Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A2C9W4W9 | 3.1.1.11 | ACT_SITE 453; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVFQDFDRISERRRLEREQKFKRRVIIAFISLLALLVIVAAGILFIIWDNSINSAKRHQQHQEQEQQRQHQQHQQPKGEEATQPKEPSKNNVAQVSKVLKKICNATTYKETCLSSIKDAVEKDPSAPHPKAIIKLGIQSTKDEVGKVLDKASSFNFNTPQEKAAFEDCKVLMADAKQELEESISHADSDDGNFKKNEAELNNWLSAVMSYQQTCIDGFPEGKLKSDMENVFNASKELTSNSLALVSSLTSILQSLLISQSGRRLLTKEPNSFSMEEDGLPSWISHEDRRMLKAETERDDKPKPNVVVAKDSSGDFKTISA... | 125 |
Q336V9 | 2.7.11.1 | ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGCCGSSLRVGSHAPEKPPRRARPPPPPPQPHHPRRPSFTLNAHQAAASSSAASAAPAPAFAEFSLAELREATGGFAAANIVSESGEKAPNLVYRGRLQGAGGGGRAIAVKKFGKLAWPDPKQFAEEARGVGKLRHRRMANLIGYCCDGDERLLVAEFMPNDTLAKHLFHWENKAIEWAMRLRVAYNIAEALEYCSNEERPLYHDLNAYRVLFDENGDPRLSCFGLMKNSRDGKSYSTNLAYTPPEYLRNGRVTLESVVFSFGTILIDLLSGKRIPPTLALDMIRSRSIQAIMETNLEGKYSIEEATTLVDLASKCLQYE... | 99 |
P48966 | 3.1.3.48 | ACT_SITE 481; /evidence="ECO:0000250|UniProtKB:P30304" | MEVPPQKSAPGSALSTARVLGGIQRPRHLSGFGFGSDGLLGSPERAASSSPVTTLTQTMYNLAGLGSETPKTQVGSLSFQNRLTDLSLSRRTSECSLSSESSESSDAGLCMDSPSPMDPQTAERTFEQAIQAASRVIQKMQFTIKASVFASEAAGHSPVLQNITNSQALDSWEKDEAGYRAASSPGEDKENDGYIFKMPQKLPHSSSARALAEWASRREAFTQRPSSAPDLMCLTTDGKMDVEEASPVAQSSSLTPVERACEEDDGFVDILESDLKDDDMVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSM... | 149 |
F6HGZ2 | 3.1.1.11 | ACT_SITE 366; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKGRANLSGVLLEIRASALNYSNASYTSLKSVTSFCKSTPYPDVCFQSLKVHVSININPNIITFLLHSLQTAISEAGKVSTLLSTAGQHSDVIEKQRGTIQDCRELHQITVSSLQRSVSRVRSGDSQKLKDARAFLSASLTNKVTCLEGLDSAAGPSKPTLVNSIVAAYKHVSNCLSVLSKSTPQKGPINRRLMGAPAWASRRILQSSGDEYDPSEVLTVAADGTGNFTTVTDAINFAPNNSNDRIIIYVREGVYEENVDIPSHKTNIVFLGDGSDVTFITGSRSVVDGWTTFRSATVAVSGEGFLARDITFENRAGPEK... | 125 |
A0A2C9W1G1 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTSFKLNSLTTLPSFIVFLVFCSSVNVSFASLRVGFYRSSCPSAEAIVRKAVNKAVSQNPGLGAGLIRMHFHDCFVRGCDASVLLKSTPGNPSEREHVANNPSLRGFEVIDEAKAEIEALCPQTVSCADILAFAARDSSYKLGGINYVVPAGRRDGRVSREDEVGQNLPPFFFNAQQLADNFARKGMSVDEMVTLSGAHSIGVSHCSSFSSRLYNFNATHAQDPSMDPRYAAFLKTKCPPPSANRVDGGPTVALDPTPNRMDNKYYMELKKNRGLLTSDQTLMNSASTQMMVVNNARNAGTWAAKFAKAMVHMGSLDVLT... | 14 |
A0A8I7B586 | 1.11.1.7 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAVKLAAFVVVALLGCMAYTCQASYGYPNPMPPIISPTPPTAPALTLDYYSYSCPNAEAIVREAVKNATANNRGIGAGLIRLFFHDCFVRGCDASVLLDPTSANQEPEKLGIPNFPSLRGFEVIDAAKAKLEKECGGVVSCADIVAFAGRDATFFLSNGVVDFKMPAGRYDGRVSFANETLRDLPPPFANVKVLEAMFEAKGLDLDDMVTLSGAHTIGISHCSSFADRLPANPSDPTSMEPTLASSLQQTCNRGGDPVVVQDVVTPRDLDRQYYQNVLDRKVLFKSDATLLQSPQALKAVEHNAKNPGKWERKFKQAMV... | 14 |
Q81WH6 | 2.7.11.1 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLIGKRLNDRYKLLKMIGGGGMANVYLAHDDILGRDVAVKILRLDYSNNEEFIKRFHREAQSVTTLSHPNIVNMYDVGEEDGIYYLVMEYVPGQTLKQYIIERGMLPIGEALDIMEQLTSAMAHAHHFEIVHRDIKPHNILIRADGVIKVTDFGIATATSATTITHTNSVLGSVHYLSPEQARGGIANKQSDIYSLGIVMFELLTGRQPFSGESAVAIALKHLQSEIPSPKRWNENIPQSVENIILKATAKDPFHRYQSANAMKRDIETALYPERINEQPFYIPEDMEATKAIPIIQQEQLFENVTDETIVLKGSKVDEQ... | 99 |
P13433 | 2.7.7.6 | ACT_SITE 945; /evidence="ECO:0000250"; ACT_SITE 1014; /evidence="ECO:0000250"; ACT_SITE 1189; /evidence="ECO:0000250" | MLRPAYKSLVKTSLLQRRLISSKGSKLFKPSPDSTSTILISEDPLVTGSSPTSSTTSGIISSNDFPLFNKNRKDAKSSISYQWKNPSELEFDPFNKSHASAVTSMTRTRDVMQLWSLLEACLQSNLMKRAFSILESLYLVPEHKQRFIEDYNMYLNSFSKNDPNFPILKMNEKLTNDLETSFKDVNYNDKTLAIMIHHALNFHSTTSSMLLKPIISAYLKMSVNGIREIFSCLDILTISDLNILMNDLKVITPSQLPNSVRPILESLTLSPTPVNNIENEEGLNKVEAENDSKLHKASNASSDSIKKPSLDPLREVSFHG... | 119 |
A0A078IWR4 | 1.11.1.7 | ACT_SITE 87; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANGLSKRIFTFLMLISLVAVALNLLATVEAQNKKKPRRDVPIVKGLSWSFYQKACPKVEKIIRKELKKVFKNDIGLAAAILRIHFHDCFVQGCEGSVLLDGSASGPGEQSSIPNLTLRQAAFVVINNLRALVHKQCGQVVSCSDTLALAARDSVVLSGGPDYDVPLGRRDSLAFASQNTTLNNLPPPFAKASQLITDFANRNLNITDLVALSGGHTIGIAHCPSFTGRLYPNQDPTMNKFFANSLKRTCPTANSSNTQVNDIRSPDVFDNKYYVDLMNRQGLFTSDQDLFVDKRTRGIVESFAIDKKLFFDHFAVAMIK... | 14 |
H2LEM1 | 2.7.11.13 | ACT_SITE 559; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MVVFNGQLRIKICEALDLKPTAWSLRHAVGPKTQTFLLDTYIALNVDDSRVGQTSTKQKTNSPTWNDEFTTEVHDGRRIELSVFHDAPIGYDDFVANCIIQFEDILHNGSKHLEEWIDLEPEGKVYVVIDLIGSSSEVSSENEERVFRQRMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCAGMKKQDNTVGEPVGSQRFSVNVPHMFSIHNFKVLTFCDHCGSLLWGLLRQGLQCKVCKVNVHRRCESNVAPNCGVDARGIAKVLSDLGVTPDKISNSAQ... | 100 |
A0A1U8HH24 | 3.1.1.11 | ACT_SITE 219; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MESCSFLLFYFCFVFVFASFFCPAPSLSVATRPVVNQTACTTNSTRHRHKWIGPIGHRLITVDINGLGHFRSVQDAVDAVPENNRKNVLIRISAGYYIEKVVVPATKPYITMQGAGREVTFIEWHDRASDLGSNGQQLRTYQTASVTVYANYFSARNISFKNTAPAPMPGMQGWQAVALRISGDKAYFSGCGFYGAQDTLCDDAGRHYFKECYIEGSIDFIFGNGRSMYKDCELHSIATRFGSIAAHDRNSPDEKTGFAFVNCKVTGTGPLYVGRAMGQYSRIVYAYTYFDDLVAHGGWDDWDHVSYKNKTAFFGVYKCW... | 125 |
Q9XAC1 | 2.2.1.1 | ACT_SITE 435; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MSTKPTTTDLEWTELDQRAVDTARVLAADAVQKVGNGHPGTAMSLAPAAYTLFQKVMRHDPADANWVGRDRFVLSAGHSSLTLYTQLYLAGFGLELADLESFRTWGSKTPGHPEYGHTTGVETTTGPLGQGVANAVGMAMAARYERGLFDPEAAEGESPFDHFVYCIAGDGCLQEGISSEASSTAGHQKLGNLVLLWDDNHISIEGDTETAVSEDTCKRYEAYGWHVQRVAPKPDGDLDPNAIYDAIEAAKKVTDRPSFIAMRSIIAWPAPNAQNTEAAHGSALGDDEVAATKRVLGFDPEKSFEVSDEVIEHTRKALEK... | 51 |
D6WRR8 | 3.2.1.52 | ACT_SITE 339; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MFKLFFLLLIISFCSAFDFIFQPGPLVPASKGEIWPKPQHENKLDDGFFSLLPTFFHFNPIGNICNTLTEALDRYRKLIIFNNRRIKEVYYKARSCYEGGDQNFLGYLTSVEVELTGACNDEEYPSFEMKEEYVVNVTSTVQRISSDTIWGILRGLETFSQLIYLTDDYSCHRIGTTSIHDYPRFAHRGLLLDTSRHYIPKEHILKLIETMSYNKLNVFHWHITDDYSFPYVSKAFPQMSNKGAFHPTLMIYEQDFVSEVQEYARKRGIRVLAEFDTPGHTLSWGLGNPDLLTDCHNVPQLKWGPINPIKNTTYDFIFKL... | 170 |
D2WL32 | 2.4.1.18 | ACT_SITE 612; /note="Proton donor"; /evidence="ECO:0000250" | MVSLSNQTRFSFHPNNLVVSEKRRLGISGVNFPRKIKLKITCFAAERPRQEKQKKKSQSQSTSDAEAGVDPVGFLTRLGIADRIFAQFLRERHKALKDLKDEIFKRHFDFRDFASGFELLGMHRHMEHRVDFMDWGPGSRYGAIIGDFNGWSPTENAAREGLFGHDDYGYWFIILEDKLREGEEPDELYFQQYNYVDDYDKGDSGVSAEEIFQKANDEYWEPGEDRFIKNRFEVPAKLYEQMFGPNSPQTLEELGDIPDAETRYKQWKEEHKDDPPSNLPPCDIIDKGQGKPYDIFNVVTSPEWTKKFYEKEPPIPYWLE... | 73 |
A0A078GYI3 | 3.5.4.5 | ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MDRPSFLIHAEEAESAAKRHGVSVVNLLPLLVNPAKPLARPPISKFPVSAVGLGSSGRIFVGVNVEFPGLPLHHSIHAEQFLVTNLTLNSEPNLRHFSVSAAPCGHCRQFLQEIRDAPDIKILITDPNAFRDAKEEDGYVRLESILPHRFGPNDLLERDVPLLLEPHDNRLTLLGVTNGHVDSDLKLTALSAANRSYAPYSRCPSGVALVDCEGRVYRGWYMESAAYNPSLGPVQAALVDYVANGGGGGFERIVGAVLVEKRDAVVRQEHTARMLLQVIAPKCDFEVFHC | 187 |
W5N2C4 | 2.7.10.1 | ACT_SITE 1070; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | IKTLTLNLAFMWIGICFTSSQVTGYSMTPPTIDSLKEDLVIDANDTLTITCRGQHTLDWAWPEKSLRKQEVKDRQDQLYPTVLPGHRAVWVKECQGEPGKPYCKTLVLTRACGNDTGYYRCFYKDVKAAIDGATAASIYAFVKDETQPFVKGNSDAVEAVFISSLSTHVEVPCRVTVPDVEVKVGLFDAGVGVPLDEKQLIWNNKKGMSIPTQLIVTRTTLLGLYCQTFLNNVEYRSPVFLTHFTGTIVYDFKLYPEESVELMMGETLVLNCTAFVEFDTAVHFNWTYPGKKANRSVHIHHERNSLTHKTEASSTLVVHS... | 97 |
Q6I587 | 2.7.11.1 | ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGARASRHRQSPDQSQSQSPSPHHKHHHHHQTTRAPKPKPKPQPPPPQQPRSQPPPPPRHQPQQAPQQAAAEDGVGRVLGRPMEDVRATYTFGRELGRGQFGVTYLATHKPTGRRYACKSIAARKLARPDDLDDVRREVHIMHHLTGHRNIVELRGAYEDRHSVNLVMELCEGGELFDRIIARGHYSERAAAALCREIVSVVHSCHSMGVMHRDLKPENFLFLNKREDSPLKATDFGLSVFFKPGEQFRDLVGSAYYVAPEVLKRLYGAEADIWSAGVILYILLSGVPPFWAENEDGIFDAVLQGHIDFSSEPWPSISSG... | 99 |
Q81AK7 | 1.1.1.100 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MEFLNGKTAVVTGAAQGIGKEIARVYAKLGAKVLISDVNEENLQKTTRELSDEGYEVCSYRCDVSNQNEAKSLIEYAVQKFGTLHILVNNAGITRDAMLHKMEKSAWEQVLQVNLTGVFYCMQPALLYMRQQGYGRIINISSISREGNIGQANYAATKAGVVGLTKTAAKEVGSFGITCNAICPGFMDTDMTKTIPDKVKEKMVGAIPVGRIGTPEDIANAAAFLASEYASYITGEVLNVSGGLQV | 2 |
A0A1U8LP36 | 2.1.1.37 | ACT_SITE 791; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MEPTENSDSDSKSQSLTLVTTGDDNVEQPLPLEICVPEEIAAGADDNKLLPRRSPSIFQLFPIRSVFSRKSDIETVLKRCLRRSPRNSALVVRESANVRPKAIVSLETEGYKRKIKESTTVEGKNLRRSPRFTTISAAAENKKVLSLSSKSRSSKSQRFKLKNKGAKIMNIERTNGMGLRRSPRLTSAPPETKGRSSKTIFKSSDKGSYSETRSSGKLNGKRLCLSKTEEADKGTFPLRRNETNLRLIIERQLRRSLKFSQATKNGSSDIPVRRLDMDEVVFSEEKLLGISPSSMHATENGGSNASFREHRREISDEKQF... | 47 |
A0A2R6WDK3 | 2.7.1.11 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03185" | MGVPLVELSTLQHVRTAYKARLPPALQGSHVELVRGDSTVAADPADALVISRSFPLTYGLPLVHLKAPSGTENGNSQSENGVSQSVPLRVGVVFCGRQSPGGHNVVTGLFDALKAHNTSNVLLGFVGGTEGLFAQKTLEVTEDLVRTYRNQGGFDMLGRTKDQLRSLQQVNDARAACEALKLDALVLIGGCGTNTDAAQLAETFTATNCHTKVIGVPVTIDGDLKNQFIETDVGFDTTCKVYSQLISNICIDALSAEKYYYFIRLMGRRTSHITLECTLQSHPNMVILGEEVSTQKMTLFDITKQICDVIQARAETEKYH... | 84 |
A0A251RBW8 | 3.2.1.1 | ACT_SITE 219; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MNIRCHPTHPIAHTTSKGNMNFLLSFCFCLCVSRLPSFATPAVLFQGFNWDSSKKGGWYNSLKTTIPELASSGITHVWLPPPSHSNGTEGYDPGRLYDLDASSYGNKDELKSLIATMHEKGIKAIADIVLNHRSAVKQDENGIWSIFEGGTEDGRLDFNASLICRDDNDHPFGTGNPDTGDNFPYTADVDHTNPRLQTELSDWLNWLKTDIGFDGWRLDYVIGYGSSFTKLYMEKTSPEFAVAEYWRWNISKGQDGKLDKNQDAHRNEIVNWIEAAGGVVTAFDLTTKYILNVAVEGELWRLKDSNGKPPGLIGIKPESA... | 157 |
P13677 | 2.7.11.13 | ACT_SITE 495; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAAAVATPGATVLPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEH... | 100 |
P0CP70 | 2.7.11.1 | ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPDSNAQGSREKESGHHRSHKERIGNYVVGAEIGRGSFATVYKGYRSKTRVPIAIKAVSRQKLTSKLLENLESEINILKVINHRNIVALTDCFKNDTHIYLVMEYCSGSDLSVYIKQRGNIPTLDFVPKAGSSMALLPTDDEGKIYWPHPPTGGLDERVTRSFLGQLAQAIKFLRAQDLMHRDIKPQNLLLQPATETEVAEGHPYGIPVLKVADFGFARILPAAAMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLFEMSVGRPPFRANNHVELLRRIEKSNDNIVFPDEKERDSKSSDETSIPVPSDIKALIRAL... | 99 |
A1L1L3 | 3.1.3.48 | ACT_SITE 354; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MSSPGNVRQKHGRDNDEHEGDSDDLNLQKSLPSSSQQKTPTKPVFGNKVNSESVKTSHHMSFSNKYDLVFPEPVESDNDETLWDVRDLSHRNRWSSVDPESAGPSKTVSTVLSESSTDTAVSERELTQLAQIRPLIFNSSSRAALRDCLKALQKKEELDIIREFLELEEMIPPDDFKSGYELQNRDKNRYRDILPYDSTRVPLGKNKDYINASYIRIVNHEEEYFYIATQGPLPDTIEDFWQMVLENNCNVIAMITREIEGGVIKCCSYWPVSLKEPLEFKHFHVLLENFQITQYFVIRIFQIVKKSTGKSHSVKHLQFI... | 149 |
Q8K387 | 3.4.19.12 | ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 745; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MRVKDPSKDLPEKGKRNKRPLLPHDEDSSDDIAVGLTCQHVSYAVSVNHVKKAVAESLWSVCSECLKERRFCDGQPVLPADVWLCLKCGLQGCGKNSESQHSLRHFKSSGTESHCVVISLSTWVIWCYECNEKLSTHCNKKVLAQIVDFLQKHAFKTQTGAFSRIIKLCEEKREAGEIKKGKKGCTVPSVKGITNLGNTCFFNAVIQNLAQTYILFELMNEIKEDGTKFKISLSSAPQLEPLVVELSSPGPLTSALFLFLHSMKEAEKGPLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQASILK... | 175 |
Q66GN2 | 2.7.11.1 | ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGRAKSMVSLLLVLFLVRAHVATTETTTEFIFHGFKGNQSEIHMQGDSTITSNGLLRLTDRNSDVVGTAFYHKPVRLLDSNSTNTTVRSFSTSFIFIIPSSSTSNGGFGFTFTLSPTPNRTDADPEQYMGLLNERNDGNSSNHVFAVEFDTVQGFKDGTNRIGNHIGLNFNSLSSDVQEPVAYFNNNDSQKEEFQLVSGEPIQVFLDYHGPTKTLNLTVYPTRLGYKPRIPLISREVPKLSDIVVDEMFVGFTAATGRHGQSSAHYVMGWSFASGGEHPLAAMLDISQLPPPPPNKAKKRGYNGKVIALIVALSTVISIM... | 99 |
H2LDA6 | 2.7.11.1 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038189-1" | MDSSVTSATYVRNISYSLRRKLSDCLDPYETWRDLIVALRKPNGEPRYTQHHVRRFEGLVAQGKSVTVELLNDWGTTNSTVGELVDILRSLNLLAAANLLLPEVLSKETQQVSSVKAEKCPPTLLLGEAPNPPAGSSLQTQTLLDDGGDDTGVSRFLYGELMRITRNFDDRSISDGGSRIGAGGFGTVYKGLLDSRLVAVKKLSPMEDMPLESLQLQFNQEIQTLKVLKHQNLVDMVGFSSDEQHLCIVYALMANGSLLDRLACLDGSPPLSWQLRCFISEGAARGLEYLHSNHHVHRDVKSANILLDENYVAKISDFGL... | 99 |
A0A0I9QGZ2 | 2.2.1.1 | ACT_SITE 412; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P27302" | MAHSIEELAITTIRTLSIDAIEKAKSGHPGMPMGAAPMAYTLWTKFMNHNPANPNWFNRDRFVLSAGHGSMLLYSLLHLSGYDVSMDDLKQFRQWGSKTPGHPEYGHTPGVEATTGPLGQGIAMAVGMAMAERHLAATYNRDGFEIINHYTYAICGDGDLMEGVASEAASLAGHLKLGRLIVLYDSNDISLDGELNLSFSENVAQRFQAYGWQYLRVEDGNNIEEIAKALEEARADLSRPTLIEVKTTIGYGAPNKAGTSGVHGAPLGAQEAKLTKEAYRWTFAEDFYVPEEVYAHFRATVQEPGAKKEAKWNEQLAAYE... | 51 |
Q4Q9X3 | 2.1.1.37 | ACT_SITE 453; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MTSARSYPPLYPAGVFVVRSKQELAPLVARLRAARRLKPGRNVTVFDGEHFAEVADALEIRLSASAPEGRGGGASEDAACSLRETLVHLRETTEAEAAELVMATQTGGRTGLSGNDGIIALLPTSLSTSEAHSTNARASAPAVMYERCALITARDSVEGEEFLSLLRVPCAERAGTRWPLYMAAHVVGEFAETELRTLFSSDGSSGGPSTESDGADGHEPMKSSTPVAYIRGVRRFHRVCCPVLAEMPSALAAMRRTALLQRHHRLVQRGEAAADSPCAPPSSETGAPSLSAATLQRSSAPPGGLSRDANTACSPFFTFS... | 47 |
Q9M0E5 | 2.7.11.1 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNKIARTTQVSATEYYLHDLPSSYNLVLKEVLGRGRFLKSIQCKHDEGLVVVKVYFKRGDSIDLREYERRLVKIKDVFLSLEHPHVWPFQFWQETDKAAYLVRQYFYSNLHDRLSTRPFLSLVEKKWLAFQLLLAVKQCHEKDICHGDIKCENVLLTSWNWLYLADFASFKPTYIPYDDPSDFSFFFDTRGQRLCYLAPERFYEHGGETQVAQDAPLKPSMDIFAVGCVIAELFLEGQPLFELAQLLAYRRGQHDPSQHLEKIPDPGIRKMILHMIQLEPEARLSAEDYLQNYVGVVFPNYFSPFLHTLYCCWNPLPSD... | 99 |
A0A3B6EI07 | 3.5.4.5 | ACT_SITE 92; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MGEERMTAKPEAVELPGFVMSADEAERAAAAAGVETVEDLLPLLIPSAMRRARPPISRFPVGAVGLGESGRVYAGVNLEFVGAPLSQAVHAEQFLIANAAAAGEPALRAIAVSHMPCGHCRQFLQEIRGAAGIRILVTSDAADGCAAEWRSLASLLPRPFGPHDLLPKDAPLVLEPHDNRLGDPVDAAANGFAAGDLEGRLKDAAEAAARAAHAPYSGCPSGFAVADGEGKVYAGGCLESAAYNPTLGPVQTAIIAMIAASGGSAGDVVAAALVEKEGAVAAQEATARVFLAAVAPQASFHVYKYRSSDV | 187 |
F6RWR2 | 2.7.10.2 | ACT_SITE 683; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MGFSSELCSPQGHGALQRLQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMALQEGGSQVRNLDHVSQISQSWAEITRQTESLSRLLRQHAEDLNSGPLSKLSILIRERQQLRKSYSEQWQQLQQDLTKIHNLDIEKLKSQYRVLARDSAQAKRKYQEASKDKDRDKAKDKYVRTLWKLYAHHNRYVLGIRAAQLHHQHHHQLLLPGLLQSLQDLHQEMALILKEILQEYIEISSLVQDEVVSIHREIAAAAACINPHTEYEGFLQQYGSPPSAPPCVAFDDSLLEEGEQLEPGELQLNELTIESVQHSLTSVNEELTTA... | 98 |
A0A8M9PRV2 | 2.7.11.1 | ACT_SITE 200; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037568-1" | MEMSIGESLTARFEKIDAMLKDPKSEVNTDCLLDSLDALVYDLDFPALRKNKSIDDFLKRYKDTISKIRELRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPEDSDISKDAKSLICAFLT... | 99 |
P19172 | 3.2.1.14 | ACT_SITE 156; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258" | MTNMTLRKHVIYFLFFISCSLSKPSDASRGGIAIYWGQNGNEGNLSATCATGRYAYVNVAFLVKFGNGQTPELNLAGHCNPAANTCTHFGSQVKDCQSRGIKVMLSLGGGIGNYSIGSREDAKVIADYLWNNFLGGKSSSRPLGDAVLDGIDFNIELGSPQHWDDLARTLSKFSHRGRKIYLTGAPQCPFPDRLMGSALNTKRFDYVWIQFYNNPPCSYSSGNTQNLFDSWNKWTTSIAAQKFFLGLPAAPEAAGSGYIPPDVLTSQILPTLKKSRKYGGVMLWSKFWDDKNGYSSSILASV | 158 |
B9T322 | 3.4.21.92 | ACT_SITE 171; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 196; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MEKGLSFISVSQSTSSPLCFSNHKQFLLPTINTTDSNKAKVSISTNGKRRKPISVKAVNTRKETLSSNWDVANFSSSFATSSPALPRFEELDTTNMLLRQRIIFLGSQVDDMTADFVISQLLFLDAEDPTKDIKLFINSPGGSVTAGLGIYDAMKLCKADVSTICLGLAASMGAFLLAAGTKGKRFCMPNGRVMIHQPLGTAGGKATEMSIRIREMNYHKIKLNKILSRATGKPVEQIEVDTDRDNFMSAWEAKEYGLIDVVIDDGKPGLVAPLTDASPPPKTRVWDLWKIEGGKKAKKNLPSEHKILRNGYAGRQGDDE... | 179 |
Q4WP47 | 4.1.1.17 | ACT_SITE 391; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MVMAPTACVPAEVCMTKHCHDINDYNFNYHSQLSNHGGDDLSQSRLAAKNLVLDVLKKRAAEVDVDRCGPGEEDAFYVADMGEIYRQHLRWKMNLGRVKPFYAVKCNPDPEILRLMAKLGNGFDCASKAEIDLALETGIDPSRIIYAQPCKTKSYLRYAAKVGVKQMTFDNADELYKIKACYPDAELYLRILTDDSTSLCRLSMKFGASLDIARQLLELAHELELKVVGVSFHVGSGAEDPRAFLKAVQDARLVFDQAAEVGHELHTLDVGGGFCQDTFEKFAGILSEALDTYFPPHIRVIAEPGRYYVASAFTLAANVI... | 195 |
Q09315 | 3.1.3.5 | ACT_SITE 119; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9D020"; ACT_SITE 121; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q9D020" | MSNKVARRLGKCLFVSGRRFESRQSILQLRTETLTDTPLSATLDQSQFSMFKAAEIVNAAAACAEAECIEQLKKTDVVPLLMNYLLGEEQILVADPTAVAAKLRKMVVGGAGKTVVISDFDYTLSRFANEQGERLSTTHGVFDDNVMRLKPELGQKFVDLKNKYYPIEFSPNLTMEEKIPHMEKWWGTSHSLIVNEKFSKNTIEDFVRQSRIVFKDGAEDFIEALDAHNIPLVIFSAGIGNIIEYFLQQKLGAIPRNTHFISNMILFDEDDNACAFSEPLIHTFCKNSSVIQKETSFFHDIAGRVNVILLGDSMGDIHMD... | 150 |
P38623 | 2.7.11.1 | ACT_SITE 313; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLKIKALFSKKKPDQADLSQESKKPFKGKTRSSGTNNKDVSQITSSPKKSFQDKNIVQYPSVVADDHHMKSLTDELVTTIDSDSSPSDNITTENVETVTSVPAIDVHESSEGQLSSDPLISDESLSEQSEIISDIQDDSTDDDNMEDEIPEKSFLEQKELIGYKLINKIGEGAFSKVFRAIPAKNSSNEFLTKNYKAVAIKVIKKADLSSINGDHRKKDKGKDSTKTSSRDQVLKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEIVRLTYFSEDLSRHVIKQLALAVKHMHSLGVVHRDIKPENLL... | 99 |
P9WHN7 | 3.1.1.29 | ACT_SITE 22; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKRSGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRIRLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVPTICEQAADATELLIEQGMEPAQNRVHAW | 127 |
O27270 | 3.4.25.1 | ACT_SITE 10; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVADAQSLMKYLKAEAALYRMRNSEKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKIYSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDEAVDVAIRAIKSAMERDTYSGNGILVATVTEEEGFRMLSEEEIQKRIENLN | 180 |
Q2QXC6 | 2.7.11.1 | ACT_SITE 180; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9JIH7" | MDLVEAEAEEQPPDEDGDEEGYVEADPAGRFIRYDEIVGSGAVKTVYKAFDKLEGVEVAWSQSRIDDSVMGSSKKMKQLNTEIQLLKTLKHKNIEKMFASWVDGEKKTVNIITELFTSGSLTQYRRKHKKVNMKAMKRWAIQILTGLEYLHSQKPAIIHRDLKCDNIFINGNHGKVKIGDFGLATFMQQQKKSIKGTLEFMAPELLTGHYNELVDIYSFGMCMLEMVTCEYPYSECQGMAHIFKKIDEGKKPAAFYKIKDAEVRSFIENCLAPVENRMSATELLKSSFLQDDDLISVSLVKNMSEDGQQPVSCMLRKGEF... | 99 |
F1A274 | 2.7.11.1 | ACT_SITE 775; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MPQKPNKSNNKTKQPQQLQQQQQQQQQIQQQLLQQNVLIDDILSSDEEDPKVPSKSSVKNALKKARKERDRELIKQLKEQQDMEIDALQAIYQDEFITMDPIVITKNMDTIIEGIKPVKESSRFRITLKPYVGDDEKCFISVYLCIGFPEKYPVVLPNIQVLPNKGISQKKASELEEKLQKESQGKIGNIMIFDLCEIVKEFLQIYNSEPTQSMHQQMLTDQKDSKKLSIEVGSMNDPNYNLNIDKKEWESALEESQLKDDRKNFRLQKSMQRAHFERERKKNIVNELTNNTFTQNSPTYTNDYSMVAMMATEEQIQQQQ... | 99 |
A0A067ETU4 | 3.1.3.16 | ACT_SITE 362; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MPNMETENSSVSRAEELKALANEAFRAKKYSQAIDLYSQAIELNSQNAVYYANRAFAHTKLEEYGSAIQDASKAIEIDPRYPKGYYRRGAAYLAMGKFKEALKDFQQVKKLSPNDPDAAQKVKECEKAVKKLKFEEAIAVPESERHSVADSIDYQSIGMSPSSSFVSTQAAILAATATVVVAVVVMVWPAVATTVAGMVVAVLMILGAYWWGSCSGSDVFTKSRKLELEVEPQYSGARIEGDVITLDFVKKMMDDFKNQKCLHKRYAFQIVLQTREMLRALPSLVDIDIPDGKHFTVCGDVHGQFYDLLNIFELNGLPSE... | 144 |
A0A3B3I772 | 1.1.1.8 | ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MRTEFKGQLCYKAVKEVSAAVCHRTGCSGKYKGLHTFTMPGKKVCIVGSGNWGSAIAKIIGHNVKASNRFDPMVNMWVFEEIINGKKLTEIINTEHENVKYLPGHMLPKNVVAVPDITDAVKDAKILVFVIPHQFINKLCNQMKPHVAPGAIGISLIKGIDEGPEGLKLISDIIREKLEIDVSVLMGANIANEVADEKFCETTIGAKNEGNGLIFKELMQTPNFRITVVPESDTVELCGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMVAFAKLFCKEQVRSGTFLESCGVADLITTCYGGRNRKVAEAFVKTSK... | 7 |
Q6C579 | 4.1.1.50 | ACT_SITE 82; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 96; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 311; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT... | MILEHHVNHQVAVDLDSAEAFEGPEKLLEVWFAPNQESLEGTNKSLRNVSTAQWEQLLNIVQCKVLSSVHTSVLDAFVLSESSMFVFPHKLVLKTCGTTTLLVGIPKMLEIARTIAGFGANATPYRVFYSHKTFNCPEKQAPPHKSWKDEVSYLDSQFDNGKAYLVGDTTSDHHWYCYVTGHDDHEEVAAHKDHVISSHDETMEILMTDLLPSRAQQFFTDRLPGDANNAGFQHKQELLVGVEHVVKAETDSATSSDSEGATPACSGTCKADPGHVLGAYVSTQSGIADIYPRNKASVAVDSFCFTPCGYSANAIVDSGY... | 196 |
A0A8V1AMK5 | 2.7.11.13 | ACT_SITE 542; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000550-1" | MADVFPGSEPGAAPDAARRFARKGALRQKNVHEVKEHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQAARNAPLVRRRGTDAVLGSTSVSFCVNQPSGNITKLLEYKMHLLEICLSLLCNRMGRTLPADTRLSAAVLGRGPRAHVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLLHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTGDKLEVTVREAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTFRSTLNPHWNESFTFKLKPTDKDRRLSVE... | 100 |
P52905 | 3.4.21.4 | ACT_SITE 68; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 113; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 206; /note="Charge relay system"; /evidence="ECO:0000250" | MAVYGIVATVLVLLLLGDASDVEATGRIIGGSDQLIRNAPWQVSIQISARHECGGVIYSKEIIITAGHCLHERSVTLMKVRVGAQNHNYGGTLVPVAAYKVHEQFDSRFLHYDIAVLRLSTPLTFGLSTRAINLASTSPSGGTTVTVTGWGHTDNGALSDSLQKAQLQIIDRGECASQKFGYGADFVGEETICAASTDADACTGDSGGPLVASSQLVGIVSWGYRCADDNYPGVYADVAILRPWIVKAANAI | 177 |
A0CCD9 | 3.4.19.9 | ACT_SITE 139; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 251; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 251; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MPRILLLLSCILFLSQSSFVDDIEYLTEINNNVVIGIFTQPSDPDYVDYPSSQYSYLAASYVKFVEMAGARVVPIPYEADNTILEKYFLGINGIIIPGGASDLDTPTGPSKFAKAVAYMVNRALQVNEAGEVFPVFGICMGFQTLHYIISGYKTPFLYRVYGENGISHSLENGDRNFALYKDFDDDTYQAIQTNQYLYYSHNWGVSPDLYKKYPSLDAFFKITGTNQDNKGQTFVASMQGKQHPVFGVQYHPEKNIFEWKISAPHSYLAVKVSANHIDAFVNYARLNSHQFNAEQLNKAVIYNFKTVQEKNASFVQVYFF... | 176 |
B8LE83 | 2.7.11.1 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MEAEFLSKTKDDEAAKAGTRWTLQDFEIGKPLGRGKFGKVYLARERRTKYIVALKVLSKAQLLKSGVEHQLRREIEIQAHLRHRHILRMYGYFYDNKNIYLILEYSPGGELYKKLTAKGRFSERTAARFISDLSLAMKYCHSKHVIHRDIKPENLLLGAKNDVKIADFGWSVHAPTSRRNTLCGTLDYLPPEMVEGREHDEQVDTWALGVLLYEFLVGVPPFETESHGATYRRIQRVDIRWPSGMPEDAKDLISKLLKKDPRARLPLECVPKHPFVLRNLRV | 99 |
C5XKP4 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATSSLTFGVILSCALLLATATHGLQVGYYKKTCPSAEVLVRAAVKKALLANPGVGAGLIRMLFHDCFVEGCDASVLLDPTQENPQPEKLGRPNNPSLRGYEVIDAAKSAVEKACPGTVSCADIVAFAGRDASYLLSNSKVSFHMPAGRLDGRKSLASETGVFLPGPSSNLSSLVSAFAGKGLSAEDMVVLSGAHSIGRSHCTSFVQTRLSAPSDIAASLATLLRKQCPANPTTANDAVVSQDVVSPDVLDNQFYKNVLAHNVLFTSDAVLLSAPNTARMVRANARFAGSWEKKFAKAMVKMAAIGVKTGRDGEIRKNCR... | 14 |
Q7UJ74 | 2.1.1.77 | ACT_SITE 167; /evidence="ECO:0000256|HAMAP-Rule:MF_00090" | MMPKRKVIPKQQPLASNALSPTAVTLPSSISCGVGLVHSRLGRARSGWARFGWICVLISIVTPVWSQSPRSSRSHFNPSPLTSGSSLAQPPHLILGQTGSSRSAVDDRYAAARRKLVETRIRTAGVTNEAVLKSIETTPRHEFVPAAVRDKAYFDMALPIGSAQTISSPFIVASMTETLDPKPTDKVLEIGTGSGYQAAVLSPLVAEVYSIEIVDELGTRAAGVLSKLGYENVHTRIGDGFLGWPEASPFDKIIVTCSPESVPVPLVQQLREGGSMIIPVGERYQQTLYRMTKRDGELVREPLRPTLFVPMTGTAEDARQ... | 49 |
E3L321 | 1.1.1.37 | ACT_SITE 212; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MAIAPISSIIRHNVTPTIFKSHSVARQFSSSSQNFTKVAILGAAGGIGQPLSLLMKQSSLVSELALYDVQGSPGVAADVSHVNTASTCKGYLPDGEGLEKALDGAQIVLVPAGVPRKPGMTRDDLFNKNASIAADLATAAAKVCPKAHMLIIANPVNSTVPIVGEVFKKHNVFDPKRLFGVTTLDVVRASAFLSSLAKSHPKDTNVQVIGGHSGVTIVPLLSQVAQGKSITGEAYKALVKRIQFGGDEVVEAKSGAGSATLSMAYAAAIFTESLLKALGGARGIIEPTFVKSHLYEKEGVEYFASNVELGPEGVGKILPI... | 5 |
A0A8J8YC15 | 2.3.1.48 | ACT_SITE 551; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR003048-1" | MAEAGGVGPPALPPAPPHGSPRTLATAAGSSASCGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRGDLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPMVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPSKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTKVFGRTLLRSVFTIMRRQLLEQARQEKDKLPLEK... | 61 |
C5XTQ1 | 3.1.1.11 | ACT_SITE 417; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATFGRARPALPVIAWSCAMATALALATVMPVTSGKEDEAAAVSTIAAASPASTTNVTLLCRSTPYPRACETALTSAEARSARGPFAASVQFAMARATTTRALARNLSSSAAAPAPPAPSSGMHDCAELLGISLAQLRDALAGSAADADGATTWLSAALTNQGTCRDSLAAVPLPDDPAGSDAVRRQVAALARFISTALALHVGKVKKGETAAAAAGVPPSREGTAFPSWLSENDRKLLESLSPATTNDIVVTPDAVVALDGSGTHTSINEAIAEVTAEVDTEASGGRGVGISRRRKVIHVKAGRYEESVSISYQQADVM... | 125 |
Q9C8X7 | 2.3.2.23 | ACT_SITE 91; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MFKKMDKKAAQRIAMEYRAMISKESLFSIGQNSNNIYEWTAVIRGPDGTPYEGGMFNLSIKFPTDYPFKPPKFTFKTPIYHPNINDEGSICMNILKDKWTPALMVEKVLLSILLLLEKPNPDDPLVPEIGQLFKNNRFQFDQRAREFTARHANN | 64 |
Q9HQI9 | 4.2.1.11 | ACT_SITE 196; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 325; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MTRIEAVRYRPILDSRGNKTVEAEVTTDDGGFGRAAAPSGASTGEHEAVELPVGEAIAAGRERIAPRLEGREFAGDQRGVDAALHAADDTTDFSAVGANVAVATSMAAAKAAADVLGVHTYQHLGGALRGRNFPVPLGNVLGGGAHAADATAIQEFLVAATGAPSVRQAVFANAAVHQRVKDRLDDDGVPAAKGDEGAWAPSIDDATAFDVVAGAAAEVADEFGFDVRLGLDLAAAERYDGDEYVFGDDRRSTAAQIEYVAGLVSEYDLAYVEDPLDENDFEAFAELTDRVGDETLVCGDDLFVTNTERLQRGIDAGAAN... | 200 |
P0C1B1 | 2.7.11.1 | ACT_SITE 527; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSEDQGQQGQRLSTARGSTCLKQTMTEPALSAGLGTDGPVGAAKDNIRVRIQSRRRSRLLSRLGRKIPTQGRFTVGWYFWFLLIYTSLAVEPVKSHETHSHSSDAEGTSHQDVSDRRNHPCHTPRPSSHSQADSFESVARGQQKEQSRTMREDAVSPVLLDVKRSQSTPVELAKLVSLKLSTSFGSRTVIRRSQPGVRQSVRAAQLQRMMLDRGNPKRERSSGSSTPSSKSSPVDSVSTAPTSVSPGSLAPSGSTNNDPASGFKHIDSQADLPERPLSPVRESPMVSPTIQTTEATAIVKVFLETHFHTLLSGLDARTQR... | 99 |
A0A251N3P8 | 3.1.1.11 | ACT_SITE 429; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPSSPPLSVFVSHKHMSFPSSLHTTTTMYNLRRRTKLLLSVLPTSALLLILLFSNTHLRNSNSITPKTHVHNRIQLAAHSACQDTLYKDLCVSTLSTFPDLSTKSVPQIISYTVSHTVSEVQASSSNCTGIIKKQFKKLDALQQIALDDCLELFDDTIAELKAVISDLSVEKLSSDRYYDLKTLLSGAMTNQYTCLDGFNDTGIVRHEIQSRLQTISQHVSNALVMLKKIPGALKYENSKSSTSSEMFPEFGPMRNGFPTWVSSKDRKLLQSVVNGTKYDLVVAKDGTGNFTTISEAVAVAPNSSATRFVIYIKSGAYFE... | 125 |
A2A8L5 | 3.1.3.48 | ACT_SITE 1539; /note="Phosphocysteine intermediate"; /evidence="ECO:0000250"; ACT_SITE 1830; /note="Phosphocysteine intermediate"; /evidence="ECO:0000250" | MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPK... | 149 |
Q94JM2 | 2.7.4.8 | ACT_SITE 127; /evidence="ECO:0000250"; ACT_SITE 221; /evidence="ECO:0000250"; ACT_SITE 232; /evidence="ECO:0000250" | MIRKLCSSFSRSIIFPNKPIFIPRSFPQPLRHSSALSYSSLKMTDTHIPGNPNSSPIQSPTKPESLRSLEFQLGSSFTADPIIPPPNQIVIVISGPSGVGKDAVINKLREVREGLHFVVTATSRPMRPGEVDGKDYFFVSRDQFLSMVENEELLEYALVYGEYKGIPKKQIQEFMAKGEDIVLRVDIQGAQTLRRILGNSAVFIFLVAESELAMVERLIDRKTESQEELLVRVATAREEVRHLKNFDYVVVNAKGRLDDAVNRVESIIDAEKSKVHQRIVRI | 112 |
Q757L1 | 3.2.1.28 | ACT_SITE 465; /note="Proton donor/acceptor"; /evidence="ECO:0000250"; ACT_SITE 660; /note="Proton donor/acceptor"; /evidence="ECO:0000250" | MLQGMPKRSGSISELHDPFSSPDVYYGPATDPRRQKQPNKYSRTRTMSIIENVSTFKSAGKQYNIRRRGSEDDSMLASSGHRKFYIKDVDKTLEELLESEDTDGNYQITIEDRGPKTLRVGTANSNGFRHVQIRGTYMLSNLLQELTIAKNFGRKQVILDEARLNEDPVNRLTRLITHQFWDSLTRRIDYNSIAAIAADTKVDTPGAKVPRIYVPHGCPEQYEYFIECSQLNPSLNLEVKYLPDVITPEHVQSLNESPGLLALAMESHRDPITGESTLVGFPYVVPGGRFNELYGWDSYLMALGLLDCNKVDIARGMVEH... | 165 |
A9UV42 | 1.1.1.37 | ACT_SITE 185; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | ELVRVCVTGAAGQIAYSLLFSIGRGDIFGEDQPVSLQLLDIPPMLGVLEGVVMELNDCSFPLVKNIVATADPAEAFLDCDAAILVGAVPRREGMERKDLLQQNAKIFKMQGQDLDRVAKKSVKVLVVGNPSNTNAMITAQYAPSIPKSQFSCLTHLDLNRAKGFVARRLGVNPEQVKNVIIWGNHSATQYPDVSHAYVANPDGTKVKVTEAVNDDAWLHGEFVQSVQSRGGAVIKARKLSSALSAAKAISDHMHTWWFGTPDGEFTSMGVVSDGSYGTTEGIVYSFPVSVKNGQLNIVQGLSVDDFSREMMDRTDQELTQ... | 5 |
A9UYF0 | 2.3.1.48 | ACT_SITE 167; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MGNNRIAPWYFSPYPECFTTVDIMYICETCLKFSRSETTYRRHKAKCKLRHPPGTEIYRKDGIQFFELDGRKQRDYCQNLCLLSKLFLDHKTLQYDTDPFLFYVMCSLDERGSHIVGYFSKEKESEQEYNVACILTLPQYQRMGYGTILIEFSYALSQEEHKTGSPEKPLSDLGLLSYRKYWSQAIVEVLRDVKEDISINDIADRTSIKVEDIISTLQHLSMIKYYKVNLQGYLDRRLSLEHDKAMKKRRIRIDPKFLKWTPTDWTSGW | 61 |
Q5I043 | 3.4.19.12 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 605; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MTAELQQDDSAGAADGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDQRVKEPSHDTTAAEPSEVEESATSKDLLAKVIDLTHDNKDDLQAAIALSLLESPNIQADNRDLNRAHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYNLPQNILENCRSHTEKRNIMFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSHLRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQ... | 175 |
A0A2C9VGJ0 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGMEASFIFFLLVLPLVMADLRVGFYQSTCPQAESIVSQVVKYRFNTDPSLPAALLRMHFHDCFVTGCDASILIDSTKQKESEKDAQPNHTVRGYELIDAIKEAVEAACPSMVSCADIITLATRDAVALAGGPNYTVPTGRRDGLVSNIEHVKLPGPTFTVSEAFQVFKAKGLNFADMVTLLGAHTVGVAHCSFFEDRVSNFQGTGSPDPTMDSNLAANLSKICGASNTDPAVFLDQSTGFVFDNEYYKHLLLKRGILQIDQELAIDRTSIGIVSSFATNGIGFKQSFANAMVKLGSTQVIVGNAGEVRTNCRVFNVQK | 14 |
Q93VD3 | 2.7.11.1 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVV... | 99 |
A0A0R0I1Y7 | 1.11.1.7 | ACT_SITE 83; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMAGVSGSSTTPLLCSLFFISSLLFASCTHASSQAPPPIVDGLSWDFYRTSCPMLEGIVSKHLQKVFKKDNGQAPALLRIFFHDCFVQGCDGSILLDGSPNEKDQPANIGIRPEALQTIENLRSLVHKQCGRVVSCADLVVLAARDAVSLSGGPIFPVPLGRKDGLTFSIDGTGNLPGPSSRTGQLLDRFAGRNFDATDVVALSGAHTFGRAHCATFFSRINQTDPPIDPTLNNNLIKTCPSSQSPNTAVLDVRTPNVFDNKYYVNLANRQGLFTSDQDLFGDARTKGIVNSFAENQKLFFEKFSNAVVKLSQLDVLTGK... | 14 |
H2MFH9 | 2.7.11.13 | ACT_SITE 500; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000550-1" | MADGSFNESSTADVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHELVTFCCPGADKGPDTDDPRTKHKFKIHTFGSPTFCDHCGSLLYGLIHQGMKCDSCDMNVHKQCVMNVPSLCGMDHTEKRGRLLLRCEVSGDKLKVAVNEGKNLIPMDPNGLSDPYVKLKLIPDPKNETKQKTKTIRSNLNPKWNENFTFKLKPSDKDRRLSIEVWDWDRTTRNDFMGALSFGVSELMKSPAYGWYKLLCQEEGEYYNVPISVEDDGNEELRQKFELYDAQLKESCASALVCN... | 100 |
W5MR93 | 3.1.4.11 | ACT_SITE 320; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 365; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | VHMYADARGVTKQQMASSRCNLRIQGDDNLQSMLVGTVMRKIKSRTWKKQRYFKLQEDCMNIWYKSKKAGNNHSTFSVCDVETVREGHQSEVLQSIADEFPPDRCFTLVFRGRRGNLDLVADSPEEAQSWIKGMRKLIENVENMGQREKLDQWICDWFQKADKNKDGRMNFKEVQDLLKMMNVDMNEHHALRLFKMADKSHSGTLEDDEFVLFYKMLTQREDVLRLFQEYSSDGQKLSLTDLEEFLLVDQLEGDHTRQRAMELIERYEPSETAKMLHAMSIDGFLMYLCSPDGSIFNPHHEQIYQDMTQPLCHYFISSSH... | 153 |
O13310 | 2.7.11.1 | ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDKNDYLHFERNPSLFPKSTLDKVQKTKKYIEHYYKVAVDHAVERNQRRINLEQRLATERGSEERKNRQLRASGEKESQFLRFRRTRLSLEDFSTIKVIGKGAFGEVRLVQKLDTGKIYAMKSLLKTEMFKRDQLAHVKAERDLLVESDSPWVVSLYYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVLAIADVHRMGYIHRDIKPDNILIDRDGHIKLSDFGLSTGFYKQDQSASYMKPRTGNTVKRGQMVDAIWLTMSSKDKMATWKKNRRVMAYSTVGTPDYIAPEIFLQQGYGQDCDWWSLGA... | 99 |
A0A8I6WWZ5 | 1.11.1.7 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIQACWTRGATFQASPTLSLYIPPQCRYLISSTSKSPDRYLHIFPLTSSCVYLDTQDIYTHVGAEGKMAGVGMNQLVVLLLLVALHGLLPPSAHAALQDGFYSASTNCNVDVEAVVWDVVEQHVSRFGDGGSGAGLIRLHFHDCFVKGCDASVLIDPSPVNPNPEKASPANGGLRGIDVVDEAKSRLEGACPGTVSCADILAFAARDAAYILSSGAISYSVPSGRRDGLTSNAADANRNLPPPFAQLDDLVRAFASKGFSREELVVLSGAHSIGRVHCSSFRDRIHPTVNETMDWSYGTYMQWQCPEDAGTEKWIEQDIA... | 14 |
P34516 | 2.7.11.1 | ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MPGDVGEETLEIGAVVGKRYKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISKKHVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCSVAMHDRYEQGRVDDLWALVYILAEMRCRLAWHDVDDKVEIGEMKRKIHDEVLFAKSPVQMLSFVKTVRSTLFYHRPDYEKLFKLLEDVMKCANYKWSDPYHWEPEKKKNPASQGNKFGLGKK... | 99 |
Q8GVP1 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAIFVVLVAAAAAALVSSSAAQAQLKVGYYGDTCNGAEETVRQEVASVLSVAPYLAGALLRLHFHDCFVRGCDGSILLDSVAGGAVDAEKEAETSAGLRGFDVIDSIKEKLEQACPGTVSCADILALAARDAVHWSNGPFWPVPTGRLDGKISNAAETVDLPPPNSGMAQLQAAFAHKNLTAKDLVVLSGAHTIGFSHCQPFHDRLYNYTGGNRLNDVDPELDPAYLNELRSKCGAAASATANADNPGVMVEISPKRSPKFDTGYYTQVARRRGLFRSDAVLLDDDFTGAYVKKHATGLFDMEFFGDFGEAMVNMGNLQ... | 14 |
A0A9R1W2F4 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKGFCLIILGVLAILGSVEGDLEMGFYGSSCPKAEKIVQDYVNQHVPNAPSLAAALIRMHFHDCFVRGCDGSVLLNFTSASGNQTEKVAVPNQTVRGFDFIDRLKSLLEAECPGIVSCADIVALAARDSIVLTGGPSWRVPTGRRDGLMSNASEALAQIPAPFDNITILTQKFANKSLDLKDLVLLSGAHTIGISHCPSFTNRLYNFTGVGDRDPTLDSEYADNLRSRKCRIQNDTTTIVEMDPGSRKTFDLSYYALLLKRRGLFESDSALTRNSNTLTFINQLLQGSIANFYTEFGLSMEKMGQIGVKTGTTGEIRRNC... | 14 |
A7EUG8 | 1.1.1.37 | ACT_SITE 180; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MGFKAVVAGASGGIGQPLSLLLKTSSLITELALYDVVNTPGVAADLSHISSPAKITGYLPKDDGAKLAFKNADIIVIPAGIPRKPGMTRDDLFNINAGIVKGLIEIIADVAPKAYILIISNPVNSTVPIAAEVLKAKGVFDAQRLFGVTTLDVVRAETFVAEIVGKANPQELTIPVIGGHSGETIVPLFSQAKPSVEIPSDKLEALIKRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAEKVLKALNGEKGIVEPTFVYLPGVPGGDAIAKETGLDFFSVPVELGTNGADKAQNPLTNINDAEKKLLAACVEGLKGNISK... | 5 |
A0A0D1E4V4 | 3.2.2.27 | ACT_SITE 220; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MTTRTTPSKRDANTIASEVLDAIQEPTMKRVKKNGRVHEDEFDTSDQELDDEALLAATEEAESAASNYCPSSQPDPLSSQPVPATAASAEPPVATTTSSPTSTPRSSLRQTTLFPSSNGTKSLSSATTTSTTTSPLPRLEPPADISADPLWLERQTMSHDWFSLLQPEMCKPYFSQTLKSFLAAEDKSGRKTYPPRELIYSWSRLVPSPHHVRVVVVGQDPYHGPNQACGLSFSVPRGVRVPPSLKNIYKELASEYPGTFRPPDHGCLDGWARQGVLMLNACLTVSAGAANSHNGKGWEGLTKHVLKKIADEAGASSAAN... | 173 |
Q8P8W7 | 3.1.3.48 | ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1" | MRLLVVCLGNICRSPMGEGALRARLDTSPLARRMEVDSAGTGDWHAGEPPDARAIRCARGHDVDISGLRARQVQLADFERFDWLLCADASNLRNLQRLAPASLRDKVALWLPWAGVDERSDIPDPYTGGKQEFELAWRLVDTAARQTVARLTRG | 149 |
Q5B1E0 | 2.3.1.48 | ACT_SITE 657; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MPATVPTAADNSESRPTAEDFVDSDQDAEGEETDLYQMDQQLQDAVHRAYSGEIEAESGAVEVDEDMDAEGEVDYDHVPNGEIDEAEPVGAVKIPEGASSINNDNDDDADADADADADDDPEFNEQSESERGGSSSSSSRDSDEDWEAESNGPAEAEADNNTVRGNCIFCNQDEDHDPSEEFEEYLSCAVCGDHSHRQCARENNALNDAEDTGSWRCPTCHSENLEPSSKEEASSRRKSGPKNMNKELLPAHSGEEGSDFHSIFDTVTVDEELLNSSRSLRKRKTQSVDAEEHAPVLRKRLRQSPARVARADSQDQIKAN... | 61 |
G3QJ69 | 2.3.1.286 | ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAW... | 58 |
A0A067ERK3 | 3.1.1.11 | ACT_SITE 224; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTHHVAAVFTIIIFIINHLANSANGGGGDGAVIPPEKSQIGSWFTANVKPYTERKTTLDPALSTAQAGQRVIKVNQDGSGEFKTINDAINSIPQGNTKRVILSIGAGEYVEKIKIDRSKPFITFYGSPDAMPNVTFGGTAKEYGTVDSATLIVESDYFMAVNIIIANSSPRPDGKREGAQAVALRISGTKAAFYNCKIIGFQDTLCDDRGNHFFKDCHIQGTVDFIFGSGKSLYLSTELRAMGDTGLTVITAHARESESEDNGFAFVHCTIEGSGNGTYLGRAWKNSPRVVYAYTTMGNVVNRAGWSDNFRPERRQTVFY... | 125 |
A0A8V0YTR2 | 2.7.11.1 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MSGAGGRVCDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSEQQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQPLNRSLAIELLDKMNNPDHSTYHDFDDDDPEPLVVPHRIHS... | 99 |
O35655 | 3.1.3.16 | ACT_SITE 237; /note="Proton donor"; /evidence="ECO:0000250" | MGCGTSSKKGNKSKKVIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQLSSFFSFMLENYTKTNNEDSALVTRIFDNTRRESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQ... | 144 |
Q8Y4G7 | 5.1.3.3 | ACT_SITE 182; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 317; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MIFIEVMKERFGEFEGETVWKWTMINDHDMRMSVLNYGAIVTSLETKDKFGDFANISLGFTNLDDYLAHSPYFGATLGPVAGRITNGQFSLDGKQFQLIQNEGSNHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGKIDAKMTYTLNNKNEWLVDYEARSNQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEITQSQDQQVKLVGAGLDHTFILKHENGRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIDERAVPKYAGITMETQG... | 211 |
B9S1U5 | 2.1.1.37 | ACT_SITE 350; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MNKFYGNDLHYDQLLQGEGGQKHVGRIVEFFKTTDGEDYFRVQWFYRAEDTVIKEEAGFHDKKRLFYSTIMNDNPIDCIISKVRIVQLPSMIGSKSSIRSTDFYFDMEYNVDYSSFRTLLIGKHFCLRDNSSSPNVVEAVSTTGGNTSLENMRSSESNKAELALLDLFSGCGGMSTGLCLGAKVSCVDLVTRWALDSNKSACESLKLNHPETNVRNEAAEDFLELLKVWEKLCKRYAVKDIKSMQQSRSIASRVAEENDNSLSDNDITPGEYEVSKLVDLCYGDPDNIGKRGLKFKVHWKGYSTSEDTWEPVEGLRNCQE... | 47 |
A9WEM2 | 1.8.1.4 | ACT_SITE 448; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MSEQVYDLVVLGSGPGGYVAAIRAAQLGMKTAIVEVNALGGVCLNIGCIPTKALLHSADLLEEVKEAKRFGITVENVAFELAGAMKHKDTVVKQSTDGVAFLMKKNKIEVVAGRGRLIGRGQVHVQLNEGGERVLAAKHIIVATGGRPRPFPGIPFDGERVLSSTDMLTLKTVPSSLLAIGAGAIGVEFASMFRSFGSDVTIVEALPRIVPNEDEEVSAELTKAFQRRGIKTLAGAKVEGVDVGGEKVVVTVVDSSGKPQQIAVEKLLVSIGIAPNTENIGLEEVGVKVNNRGFIETDGFLRTSAEGVYAIGDCTANTPW... | 36 |
Q9UTE4 | 3.5.1.2 | ACT_SITE 101; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P37528"; ACT_SITE 208; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P37528"; ACT_SITE 210; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P37528" | MSSASMFGSLKTNAVDESQLKARIGVLALQGAFIEHINIMNSIDGVISFPVKTAKDCENIDGLIIPGGESTTIGKLINIDEKLRDRLEHLVDQGLPIWGTCAGMILLSKKSRGGKFPDPYLLRAMDIEVTRNYFGPQTMSFTTDITVTESMQFEATEPLHSFSATFIRAPVASTILSDDINVLATIVHEGNKEIVAVEQGPFLGTSFHPELTADNRWHEWWVKERVLPLKEKKD | 181 |
P18475 | 2.7.10.1 | ACT_SITE 741; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MLIFYAKYAFIFWFFVGSNQGEMLLMDKISHDKTLLNVTACTQNCLEKGQMDFRSCLKDCRINGTFPGALRKVQENYQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARP... | 97 |
H9G7G6 | 1.11.1.24 | ACT_SITE 51; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MSTGNVQIGKSVPDFQATAVVDGAIKELKMSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRVEEFRKINCEVIAASVDSQFTHLAWINTARKDGGLGSMNIPLVSDVSHNISKTFGVLKEDEGIAYRGLFIIDAKGIVRQITINDLPVGRSVDEALRLVQAFQFTDQHGEVCPAGWQPGGDTIKPTVKDSKMFFAKQQ | 12 |
A0A251NDS7 | 3.1.1.11 | ACT_SITE 390; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKRSRNCIKMNMLMFFPSLTSLLLMASFFFFHLGFSFSHQIPHPTIKNACTTLLHPSLCFTALASAKTHDHFTAFHHLLEANINQTVASVESTRQSIKGLLKLQDLYLQERNALKDCLEMLDQTLYELGQAVDDLHGFRVSYGNLKTLLSAAMTNENTCIDGFFELEEFDSENQIGLNGHLQGLLAPISELMSDCLAMIRYQEQALNEQKRLVTKKPKKRFPVWMLPGDRNLMQREPTMKADIVVAADGNGDYETIGEALKMAPNMSRTRFVIKIKAGVYNETVEISREKANIMLVGDGMNTTIITGSKSFADGFSTFAT... | 125 |
Q89K52 | 3.4.21.89 | ACT_SITE 44; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 105; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MSVTSGTKTESGVGETIRVVIHALLIALVIRTFLFQPFNIPSGSMKATLLVGDYLFVSKYSYGYSHYSIPFSPPLFSGRLWGSDPNRGDIVVFRLPKDDSTDYIKRVIGLPGDRVQMKDGLLYINDTPVERQRMSEYVGEDPCGSEGGGISRVKRWKETLPNGVSYETLDCADNGYMDTTNVYTVPAGHFFMMGDNRDNSTDSRFLGQVGYVPQENLIGRAQMIFFSIAEGEHAWMFWRWPWAVRWNRFFKIVR | 178 |
A0A8V0ZD93 | 3.2.1.52 | ACT_SITE 322; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MAAVAIAARALLLLAAVGPAAALWPQPQLQRSPPAPARCPLPPARFHFAHAAGSAVGPGCAVLDEAFQRYRALIFSAARPAENKQPWRTSCTELLVSVATPGCNGFPSLDSKESYKLNISRDSMLLYADAVWGALRGLETFSQLVGRDENGMYYINETEIVDFPRFPHRGLLLDTSRHYLPLKAILETLDVMAYNKLNVFHWHIVDDPSFPYESFTFPELSKQGAFNAMTHVYTASDVQTVIEYARLRGIRVIAEFDTPGHTLSWGPGAPGLLTPCYLGKDPSGTYGPINPIFNTTYQFVTSLFQEISSVFPDHFIHLGG... | 170 |
E9GLH3 | 3.4.19.12 | ACT_SITE 17; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 119; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 134; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MKTKPNIYHEKQSRQLCALHTLNNLFQKSDTFTKALLDDLCLQLTPNSWINPHRSIFGLGNYDVNVVMAAVQLMDCEMVWWDKRRKITPHEVNSAVGLILNLPSPSKVGGLLFPFKTKHWLAIRQFDSVYYNLDSKLSSPETIGDVQQLIEHLTRHLDEDDCELFLVNSTKPCTLAVAEQM | 175 |
P00334 | 1.1.1.1 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000269|PubMed:15581900" | MSFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKHWDSGI | 1 |
A9PFF1 | 4.1.1.50 | ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAQPVSAIGFEGFEKRLEICFLEPGFFSDPEGKGLRSLSKAQLDEILKPAECTIVDSLSNDEVDSYVLSESSLFVYPYKVIIKTCGTTKLLLSIPVILELADALSLTVCSVRYTRGSFICPGAQPFPHRNFCEEVTVLDGHFSKFGLESVAYVMGSPNSTQKWHVYSAAAGMKSHSGPVYTLEMCMTGLDRKRASVFYKTHASSATVMTEDSGIRKILPQSEICDFDFDPCGYSMNAIEGSAISTIHVTPEDGFSYASFEAVGYDFQDLNLRQLLYRVLVCFEPTEFSIALHSNVECDELGAMFSLDVKGYSCGGGNYEM... | 196 |
Q54YZ5 | 2.7.11.1 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNEIIVGEYKIHSLLKSFADKDEERNVYIVLNKSNEKFICKEIIYTQNSNIDNEKRKSEYINLKKFSDTIKYPHLNISKYIEHFIILENQQEKEKIKKQYIITEFYDGGDLSSLKITNKKCFSIKNGDIIYLFLKMLIIFKEFQTVIIHRDIKPDGSIVNDYYLCDLGSSTQVKTINSSTLIGTNQYIAPDVIKRGGYTGTIDIYGLGKTLLLLLNRVQQNQYNKINKILFEMMCSNESTERPTVDQLIEFMVCQYDNISFTEFDDFTHPLSKDCIEYFKNNKLNILKKDVKPIQIKIKIKEKEYRAYGAIQALLRNFYY... | 99 |
C3XQ23 | 4.2.1.11 | ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 344; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSGISKIHARQIFDSRGNPTVEVDLVTSKGLFRAAVPSGASTGIYEALELRDKDPSKYLGKGVSKAVSNINDVIAPAVIQKNFDVTKQEEVDKFMLELDGTENKSKLGANAILGVSLAAAKAGAAHKGVPLYRHLADLAGNTDVILPVPAFNVINGGSHAGNKLAMQEFMILPTGASSFREAMQMGCEVYHNLKSIIKKKYGQDATNVGDEGGFAPNILENKEALNLLMDAIKAAGYEGRIKIGMDVAASEFHRDKKYDLDFKSPDDPSRYITGDQLAQLYHEMIAAAPIVSIEDTFDQDDWEMWAKFTGQTDIQIVGDD... | 200 |
A0A9K3IQE5 | 3.1.1.11 | ACT_SITE 441; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHTHSKHIHLSLERQTNIRIMANKVVMSVASAIIVIGVVVGICLVLANTNKSHDDSHDHKVSSNSKTAETICKQTEYQDTCLDAVDEVAKNSSATPQDYIIAVIRATADELNKSLEKATAAKKDCSNHTQAQLETCEKMIGYATDELKQVLKVIAETKATTLAQQADPLLDWLTAVRSYQTTCVDEIQDKKMKADMQEALQTSNELTYNAQKIVYNVHNVLKDAGVSLDAFKLPPIGNRKLLAELDEIDRNGFPSWVPKNDRKLLQATPDNEALFKTRTPPPVPANPTPDAVVAQDGSGRFNSIKQAVAAYAPGPSGRYI... | 125 |
A0A0A0KBB7 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASSSQKFKLLSKLLSNCIIFFFLFHSTLASKTLKVGFYKSSCPHAETIIKNAVNQAISQNPGIAAGLIRMHFHDCFVRGCEASVLLKSTPNNPSEREHIANFPSLRGFEVIDEAKAKIEAICPNTVSCADILAFAARDSACRVGGINYAVPAGRRDGRISIKEEANSLPGPSFNAEQLTESFGKRGFSSEEMVTLSGAHSIGVAHCPTFSNRLYSFNTTHPQDPSMDPLYAAYLKTKCPPPSGNNDGSDEPTAALEFFSPHRLDNWYYIELKNHRGLLSSDQTLLSSSSTKEMVLHNAKHGHQWAAKFGKAMVKMGFVD... | 14 |
Q747F9 | 6.3.4.4 | ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MANVVVVGAQWGDEGKGKVVDIYTEHADDVVRYQGGNNAGHTLVVGEEKVVLHLIPSGILHEGKRCIIGNGVVLDPEVFIQEITRLKDKGRLKDDRALLVSESIHIIMPYHKRIDIAREAKSGEKKIGTTGRGIGPTYEDKIGRRGIRLMDLLDRDVFARKLKENLEEKNVILEKLLGDKPFTFEEIYEQYCGYADILRNYVADTSLILYNDSKAGKKLLFEGAQGTLLDVDHGTYPFVTSSSTCAGGACTGTGVSPRDIHEIIGISKAYVTRVGSGPFPTELLDADGEKLRQVGHEFGATTGRPRRCGWFDAMVVRYAV... | 253 |
Q10407 | 2.7.11.25 | ACT_SITE 955; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAADIGSQSSGSLEERFEQSLHLQNVDKQDWSLNSVLQFLKLYKFNKEWEDVFIKSRIEMDLFINLADQSKAEEFAFKNKLSKESAIQLSSCIRKTLLAPSSTRVPSKNSSYETLTYSAKDSSDDVFTETNSGFRSSNQNSSLKSFQSVPDSNVNVFGGFGGSVVDNNELLSTGKNSHQTTSLNLEGSPINLHAYKGTVTSIINDDSRNINKKTLSKQPVSEHKEKQTSFLRRFRVPGFSRDKDKTKDCPSSNSNPFHLASSNVKTLDASLDQGEWVPRIHRLESQIGLISKKKSFVLATMDDMKFTVVDITNVQNATQL... | 105 |
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