Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
P33401 | 5.4.2.2 | ACT_SITE 120; /note="Phosphoserine intermediate"; /evidence="ECO:0000250|UniProtKB:P00949" | MSLLIDSVPTVAYKDQKPGTSGLRKKTKVFMDEPHYTENFIQATMQSIPNGSEGTTLVVGGDGRFYNDVIMNKIAAVGAANGVRKLVIGQGGLLSTPAASHIIRTYEEKCTGGGIILTASHNPGGPENDLGIKYNLPNGGPAPESVTNAIWEASKKLTHYKIIKNFPKLNLNKLGKNQKYGPLLVDIIDPAKAYVQFLKEIFDFDLIKSFLAKQRKDKGWKLLFDSLNGITGPYGKAIFVDEFGLPAEEVLQNWHPLPDFGGLHPDPNLTYARTLVDRVDREKIAFGAASDGDGDRNMIYGYGPAFVSPGDSVAIIAEYA... | 216 |
O74384 | 2.3.1.225 | ACT_SITE 212; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q8VDZ4" | MSYEKHSDAKASRYAWNQPWNPFEVTLSDPTYPMNLEEKNQIPYRFQSVPDDVPEVPHIESRYKNLPGNNIYLCCGRLQMSSQYKAFLISLFALILPGVLFFIFSAFWLWHHVSPAVPITFAYLYALAVVSMFKCSTADPGILPRNAYSLTYNPAHPWSVIPEDRKVLVGSTRSDSVFVNTVYCHTCHLYRPPRASHCHLCDNCVEYLDHHCIWLNTCIGRRNYRYYFIFLLSVVLSALYLTGLGFYTSIGSFHESTDTNFAAHLRRPWAGVSFFLGIYGALGAILPGILFCYQCYLISVGQNVHEYLRAKSTETEDVHP... | 57 |
A0A8J0TKL1 | 3.1.3.16 | ACT_SITE 313; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MSQCRDVLTVTGSGNMAEAERAIEAGGEPASNREKTAEELKEQANEYFRVKDYDNAVQYYTQAIALSPDTAIYYGNRSLAYLRTECYGYALADASRAIQLDAKYIKGYYRRAASNMALGKLKAALKDYETVVKVRPHDKDAQMKFQECSKLVRQKAFERAIACEQHNRSVVDSLDIEGMTIEDEYTGPQLKDGNVTMDFMLELMQFYKDQKKLHRKCVYQMLVQVKDILSKLPSLVELSLEKSQQVTVCGDTHGQFYDLMNIFHLNGLPSENNPYIFNGDFVDRGSFSVEVIVTLFGFKLLYPAHFHLLRGNHETDTMNQ... | 144 |
C5XI24 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKLSAAVLCALVAVQAAALLLATVPSAQAKELEVGYYGKKCKGVENVVKWHVIKAIKANRRTGAALVRLLFHDCFVRGCDGSVLLDASSDNPHPEKEAPVNIGLAAFDVLEEIKAAVEKRCPGVVSCSDILIYAARDAASALSNGHVHFAVPAGRLDGFVSKADEAQAELPDSTHDVQQLIDNFARKNFTVEELVILTGAHSIGQGHCSSFRGRLSEPSSQITPAYRDLLNYKCSQGSNPPVDNNVRDEDYDVVAKFVAGFTSRVRKIPDFLDNSFYHNNLAKIVTFHSDWTLLTHKEALGHVVEYAENGTLWDEDFSES... | 14 |
Q8X176 | 3.1.3.2 | ACT_SITE 215; /note="Proton donor"; /evidence="ECO:0000250" | MKPSVATLLATVSLVYAQTATEKEPSLSAIESAAASIQPYSPVSNVEGVAFNRFFQVWLENIDYEDAAADENMKWLASQGILLTNFYAVTHPSEPNYCAAVGGDTFGMDNDNFNQIPANVSTVADLLDTKNIAWGEYQEHLPYPGFQGFNYSNQETYVNDYVRKHNPLVLYDSVTKNSTRLRQIKNFTSFEDDLANKKLPQWAFITPNMTNDAHDTNITFGAKWERSWIAPLLNNSYFMNDTLILLTFDEDGTYSKSNKIFSVLLGGAIPDELKGTQDDTFYTHYSVIASVSANWGLPSLGRWDCGANILEIVANKTGYV... | 145 |
D6X165 | 2.7.11.1 | ACT_SITE 179; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MSFREENVDIMAENFLKSVKIPSELKKPTTNLVKKMMSHDCYANPDYEWSLNDFELGRRLGRGKFGRVFIAREKKTGLIVALKTLLKKEIVEGGVEKQILREIEIQSHLKHPNILQLLCWFHDSHRIYLAVDYAGKGELYKHLQAGMGGHFTEKEAAKYTYQVADAVNYCHKKCVIHRDIKPENLLLTYEGNVKLADFGWSVHSPSLQRDTMCGTLDYLPPEMVEHRRYGKYVDHWCLGVLCYEFLVGYPPFESKTSEETYHKIRHVDLKFPEDVPSGARDLISKLLTRSSHKRMSLNDVMCHPWIVRNK | 99 |
A0BR89 | 2.7.11.1 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MRKKRALNEFEFVEKKDNGKAQEELGKGAFGRVRLAIDKLTDTKVAIKTIPKKLLKENAQAENIKREIKLHRKLDHPHIVKLYHSLEDDTNVYLVLEYVPMGNLFVYLRKRKNLEEQEAFVYFLQTALAIDYLHKKGIIHRDLKPENILLDAQGNIKICDFGWSAELQPERRTFCGTLDYMCPEMLNSQSHDHRIDIWAMGVLLFEMLHGHAPYNKNRSSQEVVIQAILNAATTKIPFNDKISNDVKDLISSLLRVNPKDRLSMDEIFTHKWVKTNAKALQINIPEFVYEKGVNETVQSIQDISIDFTNLTQPSNNYQSQ... | 99 |
A0A251U761 | 3.4.19.12 | ACT_SITE 121; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 196; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MLVNWICPPSSPFLTLLANFLLTPSSIASKQTQINLQSCLGAPLNLIPVCVFTELIQQMQVKGVQVEELYSLDLDSLNSLRPVYGLIFLFKWRAGEKDERLVIKDPNPNLFFASQVINNACATQAILSILMNCPEVDIGPELSALKEFSKAFPPELKGLAINNSDAIRTAHNSFARPEPFIPDEQKAAGKDDDVYHFISYIPVDGVLYELDGLKEGPISLGPCSGGQGDMDWLKVVQPVIQERIERYSQSEIRFNLMAIIKNRKEMYTAELKELQRRRERLLQQLAALQSERVVDGGNVEALNKSLYEVNAGIEGATEKI... | 175 |
A0A7M7HM90 | 3.1.1.4 | ACT_SITE 77; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 134; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MELLLRVLVMTSLLLARTTSENGKLQRVDEQNFVQFAVMVTCATSLPGFLFNDYGCHCGLGGKGTPVDGVDRCCQIHDECYDSIIAGVCRNDIVYLTTYKYTCKYRWPWSSASSSITCDSSKNDACRQSLCECDRNAALCFARSKYNIGNTFYDKNAKC | 130 |
W5NFM1 | 5.1.3.3 | ACT_SITE 185; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 319; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | GTAARGGLTPQTEVTKTEFGVVPGQGSVDKFQLKSQDVTLEVISLGCIITSLKTKNKRGEFDDIVLGFDNLEGYLSNPACFGAVVGRVANRIAKGKFTVDGKDYQLAINNGPNSLHGGLKGFNKAIWTSEVLLSGVRFCLTSPDGDEGYPGELRASVTYVLEGEVLSIHYKAETSKTTPVNLTNHSYFNLAGHGTPDIYDHEVSITADAYLPVDDTMIPTGEIAPVQDSLFDLRKPVLIGQRLKELADPGFDHNFCLSSPGDPWLVRPCARVTHPGSGRVLDVHTSQPGVQLYTANFLDGSLRGKAAAAYPRHSAFCLET... | 211 |
A0A8J1L8K7 | 2.7.10.1 | ACT_SITE 740; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MAPRLTCLLCVCFSLAPRSAPTSNEVNLLETATIPGDWGWLTSPPHGWDSISEMDEFFRPIHTYQVCNVMSPNQNNWLRTNWVQREGARRVYVEIKFTLRDCNSMPGVSGTCKETFNLYYLETDRDLGSSTTETQFMKIDTIAADESFTNVDLGVRRLKLNTEVRGVGPLTRRGFYLAFQDIGGCIAIVSVRVYYKKCPPMVRNLAAFSEAITGSDSSSLVEVQGECVGNSEERDPPKMYCSSEGEWLVPIGKCVCSAGFEERSDSCVACDLGYYKSFPGDQPCSKCPPFSHSETLAARLCPCDTNYYRSASDSPSAPCT... | 97 |
G1K8Z9 | 2.7.11.25 | ACT_SITE 278; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50" | MACLHETRTPSPSFGSFNTILAESSLRKLDPDASDCTPEKDLTPTQCVLRDVLPIDGGGGGGGGHSPTPSEETHDQFANSVLQLHENEAGGHGGGSGAGAGAGAGNPEVRATRYHADQVRLHCQSGSGFLEGLFGCLKPVWTMIGKAYSTEHKQQQEDPWEVPFEEIMDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDFKETDIKHLRKLKHPNIITFKGVCTQAPCYCIIMEFCAQGQLYEVLRAGRKVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMA... | 105 |
Q8YA23 | 2.2.1.1 | ACT_SITE 411; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MSRIDEQMVNSIRVLSMDMIEKANSGHPGLPMGAAPMAFSLWKNHLKFNPEHPTWFNRDRFVLSAGHGSAMLYSLLHLFGYDLPMSELKNFRQTGSKTPGHPEFGHTVGVDATTGPLGQGFAMGVGMAMAEAHLGAKFNQPEFPVVDHNTYVLCGDGCLMEGISYEAASLAGHLKLGKLVVLYDSNDISLDGDLNESFSEDIELRFRAAGWQTLRVDDGNDLDALDAAIHLAKTEKSRPTLIEVKTVIGYGSPGKAGKSAAHGSPLGEKELKLAKEAYDWQMPPFELPKTVENQKEFYHSKGRASESSWLRTFNAYKQKY... | 51 |
B8E2R2 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRRKIIAANWKMYKTCAETESFIKEFKELSKGYEEKEIVICPPFTSLYVANKLLEDTPIKLGAQNMFWEKEGAYTGEISPIMLKDLNCSYVIIGHSERRQYFSETNDMINKKLKSAFEYELIPIFCVGEKWEEREKGKTEEVITEQVKKGLQGLEKEKVEKIVIAYEPVWAIGTGHSAKGEDANEVAKLIRRIISEIYDEEVSQKVRIQYGGSVNPQNIKEFLAQSEIDGALVGGASLKPQSFWDIVRS | 213 |
F7CXU6 | 2.7.11.25 | ACT_SITE 279; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50" | MSSPQEQLSWSSSPTLTLSENRAFGGLHDERTSPRSHPSPKLFEDVEEKGVLRAELTEGMTSPTATTALTSVSEDSRDQFENSVLQLREQEESESATSQGNGNAGDGENTGSTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKVTPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWM... | 105 |
Q2RAS0 | 7.2.2.10 | ACT_SITE 434; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250" | MEKLDRYLQEHFDVPAKNPSEEAQRRWRQAVGTIVKNRRRRFRWVPDLDRRSLDKAKVRSTQEKIRVALYVQQAALIFSDDELALITSKHDSKALKMHGGVDGISKKVRSSFDHGICASDLDTRQNIYGVNRYAEKPSRSFWMFVWDAFQDMTLIILMVCALLSVAVGLATEGWPKGMYDGLGIILSIFLVVMVTAVSDYKQSLQFKELDNEKKKIFIHVTRDGRRQKISIYDLVVGDIVHLSIGDQVPADGLYIHGYSLLIDESSLSGESDPVYVSQDKPFILAGTKVQDGSAKMIVTAVGMRTEWGKLMSTLSEGGED... | 258 |
A0A067H4S3 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSYAKMDSCMIMCILILVSTMPLGTSANAKLKVGFYKSTCPSAESIVRKAVNKAVSCNPGIAAGLIRMHFHDCFVRGCDASVLLETIPGNPPSERDDHVNNPSLRGFEVIDEAKAQIEAVCPNTVSCADILTFAARDSTSKVGGINYAVPAGRRDGRVSLSNEIAENLPSPTFNAEQLAARFARKGISVDEMVTLVGAHSIGVSHCSSFSKRLYAFNTTHPQDPSMDHRFANFLKNKCPPPPPTDGLGCTRDPTVTQEFVTPNRLDNKYYRELRNHRGLLTSDQTLMDSRLTSKMVLDNERNGAMWGTKFAKAMVHVGSL... | 14 |
A0A7M7PTK4 | 2.7.11.1 | ACT_SITE 161; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 525; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MAQAYVEDTLMVRHELKHANLTGHAEKVGRENFELLKVLGTGAYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREHFRESEVRIYIAEIIIALDCLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFLTNTEDRAYSFCGTIEYMAPEVVRGGSDGHNKAVDWWSLGVLTYELLTGASPFTVEGERNSQSQISQRILTSHPPMPNTFSKEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFFKGLNWDDVAAKRVSPPFRPH... | 99 |
Q8THT3 | 3.1.3.3 | ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 15; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MHNSTENKLIVFDMDSTLIDAETIDELARAAGVISKVEEITKRAMYGDLDFEQALAERARLLKGLSLETALDAVDQINLMPGAAELVLYVKQLGYKTAMISGGFTIAAERIGKTLGIDFVVSNELLMEDGCLTGEVVGPVTQSDSKAKVFEELAWLYNIRPDQCVVVGDGANDACIFEIAGFAIAFNPKPILREYADVVITIKDLRAVIPVLESLSYQCCNQAQHVDIEHY | 147 |
A0A2K1IBX1 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRWPSPALLAIFVTIALAMNSIIPAAAHTGLKVGFYRHSCPQVEAIVYNSMAQSTKADDTVAPGILRMAFHDCFVRGCDASVLLEGPNTERRARTNTGLHGFDAIDAAKRAVENACPGVVSAADVLQFAARDAVVLAGGYGWHVPAGRRDGTVSIMEEALNLPAPSMTVSQLIDVFGRKGLSPSQMVVLSGAHTIGKAPCVTFDDRVQTTPVDPTLAPSFATFLKGQCPYAAIQSTSVDMDSTAHTFDSQYFKDIIAGRGLLTSDQSLLYDSRTSGGVYANNGAAFYRNFAKAMVKMSQIEVLTGLDGEIRRQFDQVNS... | 14 |
Q9LXA5 | 2.7.11.1 | ACT_SITE 459; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MANSILLFSFVLVLPFVCSVQFNISRFGSDVSEIAYQGDARANGAVELTNIDYTCRAGWATYGKQVPLWNPGTSKPSDFSTRFSFRIDTRNVGYGNYGHGFAFFLAPARIQLPPNSAGGFLGLFNGTNNQSSAFPLVYVEFDTFTNPEWDPLDVKSHVGINNNSLVSSNYTSWNATSHNQDIGRVLIFYDSARRNLSVSWTYDLTSDPLENSSLSYIIDLSKVLPSEVTIGFSATSGGVTEGNRLLSWEFSSSLELIDIKKSQNDKKGMIIGISVSGFVLLTFFITSLIVFLKRKQQKKKAEETENLTSINEDLERGAGP... | 99 |
Q5A750 | 2.2.1.1 | ACT_SITE 415; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MPSLDELTISTIRGLSVDAVSAANSGHPGAPLGLAPAAHVVWQKMKFNPKDPNWINRDRFVLSNGHACALLYSLLVLYKFELTVDDLKQFRQLGSKTPGHPEATDTAGVEVTTGPLGQGISNAVGIAIAQKQFAATYNKPDITLSDSYVYTFVGDGCLMEGVSSETSSLAGHLQLNNLIAFWDDNRISIDGDTAVSFTENVPDRYRAYGWNVLEVPDANTNIEAIAAAVDEAKKSTDKPTLIRLVTTIGYGSLKQGSHDVHGSPLKPDDIKQLKKSWGFKEDVDFFIPEEVSEYLAKHVSENQKVQKEWEAKLAEYKKKY... | 51 |
Q86IX1 | 2.7.11.1 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159" | MAIKKPINVKQLSDKLGVPILPDDPQTIYHIQERLGKGSFGQVFKAVHFANGKVVAIKIISLDDQEAIKDVRKEISILAECNYPNIVQYFGSYFKDHQLWIVMEYCGGGSVSDLLQVIDTISEDEIALICREALKGLNYLHEFKKIHRDIKGGNILLNDRGEVKLADFGVSAQLFNTFSKRNTFVGTPYWMAPEVIQENKYDGKADVWSLGITAIEMAEGLPPNSNVHPMRVIFMIPREESPALTDKSIWSDKFQDFISKCLTKDPAERPTAKELLNHEFIQTKKPLSILSDLVENCKTLINNSSMFEDEDEEEGNYSTF... | 99 |
A0A2K2BLT6 | 3.1.1.11 | ACT_SITE 395; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYPTRGRTKHLLFLLPISILVITLLSFKRPAKFSSKTIEIPRLHIHKHIQIAHSACKGTLYPELCVSTLVSLPDLASKSLQEFISATLNKTMDEVRASSADCNAIRNKMKLGPLEKVALKDCIELFDDTIAELKSAISNLALRKPTSKHYHDLQTLLSGAMTNQYTCLDGFARSKGKVRKAIKKGLYNISHHVSNSLAMLKKIPGVNASKSEVFPEYGNVKHGFPSWLSTKDRKLLQASANATKFDLIVAKDGTGNFTTISEAVRAAPNSSDTRFVIHIKAGAYFENVEVERKKKMLVFIGDGIGKTVVKANRSVVDGWT... | 125 |
A0A0K9NVQ6 | 3.1.1.11 | ACT_SITE 369; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAKMNFCLLLLFLATVSSSFAFSENSDCTLRHAQILCDGTLYPDLCVSTVVAIPNVESMTLSEVISHTISQTADKVGYSTSDCASFLRNEYFSLNHEQRLCITDCLELLQITVEELQDAIISSTDHIHDLQNFLTAAITNQYTCLDGFAMAFNGSVPDWLNVGLTNISQLVSNSLAMTNKVPQKDKTVLQDFSEGSFPSWVPQKNQKLFQTPVDSIKIDLVVSQDGTGDFMTINDAVAAAPNKSDSTFVIYIKTGGYFENVVVDSNKHNLMFVGDGMWKTVVKSDRNNVDGWPTYCSATVSVLGYRFQARDMTFENTAG... | 125 |
Q865C0 | 4.2.1.1 | ACT_SITE 85; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P00918" | MRALALLLALPLLGARAQHGSLWTYSEGALDQVHWPREYPTCGGTRQSPIDLQRRKVQYNPSLKALKLTGYRIQVGEFPMINNGHTVQISLPPTMRMMASDGTEYIAQQMHFHWGGASSEISGSEHTIDGIRFVAEIHIVHYNSKYKSYDIAQHEPDGLAVLAALVKVEDYGENTYYSNFISHLNNIRYPGQSTVLSGLDIEDMLPENTHHYYTYRGSLTTPPCTENVHWFVLVHHVRLSSIQTWKLENSILDHQNKTLHSDYRRIQPLNGRVVESNFVNLPSQGSEFQFYVNKLNNKLEYLRRLLEKTKVEKKPHIHQA | 199 |
A0A2K1L1P8 | 3.1.3.48 | ACT_SITE 192; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 194; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MDLQLPRQDASTPLPAASSTRPLAPPPAPSSPPSLCQAKRARLTPMSDQILSGMANNDEGVGPVYDPHSNNLKETPRTEKLSGISALPNETNGLQPNNEEHLLDSKIIHSKYTEEQLAAEPLLGIAEWLNCAPAALTSPPPPKYHSPKSGGSDRSEDINEVRSGSETPPKLPEVEGSTRPVKSTDPTLYVWDLDETLIIFQTLRNGRYAELYKGSKDPREACELGRRWESLILDICDDYFFYKQVENYNEPSLLSLQDFDDGADLSQYNFDGDNLTVPVDTANKNKLAYRHRFIGELYEKGLEKLLTQDQLTEWNNLYEA... | 149 |
A0A1S4AG36 | 3.1.1.11 | ACT_SITE 247; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNTTRRTIFFWFIAFTIALFSIIFPLYSNYNSPTNNAIESTSFPLALLKRVVEKSGLQDFFCIFQEITRLHNSKCDDSKWNSKLISVYGVSHVLTVDLNGCANFSSIQKAVDAVPDDNPTRTLILVDSGTYKEKVVINTNKTNLIIQGQGYLNTAIAWNDTANSTGGTANSFTVAIYAPNFIAYNISFQNTAPSASPGDVGAQAVALRVTGDEVAFYGCGFYGAQDTLNDDRGRHYFKDCFIQGSIDFIFGNGRSLYEDCRINSIAKEETGGIGGSITAQGRNSQNENSGFSFVNCAINGSGKIWLGRAWGAYATVVFSK... | 125 |
Q9Z528 | 5.4.99.25 | ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MTEKHTTPDGLVIVDKPSGFTSHDVVAKMRGIARTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTIRLGQTTLTDDAEGEITGSRDASKVTWEAIDAGVAELSGDIMQVPSKVSAIKIKGVRSYKRAREGEEFEIPARPVTVSSFAVYDVRDAVADDGTPVLDLVVSVTCSSGTYIRALARDLGAGLGVGGHLTALRRTRVGPYKLDGARTLDQLQQELTVMPVADAAGAAFPRWGVDARRARLLANGVRLEMPEEYTGVGAVAVFDPEGRLLALVEEHKGKAKSLAVFG | 218 |
B3RR73 | 3.1.3.1 | ACT_SITE 73; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MNGYSKTKLLDTGGKRVILAIGDGMSLTTVTTARILQGQQKGKTGEEEQLSWEKFPFTGLSKTYNVDYQVPDSAGTATAFLCGVKTDAGIIGLDENSVRGDCAASKGTEVGSILKLAKQAGLSVGIVVTARITHATPSSSYAHCPERNWEGSVPSLAEQQGCIDIAQQFINFQKEHGGISVALGGGRRNFIPNTQNDVEYPNTKGRRVDGKDLIQEWKNLQLQNSAYVWNLSDFNAIDPKKTDHLFGLFEPSHMQYESARNKGPSGEPSISEMTRKAIQILERNPKGYFLLIESGRIDHGHHEGSAYKALTEAVALAQAV... | 141 |
A8Y0F0 | 1.8.1.4 | ACT_SITE 472; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MSLSRTSQLPFAKRQFFQILARSYSNTQDADLVVIGGGPGGYVAAIKAAQLGMKTVCVEKNATLGGTCLNVGCIPSKALLNNSHLLHQAQHDFAARGIDCTASLNLPKMMEAKATSVKQLTGGIKQLFKANKVGHVEGFGTIVGPNTVQAKKADGSVETINARNILIASGSEVTPFPGITIDEQSIVSSTGALSLGQVPKKMVVIGAGVIGLELGSVWQRLGAEVTAVEFLGHVGGMGIDGEVSKNFQRTLTKQGFKFLLNTKVLGATKNGSNISVEVEGAKDGKKQTLECDTLLVSVGRRPYTEGLGLSNVQIDTDNRG... | 36 |
P34208 | 2.7.11.1 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAQKLDNFPYHIGREIGTGAFASVRLCYDDNAKIYAVKFVNKKHATSCMNAGVWARRMASEIQLHKLCNGHKNIIHFYNTAENPQWRWVVLEFAQGGDLFDKIEPDVGIDEDVAQFYFAQLMEGISFMHSKGVAHRDLKPENILLDYNGNLKISDFGFASLFSYKGKSRLLNSPVGSPPYAAPEITQQYDGSKVDVWSCGIILFALLLGNTPWDEAISNTGDYLLYKKQCERPSYHPWNLLSPGAYSIITGMLRSDPFKRYSVKHVVQHPWLTSSTPFRTKNGNCADPVALASRLMLKLRIDLDKPRLASSRASQNDSGF... | 99 |
A0A1S3XL53 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPTNSSQPLLVDTPKRKSSPSKALYVLLSLAAIVGSVGLVSIWAINGSSPSTSLTADVCDQAHDQPSCLTMMSEVAPAGSMNSKTVDLLQMVLHKSSLKIHETIDLVRNVNSRINNDKEQAALADCLELMDLSRDRLMDSMMSLGNLSSQAHFDVHTWLSSILTNHVTCKDGLNAQAQSIMKPMLKDLIARAKTSLALMVKMAPSNTMDLPSVTDGMPSWVTSNDRRLLQLSANAITANVVVAKDGSGKFKTVKEAVASAPDNGKTRYVIYVKKGIYKENVEIGKKKKNVMLVGDGMDTTIITGNLNVVDGATTFNSATV... | 125 |
Q9LDA4 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297, ECO:0000255|PROSITE-ProRule:PRU10012" | MHSSLIKLGFLLLLLQVSLSHAQLSPSFYDKTCPQVFDIVTNTIVNALRSDPRIAASILRLHFHDCFVNGCDASILLDNTTSFRTEKDAFGNANSARGFDVIDKMKAAIEKACPRTVSCADMLAIAAKESIVLAGGPSWMVPNGRRDSLRGFMDLANDNLPGPSSTLKQLKDRFKNVGLDRSSDLVALSGGHTFGKSQCQFIMDRLYNFGETGLPDPTLDKSYLATLRKQCPRNGNQSVLVDFDLRTPTLFDNKYYVNLKENKGLIQSDQELFSSPDAADTLPLVRAYADGQGTFFDAFVKAIIRMSSLSPLTGKQGEIR... | 14 |
Q7UKV0 | 3.1.1.29 | ACT_SITE 19; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MKLVVGLGNPGRKYDQTRHNIGFMVADALVRRYVGSPPTTKFEGEISECRIENEKVLVLCPQTYMNASGQSVRKAMDFYKLSPEDILVICDDLNLETGRVRLRRSGSAGGQKGLVDIIRHLGSEQWARLKIGIGRPPAKWQVSDYVLGKFDKTELEEMEHAIVHSCDATACWVADGVTEAMNRYNAASGT | 127 |
A0A067EXM3 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATKRHHHLCSSYFFLLLPLLLQFYSGESQLQFNYYAESCPKAEDIIKQQVINLYNKHGNTAVSWVRNLFHDCIVKSCDASLLLKKAGGIVSEQASERSFGMRNFRYVDTIKEALEEECPVTVSCADIVALSAREGIVMLGGPRIEMKTGRRDSKESYFTEVDKLIPNHNDSLSTVLSAFQSTGIDVEGTVALLGAHSVGRVHCVNLVHRLYPTVDPSLNPEYGEYLKRRCPTPNPDPKAVLYARNDPETPMIIDNNYYKNLLNQKGLLIVDQQLASDPRTAPFVEKMAADNGYFHQQFSRAVGLLSENNPLTEDQGEIR... | 14 |
A0A9R0K0F9 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALHNLALCLVIVSCFLVVICEGQSSVPVAPGLSYTFYSTSCPNLESIVRIHLLQVLENDTTQAAGLLRLHFHDCFVQGCDASVLLDGSTSGPSEQNAPPNLTLRQAAFKIINDIQTLIQGQCGQVVSCADVTALAARESVLLSGGPYYNIPLGRRDSPNFATTNVTLANLPPPTFNTSQLINLFSSKNLTTTDLVALSGGHTIGIGHCTSFTNRLYPTQDSNMDKTLANNLKLTCPASNTTNTTNLDLRTPNIFDNKYFVDLMNRQGLFTSDQDLYTDSRTKSIVQTFAVNQTLFFQNFIDGMIKMGQLGVLTGSQGQI... | 14 |
Q5ARP5 | 3.2.1.22 | ACT_SITE 485; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9ALJ4"; ACT_SITE 547; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q9ALJ4" | MTNSKARYVLEPVQVTGTTFALNGTTLSYQFHVDEPSADLRSDHFGGSISGPIPVDPEPIVDGWTGMPDRVRREFPDQGRGDFRVPAFRIRQAEGHTVSAFRYREHEIVPGKEVSASGLPGVFGDAHDATTLIVRLVDPYSDLAAELKYTVFPKYDTVVRSASITNKSNSDVTIESLASLSVDFPFDELEMIGLRGDWAREAHRLRRKVDYGVQSFGSTTGFSSHLHNPFVALVHPSTTESQGEAWGFSLIYSGSFTINVEKSSQGLTRVSIGPSQLSWTLKPGETFDSPECVAVYSSTGIGGMSRSLHGLYRKHLMKSK... | 162 |
W5NA62 | 3.2.1.35 | ACT_SITE 141; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MSGARWPLPACGLWLVLLLSPGCCRAGPPKPTRRPFLSGRALLLAWNAPTEDCRPRYSVDLDLGQFEIRASPNEGFVGQNLTIFYKDRLGLYPYFERSGRAVNTGLPQTSSLDAHLQKMPEGVNKYIRDPSARGLAVIDWEEWRPLWIRNWDAKDVYRSVSRNLTARRNPTWSKEEVNKVAQQEFEASARAFMLGTLRHAKHLRPHQLWGFYLFPDCYNHDYKNSLENYTGRCPDVEVSRNDQLAWLWAESTALFPSIYVGSVLRSSPFGRQFVRNRVREGMRLAQVGEGPARPVFVYTRPTYTNEMELLTEMDLVSTIG... | 166 |
A0A0A0LQN2 | 2.7.11.1 | ACT_SITE 313; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 330; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MEAAGMPAVEEKVDEVEPSIMNNDESVEEDEGEEDLSWSSDSEIGDALDWLDAKEDRETVDGTFSLNARRPNAHGGLYSRHNSSTLQPLSNRNQKFTNHIRASPLAEWEGRFNVGMSNSVTTAIRDSVKEMAIGKTKTTEKADRATVEQAIDPRTRMVLFKMLNRGVFHDINGCISTGKEANVYHATKSDGQEFAIKIYKTSVLVFKDRDRYVQGDYRFRHGYCRHNPRKMVKTWAEKEMRNLMRLKAAGIRCPTPLLLRMHVLVMEFIGKTGWAAPRLKDAALSLNRLRESYLEIIITMRTLYQKCKLVHGDLSEYNIL... | 99 |
Q5BFC4 | 3.2.1.23 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000255" | MRLLPVWTAALLAAQAAGVALTHKLNGFTITEHPDAEKRELLQKYVTWDDKSLFINGERIMIFGAEIHPWRLPVPSLWRDILQKVKALGFNCVSFYVDWALLEGKPGEYRAEGSFAWEPFFDAASDLGIYLIARPGPYINAEASGGGFPGWLQRLNGTIRSSDQSYLDATENYVSHIGGLIAKYQITNGGPVILYQPDNEYSGGCCGQEFPNPDYFQYVIDQARRAGIVVPTISNDAWPGGHNAPGTGKGEVDIYGHDNYPLGFDCANPDVWPEGNLPTDYRDLHLEISPSTPYALVEYQVGAFDPWGGPGFEQCAALTG... | 163 |
O30297 | 2.7.1.23 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MRAAVVYKTDGHVKRIEEALKRLEVEVELFNQPSEELENFDFIVSVGGDGTILRILQKLKRCPPIFGINTGRVGLLTHASPENFEVELKKAVEKFEVERFPRVSCSAMPDVLALNEIAVLSRKPAKMIDVALRVDGVEVDRIRCDGFIVATQIGSTGYAFSAGGPVVEPYLECFILIPIAPFRFGWKPYVVSMERKIEVIAEKAIVVADGQKSVDFDGEITIEKSEFPAVFFKNEKRFRNLFGKVRSIG | 89 |
E9H5J0 | 2.7.10.1 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MVRSYADLSALASLVSELKILIHLGSHLNIVNLLGACTDVANGDFLVIVEYCHFGNLLNHLLANRHCYMDQVNENGELAQLDSFQDVSRYFIHSIDNIFIELRTPQGQSTDVECTDDQTNHPFSTRDLTCWAFQIARGMDYLSGRNVIHGDLAARNVLLATNGVVKIADFGLSRKVYQDSNYKKKGEGMLPVKWMAIESLTDRIYSSQSDVWAFGITMWEMFSLGKAPYPEMEDIGGLIQHLEGGGRMEMPRNAPNGVAEIISRCWKADPNVRPTFAQLEHMLGDWVEESIRTNYVEMNEPYSRRNAERFGNLVDEFMSQ... | 97 |
P47711 | 3.1.1.4 | ACT_SITE 67; /evidence="ECO:0000250"; ACT_SITE 112; /evidence="ECO:0000250" | MKLLLLLLVVMASDLPQAHGHLKQFTEMIKLTTGKNGLTSYGAYGCHCGVGGKGTPKDATDRCCVRHDCCYDRLMKRGCGTKFLNYRFTHKGSSITCSVKQNSCQKQLCECDKAAAYCFAANLKSYSRRYQFYYNGLCRGKTPSC | 130 |
P35005 | 3.4.21.4 | ACT_SITE 71; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 116; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 210; /note="Charge relay system"; /evidence="ECO:0000250" | MLKFAVLLSVLACALAGTIPDGLLPQLDGRIVGGYETSIDAHPYQVSLQRYGSHFCGGSIYSHDIVITAAHCLQSIEAKDLKIRVGSTYWRSGGSVHSVRSFRNHEGYNSRTMVNDIAIIRIESDLSFRSSIREIRIADSNPREGATAVVSGWGTTESGGSTIPDHLLAVDLEIIDVSRCRSDEFGYGKKIKDTMLCAYAPHKDACQGDSGGPLVSGDRLVGVVSWGYGCGDVRYPGVYADVAHFHEWIERTAEEV | 177 |
A0A0K9NZW1 | 3.1.1.11 | ACT_SITE 445; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPAFQDFGPWSDRRKAELNQKRKKNFIIFGSIALILIISFSIAVVFIIMNMTQKKCSRPVTSTNSSTSSDAAGKALPSTTSIKTVCSKTDYRYLCEKVLKESVGDSKNKSSDPKALIGFSIDAISSELEKVQNKSKLIKSTDPLVSGAVDDCDELFVYAMEDLQRAKQTVDEKDLNQLQNQTHELKNWLSAVVSDQMTCVEGFPQGESKERMRKEVETSRKHTSNALAIVDQMVSLISSFEINDLGFQHRLTEQSSESIENDQLIVTDTGDILPSWVPEEDRRILKERKEKEIEPNVVVAQDGSGKFKTITEALAAMPTI... | 125 |
A9V2V6 | 3.4.19.12 | ACT_SITE 85; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 159; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MAGRWCLMESDPGVFTDLIEGVGVKGVQVEELWALDVDALKQLAPVYGLVFLFKFTPEAHKSETQPIDYKIPGLFFAHQVINNACATQAILSILLNAPDIELGEHLTGFKSFANELDPETAGLAISNSEELRTVHNSFSRQETFTMEEKVADKDDDVYHFIAYVPHGGRLYELDGLQRGPIDHGPVGEEWVETVVPVLQKRIERYTSTEIRFNLMAVCRDRREALEEEKENAESMALSLPEASPEAAEWQAKAAEFEAQLQQEHAKRQNWKDENRRRKHNYIPFILELMRSLAREKRLQPLVAEAKRKAVERLDQQKRTG... | 175 |
H9GFI4 | 2.3.1.286 | ACT_SITE 198; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MESREDPGAAATSSASNEADAAAEREAASGSSGSDSDDEGGASGLTEMEFLRNLLSRTLNLGSEKPEKVLDELTLEGVSRYMLTEKCKNVVFMVGAGISTAAGIPDFRSPGTGLYANLQQYNLPYPEAIFEINYFKKHPEPFFALARELYPGQFKPTVCHYFMRLLKEKGLLLRCYTQNIDTLERVAGLDHEDLVEAHGTFFTSHCISPTCKKMYSLEWMKEKIFSSLIPKCEKCQSVVKPDIVFFGENLPSRFFSLMQSDFQNVDLLIIMGTSLQVQPFASLVARVPTNTPRLLINKEKTGESDPFMSLMGFGCGMDFD... | 58 |
Q7Q7C8 | 3.2.1.52 | ACT_SITE 374; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MAEVQYLVTALFALFVCTGIGVHSEGEAVWGYQCKNDRCVKTAISEESYPAANAISLPACRLFCGEGAGLLWPQPTGQLAVENELAHIDPDQVWFQWDEKLTQLVGLWEANRDRFRSQLKKRAQGAALKPGGKAVRIKLNVTDDSLALNYETDESYSLTVVAGSSKDELQATIEAKTFFGARHGLETLSQLVLYDDIRNELQMVARARVSDAPAFPHRGLALDTSRNFIDLESLRRTLDGMAMVKLNVFHWHITDSQSFPLVVKSRPTLHTYGAYSRRDVYTADDVQRLVQYALERGIRIVPELDAPAHVGEGWEKLGVT... | 170 |
A0A1D8PJ89 | 3.1.3.16 | ACT_SITE 345; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MSSPKEALEWKDKGNNLLKQHKYDEAIEAYTKAIEIDPNNAIFYSNRAQVQIKLENYGLAIQDCDLAIKLDINFLKAYYRKGVSLMAILNHKQALENFKFILKKLPNDKLTLENYKQCTNYLKRQAFEKAIAGNDDNESIFNKIDYQSIQIEKSWSGPELNITTTTTNTTTTNTTTTTTVGDNNKNKKSDVIVNIEGLDHDYLKYMIKLFKNGGKLPKRHVFAIIAKVYEILKQENTMTEISLLHSQIDFNNDNDDTINNPHGKGKGKGDQIIGGKKLTVVGDTHGQFFDLLNLFDKFGHVTQDHIYLFNGDFVDRGSWS... | 144 |
A0A8I3Q499 | 2.3.1.286 | ACT_SITE 179; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MDMGAASLWGVRKAPCAVELAVLNSGITGGRRPISFSTRTSSIFGSGGDHKKKLFLQDIAELIRARACQRMLVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAVFELAFFSHNPKPFFTLAKELYLKNYRPNIIHYFLRLLHDKGLLLRLYTQNIDGLERVAGIPASKLVEAHGSFASATCTVCRRPSSGKDIWADVSMDKIPRCPVCTGVLKPDIVFFGETLPQRFLLHVLDFPMADLLLILGTSLEVEPFASLSEAVRSSVPRLLINRDVVGPFAWCPRSRDVVQLGDVVHSVERLVELLGWREELQDLIQQ... | 58 |
O25116 | 6.3.4.2 | ACT_SITE 378; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 513; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 515; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MDRAKFIFVTGGVLSSLGKGISSSSIATLLQHCNYQVSILKIDPYINIDPGTMSPLEHGEVFVTSDGAETDLDIGHYERFLNRNLTRLNNFTTGQIFSSVIENERKGEYLGKTIQIVPHVTDEIKRRIKSAAKGLDFLIVEVGGTVGDMEGMFYLEAIRQLKLELGNEKVINVHVTLIPYIQTTNELKTKPTQHSVQELRRLGVTPQIILARSPKPLDKELKNKIALSCDVEQDSVIVATDTKSIYACPILFLQEGILTPIARRFNLNKLHPKMAAWNTLVEKIIAPKHKVKIGFVGKYLSLKESYKSLIEALIHAGAHL... | 252 |
U5CVE0 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASDHVLIVLITFFLLLNLSSGALTVQFYRHSCPQTETIVRTIVTQHFTSDPSIPAGLLRLHFHDCFIRGCDASVLIDSRGGHAAEKEAPPNLTLRGFEIIDEIKSELEKQCKGIVSCADILALATRDGVALAGGNFYALPTGRRDGTISNIEDVHLPGPSFSVDAALTAFTSINMDLSDLTTLLGAHSIGFCHCGFFNERLYNFMGTGFPDSTMDFSVAQSLRSTCPQPLQQITNTSADPRIFMDQSTNSPFSLDNSFYHGVLSGRSVLQLDQELAYTDVTSTMALNFSRNKTLFLQRFSKAMIKLGNVGVLTGLQGEI... | 14 |
H3GWW6 | 2.3.2.26 | ACT_SITE 506; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MADVIVVLIVASQVALYLIVAYIFRKLQRKYRERSYSELQQALIARDDATGEHRIDVATLEISGKKPSYRSTSAGKYPGYVAVFKEGGGKDGREMETEVDVIPDGEPGSVTRKLEHETKLMKIQTVAADEADALAFATGPPSSRNVDVKGLLNLSREDFPTKFAHFVACTSTLIVPPQLEVLKLFLRREHVVEESMEYLCCMDDNDTHSVVRIDFAAETAVDAGGVHREWFALVTELVIDPSLGVFTCTNHAAQTYFFNVNSRQAIGEEHLAYFFAVGRLVGRALLEGEVVGFHFAPALLKLILGIPFTFRDYGDLDPVT... | 65 |
Q7UJI0 | 3.5.4.5 | ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MAESAPHFGESTSLSLYPAMTDVHSHASEIDPPSDEDVQRLIQAAISARDHAYAPHSHFYVGAALLTHDGRIVEGCNVENASYSLTQCAERTAVCTAVAGGYRMFHAVAIASIGGAMPCGACRQVLAEFGSDLYVYTIDVIDGDQQMRRLSELLPDAFSTSDIPKR | 187 |
A0A072UIQ7 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKMGNQSYFKVLIICLIAIIGSTHAQLQPGFYAKSCPKAEQIVLKYVHDHIPNAPSLAAALIRLHFHDCFVKGCDASVLLNSTQTNQAEKDAIPNLTLRGYEFIDTIKSLVEKECPGVVSCADILTLTARDSIHAIGGPYWKVPTGRRDGIISKAADTFTSLPAPFHNLTVLLTLFGNVGLDANDLVLLSGAHTIGVSHCSTISTRLYNFTGKGDQDPDLDNEYAKNLKTFKCKNINDQTTLIEMDPGSRNTFDLGYFKQVVKRRGLFQSDAALLKSSTTRSILAQHLQSNEKFFTEFGRSMEKMGRINVKIGTEGEIRK... | 14 |
A0A061DSC1 | 3.1.1.11 | ACT_SITE 208; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVESLHFPLCKELEVKMQFLQHILALIFIVLLYFSISKALECQLNNANKFKVAHTIRVDQSGKGDFKTIQNAIDSIPSNNDKWIRILISPGHFREKVTIPANKPCIFLEGAGSKLTSIEWGDHMDTCDSATFTSSPDNIVAKGISFKNIYNIPSGPDAKKKVEPALAVRIYGDKSAFYNCAFFGLQDTLWDVQGRHYFYNCYIEGAVDFIFGSGQSIYEKCEINLTAGKYAPEYPNGYITAQGRNSSDDPSGFVFKYCVFTGYGKTYLGRAYGAYSRVIIYKSVLSDAILASGWDAWRYVHHEGNLIYVEADCKGPGANT... | 125 |
Q8Y691 | 3.1.26.3 | ACT_SITE 50; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 122; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MNQWEELQESVGFDFKNVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSDYLFNKYPDMAEGHMTKMRAAIVCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADVFESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDYKTQLQEIVQRDRDVLIEYDILGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINKLIHR | 138 |
Q9XIP2 | 3.4.19.12 | ACT_SITE 224; /evidence="ECO:0000255"; ACT_SITE 227; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96G74"; ACT_SITE 332; /evidence="ECO:0000250|UniProtKB:Q96G74" | MTRILVQRGSSGSSSNSSRPSSSSSSSSGSETQINNNIPVPPVTIDEEITDEKQEEVTVVEKAECSDAKDVAVDSDEPADREDDEGLVVAENVHVQSEGIDCDSPVSGGSNSDSPPVPAPPPKPSSTVNPGSNRSVLGSFGALRIGPTRRAAGPRSLVSSRSSPTGSHPSSPRSHSENEGYNSSDEHMPCYVPSHPGSGLEREHQFEAEIRYSKGFEIRRMLEDGNCLFRAVADQVYGDSEAYDLARQMCMDYMEQERDHFSQFITEGFTSYLKRKRRDKVYGNNVEIQALAEMYNRPIHIYSYSTEPINIFQGNYSTDT... | 175 |
O32179 | 1.5.5.2 | ACT_SITE 129; /evidence="ECO:0000250|UniProtKB:Q72IB8"; ACT_SITE 179; /evidence="ECO:0000250|UniProtKB:Q72IB8" | MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTVKRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLDLSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAYLYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTAVATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTDWFSYFMRRIAERPANAAFVLKGILKK | 30 |
A0A9R0IT30 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | NQLGAQTNVIAFLFLFFSSPLTLALQVGFYSKTCPNAETIVQQVVQQRFAADKSVAAALLRMHFHDCFVRGCDASILIDSTSTNQAEKASGANGSVREFALIDQIKAKLEQSCPQTVSCADIITLATRDSVALVGGPKYNVPTGRRDGLISKSNEVNVPGPSSTVSQAQQSFKIKGLTINDMVVLLGGHTVGITHCSFISDRLTNFQGTGAPDPTMNKTLLTQLKGTCGANPSADPSIFLDQKTPFVFDNEYYNQLKSNNGVLQIDQELAVDPLSSTLVNNMAANNAGFVQNFAKAMVKMGGIQVLQGTAGEIRTNCRVF... | 14 |
A0A0Q3GEV8 | 2.7.1.11 | ACT_SITE 289; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MASHIILPKEEEEEEGLGVAVEADHDSPEPPRYQAEPVPKALPFSATCVRISRDSYPNLRALRNASAVSLRDDDADFVKLEEGDYGYVLDDVQHLTDYLPELPTFPNPLQDHPAYSTVKQYFVNADDTVPEKVVVQKNSPRGVHFRRAGPRQRVYFEPEDVKACIVTCGGLCPGLNTVIRELVCGLSHMYNVNDVFGIQNGYKGFYSSNYLPMTPKSVNDIHKRGGTVLGTSRGGHDTRKIVDNIQDRGINQVYIIGGDGTQKGAYEIFKEIRRRGLKVAVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAIDAAHVEAS... | 84 |
B4FCJ7 | 3.1.1.11 | ACT_SITE 190; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPAGRSAPARGAAVAAMLLLTMLARLPCLEAQSSRRPTVLTVDMTGKGDYRTIQEAIDAIPAAANNSTSAAIVTINVNPGIYTEKVVVNKAGVSLVGRSATSTIVTWSGPWNQNHQSEFALYVQATDFVAKGLTFQNTLGSKDNGPAVAAKVDADKAAFYDCRFLSYQDTLLDATGRHYYRGCYIEGATDFIFGTGKAFFESCHLHSTSDAKGAFTAQRRSTESENAGFSFFRCESTGTGVATAILGRPWGPYARVVFALCNMSNTVAPEGWNNWDNTANEKTAFFGQFQCYGQGSGTQGRVTWAHNNLSPNEAAPFLTN... | 125 |
A0A0A0LPP5 | 2.3.2.26 | ACT_SITE 1827; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAEASSAAPSSSSSGPNTRSTKRSRLSATSSSNLAAASTLSISTRSRSTRTQEPSATTTPMDSTNESSGSRRRGKNSDKENSDKGKEKEHEVRIGDRERNADQSFGLNIEGSGGGEDDDNDSEGGIGVLQQNLSTASSALQGLLRKLGAGLDDLLPSSAIASASSSQQRGRLKKILSGLRADGEEGKQVEALTQLCEMLSIGTEESLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVPCFCARLLTIEYMDLAEQSLQALKKISQEHPTACLRAGALMAVLSYLDFFSTGV... | 65 |
A0A3B3IH53 | 2.7.10.1 | ACT_SITE 744; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MELMMYKCLILLACVCHWVGVVSAEEEVLMNTKTETSDLKWTIFSRSKPEWEEISGLDEEGISVRTYQICQTDSSSSHWLRSGFIQRQGASQVYVELRFTMMECSSRGTHHRSCKETFNLYYYQADSNEATATYPPWMENPYTKVDTVAADFLLRKGGERKFNVKTLRLGPLSKRGFYLAFQAQGACMALLSVRVFFKKCPPLVSALSSFPETVPRTLVQEAQGECVKNAAQQGPRPRPPKLFCGEDGQWVGQPTTSCACLPGYEPTEGQTLCTACPVGQFKSSTEGQCQSCPGFSHATSRGASVCACRPGFLRAQSDPP... | 97 |
M3VZG7 | 3.1.3.48 | ACT_SITE 1101; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1" | MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYHNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRRLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRPPVIFRWHDIAHMSHNKSFFALELASKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQTVTVNP... | 149 |
Q33AZ5 | 5.1.3.3 | ACT_SITE 196; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MRCLIASSSRDKTESDFSESRQVRLAVAAMAAEEILELSNGRITAKIAAWGATITSLIVPDAHGNLADVVLGFDTLEPYMKGISPYFGCIVGRVANRIKEGKFTLNGVEYSLAINNGPNSLHGGLKGFDKVVWDVVERKSECPSITFQYHSKDGEEGYPGDVTVRATYSLPDSTTLRLDMEAVAENKATPINLAQHTYWNLAGHNSGDTLDHSIQIWGKHITPVDENTIPTGEIMPVKGTPFDFTTEHKIGARINDVPGGYDHNYVLDSGEEKNGLKHAAKLKDSSNSRTLDLWTDAPGMQFYTANYVDGVTGKGGAVYG... | 211 |
M4FBQ3 | 2.7.1.11 | ACT_SITE 311; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | METLSPPIITSTLSIPYSNSSVLRRSHGLSSLILRKQRSPAANLSLISSRSSFARASAVEHGKSSASIDLSDPNWKRKYEREFEERFSIPHITDVFPDAEAIRSTFCLKMRSPTEEFVGGYPSDEEWHGYINNNDRVLLKVIRYSSPTSAGAECIDSDCSWVEQWIHRAGPREKIYFRPEQVKAAIITCGGLCPGLNDVIRHIVITLEIYGVKNIVGIPFGYKGFSDKDLTEMPLSRKVVQNIHLSGGSLLGVSRGGPSVSEIVDSMEERGINMLFVLGGNGTHAGANAIHNECRKRKMKVAVVGVPKTIDNDILHMDKT... | 84 |
D8T3T3 | 2.3.2.26 | ACT_SITE 651; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MEDASTTSSSSSKENVRLDVMKYFDEFRERGMLANEAAALALKVAYGNVDPPLDPASLLDAIAKAGETRQYRELIETIKFAFSSVDVVSTCFLSKTPPNSDSSSSLVAGMELSLLEDFYVSALRLEAPEVNLAIMEANEQLLASLLRSLKDGSWPSGSLRAVIIMLENRLFMEPDYYGTLSRLWRLVLDAPQSFRASLFSALKEYDGKQLERLVVVIQQFITIQLYEFQQVNTMVVSGVEILGFIYSVNESSLRIGHSAFYNDAVNNDDFNLKDDFSRWVDPTRQQFSFCQYPFVFDPSSKSKILQMDSIFQMTEEFEDA... | 65 |
A0A1U8G949 | 3.1.1.11 | ACT_SITE 374; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSTHKFNSLLLMFCSLSLFLHQSLSNTDDQETNDHDINWWCSKTPHPDPCIHFMSRDANSSIPKNKSEFRTMTVQVAMDHVIQVQNHAKNVSQHCRGKRKRLVWMDCEKLMDDTILQLNRSLDGIKSNSNSFSDFDAQTWLSASLTNIETCLSGSNDLNVSNILQPNLSTNVSQLISNCLAVNGEFLEAENTTQVGGFPNWLTTSERKLLQTSSIDLMATRANYVVAKDKSGRFRSIQTAINYAASTRVGNQRIVIYIKRGVYKENIVIGPTMGKFMLVGDGLRNTIIIGSRSVAAGFTTYSTATVGVDGIGFIARGITF... | 125 |
Q9NI63 | 2.7.11.1 | ACT_SITE 224; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEKHHRLPLPELHDDKHRHKQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKI... | 99 |
Q47474 | 3.1.1.11 | ACT_SITE 259; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 292; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MSLTHYSGLAAAVSMSLILTACGGQTPNSARFQPVFPGTVSRPVLSAQEAGRFTPQHYFAHGGEYAKPVADGWTPTPIDTSRVTAAYVVGPRAGVAGATHTSIQQAVNAALRQHPGQTRVYIKLLPGTYTGTVYVPEGAPPLTLFGAGDRPEQVVVSLALDSMMSPADYRARVNPHGQYQPADPAWYMYNACATKAGATINTTCSAVMWSQSNDFQLKNLTVVNALLDTVDSGTHQAVALRTDGDRVQLENVRLLSRQDTFFVNTSDRQNSYVTDHYSRAYIKDSYIEGDVDYVFGRATAVFDRVRFHTVSSRGSKEAYV... | 125 |
Q8WPJ2 | 3.2.1.78 | ACT_SITE 177; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P07985"; ACT_SITE 308; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P07985" | MLLTALAVLFASTGCQARLSVSGTNLNYNGHHIFLSGANQAWVNYARDFGHNQYSKGKSTFESTLSDIQSHGGNSVRVWLHIEGESTPEFDNNGYVTGIDNTLISDMRAYLHAAQRHNILIFFTLWNGAVKQSTHYRLNGLMVDTRKLQSYIDHALKPMANALKNEKALGGWDIMNEPEGEIKPGESSSEPCFDTRHLSGSGAGWAGHLYSAQEIGRFVNWQAAAIKEVDPGAMVTVGSWNMKADTDAMGFHNLYSDHCLVKAGGKQSGTLSFYQVHTYDWQNHFGNESPFKHSFSNFRLKKPMVIGEFNQEHGAGMSSE... | 172 |
A0A8J1MGE9 | 2.7.10.1 | ACT_SITE 1203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000617-1" | MVHAKMLVAVPVALLFLSLLPQCMGQCEEAAKMAEMDLNLKLNLQNFTTDTPIQNIIMFKGYVYVGAVNKIYVLNENLTKISEYKTGPLLKHSDCLPCKNCTDNLLSPNGTWKDSVNMALFVEDFYDDQLISCGNIRKGECQRHTLHSDKPWDIASDVHCLYSSQMVEDKDSCPDCIVSTAGSKILVTVGDRFVKFFVGSTLTGQPSTIHSVSVRRLKETQDGFEYLTDQSYIDVLPHLRDIYPIRYIYTFESNNFVYFLTVQRESLDSQAYHTRIVRICSSDSELRSYIEMPLECIFTEKRRKRSTASAVFNIVQAAYL... | 97 |
Q09444 | 3.4.19.12 | ACT_SITE 83; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"; ACT_SITE 158; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393" | MTDAGSWCLIESDPGVFTEMLRGFGVDGLQVEELYSLDDDKAMTRPTYGLIFLFKWRQGDETTGIPSDKQNIFFAHQTIQNACATQALINLLMNVEDTDVKLGNILNQYKEFAIDLDPNTRGHCLSNSEEIRTVHNSFSRQTLFELDIKGGESEDNYHFVTYVPIGNKVYELDGLRELPLEVAEFQKEQDWIEAIKPVIQQRMQKYSEGEITFNLMALVPNRKQKLQEMMENLIQANENNELEEQIADLNKAIADEDYKMEMYRKENNRRRHNYTPFVIELMKILAKEGKLVGLVDNAYQAAKEKSKLNTDITKLELKRK... | 175 |
A0A2K2BYN9 | 3.1.1.11 | ACT_SITE 425; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MIQEDHGSLTEISDSGKHISFSQKNKSLSLALFVSLLLVATIAAVVTPVNSQNSNKNDAAHSIIKMSCSSTRYPELCYSAIANGPGAAASLAAINDENDVLIESIRATQQAIDTNTAGIESYKTTNKMKLTNQQNDALDTSTDNNELSQSDLQNAINSLNYYTNEIPLSDQDTEPDINTPLSSCITYQDTIMDGFSHTAADKQVRKDISDGVDNVRKMCMNTLAMNMNMTATRIANELKTTKRNLKEENSRNESGWPKWLSVANRRLLQSSSLTPDVVVAADGSGNYSTVSAAVAAAPTRSSKRYVIRIKAGVYRETVQV... | 125 |
A0A251R7K6 | 3.2.2.27 | ACT_SITE 215; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MRLVVSFSLGVCHFPAHPKSTIIRPLAPINRKAYFYDRMSAVPMALEKERPRKEEMGSKNKNKTLLDLFQPTASSAKRLKTDSIRATHSDSVSPVPPPSHDDSSSSDLTAQQKSRMEFQKLLAKARRNLSICSNRLSNSNSKGEGVKLEELLVEETWLEAFPSELQKPYAKTLSKFVENEICGGALPIYPPTHLIFNALNSTPFDRVKAVILGQDPYHGPGQAMGLSFSVPEGVKVPSSLVNIFKELHQDLGCSIPSHGNLEKWAVQGVLLLNAVLTVRNHQANSHAKKGWEQFTDAVIKTISQKREGVVFLLWGNSAQQ... | 173 |
A0A0R0J590 | 3.1.1.11 | ACT_SITE 404; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSEGNAGKGKKIAIIGVSTLLLVAMVVAVTIGVNLNENGSNNDIEDNKKDHVASSIKAVQTLCHPTNYEKECEESLIAGAGNTTDPKELIKIFFNITITKIGDKLKETNILHEIEEEPRAKMALDTCKQLMDLSIGELTRSLDGINEFNLINVDKILMNLKVWLSGAVTYQDTCLDGFENTTSDAGKKMKDLLTIGMHMSSNALAIVTGLADTVNDWNITKSFGRRLLQDSELPSWVDQHRLLNENASPFKRKPNVTVAIDDSGDFKSINEALKQVPEKNRKPFVIYIKEGVYQEYVEVTKKMTHVVFIGEGGKKTRISG... | 125 |
A0A1U8B8A8 | 3.2.2.27 | ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166" | MIMSSSKTLMELFQPAKRLKVCETPASKNTISSICHSTTGDHNIADRTGTDSPSTLTVEQKTRIEFNKSLAKSKRNLRICTERVSKSKAEGVDYVKLEDLLVEQTWLEALPGELQKPYAKSLCKFVEREMHGSVPIYPPPHLIFNALNTTPFDRVKAVIIGQDPYHGPGQAMGLSFSVPEGIKVPSSLVNIFKELQKDLGCSVPSHGNLERWAVQGVLLLNTVLTVRKHQVNSHAKKGWEPFTDAVIRTISEKKSGVVFLLWGNSAQEKSKLIDQSKHHILKAAHPSGLSANRGFFGCRHFSQTNQILEKLGILPIDWQL | 173 |
B9HY10 | 3.2.2.27 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MAASSKTIMDFLQPAKRLKLSSSSPSPIDPLNLLNKSLSAKSTSTDLTPDQVSRIELNKLRAKSKRNLKLCSQLVSNSKGSSGHVNLEELLVENTWREVLPGELEKPYFKNLCKFVESEISNGSVAIYPPQHLIFNALNSTPFNTLKAVIIGQDPYHGPGQAMGLSFSVPQGVKAPSSLVNIFKELKQDLGCSIPSHGNLEKWAIQGVLLLNTVLTVRNHQANSHSKKGWEHFTDAVIKTISQKKEGVVFLLWGNSAQEKSKLIDQTKHHILKAAHPSGLSANRGFFGCRHFSRTNKLLAQMGISPIEWQL | 173 |
Q09092 | 2.7.11.1 | ACT_SITE 653; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKGARNIYHHSYMSFLLVFVVMILIHPALSIYINTLSSTESLTISSNKTLVSPGSIFEVGFFRTNSRWYLGMWYKKVSDRTYVWVANRDNPLSNAIGTLKISGNNLVLLDHSNKPVWWTNLTRGNERSPVVAELLANGNFVMRDSSNNDASEYLWQSFDYPTDTLLPEMKLGYNLKTGLNRFLTSWRSSDDPSSGNFSYKLETQSLPEFYLSRENFPMHRSGPWNGIRFSGIPEDQKLSYMVYNFIENNEEVAYTFRMTNNSFYSRLTLISEGYFQRLTWYPSIRIWNRFWSSPVDPQCDTYIMCGPYAYCDVNTSPVCN... | 99 |
P51569 | 3.2.1.22 | ACT_SITE 170; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 231; /note="Proton donor"; /evidence="ECO:0000250" | MKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRFPSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGSFGSYDIDAQTFADWGVDLLKFDGCHCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNKDVIAIN... | 162 |
O48780 | 2.3.1.199 | ACT_SITE 236; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 315; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 399; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 403; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 436; /evidence="ECO:0000250|UniProtKB:Q38860" | MDVEQKKPLIESSDRNLPDFKKSVKLKYVKLGYHYLITHGMYLFLSPLVLVIAAQISTFSVTDLRSLWEHLQYNLISVVVCSMLLVFLMTIYFMTRPRPVYLVNFSCFKPDESRKCTKKIFMDRSKLTGSFTEENLEFQRKILQRSGLGESTYLPEAVLNVPPNPCMKEARKEAETVMFGAIDELLAKTNVNPKDIGILIVNCSLFNPTPSLSAMVVNHYKLRGNILSYNLGGMGCSAGLISIDLAKHLLHSIPNTYAMVISMENITLNWYFGNDRSKLVSNCLFRMGGAAILLSNKRWDRRRSKYELVDTVRTHKGADD... | 56 |
H3G8Q0 | 3.4.19.12 | ACT_SITE 84; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 159; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSWCTIESDPGVFTALIEDIGVQGVQVEELYSLDEQQFAALSPVYGLVFLFKYEAKHGEEADPPVFASEEDGLFFAKQVISNACATQAILSILLNCQGLELGETLTEFKAFTSDFPSEFKGLAISNSDKIRLAHNSFARAEPFVVEERKAATEDDDVYHFVAYVPVNGKVYELDGLRDGPICLGGVPEGDNREAWLQVACPVIQKRIEKYAASEIRFNLLALVRNRIQAFEEQLGALIEAGGSEELAAQIQADLAAEQQKRNDWALENRRRKHNYIPFIVQLLKTLAEKKQLEPLTKQQLDARKAAAANTKKPTNAQ | 175 |
A0A251V3P4 | 3.1.1.11 | ACT_SITE 433; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFQDFDQISERRRLERKQRLKQKIIIGVVVAILLLSGAVAAFLIFLNSSQTDDPNDGADNVEPTSGNDKNKDNSSGASKDKGIDGQKVLQTQKAVKTICQTTDYKETCESRLEKSLSSKLSGLPGPDDFVKAAVSAASDELNNAITQTSKLMKVETAPEKQKATFDVCKQVLEGAQSDFNHSQNAAGSPDLGTWLSAVITYQQTCIDAVTEDATKTSIEQALKTTKELTSNSLAIFSSVQKVAPPPAAASHRRLLTDRPDLPSWMTLETRRLLKADAPSLAPNVTVAKDGSGDFATISKALEALPDSYQGRYVIYVKKG... | 125 |
K3XPJ9 | 3.5.1.98 | ACT_SITE 119; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MTHHLINAYGLPDDMDLLRVAPATEEDLKVAHSEEYLDLLCHLMPAIYENAAATQKAAQQHGLGEVRDRRTGCSTNDNPVIDDIWDYCLCYAGGSLAAARALASGRYRVAINWSGGMHHACEGKASGFCYVTDAVVAIKVLLGRFGRVLYVDIDAHHGDGVESAFLEQSRVMTVSFHQYDGRGFFPGTGGALYRALNVPLEAGTGDDEYHRLFGPIMERVMQVFRPDAVVLQCGTDSLAGDRITGLQLSVRGHAKCVHLIRSYDVPLLLLGGGGYTINHVASCWCYETAVAIGKEIPDDIPQYGFQRYYKSQGYKLHYYH... | 184 |
Q96LW2 | 2.7.11.1 | ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGAVSCRQGQHTQQGEHTRVAVPHKQGGNIRGPWARGWKSLWTGLGTIRSDLEELWELRGHHYLHQESLKPAPVLVEKPLPEWPVPQFINLFLPEFPIRPIRGQQQLKILGLVAKGSFGTVLKVLDCTQKAVFAVKVVPKVKVLQRDTVRQCKEEVSIQRQINHPFVHSLGDSWQGKRHLFIMCSYCSTDLYSLWSAVGCFPEASIRLFAAELVLVLCYLHDLGIMHRDVKVENILLDERGHLKLTDFGLSRHVPQGAQAYTICGTLQYMAPEVLSGGPYNHAADWWSLGVLLFSLATGKFPVAAERDHVAMLASVTHSD... | 99 |
M4FAJ8 | 1.1.1.37 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MFRSMLVRSSSSAKQSLIRRNLSSGSVPERKVAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSEPGMTRDDLFNINAGIVKNLCSAIAKYCPHALVNMISNPVNSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRAKTFYAGKANVPVAEVNVPVIGGHAGVTILPLFSQATPQANLSGDVLTALTKRTQDGGTEVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPDVVECSYVQSTITELPFFASKVRLGKNGVEEVLDLGPLSDFEKEGLEALKPELKSSIEKGVKFANQ | 5 |
Q5A649 | 2.7.11.1 | ACT_SITE 204; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MIPQSNPTAQRRSGDAQNTNNVAPNSVATTTDTALTASTQSGSSSNNANKKLEYIGVYKIGPEIGKGSFATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQILKSMKHPHIVGLLDYKQTTSYFHLVMDYCSMGDLSYFIRRRNNLVKSHPVISSLLHCYPSPEGSHGLNEVLVLHFLRQLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKQEFIDGEFVGMWELPILKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFKAGNHIELLKNIEKANDKIKFPSA... | 99 |
A0A1U8KIW1 | 2.3.2.26 | ACT_SITE 1006; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFFTGDPSSRKRVDLGGRSSKERDRQKLLEQTRLERNRRLWLRRQNSAALTIQKYFRGRKVVEAEHAKVREHFYQTYGKHCQNVDRHCFGPDSDFLRQLIFFFDAHNLNDFSVLVETCRLIQNFVRDSGDTVGLFAGMDYSPNHSLVAYRLKLLSFACIQAIHQNRNQLKDQLLMAPEEATASTTILLQTLLLFLDPKLPWACKAVGYLMQRNVFSLFREVILMVKLNFVVKENISAGGSFGKISTLERVLALMISHVGQSTCVCSNVDSQWSFSSQILTIPFIWQLFPYLKVVFASWRLTLHYTNKMVLCVQNHANLLP... | 65 |
Q10KY3 | 2.7.11.17 | ACT_SITE 275; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGLCHGKSAAVLEPTVEEEEEGATRVAEAAAAPAKPASPAPSAAAAAAAPAKPGTPKQHKFPFYLPSPLPASSYKGSPANSSVASTPARGGFKRPFPPPSPAKHIRALLARRHGSVKPNEASIPESGEPGVALDKGFGFSRHFAAKYELGREVGRGHFGYTCAATCKKGELKGDDVAVKVIPKAKMTTAIAIEDVRREVRILSSLAGHSNLVQFYDAYEDEENVYIVMELCKGGELLDRILARGGKYSEEDAKVVMRQILSVASFCHLQGVVHRDLKPENFLFSSKDENSAMKVIDFGLSDFVKPDERLNDIVGSAYYVA... | 101 |
A9S3T7 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARILRASCIFALVCVIAISLSVNQVDALDYNYYRKSCPQAESIIFREVQRYFKKDPTVAPGLLRLIFHDCFVRGCDASVLLSGRRSERASAINARLHGFQVIDAAKHYLEDACPRTVSCADILAYASRDAVVLTGGKGWRVIAGRRDGRISNKIEPEQNIPTAFASVNELVSTFAQQGLNTEDMVVLSGAHTIGVTHCNHISDRIYNPVDKTMPKDLLKSLQKSCPKASSPTSLVMDRKSVHKFDTEYFRNIRAGYGLMTSDQGLYREDFTRPIVDANLNQRAFVNRFAEAMFKLQFIQPLEAPDGEIRRRCQCRN | 14 |
Q54Q71 | 1.17.4.1 | ACT_SITE 446; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 448; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 450; /note="Proton acceptor"; /evidence="ECO:0000250" | MISNSINVTPNKESKMYVVKRDGTKENVSFDKITSRISFLCEMEPKLNSDIVDPIEVAQKVVSGVFPGVKTTELDNLAAETAAYMSTRHPDYGILAARISVSNLHKQTSKSFVETVKKQYEFINPKSNLLAPLVSKELYEIVMKHGERLESVIDYYRDFDYDFFGFKTLERSYLHRINGKIVERPQHMLMRVSIGIHGEDLESAINTYKRLSEKLFTHATPTLFNAGTPSPQMSSCFLVQMKEDSIDGIYDTLKQCALISKSAGGIGIAVHKIRAAQSYIRGTNGTSNGLVPMLRVFNDTARYVDQGGGKRKGAFAVYLE... | 21 |
A9A4A1 | 3.4.25.1 | ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MSMYMPGATAVGITFDGGVVFASEKRIAFGNFLVSKTTKKTFPITPKVGATCAGLVADMQILSLQIAALAKIRKMELKRDVPPNTVAKMMSNMMYERRYFPLLTQVIVGGVVDKPIMYTLDPLGSVLPDEYAAVGTGAEMALGVLDPQFKPNMTKDEAIDLAKRAVRAASLRDSASGDGVDVLVITKDGTEEFTEEIK | 180 |
Q4WWQ3 | 2.3.1.181 | ACT_SITE 242; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MKLAHLHFPDITSFTRVAHLQQILTNRLLAYKRLSSPATANTGAIQPSGVNSPPPDPTIITFTPNPVYTTGRRDLPPSNTAPFSPSAPLSLPPSLEPIRSILTAPPNGSPRAEYHPTLRGGQTTYHGPGQMVAYTILDLRRLGLTPRCHIRLLENSVIDVLRGYGIQGFVTEDPGVWVRPRPATNTAAAMAVSAGGDGDADGVLPKKITAVGVHLRRNISSYGIGFNVTEEPMWYFQQIVPCGLEGREATSLEGEGVPGVSTGEVADKFVDAFVQRVNADFACGGRATGEKIEGVYNVREEDLLQQ | 55 |
A2F0F6 | 1.8.1.4 | ACT_SITE 450; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MLNSVSRAFTQNPDLLVIGGGPGGYAAAIRAAKLGLKTVCVEKEKLMGGTCLREGCIPSKFFLNMSHKVYEANHEFKNFGIKLPGEAAVDMAIAQRRKNGILAGLSAGIEGLIDRAGGELVHGTATINSKNDVSVKLEDGKTVIFNPKNLLLATGTDKWFPKTFPVDEQIIATSQGVLNWKEIPKTLTVVGGGIIGLELGSVFHSLGSKVTIVDMAPTIGGPSVDPMIGRYVQNILKRRGMDFILGKGVDSCTKTENGVEVVVGDKKLQSERALIAIGRRLHLDGFGLERLNLKRQKNGLIEVNNRLETSEKNVYAIGDI... | 36 |
P48591 | 1.17.4.1 | ACT_SITE 438; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 440; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 442; /note="Proton acceptor"; /evidence="ECO:0000250" | MLKNKSMKTSKLYVIKRDGRQEEVHFDKITSRIQKLCYNLNMDFVDPVTITLQVINGLYCGVTTQELDNLAAEIAAGLTCNHPDYAILAARIAVSNLHKETKKAFSDVFEDLYNHVNKETNQKVPLVSEFHYNVVKKNATRLNSSIIYDRDFGYNYFGFKTLERSYLLKRNGKIAERPQHMLMRVAIGIHGEDIDAAVETYNLLSERYFTHASPTLFAAATNRPQLSSCFLLTMTADSIEGIFKSVEQCAMISKSAGGIGLNVHCIRAKGTSICGTNGTSNGLVPMLRVFNNVARYVDQGGGKRPGAFAIYLEPWHSDVF... | 21 |
G1KB08 | 3.1.4.11 | ACT_SITE 205; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 250; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | RTACRDLQFARIKDSTFQFYSFLLSGGRHKDVGLCKLPSLFSLNPSDKDKDGRMNFKEVQALLRMMNVDMNEGHAYRLFKMADKSQTGTLEGEEFVLFYKALTQRDEVLEIFQEYSEDGKKLTLLEFVDFLQQEQMESSGIDELAMELIDRYEPSETAKARHILSTDGFLMYLCSPDGSIFNPEHTKVHQDLSQPLCHYFISSSHNTYLMEDQLRGQSSVEGYIRALKRGCRCLEVDCWDGSNGEPIVYHGHTFTSKIPFRDVVATLQKYAFRASEYPIILSIENHCSIEQQDIMAQHLKGILGEQLLLSTIDGRVPVQL... | 153 |
A0A5K1K9G0 | 3.1.1.4 | ACT_SITE 1168; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 1392; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MVKNVYIYFVYLVYLFHMFSLSLRMQKNIFKYITPLSNRFNLTKIRKLKLFRKEKQKKQVRVFNHVVNNYIGLDLFFTKLNNITSNHEKLNYINFLQQIVEDKAYEHLLFSNNYMRIIIYILNEKCLVIKKNEEKYDDLDYEIIYRILLIFKNLTRYKSFYHVILNDYTHKNKKISLLYTLMNILNEKNDFNNYSNNNFDKYKEYNSIFNYFTSFFKNAEDTKNYMTQDSSTELDSKMKNEEQEENEKINEINKMKNKIYDIGRNILLKLKDEKLKVENKINSQYVRGSNHFTNETSTDLKSTKDQEDILLEEKKKSDDE... | 130 |
C8VBA9 | 3.2.2.27 | ACT_SITE 182; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MLLLLSPYTHLPNIHAATHQAHRSFRLPIDSCLHSYNRHTMASPSLKRSAGDLANPAVESKRPKTNGSITSFFGAPKPKENGAATTKSAVPSSVSSFNKQKWVATLTPEQKELLRLEIDTMDESWLAHLKEELIKPEFLALKRFLQKEKQMGVKVFPPEEDIYSWSRHTPLHKVKVVVIGQDPYHNYNQAHGLAFSVRPPTAAPPSLVNIYASIKNDYPSFVPPPNKGGLLIPWAERGVLLLNTCLTVRAHQAASHSNKGWERLTQKAIDVVTRVRTRGVVFLAWGTPAGKRITGINRDRHCILQSVHPSPLSAHRGFLN... | 173 |
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