring is understood to protect adolescents from engaging in risk behaviors, little is known about how the family dynamics involved in parental monitoring differ across sociocultural contexts. We sought to gain an in-depth understanding of parent-child relationship dynamics and parental knowledge of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Si bien existe una comprensión en relación a que la supervisión de los padres protege a los adolescentes de participar en comportamientos de riesgo, se sabe poco acerca de cómo la dinámica familiar involucrada en la supervisión difiere en distintos contextos socioculturales. Se buscó obtener una comprensión profunda de... | es |
pair_32362060 | Accurately quantifying species' area requirements is a prerequisite for effective area-based conservation. This typically involves collecting tracking data on species of interest and then conducting home-range analyses. Problematically, autocorrelation in tracking data can result in space needs being severely underesti... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 准确量化物种的栖息面积需求是开展有效区域保护的先决条件, 这一般包括收集目标物种的跟踪数据并进行家域分析。然而, 跟踪数据中的自相关性可能导致严重低估动物的空间需求。基于已有研究, 我们假设低估程度会随体重变化而变化, 这种关系可能对保护产生严重影响。为了评估陆生哺乳动物是否符合这一假设, 我们利用体重在 0.4 到 4000 千克之间的61种全球分布哺乳动物的 757 个个体的全球定位系统 (GPS) 定位数据, 估计了它们的家域范围。接下来, 我们应用分块交叉验证定量分析了家域经验估计的偏差。结果显示, 体重小于 10 千克的哺乳动物的面积需求平均被低估了约 15%, 体重在100千克左右的物种平均被低估约 50% 。因此, 我... | zh-cn |
pair_32362060 | Accurately quantifying species' area requirements is a prerequisite for effective area-based conservation. This typically involves collecting tracking data on species of interest and then conducting home-range analyses. Problematically, autocorrelation in tracking data can result in space needs being severely underesti... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Efectos del Tamaño Corporal sobre la Estimación de los Requerimientos de Área de Mamíferos Resumen La cuantificación precisa de los requerimientos de área de una especie es un prerrequisito para que la conservación basada en áreas sea efectiva. Esto comúnmente implica la recolección de datos de rastreo de la especie de... | es |
pair_32368194 | Risk factors for cancer-associated thrombosis are commonly divided into three categories: patient-, cancer-, and treatment-related factors. Currently, different types of drugs are used in cancer treatment. Chemotherapy has been identified as an independent risk factor for venous thromboembolism (VTE). However, it shoul... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 癌症相关性血栓形成的风险因素通常分为三类：患者相关、癌症相关和治疗相关因素。当前, 用于治疗癌症的药物多种多样。化学疗法已确定为静脉血栓栓塞 (VTE) 的独立风险因素。但必须注意, 各种细胞毒性药物产生 VTE 的风险并不一致。另外, 不同的支持性护理药物（如促红细胞生成刺激剂或粒细胞集落刺激因子）以及激素疗法可增加 VTE 风险。在过去的十年中, 免疫疗法和分子靶向疗法已大大改变了癌症的治疗方法。主要亚型包括酪氨酸激酶抑制剂、单克隆抗体、小分子和免疫调节剂。VTE 和靶向疗法之间的关系在很大程度上仍然未知. | zh-cn |
pair_32368194 | Risk factors for cancer-associated thrombosis are commonly divided into three categories: patient-, cancer-, and treatment-related factors. Currently, different types of drugs are used in cancer treatment. Chemotherapy has been identified as an independent risk factor for venous thromboembolism (VTE). However, it shoul... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los factores de riesgo para la trombosis asociada al cáncer se suelen dividir en tres categorías: factores relacionados con el paciente, con el cáncer y con el tratamiento. En la actualidad, existen distintos tipos de fármacos que se emplean en el tratamiento del cáncer. La quimioterapia se ha determinado como un facto... | es |
pair_32368195 | Neoatherosclerosis is defined as foamy macrophage infiltration into the peri-strut or neointimal area after stent implantation, potentially leading to late stent failure through progressive atherosclerotic changes including calcification, fibroatheroma, thin-cap fibroatheroma, and rupture with stent thrombosis (ST) in ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_32368195 | Neoatherosclerosis is defined as foamy macrophage infiltration into the peri-strut or neointimal area after stent implantation, potentially leading to late stent failure through progressive atherosclerotic changes including calcification, fibroatheroma, thin-cap fibroatheroma, and rupture with stent thrombosis (ST) in ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La neoateroesclerosis se define como infiltración de macrófagos espumosos en la zona periprotésica o de la neoíntima tras una implantación de stent, lo cual posiblemente derive en un fracaso tardío del stent mediante cambios ateroescleróticos progresivos, incluidos la calcificación, fibroateromas, fibroateromas de cáps... | es |
pair_32368197 | MicroRNAs (miRNAs) are small regulatory RNAs participating to several biological processes and known to be involved in various pathologies. Measurable in body fluids, miRNAs have been proposed to serve as efficient biomarkers for diseases and/or associated traits. Here, we performed a next-generation-sequencing based p... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 微小 RNA (miRNA) 是参与多种生物学过程的小型调节性 RNA, 已知参与各种病理过程。在体液中可测量的 miRNA 已被提议为疾病和/或相关性状的有效生物标记。我们在此对 344 名静脉血栓形成 (VT) 患者的血浆 miRNA 进行了基于下一代测序的分析, 并评估了血浆 miRNA 水平与几种止血性状和 VT 复发风险之间的关系。我们的重大发现之一是, 我们检测到 hsa-miR-199b-3p 与血细胞比容水平之间存在关联 (p = 0.0016), 这两个标志物均已被独立报道与 VT风险相关。我们还观察到了提示性的证据, 表明 hsa-miR-370-3p (p = 0.019)、hsa-miR-27b-3p (p ... | zh-cn |
pair_32368197 | MicroRNAs (miRNAs) are small regulatory RNAs participating to several biological processes and known to be involved in various pathologies. Measurable in body fluids, miRNAs have been proposed to serve as efficient biomarkers for diseases and/or associated traits. Here, we performed a next-generation-sequencing based p... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los micro-ARN (miARN) son pequeñas moléculas de ARN reguladoras que participan en varios procesos biológicos y están implicados en diversas patologías. Mensurables en los líquidos corporales, se ha planteado que los miARN pueden ser biomarcadores eficaces para el diagnóstico de enfermedades y/o características asociada... | es |
pair_32368198 | X-ray-based fluoroscopy is the standard tool for diagnostics and intervention in coronary artery disease. In recent years, computed tomography has emerged as a non-invasive alternative to coronary angiography offering detection of coronary calcification and imaging of the vessel lumen by the use of iodinated contrast a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基于 X 射线的荧光检查是诊断和干预冠状动脉疾病的标准工具。近年来, 计算机断层扫描已成为冠状动脉血管造影的一种非侵入性替代方法, 通过使用碘化造影剂来检测冠状动脉钙化和血管腔成像。即使当前可用的侵入性或非侵入性技术可以显示出血管狭窄的程度, 也仍无法提供有关生物功能性斑块特性（例如斑块炎症）的信息。此外, 辐射的使用和碘化造影剂的必要性仍然是不利的先决条件。磁共振成像是 X 射线的无辐射替代方法, X 射线提供了解剖学上和功能上的成像对比, 从而形成了对冠状动脉壁进行无创生物功能评估的想法。结合靶向血管壁特定表位的分子造影剂, MRI 可能会显示出独特的斑块特性, 例如“易损且易破裂”。这些病变的早期发现使在不良冠状动脉事件发生之... | zh-cn |
pair_32368198 | X-ray-based fluoroscopy is the standard tool for diagnostics and intervention in coronary artery disease. In recent years, computed tomography has emerged as a non-invasive alternative to coronary angiography offering detection of coronary calcification and imaging of the vessel lumen by the use of iodinated contrast a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La fluoroscopia con rayos X es la herramienta estándar para el diagnóstico y la intervención de coronariopatías. En los últimos años, la tomografía computarizada se ha convertido en una alternativa atraumática a la coronariografía, ya que se puede detectar la calcificación coronaria y ver a través de imágenes las luces... | es |
pair_32370461 | Multiple myeloma (MM) is a clonal plasma cell disorder, the second most hematological malignancy. MM mainly develops in elderly people and remains incurable at present. With the development of novel agents and advances of laboratory evaluation, the diagnosis and treatment of MM have been significantly improved. In this... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 多发性骨髓瘤（MM）是一种克隆浆细胞异常增殖的恶性疾病，在很多国家是血液系统第2位常见恶性肿瘤，多发于老年，目前仍无法治愈。随着新药不断问世及检测手段的提高，MM的诊断和治疗得以不断改进和完善。本次指南修订中增加了达雷妥尤单抗联合治疗部分及相关注意事项，在难治复发性MM部分增加了嵌合抗原受体T细胞免疫疗法，强调自体造血干细胞移植对于适合移植患者仍然具有不可替代的地位。. | zh-cn |
pair_32370466 | To investigate the early changes of peripheral blood leukocyte differential counts in patients with COVID-19. Ten patients with COVID-19 and 30 patients with other viral pneumonia (non-COVID-19) admitted to The Sixth People's Hospital of Shanghai and Jinshan Branch Hospital from January 22 to February 17, 2020 were enr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨新型冠状病毒肺炎（COVID-19）患者早期外周血白细胞分类特点。对2020年1月22日—2月17日上海市第六人民医院及其金山分院收治的10例COVID-19患者及同期收治的30例其他病毒导致的病毒性肺炎（非COVID-19）患者血白细胞分类进行分析。10例COVID-19患者白细胞计数为4.95（3.90，6.03）×10(9)/L，白细胞减少2例（2/10）；淋巴细胞绝对值为1.20（0.98，1.50）×10(9)/L，减少2例（2/10）；嗜酸性粒细胞绝对值0.01（0.01，0.01）×10(9)/L，减少7例（7/10）。与COVID-19组相比，30例非COVID-19患者白细胞计数8.20（6.78，9.03）×... | zh-cn |
pair_32370467 | To investigate how Chinese rheumatologists treated patients with rheumatoid arthritis (RA). We performed a survey on the choices of first-line and second-line anti-RA therapies, prescription of methotrexate and glucocorticoids, assessment of disease activity and frequencies of follow-up at the Asia Pacific League of As... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 旨在了解我国风湿科医生对类风湿关节炎（RA）治疗策略的认识情况。于2016年9月26—29日亚太风湿病学学会联盟上海会议上发放纸质调查问卷，调查参会医师治疗RA时一线和二线改善病情抗风湿药（DMARDs）的选择、生物制剂的选择、甲氨蝶呤与糖皮质激素应用及疾病活动度评估与监测频率。结果显示，治疗RA时，85.1%的医生首选甲氨蝶呤；存在甲氨蝶呤禁忌证时，71.0%的医生选择来氟米特或柳氮磺吡啶。当甲氨蝶呤治疗失败时，62.0%的医生选择换为或加用其他传统合成DMARDs，若选择应用生物制剂，65.2%的医生选择依那西普。97.3%的医生以甲氨蝶呤7.5~15 mg/周剂量起始；73.8%的医生使用最大甲氨蝶呤剂量为10~15 mg/周... | zh-cn |
pair_32372490 | Circulating anti-keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF-affected cats have been largely unsuccessful. To detect circulating anti-keratinocyte autoantibodies in PF-affected cats and deter... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 循环抗角质细胞免疫球蛋白 (Ig) G 靶向桥粒蛋白，已在落叶型天疱疮 (PF) 病人和患犬中确定。相比之下，在PF患猫中的检测尝试基本上未能实现。 假设/目的: 检测PF患猫中的循环抗角质细胞自身抗体，并确定其滴度和组织染色模式。 动物: 将30只PF患猫与11只无特定病原体、15只健康和31只过敏猫进行比较。 方法和材料: 通过间接免疫荧光法在犬爪垫和口腔粘膜基质上检测血清。 结果: 在大多数PF患猫 (23/30，77%)、一些过敏猫 (6/31，19%) 和1只健康猫 (7%) 中，检测到具有基底上、网状（细胞间）模式的循环抗角质细胞IgG。大多数血清阳性PF猫 (21/23，91%) 的爪垫表皮和口腔粘膜均为阳性，... | zh-cn |
pair_32372490 | Circulating anti-keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF-affected cats have been largely unsuccessful. To detect circulating anti-keratinocyte autoantibodies in PF-affected cats and deter... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les immunoglobulines circulantes anti-kératinocytes (Ig)G ciblant les protéines desmosomales ont été identifiées chez l’homme et le chien atteint de pemphigus foliacé (PF). En revanche, les essais de détection chez le chat ont été largement inefficaces. HYPOTHÈSES/OBJECTIFS: Détecter les auto-anticorps anti-kératinocyt... | fr |
pair_32372490 | Circulating anti-keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF-affected cats have been largely unsuccessful. To detect circulating anti-keratinocyte autoantibodies in PF-affected cats and deter... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Zirkulierende Anti-Keratinozyten Immunglobulin (Ig) G, die auf desmosomale Proteine abzielen, wurden bei Menschen und Hunden mit Pemphigus foliaceus (PF) identifiziert. Im Kontrast dazu waren Versuche, diese bei PF-erkrankten Katzen zu bestimmen, weitgehend erfolglos. Eine Bestimmung zirkulierender Anti-Keratinozyten A... | de |
pair_32372490 | Circulating anti-keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF-affected cats have been largely unsuccessful. To detect circulating anti-keratinocyte autoantibodies in PF-affected cats and deter... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Imunoglobulinas (Ig) G circulantes anti-queratinócitos direcionadas a proteínas desmossômicas foram identificadas em pessoas e cães com pênfigo foliáceo (PF). Por outro lado, as tentativas de detecção das mesmas em gatos afetados por PF não foram bem-sucedidas. HIPÓTESE/OBJETIVOS: Detectar auto-anticorpos anti-queratin... | pt |
pair_32372490 | Circulating anti-keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF-affected cats have been largely unsuccessful. To detect circulating anti-keratinocyte autoantibodies in PF-affected cats and deter... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | se han identificado inmunoglobulinas anti-queratinocitos (Ig) G circulantes dirigidas a proteínas desmosomales en personas y perros con pénfigo foliáceo (PF). Por el contrario, los intentos de detección en gatos afectados por PF no han tenido éxito. HIPÓTESIS/OBJETIVOS: Detectar autoanticuerpos anti-queratinocitos circ... | es |
pair_32372543 | Although evidence about skeletal muscle mass loss and type 2 diabetes risk has accumulated, little information is available on the combined effect of skeletal muscle mass and abdominal obesity on type 2 diabetes. We examined whether skeletal muscle mass and abdominal obesity were synergistically associated with the pre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 虽然关于骨骼肌肉质量的下降与2型糖尿病风险的证据已有研究, 但关于骨骼肌质量和腹型肥胖对2型糖尿病的联合作用的信息很少。我们研究了骨骼肌质量和腹型肥胖是否与2型糖尿病的患病率协同相关。 方法: 测量1515名40-69岁日本人的骨骼肌质量和腰围。相对肌量以总骨骼肌质量占体重的百分比(SMM%)计算。2型糖尿病被定义为空腹血糖≥7.0 mmol/L(126 mg/dL), 非空腹血糖≥11.1mmol/L(200mg/dL), 糖化血红蛋白≥6 5%, 且或正在使用糖尿病药物。 结果: 相对肌量最低的四分之一与最高四分之一相比, 男性及女性糖尿病患病率的多变量调整优势比(OR)都有所升高。较高腰围和糖尿病发病率之间的联系也是相... | zh-cn |
pair_30806047 | The 21st century is regarded as the century of biotechnological drugs, among which monoclonal antibodies and their derived targeting drugs have established themselves as the leading modality of biopharmaceutical pharmaceutics for a wide range of indications covering malignant tumors and autoimmune disorders. Since the ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 生物技术药物是21 世纪医药工业发展的中坚力量，其中单克隆抗体类药物是生物技术药物的典型代表，是恶性肿瘤、自身免疫病等领域全球销售额最高的药品种类。在抗体药物发展的几十年里，随着基因工程、蛋白质工程等领域的发展，抗体生产的宿主细胞建立、表达、纯化等各阶段的技术均不断取得突破，文中综述和讨论了抗体药物生产所采用的真核哺乳动物细胞表达系统、原核大肠杆菌表达系统、转基因动物反应器、无细胞蛋白质合成系统以及相关的关键技术进展。. | zh-cn |
pair_30806048 | Monoclonal antibodies have become the main type of antibody drug because of their high specificity and strong affinity to antigen. However, with the intensive study of the natural monoclonal antibody, many defects have faced, such as the limit times of binding to antigen, the unanticipated antibody clearance and antige... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 单克隆抗体因其与抗原结合具有高度特异性与强亲和力，已成为抗体药物研发的主要类型。但随着天然单克隆抗体的深入研究，它的诸多缺陷也浮出水面，如与抗原结合次数有限、带来非预期的抗体清除效应和抗原累积效应。人们不再局限于天然抗体的筛选，而是想通过改造提升抗体药物的药效。近年来，一类新型再循环抗体的问世，很好地解决了天然单克隆抗体发展的瓶颈。再循环抗体可以在胞外结合抗原，在细胞内与抗原解离，使抗体结合抗原次数最大化，减少抗原介导的抗体清除效应和抗体介导的抗原累积效应，并且再循环抗体可以通过进一步的Fc 改造来加强与Fc 受体的亲和力。文中综述了再循环抗体的研究进展，包括其特点、改造方法及展望。. | zh-cn |
pair_30806049 | Environmental protection and energy supply are our two major concerns. Greenhouse gases released from energy consumption have serious impact on the environment. CO₂ fixation can be used to convert CO₂ into fuels or chemicals. However, natural carbon-fixing organisms usually have some disadvantages such as slow growth a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 环境保护和能源供应是人类关心的两大问题。能源消耗释放出的温室气体对环境造成了严重影响。利用CO₂ 固定途径可将CO₂ 转化成燃料或化学品。天然固碳生物通常存在生长缓慢、固碳效率低等问题。通过在模式微生物中增强或重构CO₂ 固定途径，实现CO₂ 的再循环，可提高燃料或化学品的产量，减少温室气体排放。文中详细介绍了通过代谢工程手段改造CO₂ 固定途径改善化学品生产以及糖合成，阐述了相关代谢途径及其中的关键酶在CO₂ 固定中的作用，介绍了电生化合成系统的应用，显示出CO₂ 固定的巨大潜力，并展望了未来CO₂ 固定的研究方向。. | zh-cn |
pair_30806050 | Urease decomposes urea to ammonia, and has application potential in agriculture and medical treatment. Urease proteins include structural proteins (UreA, UreB and UreC) and accessory proteins (UreD/UreH, UreE, UreF and UreG), each of them has its own unique role in urease maturation. The structural proteins form the ac... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 脲酶能够催化尿素分解生成氨，在农业和医学领域中具有重要的意义。细菌脲酶蛋白包括结构蛋白(UreA、UreB 和UreC) 和辅助蛋白 (UreD/UreH、UreE、UreF 和UreG)，它们在脲酶活化过程中各自具有独特的作用，结构蛋白形成脲酶活性中心，而辅助蛋白主要负责镍离子的传递。文中综述了细菌脲酶蛋白复合物的结构和功能，以及各蛋白之间如何相互作用完成其活化过程，以期为脲酶活性调控研究及脲酶抑制剂开发等提供理论指导。. | zh-cn |
pair_30806052 | Pitch deposits have negative effects on product quality, machine performance and production line profitability during pulp and paper manufacture. As traditional pitch control technology cannot provide satisfactory solutions in the pitch deposits, the enzymatic treatment has been rapidly developed for its high efficienc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在制浆造纸过程中，沉积的树脂会影响纸浆和成纸质量，降低设备的运行效率，最终造成经济损失。由于传统控制树脂障碍的方法不能很好地解决这一问题，因此具有高效催化和无污染的特性的生物酶法在该方面得到快速发展。文中介绍了树脂的成分、存在形式和控制树脂障碍的生物酶，重点介绍了脂肪酶、甾醇酯酶、漆酶和脂氧合酶控制纸浆中树脂障碍的机理和工艺研究方面的进展，指出了生物酶控制树脂障碍技术目前存在的主要问题，提出了该领域的主要研究方向，并对生物酶控制树脂障碍技术进行了展望。. | zh-cn |
pair_30806053 | The study aims to use CRISPR/Cas9 introducing foreign gene targeted knock-in into chicken EAV-HP genome. First, specific primers were designed for amplification of EAV-HP left, right homologous arms and enhanced green fluorescent protein (eGFP) expression cassette. PCR products of homologous arms were ligated to both s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本研究旨在通过CRISPR/Cas9 介导外源基因靶向插入鸡EAV-HP 基因组。首先设计特异性引物并扩增鸡内源性病毒 (EAV-HP) 左右同源臂和增强型绿色荧光蛋白 (eGFP) 基因表达盒，然后通过重叠延伸PCR 技术将两个同源臂DNA 连接至eGFP 表达盒两侧，获得全长DNA 片段LER，并克隆至pMD19-T 载体，获得携带eGFP基因的供体载体pMDT-LER。随后在HEK293T 细胞中验证供体载体pMDT-LER 能成功表达eGFP 后，将EAV-HP打靶载体和供体载体共转染至DF-1 细胞，观察绿色荧光阳性细胞，提取细胞基因组，PCR 检测外源基因eGFP成功整合至鸡基因组EAV-HP 位点。最后，将转基因细胞D... | zh-cn |
pair_30806054 | Natural lignocellulosic materials contain cellulose, hemicellulose, and lignin. Cellulose hydrolysis to glucose requires a series of lignocellulases. Recently, the research on the synergistic effect of lignocellulases has become a new research focus. Here, four lignocellulase genes encoding β-glucosidase, endo-1,4-β-gl... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 天然的木质纤维素材料含有纤维素、半纤维素和木质素等成分。降解天然木质纤维素底物时，需要木质纤维素酶共同作用。近年在木质纤维素酶的相互协同作用方面的研究引起人们的关注，成为一个新的研究热点，文中使用两个不同的共表达载体pETDuet-1 和pRSFDuet-1，在大肠杆菌中共表达了白蚁及其肠道微生物来源的β-葡萄糖苷酶、内切β-1,4-葡聚糖酶、漆酶和木聚糖酶这4 种木质纤维素酶，经过SDS-PAGE 分析得到了与理论值一致的蛋白条带，同时经过酶活验证，这4 种蛋白都具有酶活性。以磷酸处理的微晶纤维素 (PASC) 为底物，测定了共表达酶粗酶液与单独表达酶混合液的协同作用因子，从还原糖的产量上经计算共表达的粗酶液比单独表达酶的混合液对... | zh-cn |
pair_30806055 | Escherichia coli was metabolically engineered to produce poly(glycolate-co-lactate-co-3-hydroxybutyrate) using glucose and xylose as carbon sources. The combinatorial biosynthetic route was constructed by the overexpression of a series of enzymes including D-tagatose 3-epimerase, L-fuculokinase, L-fuculose-phosphate al... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 以大肠杆菌为宿主，构建了以葡萄糖和木糖为底物获得乙醇酸、乳酸和3-羟基丁酸共聚酯的生物合成途径，包括过表达塔格糖-3-差向异构酶、核酮糖激酶、醛缩酶、醛脱氢酶、丙酰辅酶A 转移酶、β-酮硫解酶、乙酰乙酰辅酶A 还原酶和聚合酶等。在此基础上，表达聚羟基脂肪酸酯颗粒结合蛋白，提高了聚合物的合成，重组菌的细胞干重达到3.73 g/L，含有38.72 wt%的共聚酯。采用混菌共培养策略，实现以葡萄糖和木糖混合物为底物合成共聚酯，摇瓶实验中细胞干重达到4.01 g/L，含有21.54 wt%的聚合物。文中提供了一种以葡萄糖和木糖混合物为碳源合成聚合物的方法，为下一步纤维素水解物的有效利用提供了参考。. | zh-cn |
pair_30806056 | DNA methylation is an important type of epigenetic modification in eukaryotes. In order to research genome-wide methylation levels and patterns in foxtail millet (Setaria italica), the Methylation Sensitive Amplified Polymorphism (MSAP) analysis (employing double digestion with EcoR I and Hpa II/Msp I) was established ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | DNA 甲基化是真核生物一种重要的表观修饰形式。为了探讨谷子基因组DNA 胞嘧啶甲基化的水平和模式，以谷子 Setaria italica 的两个品种朝谷 58 号和豫谷 1 号为实验材料，利用 EcoRⅠ和 HpaⅡ/MspⅠ双酶切建立适合于谷子基因组的甲基化敏感扩增多态性 (MSAP) 分析体系。结果表明，从100 对MSAP 选扩引物中，筛选出32 对MSAP 引物组合，在朝谷58 号和豫谷1 号中分别扩增产生1 615、1 482 条清晰可辨且可重复的DNA 条带，其中包括3 种类型的甲基化条带，朝谷58 号和豫谷1 号的基因组中CCGG序列胞嘧啶甲基化水平分别为6.93%和8.77%。这种谷子不同品种间甲基化水平和分布位点... | zh-cn |
pair_30806057 | Creating new germplasms and breeding new cultivars in peanut by radiation mutagenesis and tissue culture were conducted in this study, aiming to develop new breeding method of peanut. Mature seeds from Luhua 11, the most commonly grown peanut cultivar in Northern China, were treated by fast neutron irradiation. Then th... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为开拓新的花生育种方法，对辐照诱变结合组织培养创造花生新种质、培育新品种进行了研究。以我国北方地区主栽花生品种鲁花11 号成熟种子为试材，经快中子辐照处理后取种子胚小叶进行组织培养，通过胚胎发生途径获得再生苗。再生苗经嫁接驯化后移栽田间，83 个单株获得种子。后代按系谱法进行选育，从83 个再生植株后代中获得了107 份突变体，分别在主茎高、分枝数、荚果形状和大小、种皮颜色、内种皮颜色、含油率、蛋白含量等性状上发生了明显变异。从突变体后代中选育出了低油早熟耐涝大花生新品种宇花7 号，其产量比亲本鲁花11 号增产14%以上；其含油率 (47.0%) 比鲁花11 号低5.1 个百分点。宇花7 号2016 年参加辽宁省新品种登记试验，比对... | zh-cn |
pair_30806058 | In previous studies, we found that truncated rotavirus VP4* (aa 26-476) could be expressed in soluble form in Escherichia coli and confer high protection against rotavirus in the mouse mode. In this study, we further improved the immunogenicity of VP4* by polymerization. The purified VP4* was polymerized through incuba... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在前期工作中发现，截短的轮状病毒VP4*蛋白 (aa 26–476) 在大肠杆菌中能够以可溶形式表达，且在小鼠模型中具有较高的免疫原性和免疫保护性。本研究通过颗粒化进一步提高VP4*蛋白的免疫保护性。通过37 ℃水浴加热处理24 h 使VP4*蛋白多聚化，通过高效液相色谱、透射电镜、分析超离等分析VP4*蛋白颗粒化程度，通过酶联免疫吸附试验分析颗粒化对VP4*蛋白与中和抗体反应性的影响；通过差示量热法分析VP4*高聚体的热稳定性；最后，通过小鼠母传抗体模型研究颗粒化对VP4*免疫原性和免疫保护性的影响。结果表明，VP4*蛋白高聚体结构均一，并且相比三聚体，具有更高热稳定性和中和抗体结合活性；在内毒素<20 EU/mg 的条件下，与铝... | zh-cn |
pair_30806060 | The aim of the study was to obtain the secondary metabolites in the stem segment of noni and to establish genetic transformation system. The stem segments (no axillary buds) of noni were used as explants to induce the callus, and then to establish the cell suspension system. The factors affecting callus induction and c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为获取诺丽茎段中的次生代谢物并为建立遗传转化体系奠定基础，以诺丽茎段(无腋芽)为外植体诱导愈伤组织，并建立细胞悬浮系，对影响愈伤组织的诱导及细胞悬浮系的因子进行了研究。结果表明：愈伤组织诱导的最优培养基是MS+1.0 mg/L 6-BA+0.1 mg/L 2,4-D；悬浮培养的最佳培养基为MS+1.0 mg/L 6-BA+0.1 mg/L 2,4-D+3%蔗糖，pH 为 5.85，当初始接种量为 37.5 g/L、摇床转速为 110 r/min 且 (25±2)℃ 暗培养时，悬浮细胞生长良好，生长速率最大；诺丽茎段悬浮细胞生长曲线呈“S”型，最适继代周期为12–20 d；培养过程中，培养基的pH 呈先下降后缓慢升高的变化趋势，诺丽茎... | zh-cn |
pair_30806061 | We explored the improved method to prepare decellularized kidney scaffold and provide experimental basis for kidney tissue engineering and renal pathology and toxicology in vitro research. We perfused rat kidneys with PBS (group control) and prepared the decellularized kidney scaffolds with sodium dodecyl sulfate (SDS)... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本研究旨在探索优化肾脏脱细胞支架的制备方法，为肾脏组织工程及肾脏体外病理、毒理研究提供实验基础。取大鼠肾脏灌注PBS 作为对照组 (Control 组)，在不同流速下分别以十二烷基磺酸钠 (Sodium dodecyl sulfate，SDS) 灌注 (S 组)，Triton X-100 联合SDS 灌注 (TS 组)，反复冻融后Triton X-100 联合SDS 灌注(FTS组)，制备肾脏脱细胞支架，并测定其流体分布及脉管阻力。HE 染色、DAPI 染色、DNA 定量检测脱细胞支架脱细胞程度，Masson 染色、PAS 染色、免疫组织化学染色检测脱细胞支架主要成分的保留和结构的完整，扫描电镜检测支架的超微结构，MTT 法检测支架... | zh-cn |
pair_30806062 | This study aimed to obtain a recombinant human-source collagen for industrialization. First, based on the Gly-X-Y sequence of human type I collagen, we optimized the hydrophilic Gly-X-Y collagen peptide, designed the human collagen amino acid sequence and the corresponding nucleotide sequence. Next, the expression vect... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为了获得可实现工业化生产的重组人源性胶原蛋白，根据人I 型胶原蛋白Gly-X-Y 序列，优选亲水性的Gly-X-Y胶原肽段设计人源性胶原蛋白氨基酸序列及对应的核苷酸序列，利用酶切技术构建pPIC9K-COL 表达载体，电转化毕赤酵母获得人源性胶原蛋白毕赤酵母工程菌，并对其进行发酵罐发酵、纯化及鉴定。结果显示，获得表达量达4.5 g/L，纯度大于95%的人源性胶原蛋白，经氨基酸N 端测序、分子量测定、氨基酸分析及胶原酶降解试验，确定获得的蛋白与理论的人源性胶原蛋白一级结构一致；同时胶原经冷冻干燥后进行扫描电镜分析及细胞毒性试验，确定人源性胶原蛋白冻干品具有多孔纤维网状结构及优良的细胞相容性，预示其具备作为生物医学材料的潜质。. | zh-cn |
pair_30806063 | Nowadays, available phosphorus (P) deficiency in soil and weed resistance to herbicides have emerged as two severe limiting factors for sustainable agriculture. Therefore, it is of urgent needs to improve plant absorption/utilization ability of the soil P, seek phosphate (Pi)-alternative P fertilizers, and develop new ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 磷是植物生长发育所必需的大量营养元素之一。土壤中存在大量的正磷酸盐 (Pi)，但由于土壤化学和微生物转化使得土壤可利用磷的浓度并不高。土壤缺磷以及杂草的抗除草剂能力已成为当前农业可持续发展的重要限制因素，所以提高植物对土壤磷的吸收利用能力或寻求可替代正磷酸盐的磷肥以及开发新型杂草控制系统已成为亟待解决的问题。自然界中亚磷酸盐 (Phi) 是含量仅次于正磷酸盐的磷源，但仅在某些细菌中能被专一性的亚磷酸盐脱氢酶 (PTDH) 氧化利用，对植物的生长发育则具有抑制作用。利用这一特性，将从土壤宏基因组中直接扩增到的假单胞菌PTDH 基因PsPtx 通过农杆菌侵染法转入烟草中，并通过RT-PCR、垂直板幼苗生长、显性标记和生长竞争实验分析Ps... | zh-cn |
pair_30809885 | To investigate the ultrasound characteristics and outcome of fetuses with non-visualization of the fetal gallbladder (NVFGB) followed in our tertiary university hospital, and to provide a comprehensive review of the literature on prenatal findings and outcome of NVFGB. NVFGB was defined as non-visualization of the gall... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 妊娠中期超声检测未显示胎儿胆囊:队列研究和产后预后文献的系统回顾 目标: 探讨我校三级附属医院随访中发现的胎儿胆囊未显影(NVFGB)的超声特点和预后，全面回顾NVFGB产前检查结果及预后的相关文献。 方法: NVFGB是指一周内进行的两次靶向超声检测中发现胆囊未显影。首先，回顾了我们中心在过去9年里负责管理的NVFGB病例的医疗记录。然后系统回顾了相关文献，鉴定NVFGB的相关研究。评估了分离和非分离的NVFGB胎儿的染色体异常、胆囊后期显影、胆囊发育不全、胆囊纤维化和胆道闭锁的发生率。还回顾了肝酶测定在NVFGB胎儿胆囊纤维化和胆道闭锁诊断中的作用。 结果: 我们中心随访了16例NVFGB病例，其中10例(62.5%)为孤立性发... | zh-cn |
pair_30809885 | To investigate the ultrasound characteristics and outcome of fetuses with non-visualization of the fetal gallbladder (NVFGB) followed in our tertiary university hospital, and to provide a comprehensive review of the literature on prenatal findings and outcome of NVFGB. NVFGB was defined as non-visualization of the gall... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | No visualización de la vesícula biliar fetal en la ecografía del segundo trimestre del embarazo: estudio de cohortes y revisión sistemática de la literatura sobre el resultado postnatal OBJETIVOS: Investigar las características ecográficas y los resultados de los fetos con no visualización de la vesícula biliar fetal (... | es |
pair_30811593 | The purpose of this article is to introduce the Family Resilience Inventory (FRI) and present findings on initial efforts to validate this measure. The FRI is designed to assess family resilience in one's current family and in one's family of origin, enabling the assessment of family protective factors across these gen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 家庭韧性量表主要是为了测试某人所在的现有家庭和原始家庭的韧性而编制的,也旨在对有几代人的家庭其具体保护因素的测量。韧性量表的研发是基于多年来对东南部美洲原始土著人部落的人物志研究。我们也相信这个量表同样适用于其他多种背景的各色家庭。家庭韧性量表的测量项目来自于对有436名参与者的质性研究的数据的主题分析,共生成了20多个项目的测量。被研究的2个部落的127名参与者中,有8个案例的数据不完全,故而分析样本只有119个。研究结果是家庭韧性量表有两个因素组成,也即测量家庭韧性的明显维度 (具体就是现有家庭和原生家庭的韧性)。验证性因子分析的结果支持了假想的双因子结构(X<sup>2</sup> (644) = 814.14, p = .0... | zh-cn |
pair_30811593 | The purpose of this article is to introduce the Family Resilience Inventory (FRI) and present findings on initial efforts to validate this measure. The FRI is designed to assess family resilience in one's current family and in one's family of origin, enabling the assessment of family protective factors across these gen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El propósito de este artículo es presentar el “Inventario de Resiliencia Familiar” (FRI, por sus siglas en inglés) y los resultados actuales sobre los primeros esfuerzos para validar esta medición. El FRI está diseñado para evaluar la resiliencia familiar en la familia actual de una persona y en la familia de origen de... | es |
pair_30811594 | Noxious family environments are associated with a wide range of adverse child outcomes. In order to prevent couple and parent-child relationship problems, a number of programs have been developed for couples with newborns. The current paper describes a program of research evaluating the American version of couple CARE ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在美国,低收入拉美裔人群在 心理健康状况方面的差距其影响涉及面很广。近来复苏的反移民形势让拉美裔移民经历了巨大的社会环境压力,也对他们的整体健康产生了多种有害的后果,包括对他们为人父母养育孩子方面的行为也有重大的破坏作用。尽管父母训练(PT)预防干预有很多好处,但是在这种比较不利的大环境下,面向社会福利照顾不到的拉美裔移民社群的人而采取的在具体情境和特定的文化下的相关父母干预措施还很少见。这篇论文旨在通过介绍GenerationPMTO这种实证为基础的模式来填补这方面知识的空白。这个模式在推广应用过程中已经根据所适用的文化做了调整。在以低收入拉美裔移民家庭父母作为研究对象的实证研究中,针对他们的文化作调适后发展出来的模式在应用过程中... | zh-cn |
pair_30811594 | Noxious family environments are associated with a wide range of adverse child outcomes. In order to prevent couple and parent-child relationship problems, a number of programs have been developed for couples with newborns. The current paper describes a program of research evaluating the American version of couple CARE ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los latinos de bajos recursos están expuestos a amplias desigualdades relacionadas con la salud mental en los Estados Unidos. Recientemente, un resurgimiento de relatos antiinmigratorios han llevado a los inmigrantes latinos vulnerables a sufrir considerables factores desencadenantes de estrés contextual con varias con... | es |
pair_30815912 | Leading societies toward a more sustainable, equitably shared, and environmentally just future requires elevating and strengthening conversations on the nonmaterial and perhaps unquantifiable values of nonhuman nature to humanity. Debates among conservationists relating to the appropriateness of valuing ecosystems in t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 要引导社会走向一个更加可持续、公平共享和环境公正的未来, 需要更多地探讨自然对人类非物质的、难以量化的价值。然而, 保护主义者关于对生态系统的人类利用价值进行评估是否合理这一问题的争论, 掩盖了一项更重要、更有影响力的任务, 那就是从不同利益相关者的角度提出保护关注的问题。本文讨论了全球范围内对生物社会复合体 (即地球上所有生命的相互关系和相互作用) 多种多样的观点, 并指出人类进行有效保护的最佳机会就是采取多元化的方法, 认真对待所有利益相关者的世界观。许多世界观, 特别是一些本土文化的世界观, 认为精神和非物质方面的价值比西方国家保护政策的论述更有意义。这种考虑自然内在价值的生物社会复合体替代框架, 或能成为社会变革和区域性保护... | zh-cn |
pair_30815912 | Leading societies toward a more sustainable, equitably shared, and environmentally just future requires elevating and strengthening conversations on the nonmaterial and perhaps unquantifiable values of nonhuman nature to humanity. Debates among conservationists relating to the appropriateness of valuing ecosystems in t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Adopción de Diferentes Cosmovisiones para Compartir el Planeta Tierra Resumen Para poder llevar a las sociedades hacia un futuro sustentable, compartido equitativa y ambientalmente justo se requiere elevar y fortalecer las conversaciones sobre los valores no materiales y probablemente imposibles de cuantificar que la n... | es |
pair_30816565 | To synthesize current knowledge about the impact of safety briefings as an intervention to improve patient safety. Improving safety in health care remains an ongoing challenge. There is a lack of evidence underpinning safety enhancing interventions. Mixed method multi-level synthesis. Four health literature databases w... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 综合目前有关将安全简报作为改善患者安全状况的干预措施等影响。 背景: 设计: 采用混合法,实现多级合成。 数据来源: 2002年1月至2017年3月间,共对四大健康文献数据库进行文献检索(Cinahl、Medline、Scopus以及Health Business Elite)。 评估方法: Thomas和Harden两位作者都采用混合法,实现多级合成。 结果: 完成质量评估之后,共开展了12项研究。其中,研究目的、研究方法和研究结果均存在显著的异质性。研究结果表明,安全简报的发布可产生有益的效果,并可同时改善安全文化。结果包括:风险识别性能改善、失败率降低、关系增进、事件报告数量增加、表达担忧能力的获取以及住院时间的缩短。... | zh-cn |
pair_30816567 | To review both mental and physical health consequences of bullying for healthcare employees. Systematic literature review. EMBASE, MEDLINE, PsycINFO, PUBMED and Web of Science Core Collection were searched for articles published between 2005 - January 2017. This review was conducted using the framework described by Kha... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 评价欺凌行为对医护人员身心健康的影响。 设计: 系统性文献评价。 资料来源: 对EMBASE、MEDLINE、PsycINFO、PUBMED以及科学网核心库上2005年至2017年1月期间发表的文章进行了检索。 综述方法: 本次评价使用Khan所描述的框架进行,并且,使用首选报告项目进行系统性评价和荟萃分析。两位独立评价人员进行了系统的数据提取,并对所纳入文章的方法学质量进行了评估。估算了欺凌行为的总体平均盛行率。 结果: 45篇论文符合纳入标准。欺凌行为的盛行率在3.9%-86.5%之间,总体平均估算值为26.3%。认识到欺凌行为与心理健康问题(包括心理压力、抑郁和倦怠)以及身体健康问题(包括失眠和头痛)相关。受欺凌的员工... | zh-cn |
pair_30816569 | The gap between research and clinical practice leads to inconsistent decision-making and clinical audits are an effective way of improving the implementation of best practice. Our aim is to assess the effectiveness of a model that implements evidence-based recommendations for patient outcomes and healthcare quality. Na... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究与临床实践之间的差距导致决策出现分歧,临床审计是改进实施最佳实践的有效方法。我们的目标对一个模型的有效性进行评估,该模型能给患者的治疗结果和医疗质量提供有据可循的建议。 设计: 国家准实验、多中心,前后对照研究。 方法: 本研究的研究对象为接受初级护理和医院护理单位护理及相关社会保健服务的患者。本研究使用了Joanna Brigg研究所的研究应用于实践模型,该模型通过参考之前的基线临床审计使实验过程得到了改善。选用疼痛、尿失禁和跌倒预防的过程和结果标准作为实验变量,并从临床历史和记录中进行为期12个月的基线和关键点的数据收集。项目资金由西班牙战略卫生行动营于2014年11月进行赞助。 讨论: 本项目的结果将为研究应用于实... | zh-cn |
pair_30816570 | To examine the experiences of health transitions for young people with intellectual disabilities and their carers and identify the implications for nursing practice. A systematic review and critical appraisal of qualitative, quantitative, and mixed methods studies. A search of the relevant literature published 2007-201... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 在于检查智障青少年及其护理人员的健康转变经历,并确定护理实践的含义。 设计: 对定性、定量和混合方法性研究的系统综述和严格评价。 资料来源: 在AMED、ASSIA、CINAHL、MEDLINE、PsycINFO、PubMed和Science Direct Sociological Abstract数据库中搜索了2007至2017年间发表的相关文献。 综述方法: 在搜索中确定的637篇论文中,共有12篇符合本次综述的入选标准。对论文的叙述性综述是通过综合 主要调查结果并将其分为各种理念和新兴主题进行的。 结果: 确定了四大主题:(a)成为成年人;(b)支离破碎的转变过程和护理;(c)父母是情绪混乱的倡导者;以及(d)实现转变... | zh-cn |
pair_30816571 | To explore nursing students' perception of peer learning during cross-cultural learning activities through student-led webinars. An exploratory qualitative study. Thematic analysis of data collected from reflective journals and focus-group interviews of participating nursing students across three international universi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 在跨文化学习活动中,通过学生主导的在线研讨会探究护理专业学生对同伴学习的看法。 设计: 采用考察性定性研究。 方法: 本研究于2017年秋季通过反馈性日志以及焦点团体访谈收集数据,其中由澳大利亚、香港和瑞典三个国际大学护理专业学生参与焦点团体访谈。 结果: 有三个主题:同伴学习建立友谊;同伴学习交流超过了原先的预想;同伴学习是能力的学习。 结论: 同伴学习作为一种教育方法,同跨文化以及学生主导的在线研讨会相结合,为教育提供了新的研究视角。基于完善的教育模式,跨越国界进行在线学习,为国际化创造了新的机遇,不再受个人和机构资金资源的限制。. | zh-cn |
pair_30818908 | The World Health Organization(WHO)has set the goal to eliminate viral hepatitis as a public health threat by 2030, and the key to achieve this ambitious goal lies on the standardized and precise management of pregnant women and their infants by effectively blocking mother-to-child transmission (MTCT) of hepatitis B vir... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 世界卫生组织提出到2030年要实现消除病毒性肝炎对公共卫生威胁的目标，而实现这一宏伟目标的关键在于通过对孕产妇及其新生儿的规范化、精细化管理以有效阻断乙型肝炎母婴传播。规范化管理包括妊娠期筛查、抗病毒干预、婴儿免疫接种、免疫效果的评价以及母乳喂养、分娩方式的选择等重要环节。临床随机对照研究和真实世界临床实践数据结果均已证实，以新生儿联合免疫为基础的综合预防策略能够完全阻断乙型肝炎的母婴传播。制定符合国内外公共卫生需求的新策略，提高公众的疾病认知度，推动规范化管理流程的实施和运用，是当前我国消除病毒性肝炎危害工作的重点环节之一。. | zh-cn |
pair_30818909 | The main transmission route of chronic hepatitis B virus infection is mother-to-child transmission of hepatitis B virus and the main cause of combined immune prophylaxis failure in neonates at the end of pregnancy is high viral load. Moreover, oral administration of nucleos(t)ide analogues (NAs) during the second and t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 乙型肝炎病毒（HBV）母婴传播是慢性HBV感染的主要传播途径，妊娠末期孕妇高病毒载量是导致新生儿联合免疫阻断失败的主要原因。而孕中晚期口服核苷（酸）类似物降低病毒载量，可以显著降低甚至完全阻断HBV母婴传播。现重点讨论高病毒载量HBV携带孕妇孕期口服核苷（酸）类似物抗病毒的必要性和可行性，开始用药时间及病毒载量阈值等问题。. | zh-cn |
pair_30818910 | The reports of liver dysfunction during pregnancy or postpartum have gradually increased in pregnant women who are chronic carriers of hepatitis B virus (HBV), but there is no consensus on when to intervene and how to deal with it. This article reviewed recent literature reports and found that pregnant women who are ch... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着临床上对慢性乙型肝炎病毒携带孕妇母婴阻断的重视，该类人群在妊娠期或产后出现肝功能异常的报道逐渐增多，但何时干预、处理方法等问题尚未形成共识。现回顾近期文献报道，发现慢性乙型肝炎病毒携带孕妇，无论是否采用核苷(酸)类似物(NAs)干预，于妊娠期及产后均有一定比例的肝炎发作、甚至重症化，提示产后并非均能安全停药，需要密切随访。建议根据妊娠周数及丙氨酸氨基转移酶水平分类处理。在妊娠期肝炎发作，采用NAs为主的治疗，产后肝炎发作者可采用NAs或干扰素治疗。有报道采用NAs和干扰素联合治疗可达到更高的治疗目标。. | zh-cn |
pair_30818911 | Hepatitis B virus (HBV) carrier woman of childbearing age with high viral load is an important source of vertical transmission of hepatitis b virus from mother-to-child in China. Routine blockade with immunoglobulin combined with hepatitis B vaccine is used for neonates born to pregnant women with high viral load of he... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 高病毒载量慢性乙型肝炎病毒（HBV）携带的育龄期女性是我国HBV母婴垂直传播的重要传染源。针对HBV高病毒载量孕妇所生新生儿采用免疫球蛋白联合乙型肝炎疫苗进行常规阻断，仍有部分HBV母婴传播阻断失败；在妊娠期应用抗HBV药物，主要是为了降低孕妇血清病毒载量，提高母婴传播阻断率。如果产妇年龄小于30岁、无明显肝纤维化或肝硬化且治疗过程中也无丙氨酸氨基转移酶水平增高> 2倍正常值上限者，产后即可停用抗病毒药物治疗，并于停药后4、12、24周检查丙氨酸氨基转移酶水平，监测肝炎发作情况。如出现肝炎发作，达到治疗标准，可予以抗病毒治疗。. | zh-cn |
pair_30818912 | In 2016, the World Health Assembly endorsed the Global Health Sector Strategy on viral hepatitis, with aim to eliminate viral hepatitis as a public health threat by 2030, which may reduce the number of new cases of chronic hepatitis B by 90% (0.1% HBsAg prevalence among children) and mortality rate by 65%. In order to ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2016年世界卫生大会通过了全球卫生部门病毒性肝炎战略，到2030年消除病毒性肝炎的公共卫生威胁，使慢性乙型肝炎新发病例减少90%（儿童中HBsAg流行率为0.1%），相关死亡病例减少65%。为达成该目标，阻断乙型肝炎病毒（HBV）母婴传播是重中之重，尤其在HBV高流行率的不发达地区尤其重要。现从我国育龄期女性慢性HBV感染状况及其血清学和病毒学特点，以及HBsAg阳性母亲所生新生儿主被动联合免疫中免疫球蛋白最佳剂量、免疫后血清学检测、是否可以增加疫苗剂量、是否需要加强免疫等方面，就进一步完善预防乙型肝炎病毒母婴传播免疫策略进行探讨。. | zh-cn |
pair_30818913 | The China Foundation of Hepatitis Prevention and Control (CFHPC) initiated a project named, 'getting to zero mother-to-child transmission of Hepatitis B,' in July 2015, which aims to further reduce the incidence of mother-to-child transmission through standardized follow-up management of pregnant women and their infant... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2015年7月，中国肝炎防治基金会启动了'乙肝母婴零传播工程'项目，旨在借助移动医疗工具，通过对慢性乙型肝炎病毒感染孕妇及其婴儿的规范化随访管理，进一步降低母婴传播的发生率。3年来，项目建立了覆盖全国的乙型肝炎母婴阻断协作网，共123家医院成为项目成员；制订了技术指导性文件《乙型肝炎母婴阻断临床管理流程》；设计开发了用于随访管理的移动医疗工具-SHIELD APP；组织了以消除病毒性肝炎为主题的国际会议。通过上述举措，提高了公众对乙型肝炎的知晓率，形成了良好的社会氛围，为促进我国病毒性肝炎的防治工作起到了积极的推动作用。. | zh-cn |
pair_30818923 | Hepatic fibrosis is a wound healing and scar repair reaction after liver injury, and is a common pathway for various chronic liver diseases. Activation and proliferation of hepatic stellate cells are the key links in the occurrence and development of hepatic fibrosis. Recent studies have shown that long non-coding RNAs... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝纤维化是肝脏损伤后的创伤愈合和疤痕修复反应，是各种慢性肝病的共同通路。肝星状细胞活化、增殖等是肝纤维化发生、发展的关键环节。近年研究结果显示，长链非编码RNA参与调控肝星状细胞活化、增殖和凋亡，探讨其在肝纤维化的作用机制，将为肝纤维化的诊断、治疗和预后提供新的策略。. | zh-cn |
pair_30818924 | Hepatocellular carcinoma (HCC) is the most common malignant tumors of liver. Rational treatment in early stage of HCC can significantly increase the survival rate of patients. Detection of early-stage liver lesions through diffusion-weighted imaging, diffusion kurtosis imaging, incoherent motion within voxels, magnetic... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝细胞肝癌(HCC)是肝脏最常见的恶性肿瘤。早期HCC合理治疗可明显提高患者的生存率。弥散加权成像，扩散峰度成像，体素内不相干运动，磁共振波谱成像，动态对比增强成像等功能成像通过多个参数对病变的早期检出，性质判断，恶性程度分级及对不同治疗方案疗效能够准确地评估。超快速并行采集技术（CAIPIRINHA）、水脂分离压脂技术（Dixon）及时间分辨交叉随机轨迹成像（TWIST）3种技术的容积插入法屏气扫描检查（VIBE），即CDT-VIBE序列在短时间内可获得多组动脉期图像，发现其他检查无法发现的一过性强化小病灶，并显示病灶起始强化差异，对提示病灶血供特点有重要意义。此外，磁共振成像可预测HCC的微血管侵犯，即间接预测HCC术后或肝移植... | zh-cn |
pair_30818925 | Circular RNA is a class of non-coding RNAs, which are covalently closed and circular at both ends, showing dissimilar characteristics from linear RNA. Several studies have shown that circular RNAs play an important role in the occurrence and development of primary hepatic cancer. By combining with the latest research p... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 环状RNA是一类非编码RNA，其首尾两端共价闭合呈环状，表现出与线性RNA不同的特点。大量研究结果显示，环状RNA在原发性肝癌的发生、发展中发挥了重要的作用。现结合国内外在该领域的最新研究进展，概述环状RNA在肝癌中的异常表达情况及其调控肝癌发生、发展中的机制，分析其作为肝癌分子标志物的重要依据，分析环状RNA在肝癌诊治中的潜在价值。. | zh-cn |
pair_30820978 | Human activities threaten the biodiversity of aquatic mammals across the globe. Conservation of these species hinges on the ability to delineate movements and foraging behaviors of animals, but gaining such insights is hampered by difficulties in tracing individuals over their lives. We determined isotope ratios in tee... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 人类活动威胁着全球水生哺乳动物的生物多样性。对这些物种的保护依赖于对它们的移动和觅食行为的认识, 但这却受限于追踪其个体的完整生活史这一难题。我们利用牙齿中的同位素比 （<sup>87</sup> Sr/<sup>86</sup> Sr、<sup>13</sup> C/<sup>12</sup> C和<sup>18</sup> O/<sup>16</sup> O）, 研究了美国阿拉斯加伊利亚姆纳湖广泛分布的一种鳍足动物 （港海豹 Phoca vitulina） 的独特淡水种群在一生中的移动及资源利用格局。此前, 关于这个种群潜在的独特迁徙行为及其对不同营养资源的利用情况尚不清楚。我们通过测定牙齿同位素, 发现这些海豹终生都在伊利亚姆... | zh-cn |
pair_30820978 | Human activities threaten the biodiversity of aquatic mammals across the globe. Conservation of these species hinges on the ability to delineate movements and foraging behaviors of animals, but gaining such insights is hampered by difficulties in tracing individuals over their lives. We determined isotope ratios in tee... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Isotopos Dentales y una Población Críptica de Focas Costeras de Agua Dulce Resumen Las actividades humanas amenazan a la diversidad de mamíferos acuáticos en todo el mundo. La conservación de estas especies depende de la habilidad para delinear los movimientos y los comportamientos de búsqueda de alimento de los animal... | es |
pair_30827324 | Non-small cell lung cancer (NSCLC) is a kind of lung cancer, because its high incidence has been concerned. Therefore, it has great significance to reveal the pathogenesis of NSCLC. As a transcriptional regulatory factor, MATF-A plays an important role in the development of multiple tumors, can regulate the migration p... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：MRTF-A通过HOTAIR调控非小细胞肺癌细胞A549的增殖及迁移】 【中文摘要：背景与目的 非小细胞肺癌（non-small cell lung cancer, NSCLC）作为肺癌的一种，由于其高发病率一直备受关注。准确揭示其发病机制对于NSCLC的诊断以及治疗具有重要的指导意义。MATF-A作为转录调控因子在多种肿瘤的发生发展过程中发挥着重要作用，可以调控多种肿瘤细胞的迁移过程。HOTAIR是近年研究发现的一个长链非编码RNA，在多种肿瘤中异常表达并参与多种肿瘤的增殖及迁移的进程。本研究旨在探究MRTF-A通过HOTAIR调控NSCLC的增殖及迁移进程。方法 构建MRTF-A的过表达质粒及干扰质粒，检测对A549... | zh-cn |
pair_30827326 | Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have demonstrated some dramatic efficacy in advanced non-small-cell lung cancer (NSCLC) patients with activating EGFR mutation. However, progression-free survivals (PFS) among those patients who were treated with first line EGFR TKIs were inconsist... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：表皮生长因子酪氨酸激酶抑制剂一线治疗突变阳性晚期非小细胞肺癌的临床疗效预测
因素分析】 【中文摘要：背景与目的 一线应用表皮生长因子-酪氨酸激酶抑制剂（epidermal growth factor receptor tyrosine kinase inhibitors, EGFR-TKIs）治疗具有EGFR基因突变的晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）疗效显著，但患者的无进展生存时间（progression free survival, PFS）可有较大差异。既往研究表明一些临床因素可能与疗效相关，本研究旨在探讨影响EGFR-TKI疗效的临床预测因素。方法 收集203例... | zh-cn |
pair_30827327 | The purpose of this study is to compare the survival time of non-small cell lung cancer (NSCLC) patients with different organ metastasis. Among all cancers, the morbidity and mortality of lung cancer is the highest worldwide, which may caused by local recurrence and distant metastasis, and the location of metastasis ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：不同转移部位的非小细胞肺癌患者的
生存时间比较】 【中文摘要：背景与目的 肺癌是全球范围内发病率和死亡率最高的恶性肿瘤，导致其高病死率的主要原因是局部复发和远处转移，而转移部位对患者的预后有一定预测作用，本研究旨在比较不同远处转移部位的非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的生存时间。方法 从美国监测、流行病学和最终结果（Surveillance, Epidemiology, and End Result, SEER）数据库中提取出2010年-2014年间确诊的NSCLC患者共117,542例，回顾性分析其远处转移部位与生存时间的关系。结果 在确诊的117,542例NSCL... | zh-cn |
pair_30827328 | Standard treatment for resectable IIIa/N2 non-small-cell lung cancer (NSCLC) is still under debate. Optional treatments include chemotherapy, radiotherapy and surgery, other options include target therapy and immunotherapy. Multidisciplinary treatment has therefore been emphasized by various clinical trials, including ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：可切除IIIa/N2期非小细胞肺癌治疗模式探讨】 【中文摘要：临床可切除IIIa/N2期非小细胞肺癌（non-small cell lung cancer, NSCLC）的治疗模式一直存在争议，化疗、放疗、手术等治疗手段都有可改善其生存的报道，靶向治疗和免疫治疗的研究也有较多新进展，联合治疗的选择更是很多临床试验研究的重点。联合治疗包括化疗联合手术或放疗，以及化疗、放疗和手术三种治疗的联合。对于NSCLC最佳治疗模式目前尚无定论。本文通过对多项II期、III期临床试验及meta分析、个案报道的综述回顾，比较不同治疗方式对临床可切除IIIa/N2期NSCLC的生存影响，结果显示多学科治疗中手术对于延长患者生存是必要的选择，... | zh-cn |
pair_30827329 | Lung cancer is the most commonly diagnosed cancer worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer seriously affect the patients' quality of life and prognosis. The management of MPE includes thoracentesis, pleurodesis, indwelling pleural catheters and drug perfusion in pleural cavity. Vascula... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：贝伐珠单抗治疗非小细胞肺癌所致恶性胸腔积液的研究进展】 【中文摘要：肺癌是全球范围内发病率最高的恶性肿瘤，晚期肺癌所致的恶性胸腔积液（malignant pleural effusion, MPE）严重影响患者的生活质量和预后。MPE的治疗手段包括胸腔穿刺术、胸膜固定术、胸腔埋管引流、胸腔内灌注治疗等。血管内皮生长因子（vascular endothelial growth factor, VEGF）及其受体是一组影响血管生成的重要配体和受体，是控制血管生成的主要因素，在MPE的形成中发挥重要作用。贝伐珠单抗是一种重组的人源化VEGF单克隆抗体，可与内源性VEGF竞争性结合VEGF受体，抑制新血管生成以及降低血管通透性，... | zh-cn |
pair_30828878 | Different sets of criteria are available in veterinary dermatology for the diagnosis of canine atopic dermatitis (cAD); there are limited data to assess their reliability. The aim of this study was to assess the discriminative and predictive ability of four sets in diagnosing cAD in a population of dogs with different ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 兽医皮肤病学对犬异位性皮炎(cAD)的诊断标准有多种;评估其可靠性的资料有限。 假设/目标: 本研究目的是评估四套诊断标准从不同皮肤病犬群中鉴别和预测出cAD的能力。 动物: 250只在兽医教学医院皮肤科接受检查的犬。 方法和材料: 诊断患有cAD、跳蚤感染(FI)、跳蚤叮咬过敏症(FBH)、疥螨(SM)和其他皮肤病(OD)的犬。 将FI、FBH和SM合并于cAD(MD)相似皮肤病组,所有非异位性犬被归为“总群体”(GP)。四套标准应用于所有犬。对于每套标准,计算其敏感性、特异性、阳性和阴性预测值(PPV,NPV)、似然比(LR)和诊断优势比(DOR)。 结果: 当应用于GP时,敏感性范围为54%-83%,异位性为68%-7... | zh-cn |
pair_30828878 | Different sets of criteria are available in veterinary dermatology for the diagnosis of canine atopic dermatitis (cAD); there are limited data to assess their reliability. The aim of this study was to assess the discriminative and predictive ability of four sets in diagnosing cAD in a population of dogs with different ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Différentes séries de critères sont disponibles en médecine vétérinaire pour le diagnostic de la dermatite atopique canine (cAD) ; il existe un nombre limité de données pour déterminer leur validité. HYPOTHÈSES/OBJECTIFS: Le but de cette étude est de déterminer la capacité discriminative et prédictive de quatre séries ... | fr |
pair_30828878 | Different sets of criteria are available in veterinary dermatology for the diagnosis of canine atopic dermatitis (cAD); there are limited data to assess their reliability. The aim of this study was to assess the discriminative and predictive ability of four sets in diagnosing cAD in a population of dogs with different ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Es sind verschiedene Zusammensetzungen an Kriterien in der Veterinärdermatologie zur Diagnose einer caninen atopischen Dermatitis (cAD) verfügbar; allerdings gibt es nur limitierte Daten über ihre Zuverlässigkeit. Das Ziel dieser Studie war es, die Unterscheidungs- und die Prognosefähigkeit von vier Sets an Kriterien b... | de |
pair_30828878 | Different sets of criteria are available in veterinary dermatology for the diagnosis of canine atopic dermatitis (cAD); there are limited data to assess their reliability. The aim of this study was to assess the discriminative and predictive ability of four sets in diagnosing cAD in a population of dogs with different ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Diferentes conjuntos de critérios estão disponíveis na dermatologia veterinária para o diagnóstico da dermatite atópica canina (DAC). Entretanto, são limitados os dados avaliando a sua confiabilidade. HIPÓTESE/OBJETIVOS: O objetivo deste estudo foi avaliar as habilidades discriminativas e preditivas de quatro conjuntos... | pt |
pair_30828878 | Different sets of criteria are available in veterinary dermatology for the diagnosis of canine atopic dermatitis (cAD); there are limited data to assess their reliability. The aim of this study was to assess the discriminative and predictive ability of four sets in diagnosing cAD in a population of dogs with different ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | diferentes conjuntos de criterios están disponibles en dermatología veterinaria para el diagnóstico de la dermatitis atópica canina (cAD); existe información limitada para evaluar su fiabilidad. HIPÓTESIS/OBJETIVOS: el objetivo de este estudio fue evaluar la capacidad discriminativa y predictiva de cuatro series de cri... | es |
pair_30828896 | Otitis externa is a common multifactorial disease in dogs. The diversity of the cutaneous microbiota in dogs appears to decrease in diseased states. However, little is known about the microbiota of the canine ear and how it is altered by disease. To describe the otic bacterial microbiota in dogs with otitis externa com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 犬外耳炎是常见的多因素疾病。犬皮肤微生物群的多样性似乎在患病状态下降低。然而,人们对犬耳道微生物群及其如何被疾病改变知之甚少。 假设/目标: 描述与健康犬相比,外耳炎患犬的耳道细菌菌群。 动物: 从18只临床和细胞学都证明患有外耳炎的犬,以及8只临床和细胞学证明无外耳炎正常犬的耳道采集样品。 方法和材料: 分离每个样品的DNA,进行16S rRNA基因V4高变区的扩增,并送Illumina®公司测序。使用生物信息学软件MOTHUR处理序列。 结果: 共鉴定出27种不同门的细菌。与健康耳道相比,患病耳道的α多样性明显降低。两组之间的细菌种群结构和种类也不同。线性判别分析的效应量分析确定了丰度差异的153个可操作分类单位(OTU... | zh-cn |
pair_30828896 | Otitis externa is a common multifactorial disease in dogs. The diversity of the cutaneous microbiota in dogs appears to decrease in diseased states. However, little is known about the microbiota of the canine ear and how it is altered by disease. To describe the otic bacterial microbiota in dogs with otitis externa com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L'otite externe est une maladie multifactorielle fréquente chez le chien. La diversité du microbiote cutané chez le chien semble diminuer dans les états pathologiques. Cependant, on sait peu de chose sur le microbiote de l'oreille canine et comment il est altéré en fonction des maladies. HYPOTHÈSES/OBJECTIFS: Décrire l... | fr |
pair_30828896 | Otitis externa is a common multifactorial disease in dogs. The diversity of the cutaneous microbiota in dogs appears to decrease in diseased states. However, little is known about the microbiota of the canine ear and how it is altered by disease. To describe the otic bacterial microbiota in dogs with otitis externa com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Otitis externa ist eine häufige multifaktorielle Erkrankung von Hunden. Die Diversität der kutanen Mikrobioma bei Hunden scheint in Krankheitszuständen abzunehmen. Es ist jedoch wenig bekannt über das Mikrobiom des Hundeohres und wie es sich im Krankheitszustand verändert. Eine Beschreibung der otischen bakterielle... | de |
pair_30828896 | Otitis externa is a common multifactorial disease in dogs. The diversity of the cutaneous microbiota in dogs appears to decrease in diseased states. However, little is known about the microbiota of the canine ear and how it is altered by disease. To describe the otic bacterial microbiota in dogs with otitis externa com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A otite externa é uma doença multifatorial comum em cães. A diversidade da microbiota cutânea parece sofrer redução durante estados patológicos. Entretanto, pouco se sabe sobre a microbiota da orelha canina e as suas alterações causadas por enfermidades. HIPÓTESE/OBJETIVOS: Descrever a microbiota bacteriana ótica em cã... | pt |
pair_30828896 | Otitis externa is a common multifactorial disease in dogs. The diversity of the cutaneous microbiota in dogs appears to decrease in diseased states. However, little is known about the microbiota of the canine ear and how it is altered by disease. To describe the otic bacterial microbiota in dogs with otitis externa com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la otitis externa es una enfermedad multifactorial común en los perros. La diversidad de la microbiota cutánea en perros parece disminuir en estados de enfermedad. Sin embargo, poco se sabe sobre la microbiota del oído canino y cómo se altera por enfermedad. HIPÓTESIS/OBJETIVOS: describir la microbiota bacteriana ótica... | es |
pair_30828906 | Blepharitis is a common finding in many dogs with various skin diseases. To establish a definition for canine blepharitis versus periocular dermatitis (POD), to evaluate the clinical findings and underlying skin diseases of blepharitis, and to document the effects of blepharitis on tear production in dogs. One hundred ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 睑缘炎在许多患有各种皮肤病的犬身上常见。 目的: 建立犬睑缘炎与眼周皮炎(POD)的定义,评估睑缘炎的临床发现和潜在皮肤病,并记录睑缘炎对犬眼泪量的影响。 动物: 一百二十只有睑缘炎临床症状和明确皮肤病诊断的私家犬,。 方法和材料: 对患有睑缘炎,与同时患有睑缘炎和POD犬的临床症状和潜在疾病进行前瞻性评估。 结果: 短头犬比其他品种更容易出现睑缘炎。仅有25只犬患有睑缘炎[三只犬(2.9%)没有,22只犬(21.5%)有眼周皮肤以外的皮肤病变]。 102例中有71例(69%)除睑缘炎外还有POD。有6例无法区别睑缘炎和POD。典型病变包括脱毛/ 少毛(97%)、红斑(93%)、眼睑水肿(50%)和结痂(39.2%)。过敏性... | zh-cn |
pair_30828906 | Blepharitis is a common finding in many dogs with various skin diseases. To establish a definition for canine blepharitis versus periocular dermatitis (POD), to evaluate the clinical findings and underlying skin diseases of blepharitis, and to document the effects of blepharitis on tear production in dogs. One hundred ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La blépharite est fréquente chez de nombreux chiens présentant des dermatoses. Déterminer une définition de la blépharite canine versus la dermatite périoculaire (POD), évaluer les données clinique et les dermatoses sous jacentes des blépharites et de documenter les effets de la blépharite sur la production de larmes c... | fr |
pair_30828906 | Blepharitis is a common finding in many dogs with various skin diseases. To establish a definition for canine blepharitis versus periocular dermatitis (POD), to evaluate the clinical findings and underlying skin diseases of blepharitis, and to document the effects of blepharitis on tear production in dogs. One hundred ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Eine Blepharitis tritt häufig bei vielen Hunden mit verschiedenen Hauterkrankungen auf. Eine Definition für die Blepharitis des Hundes zu erstellen im Kontrast zu einer periokulären Dermatitis (POD), eine Evaluierung der klinischen Befunde und der zugrundeliegenden Hauterkrankungen einer Blepahritis, und eine Dokumenta... | de |
pair_30828906 | Blepharitis is a common finding in many dogs with various skin diseases. To establish a definition for canine blepharitis versus periocular dermatitis (POD), to evaluate the clinical findings and underlying skin diseases of blepharitis, and to document the effects of blepharitis on tear production in dogs. One hundred ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Blefarite é um achado comum em muitos cães com diversas doenças de pele. Estabelecer uma definição para blefarite canina versus dermatite periocular (POD), avaliar os achados clínicos e as doenças de pele primárias de blefarite, e documentar os efeitos da blefarite na produção de lágrima. Cento e dois cães de proprietá... | pt |
pair_30828906 | Blepharitis is a common finding in many dogs with various skin diseases. To establish a definition for canine blepharitis versus periocular dermatitis (POD), to evaluate the clinical findings and underlying skin diseases of blepharitis, and to document the effects of blepharitis on tear production in dogs. One hundred ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la blefaritis es un hallazgo común en muchos perros con diversas enfermedades de la piel. OBJETIVOS: establecer una definición de blefaritis canina frente a dermatitis periocular (POD), evaluar los hallazgos clínicos y las enfermedades subyacentes de la blefaritis y documentar los efectos de la blefaritis en la producc... | es |
pair_30828914 | The long-term effects of allergen specific immunotherapy (ASIT) on concentrations of circulating immunoglobulin E (IgE) and immunoglobulin G (IgG) in horses have not been reported. To document changes in clinical severity of horses with atopic dermatitis (AD) and to monitor allergen-specific IgE and IgG concentrations ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 过敏原特异性免疫治疗(ASIT)对马循环免疫球蛋白E(IgE)和免疫球蛋白G(IgG)浓度的长期影响尚未见报道。 目的: 记录马异位性皮炎(AD)临床严重程度的变化,并监测两年ASIT过程中过敏原特异性IgE和IgG浓度。 动物: 19匹条件性诊断为AD的私家马。 方法和材料: 根据区域过敏原的皮内试验(IDT)(n = 7); 酶联免疫吸附试验(ELISA)检测特异性IgE(n = 6); 或综合两种试验(n = 6)结果,随机分为三个ASIT组。在零时和每隔四个月测量ASIT中包含的过敏原特异性IgE和IgG的血清浓度。采用视觉模拟评分(VAS)记录0、12和24个月时临床症状的严重程度。 结果: IgE与速发及迟发ID... | zh-cn |
pair_30828914 | The long-term effects of allergen specific immunotherapy (ASIT) on concentrations of circulating immunoglobulin E (IgE) and immunoglobulin G (IgG) in horses have not been reported. To document changes in clinical severity of horses with atopic dermatitis (AD) and to monitor allergen-specific IgE and IgG concentrations ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les effets au long cours de l'immunothérapie spécifique d'allergène (ASIT) sur les concentrations d'immunoglobulines E (IgE) et immunoglobulines G (IgG) circulantes chez le cheval n'ont pas été décrits. Documenter les changements de sévérité clinique des chevaux avec dermatite atopique (AD) et monitorer les concentrati... | fr |
pair_30828914 | The long-term effects of allergen specific immunotherapy (ASIT) on concentrations of circulating immunoglobulin E (IgE) and immunoglobulin G (IgG) in horses have not been reported. To document changes in clinical severity of horses with atopic dermatitis (AD) and to monitor allergen-specific IgE and IgG concentrations ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Langzeitauswirkungen einer Allergen-spezifischen Immuntherapie (ASIT) auf die Konzentrationen der zirkulierenden Immunglobulin E (IgE) und Immunglobulin G (IgG) bei Pferden ist bisher noch nicht beschrieben worden. Eine Dokumentation der Veränderungen im klinischen Ausmaß der Veränderungen bei Pferden mit atopische... | de |
pair_30828914 | The long-term effects of allergen specific immunotherapy (ASIT) on concentrations of circulating immunoglobulin E (IgE) and immunoglobulin G (IgG) in horses have not been reported. To document changes in clinical severity of horses with atopic dermatitis (AD) and to monitor allergen-specific IgE and IgG concentrations ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Os efeitos a longo prazo da imunoterapia alérgeno-específica (ASIT) nas concentrações séricas de imunoglobulina E (IgE) e imunoglobulina G (IgG) em equinos não foram ainda relatados. Documentar as alterações na gravidade dos sinais clínicos da dermatite atópica (DA) em equinos e monitorar as concentrações de IgE e IgG ... | pt |
pair_30828914 | The long-term effects of allergen specific immunotherapy (ASIT) on concentrations of circulating immunoglobulin E (IgE) and immunoglobulin G (IgG) in horses have not been reported. To document changes in clinical severity of horses with atopic dermatitis (AD) and to monitor allergen-specific IgE and IgG concentrations ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | no se han encontrado publicaciones acerca de los efectos a largo plazo de la inmunoterapia específica con alérgenos (ASIT) sobre las concentraciones de inmunoglobulina E (IgE) circulante y la inmunoglobulina G (IgG) en caballos. OBJETIVOS: documentar los cambios en la severidad de manifestaciones clínicas de caballos c... | es |
pair_30828915 | Donkeys are important throughout the world as work animals and occasionally as pets or a meat source. Most descriptions of skin disease in donkeys are reported in small case series, textbooks or review articles. To document skin diseases and their prevalence in donkeys and to investigate predilections for the most comm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 驴在世界各地都是重要的实验动物,偶尔也作为宠物或肉类来源。驴皮肤病的报告多见于个案系列、教科书或综述文章。 假设/目标: 记录驴皮肤病及其流行情况,并调查最常见的易感疾病。 动物: 四所兽医学校治疗的156头驴病例。 方法和材料: 使用关键词”驴”搜索计算机,对在加州大学戴维斯分校(UCD)兽医学院的病历进行回顾性研究。同时对来自法国南特兽医学院、荷兰乌得勒支和比利时根特记录的驴也以类似方式进行了搜查,搜索中包含的时间段因机构而异。 结果: 在UCD的记录中,346头(24%)驴中有83头患有皮肤病,最常见的诊断是昆虫叮咬、过敏、肉样瘤和丽线虫病;在南特的记录中,144头中有36头(25%)患有皮肤病,最常见的诊断是肉样瘤和... | zh-cn |
pair_30828915 | Donkeys are important throughout the world as work animals and occasionally as pets or a meat source. Most descriptions of skin disease in donkeys are reported in small case series, textbooks or review articles. To document skin diseases and their prevalence in donkeys and to investigate predilections for the most comm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les singes sont nombreux à travers le monde en tant qu'animal de travail et occasionnellement comme animal de compagnie ou comme source de nourriture. La plupart des descriptions des dermatoses du singe est rapportée dans de petites séries de cas, livres ou articles de revue. HYPOTHÈSES/OBJECTIFS: Documenter les dermat... | fr |
pair_30828915 | Donkeys are important throughout the world as work animals and occasionally as pets or a meat source. Most descriptions of skin disease in donkeys are reported in small case series, textbooks or review articles. To document skin diseases and their prevalence in donkeys and to investigate predilections for the most comm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Esel sind auf der ganzen Welt wichtig als Arbeitstiere und gelegentlich als Haustiere oder als Fleischquelle. Die meisten Beschreibungen von Hauterkrankungen bei Eseln erschienen in kleinen Fallserien, in Textbüchern oder in Review Artikeln. Das Ziel dieser Studie war es die Hauterkrankungen und ihre Prävalenzen bei Es... | de |
pair_30828915 | Donkeys are important throughout the world as work animals and occasionally as pets or a meat source. Most descriptions of skin disease in donkeys are reported in small case series, textbooks or review articles. To document skin diseases and their prevalence in donkeys and to investigate predilections for the most comm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Os jumentos são importantes ao redor do mundo como animais de trabalho e ocasionalmente como pets ou fonte de carne. A maioria das descrições de dermatopatias em jumentos são feitas em pequenas séries de casos, livros ou artigos de revisão. HIPÓTESE/OBJETIVOS: Documentar as dermatopatias e sua prevalência em jumentos e... | pt |
pair_30828915 | Donkeys are important throughout the world as work animals and occasionally as pets or a meat source. Most descriptions of skin disease in donkeys are reported in small case series, textbooks or review articles. To document skin diseases and their prevalence in donkeys and to investigate predilections for the most comm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | los burros son importantes en todo el mundo como animales de trabajo y, en ocasiones, como animales de compañía o como fuente de carne. La mayoría de las descripciones de enfermedades de la piel en burros se describen en series de casos pequeños, libros de texto o artículos de revisión. HIPÓTESIS/OBJETIVOS: documentar ... | es |
pair_30830697 | An increasing number of culturally adapted family-level interventions address mental health disparities with marginalized populations in the United States. However, with these developments many barriers have arisen, such as challenges with degree of cultural fit, engagement, and sustainability. We conducted 12 elite ph... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 针对特定文化族群的家庭层面干预来解决处于美国社会边缘的人群心理健康差距问题的做法越来越多,但是在其发展过程中也会遇到一些障碍,比如文化适应程度方面的困难,如何让病人配合和治疗措施持续性的问题等等。我们对12名顶级的心理健康学者进行了现象学的访谈,这些学者均参与过针对很多在美国境内和境外的拉丁美洲社群家庭进行预防和干预的家庭研究。他们都谈到了他们在研究过程中克服障碍的经历。我们使用主题分析法来解码和分析参与者的访谈内容,我们的结果显示在以前的文献中此类研究选题确实存在空白,并指出了克服这些文化调适研究中的障碍的可能路径。主题包括有必要:(a)更好地理解文化和具体生活环境共同的相互作用;(b)以社群为中心的方法来讨论实施过程中的困难;(... | zh-cn |
pair_30830697 | An increasing number of culturally adapted family-level interventions address mental health disparities with marginalized populations in the United States. However, with these developments many barriers have arisen, such as challenges with degree of cultural fit, engagement, and sustainability. We conducted 12 elite ph... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Un número cada vez mayor de intervenciones adaptadas culturalmente a nivel familiar abordan las desigualdades en la salud mental con poblaciones marginadas en los Estados Unidos. Sin embargo, con estos avances han surgido muchos obstáculos, como las dificultades con el grado de integración cultural, la participación y ... | es |
pair_33783150 | Industrial microorganisms and their products are widely used in various fields such as industry, agriculture, and medicine, which play a pivotal role in economy. Efficient industrial strains are the key to improve production efficiency, and advanced fermentation technology as well as instrument platform is also importa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 工业微生物及其产品广泛用于工业、农业、医药等诸多领域，相关产业在国民经济中具有举足轻重的地位。高效的菌株是提高生产效率的核心，而先进发酵技术和仪器平台对充分开发菌株代谢潜能也很重要。近年来，工业微生物领域的研究取得了快速进展，人工智能、高效基因组编辑技术和合成生物学技术逐渐广泛使用，相关产业应用也在不断扩展。为进一步促进工业微生物在生物制造等领域的应用，《生物工程学报》特 组织出版专刊，从微生物菌株的多样性和生理代谢、菌株改造技术、发酵过程优化和放大，高通量微液滴培养装备开发以及工业微生物应用等方面，分别阐述目前的研究进展，并展望未来的发展趋势，为促进工业微生物及生物制造等产业的发展奠定基础。. | zh-cn |
pair_33783151 | Yeast are comprised of diverse single-cell fungal species including budding yeast Saccharomyces cerevisiae and various nonconventional yeasts. Budding yeast is well known as an important industrial microorganism, which has been widely applied in various fields, such as biopharmaceutical and health industry, food, light... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 酵母是一类包括酿酒酵母和非常规酵母在内的多种单细胞真菌的总称，其中酿酒酵母是应用较多的重要工业微生物，广泛应用于生物医药、食品、轻工和生物燃料生产等不同生物制造领域。近年来，研究者从不同生态环境中分离了大量的酵母菌株，鉴定了多个新种，也发现了抗逆性不同以及具有多种活性产物合成能力的菌株，证明天然酵母资源具有丰富的生物多样性和功能多样性。利用基因组挖掘以及转录组、蛋白组等多组学分析研究，可进一步开发利用酵母遗传多样性，获得酶和调节蛋白的基因以及启动子等遗传元件改造酵母菌株。除了利用酵母的天然遗传多样性，还可通过诱变、驯化、代谢工程改造及合成生物学等技术产生具有多种非天然多样性的菌株。此外，对天然遗传元件也可以进行突变和定向进化，所产生... | zh-cn |
pair_33783152 | Due to abundant availability of shale gas and biogas, methane has been considered as one of the most potential carbon sources for industrial biotechnology. Methanotrophs carrying the native methane monooxygenase are capable of using methane as a sole energy and carbon source, which provides a novel strategy for reducin... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 作为来源广泛、储量丰富的有机碳一气体，甲烷被认为是下一代工业生物技术中最具潜力的碳原料之一。嗜甲烷菌能够利用其体内的甲烷单加氧化酶，将甲烷作为唯一的碳源和能源进行生长和代谢，这为温室气体减排及其开发利用提供了新的策略。目前，嗜甲烷菌生物催化体系的相关研究已开展多年，随着系统生物学和合成生物学的快速发展，利用代谢工程合理改造嗜甲烷菌代谢途径以提高甲烷转化效率，已经实现了生物转化甲烷制备多种大宗化学品和生物燃料。本文详细讨论并介绍了嗜甲烷菌催化氧化甲烷的相关代谢途径、高效细胞工厂构建及部分化学品生物合成的最新研究进展，并对甲烷生物转化未来的发展方向和面临的技术挑战进行了讨论和展望。. | zh-cn |
pair_33783153 | As a model industrial host and microorganism with the generally regarded as safe (GRAS) status, Corynebacterium glutamicum not only produces amino acids on a large scale in the fermentation industry, but also has the potential to produce various new products. C. glutamicum usually encounters various stresses in the pro... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 谷氨酸棒杆菌Corynebacterium glutamicum作为一般被认为具有生物安全性的一种模式工业微生物，不仅在发酵工业中成功用于大规模生产氨基酸，而且具有合成多种新型化学品的潜力。谷氨酸棒杆菌菌株在生产化合物时，经常会受到各种逆境条件的胁迫，从而降低细胞活力和生产性能。合成生物学的发展为提高谷氨酸棒杆菌的鲁棒性提供了新的技术手段。本文总结了谷氨酸棒杆菌应对发酵过程中各种胁迫的耐受机制。同时，重点介绍提高谷氨酸棒杆菌底盘细胞鲁棒性和耐受性的合成生物学新策略，包括挖掘新的抗逆元件、改造转录调控因子、利用适应性进化策略挖掘抗逆功能模块等。最后，从生物传感器、转录调控因子的筛选和设计、多种调控元件利用等方面对提高谷氨酸棒杆菌底盘细... | zh-cn |
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