Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
B9GXZ7
3.1.1.11
ACT_SITE 430; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MDSINSFKGYGKVDEAEQQAFRKKSRKRLIIIVVSSIVLLAVIIGAVIGAVVHKRNNKSSSNPVPPPELTPATSLKAVCSVTQYPASCFSSISALETGNTTDPEVLFKLSLRVAMNELSKLKDYPDKLIQSIKDTTLQGALKVCATVFDDAVDRLNDSISSMAIGEGEQILSPAKMNDLKTWLSATITDQETCLDALQELSTTKHFNQTLVDQVKTAMENSTEFVSNSLAIVAKILGLLSDFKIPIHRRLLGFERSHISEFPQWVSFGDRRLLQESKPTPNVTVAKDGSGDCETLREAVGKIPKKSESKFIIHVKEGVYVENVILDKSKWNVMIYGEGKDKTIVSGSLNFVDGTPTFSTPTFAVAGKGFFARDMKFINTAGAEKHQAVAFRSGSDMSVFYRCAFDAFQDTLYAHSNRQFYRDCDITGTIDFIFGNAAVVFQNCNIQPRQPLANQFNTITAQGKKDPNQNTGISIQKCKFSAFDNVTAPTYLGRPWKDYSTTVIMQSDIGSFLRPLGWISWVSGVDPPATIFYAEYQNTGSGANVDGRVKWTGYKPALTVDEAGKFAVDSFIQGSEWLPKTSVTFQSML
125
P9WI73
2.7.11.1
ACT_SITE 276; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
99
B7PDB8
2.4.1.18
ACT_SITE 337; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 392; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MEVPEIGNLLDLDPYLKNYEQEIRRRYKCFSDRLTEIENVEGLLRFCKSYEEYGIHCLPDNSVRIREWAPGAEALFLRGDFNGWERLTHPFKKLPFGKWELTLPPKPDGSCPIDHLSRIKIVVLDRTTGQLADRNSPWATYVVRGKDAPQYEQRLWNPPPEERHQWKHPKVAAPQSLRIYECHVGIASEDYWVANYSYFTSHVLPRIKAQGYNAIQIMAIMEHAYYASFGYQVTSFFAASSRYGTPEELKALVDAAHGMGLYVLLDIVHSHASKNVLDGLNRFDGTDACFFHNGGRGHHPLWDSRLFDYTKLEVLRFLLSNVNWYLTEYRFDGLRFDGVTSMLYHSHGMGHGFSGDYNEYFGLNVDTESLVYLMLANHVVHKLHPTAITIAEALVGDKTLAFWLMDKEMYTHMSTLTPLTPVVDRGLAMHKLIRLLTHALGGEAWLNFIGNEFGHPEWLDFPRAGNDESYHHARRQWHLVEDDLLRYKFLNRFDSALNHLEEQHHWLPSPPHEDDKVIAFERAGLLFVIGLHPCKSFTDYQLGIDVPGEYRIVLDTDAEEFGGHRRIDHSVRCFTFDQPYAGRRHSIKVRPFDSWELLGGGSV
73
A8WWX1
2.7.11.25
ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:O43318, ECO:0000255|PROSITE-ProRule:PRU00159"
MDTSPHSKPSSSSASQSSHSPSPAPVTAPRKTRDSGLCMTQDIPEIPTHCIDNLNSHQLGRGTYGIVEKTRYRRSRNHEYRPAAIKYSSPIHLATLIREAKVMWALRDHSNIIKIYGLYRDARHGQGVVMEYMDCGSMSELIYDRKSIDYTIDHVASWLYQMASAVNTFHRNDQVHRDLKLQNMLLCDRYRTMKLCDFGTFTAMHQSMTSNRGTPITMAPEVFRCEEYNQKSDIYSIGIIMWQMIARNHPYNRNLSVPGLLYNVATASLRPPELDCNPILSDFYKQCWHDDPVSRPTAAECLQYFTALKTEYPNGNVPLADANTNRPVETPPPRVHRPSGLGSASGSGLGTNGRTPTASNHLNAPQAVNTHRRNRSETIQMKPELPYPVMPGEVAASSSGAFRGPRSQSEAKNLRDAGRSQSGQRHPHRNAPPIPIDDRRDSNESNEKDAIFMELLRNDDTRPVDPDARDEASLDIFHQHCSSNKEYADALLLKKEVLRAKHELLSRWPQHQRHVELLERQNYLEQEIAKLEYNSDDDFSITERL
105
K7LFL7
3.1.1.11
ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTMMGKTLLLTLLLLSSVFSIASSRRRHSNNSNIDWWCNQTPYPEPCRYYIKHSHYQHKQLKHKSEFRTILVHLALERAVIMRRKARELGGNGVTKKQKSVFRDCLKLYDNTVFHLNRTLEGLHVKTSCSPFDAQTWLSTARTNIETCQNWALELGIRDSMVPAERCNLTEIISNGLFVNWAFLKYREAHYTADAEEDALFPRWFSMHERKLLQSSSIRAHLVVAKDGSGHFRSVQAAINAAARRRLKSRFIIHVKRGVYRENIEVDKTNDNVMLVGDGMRNTIITSARSVQAGYTTYSSATAGIDGLHFIARDITFRNTAGPLRGQAVALRSASDLSVFYRCAIEGYQDTLMVHAQRQFYRGCYIYGTVDFIFGNAAVVFQNCVILVRKPLNGQANMITAQGRDDPFQNTGFSIHNSQIRAAPDLRPIVGKFNTFLGRPWQRYSRVVVMKSFLDSLVSPRGWSPWGDSNFALNTLYYGEYRNFGPGSSTRNRVRWPGFHRISSPAEASRFTVANLLAGRTWLPATGVPFTSGL
125
A0A078IT96
1.11.1.6
ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 175; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MELTLFNHYSTQSNPINANDSVSSISLCWFLEVLWRFIYVITYRPASSYNSPFFTTNSGAPVWNNNSSMTVGPRGPILLEDYHLVEKLANFDRERIPERVVHARGASAKGFFEVTHDISNLTCADFLRAPGVQTPLIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNIPVFFIRDGMKFPDMVHALKPNPKSHIQENWRVMDFFSHHPESLNMFTFLFDDIGIPQDYRHMEGSGVNTYMLINKSGKAHYSLLEEDAVRNIDNFFAENEQLAFCPAIIVPGIYYSDDKLLQTRVFSYADTQRHRLGPNYLQLPVNSPKCSHHNNHHEGFMNFMHRDEEVNYFPSRYDPVRHAEKYPTPPAVCSGKRERCVIEKENNFKEPGERYRSFTPERLERFIGRWIDALSDPRITHEIRSIWISYWSQADKSLGQKLASRLNVRPNI
13
A0A059B4H6
1.11.1.7
ACT_SITE 42; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
PLKVGFYQKKCPSAEAMVRESVQKALAADPGAVAPLIRLHFHDCFVRGCDGSILLNSTKGNTAEKDSMGNLGIGGFEVIDDAKAKIEAQCPNTVSCADIVAFAARDGVRAAGGLHYAVPSGRRDGRVSLASEVIQNLPGAFFDAAQLKANFAKKGLSLRNMVTLSGAHSIGDSHCSQFTKRLYSFNSTYSQDPSLNPNYAHLLKTKCPRNSPTDPIVPFDPVTPNVLDNAYYRNLKSDKGLLYSDQVLWDAPLTRGLVKDNANHPSAWARRFTAAMVRMGSIEVLTGTQGEIRKNCRVIN
14
M4D3N5
2.7.1.11
ACT_SITE 282; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MDSYRFIKSSSKQSTSSETDHHHHQFGSLIPRLGRKYRSLSFDSGLLLIVNQRFESPTRLVMATSALNSDKKIVTGPAGYVLEDVPHFSDYIPNPPTYPNPLQDNAAYSVVKQYFVDEDDTVPQKIVVHPDSPRGTHFRRAGPRQRVYFDSDDVVACIVTCGGLCPGLNTVIREIVCGLSYMYGVKKILGIEGGYRGFYARNTIDLDLKTVNDIHKRGGTILGTSRGGHDTTKIVDSIQDRGINQVYIIGGDGSQKGAAVIFEEIRRRGLKVAVAGIPKTIDNDIPIIDRSFGFDTAVEEAQRAINAAHVEATSFENGIGLVKLMGRYSGFIAMYATLASRDVDCCLIPESPFFLEGKGGLFEFIGKRLKENGHMVIVIAEGAGQDLLAESNEQSTTLKDASGNKLLQDVGLWISQRIKDHFAKKMTLNLKYIDPTYMIRAVPSNASDNVCCTLLAQSAVHGVMAGYNGFTVGLVNGRHTYIPFYRITEKQNKVVITDRMWARLLSSTNQPSFMKHDDIHEPNHSGGEAGAMNW
84
B7PPL7
3.4.25.1
ACT_SITE 25; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1"
MNAFNCPDLSDVVPDFLKAEHSTGTSTIAVEFDGGVVLGADSRTTTGYVVQPTCILGRQCDFCISCRTESLKDNALLFDILNYFAECNRHLSRMELGEPPQVETAASVFRELCYNYRDQLLAGIICAGWDRKKGGQVYVIPLGGMMLRQPVAMGGSGSTYVYGYVDAHFKKGMTKEECLEFVTNTLGLAMYRDGSSGGVIRLAVITKDGVERKVLTGDEIPKFYQD
180
Q81JD0
5.6.2.2
ACT_SITE 125; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897"
MMSDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIVLPARFPNLLVNGTTGIAVGMATNIPPHQLGEVIDGVLALSHNPDITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRGSIMLRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRNGMRIVMEVRRDANANVLLNNLYKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRSSKTADIAKQGLMERFGLSEKQAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERFNDKRRTEITIGGMEFIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILFFTNKGKVYRTKGYEIPEYSRTAKGLPIINLLGVDKGEWINAIIPIREFGDDQFLFFTTKQGVSKRTPLSSFANIRTNGLIAISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGDEDQVVGMEIVEEDVNVLIVTKNGYGKRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQISQMGRNTQGVRLIRLEEDQEVATVAKAQKDEEEETSEEVSSEE
222
O86776
5.4.99.12
ACT_SITE 63; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MSDEVEAGFVRVRLDLSYDGSEFSGWAKQAGGRRTVQGEIEDALRTVTRSRETYELTVAGRTDAGVHARGQVAHVDLPREVWAEHHVKLLKRLAGRLPRDVRVWALREAPSGFNARFSAVWRRYAYRVTDNPGGVDPLLRGHVLWHDWPLDVDAMNAAARGLLGEHDFAAYCKKREGATTIRTLQELSLVRGEDGIVTATVRADAFCHNMVRSLIGALLFVGDGHRGPEWPAKVLAAGVRDSAVHVVRPHGLTLEEVGYPADELLAARNKEARNKRSLPGAGCC
217
I3KFN7
3.5.1.98
ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
SGDIAFRMTNRTSYFYDPDVGNFHYGAGHPMKPHRLSLTHSLVLHYGLYKKMMVFKPYKASQHDMCRFHSEDYIDFLQKVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNHKICDIAINWAGGLHHAKKFEASGFCYVNDIVISILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYRQLFQPVIKQVVDYYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEFVKSFRIPLLVLGGGGYTVRNVYFEYFAPDFTLHPDVSTRIENQNSRQYLEQIRQTVFENLKMLNHAPSVQIHDVPSDMLSYERNDEPDPDERGAEENYTRSARASNTRRATSRHRNEADQKKNAGGKVKVV
184
E9HG29
3.5.4.5
ACT_SITE 69; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MGDCDEEVDFDLLDPAIQKIINKAKAVREKAYCPYSKFAVGAALLCDDGAIIDGCNVENVSYGLTICAERSAICKAMSEGQKVFNSIAICAEMKDKFVGPCGACRQVLAEFNVNLDVYLCKPNNEILKTSMAKLLPLSFTPNWVSFSS
187
A0A1S3YI46
2.7.1.11
ACT_SITE 310; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MESLSPAIGQKAILRYTTTYSYHDLFLSSVRLRTVRNPNRVSRRLRIRVQAKSGAFENSAAGGGCIDFSDPNWKLKYQREFEARFNIPHITDVFPDAVEYPSTFCLKMRTPVSEEFAEGYPSDEKWHGYINNNDRVLLKVINYSSPTSAGAECIDPNCSWVEQWVHRAGPREKIYFKPEEVKAAIVTCGGLCPGLNDVIRHIVITLEIYGVKKIVGIPFGYRGFSEKDLAEMPLSRKVVQNIHLSGGSLLGVSRGGPKVSDIVDSIQERGINMLFVLGGNGTHAGANAIHDECRKRRMKVAVVGVPKTIDNDIMLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIGIVKLMGRSSGFIAMQASLASGQIDICLIPEVPFNLHGPHGVLRHLKYLLETKGSAVVCAAEGAGQDFLEKTNAKDASGNAVLGDIGVYLQQEIKKYFKEMGETSDVKYIDPTYMIRACRANASDGILCTVLGQNAVHGAFAGYSGITVGICNTHYVYFPIPEVISKPRVVDPNSRMWHRCLTSTGQPDFL
84
O94324
2.7.11.1
ACT_SITE 652; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTNPEQLKRILSHEVLLKIEMSKNGIVEYANPAFFELIGYEGDLFQCSFYEYLQSDDEHLMKKATDNLFRKSISVAHVFAFLRCNPIRSPNYYIQQAKAPFEGKTYIRMLFRGILVDSLYGKDTRVLWAGKYLYPQRSVINEMDFILFNTLGIGAFILHDHLLGIIKYNYIHVPPPSGKLCSLCEDNLPEWYFEVHSDFCLVWNDLVRRVFAVQQLINCKKLEIEDIVNKLPTGSNHMVEETFLSLPVITVFNGKKNRKQRFRIRSWRSSLNFLVKELDKSIKNFAYLEHRTFLTISNSAAKDMKREIYEKSLVNWEYDFLVPSKIQDYFYDVHSLLLKNLSSKIKLCNHILMYQATFNEVKNFLQTYSLNMLSIEMENIEGSLYFGNAQLSNLICVNQYLSEQRPVFFNRLLALGNVENNNSIYDDIQKRTERISTIKRHKKYFEIGERLTEKDLIVSKTFKTTRIDYFKAVKGSIEDLDVRPLKNRQKFVNKFYASIVHFLTESMQFPSHNDRRFGDNTPHSLDEFILLKEINRGAYGRVYLAKKRSSGKYFALKMIPKSSLDSLKKIKGLLLEKRNMHIQRYGPNTVKLYYAFDSGDYLCLVMDYFNGGDCETLIQKLGPLPEQWVCQYAAELLNAIELLHQDGIIHHDIKPANMLVDETGHIRLTDFGLSENVEEKKEVYKLTKRMSFEQKHGNLYEQLQPKKFEFVRYVRNYRGNIDELEKAESPQQNSDYANDSVQHLLDFDINNMDETAIHMLMNQLEKKENRTFIKKDISGTPNYMAPEILMGVDTQMGDIWAMGCVIFEMLTGTRPFEANTVKAIWARIERNDIGWTKRVKESCSKEAVDLITKLMDPDCNKRLGSNGYQEIKKHPFFRTIKWDNLNSGPGPFVPQTENVEDLTYFEKNISGSDNINKNNCQTSATLILNGIFAFHPPPKATPADSGTETSNSAAFSASEEETTNLTDQKRKDLFSLITKAFKGIDLKALNYNNKATLLRMYDEVDFPKNQQRNKEKFRIQKRPNKKYRYHLF
99
A0A0D1E476
6.2.1.5
ACT_SITE 283; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1"
MFKHAAASLSRPLARGFSSSAARASYEDTIKNLLINKDSRVICQGFTGKTGTFHCQQALEYGTKLVGGVSPKKAGQTHLGLPVFGSVKEAVRETKPHASVLYVPPPGAADAIIEAIENEVPLIVAITEGIPQKDEIRVAAALRSQSKSRLVGPNCPGIINPEGCKIGIMPGHIHTPGRIGIVSRSGTLTYEAVNQTTQVGLGQSLCVGIGGDPFPGSTTLDLVKLLLDHDKSEGIVLIGEIGGSMEEDAAEYLAKYNKTRANPKPVVAFIAGRTAPPGRRMGHAGAIIAGGKGGADDKVKALTEAGAIVADSPAKIGALMKQAMQNAGLA
247
A0DMT8
2.7.11.1
ACT_SITE 277; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MNYPYQPYRPYQRLPNSSVHNPNIMSYVDQVLSKSRTNYGSVQQDQQPKYQTYQTNSIKTDTDLKSIGNSPLILPQKSLVIQPTLKSKQEYLFPKKVESLSFQSDIPPIIPLIPLMSDVREQYTKKQVSTPISQASSPMKKPENQKQKYKNFTIIKKLGDGQYSEVFVAKHTQTGFLVALKVIQKSQIIKENMQAQLAWEIKIQYLLEHPNITKLYTFFQTPTEIVLVLEYCSHGQLNTLQQMQPMKKFQERVAAQYVQQITFALMYIHNQDVIHRDIKPDNILLSFGQVKLADFSFCVYSPDEERQTQCGTIIYASPQILEGETYDKKSDIWGLGVLTYELCFGKPPWKENQQELMKTACFMIPFTASRELKDFIENLMKRLSRDRFTAQQAYNHAWLQRIAQIVPYYITNNETLFL
99
A0A380PL54
3.1.3.3
ACT_SITE 117; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 119; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MSNSLTYCDLPSEIYQWPGLPLSLSGDEVMPLDYRAGHTGWLLYGRKLDKQRITDFQRQLGAAMVIVSAWCVEDYQVIRLAGSLTPRIKTLADESGLDVAPLGAIPHLRTPGLLVMDMDSTAIQIECIDEIAKLAGVGDEVAAVTERAMQGELDFSASLRQRVAALKGADANILKQVRDDLPLMPGLVSLVRKLQALDWHVAIASGGFTYYAEYLRDKLRLVHVAANELEIKDGKLTGCVLGPIVDAQYKADTLIKLAEKLNIPLAQTIAIGDGANDLKMMQVAGLGLAFHAKPKVYAKAKVAIRHGDLLSVLCILTGSLKHESGK
147
Q9HQS4
5.3.1.1
ACT_SITE 85; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"
MFVLVNLKAYPCDPVAIAEAAADVAETTPATIAVAPQPADIGRVADTGATTYAQHVSPTEHGSHTGSVLAESVADNGAVGTLLNHSEHRRRLADIDGSVAAAERAGLDTVVCANNPAQVAAAAALGPDAVAVEPPALIGTGTPVSQADPDIVSDAVAAAEAVDPSVDVYCGAGITTGEDVVSAGDLGASGVLLASGVAKADDPRAALADLVAPL
213
A0A7M7PPY0
2.3.2.26
ACT_SITE 766; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MPSISQVFTMPNPSVRREGPMKLRLTVLCAKNISKKDFFRLPDPFAKVVVDGSGQCHSTDYCKGTLDPKWNQHYDLFLSLSDSITLSVWNHRKIHKKQGAGFLGCVKILSHAIQRLKDTGYQRLDLCKHKPEDGDNIRGQIVISLTSRDRVGSSASGAVVDSRNINPHPMLPSDPNELPDGWEERMSTSGRVYYVNHLTRTTQWDRPTRPAVECTQSQAPSSRTSTHANGHHNNHHHHSSTSSTSSQPHHRGTSHGDRGGGGGGSGEGHEGVRPGASSRHGGPAPSEEQNKYTRRATSRMRNYMNRSTLHRVIDLPEGYEQRTTAQGQVYFLDTSSGDSTWHDPRLPRDLHINEADLGGLPPGWETRHTATGRVYYVDHNNRTTQFTDPRLDAQIINRAMSKQNGNTDSSPVPKYKRDLVQKMKLLHAELATVQPQTGHCRIEVGRENIFEESYRQIMKLKPKDLRKRLAIKFKSEEGLDYGGITREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSGVNPEHLSYFHFVGRVIGLAIFHGHYIDGGFTMPFYKQLLGKPVSLEDMETVDPEVYRSLVWILENDITGILENTFAVEHNSFGQMQIHELKPNGIDIPVTEENKKKYVKLFVQWRFLRGIEPQFLALQKGFHELIPPRLLKPFDERELELLINGLGKIDVEDWKNNTRLKNCSLETAIVQWFWQAVDSFDEEKRARLLQFVTGTSKVPLEGFKALQGSTGALSPRLFTIHQIDANTDLLPKAHTCFNRLDLPPYENYSKFFDKLTCAIEETCGFTGE
65
Q20296
3.5.1.98
ACT_SITE 146; /note="1"; /evidence="ECO:0000250"; ACT_SITE 561; /note="2"; /evidence="ECO:0000250"
MLFEDRQKNRSTGPTLIGFNQTQNEHENTVCPTHPESSDRILKIKEALTKTKILEKCTVLTNFLEIDDADLEVTHDKSMVKDLMESEKKTQEDINSQCEKYDSVFMTENSMKVAKDGVACVRDLTNRIMANEASNGFAVVRPPGHHADSVSPCGFCLFNNVAQAAEEAFFSGAERILIVDLDVHHGHGTQRIFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSIIFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVLEGGYNHQISAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLRHHWNCFDYFPSRTSLRLAQWPIVNTKVIYNYDPTTRRADTGEIIQDELASTEFTASDVIPTENMETLIYFNEGDDAHFDLEEDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMKDEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPGHHASASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYEDSNVMYMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQRVIMPIAYQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSISNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWSILKGFQVTPSNYGLDIDDEAYDDDSIDMADQSSSSGSSSSSTRPSHNLEIMDSGPAHAVVPLATCPHLKEVKPLPPAKINARTACSECQIGAEVWTCLTCYKYNCGRFVNEHAMMHHLSSSHPMALSMADLSVWCYPCDSYVHNPALIGAKSAAHESKFGETMPS
184
B9RR23
3.1.1.11
ACT_SITE 382; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAFSLLNLLLLLFFFSPIFFSSAWAANISSSSSANSLDTHLSSLRNFCSGRPYPDACFDSLKLSISINISPNILNYILQTLQTAISEAGKLTNLFSSAGSSSNIIQKQRGTIQDCKELHEITLSSLKRSVSRIQAGDSQKLADARAYLSAALTNKNTCLEGLDSASGPLKPVLVNSVISTYKHVSNSISMIPSPNSEKGQKNRRLLGFPKWLSKKDRRILQSDDGDEYDPSEVLVVAADGTGSFTTITDAINFAPKNSFDRIIISVKEGVYEENVEIPSYKTNIVLIGDGSDVTFITGNRSVDDGWTTFRSATLAVSGEGFLARDITIENTAGAQKHQAVALRINADLAAMYRCTINGYQDTLYVHSFRQFYRECDIYGTIDYIFGNAAVVFQACNIVSKMPLPGQFTVITAQSREIPEEDTGISIQNCSILATEDLYSNASSVKSYLGRPWRTYSRTVILESYIDDFINPTGWIEWPGNQGLDTLYYGEYDNYGPGSATDNRVTWQGYHVMDYYDAFNFTVSYFITGDEWLDSTSFPYDDSI
125
A0A3Q7GMX0
1.11.1.7
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MDSKGFNCSVFVLVCCLVLSLSVSSLAKRQPSCLIEVGYYRYTCPSAEAIVRKVVYKAVARNPGIAAGLIRLHFHDCFVRGCDASVLLDGLNSEKESIANKNSLRGFEVIDEAKKQLEAACPGTVSCADILAFAARDSSYKVGKINYDVQAGRRDGHVSIKDEALANLPSPFVGVKELIKSFARKGMSVDEMVTLSGAHSIGVAHCAVFANRLYPQNKQQNLPIDRVYERMLKSICPPESLTNGTGVANPTNFDVITPNKLDNKYYMDLKSNKGLLVTDQTLMSDPKTAKMVNFNARYGRVWGKKFADAMVHMGTLDVLTGYKGEIRKNCHFVN
14
B3RY08
2.7.12.1
ACT_SITE 450; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
VASSSDFLFKLAVFSYKVLHWNLSNLTALLNLTSTRYLKMLHVYTLDMSRYMKITPKRVRYVKDHERKLYSCLLEITSEKEKEFNEAINEAVQGWSSSIVEKVINVEIPNDFLNKDNKPKTWVQLQHITKFVEKIVYDELYKKISSKIVASIKLLQESFTGTLKRCVEHLEVNNNNQPADHEVIRASRALKEFLDVAYEVDMPVSHTTSIIKVVLDEIKSTFKSIRRGDLPVIDKKWKSNIALEALQSINISQFTKQASNHLKQRIKKSHETFTAALTMLENRHRTRITTTEERLSEVRTYYAPTLARLSLTSTSLYHLCKYGIPQRGRELGRGQYGVVYAVQGSWAGHARCCLKSVVPPDDRHFNDLALEFHYARNLPHHERIVSFYGSVIDGSYSSHKVAVCLVIERLHRDLHSGIRRGLTIDQRLQVAVDVISGIRFLHSQGLIHRDIKLKNVLLDKSNRAKISDLGFCKPESMINGSIVGTPIHMAPEVFDGKYESSVDIYAFGILFWYLCAGKVTLPDAYNNFKRKTDLWRFVASGGRPEKLQFFSDDCWNLMTLCWSEKQEHRPLPGVVAKKLDEIVSNK
107
F6HSM4
3.4.21.92
ACT_SITE 160; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 185; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MERSLTLTYAASASRPLCFNRSPSSSSLWLPSTSRSSRKGRAVSMVKASSASRPTLASNWDLSSLQSASAPTWLPRFEDLDTTNMLLRQRIVFLGSQVDDMTADLVISQLLFLDAEDQEKDIKLFINSPGGSVTAGLGIYDAMKLCKADVSTVCLGLAASMGAFLLASGSKGKRFCMPNSRVMIHQPLGTAGGKATEMGIRIREMMYHKIKLNKILSRITGKPEQQIEADTDRDNFMNAWEAKEYGLIDAVIDDGKPGLVAPTADAGPPPKTRVWGLWKVEGSRKAKKNLPSEHKLLQNGHQGGDDEKGTEQEKEASSPV
179
A0A6I8PJE5
2.7.1.11
ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MNESAPGEETDPRHTTAHACEYTSVCNHVQRKPTQLPNSDSSPSVVFTERLLRADHRTQRLGGYSTTGLADDVSFHPPAPPPTRPQHPGVPLAHLGPLPLSPPPGMNAAVRAVVRVGIFTGARVYFVHEGYQGLVDGGENIREATWESVSMMLQLGGTVIGSARCRDFRTREGRLRAAANLVKRGITNLCVIGGDGSLTGADTFRAEWSGLLTDLQKSGGITAEEARRSSHLNIVGMVGSIDNDFCGTDMTVGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTALACGADWVFIPESPPEDDWEEHLCRRLSETRGRGSRLNIIIVAEGAIDKQGKPITSEDIKNLVVKRLGYDTRVTILGHVQRGGTPSAFDRILGSRKGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFEDAVKLRGRSFQNNWNVYKLLAHVRPPVTKSGTTVAVLNVGAPAAGMNAAVRSAVRIGLIQGHRMLVVHDGFEGLARGQCIEEANWSYVGGWTGQGGSKLGTKRTLPKKYFEEISVNITENNIQGLVIIGGFEGYTGSLELMEGRAQYEELCLPIVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIYEEPFSIHDLQVNVEHLVQKMKTTVKRGLVLRNEKCSENYTTDFIFNLYSEEGKGVFDSRKNVLGHMQQGGSPTPFDRNFGTKMGAKAVAWISGKIKECTRHGRIFANTADSACMLGMRKRSLVFQPLTDLKEQTDFQHRIPKEQWWLRLRPILKILAKYEIDLDTTDHAHLEHITQKRVSAETTF
84
A0A8M6Z2U3
2.7.11.25
ACT_SITE 331; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50"
MHTHSTMGSSPEVLSWTSCPSLLVGKLKEELKLTVVGDSIKKPNNNISPQALLPPAPPPPPPPPQIITDLAPPTTLPMPLHHLQLPVRDEEPGGTSPPCTALSEDSTREQGHFENSVLQLQEQEDAETPGSCGQGGCGSGGEEKNEENGCPMEHSGDDTHHHPHDDIKLHFHRAGTGSGGFLEGLFGCLRPVWNIIGKTYSTEYKLQQQVEMWEVPFEEISELQWLGSGAQGAVFLGKFRSEEVAIKKVREQKETDIKHLRKLKHPNIISFKGVCTQAPCYCIIMEYCAQGQLYEVLRAGRKITPCLLVDWASGIASGMNYLHLHKIIHRDLKSPNVLVTQNDSVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQGKPRNRPSFRQILLHLDIASADVLGTPQETYFKCQTEWREEVKKHFEKIKSEGTCIHRLDEELIRRRRDELRHALDIREHYERKLERANNLYMELSAIMLQLEVREKELLKREQAVEKKYPGTYKRHLVRPIVRPNAVEKLIKKKSSMNHKPGTQQPKRPDLLRSDGIPSVEPLPAPSPLSGSPKVSTPPGKTRYRSKPRHRRANSKGSHNEFPGVLKPNSGPPEEQQPLQEQNYLQNHPLPPPEPPLAKTRENAVATCANNLRYFGPAAALRSPQTDHLQRRLSGSSPDLISTAVDADSRLRRSSIPPGPAPLCPCCQAHPFPGCKHCQQTPAAPSHPQLPHYSLLSTNDGTPPASKRNLEPTAEGQDKEEKPALLHTLRPLRKTGDESSEEEEGEVDSEVEFPRRQRPHRCMSSFQSYSTFSSENLSVSDGEEGNTSDHSHSGPLEQLSGSQEEHLDELLSHTPEIPIDISTQSDGLSDKECAVRRVKTQISLGKLCADEHSYENPLHFGDSDCDTSDAECSDATIRNKPPGAPSSW
105
F0ZP67
1.11.1.24
ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MGLLKAGSIAPDFICKNQDGVDVKLKDFSDKPLVMFFFPSNIGMICTRENIEFKENYQKFIDANCHVVGISGDKIKKQKKFHCKNDLPFPLLIDRKRKIEKAFGAHFSRATFVIHNGEIVLSHLTHWFTSKSHIEESLKVVEFLNGNK
12
D8QSL1
2.7.11.25
ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MPSHSPIRWQKGNLLGVGSFGRVYKGFSDSGTFCAMKEVLVVDDPKSIESVKQLMQEINMLSSLRHPNIVQYLGSEMLDDSLYIYLEFVSGGSIHKVLQEYGAFKEPVIRSYTQQILSGLQYLHSMNKVHRDIKGANILVDTNGEVKLADFGMAKHISSSSLVLSFKGSPYWMAPEVCPRFLSSNTSMTPYPVDIWSLGCTIIEMATGKPPWSQYEGIAAMFKIGNSKETPTIPDTLSPVAKEFIRLCLQRNPDDRPTASQLLEHPFVKFLHDEHLPDGLPPLSPTFRSVVRDILCFPFFCFFWMMLSDQPA
105
A0A0K9NR24
2.3.2.26
ACT_SITE 995; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MFFTGDSSGRKRVDLGGRSSKERDRNVLLEQTRFERQKRLGLKKQIAAAIIIQKCFRGRKCVEKERSKIRREFINNFGECHLKFDLNCFSPQSTFLRHLLFFFQTSNQGDFYILVETCQKLLQSIKDGGDLISIIANKEYKENHAVVDNRLRQLSYFCIQAVHQNRNELKEQLLMGANLSSMPAIILLETIFTLTSPRLPWGNNIMDALIRKNVFSMLRDLILCGTDSQKSMGSLRAVSSMEHVIIAFASYKGHGHSYNPALNFTTQILSIPLLWHRFPYLKEVITGELSLHYVTEWAQCLHSNAIDFPGDVSPEFPGYACLLGNLLETAGDSLSQSSCSHNMAVDFAIVTSYLMGMLPSKNVSLQDYENDIAIDGESIDGESIKHLNSSLEKQIKNAVDPFLLENLVNSLFKDSMHNIHSLDGKLNDFEFIAINAICLFLYATFGILLPERIMTVLAYRTEIVQILWNFISRCHSNQQWEFFSKFASFLPVEAPGWLLPLSVFCPIYKHMLMIVDNEEFYEQEKPISLKDIRCLIVILRQILWELLWLNSGNSMALQKGPSLNSNKLSLDGVKNKVKFVTSELLSQLQDWNNRRQFTPFSDFHVQEAVDESFFFQGSIESPKVQDLLRLAPFLVPFTSRVKIFISQLSAARQSVGDHSTLSRRRFKIRRNQIFEDAYSVLRSLPEDELRGMIRVSFINEFGAEEAGIDGGGIFKDFMENVTRSGFDIQYGLFKETTDHLQYPNPGSGMIHEDHLQYFHFLGTVLGKAMLEGILVDIPFATFFLSKLKQKYNYLNDLPSLDPELYRHLLFLKNYTGDVSNLELYFVIVNNDYGEQREEELISGGKNVRVTKENVITFIHLVANYRLNTQIRNQSLHFLRGFQQLIKKEWIDMFNEHEIQLLISGSIDGMDVADLRLNTHYNGGYHENDEYIEMFWEIVKEMSSDNQKKFLKFVTGCSRGPLLGFKYLEPTFCIQRTSPADVNEIIVFRLPTSATCLNLLKLPPYRSKDQLQEKLLYAINAEAGFDLS
65
P52486
2.3.2.23
ACT_SITE 92; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MANMAVSRIKREFKEVMRSEEIVQCSIKIELVNDSWTELRGEIAGPPDTPYEGGKFVLEIKVPETYPFNPPKVRFITRIWHPNISSVTGAICLDILKDNWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVAYQFKDKYDLFLLTAKHWTNAYAGGPHTFPDCDSKIQRLRDMGIDEHEARAVLSKENWNLEKATEGLFS
64
Q9LEW0
3.4.19.12
ACT_SITE 186; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092"; ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092"
MSARISFLKNPDPCNHLSDYKLRYGTDGYKSFNNLFRCFNDARIKIKLQGIDIPRCSYCSVYQKRLYICLICRSISCSSHILLHTQLNKGHDIAIDVERSELYCCACIDQVYDSEFDEVVVSKQLFGLGMSVKSGADVVAVRSNKKRRLDSQLIIGSNFLVSPRDRREKWTFPLGLRGLNNLGSTCFMNAVLQALVHAPPLRNFWLSGQHNRDLCPRRTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFISLLDRIHENEGKSKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGSTSTTYDPFIDISLTLDSMNGFSPADCRKNRYSGGPSVNAIMPTLSGCLDFFTRSEKLGPDQKLNCQSCGEKRESSKQMSIRRLPLLLCLHVKRFEHSLTRKTSRKIDSYLQYPFRLNMSPYLSSSIIGKRFGNRIFAFDGEGEYDSSSSSSPSAEFEIFAVVTHKGMLESGHYVTYLRLKGLWYRCDDAWINEVEEEVVRGCECYMLFYAQETVIQKAHKELSYQVISMADAFPFADC
175
P57384
1.2.1.12
ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2"
MTIKVGINGFGRIGRVLFRLAQKRSDIEIIAINDLLAPEYIAYMLKYDSTHGVFKKHITFDKDNIIINGKNIRVTSIKDPEKLMWHDLSIDVVIESTGLFLKREQAYKHILAGSKKVVVTGPSKDDIPMFVRGANFHKYQGESIVSNASCTTNCLAPLSKVIDDNFGIIEGLMTTVHASTATQKIVDGASDKDWRGGRGALQNIIPSSTGAAIAVGKVLPNLNGKLTGMAFRVPVSNVSVVDLTVRYKKSATYSEICQKIQQASQKEMKGIMGYTEDEVVSTDFNGEELTSIFDAKAGLSLNKNFVKLIAWYDNETGYSSKVLDLVSLVSKK
22
A0A8V0XPF0
2.7.10.1
ACT_SITE 846; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MGCCDARGLLWRFGLFLPLLTARPAAGGHGASNQVVLLDTTAVLGELGWKTFPLNGWDAITEMDEHNHPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVVGTCKETFNLYYMESDESHGLKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEVREVGPINKKGFYLAFQDIGACIALVSVRVYYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSVGYEELDGSCHACRPGFYKAFAGNVKCSKCPPHSSTYVEATSVCQCEKGYFRAEKDPPTMACTRPPSAPRNVIFNINETALMLEWSPPSDTGGRKDLTYSVICKKCGSDASQCEICGGGIRFIPRHTGLINSSVTVLDFVSHVNYTFEIEATNGVSELSFSPKQFTAITVTTDQDAPSLIGMVRKDWASQNSIALSWQEPDFPHGAILDYEIKYYEKVYPRIAPAFWHYLRVEEHEQLSYSSTRSKAPSVIITGLKPATKYIFHIRVRTAAGYSGYSQKFEFETGDETLFKIAVPLPAPFPTSPLRLETISSQELQHFWKASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRAHLQNGNLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGYMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPTIGVKSLSRFLRAGFLNSILTSHPVSGGGSLPPSISSGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLMCKVSDFGLSRVLEDDPEAAYTTSGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFSDIVSFLDKLIRNPSTLHTLVEDVLVMPDSPGEVPEFPLFVSVSDWLDSIKMGQYKSNFMAAGFTTLDMVSRMSIDDIRRIGIVLIGHQRRIVSSLQTLRLHMMHIQEKGFHV
97
P34923
1.2.1.12
ACT_SITE 156; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10009"
MVGSAKIKVGINGFGRIGRLVARVALERDDIELVAINDPFITPEYMTYMFKYDSTHGQWKKTEVTLHSEGHLTFGGNPVAVYACRDPSEIPWGKHGADFVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVMGVNENKYSDEDIVSNASCTTNCLAPLAKVINDKFGILEGLMTTVHATTATQKTVDGPSSKDWRGGRSAATNIIPSATGAAKAVGKVLPELNGKLTGMAFRVPTTDVSVVDLTVRLEKPASYDAIKTAIKEASEGQMKGILGYTEDDVVSTDFITDSRSSIFDAKAGIALSDTFVKLVAWYDNEWGYSNRVVDLIVHMAKQGTSQ
22
A0A7I4B3X1
2.3.2.26
ACT_SITE 1289; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MITGTMQHVPRVTKVRQVSLGGASARELTRDELLGRVAQQRAVRSFGKQATASALLIQRVWRGRTIARQAAAQARTDWDKQFFLRHGEYQNPISADAISNQMLRPLFMFLRHSSCFDLHQTQEGAEDAGRLATCFRVLLQSIHNPDMRYNYCDLSVGFPDKMSKWIYQARQLLRLACAALGKKGHEFEPKASDNNHITLEASNLAGLAIRVIIGLTDSGTWKCFDEPGQEFRKRKAHLVVLGLLEWLASGSGGLYLAVQSYILANFPVPGIKDDHARSRGKKDKFIITASIITITLRPLLVLSAECSRDRDDEKTFEDKDYTTASNRAAAQFSAHILTIPFLPQRLPQPLLPALQHPSALSPCLRCFGVPIRNMIQAATTSSALPSLSSQQGKVDCKLAGVPLSAWALSNLVCLSSHTVNDNARFVNGLICQEYVQALCCLIEDLNPWVESTRKRKMAEKSANEEEDDRDVEDNKIIRIRNETSKTRETIIFQLLVESLRPLHQQWHLLQLMNEAALNDSAPMVFLVAKRLPKGDTDKLFSQSDVARLYSNLLPAFSVLNPFGGALPILNLLAFTPGILPQLWDWLQTSPGLAHLLNLDYFQGEPSIERCVETQLSKTQKELYNSKKRSTGGRLAAALGWKSRSKSACFAGSNNSFIVDNRSSGRAPERQEFLPGRSSIGGVSLTRTFEQSGILPPRRSVDRVRRTPRRSPVGRPNSDTPRPSVDQLVPTFRDERLWRSDVISDRPDTIRFLESPRVDTEAEVDVPYRMAEMDFSKKGPDGVPEDVLPVLLLFCAAYSHLLLVLDDEEFYEHQEPFTLDQQRVISTMLNTMVYCGFLSTFKRRNSRLMNVAIKCLRSLYERDCRHSFCPPGFWLGPAKTMRPPTVAAARSYEVALALERSGDSSQAPALGIILRTIPHVIPFEERVQIFREFVRSDKLLKMGGDAVGSGPGTIEVTVRRDHIVEDGFAQLNGLGSKLKSCVNVSFVNELGLKEAGLDYGGLFKEFLIDLAKAAFDPGYGLFFQTATEEGYLFPHAAAGSLGHGLRMLEFLGRIVGKALYEGILLEYSFSPLFISKLLGRYSFLDELSSLDAELHRNLVYLKHYGGDARDLALDFTVTEELFGKHYTVELRPGGADMVVTNENKLQYVHAMADYKLNRQMRPLVTAFARGMADIVDPQWLGLFNAKEFNQLLSGGDHDFDVDDLRVHTRYTGGYTESSRAVKLFWEVVRELTEEERCALLKFVTSCSRAPILGFKHLQPAFTIHRVECEASMWAVIGGQDVDRLPSASTCYNTLKLPTYKRAPTLREKLRYAIKSNTGFELS
65
A0A804J4T3
1.11.1.7
ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MELLCIILLSLSIPFAIGDLQVGFYNSSCPQAESEVLSVVSKHFATDHSVTAAFLRMYFHDCFVRGCDASILIAPTKKKKTERSAGPNLTVRGFEIIDEVKANLEAQCPSTVSCADIIALATRDAVALAGGPNYDIPTGRRDGLVSNPKDVRLPGPSLTVSGAFQFFSAKGFTLEEMVILLGSHTVGVAHCVFFRDRLGNFQGTGAPDPSMDPSLKAKLTRICGPRPKPLKKDPTAFLDQNTSFVVDNQYYNQLLVNKGVMQIDQELASDSSTASVVSGLASDEAGFLQKFADALVKLGNVEVLMGTGGNIRKKCTAFT
14
B7QIA7
2.3.1.48
ACT_SITE 323; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
GHLSGKFATHGTLECCPLYHNTTAADCETNLTLFDRTKVEVCPMQGRKAALKKGSFYHHVEVEGSDSFVDLSFVVLALLPQKYLPGGRTSPSLIHARNADREPDLSNLTPFYDLDMFREAQARAAEEMDGPARARSQEDQRASLRWQRTGGIRTLEMGRYEMDVWYSSPYPEEYQCLAKLYLCEFCLKYMNSHTILRRHTAKCVWRHPPGDEIYRKGSVSFFEVDGAKNKAYCQNLCLLAKLFLDHKTLYFDVEPFLFYVMTEADAEGCHVVGYFSKEKNSFLNYNVSCILTLPPYQRQGFGRMLIDFSYLLSKVENKVGSPEKPLSDLGLISYRSYWKSVVLDYLRRFEGKELSIKDLSQETAISAYDIVSTLQSLGMLKYWKGKHLVLRNQESLESLPAKSRKVRHDRALDPECLRWKPYALPNR
61
A0A1U8LM42
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MEPSYIFLTMAVTLLSMPPTGFGQGTTRVGFYSKTCPRAESIVKSTVESHFRSNPAIAPGLLRMHFHDCFVNGCDGSVLIDGPNTERKAVQNSLLRGFDVIDEAKAKLEAACPGVVSCADILALAARDSVVLTKGINWKVPTGRRDGKLSLQSDAAKLPGFTDSIESQKQQFARFGLNTQDLVTLVGGHTIGTAACLVFNYRLNNFTNGGPDPTINPSFLPQLRSLCPQNGNNFRRVDLDTGSANKFDTSFFTNLKNGRGVLESDQKLWTDASTRTFVQQFLGEKGVRKLNFGKEFAKSMVKMSNIGVKTGSNSEIRRVCSAIN
14
Q9FC99
2.7.1.11
ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01976"
MRIGVLTSGGDCPGLNAVIRSVVHRAVVDHGDEVIGFRDGWKGLLECDYLKLDLDAVGGILARGGTILGSSRVRPEHLRDGVERARGHVEELGLDAIIPIGGEGTLKAARLLSDNGLPIVGVPKTIDNDIAVTDVTFGFDTAVTVATEALDRLKTTAESHQRVLIVEVMGRHTGWIALHSGMAAGAHAVVVPERPFDIDELTAKVGERFSAGKRFAIVVAAEGAKPKAGTMDFDEGGKDVYGHERFAGIARQLSIELEERLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGEFGKMTALRGTDIEMVSLADAVESLKTVPDARYAEAECVL
84
A0A061E3B2
1.11.1.7
ACT_SITE 108; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MMWHNFETNGGTKPGLGISVGSLKAKDPSRLKRLKPSHRMEGIYSKQKFFLVFVLFHMVATLVKGQGTRVGFYASSCPLAESIVSSAVQSHFQSDPSVGPALLRMHFHDCFVHGCDASILIDGPDSEKKAPPNLGVRGYKVIDDAKAQLEATCPGVVSCADILALAARDAVVLANGPKWEVPTGRRDGMLSLASDTDTLPGFSESIEEQKKKFAAFGLNTRDLVTLVGAHTIGTTACQFFSYRLFNFTAVGNGADPSINPEFVSQLQTLCPPSSDDTGRVALDTDSVDSFDVSFFENLRNGRGILESDQMLWTDASTRSIAQSYLGVRGLRSLNFNIEFGRSMVKMSNIGVKTGTDGEIRKICSAIN
14
E9FUJ0
3.4.19.12
ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 163; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MADAGNWCLIESDPGVFSELIRDFEVQGVQVEELWSLDPEQFDNLKPIHGLIFLFKWVPNEEVVGTVVQDSRLDKIFFAKQVINNACATQAIISILLNCKHPDLHLGPTLGEFKEFTQAFDANMKGLALSNSDTIRSVHNSFARQTLFEFDSKASSKDDDTFHFVGYVPVDGRLYELDGLKEGPIDLGAVPAETDWIDVVRPIIEKRIQRYSEGEIHFNLMAIVPDRKLAWQKEIERLQSQPVVSTDMQTEIQRLLMLCEEEESKRKRQKIENVRRKHNYLPLIVQLLRMLGEKGQLLPLYEKAKQRAVAKTTTQKKS
175
Q9F7B2
3.1.3.48
ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 15; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P11064"
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLILTMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP
149
A7F0W2
2.7.11.1
ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MASKTPSSSSSRRPRNVGVGSFTINEEIGKGSFATVYRGTHVPSGSLVAIKSVNLGRLNKKLKDNLYVEIEILKSLHHPHIVALMDCRESTSHIHLMMEYCELGDLSYFIKKRDKLADNPSLFDMIRKYPMPVDGGLNQVVVRHFFKQLSSAMEFLRDRDFVHRDVKPQNLLLIPSPDWMAKSKNGPEAMKASKESIVPMVGINSLPMLKLADFGFARSLPSTSLAETLCGSPLYMAPEILRYEKYDARADLWSIGTVLYEMMTGKPPFRAANHVELLRKIEQNEDEIRFPSKTVFSRDLKDIARRFLKKRPEDRITFPEYFAHPVVTGPIPGLVGEDLPKEIITPSRSPEASVARHPSLRERQRENPTPKPVETTYESLIARDIGEQAPRSPHIEANQPVEIPGHKSGRPGSRDRPSAISAATAPNVDTLPRQRDRTERHYAPIGRPVSRKPSYDEQANLPVQEEIRSSDSITEAEQDVRDAREYVLVEKKAVEVNAFADEMAASPRLAHANHIPKQPTRRHTSMGAPNSTSGAVAVPPSRAVQKAQGNTRPDTSSARNSYGSYGKTGSSPSTASAIAKALQGASVRVFGVSWSPTLIGKGPSPQQLYNPYPAYPTPNTGFIGDARPIDEDQRVVNVIEDSATRSDVVYGFAEVKYRQLIPLAPSMNHGLGGPNNEKVGDAMDEDDGLTVEAIVNLSEEALVLYVKSLSLLSKSMDIAGAWWLRKNRGGVISGGHTPGSDSSSAVQAGNRINGAVQWVRTRFNEVLEKAELVRLKLVEAQKRLPEDHPGHPSNHATASKIVGGSSTTDGVVLSSGITAEKLMYDRALEMSRTAAINELANEDLPGCEISYTTAIRMLEAVLENDEELIPRKRSPSLREDKEKCDGGEVNGINFGDRKDVLKVLQMIRTRLHVLKKKMAVIARHQSMPPPSSPRHSHSGGTTPTIANTPPH
99
A0A0Q3IY09
3.1.1.11
ACT_SITE 275; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAMPWARLLACVVAVLLLLGANVVESGSRHQGRHHGRSSKSPLRRPGKKQAASPGPAKKRNETREAEAIELGFTSWVQYMGGPEHSAFLRALRLNVDVPARGASFLSPVRTLVVDKSPGAGNFTSIQAAVDSLPLINLARVVIRVNPGTYTEKVNISPMRGFVTVEGAAGAEKTVVQWGDTAETAGPWGRRSPLGTFASATFAVNAQFFVAKNITFKNTAPVPRPGALGKQGVALRISADNAAFVGCNFLGAQDTLYDHLGRHYYRDCYIEGSVDFIFGNALSLYEGCHVHAISPRYGALTAQGRTSLLDDTGFSFLNCRVTGSGALYLGRAWGTFSRVVFAYTYMDNIIIPRGWYNWGDPTREMTVFYGQYKCTGPGANYAGRVDWSRELTDEEAKPFISLSFIDGLEWLRL
125
A8BFD3
4.1.1.17
ACT_SITE 397; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MSVLTRASLVEYNLLPIGKGADISKVIVDAYAKSGREAVCVLNVSEIERHYNIWKTHLPEVQVRYAVKCNMHPLLLRSLHLLGAGFDCASPAEVRAALSAGCPPSKIIYANPQKPKRSIEEAFRLNCNTFTFDSEHELLSMLESTPPGKVGRFVLRLLPPDESSSICRFGVKFGASPSECYRLIRLCKHLGANLVGFSFHVGSGCGSVDSFRLAVQYMGEAAKFAKEQGFTLTVLNIGGGYMSKGAERHYDEPNRHAHITPPSFEEIASALREEINRIKVYFTNKSEDLEIMAEPGRFFAGDIMTLGTRIYGRRIIFDKIEDNSCLTEKEIMESGKASINEVKYYVGDGVYGYYNAILFDHVVPHLRFTDKHGNRKELSGAHAGSSLNTSSIFGPTCDSLDCILKERKLPLLDVGDWVITDAFGAYTYAAATEFNGIPHVSVVCCIEE
195
A0A9J7N454
3.1.1.4
ACT_SITE 81; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 131; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MASVRTLAIATVVCLGVVIVSSEDTERHERNRSRRNIFQTMMMLSCITEKSSFDYSDYGCYCGPGGQGKPVDILDQCCKVHDECYGTAEKNCFPLFEYIGVYEYECKDRKISCAIEDKTKLSCREFLCECDRKVNLCLTKNEKEYNSAYFNMDQAKCK
130
G1KG45
3.1.3.48
ACT_SITE 836; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1"
MNNRLRALGGRINNIRASELPKERIRSDIVCNVHFLDGSLQSFKVNKQDTGQVLLDLTFNHMGVTEKEYFGLQHCEESAVSPRWLESDKPIRKQLKGGSSCSLYFRVRFFMPDPNTLQQEKIRHLFFLQLKADILEGRLLCPVNSAVVLASYAVQSQLGDYSASTHLPGYLSDYCFIPEQNKDFLTKVESLHEQHSGLKQSEAESCYINIARTLEFYGVELHSGRDLHNLDLMIGIASGGIAIYRKLICTSFYPWVNIIKISFKRKKFFFQQRQKPSESREHIVAFNMLNYRACKNLWKSCVELHTFFQAKKMLPHEKKLQSHFWTMGSRTPTKSNNQCCRKVIGGMIWNPALRRSLSVEHLETKSLPSRSPPVTPNWRSPRLRHEIRKPKHSSVDNLANEISYITETEDVFYTYKDSSASKDSDSVLCQNLQQRNILENNSAQKSSPQTSNEVSSLQGSHPLGGRDKQFPETNENLAKGLLMDDSNQYYFDKNDVIDGDLLLIHILPDEDGKFGFNLKGGIDQKMPLVVSRIMPGSPSDKCAPKLLEGDQIVLINGRDISEHTHDQVVMFIKASRESHTRELVLLVRRKVIKPFAENKSEDETDSFNFPETILPACSEYGQTLEESMEQLKKGLESGTILIKFEQLYRKKPGLAITCAKLPQNMDKNRYKDVLPYDITRVVLRGEENYINANYVNMEIYSTGIVNKYIATQGPLSHTCVHFWQAVWDHKLSLIIMLTTLTERGRTKCHPYWPDPPDIVEFGNFRIKCRTEDCTIAYVFREILITNIETEEEHTVTHLQYVAWPDHGVPDDSTAFLEFVTYMRPKRIENEPVLVHCSAGIGRTGVLVAMETAMCLIERNQPVYPLDIVRKMRDHRPMMVQTSSQYKFVCEAILHVYKEGIVRPLDSR
149
E9H575
3.1.1.5
ACT_SITE 788; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
MLRVEVKGLVRSGVNKPHLARRPQPRRDRMPQSQLKNVEPAVEYLQEDISESIDQRLPQEEVYMLQNMRMFGSFPKPVLLELIKHIEPVHLQCNQNLFKIGHKDTNIYIVQSGRLRVYSTEADGSTINLKEVKRGEVFYSLLSFTDNLTGQPSAFKTVAAQAMEDSLVLQLPVSAFQKEVFDKQPDALIKTIQITMVRLQRVTFLALHQHLGLSAELVKSFPAKHHGERDSSPNPHRMREHAFVQKPINVNDPMDCATPPTTPLSKKKEQVKDEKDYQLLLQDGIDGFVKLLGLEDQSLLDGHIEVKKVISGTNIMKEDAMNNVALVYVISGTLGVSRRAASKNDDVQMFLAHSGELVGGLAVLTGEPSFFTVRSRHTTCVAMLSKSTFYSILSKWPKVVLHLARTVIDRLSPFVRQIDFALDWVYTESGEDLFRQEDESDCTYVVLSGRLRSVITDHEGKKELVEEYVRGDLVGFVDTLKENPRSTTVMAVRDTELAKLPKGLLDFIHLKFPMVVSRHLLGIIFHMFLGKCQTQSSSFNQALQQRSVQSNFSTVAILPVSDDVPLSPFSRELYTSLSCIGPTVLLTSDFIRRTLGTKIMESSHSGNECKLSTWLGQQEDQHKIVLYQCDQSLTPWTQRCIRQADCILIVALATMEPFVGIIEKQLETIAVHAQKELILLHKEGGDKPRNTFHWLNARSWCSSHHHIQCPPRIFSRKHASLLADGATKPAQLLDQNIHSDFSRLARLLTGESVGLVLGGGGARGAAHVGMIQAIQEAGIPIDMVGGVSIGAFMGALWCMEKDIHEVTRKASDWSHKMTQIWRHLVDLTYPVTSQFTGAWLNTMIRETFGEDSLIEDLWLPYFTITTDITSSCMRLHSYGSVWQYVRASMSLSGYYPPLCDPKDGHLLLDGGYVNNLPADVMRSRGAKHILAIDVGSQDDTDLYNYGDHLSGWWLLLNKWNPFASPVKVPNLHEIQSRLAYVSCVRQLEAVKKSDYCEYIRPPIGKYKTLQFGSFHEIKDVGYNHGKTTLLDCERLDTYTKPGVIR
131
A0A251UN78
3.1.1.11
ACT_SITE 446; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSSQTCLQKVNKNAIFQNTGCAVQILSLTMMNYGRLEPKSQSEPEPLEEAANKPPTKSKSKLKLLLIIGIILIVASAVSVALAVTLRPKSSGGSGSMIRPKPTKAISRVCSRTLYHDLCVNSFLDFPGSLSATDKDLVPISVNMSLRHVGKALYTSTDFNNMEMSTRVRSAYNDCLELMEESVDQLQQSLSTVGGQRVGNSEDVITWLSASLTNQDTCTEGLSESEEGEVKKLMQEKLKDLSELVSNSLAIYSSAGDLDGVPVENRRRRLMGEFPEWMSKKERRLMQMPAAVIQADIVVSKDGNGTCRTIKEAIKKAPEKSSRRFIIYVKAGRYEEDNLKVGRKKTNLMFIGDGKGKTVITGGISVADHVTTFHTASFAATGAGFMARDITFENYAGPAKHQAVALRIGADHSVVYRCSIIGYQDSLYVHSQRQFYRECDIYGTVDFIFGNAAVVLQNCNIYARKPMDRQKITITAQNRKDPNQNTGISIHSCKLLAQPDLVASNGSFQTFLGRPWKMYSRTVYLMSYMGDHIDPKGWLEWDGSFALDTLYYGEYMNYGPGGGVGRRVKWPGYRVITSAIEASRFTVAKFIYGTSWLPSTGVAFLAGLSE
125
C5YB26
1.11.1.7
ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MARSGNNVVVHVLVAMVVLWDGAAAGAAALPLPDLETTTTMNDTVTGSLSADFHLESCPDLHSMVRSAVQAARNQDVQITAGLLRIFFHDCFPQGCDASLLLDKTHPGSEQHVHPQNAGLNHKALQLIESIRDMVHRRCGERSVSCADILAVATSHAVNLAGGPFINMQLGHRDSVDPAQPWQVQTLPAPTADVTTLFNSFAGKGFVNAIDVVALSGAHTVGKARCSSFSDRTNNPNDDGFARELAAFCAGDGNRQHNLDVITPDSFDNRYFADLINRKGVLTSDQALTNDGRTAWIVNVFAHDQANFFQKFAQAMEKMSRLTSPGGVKARRNCFKRDAGVNIQTTVAAAGSGDDESQLAASA
14
A0A8R1Y5I1
2.3.1.48
ACT_SITE 624; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MTTPGSEKGKLTDSLSAFFTPTPGGRRRKTTINTHEDSTSDEEPDGRASKLMGPLSGEVGTEGAGGSGTASKTTPSSTTSSSHHHHRRAEEQLHDALSPYFSAASGKRRSAVKGEYARMQQGGRRRVRAHAARRGRRRRRRRQSGRALEWRRGHAVARRRRRRTVARPQLAEVLAPRTPAQESIGRVDTGAGRIPNVRLDERRREGRRGRGRGGGAGAEDGRSLASAQVAEHVTLQEERRRRWGGVEDNSASAALFSSPDDRRGGKGQRKVKKEIESDESEDDAPLRKNKSSRHPPPPQASTATTSKSPLHKRIKRELRSSDEDTTQSDGSDSDDKPLMQRRAAPGSSLRPAAAAAEPSTSRGSPEKKMSKKIKEEPRKSVAVPAANIKPPQSPIDSTGTGVGSSLGGIETWSDIKITQDQWAAYEACTEKANAAIEKTPLLTADGREIPRWPETICFGKWEMETWFTAPYPNEYANTKKLYICEFCLKYMRTFTQLERHAEKCKSWHPPGNEIYRKDDVSVFEVDGNVAGIYCQNLCLLAKLYLDHKTLYYDVEPFLFYIVTKNDETGCHFVGYFSKEKYSAQKFNLSCIVTLPCYHKQGFGRFLIDFSYLLTRREKMVGSPERPLSDLGRVSYAAYWRSALLEYMRQKVKVEKNEGLQFSEIAADTGISLYDATTTMEALGMLVKSENGGMEFLYNEELVERHWTKAHANKGRIWLDETALKWIPVAHTPSKDFAIIVRSPARMVSPTPSHAGVTPTGVPLAACGSTIKRGPLAAANAVPSAAAAAAAASGPTPRKQPGAVKMAEKKRATRQLKLEDVGFGGGATSSSKTSTATPARKSRRIAAASEDSSLASTSSDEEKKKKPESKGTCKPDTGKRRNRRSEDSDSSDEEREGGGGGGGASPKKRPSASGPSSASTRRASGASRGAAAPPASPPKGRKRGGKGGRGRESEDDEEGEVSSAYATTSSDSDDSSDSDSDQDTSFHPQTARRPPPPSKGKKGSKGKPTPQIPQKKGARAAPQKGKKNGVTGTTVTPSAGASTTTSPPSTVAVKGRKKELKSPGKVFPSNYSAMIAARKQQQAAAAAAESAAAPGCSSQAAAAAAGADLAAASTAAAAAGEEDGRPASPADSLCSTATIPMRQATEWAADQSMLTDDGCAHESEGREHTPGPSASALSSRPSSCGRGRKVERRRNGRTRRGETSEDEQSDSSIGGSSSGSSLFRGASPRPMGDRVPSTSGGTMNMGWDEEETDHDRTMRIEQLENGPISAPPVSSSSSSERPPSLQAMSPIEPRPDQPTLGSLLSHEMAKGGGGLLSAAAAAAGAASSSSLLQQLQLQQQQRKPSAAATAALTPMSNGVGKAGPSSAAVGAAAAAAAGAACSTDDSEDDAPPCLSPQYARVGEREGDFSGAANGGGGEGASSSNEDGGASSDASAAPILAPSDPHDVAGPRGARSLCSSCSRPEQQQQQQWPRPHGSPHLGAVVCCSSCSLRSLQYAAQGAPPLGGSAAVRAAVDGHGRVPSGAKFWHGPSLAARPIIGWGRARPSTYRCRPDLAPAAATAAAAAHAAAHDTADDDVPGFGLGRRYAVHAGQRTSLLRPQHAREHAAAVADYAPYAAAAAATTAHAAVCQPHEYAAADVLAAALFRALYALGPPRHVRRRGRRRAGKCARRIRWTADAAGWSLQPVHSSTSDGRNHGRTGQRQSAAVQLADACRVAAAVSAGAAPARGCSSSCSTGAGRSPQQRGCVGRTARCCWRDCCYYRHCRYIEEAVFYWRRHGAAHALTPRSTATAASAAGAAPAAADEPADGAGDDGTTEHAEHALHAVQSGVQQRVHAVSGDGGHAAIRAHRIPAWHDAVGQGRPGSGRSGCSRRSCDHALLRALPRHAADAAATAAGCCSSRSCILADHALARSALSRHGRSARRHQQFHAKRRNAVLSRIPANPAIPVL
61
H9G588
3.1.4.11
ACT_SITE 400; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 447; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MVLLSLCVCVCVCFPAQEEEEEEKKGGGKERRRERRPRLAPPSPSRQPRQGKGRQRRQKNWGFPGGAMAGGRPGVHALQLEPLRVHETLLKGSKFMKWDEEPTSRALVTLRVDPQGFFLYWTGPNMEVDILDISSIRDTRTGRYAKLPKDLKIREILGFGGPEQRPEEKLLTVIHGPDMVNVSFLNFMAVVQDDTAKLWTEELFKLATNILAQNASRNTFLQKAYTRLKIQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIKPDEFTLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLSLDQLMDFINQKQRDPRLNEVLYPPLTQAQVRQLIDKYEPNQQFQQRDQMSMEGFGRYLGGEENAIVPPEKLDLSDDMTQPLSGYFINSSHNTYLTAGQLTGNSSVEMYRQVLLSGCRCIELDCWKGRPQDEEPFITHGFTMTTEIPFKEVIEAIAESAFKASPFPVILSFENHVDSAKQQAKMAEYCRNIFGDALLIDPFEKYPLQPGVPLPNPQELLGRILVKNKKRRTHSKASEGSVRKRVLEQMPSTYSDSSGVGEPGSPALGSPFADASEVLSPVMTNGEEKSSDRVTKLGEPRKSIDREAESEEEEEQQDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEVASKRNKSYEMSSFVETKGLEQLTNSPMEFVEYNKKQLSRIYPKGTRVDSSNYMPQVFWNAGCQMVALNFQSLDLPMQLNLGIFEYNRRSGYLLKPEFMRRQDKLFDPFTEDIIDGIVANTVKVKIISGQFLSDKRVGIYVEVDMFGLPVDTKRKFRTRTSQGNSFNPVWDEEPFVFHKVVLPTLASLRIAVFEEGGKFVGHRILPVSAIRSGYHYICLRSESNQPLCLPALLVYTEAYDYIPDDHQNYAEALINPIRHVNLMDQRAKQLAALIGESEQENAERPRESLSRSSSSATPGPTEEAHKPPPVLLSPTRSPSVVPSQVQRDDLIASILAEISPQSIEELRQQKAFVKLLKKQYRELKELRRKHMKKICSLNKKQNSNFTLAERSRILRSREGSQSSVEAVRQGQEQDGTRRKLDLQEWQMQGLLQLRESQHQLERDCKREHLHQAQQRLRDIARECQAAQLKKLKETNEKEKKELQKILDRKRHNSITEAKSRERNKKDVELTEINRRHITESVNSIRRLEEAQKRRQEKLLGGHQGILQLIDEEEPRLLAQLEGECDLEALALRQEIGRYLQEELDGGVSNGHPPPGSGASPAPTEEEEFTVL
153
Q6PCG3
3.5.1.23
ACT_SITE 118; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR017632-1"
MLYLLLFLGSCSFSYPYYTEDLEAPRYSINLDDPPEERWEPILNNYNHTEIRVVVKRILEIVIPEWALHILRPLAGVYLTFFAGKTYAGEIRGISKVLSMSTGEVVILNLGYEAAMFCTSIIAEDEKGNVYLGRNMDFLFSNLLAKLTMDVDFKKNGEIAYTGTTFVGYVGLVTGQSPNKFTVAANAREYDTSWWINAISALTKNSSPLSWLIRDTLNEAKSYTDAFLKLSKGPIITQVFFILAGTKAGEGAVITRNRNGVVDARFLDNKRGKWFLVQTNYDHWKMPPTFDDRRTPATAALDFTSQKNISMDSLYQVLSVPPVLNRMTIHTTLMSAAFPENYTTVVRYKVYNKTMIWNIPIMTANGTESGLWQIPRTTENNTQDSYALADTEND
182
A0A7M7PLY5
3.4.19.12
ACT_SITE 90; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MAGASAGDWCLIESDPGVFTELIRGFGVGGMQVEEIWTLDDDTALEKLKPVHGLIFLFKWQPGMDSSGTIVQDSRLDDIFFAKQVINNACATQAILSVLMNCHHGDMTLGNQLKEFKEFTSTFDPTMKGLTISNSEVIKDVHNSFARQQMFEFDSRQANKDDDVYHFVSYMPIQGRLYELDGLKDGPVDLGRADDGDWLKTVKPVIEERIRKYSANEIHFNLMALISDRRMIFNKEISRLQNQLKAVQGQEELMDTDQSGPVSADAIQSELSRYRLLQEDEDRKIKTFKVENVRRKHNYLPLIMELLKILASKGELVPLVKEAKEKALAKQEKEKQKKVTEAR
175
A0A9J7KJ60
2.7.11.25
ACT_SITE 264; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50"
MHTEPVMAATAVADRPDHAILHKDSPIDSRNVPSHMNILTSNDVNERCKSPGVLSTSTDTENFANSKLCIEDSDETDPNRSPTPCTSQCAPGEKSSSSDNAQNVQLQYTGANRSGSWFDGLLGCLRPVWTIIGKATTNELKNGDDWEIPFENICNLQWLGSGAQGAVFLGTLNGEKVAVKKVREETETEIRHLRKLNHPNIIKFKGVCTQAPCYCIIMEYCPQGQLYENIRRGLEIPPMRMVEWAKQIASGMYYLHQHKIIHRDLKSPNVLLGVNDSLKISDFGTSKLWSDRSTQMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGESPYKDVDSSAIIWGVGSNSLHLPVPTTCPEGFKLLLKQCWSGKPRNRPSFKHILMHLDIAGCEIIGQNRDTYFKTQESWREEISIHFEKIRSEGNQIHKLDEELVSRRREELRHAMDIREHYEKKLERANNLYMELSTCMLQLENRERELMRLERRRKRRGRNGKEKLLDMKLKKEKISIKPMIKAQHQAVERLMKNKGAKYKTSLHLLQRVDSPSSEPRHYGDAEHYVHFSPRSSPSSPRHSPSKLRGQRRMHRRSTISHGGSAPGSPLASNKMSPVKERKLHNILKSDTTLQNDANETRLARTALRHSAPGRAMRQYARDPDTRRNNERTDGGRDSCRKSPSRTHAEFTQVLYNINTKGSTSESDNGRGDSRRNSGNFGDDGGSSEQEEKHELGAEGGEEPCIPNNVLPSPGHCVTCKCHMSHSSPHVDGIPSRSGTPTGNVEGQGEEDHGVEGANPQETEEEQELPDLQSRDEEKQNAEESSSEEEEGEVDSEIDFPRAQSRPIRCPNSRQSYSTVSSEGGMSEEENMSDRSLGPTPDLLSTTSSFNNTGEFHDVSHALADMAHSLSDGLSDKEMNVRRVRSQVREHVYENPLAMLDSDESSDDCSDATTGTVNFKNSTASW
105
A0A3B6TFU9
5.1.3.3
ACT_SITE 234; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 366; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MHDLLPVPTGTPLLGLPFFQLFLIRPHSVEEQHLAMKMARALLVAPLLASCFVALGLSGRADAAAETKTVGVYELKKGDFSIKVTNWGATLMSVILPDSRGNLGDVILGYDTVAEYVNGTAYFGGLIGRVANRIANARFTLDGKAYRLVPNDGNNTLHGGHRGFDKVVWTVKEHVAGGSSPFITLYYHSFDGEQGFPGDVDVHVKYQLSGPHELSVRMNATARGKATPVNLAHHAYWNLGGHGSGSVLGEEVRLFASRYTPVDAALIPTGHLAPVAGTPYDFRTPAAVGSRIGGLLSRGVNGYDINYVVDGGGLRPVAVVRDGASGRAMELWADQPGVQFYTANGLSGVRGKGGKVYGRYGALCLETQGFPDAVNRPSFPSQIVRPGKVYMHHMVFKFSF
211
Q1ZXR2
2.7.11.1
ACT_SITE 634; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNIKFDMFVKDSNSIDSEELLNNYLTLNVVSQELLIQNAQKPLTPLSIEIGKTRTINKNIKSKLNFIMPSFCEYYELEGNYILYFKKLKIFEDFIIYKDQSIPISNQMEIKIGKGKVLVNGKKISIKDEEIKNNFIRDLNFLSSIKNFRNQYSHGNEIEAVESISKKENSINSLVIPTFIKFLGEIIIKTKDTIKFKNLMVLSDNFNILDDVIYQVENNELNLKNSKNSVVYKSIKKSIPIYLLSKVFEHTEFYILEKNNSILNFFCKKRIEDFNENSEDKEFNSTSENDSHESSIDLKCSSEVSQIKIERFHEYVSLFSKCISKNVDINHKNDKGDTALHNTIKNLKKESGPMVAALLSCGANANIRNNKHKVPLHFAIEFGDESIIKILLAFGAKPFLEDSISFSERDPGKIYKELNKSGQVLKILYEIGVITKLFDNFSVLQHVKTFILLEILFQNSMNILKSDIFSSILNNIFNQNIVRFKLIIQNLKEPPLSKFKKIEKFDRSELGKLIGKGANGKVYELHYNFGGVEKHCAVKEIKVDKYRVGAVLKEIESTALSQSPFTVGIYGYFEDEKNNFLYIFLEYCPNGNLFDIINKEKMKSFDEFFSYAFGVVHCTHDIHSNPKGALIHRDIKASNFLVDKNNLVKIGDFGTARFDCTLNLSSLKNGAGTVCFQAPEASRGKATIQSDIYSLGVVLFELCGAIPYKNYNYFFPFGDLKYLRVASAVSNYLRPILHPVIPQPLSDLIYSMLNHNEYDRPTSFEVFQKLKKVQEDYESNKEEWNSIFNTIDMKEDQQFHHERQEKVALMIKKKYLLTRPITESLVNHYDNIVFNIDYSISLNF
99
E3KKH6
3.4.19.12
ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MSEGWCLTESDPAIFTILLSELGVSGLQVEELWSLDNQSLEQLKPVHALIFLFKYVNSDQRDPSKQAGEQQPAPPGTWFAHQVITNACATLAILNAVMNIPSTSSKIQLGQELSQLKEFSVDLDSQMTGELLTNSERIRAVHNSFARPDPFQRDEPKQMSTEDAYHFITYLPLQGKLYELDGLNGLPVFHGKIPEGQSWTSLAREVIQNRINTYSSTEVHFNLMAVCEDRLNVLEERKASMTVDSMGYENLKMEIEAEEAKRKRWAEEVAIKRHNHIGLIHALMVGLAKHGSLAERVNLAKQKMVDRQRNRTGGHEMQLD
175
P48456
3.1.3.16
ACT_SITE 191; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q08209"
MSATSTRSSVTRKSSLSKSSSSDKSAKSSSNSSKSPTAASGNKQKMQYTKTRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVTRSSSSSSNNNNNNSNTSSTTTTKDISNTSSNDTATVTKTSRTTVKSATTSNVRAGFTAKKFP
144
Q69QL4
1.11.1.7
ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKLTVAIVCAMATALLAAAPSSAEAGDGELKVGYYDNKCSGVEDIVRSHVIKAIIQDRGIGGSLIRLIFHDCFVRGCDGSVLLNASDENPRPETAAPVSIGLEGFDILEEIKADLERRCPGVVSCADILIFAARDASSILSNGRVRFDVPAGRLDGVVSSAYEAQAELPDPTFTIRQLIDNFARKNFTVEELVVLSGAHSVGDGHCSSFTARLAAPPDQITPSYRNLLNYRCSRGGGADPAVVNNARDEDLATVARFMPAFVGKLRPVSALDNTYYRNNLDKVVNFNSDWQLLTQDEARGHVREYADNAALWDHDFAASLLKLSKLPMPVGSKGEIRNKCGAINHSKS
14
M5VY20
2.1.1.37
ACT_SITE 360; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MENSLVEVKYGCHSKKTPRKKKLTRARKKERTAQGFTQTYCKSLYCPERGAFFSLSRDTMGLGSGACHSCKMNEAEEAKEVFKLNSSKTGMETEIFKAGKKLGLTTYVGYQVLEIVVMKESKRPEIESTQVKVRRFFRPEDISVEKAYSSDIREVYYSEETHIMPVNNIEIKCEVRKKSDLPVCNAPVIFQHIFFCEHLYDPSKGSIKQLPAHIKLRYSTAGGDADSRKRKGKCKEGENVSEVENQRADSEQKRLATLDIFAGCGGLSDGLHQSGASITKWAIEYEEPAGDAFKLNHPESLVFIINCNVILRAVMEKCGDTDDCIATSEAAELAASLDEKVKNDLPLPGQVDFINGGPPCQGFSRMNRFNQSTWSKVQCEMILAFLSFADYFRPKYFLLENVRNFVSFNKGQTFRLTLASLLEMGYQVRFGILEAGAYGVSQSRKRAFIWAAAQGEILPEWPEPMHVFGVPELKITLSGNSQYAAVRSTASGAPFRSITVRDTIGDLPAVGNGASKGNLDGQIVDLIPWCLPNTAKRHNQWKGLFGRLDWEGNFPTSITDPKPMGKVGMCFHPDQDRILTVRECARSQGFADSYQFSGTVLHKHRQIGNAVPPTLAYALGLNSRKQLTAR
47
M4DUD8
3.1.1.11
ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGITDMVLFGLLLVNALLPVDTSGRMPFTYRNQLQRLCSSTEYTSLCVQTLREFRHGSPTSLDFVSFLVNKTMSGSSNLIPPLSSSMASYEVISLDDSTNTLPSPSVADSCERLMKMSTRRLQQAMEALNGSSRKRTTKHDVQTWLSAAMTFQQSCKDSVLDSGGHSSSAVSHITQKMDHLSRLVSNSLALVGTFMENPKPTVLPRWVSAGERKLLASRTSRSRPHVLVAKDGSGDYRTVMEAVNAASGNGRFIIYVKRGIYKEKVRIEKDEITLIGEGKDLTVIVGDDSAAGGTSVPDTATMTVTGDGFIARDIGIKNTAGPRGKQAIALSITSDQSVLYRCSISGYQDTLYAAALRQFYRECDIYGTIDFIFGNAAAVFQSCNLILRRPSDVKAYNVILANGRTDQRQNTGFALHSCRILTDLDFSGMKHRYSSYLGRPWKKYSRSIVMETYIDDAIAEEGWAGWLNSGDEVLKTLYFGEFKNYGPKARVSKRVWQGFHVIGFEEASYFSVGKFLDGVSWLPSTGISFASGI
125
Q9HQT4
2.7.7.7
ACT_SITE 131; /evidence="ECO:0000255|HAMAP-Rule:MF_01113"
MPAGERLPGAPAREERIVVHVDMDCFYASCERRREPALRGAPVVVGMGYEPDQTVGAVATASYEAREYGVESAQAISAALERLPRKADAPDASAAGYYRPVDMAYYESVSESVSEILHGLGDPVREVSIDEAYLDVTDRTAWDVAAGFGRHIKQRIARSVGVPASVGIAPDMSTAKLASDHEKPDGLVVVPPESVQSFLAPLDVADLHGVGPVHARALRERGIETVGELADADPYVLEAAFGERGREFHRRARGADSRPVEPRGKPKSLSRESSFDGATESFDRVREQAAALSGAVADRASRTNASYRTIGVKVVTPPYDVQTRAESLPGPVDDPALLEAVSQSLLDEFEGAAVRKVGVRVSNLVFSEREQATLAGFSGDETGDGGGHEGGACGGAGRGSCGGQTTLDEFT
121
A0A804JVG0
2.7.1.11
ACT_SITE 274; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MESLPNPPVPQKIGADSNGSAANSNRLFDLRSSLSSVKLPVRNGAEVKLRLGKKMGSEARLCPKIEYGDGGYVLEDVPHLTDYLPDLPTYPNPLQDNTAYSVVKQYFVNLDDTVAQKIVVHKNSPRETHFRRAGPRQKVYFESDEVHACIVTCGGLCPGLNTVIREIVCGLSDMYGVTKILGIEGGYRGFYARNTISLTTKSVNDIHKRGGTILGTSRGGHDTIKIVDSIQDRGINQVYIIGGDGTQKGASAIFEEIQRRGLKVAIAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEADSVENGIGVVKLMGRYSGFIAMYATLASRDVDCCLIPESPFYLEGKGGLLEFIEKRLKENGHMVIVVAEGAGQDLLVKSMQSMDHEDASGNKLLLDVGLWLSQKIKDHFSSNKKKMSINLKYIDPTYMIRAVPSNASDNVYCTLLAHSAIHGAMAGYTGFTIGPVNGRHAYIPFCRVTETCKKVVITDRMWARLLSSTNQPSFLSHEHIEDANKEDEPSTESLPNDHDVRISDGSI
84
O13974
3.4.19.12
ACT_SITE 143; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 146; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 247; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 323; /evidence="ECO:0000250|UniProtKB:Q96FW1"
MSSLRLRLKYENQSAVETVEANATVGSFLDLVAAKFSLPRNSIALKFGFPPQDIPLVNSDVPLSTLVSSGQQILVLKNAATSFSTNEPAKPPIPNAATKPTFPPQTEISNPPAVSHQSKNTSQDPPYVSTPIGDIALRVMPDDNSCLFRALSKPLGFSPYELREIVANQVLSNPDIYSTAILGKPSIEYASWIRKETSWGGYIELSILSSHFGVEICSVDVKTGRVDSYNPQPATGQRTYIVYSGIHYDLAALAAVLWDTDVDVVLFDASDVTITPYVQQLASLLKNMHYYTDTASFSIRCTICGTGLVGEKDATAHALATGHTQFGEY
175
A6IEX1
2.7.10.2
ACT_SITE 346; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1"
MVLYCLLKNAEPLIKIYSVSHSETFSPACTEMADAETDQELNKKLNFSFCEEDTENEGQMTAQDIGRAQSQKPRRDQSEELEGPVSSPRDELYTSLNRDKQSPGPALRTSVSDFSTCPDTPVLNSKSKLPVPTNFSTPKNLLGQPEISSLEKLYVRSSKHLRLTPTSLMDEKTSLSLVNINPFTPETYRKLFLQSKGKRKTRDYLVLQETNMASRYEKEFFEVEKIGVGEFGTVYKCIKRLDGCIYAIKRSAKSFSGLSNDLDLHEVYAHAVLGHHPHVVRYYSSWVEDNHVVIQNEYCNGGSLQAAISENADSDNHFQEPKLKDILLQISLGLKYIHNSGMVHLDIKPSNIFICHKIQSDCPVGPEETESEADWFLNANVMYKIGDLGHATSISKPKVEEGDTRFLANEILQENYQHLPKADIFALGLTIAMAAGAEPLPINGDKWHHIRKGNFPEISQELSDDFYGLLKNMIHPVPEERPSAATLARSRILWPFLEKTEELQKQLNLEKSKTATLKRELKKAQHIHTPQRDVHHCYQQTYKSSRSTRHLLVGGRRKEPPSFTCGAASV
98
A2DTA3
2.3.1.48
ACT_SITE 281; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MNPKTIHVGDRVVVYCEQYQQLMEAIVVGAKVSTKQLYIHYVHQDKRLDRWISVKEVTDDPNVVIKTKAGKSAIRNHKILNTDELDVEKLAVEYKQFEKAHQEVTRIRNIDRITIGPYTIQAWYYSPYPNPFGKMEHLYICDHCFQYFASAEELAKHLQVTGEKCPPGNEIYRQGNLSIFEMKGMVNKVPCQCLCLLSKLFLDHKTLFYDVEGFNFYVVCECDDNGAHIAAYFSKEVNSSAYNVLSCITTLPPYQKKGYGNLCISLSYELARRSRMSGGPERPLSDLGKLAFASYWKDTLLEMFSTRLSEMTSIDNIVILTSIQKLDVIETLKQINCLTRVKGDYEIDLHSPQLKQAIEAHQKVPPKRRIDPQYLTWIPEA
61
Q9RTM3
3.4.21.89
ACT_SITE 38; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 103; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MKRPAGVRRFWREWAGPVCWALLVTQFGASAVRVDGASMLPALRHGEWLALPKAEGWVHRLGLGEYQRGDVVVFKPPRSAAYEWTNVYRGVNLPWAYRPYLVKRVVGLPGDTVQVRAGTLYVNGQPVPEPRTLNYWAAFCHDTGSDLANTPPLKVPAAHYFVMGDNRSPGGSLDSRVFGPVPAWDVDSRAVASLWPLARQEEARPACDEQPQPEKRVQLSGPVQWNPRWGFGGR
178
F7C211
2.7.10.1
ACT_SITE 613; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1"
MQPLASVLGTLLAAAGFLVIHAFTSEEVEQEPCQAPGPEELEQHLTLALGQALRLCCGRANRGGHWYKEGTRLAPSGRVRAWRGRLEIATLVYEDAGLYLCVSRGSGHVLHNLTISVIDSLASGDDDEDSDSSPKDLPKGHIYPQQGPYWTHPHRMEKKLHAVPAGNTVKFRCPAAGNPMPTIRWLKNGEDFHGEHRIGGIRLRHQHWSLVMESVVPSDRGTYTCVIENALGSLRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIEVNGSSFGADGFPFVQVLKTADINSSEVEVLYLRNVSSEDAGEYTCLAGNSIGLSYQSAWLTVLPEERLVWEAAASEVKATDIIMYTSGSVAILVILVIAGLCRGQALSSRPPHQPLAVQKLSRFPLIRQFSLESGSSGKLSSSLVRGGRLSSSCTPMLPGLVELDLPLDAKWEFPRDRLVLGKPLGEGCFGQVVWAEAYGMDPQQPDGAATVAIKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEFAAKGNLREYLRARRPPSPDYTLEAPRTPEEQLSFQALVSCAYQVARGMEYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPSHCPPELYMLMRECWHAVPSQRPTFKQLVEALNKLLTAISEEYLDLSMPFEQYSPAAEDTSSTCSSNDSVFTHEPLAPGGLSPSPFTYHNVRT
97
Q2QZK1
3.1.1.11
ACT_SITE 254; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MDRPNLAVAVVGLLAVVAATLPAPSWQFFDLFLPAGPSHRSSGGGFGKWVLMNHEEYVEKKSLYAMKAAGDIGGKTIDASLSAAEEAKVTWVVDPKGTPGDTTFTTIAAALEKVPEGNTKRVILDLKPGAEFREKLLLNITKPYITFKSDPANPAVIAWNDMAATRGKDGKPVGTVGSTTVAVESDYFMAYGVVFKNDAPLAKPGAEGGQAVALRLFGTKAAIYNCTIDGGQDTLYDHKGLHYIKDSLIMGSVDFIFGFGRSLYEGCTIVSVTKEVSVLTAQQRTKTIEGAIESGFSFKNCSIKGQGQIYLGRAWGDSSRVVYSYTDMSKEVVPIGWDGWNIAKPESSGIYYGEFKCTGPGSDAKKRVGWALDLTADQAKPFIGTHYIYGDSWILPPPDGKSAASTSTASKSTASAIPRNSTAPATATESNSTAPATPSNSTAPVTASNSTAPATASSSNPPATKSYSGPPATPSASSTPAKASR
125
P44311
1.1.1.49
ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00966"
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMREALIHNEETTPETLDAFCSHLYYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQTLDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQNHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPANSRTETYIALRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLAGAQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQGKVWRKPSGLMKKKV
6
P06782
2.7.11.1
ACT_SITE 177; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSSNNNTNTAPANANSSHHHHHHHHHHHHHGHGGSNSTLNNPKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLKPHPEEENENNDSKKDGSSPDNDEIDDNLVNILSSTMGYEKDEIYESLESSEDTPAFNEIRDAYMLIKENKSLIKDMKANKSVSDELDTFLSQSPPTFQQQSKSHQKSQVDHETAKQHARRMASAITQQRTYHQSPFMDQYKEEDSTVSILPTSLPQIHRANMLAQGSPAASKISPLVTKKSKTRWHFGIRSRSYPLDVMGEIYIALKNLGAEWAKPSEEDLWTIKLRWKYDIGNKTNTNEKIPDLMKMVIQLFQIETNNYLVDFKFDGWESSYGDDTTVSNISEDEMSTFSAYPFLHLTTKLIMELAVNSQSN
99
D6WXD9
4.1.1.50
ACT_SITE 67; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 81; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 236; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MSDSVQYFEGVEKLLEIWFTTSNSNSKTADLRKIPRAKLESLLKIVRCEIISFMKNEQVDAYVLSESSMFISKRRFILKTCGTTTPLLCLEPLLLLAEQYAGFTEVEDLFYSRKNYKRPELQVTPHKHFDQEVALLDSLFPDGVAYCMGAVNKDCWYLYTLNPFPRRTPHQPLPAVKEEPDQTLEILMTDLDPEIMSIFSKEESLNATEATKRSGIDKIIPNMIIDDFLFEPCGYSMNGVTKNGCYMTIHITPEPEFSYVSFETNVPCSSYREIISKVLDTFLPGKFTVTVFANQASPTKDTAEEFQYLSSIGEWSRRDIQHCQFKNYDLIYTFYSKFPS
196
Q8P519
3.2.1.28
ACT_SITE 329; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060"; ACT_SITE 511; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060"
MPHAPARSGDAMSAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPALINADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQLQKEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDRPAADVYRDLRAGAESGWDYTSRWLADGKTLSTIRTTAIVPIDLNSLLYHLERTLAQACAHTGTACSQDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTLSNQVTAAALYPLFAGLASDDHAKRTATSVRARLLRPGGLATTALKTGQQWDEPNGWAPLQWVAVDGLRRYGEDGLARTIGERFLTQVQALFAREHKLVEKYGLDADAAGGGGGEYALQDGFGWTNGVTLMLLNLYPSQGATQAPAKTKRKPEPAAP
165
A0A059D881
4.1.1.50
ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 247; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MDLEVSAIGFEGYEKRLEISFYEPGLFGDPDGRGLRSLSRAQLDEIIKPAECTIVSSLSNDHVDSYVLSESSLFVYPYKIVIKTCGTTRLLKSIPPILNLAGSLSLTVRSAKYTRGCFLCPGAQPYPHRNFSEEVYVLDRYFGNLGSGRKAYLLGGSNKTKRWHVYSASADEVESVSPVYTMEICMTGLNKESSSVFFKFQSGSAAAMTINSGIRKILPNSEICAFGFEPCGYSMNAIEGSATSTIHVTPEDGFSYASFEAVGYDPKDINYNQLIGRVLACFRPKEFSVAVHANVAAKSLEQNCSLNVKGYCSGERCLEELGAGGSIMYQRFVMTGRSARPTMLISKI
196
Q7MBB9
5.4.99.12
ACT_SITE 65; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MSVDAVGGAVEGAPARLALRVQYLGGHFFGWQWQPGQRTVQQCLEEATERIARHPVRYHAAGRTDTGVHASGQVVHFDTHKKLAPETWVRGLNSLLPDDIAVRAAAYVSDHWHARFTALWREYRYCIHNSTVPDLFVRAQSWYYPYCPLDSEAVAAALATLPGHHDFRAFRRAGSSRPHSLVHVYTAECTREGEQIAIRVRANSFLYGMMRLLIGALAEVGSGRWSVERFAGLWQAGNREQVKYAAPPQGLCLVGVGYPDDPFKTNGIGFARCHTGQEKPEARLGNGDLESREERPPHEMSPLH
217
Q8DRQ2
3.1.1.29
ACT_SITE 20; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSIDKVDDSVNYYLQEKKFEKTMQRYNG
127
P9WHH9
1.8.1.4
ACT_SITE 443; /note="Proton acceptor"; /evidence="ECO:0000250"
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
36
A0A8J1L0B3
2.7.1.11
ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MAQPDKRLFENLSGKGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVQAKVYFIYEGYQGMVDGGDNIEEVSWESVSSILQVGGTVIGSARCKSFRTREGRLQAANNLVQRGITNLCVIGGDGSLTGANLFREEWSGLLDELVQNGKIEAEATKQYAHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFIPEYPPEEGWEDTMCNKLSENRARKKRLNIIIVSEGAIDCHNKPITSDLVKDLVMKRLGFDTRVTILGHVQRGGTPSAFDRILASRMGVDCVLALLEATPETPACVVSLCGNQAVRLPLMECVQMTQEVQKAMDERRFDDAVRLRGRSFENNLNTYKLLSHKKNVSELPKSNFNVAVLNVGAPAAGMNAAVRSAVRVGITEGHKMFAVNDGFEGFAKGQIKEIKWGDVGGYTGQGGSLLGTKRTLPAKYFDQIAEQLRTHKINALLVIGGFEAYLGLLEMVEGRGKYDEFCIPMVMVPATVSNNVPGSDFSIGADTALNTITDAFESMVQLVEARGTYEEFCIPMCILPATISNNVPGTDLSLGADTALNAIMETCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEESFDIRELQANVEHLTEKMKTSIQRGLVLRNENSNENYTTDFIYQLYSEEGRGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAVQWISKKLVETYRKGRVFANTDDSVCLLGMRRRNLLFQPVTQLKDETDFKHRIPKEQWWLKMRPLMKILAKYKTSYDISDAGKLEHVNMCRRTDEAVAI
84
Q89X59
1.1.1.37
ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00487"
MARDKIALIGSGQIGGTLAHLIGLKELGDVVMFDIAEGVPQGKALDIAQSSPVDGFDAHYTGANSYEALDNAKVCIVTAGVPRKPGMSRDDLLSINLKVMEQVGAGIKKYAPDAFVICITNPLDAMVWALQKASGLPHKKVVGMAGVLDSARFRYFLADEFNVSVEDVTAFVLGGHGDTMVPLVKYSTVAGIPLPDLVKMGWTSQARLDEIVDRTRNGGAEIVNLLKTGSAFYAPAASAIAMAESYLRDKKRVLPSAAYLNGEYGVKDMYVGVPVVIGSKGVERVVEIELAGKDREAFDKSVGAVQGLVDACKKIAPDLLGR
5
Q55DJ8
2.7.11.1
ACT_SITE 1116; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MKSNYSTYLYKMSELERIVNGGDVSSIFIEQDDVLGEIKNFNYDLYTKYDSLVLKDPQTQNNSPKPPSLEIFILVNLIALCGRINDKFPNLDKFLTHYKYATNIFNLLSENIINSIEKFKETLSKDLPSFQLSVIANSSIVKKDNSIIKFLSCFGSFMKLESIEYFGSVFNSLIGEEDQFSLDLLQVLIDSSNEYKKFLQILEFNQLQKYYDDGHLCLFHSIKFDNLNEFKLLFNDSTWCQQQQQQQQINPQIFWFILCKYNSSKIAHYLLNDYQINKKSLKQKNPLEISPVTLLEIAFLCFSDKIAIVLFSQFNYHELLPKKSKMKHLIKSTSTLINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSKNIGLTQYTVLEGYFLINIRTRSRIAPFIEVLTMNGIHLTNDIIHTRIKSMSSDSIFRIFTEQYQQQQQNPLNNNQKQIQFNENFTRQQKIDFDNCPNEIDTFILDKTQCNLITLSQEFSIKVRAFTFYLSFGEIFTCSCEDYKREFSCKHMFFILLNYYHVPRNSYLIYQRQFTEIERYSIIMNIDLSKINSRIYGTPNFNTFFKIKSSPSSTTSPFQSINNNNNNNLNNNNNNNLNNNNNNENENKFKEDGDDEILQNLNRLNYILLRDFEFGPNDITTKLRETHINLFDRLLLIEDNLEALDKILKNFTQKGCTLSRDLVGDRNLLVLVAILDSTSKEKLSLLNKYWPLPEKTKKFAIPLIFFAISEECLKMFIQISPNLVKSTLNLHDWISILTEFALINETFLDHYPLLSAWYSDARSVETSLFRLFTCMDKIDCINYLIQTYLLPIPTFKNTLNNFETCYFFETYFLENSSIKAEQYLLEQELLEKKKQKEKKKQKQKQSKSKIINNPLSSSSSSSSSPSTSNTTITSTTPTTTTTTTTTTTPTTTTTTTTTSSPKQKPITPIKKEIEKEFEKIELTTPPPPLATTKQQQINENYDISIGKFKFNRKEENVLGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIEVLITLTNKNCYNIVRYIDQEEDESCVYLGLTLCDGSLQNLVEKGDNNLTLTQFLGYDINSSSKNNSRLLELIKDIVYGIQFLHQQGIVHNDLNPRNILIKDDRFIISDLGLSKMEVTSSYSFTMHAPTGQEGFHPAEVLLEKRKTKSVDIFSMGCILFYLMTGGQHPFGDKFYRIVNILTDKPILEPLKHNLVACDLISQMISKNESDRPTIEKILLHPFFWNHEKKVKFIDASLNLFKDSNGLFTSKLNKLINYQEINLKNNIDSSSSNNNNNINSNVINNNNNNNNGMATNIPFLSKPWNQLIDQTLIEHIINKQNQLNGVGNNKKVIIYSFDQVKDLVRCIRNTIQHHKEIQRLVRQSPSSNGDNKQEVLDCLESQELVLSYFEEKVPDLLLFLYQKFKKHLDSKSLIYFNDLIIK
99
P40081
3.1.3.48
ACT_SITE 11; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 13; /note="Proton donor"; /evidence="ECO:0000250"
MTGYPDVAAFDLDYTIWPCYCDTHLHGPFKPVKSSNGEVLTIICRDGYELTIYKDIPRILGDLKDNGVKLMTASRTWAPEIAQEILKIFKVKYAGVVTPLANLFDEFQWGERSKIGHLRDGLKDLYNTSDLKSKKICLFDDESRNKEVEKYGVKFVYVRDPENGPSWKLYQDYLSGKV
149
A0A1U8P061
1.11.1.7
ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MQFMLTIRASMEMKITVSFPTPNRCTLLILVLFSFAASPLHASLSINFYASSCPTAELIVSNMVRSASSSDPTIPGKLLRLLFHDCFVEGCDASVLLQGNGTERSDPANTSLGGFSVIDSAKSVLEIFCPETVSCADIVALAARDAVVTAGGPAFEIPTGRRDGRISDAANVRSNIVDTSFTMIEMIRPFNSKGLSLDDLVTLSGAHTIGVAHCNAFSDRFQMDSKGNLSLIDTSLDNTYAKELMKKCPSGSSASKTVNNDPETSFAFDNQYYINLLGHKGLFQSDSVLVEDERTSARVEAFANDQETFFQSWRDSFLKLTTIGVKTDDEGEIRQSCSFAN
14
Q4WHR7
2.3.2.26
ACT_SITE 1305; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MTRLRGASVGSYDAGVDRSQFHRSKLPSNAPDIIVQNTIDVSDPAQVLLWYREERRRQFNLLVRKYKNQLLHGCQDPDCRTPTCASYRRRVSEGPYRRYTELSARTLACYLASLDNPESGLCRNTQRLSSELSSHDHPRSSRRSSRGALTDLTEARSPSSVSSRRTPGDLPADRALLNQDTASAKPSDNTRIGSDSYTESRQQNVSAPVDGDSATQRMKDPKSFTQNLFDTLSLRMVEWLPLRRSPDVLDSDADRLGNQYVRSPKREGCEHTDTTVGSTCAKRRANLKNKSARVAPHTPSSQDASRRVPRVESKPEHQVKRISLIETDQHQQSPRTVKEGKSRLDLRPSRKLSYNSHLETDASVNIPSPPALKHRPQKHRGRNEHLDGSFTQAQRKKKERRVSWDSAKFLNDTQNQDAEKPLAARDSHLASETQSSNDDQLNFKSPYEKVERPLTVQTLSHLNSAIIDGLARMMVQSDEEAQRWRDELRYIESTGNFENPEWQFATWRQRRVYIFLAQSVFYALGSTKQILRSFREETAGPEQDYSKSKLDLQQLQPSLSKLFSFCPWDIALHSLWRAVEALFMPSKELSMPGRLSRRSSNNSTSMGPSSMPIVGRRTCDFEGHEHLADAKAADIATVAFFALTSSLPQVDSHTWRSLLQMRALGTVASSADMEKLSPTMAQSIVELTDKLEHELALRLVNRLVRALTARLAFYEISKARHPCLQDFSKKRQDSALDLLMNNLGDHYSLVRAGTDESDGAEPPPSAAVIIAEWLRTLFLKEWDGNPEISRSSSAGGVVEILSRMYKQRNRLGLVPEDFHTPFLCERLEPLDMPVEWIGRLTNNKTLHLLSYSFLFPPSALVIYFRALNYAAMSKYYEAAMTTSRHVNQTAFGPIPIQDDVMLLSQMKTSMSTYLVLMVRRDNVLTDALNQLWRRERRELMRPLKVQMGMDEGEEGLDHGGVQQEFFRVLMAEALNPSYGMFTMDARTRISWFQPCSLEPLYKFELLGLLMSLAIYNGLTLPVNFPVAFYRKLLGLKVKHLEHIRDGWPELTKGLELLLSWQDGDVGDVFMRTYEFTFEVFGAVETVDMEKVGRDAVWPLRARDRSKSSELATNWSELSQHADPADLSPPCSMSADHVDFLECGSSHRSKSERLDYCVPTPPVEEASLVTNDNRAQFVKDYIFWLTDKSIRPQFEAFARGFYTCLDRAALSIFTPEAFKTVVEGIQEIDLGELERHARYEGGFGPHHRVIQDFWSIVKSFSQEKKAQLLEFVTASDRVPVNGIASIMFVIQRNGVGDARLPTSLTCFGRLLLPEYSSKSVLEEKLNKALENARGFGVA
65
Q2R9B1
3.5.1.98
ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MATGGNSLPSPSCADDKKRRVCYYYDPGIAHIKFSDDHVMVPARVAMAHSLVGVYGMLGDMRRLRTRPATEAEIRRFHSPEYVDLLRDLTPESYFNDAALRQKAEDDHGIGGDDDCPAFDRLWKYCRGYAGGSFAAARALVDGASDIAINWSGGMHHASACKATGFCYVNDIVLAINELLGTFRRVIYVDIDAHHGDGVQNAFLDSNRVMTLSFHRYGKITPHKDFFPGSGAINEIGDGAGEHYSVNVPLDAGVRDDVYHTLFKPIVGKAMEVFQPEAIVLQCGADSLSGDRLGGMELSVRGHAECVSFLRGFNLPLLLVGGGGYTINHVASAWCYETAVAVGKERKLPDDIEIPSHGYELMYKNQGNKLHYKTSTATAARKRSSSTEVTKGKVLEHLSQVKRAPSVQFQERRGGDNAAGVGLYYERPPSLEDDEPAQRLHRLCFPGLTKRIRLND
184
A0A0K9PFB4
3.2.1.14
ACT_SITE 138; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MNFRSLFLIIAVTALATFNLSRISWAQTCGLQASGALCRDNLCCSEYGYCGHTSAYCCSGCQSQCSCGDGGDLGSLISESLFDEILLHRNDNSCPAKNFYTHSAFIEAANSFSDFGTKGDTTIRKREIAAFLAQTSQETIGGWKDAIDGPYSWGYCYKEEVNPEHNIYCDTSNILWPCAPHQSYHGRGPIQISHNYNYGPAGEKIGENILENPDLVASNPTISFKTALWFWMTAQSPKPSSHDVIIGAWIPSSDDIAANRLSGYGVITNIINGGLECGKGTNLDYRIGFYKRYCDIFQVSYGSNLDCKNQKPFNT
158
Q59638
2.3.1.12
ACT_SITE 520; /evidence="ECO:0000255"
MSELIRVPDIGNGEGEVIELLVKPGDKVEADQSLLTLESDKASMEIPSPKAGVVKSIKAKVGDTLKEGDEILELEVEGGEQPAEAKAEAAPAQPEAPKAEAPAPAPSESKPAAPAAASVQDIKVPDIGSAGKANVIEVMVKAGDTVEADQSLITLESDKASMEIPSPASGVVESVSIKVGDEVGTGDLILKLKVEGAAPAAEEQPAAAPAQAAAPAAEQKPAAAAPAPAKADTPAPVGAPSRDGAKVHAGPAVRMLAREFGVELSEVKASGPKGRILKEDVQVFVKEQLQRAKSGGAGATGGAGIPPIPEVDFSKFGEVEEVAMTRLMQVGAANLHRSWLNVPHVTQFDQSDITDMEAFRVAQKAAAEKAGVKLTVLPILLKACAHLLKELPDFNSSLAPSGKALIRKKYVHIGFAVDTPDGLLVPVIRDVDRKSLLQLAAEAADLADKARNKKLSADAMQGACFTISSLGHIGGTGFTPIVNAPEVAILGVSKATMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGELLADIRTLLL
54
A0A0K9NY36
3.1.1.11
ACT_SITE 416; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQNSNGYGQVNGGQKKQPVTMVIVSSLVLVAMVVAVAVGVSHYQKDNNNSGEPNKEPPNTSIKAIQSICQPTDYKETCEKSITSAAGSNTTDPKKLVGISFKVAMEHIHNVLAESKTMEELQKDPRNKKALEVCQETLEYSIDDLQRSLEKVDSFDLKKINTFIEDLRVWLSASSTFQETCLDAFENTTGDAGAKMKKAMNTTAELTENALAIVDGVSSILGNLQIPGLTGGRKLLGSMSLDPQDGVPSWLTDGKRKLLVDPNIKPDITVAQDGSGDFKTINEAVQRIPLSNATQFIVYIKKGIYKERVEISKKMINVMFVGDGQTATVITGNLNFIDGTPTFKTCTLAVVGNGFIGKDIGIENSAGAEKHQAVALRVQSDNSVFYRCQMDGYQDTLYCHSHRQFYRECTISGTIDYVFGNSETVLQKCIFSSRKPLSNQRNIVTAQGRKGPREPTALVLQDCSFVADPGLEPFKKQNPTFLGRPWKEFSRTIIMQCQIGDVIDPIGWLPWFGDFGLNTCYYAEYDNRGMGSVLTERATWRGIKTNGFGYDAAEQYTVENYLEGNDWLKTTGVPYFPGMLPVAHSAPANSGPVAGVVGPAGK
125
C6TCA1
1.11.1.7
ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MARVSPLFHSLLLISSLVLASQIHVSSGKLVPGLSWNYYLLTCPKLERIIRKHLEDVFEKDSGVAPGILRLFFHDCFPNGCDASILLNGDGDEKQHRANFGLRQEAIDAIENLRVLIYKQCLPVVSCSDILVIAAREAVRQLGGPDFDVPLGRKDGLGPNATAPDNLPAPFFRTDDLLRGFGNRGFDATDVVALSGAHTYGRAHCPSLVNRTIETDPPIDPNFNNNLIATCPNAESPNTVNLDVRTPVKFDNMYYINLLNRQGVFTSDQDIAGSPKTKEIVNQFASDQKLFFKKFSDAFVKVSQLDVITDRIGKGEIRDKCFVANKRRSSMASVVEEVVELAQEI
14
Q9X7R9
3.4.21.92
ACT_SITE 108; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 133; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
MSPFTAGPAPARTPRAEEGDTPATRFDDRLAEQLLDQRIVLLGTQVDEVSANRVCAQLLILSAQDPRTDISLYVNSPGGSVHAGLAIYDTMRLIPNDVSTLAMGFAASMGQFLLSVGTAGKRYALPNARIMMHQPSAGIGGTTADIEIQADNLDFTKRTIERITAEHTGQSPETISRDGDRDRWFTAEEAREYGMVDQVVQSLADVRPAATRRRMGL
179
Q97VX5
2.3.1.286
ACT_SITE 116; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MIYEKVAEELISSSYTIAFTGAGISTASGIPDFRGPQGLWKKYSPELASIEYFEKDPKNFWGFYSLRMRGLFEAQPNKAHYSLAELEKMGIIKVIITQNIDGLHQKAGSKNVIELHGTMRRSYCVLCLRTYDSLNVLSMIEKGNLPPRCDCGGIIRPDVVLFGEPVKNIYEALSIAYESDLVISIGSSLTVYPANLIPQTVKERGGKLIILNMEETPLDSIADYVVREPVEISLPKILENVRQKILS
58
A0A0D1CG83
1.1.1.37
ACT_SITE 202; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MFARQALRLAVPKAAAPRFFSSSTANNRAVAVLGASGGIGQPLSLLLKQNPLVSDLRLYDVRLAPGVAADISHVNTPSTTTGYQADQLGEALKDVEVIVIPAGVPRKPGMTRDDLFNTNASIVRDLAKKAAEVAPKAHLLIISNPVNSTVPIVAEVFKKAGVYDPKKLYGVTTLDVTRASTFLSGISGKKPSETIVPVVGGHSGVTIVPLLSQANGGDAVAKGEQYEKLVHRIQFGGDEVVKAKDGAGSATLSMAYAAAVFSDSLLKALNGEKGIKECAYVESPLYKDQGATFFASPVTLGKDGVEEIHSVGKVSAEEEKLLEAAIPELAKNIKKGVDWYAASP
5
A0A2R6WW04
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MMASKMYTRMLIVVVATLVFASLGDAYGYSGNHAGLRENYYSRNCPKAVSKISGLIKYYTKEDKSLPAALIRLHFHDCFVNGCDGSVLLDSTPTNLAEKDALPNKFSLRGFEIIDKVKEAIEEICPGVVSCSDILSLAARESISFKGGPRWRVPLGRRDSLSSIAEAANISLPIPTMNYDELVENFANVGLNERDMVILSGAHTIGEAHCAVVMPRLYNFPGSRDGVDPSLDRKYAETLKRKCPPGAELTLIPMDPSFGGQRFDGNYYRNIVSKKALFGSDNALIQDKDGRAIVSKSIISPKTFFREFGLSMEKMGRIAPLTGSQGEIRRKCSAVNPPAKYHRKSYEH
14
Q8ZNY9
3.1.3.16
ACT_SITE 80; /note="Proton donor"; /evidence="ECO:0000250"
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ
144
A0A3B6GW88
1.11.1.7
ACT_SITE 101; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATNKLAALVVLVAFLAGPAACEGINICLNFNGWLKPSILDPLFCPRGSGPPVPSPSGSGLSYGYYNTRCPTAEKIIKDAVKKAVDENPGIGAGLIRLFFHDCFVRGCDASVLLNTTNSQNSDTEREGLPNKDSLRGFEVIDEAKTAIEAACNNTVSCADIVAFAARDASYFLSNGSINIRMPGGRYDGRESFANETDQLPGPFSNVAQLQASFAAKGLTSDEMVTLSGAHTIGRARCMFFSSRFSEMDPAYAAKLRAECNGNGNTNMNQDDVTSNVLDKQYYQNVLDNKVLFASDAVLNSTVTRAQVTENADKAGEWERKFEKAMEKMGKIKGDQQGLEIRKVCWRVNNVGLY
14
P23566
2.3.2.23
ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
MSTTARRRLMRDFKRMQQDPPAGVSASPVSDNVMLWNAVIIGPADTPFEDGTFKLVLSFDEQYPNKPPLVKFVSTMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNNASPANAEAAQLHRENKKEYVRRVRKTVEDSWES
64
D8QY72
2.1.1.37
ACT_SITE 1140; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016"
MAVHRGRKKRLKNNAAAPAARNPPRSDASHHSDSSDVEIISVTAFHNTGSGCKRPRPRRAAIKNLEEKEDEEEAIEAENVIEVKPEPRLADSEATAIMRTREGGEGKKEKPQRRLLDFVVHDGQGAEQPIEILETVPLFVTATILPVTGLLEKQRGFRCESFGPLESWCISGYEDGVLVVWICTEAGDYICCKPAASYKTWYSALADKSSLCIAVFKALSKPDGGDPELPLESLVAQVARRSKKTALSQPFSREYLISIGGFVSSQLKAMDVSASDGDQVFTGLPALVALEKESASCRMEDVSLASHGRKNGTLTINEPDGSNPSSEHSSGLTDQYAGDAQYAQLLQEREERAMRMRSGGAKAKSYIKINEDELAVDYPLPEFYKPEEEETDEYLVMSGDDGELEHRMLYDWALYNSDMRFVSLELLPMVSGAETDVEVFGSGLVTEDNFEYCMDNEPDDAASTTHNENLLRVYLSSIKEWKIEFGAKILSISIRTAGAWYRLGPPSAQYAAWYSPVLKTARLARHIITMLKVVSRVSRLSFPDVVKRLTDQTQDSDTFVGSKVADVERFVVVHGQILLQQFSEFPDDTIRKSSFVTGLLKMMEERHHTKLKVSKKKLLRGRNLNPRGSLQPDASKTKPMRATTTQLVNRIWSDYCSTYNEDGTCEPEAENVRRQQDQKADAKAIRGHLIKPGEAVGYEVEGAEDAFLLVEYLYKANGRSMVHGRVLVKGESTVLGDAASKRELFLTGSCDNVEVRDAKEIVKVELRRRPWGHMHRKDNATADEEERERARDREIKGLPTEYFFQALYVPEKGGFFRIPHDKLALGTGVCEGCKSREEAKTKDSLSLFANLQGFRFQGVEYHINDFVYVDITQIMTQSQDEIQKFKGGRNKGLRAFTICQLMDVIPSSKTGAEQLTVRKFYRPEDVDLGKAYKADVHEVYFCERTTTISLAAVRGKCTVVKRQEFTVASETKALMDLFFCSCVYDPLKGTVKQLPANVKLGKPPVASSLASAKGKGKLVEDDRQPKETSANDEKLSMLDIFAGCGGLSEGIHQSGIASTKWAIEYDHAAAEAFKMNHPTATVFFDNCNVVLRSIMEIGGDLDDCCSTPEAAEMASKLSENQKSSLPRPGEVDFISGGPPCQGFSGMNRFNKRNWSKIQCEMVLGFLSYADYFRPRYFLLENVRNFVSFNKGQTFRLTLASLLEMGYQVRFGILQAGHYGISQSRTRAIIWAAAPDEVLPDWPEPVHVFASAQLKIPLSGNSVYAAADDTRGGAPLRSITVRDTIGDLPPVANGTEKPETPYGNEPQSWFQKNIRGGATVLRDHICKEMNELNFIRCQRIPKRPGADWRDLPDEKVKLSTGQTVDLIPWCLPNTAERHNQWKGLFGRLDWDGNFPTSITDPQPMGKVGMCFHPEQDRIVTVRECARSQGFPDSYKFFGTMQNKHRQIGNAVPPPLAKALGVKLKEAIRQASS
47
A9T961
4.1.1.50
ACT_SITE 82; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 96; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 245; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 258; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MGVSFQNDTGAVAGSVASPGFEGFEKRLDIEFHIPPIFSDPAGQGLRAIPRTELDQMLRAAECTIVSHMSNAELDSYVLSESSLFVYPHRLVIKTCGTTQLLRAIPILLQVTSRLNLRVSRVKYTRGTFMFPAVQPYPHGSFTEEVRYLEEYFGSLGDGGKAFVMGSKGKFPNWHIYTAADHGATAEPTYTLEMCMTKLDRQAAGNFVKAPGLETGPEMTKVANIDNILPESRICDFAFDPCGYSMNGIEGAAHSTIHVTPEDGLSYASYEAMGYNPRRVDLPMLVERVVASFKPAVLAMSVHVSDANKATHTSGSWDESLCPKGYICDGSSRQELPCGGIVVFHTFKEITFSTVKEVSMFAEPLPLFRGAAGVSKGCKKVAVKKNKVNRG
196
Q5KKM8
1.1.1.8
ACT_SITE 255; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1"
MSAASTAPSSPEVVQQFSDLDIGSTVTTPAVTRPSSPSPPSLPPSPLSSGKHKIAVIGSGSWGTALAKIAAENAWRRKEDFHSEVRMWVREKIVNGKPLTHVINKTHLNSRYLPDVVLPRNLVAVPHLKDVVKDATLIVFVVPHQFLHTVLNELARPGVLLRGAKAVTAIKGVEVNGTDIQTFASLIEAKVGLPCSALSGANIALEVAMGQFCETTIGCPTPDQSLLWHAVFNSPSFRVNTVEDVSGVSLAGALKNVVALAAGMVDGLGLGGNTKAAIMRIGLKEMTQFCLEFFEGVRPETFSNESAGVADLTVTCFSGRNRKCAEEFVRSGQPFDVVEKKLLNGQKLQGTATAEEVNAFLFARKRAHAYPLFEKVYKIAFEGMPPKNLVVGL
7