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class | id int32 225 5.32k | answers dict |
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1,689 | Chikungunya: A Potentially Emerging Epidemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860491/
SHA: f7c3160bef4169d29e2a8bdd79dd6e9056d4774c
Authors: Thiboutot, Michelle M.; Kannan, Senthil; Kawalekar, Omkar U.; Shedlock, Devon J.; Khan, Amir S.; Sarangan, Gopalsamy; Srikanth, Padma; Weiner, David B.; Muthumani... | How many days is the incubation period? | false | 2,495 | {
"text": [
"2-6 d"
],
"answer_start": [
5443
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | What is the premise for apathogenic forms to blunt any pathological response in the host? | false | 4,482 | {
"text": [
"would tend to induce an earlier innate response that would render it more likely that the virus would be quickly cleared or rendered less competent in its replication"
],
"answer_start": [
8136
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} |
1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What is the enhanced memory immune response linked to? | false | 1,656 | {
"text": [
"intrinsic augmentation of immunity induced by the vector."
],
"answer_start": [
43357
]
} |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What are the most common methods of inhaled delivery of medications? | false | 1,616 | {
"text": [
"Metered dose inhalers (MDIs) and dry powder inhalers (DPIs)"
],
"answer_start": [
4624
]
} |
1,623 | Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/
SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c
Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent
Date: 2016-09-21... | When does the influenza vaccination campaign in Reunion Island start? | false | 4,093 | {
"text": [
"April"
],
"answer_start": [
2971
]
} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | How have some sero-assays bypassed the risks of working with infectious virus? | false | 4,239 | {
"text": [
"using a recombinant lentivirus expressing MERS-CoV spike protein and luciferase"
],
"answer_start": [
17808
]
} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What happens during viral infection of healthy individuals? | false | 3,954 | {
"text": [
"these factors are not released to any great extent and do not activate an ILC2 response during viral infection in healthy individuals (Yan et al., 2016; Tan et al., 2018a) ; despite augmenting a type 2 exacerbation in chronically inflamed airways (Jurak et al., 2018) . These classical mechanisms of v... |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | What is the the proportion of deaths among those infected with MERS-CoV? | false | 4,273 | {
"text": [
"is much higher than that known for the HCoVs NL63, HKU1, 229E or OC43"
],
"answer_start": [
29785
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} |
1,585 | Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789439/
SHA: efba2008a6ccf1ad2614aebd79a6a741ea6538b9
Authors: Jin, Yi; Zhang, Yuewei; Wan, Chunyan; Wang, Hongjun; H... | Why have antiretrovirals medications had limited benefit in treating influenza? | false | 5,220 | {
"text": [
"drug-resistance and frequent antigenic mutation"
],
"answer_start": [
2472
]
} |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the role of C-C Motif Chemokine Ligand 3 Like 1 (CCL3L1) in mother to child transmission of HIV-1? | false | 316 | {
"text": [
"High copy numbers of CCL3L1, a potent HIV-1 suppressive ligand for CCR5, are associated with higher chemokine production and lower risk of MTCT of HIV-1 among South African infants"
],
"answer_start": [
28143
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} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What does the immune response elicited by these agents lead to? | false | 3,870 | {
"text": [
"infiltration of activated immune cells that further release inflammatory mediators that cause acute symptoms such as increased mucus production, cough, wheeze and shortness of breath."
],
"answer_start": [
3739
]
} |
1,604 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What does a chest x-ray look like for a patient with a severe case of human adenovirus type 55 (HAdV-55)? | false | 3,249 | {
"text": [
"CXRs revealed multiple bilateral lobar or segment consolidation in the lungs of all five patients, and radiographic lesions progressed rapidly after ICU admission"
],
"answer_start": [
9825
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} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | Why is there an increased risk to humans of spill-over during calving season? | false | 4,280 | {
"text": [
"due to new infections among naïve DC populations"
],
"answer_start": [
42006
]
} |
1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | Why is a revision of current vaccines is needed? | false | 1,650 | {
"text": [
"strategies for at-risk populations, particularly those at either end of the age spectrum"
],
"answer_start": [
41899
]
} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | Approximately what percentage of MERS cases were died outside KSA? | false | 4,368 | {
"text": [
"21 %"
],
"answer_start": [
49531
]
} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What sustains the inflammation in the airway? | false | 4,024 | {
"text": [
"state of constant oxidative stress"
],
"answer_start": [
32365
]
} |
1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What was the first reported baculovirus vector based vaccine for influenza? | false | 1,579 | {
"text": [
"using Autographa californica nuclear polyhedrosis virus (AcNPV) expressing the HA of PR8 under control of the CAG promoter (AcCAG-HA)"
],
"answer_start": [
20353
]
} |
1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What is the advantage of AAV vector? | false | 1,561 | {
"text": [
"As members of the parvovirus family, AAVs are small non-enveloped viruses that are stable and amenable to long-term storage without a cold chain."
],
"answer_start": [
14354
]
} |
2,620 | Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak
https://doi.org/10.3390/jcm9020388
SHA: bf20dda99538a594eafc258553634fd9195104cb
Authors: Zhao, Shi; Musa, Salihu S.; Lin, Qianying; Ran, Jinjun; ... | As of 26 January 2020, what had the outbreak resulted in? | false | 1,889 | {
"text": [
"k had resulted in 2066 (618 of them are in Wuhan) confirmed cases and 56 (45 of them were in Wuhan) deaths in"
],
"answer_start": [
2405
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} |
2,526 | Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029449/
SHA: 90de2d957e1960b948b8c38c9877f9eca983f9eb
Authors: Cowling, Benjamin J; Leung, Gabriel M
Date: 2020-02-13
DOI: 10.2807/1560-7917.es.2020... | How does the transmission of the respiratory virus happen? | false | 2,978 | {
"text": [
"through large respiratory droplets,"
],
"answer_start": [
5617
]
} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | Approximately how many deaths have been averted in Western Europe with current non-pharmaceutical interventions remaining in place until the end of March? | false | 808 | {
"text": [
"59,000 deaths"
],
"answer_start": [
3819
]
} |
1,713 | Ebola Virus Maintenance: If Not (Only) Bats, What Else?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213544/
SHA: f16da7cf7a952fb981dfc0d77280aac9c3ab933a
Authors: Caron, Alexandre; Bourgarel, Mathieu; Cappelle, Julien; Liégeois, Florian; De Nys, Hélène M.; Roger, François
Date: 2018-10-09
DOI: 10.3390/v10100549
Li... | What is the structure of the Ebolavirus? | false | 5,315 | {
"text": [
"single-strand RNA filoviruses"
],
"answer_start": [
2270
]
} |
1,689 | Chikungunya: A Potentially Emerging Epidemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860491/
SHA: f7c3160bef4169d29e2a8bdd79dd6e9056d4774c
Authors: Thiboutot, Michelle M.; Kannan, Senthil; Kawalekar, Omkar U.; Shedlock, Devon J.; Khan, Amir S.; Sarangan, Gopalsamy; Srikanth, Padma; Weiner, David B.; Muthumani... | What dose this review describe? | false | 2,487 | {
"text": [
"its clinical features and pathogenesis and its symptoms and complications, and finally nominates a possible vaccine approach against CHIKV infection."
],
"answer_start": [
3049
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | What is HTNV? | false | 4,464 | {
"text": [
"etiologic agent, Hantaan virus"
],
"answer_start": [
4256
]
} |
1,645 | Pre-existing immunity against vaccine vectors – friend or foe?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542731/
SHA: f5bdf18567bb3760e1ce05008135f0270badbd5c
Authors: Saxena, Manvendra; Van, Thi Thu Hao; Baird, Fiona J.; Coloe, Peter J.; Smooker, Peter M.
Date: 2013-01-27
DOI: 10.1099/mic.0.049601-0
License: cc... | What are examples of delivery vectors for commercial anti-Salmonella vaccines? | false | 809 | {
"text": [
"Ty21a for typhoid fever in humans, several Salmonella serovars against salmonellosis in chickens and other animals"
],
"answer_start": [
3507
]
} |
188 | The Battle Against Coronavirus Disease 2019 (COVID-19): Emergency Management
and Infection Control in a Radiology Department
https://www.jacr.org/article/S1546-1440(20)30285-4/pdf
Journal Pre-proof
Zixing Huang, Shuang Zhao, Zhenlin Li, Weixia Chen, Lihong Zhao, Lipeng Deng, Bin
Song
PII: S1546-1440(20)30285-4
DOI: htt... | How many COVID deaths occurred in Chinese mainland as of March 11th? | false | 2,464 | {
"text": [
"3,169"
],
"answer_start": [
4765
]
} |
1,665 | Mucosal Vaccination with Recombinant Lactobacillus casei-Displayed CTA1-Conjugated Consensus Matrix Protein-2 (sM2) Induces Broad Protection against Divergent Influenza Subtypes in BALB/c Mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979752/
SHA: efaa556b484fbcd9cc34832ffac53ef3e834e9c0
Authors: Chowdhury, Moha... | Why have M2-based vaccines been ineffective? | false | 5,186 | {
"text": [
"low immunogenicity"
],
"answer_start": [
3384
]
} |
1,666 | Nanopore sequencing as a revolutionary diagnostic tool for porcine viral enteric disease complexes identifies porcine kobuvirus as an important enteric virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026206/
SHA: eff8bed68ef6109e8f0c51a8b1ec4b6ca5b6329e
Authors: Theuns, Sebastiaan; Vanmechelen, Bert; Bernaert, Q... | Which strain was similar to other Belgian porcine kobuvirus isolates? | false | 5,291 | {
"text": [
"17V079"
],
"answer_start": [
14012
]
} |
1,623 | Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/
SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c
Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent
Date: 2016-09-21... | What does the retrospective study use? | false | 4,033 | {
"text": [
"nasal swabs collected by sentinel GPs from ILI patients in 2011 and 2012."
],
"answer_start": [
666
]
} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | What would aid accurate calculation of a case fatality ratio? | false | 4,379 | {
"text": [
"Global alignment of case definitions"
],
"answer_start": [
67480
]
} |
1,674 | Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523942/
SHA: f00f183d0bce0091a02349ec1eab44a76dad9bc4
Authors: Henry, Kevin A.; Arbabi-Ghahroudi, Mehdi; Scott, Jam... | What is the potential of phage for infectious and chronic diseases? | false | 1,724 | {
"text": [
"prophylactic and therapeutic agent"
],
"answer_start": [
1134
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} |
1,674 | Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523942/
SHA: f00f183d0bce0091a02349ec1eab44a76dad9bc4
Authors: Henry, Kevin A.; Arbabi-Ghahroudi, Mehdi; Scott, Jam... | What killed prostate cancer cells in vitro? | false | 1,758 | {
"text": [
"M13 phage loaded with doxorubicin and displaying a targeting peptide on pIII"
],
"answer_start": [
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} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | What are older DCs are more likely to be positive for? | false | 4,278 | {
"text": [
"seropositive and RNA or virus negative"
],
"answer_start": [
38835
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} |
1,689 | Chikungunya: A Potentially Emerging Epidemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860491/
SHA: f7c3160bef4169d29e2a8bdd79dd6e9056d4774c
Authors: Thiboutot, Michelle M.; Kannan, Senthil; Kawalekar, Omkar U.; Shedlock, Devon J.; Khan, Amir S.; Sarangan, Gopalsamy; Srikanth, Padma; Weiner, David B.; Muthumani... | What are the strengths and advantages of DNA based vaccine? | false | 2,529 | {
"text": [
"its ability to induce cross-reactive immune responses against the three distinct phylogenetic groups of CHIKV. Also DNA-based vaccines can be produced more rapidly than protein-based vaccines."
],
"answer_start": [
20667
]
} |
2,461 | Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418403/
SHA: 5caced13bcb8a42cca41369c5a71ae7df5381ca8
Authors: Wang, Jialu; Huang, Lulu; Mou, Chunxiao; Zhang, En; Wang, Yongheng; ... | What cells are infected by the PED virus? | false | 603 | {
"text": [
"intestine epithelial cells"
],
"answer_start": [
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]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | For what can the Syrian hamster model used? | false | 4,563 | {
"text": [
"ANDV or the related Maporal virus from Venezuela, for which an HCPS-mimetic disease is observed"
],
"answer_start": [
20140
]
} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | Why is it statistically impossible to determine which individual intervention had the greatest effect on reducing the coronavirus reproduction number? | false | 869 | {
"text": [
"close spacing of interventions in time"
],
"answer_start": [
16248
]
} |
2,461 | Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418403/
SHA: 5caced13bcb8a42cca41369c5a71ae7df5381ca8
Authors: Wang, Jialu; Huang, Lulu; Mou, Chunxiao; Zhang, En; Wang, Yongheng; ... | What are the components of the gut-associated lymphoid tissue? | false | 609 | {
"text": [
"Peyer's patches (PPs), isolated lymphoid follicles (ILFs), mesenteric lymph nodes (MLNs), and scatter throughout the subepithelial lamina propria (LP) of the small intestine and colon"
],
"answer_start": [
5040
]
} |
2,668 | 2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081861/
SHA: f323af9a07cc54faf9bdbabadaacb0e8b46f99a2
Authors: Koenig, Kristi L.; Beÿ, Christian K.; McDonald, Eric C.
Date: 2020-01-31
DOI: 10.5811/westjem.2020.1.46760
License: cc-... | Is it possible to get infected with COVID and another virus? | false | 2,198 | {
"text": [
"Although the likelihood of coinfection of 2019-nCoV and another respiratory virus is thought to be low, a positive finding of another respiratory pathogen does not exclude the diagnosis of 2019-nCoV"
],
"answer_start": [
14067
]
} |
2,669 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | What does the author anticipate that continued efforts will lead to? | false | 4,151 | {
"text": [
"Another mRNA under post-transcriptional regulation by Regnase-1 and Roquin"
],
"answer_start": [
5011
]
} |
1,684 | A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804704/
SHA: f6ed1f1e9999e57793addb1c9c54f61c7861a995
Authors: Cheung, Benny KW; Yim, Howard CH; Lee, Norris CM; Lau, Allan SY
Date: 2009-12-17
DOI: 10.1186/1471-2172-10-64
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1,698 | Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
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2,683 | Estimating the number of infections and the impact of non-
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30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | One way to understand the impact of interventions? | false | 873 | {
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1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
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Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | What fraction of MERS cases shed viral RNA in their LRT specimens (tracheal aspirates and sputum) ? | false | 4,262 | {
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1,595 | Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828/
SHA: f02d0c1e8b0109648e578662dc250abe349a033c
Authors: Chen, I-Yin; Moriyama, Miyu; Chang, Ming-Fu; Ichinohe, Takeshi
Date: 2019-01-29
DOI: 10.3389/fmicb.2019.00050
Licens... | What type of ion channels are formed by the SARS-CoV E protein? | false | 294 | {
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1,573 | Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048719/
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Authors: Liu, Wen-Kuan; Liu, Qi... | What are the ages of the patients in this study? | false | 3,272 | {
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1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
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Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | What conditions are considered upper respiratory tracts infections? | false | 328 | {
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1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819164/
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Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | What molecules have been shown to hinder T cell responses to viral infections? | false | 331 | {
"text": [
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1,557 | Changes in pulmonary tuberculosis prevalence: evidence from the 2010 population survey in a populous province of China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890533/
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Authors: Wei, Xiaolin; Zhang, Xiulei; Yin, Jia; Walley, John; Beanland, Rachel; Zou, Guanyang; Zha... | What was the prevalence rate in Shandong in 2010 for sputum positive cases of tuberculosis? | false | 3,028 | {
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1,698 | Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064339/
SHA: f2cc0d63ff2c4aaa127c4caae21d8f3a0067e3d5
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"text": [
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2,463 | SARS to novel coronavirus – old lessons and new lessons
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026896/
SHA: 5d254ed178c092d3639ce70ae9653593acc471f9
Authors: McCloskey, Brian; Heymann, David L.
Date: 2020-02-05
DOI: 10.1017/s0950268820000254
License: cc-by
Abstract: The response to the novel coronavirus outb... | When was World Health Organization (WHO) first notified about the SARS-CoV-2 epidemic in Wuhan City, China? | false | 1,202 | {
"text": [
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1,629 | The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459876/
SHA: f0b1fa4036434b57c8307d43c39a4193f7e8053a
Authors: Morokutti-Kurz, Martina; König-Schuster, Marielle; Koller, Christiane; Graf, Chr... | What is carageenan? | false | 2,157 | {
"text": [
"a high molecular weight sulfated polymer derived from red seaweed (Rhodophyceae) that has been extensively used in food, cosmetic and pharmaceutical industry and is generally recognized as safe by the FDA"
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2,486 | Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
https://doi.org/10.3390/jcm9030623
SHA: 9b0c87f808b1b66f2937d7a7acb524a756b6113b
Authors: Pang, Junxiong; Wang, Min Xian; Ang, Ian Yi Han; Tan, Sharon Hui Xuan; Lewis, Ruth Frances; Chen, Jacinta I. Pei;... | What is the limitation in virus testing? | false | 3,663 | {
"text": [
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1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | How does MERS-CoV compare with SARS-CoV? | false | 4,204 | {
"text": [
"MERS kills its human host more often than SARS did (20-40 % versus 9 % for SARS"
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2,669 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
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Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | What does the author anticipate international efforts will do? | false | 4,134 | {
"text": [
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1,566 | Aetiology of Acute Respiratory Tract Infections in Hospitalised Children in Cyprus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720120/
SHA: efd27ff0ac04dd60838266386aaebb5df80f4fa9
Authors: Richter, Jan; Panayiotou, Christakis; Tryfonos, Christina; Koptides, Dana; Koliou, Maria; Kalogirou, Nikolas; Georgiou, Eleni... | What is the most common viral infection for infants up to 3 months old? | false | 1,629 | {
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1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What diminishes the effectiveness of annual influenza vaccinations? | false | 1,241 | {
"text": [
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1,557 | Changes in pulmonary tuberculosis prevalence: evidence from the 2010 population survey in a populous province of China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890533/
SHA: eef61bdfa49b8652fd660b5b8b7e74cf51922505
Authors: Wei, Xiaolin; Zhang, Xiulei; Yin, Jia; Walley, John; Beanland, Rachel; Zou, Guanyang; Zha... | How many people were in a community cluster? | false | 3,021 | {
"text": [
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1,566 | Aetiology of Acute Respiratory Tract Infections in Hospitalised Children in Cyprus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720120/
SHA: efd27ff0ac04dd60838266386aaebb5df80f4fa9
Authors: Richter, Jan; Panayiotou, Christakis; Tryfonos, Christina; Koptides, Dana; Koliou, Maria; Kalogirou, Nikolas; Georgiou, Eleni... | When do respiratory infections usually happen? | false | 1,613 | {
"text": [
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1,690 | Viruses and Evolution – Viruses First? A Personal Perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433886/
SHA: f3b9fc0f8e0a431366196d3e835e1ec368b379d1
Authors: Moelling, Karin; Broecker, Felix
Date: 2019-03-19
DOI: 10.3389/fmicb.2019.00523
License: cc-by
Abstract: The discovery of exoplanets within putat... | What are some examples of autonomous bacteria that lost their independence and became intracellular parasites or endosymbionts? | false | 1,178 | {
"text": [
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1,570 | Identification and characterisation of the CD40-ligand of Sigmodon hispidus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063397/
SHA: edf2997357501734a93c1b7e16d44e86a7d20853
Authors: Russell, Marsha S.; Muralidharan, Abenaya; Larocque, Louise; Cao, Jingxin; Deschambault, Yvon; Varga, Jessie; Thulasi Raman, Sathya ... | What is the effect of CD40L on Dendritic Cells? | false | 1,633 | {
"text": [
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1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
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Abstract: The continued emergence and re-emergenc... | What may alter population disease dynamics and lead to the emergence of zoonotic infections? | false | 4,453 | {
"text": [
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2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What are the effects for patients with COPD and patients with CRS without nasal polyp (CRSsNP) ? | false | 3,947 | {
"text": [
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1,664 | Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742597/
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Authors: Siemens, Nikolai; Oehmcke-Hecht, Sonja; Mettenleiter, Thomas C.; Kreikemeyer, Bernd; Valentin-Weigand, Peter; H... | What is Pneumolysin? | false | 5,180 | {
"text": [
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2,519 | Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054964/
SHA: 77b0c98d1a2ca46b219ad090074814c387c80d8f
Authors: Chen, Weilie; Lan, Yun; Yuan, Xiaozhen; Deng, Xilong; Li, Yueping; Cai, Xiaoli; Li, Liya; He, Ruiying; Tan, Yizh... | What illness is caused by the 2019-nCOV Coronavirus? | false | 1,149 | {
"text": [
"The novel coronavirus (2019-nCoV) infection caused pneumonia."
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1,661 | Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499828/
SHA: f4f75af02b7226c5b2363de1a75821a4b9b20412
Authors: Nicasio, Mancini; Sautto, Giuseppe; Clementi, Nicola; Diotti, Roberta A.; Criscuolo, Elena; Ca... | An antibody response to which proteins correlates with reduced HCV levels? | false | 5,168 | {
"text": [
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1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What is an important feature of the replicon system? | false | 1,568 | {
"text": [
"the self-replicating nature of the RNA. Despite the partial viral genome, the RNAs are self-replicating and can express transgenes at very high levels"
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1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | How were the transmission circumstances created? | false | 4,377 | {
"text": [
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2,668 | 2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081861/
SHA: f323af9a07cc54faf9bdbabadaacb0e8b46f99a2
Authors: Koenig, Kristi L.; Beÿ, Christian K.; McDonald, Eric C.
Date: 2020-01-31
DOI: 10.5811/westjem.2020.1.46760
License: cc-... | Who is at greater risk of dying from COVID19? | false | 2,195 | {
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1,592 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | Why is the substitution E62D important in drug resistance? | false | 3,902 | {
"text": [
"confers a higher level of resistance than the one achieved by the RAS alone"
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1,595 | Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828/
SHA: f02d0c1e8b0109648e578662dc250abe349a033c
Authors: Chen, I-Yin; Moriyama, Miyu; Chang, Ming-Fu; Ichinohe, Takeshi
Date: 2019-01-29
DOI: 10.3389/fmicb.2019.00050
Licens... | What regulates the secretion of proinflammatory cytokines? | false | 279 | {
"text": [
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2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | What is the estimated attack rate in Italy? | false | 840 | {
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187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | How many surgical masks or respirators have past studies projected will be required for a pandemic in the United States? | false | 257 | {
"text": [
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1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What is the advantage of the adenovirus ? | false | 1,506 | {
"text": [
"is a non-enveloped virus which is relatively stable and can be formulated for long-term storage at 4 °C, or even storage up to six months at room temperature"
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1,674 | Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523942/
SHA: f00f183d0bce0091a02349ec1eab44a76dad9bc4
Authors: Henry, Kevin A.; Arbabi-Ghahroudi, Mehdi; Scott, Jam... | What does the term "phage display" refer to? | false | 1,736 | {
"text": [
"a recombinant filamentous phage displaying a single polypeptide sequence on its surface (or more rarely, bispecific display achieved via fusion of polypeptides to two different capsid proteins)"
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1,645 | Pre-existing immunity against vaccine vectors – friend or foe?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542731/
SHA: f5bdf18567bb3760e1ce05008135f0270badbd5c
Authors: Saxena, Manvendra; Van, Thi Thu Hao; Baird, Fiona J.; Coloe, Peter J.; Smooker, Peter M.
Date: 2013-01-27
DOI: 10.1099/mic.0.049601-0
License: cc... | What are important criteria for selecting vaccine delivery vectors? | false | 841 | {
"text": [
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1,671 | Host resilience to emerging coronaviruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079962/
SHA: f7cfc37ea164f16393d7f4f3f2b32214dea1ded4
Authors: Jamieson, Amanda M
Date: 2016-07-01
DOI: 10.2217/fvl-2016-0060
License: cc-by
Abstract: Recently, two coronaviruses, severe acute respiratory syndrome coronavirus an... | What is the timeline of the type I interferon (IFN) response in SARS-CoV infection? | false | 1,272 | {
"text": [
"In a mouse model of SARS-CoV infection, the type I IFN response is delayed"
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1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | Who accounted for 44% of HMPV positive cases in Kenya between 2007 and 2011? | false | 4,067 | {
"text": [
"children under 6 months of age"
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"answer_start": [
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1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | What is the detection of MERS-CoV infection using ELISA or S1 subunit protein microarray [84] is usually followed by? | false | 4,240 | {
"text": [
"by confirmatory IFA and/ or a plaque-reduction neutralization (PRNT) [69, 70, 85] or MNT test."
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1,629 | The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459876/
SHA: f0b1fa4036434b57c8307d43c39a4193f7e8053a
Authors: Morokutti-Kurz, Martina; König-Schuster, Marielle; Koller, Christiane; Graf, Chr... | What is the association between influenza viral load and carageenan? | false | 2,160 | {
"text": [
"a significant reduction of the influenza viral load in nasal fluids and a significant increase in the number of virus free patients within the treatment period of 7 days"
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1,573 | Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048719/
SHA: f2f78c95ab378a31bd35dc1de84e0ec75eb7ce1b
Authors: Liu, Wen-Kuan; Liu, Qi... | What are the symptoms of HBoV1 infection? | false | 3,271 | {
"text": [
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1,671 | Host resilience to emerging coronaviruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079962/
SHA: f7cfc37ea164f16393d7f4f3f2b32214dea1ded4
Authors: Jamieson, Amanda M
Date: 2016-07-01
DOI: 10.2217/fvl-2016-0060
License: cc-by
Abstract: Recently, two coronaviruses, severe acute respiratory syndrome coronavirus an... | What was the primary threatening clinical finding in patients infected with SARS-CoV and MERS-CoV? | false | 1,260 | {
"text": [
"severe lung pathology"
],
"answer_start": [
2395
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} |
1,740 | The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013893/
SHA: f13c88733ea45be9e923a282dfd42f8c277c187c
Authors: Lambkin-Williams, Rob; Noulin, Nicolas; Mann, Alex; Catchpole, Andrew; Gilbert, Anthony S... | What are the 2 surface proteins on the H1N1 influenza virus? | false | 320 | {
"text": [
"haemagglutinin (HA) and the neuraminidase (NA)"
],
"answer_start": [
12737
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} |
2,463 | SARS to novel coronavirus – old lessons and new lessons
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026896/
SHA: 5d254ed178c092d3639ce70ae9653593acc471f9
Authors: McCloskey, Brian; Heymann, David L.
Date: 2020-02-05
DOI: 10.1017/s0950268820000254
License: cc-by
Abstract: The response to the novel coronavirus outb... | What type of test was initially developed to screen for SARS-CoV-2? | false | 1,205 | {
"text": [
"reverse transcription polymerase chain reaction"
],
"answer_start": [
1445
]
} |
188 | The Battle Against Coronavirus Disease 2019 (COVID-19): Emergency Management
and Infection Control in a Radiology Department
https://www.jacr.org/article/S1546-1440(20)30285-4/pdf
Journal Pre-proof
Zixing Huang, Shuang Zhao, Zhenlin Li, Weixia Chen, Lihong Zhao, Lipeng Deng, Bin
Song
PII: S1546-1440(20)30285-4
DOI: htt... | How many people have come in contact and how many of these are in observation? | false | 2,465 | {
"text": [
"677,243 people have been identified as having had close contact with\ninfected patients of whom13,701"
],
"answer_start": [
4931
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} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | What do patients often present to a hospital with, in cases of MERS? | false | 4,223 | {
"text": [
"pneumonia"
],
"answer_start": [
8621
]
} |
2,432 | Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090843/
SHA: 0a08fddd9dcee1b1254a05b49113521bbc423ccd
Authors: Lai, Jianbo; Ma, Simeng; Wang, Ying; Cai, Zhongxiang; Hu, Jianbo; Wei, Ning; Wu, Jiang; Du, Hui; Ch... | What were the Generalized Anxiety Disorder scale scores? | false | 3,463 | {
"text": [
"among men vs women: 2.0 [0-6.0] vs 4.0 [1.0-7.0]; P < .001"
],
"answer_start": [
2530
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} |
1,690 | Viruses and Evolution – Viruses First? A Personal Perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433886/
SHA: f3b9fc0f8e0a431366196d3e835e1ec368b379d1
Authors: Moelling, Karin; Broecker, Felix
Date: 2019-03-19
DOI: 10.3389/fmicb.2019.00523
License: cc-by
Abstract: The discovery of exoplanets within putat... | Which group of RNA quasispecies satisfy criteria for life? | false | 1,180 | {
"text": [
"catalytically active members, enzymatically active ribozymes. The sequence space for 220-mer RNAs is about 3 × 10 132 ("
],
"answer_start": [
2682
]
} |
2,620 | Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak
https://doi.org/10.3390/jcm9020388
SHA: bf20dda99538a594eafc258553634fd9195104cb
Authors: Zhao, Shi; Musa, Salihu S.; Lin, Qianying; Ran, Jinjun; ... | What is the likely period of under-reporting? | false | 1,881 | {
"text": [
"to have occurred during the first ha"
],
"answer_start": [
1865
]
} |
1,687 | Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na(+)/K(+) transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834214/
SHA: efbd0dfc426da5dd25ce29411d... | What factors did this study attribute to the efficient multiplication of mammarenaviruses? | false | 5,158 | {
"text": [
"ATP1A1 and PHB"
],
"answer_start": [
34103
]
} |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What tests can simultaneously identify and subtype multiple respiratory viruses? | false | 4,081 | {
"text": [
"multilocus polymerase chain reaction coupled with electrospray ionization mass spectrometry"
],
"answer_start": [
4633
]
} |
2,642 | First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068164/
SHA: ce358c18aac69fc83c7b2e9a7dca4a43b0f60e2e
Authors: Spiteri, Gianfranco; Fielding, James; Diercke, Michaela; Campese, Christine; Enouf, Vincent; Gayma... | What other data on pre-existing conditions were reported? | false | 3,825 | {
"text": [
"one was reported to be obese and one had pre-existing cardiac disease. No data on clinical signs e.g. dyspnea etc. were reported for any of the 38 cases."
],
"answer_start": [
7931
]
} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | What is the time-varying reproduction number a function of? | false | 1,095 | {
"text": [
"initial reproduction number before interventions and the effect sizes from\ninterventions"
],
"answer_start": [
33246
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | For HCPS, what does that expression favor? | false | 4,551 | {
"text": [
"the pulmonary bed and lymphoid organs"
],
"answer_start": [
16823
]
} |
1,557 | Changes in pulmonary tuberculosis prevalence: evidence from the 2010 population survey in a populous province of China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890533/
SHA: eef61bdfa49b8652fd660b5b8b7e74cf51922505
Authors: Wei, Xiaolin; Zhang, Xiulei; Yin, Jia; Walley, John; Beanland, Rachel; Zou, Guanyang; Zha... | What was the response rate for the study? | false | 3,026 | {
"text": [
"95% to 97%"
],
"answer_start": [
9615
]
} |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | How does gender influence MERS-COV infection? | false | 559 | {
"text": [
"MERS-CoV infects males more than females"
],
"answer_start": [
2869
]
} |
2,684 | 1918 Influenza: the Mother of All Pandemics
Jeffery K. Taubenberger" and David M. Morens1-
The “Spanish" influenza pandemic of 1918—1919,
which caused :50 million deaths worldwide, remains an
ominous warning to public health. Many questions about its
origins, its unusual epidemiologic features, and the basis of
its p... | What was the death toll in the 1918-1919 Spanish Influenza epidemic? | false | 1,060 | {
"text": [
"Total deaths were estimated at\nz50 million (577) and were arguably as high as 100 mil-\nlion"
],
"answer_start": [
1284
]
} |
1,600 | The influenza pandemic preparedness planning tool InfluSim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832202/
SHA: f3f471d10a36a7a28e9050c10bd4dfd680cba17b
Authors: Eichner, Martin; Schwehm, Markus; Duerr, Hans-Peter; Brockmann, Stefan O
Date: 2007-03-13
DOI: 10.1186/1471-2334-7-17
License: cc-by
Abstract: BACKG... | What are the limitations of a deterministic model? | false | 5,255 | {
"text": [
"cannot reliably represent effects originating from stochasticity, from effects in small populations, or from heterogeneities"
],
"answer_start": [
10476
]
} |
2,486 | Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
https://doi.org/10.3390/jcm9030623
SHA: 9b0c87f808b1b66f2937d7a7acb524a756b6113b
Authors: Pang, Junxiong; Wang, Min Xian; Ang, Ian Yi Han; Tan, Sharon Hui Xuan; Lewis, Ruth Frances; Chen, Jacinta I. Pei;... | Which electronic databases were used for this study? | false | 3,627 | {
"text": [
"PubMed, Embase and Cochrane Library"
],
"answer_start": [
4516
]
} |
1,645 | Pre-existing immunity against vaccine vectors – friend or foe?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542731/
SHA: f5bdf18567bb3760e1ce05008135f0270badbd5c
Authors: Saxena, Manvendra; Van, Thi Thu Hao; Baird, Fiona J.; Coloe, Peter J.; Smooker, Peter M.
Date: 2013-01-27
DOI: 10.1099/mic.0.049601-0
License: cc... | Which bacteial delivery vectors have gained favor for vaccines? | false | 804 | {
"text": [
"Bacteria such as E. coli and lactic acid bacteria"
],
"answer_start": [
2079
]
} |
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