Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
B9GXZ7 | 3.1.1.11 | ACT_SITE 430; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDSINSFKGYGKVDEAEQQAFRKKSRKRLIIIVVSSIVLLAVIIGAVIGAVVHKRNNKSSSNPVPPPELTPATSLKAVCSVTQYPASCFSSISALETGNTTDPEVLFKLSLRVAMNELSKLKDYPDKLIQSIKDTTLQGALKVCATVFDDAVDRLNDSISSMAIGEGEQILSPAKMNDLKTWLSATITDQETCLDALQELSTTKHFNQTLVDQVKTAMENSTEFVSNSLAIVAKILGLLSDFKIPIHRRLLGFERSHISEFPQWVSFGDRRLLQESKPTPNVTVAKDGSGDCETLREAVGKIPKKSESKFIIHVKEGVYV... | 125 |
P9WI73 | 2.7.11.1 | ACT_SITE 276; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRT... | 99 |
B7PDB8 | 2.4.1.18 | ACT_SITE 337; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 392; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MEVPEIGNLLDLDPYLKNYEQEIRRRYKCFSDRLTEIENVEGLLRFCKSYEEYGIHCLPDNSVRIREWAPGAEALFLRGDFNGWERLTHPFKKLPFGKWELTLPPKPDGSCPIDHLSRIKIVVLDRTTGQLADRNSPWATYVVRGKDAPQYEQRLWNPPPEERHQWKHPKVAAPQSLRIYECHVGIASEDYWVANYSYFTSHVLPRIKAQGYNAIQIMAIMEHAYYASFGYQVTSFFAASSRYGTPEELKALVDAAHGMGLYVLLDIVHSHASKNVLDGLNRFDGTDACFFHNGGRGHHPLWDSRLFDYTKLEVLRFLLS... | 73 |
A8WWX1 | 2.7.11.25 | ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:O43318, ECO:0000255|PROSITE-ProRule:PRU00159" | MDTSPHSKPSSSSASQSSHSPSPAPVTAPRKTRDSGLCMTQDIPEIPTHCIDNLNSHQLGRGTYGIVEKTRYRRSRNHEYRPAAIKYSSPIHLATLIREAKVMWALRDHSNIIKIYGLYRDARHGQGVVMEYMDCGSMSELIYDRKSIDYTIDHVASWLYQMASAVNTFHRNDQVHRDLKLQNMLLCDRYRTMKLCDFGTFTAMHQSMTSNRGTPITMAPEVFRCEEYNQKSDIYSIGIIMWQMIARNHPYNRNLSVPGLLYNVATASLRPPELDCNPILSDFYKQCWHDDPVSRPTAAECLQYFTALKTEYPNGNVPLA... | 105 |
K7LFL7 | 3.1.1.11 | ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTMMGKTLLLTLLLLSSVFSIASSRRRHSNNSNIDWWCNQTPYPEPCRYYIKHSHYQHKQLKHKSEFRTILVHLALERAVIMRRKARELGGNGVTKKQKSVFRDCLKLYDNTVFHLNRTLEGLHVKTSCSPFDAQTWLSTARTNIETCQNWALELGIRDSMVPAERCNLTEIISNGLFVNWAFLKYREAHYTADAEEDALFPRWFSMHERKLLQSSSIRAHLVVAKDGSGHFRSVQAAINAAARRRLKSRFIIHVKRGVYRENIEVDKTNDNVMLVGDGMRNTIITSARSVQAGYTTYSSATAGIDGLHFIARDITFRNT... | 125 |
A0A078IT96 | 1.11.1.6 | ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 175; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MELTLFNHYSTQSNPINANDSVSSISLCWFLEVLWRFIYVITYRPASSYNSPFFTTNSGAPVWNNNSSMTVGPRGPILLEDYHLVEKLANFDRERIPERVVHARGASAKGFFEVTHDISNLTCADFLRAPGVQTPLIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNIPVFFIRDGMKFPDMVHALKPNPKSHIQENWRVMDFFSHHPESLNMFTFLFDDIGIPQDYRHMEGSGVNTYMLINKSGKAHYSLLEEDAVRNIDNFFAENEQLAFCPAIIVPGIYYSDDKLLQTRVFSYADTQRHRLGPNYLQL... | 13 |
A0A059B4H6 | 1.11.1.7 | ACT_SITE 42; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | PLKVGFYQKKCPSAEAMVRESVQKALAADPGAVAPLIRLHFHDCFVRGCDGSILLNSTKGNTAEKDSMGNLGIGGFEVIDDAKAKIEAQCPNTVSCADIVAFAARDGVRAAGGLHYAVPSGRRDGRVSLASEVIQNLPGAFFDAAQLKANFAKKGLSLRNMVTLSGAHSIGDSHCSQFTKRLYSFNSTYSQDPSLNPNYAHLLKTKCPRNSPTDPIVPFDPVTPNVLDNAYYRNLKSDKGLLYSDQVLWDAPLTRGLVKDNANHPSAWARRFTAAMVRMGSIEVLTGTQGEIRKNCRVIN | 14 |
M4D3N5 | 2.7.1.11 | ACT_SITE 282; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MDSYRFIKSSSKQSTSSETDHHHHQFGSLIPRLGRKYRSLSFDSGLLLIVNQRFESPTRLVMATSALNSDKKIVTGPAGYVLEDVPHFSDYIPNPPTYPNPLQDNAAYSVVKQYFVDEDDTVPQKIVVHPDSPRGTHFRRAGPRQRVYFDSDDVVACIVTCGGLCPGLNTVIREIVCGLSYMYGVKKILGIEGGYRGFYARNTIDLDLKTVNDIHKRGGTILGTSRGGHDTTKIVDSIQDRGINQVYIIGGDGSQKGAAVIFEEIRRRGLKVAVAGIPKTIDNDIPIIDRSFGFDTAVEEAQRAINAAHVEATSFENGIG... | 84 |
B7PPL7 | 3.4.25.1 | ACT_SITE 25; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MNAFNCPDLSDVVPDFLKAEHSTGTSTIAVEFDGGVVLGADSRTTTGYVVQPTCILGRQCDFCISCRTESLKDNALLFDILNYFAECNRHLSRMELGEPPQVETAASVFRELCYNYRDQLLAGIICAGWDRKKGGQVYVIPLGGMMLRQPVAMGGSGSTYVYGYVDAHFKKGMTKEECLEFVTNTLGLAMYRDGSSGGVIRLAVITKDGVERKVLTGDEIPKFYQD | 180 |
Q81JD0 | 5.6.2.2 | ACT_SITE 125; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MMSDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIVLPARFPNLLVNGTTGIAVGMATNIPPHQLGEVIDGVLALSHNPDITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRGSIMLRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRNGMRIVMEVRRDANANVLLN... | 222 |
O86776 | 5.4.99.12 | ACT_SITE 63; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MSDEVEAGFVRVRLDLSYDGSEFSGWAKQAGGRRTVQGEIEDALRTVTRSRETYELTVAGRTDAGVHARGQVAHVDLPREVWAEHHVKLLKRLAGRLPRDVRVWALREAPSGFNARFSAVWRRYAYRVTDNPGGVDPLLRGHVLWHDWPLDVDAMNAAARGLLGEHDFAAYCKKREGATTIRTLQELSLVRGEDGIVTATVRADAFCHNMVRSLIGALLFVGDGHRGPEWPAKVLAAGVRDSAVHVVRPHGLTLEEVGYPADELLAARNKEARNKRSLPGAGCC | 217 |
I3KFN7 | 3.5.1.98 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | SGDIAFRMTNRTSYFYDPDVGNFHYGAGHPMKPHRLSLTHSLVLHYGLYKKMMVFKPYKASQHDMCRFHSEDYIDFLQKVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNHKICDIAINWAGGLHHAKKFEASGFCYVNDIVISILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYRQLFQPVIKQVVDYYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEFVKSFRIPLLVLGGGGYTVRNVYFEYFAPDFT... | 184 |
E9HG29 | 3.5.4.5 | ACT_SITE 69; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MGDCDEEVDFDLLDPAIQKIINKAKAVREKAYCPYSKFAVGAALLCDDGAIIDGCNVENVSYGLTICAERSAICKAMSEGQKVFNSIAICAEMKDKFVGPCGACRQVLAEFNVNLDVYLCKPNNEILKTSMAKLLPLSFTPNWVSFSS | 187 |
A0A1S3YI46 | 2.7.1.11 | ACT_SITE 310; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MESLSPAIGQKAILRYTTTYSYHDLFLSSVRLRTVRNPNRVSRRLRIRVQAKSGAFENSAAGGGCIDFSDPNWKLKYQREFEARFNIPHITDVFPDAVEYPSTFCLKMRTPVSEEFAEGYPSDEKWHGYINNNDRVLLKVINYSSPTSAGAECIDPNCSWVEQWVHRAGPREKIYFKPEEVKAAIVTCGGLCPGLNDVIRHIVITLEIYGVKKIVGIPFGYRGFSEKDLAEMPLSRKVVQNIHLSGGSLLGVSRGGPKVSDIVDSIQERGINMLFVLGGNGTHAGANAIHDECRKRRMKVAVVGVPKTIDNDIMLMDKTF... | 84 |
O94324 | 2.7.11.1 | ACT_SITE 652; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTNPEQLKRILSHEVLLKIEMSKNGIVEYANPAFFELIGYEGDLFQCSFYEYLQSDDEHLMKKATDNLFRKSISVAHVFAFLRCNPIRSPNYYIQQAKAPFEGKTYIRMLFRGILVDSLYGKDTRVLWAGKYLYPQRSVINEMDFILFNTLGIGAFILHDHLLGIIKYNYIHVPPPSGKLCSLCEDNLPEWYFEVHSDFCLVWNDLVRRVFAVQQLINCKKLEIEDIVNKLPTGSNHMVEETFLSLPVITVFNGKKNRKQRFRIRSWRSSLNFLVKELDKSIKNFAYLEHRTFLTISNSAAKDMKREIYEKSLVNWEYDF... | 99 |
A0A0D1E476 | 6.2.1.5 | ACT_SITE 283; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MFKHAAASLSRPLARGFSSSAARASYEDTIKNLLINKDSRVICQGFTGKTGTFHCQQALEYGTKLVGGVSPKKAGQTHLGLPVFGSVKEAVRETKPHASVLYVPPPGAADAIIEAIENEVPLIVAITEGIPQKDEIRVAAALRSQSKSRLVGPNCPGIINPEGCKIGIMPGHIHTPGRIGIVSRSGTLTYEAVNQTTQVGLGQSLCVGIGGDPFPGSTTLDLVKLLLDHDKSEGIVLIGEIGGSMEEDAAEYLAKYNKTRANPKPVVAFIAGRTAPPGRRMGHAGAIIAGGKGGADDKVKALTEAGAIVADSPAKIGALM... | 247 |
A0DMT8 | 2.7.11.1 | ACT_SITE 277; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MNYPYQPYRPYQRLPNSSVHNPNIMSYVDQVLSKSRTNYGSVQQDQQPKYQTYQTNSIKTDTDLKSIGNSPLILPQKSLVIQPTLKSKQEYLFPKKVESLSFQSDIPPIIPLIPLMSDVREQYTKKQVSTPISQASSPMKKPENQKQKYKNFTIIKKLGDGQYSEVFVAKHTQTGFLVALKVIQKSQIIKENMQAQLAWEIKIQYLLEHPNITKLYTFFQTPTEIVLVLEYCSHGQLNTLQQMQPMKKFQERVAAQYVQQITFALMYIHNQDVIHRDIKPDNILLSFGQVKLADFSFCVYSPDEERQTQCGTIIYASPQI... | 99 |
A0A380PL54 | 3.1.3.3 | ACT_SITE 117; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 119; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MSNSLTYCDLPSEIYQWPGLPLSLSGDEVMPLDYRAGHTGWLLYGRKLDKQRITDFQRQLGAAMVIVSAWCVEDYQVIRLAGSLTPRIKTLADESGLDVAPLGAIPHLRTPGLLVMDMDSTAIQIECIDEIAKLAGVGDEVAAVTERAMQGELDFSASLRQRVAALKGADANILKQVRDDLPLMPGLVSLVRKLQALDWHVAIASGGFTYYAEYLRDKLRLVHVAANELEIKDGKLTGCVLGPIVDAQYKADTLIKLAEKLNIPLAQTIAIGDGANDLKMMQVAGLGLAFHAKPKVYAKAKVAIRHGDLLSVLCILTGSL... | 147 |
Q9HQS4 | 5.3.1.1 | ACT_SITE 85; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MFVLVNLKAYPCDPVAIAEAAADVAETTPATIAVAPQPADIGRVADTGATTYAQHVSPTEHGSHTGSVLAESVADNGAVGTLLNHSEHRRRLADIDGSVAAAERAGLDTVVCANNPAQVAAAAALGPDAVAVEPPALIGTGTPVSQADPDIVSDAVAAAEAVDPSVDVYCGAGITTGEDVVSAGDLGASGVLLASGVAKADDPRAALADLVAPL | 213 |
A0A7M7PPY0 | 2.3.2.26 | ACT_SITE 766; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MPSISQVFTMPNPSVRREGPMKLRLTVLCAKNISKKDFFRLPDPFAKVVVDGSGQCHSTDYCKGTLDPKWNQHYDLFLSLSDSITLSVWNHRKIHKKQGAGFLGCVKILSHAIQRLKDTGYQRLDLCKHKPEDGDNIRGQIVISLTSRDRVGSSASGAVVDSRNINPHPMLPSDPNELPDGWEERMSTSGRVYYVNHLTRTTQWDRPTRPAVECTQSQAPSSRTSTHANGHHNNHHHHSSTSSTSSQPHHRGTSHGDRGGGGGGSGEGHEGVRPGASSRHGGPAPSEEQNKYTRRATSRMRNYMNRSTLHRVIDLPEGYE... | 65 |
Q20296 | 3.5.1.98 | ACT_SITE 146; /note="1"; /evidence="ECO:0000250"; ACT_SITE 561; /note="2"; /evidence="ECO:0000250" | MLFEDRQKNRSTGPTLIGFNQTQNEHENTVCPTHPESSDRILKIKEALTKTKILEKCTVLTNFLEIDDADLEVTHDKSMVKDLMESEKKTQEDINSQCEKYDSVFMTENSMKVAKDGVACVRDLTNRIMANEASNGFAVVRPPGHHADSVSPCGFCLFNNVAQAAEEAFFSGAERILIVDLDVHHGHGTQRIFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSIIFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVLEGGYNHQIS... | 184 |
B9RR23 | 3.1.1.11 | ACT_SITE 382; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFSLLNLLLLLFFFSPIFFSSAWAANISSSSSANSLDTHLSSLRNFCSGRPYPDACFDSLKLSISINISPNILNYILQTLQTAISEAGKLTNLFSSAGSSSNIIQKQRGTIQDCKELHEITLSSLKRSVSRIQAGDSQKLADARAYLSAALTNKNTCLEGLDSASGPLKPVLVNSVISTYKHVSNSISMIPSPNSEKGQKNRRLLGFPKWLSKKDRRILQSDDGDEYDPSEVLVVAADGTGSFTTITDAINFAPKNSFDRIIISVKEGVYEENVEIPSYKTNIVLIGDGSDVTFITGNRSVDDGWTTFRSATLAVSGEG... | 125 |
A0A3Q7GMX0 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDSKGFNCSVFVLVCCLVLSLSVSSLAKRQPSCLIEVGYYRYTCPSAEAIVRKVVYKAVARNPGIAAGLIRLHFHDCFVRGCDASVLLDGLNSEKESIANKNSLRGFEVIDEAKKQLEAACPGTVSCADILAFAARDSSYKVGKINYDVQAGRRDGHVSIKDEALANLPSPFVGVKELIKSFARKGMSVDEMVTLSGAHSIGVAHCAVFANRLYPQNKQQNLPIDRVYERMLKSICPPESLTNGTGVANPTNFDVITPNKLDNKYYMDLKSNKGLLVTDQTLMSDPKTAKMVNFNARYGRVWGKKFADAMVHMGTLDVLT... | 14 |
B3RY08 | 2.7.12.1 | ACT_SITE 450; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | VASSSDFLFKLAVFSYKVLHWNLSNLTALLNLTSTRYLKMLHVYTLDMSRYMKITPKRVRYVKDHERKLYSCLLEITSEKEKEFNEAINEAVQGWSSSIVEKVINVEIPNDFLNKDNKPKTWVQLQHITKFVEKIVYDELYKKISSKIVASIKLLQESFTGTLKRCVEHLEVNNNNQPADHEVIRASRALKEFLDVAYEVDMPVSHTTSIIKVVLDEIKSTFKSIRRGDLPVIDKKWKSNIALEALQSINISQFTKQASNHLKQRIKKSHETFTAALTMLENRHRTRITTTEERLSEVRTYYAPTLARLSLTSTSLYHLC... | 107 |
F6HSM4 | 3.4.21.92 | ACT_SITE 160; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 185; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MERSLTLTYAASASRPLCFNRSPSSSSLWLPSTSRSSRKGRAVSMVKASSASRPTLASNWDLSSLQSASAPTWLPRFEDLDTTNMLLRQRIVFLGSQVDDMTADLVISQLLFLDAEDQEKDIKLFINSPGGSVTAGLGIYDAMKLCKADVSTVCLGLAASMGAFLLASGSKGKRFCMPNSRVMIHQPLGTAGGKATEMGIRIREMMYHKIKLNKILSRITGKPEQQIEADTDRDNFMNAWEAKEYGLIDAVIDDGKPGLVAPTADAGPPPKTRVWGLWKVEGSRKAKKNLPSEHKLLQNGHQGGDDEKGTEQEKEASSPV | 179 |
A0A6I8PJE5 | 2.7.1.11 | ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MNESAPGEETDPRHTTAHACEYTSVCNHVQRKPTQLPNSDSSPSVVFTERLLRADHRTQRLGGYSTTGLADDVSFHPPAPPPTRPQHPGVPLAHLGPLPLSPPPGMNAAVRAVVRVGIFTGARVYFVHEGYQGLVDGGENIREATWESVSMMLQLGGTVIGSARCRDFRTREGRLRAAANLVKRGITNLCVIGGDGSLTGADTFRAEWSGLLTDLQKSGGITAEEARRSSHLNIVGMVGSIDNDFCGTDMTVGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTALACGADWVFIPESPPEDDWEEHLC... | 84 |
A0A8M6Z2U3 | 2.7.11.25 | ACT_SITE 331; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50" | MHTHSTMGSSPEVLSWTSCPSLLVGKLKEELKLTVVGDSIKKPNNNISPQALLPPAPPPPPPPPQIITDLAPPTTLPMPLHHLQLPVRDEEPGGTSPPCTALSEDSTREQGHFENSVLQLQEQEDAETPGSCGQGGCGSGGEEKNEENGCPMEHSGDDTHHHPHDDIKLHFHRAGTGSGGFLEGLFGCLRPVWNIIGKTYSTEYKLQQQVEMWEVPFEEISELQWLGSGAQGAVFLGKFRSEEVAIKKVREQKETDIKHLRKLKHPNIISFKGVCTQAPCYCIIMEYCAQGQLYEVLRAGRKITPCLLVDWASGIASGMN... | 105 |
F0ZP67 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MGLLKAGSIAPDFICKNQDGVDVKLKDFSDKPLVMFFFPSNIGMICTRENIEFKENYQKFIDANCHVVGISGDKIKKQKKFHCKNDLPFPLLIDRKRKIEKAFGAHFSRATFVIHNGEIVLSHLTHWFTSKSHIEESLKVVEFLNGNK | 12 |
D8QSL1 | 2.7.11.25 | ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MPSHSPIRWQKGNLLGVGSFGRVYKGFSDSGTFCAMKEVLVVDDPKSIESVKQLMQEINMLSSLRHPNIVQYLGSEMLDDSLYIYLEFVSGGSIHKVLQEYGAFKEPVIRSYTQQILSGLQYLHSMNKVHRDIKGANILVDTNGEVKLADFGMAKHISSSSLVLSFKGSPYWMAPEVCPRFLSSNTSMTPYPVDIWSLGCTIIEMATGKPPWSQYEGIAAMFKIGNSKETPTIPDTLSPVAKEFIRLCLQRNPDDRPTASQLLEHPFVKFLHDEHLPDGLPPLSPTFRSVVRDILCFPFFCFFWMMLSDQPA | 105 |
A0A0K9NR24 | 2.3.2.26 | ACT_SITE 995; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFFTGDSSGRKRVDLGGRSSKERDRNVLLEQTRFERQKRLGLKKQIAAAIIIQKCFRGRKCVEKERSKIRREFINNFGECHLKFDLNCFSPQSTFLRHLLFFFQTSNQGDFYILVETCQKLLQSIKDGGDLISIIANKEYKENHAVVDNRLRQLSYFCIQAVHQNRNELKEQLLMGANLSSMPAIILLETIFTLTSPRLPWGNNIMDALIRKNVFSMLRDLILCGTDSQKSMGSLRAVSSMEHVIIAFASYKGHGHSYNPALNFTTQILSIPLLWHRFPYLKEVITGELSLHYVTEWAQCLHSNAIDFPGDVSPEFPGYA... | 65 |
P52486 | 2.3.2.23 | ACT_SITE 92; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MANMAVSRIKREFKEVMRSEEIVQCSIKIELVNDSWTELRGEIAGPPDTPYEGGKFVLEIKVPETYPFNPPKVRFITRIWHPNISSVTGAICLDILKDNWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVAYQFKDKYDLFLLTAKHWTNAYAGGPHTFPDCDSKIQRLRDMGIDEHEARAVLSKENWNLEKATEGLFS | 64 |
Q9LEW0 | 3.4.19.12 | ACT_SITE 186; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092"; ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092" | MSARISFLKNPDPCNHLSDYKLRYGTDGYKSFNNLFRCFNDARIKIKLQGIDIPRCSYCSVYQKRLYICLICRSISCSSHILLHTQLNKGHDIAIDVERSELYCCACIDQVYDSEFDEVVVSKQLFGLGMSVKSGADVVAVRSNKKRRLDSQLIIGSNFLVSPRDRREKWTFPLGLRGLNNLGSTCFMNAVLQALVHAPPLRNFWLSGQHNRDLCPRRTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFISLLDRIHENEGKSKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGST... | 175 |
P57384 | 1.2.1.12 | ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2" | MTIKVGINGFGRIGRVLFRLAQKRSDIEIIAINDLLAPEYIAYMLKYDSTHGVFKKHITFDKDNIIINGKNIRVTSIKDPEKLMWHDLSIDVVIESTGLFLKREQAYKHILAGSKKVVVTGPSKDDIPMFVRGANFHKYQGESIVSNASCTTNCLAPLSKVIDDNFGIIEGLMTTVHASTATQKIVDGASDKDWRGGRGALQNIIPSSTGAAIAVGKVLPNLNGKLTGMAFRVPVSNVSVVDLTVRYKKSATYSEICQKIQQASQKEMKGIMGYTEDEVVSTDFNGEELTSIFDAKAGLSLNKNFVKLIAWYDNETGYSS... | 22 |
A0A8V0XPF0 | 2.7.10.1 | ACT_SITE 846; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MGCCDARGLLWRFGLFLPLLTARPAAGGHGASNQVVLLDTTAVLGELGWKTFPLNGWDAITEMDEHNHPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVVGTCKETFNLYYMESDESHGLKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEVREVGPINKKGFYLAFQDIGACIALVSVRVYYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSVGYEELDGSCHACRPGFYKAFAGNVKCSKCPPHSSTYVEATSVCQCEKGYFRAE... | 97 |
P34923 | 1.2.1.12 | ACT_SITE 156; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10009" | MVGSAKIKVGINGFGRIGRLVARVALERDDIELVAINDPFITPEYMTYMFKYDSTHGQWKKTEVTLHSEGHLTFGGNPVAVYACRDPSEIPWGKHGADFVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVMGVNENKYSDEDIVSNASCTTNCLAPLAKVINDKFGILEGLMTTVHATTATQKTVDGPSSKDWRGGRSAATNIIPSATGAAKAVGKVLPELNGKLTGMAFRVPTTDVSVVDLTVRLEKPASYDAIKTAIKEASEGQMKGILGYTEDDVVSTDFITDSRSSIFDAKAGIALSDTFVKLVAWYDN... | 22 |
A0A7I4B3X1 | 2.3.2.26 | ACT_SITE 1289; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MITGTMQHVPRVTKVRQVSLGGASARELTRDELLGRVAQQRAVRSFGKQATASALLIQRVWRGRTIARQAAAQARTDWDKQFFLRHGEYQNPISADAISNQMLRPLFMFLRHSSCFDLHQTQEGAEDAGRLATCFRVLLQSIHNPDMRYNYCDLSVGFPDKMSKWIYQARQLLRLACAALGKKGHEFEPKASDNNHITLEASNLAGLAIRVIIGLTDSGTWKCFDEPGQEFRKRKAHLVVLGLLEWLASGSGGLYLAVQSYILANFPVPGIKDDHARSRGKKDKFIITASIITITLRPLLVLSAECSRDRDDEKTFEDKD... | 65 |
A0A804J4T3 | 1.11.1.7 | ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MELLCIILLSLSIPFAIGDLQVGFYNSSCPQAESEVLSVVSKHFATDHSVTAAFLRMYFHDCFVRGCDASILIAPTKKKKTERSAGPNLTVRGFEIIDEVKANLEAQCPSTVSCADIIALATRDAVALAGGPNYDIPTGRRDGLVSNPKDVRLPGPSLTVSGAFQFFSAKGFTLEEMVILLGSHTVGVAHCVFFRDRLGNFQGTGAPDPSMDPSLKAKLTRICGPRPKPLKKDPTAFLDQNTSFVVDNQYYNQLLVNKGVMQIDQELASDSSTASVVSGLASDEAGFLQKFADALVKLGNVEVLMGTGGNIRKKCTAFT | 14 |
B7QIA7 | 2.3.1.48 | ACT_SITE 323; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | GHLSGKFATHGTLECCPLYHNTTAADCETNLTLFDRTKVEVCPMQGRKAALKKGSFYHHVEVEGSDSFVDLSFVVLALLPQKYLPGGRTSPSLIHARNADREPDLSNLTPFYDLDMFREAQARAAEEMDGPARARSQEDQRASLRWQRTGGIRTLEMGRYEMDVWYSSPYPEEYQCLAKLYLCEFCLKYMNSHTILRRHTAKCVWRHPPGDEIYRKGSVSFFEVDGAKNKAYCQNLCLLAKLFLDHKTLYFDVEPFLFYVMTEADAEGCHVVGYFSKEKNSFLNYNVSCILTLPPYQRQGFGRMLIDFSYLLSKVENKVG... | 61 |
A0A1U8LM42 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEPSYIFLTMAVTLLSMPPTGFGQGTTRVGFYSKTCPRAESIVKSTVESHFRSNPAIAPGLLRMHFHDCFVNGCDGSVLIDGPNTERKAVQNSLLRGFDVIDEAKAKLEAACPGVVSCADILALAARDSVVLTKGINWKVPTGRRDGKLSLQSDAAKLPGFTDSIESQKQQFARFGLNTQDLVTLVGGHTIGTAACLVFNYRLNNFTNGGPDPTINPSFLPQLRSLCPQNGNNFRRVDLDTGSANKFDTSFFTNLKNGRGVLESDQKLWTDASTRTFVQQFLGEKGVRKLNFGKEFAKSMVKMSNIGVKTGSNSEIRRVC... | 14 |
Q9FC99 | 2.7.1.11 | ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01976" | MRIGVLTSGGDCPGLNAVIRSVVHRAVVDHGDEVIGFRDGWKGLLECDYLKLDLDAVGGILARGGTILGSSRVRPEHLRDGVERARGHVEELGLDAIIPIGGEGTLKAARLLSDNGLPIVGVPKTIDNDIAVTDVTFGFDTAVTVATEALDRLKTTAESHQRVLIVEVMGRHTGWIALHSGMAAGAHAVVVPERPFDIDELTAKVGERFSAGKRFAIVVAAEGAKPKAGTMDFDEGGKDVYGHERFAGIARQLSIELEERLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGEFGKMTALRGTDIEMVSLA... | 84 |
A0A061E3B2 | 1.11.1.7 | ACT_SITE 108; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMWHNFETNGGTKPGLGISVGSLKAKDPSRLKRLKPSHRMEGIYSKQKFFLVFVLFHMVATLVKGQGTRVGFYASSCPLAESIVSSAVQSHFQSDPSVGPALLRMHFHDCFVHGCDASILIDGPDSEKKAPPNLGVRGYKVIDDAKAQLEATCPGVVSCADILALAARDAVVLANGPKWEVPTGRRDGMLSLASDTDTLPGFSESIEEQKKKFAAFGLNTRDLVTLVGAHTIGTTACQFFSYRLFNFTAVGNGADPSINPEFVSQLQTLCPPSSDDTGRVALDTDSVDSFDVSFFENLRNGRGILESDQMLWTDASTRSI... | 14 |
E9FUJ0 | 3.4.19.12 | ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 163; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MADAGNWCLIESDPGVFSELIRDFEVQGVQVEELWSLDPEQFDNLKPIHGLIFLFKWVPNEEVVGTVVQDSRLDKIFFAKQVINNACATQAIISILLNCKHPDLHLGPTLGEFKEFTQAFDANMKGLALSNSDTIRSVHNSFARQTLFEFDSKASSKDDDTFHFVGYVPVDGRLYELDGLKEGPIDLGAVPAETDWIDVVRPIIEKRIQRYSEGEIHFNLMAIVPDRKLAWQKEIERLQSQPVVSTDMQTEIQRLLMLCEEEESKRKRQKIENVRRKHNYLPLIVQLLRMLGEKGQLLPLYEKAKQRAVAKTTTQKKS | 175 |
Q9F7B2 | 3.1.3.48 | ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 15; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P11064" | MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLILTMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP | 149 |
A7F0W2 | 2.7.11.1 | ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASKTPSSSSSRRPRNVGVGSFTINEEIGKGSFATVYRGTHVPSGSLVAIKSVNLGRLNKKLKDNLYVEIEILKSLHHPHIVALMDCRESTSHIHLMMEYCELGDLSYFIKKRDKLADNPSLFDMIRKYPMPVDGGLNQVVVRHFFKQLSSAMEFLRDRDFVHRDVKPQNLLLIPSPDWMAKSKNGPEAMKASKESIVPMVGINSLPMLKLADFGFARSLPSTSLAETLCGSPLYMAPEILRYEKYDARADLWSIGTVLYEMMTGKPPFRAANHVELLRKIEQNEDEIRFPSKTVFSRDLKDIARRFLKKRPEDRITFPE... | 99 |
A0A0Q3IY09 | 3.1.1.11 | ACT_SITE 275; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAMPWARLLACVVAVLLLLGANVVESGSRHQGRHHGRSSKSPLRRPGKKQAASPGPAKKRNETREAEAIELGFTSWVQYMGGPEHSAFLRALRLNVDVPARGASFLSPVRTLVVDKSPGAGNFTSIQAAVDSLPLINLARVVIRVNPGTYTEKVNISPMRGFVTVEGAAGAEKTVVQWGDTAETAGPWGRRSPLGTFASATFAVNAQFFVAKNITFKNTAPVPRPGALGKQGVALRISADNAAFVGCNFLGAQDTLYDHLGRHYYRDCYIEGSVDFIFGNALSLYEGCHVHAISPRYGALTAQGRTSLLDDTGFSFLNCR... | 125 |
A8BFD3 | 4.1.1.17 | ACT_SITE 397; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MSVLTRASLVEYNLLPIGKGADISKVIVDAYAKSGREAVCVLNVSEIERHYNIWKTHLPEVQVRYAVKCNMHPLLLRSLHLLGAGFDCASPAEVRAALSAGCPPSKIIYANPQKPKRSIEEAFRLNCNTFTFDSEHELLSMLESTPPGKVGRFVLRLLPPDESSSICRFGVKFGASPSECYRLIRLCKHLGANLVGFSFHVGSGCGSVDSFRLAVQYMGEAAKFAKEQGFTLTVLNIGGGYMSKGAERHYDEPNRHAHITPPSFEEIASALREEINRIKVYFTNKSEDLEIMAEPGRFFAGDIMTLGTRIYGRRIIFDKI... | 195 |
A0A9J7N454 | 3.1.1.4 | ACT_SITE 81; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 131; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MASVRTLAIATVVCLGVVIVSSEDTERHERNRSRRNIFQTMMMLSCITEKSSFDYSDYGCYCGPGGQGKPVDILDQCCKVHDECYGTAEKNCFPLFEYIGVYEYECKDRKISCAIEDKTKLSCREFLCECDRKVNLCLTKNEKEYNSAYFNMDQAKCK | 130 |
G1KG45 | 3.1.3.48 | ACT_SITE 836; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1" | MNNRLRALGGRINNIRASELPKERIRSDIVCNVHFLDGSLQSFKVNKQDTGQVLLDLTFNHMGVTEKEYFGLQHCEESAVSPRWLESDKPIRKQLKGGSSCSLYFRVRFFMPDPNTLQQEKIRHLFFLQLKADILEGRLLCPVNSAVVLASYAVQSQLGDYSASTHLPGYLSDYCFIPEQNKDFLTKVESLHEQHSGLKQSEAESCYINIARTLEFYGVELHSGRDLHNLDLMIGIASGGIAIYRKLICTSFYPWVNIIKISFKRKKFFFQQRQKPSESREHIVAFNMLNYRACKNLWKSCVELHTFFQAKKMLPHEKKL... | 149 |
E9H575 | 3.1.1.5 | ACT_SITE 788; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MLRVEVKGLVRSGVNKPHLARRPQPRRDRMPQSQLKNVEPAVEYLQEDISESIDQRLPQEEVYMLQNMRMFGSFPKPVLLELIKHIEPVHLQCNQNLFKIGHKDTNIYIVQSGRLRVYSTEADGSTINLKEVKRGEVFYSLLSFTDNLTGQPSAFKTVAAQAMEDSLVLQLPVSAFQKEVFDKQPDALIKTIQITMVRLQRVTFLALHQHLGLSAELVKSFPAKHHGERDSSPNPHRMREHAFVQKPINVNDPMDCATPPTTPLSKKKEQVKDEKDYQLLLQDGIDGFVKLLGLEDQSLLDGHIEVKKVISGTNIMKEDA... | 131 |
A0A251UN78 | 3.1.1.11 | ACT_SITE 446; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSQTCLQKVNKNAIFQNTGCAVQILSLTMMNYGRLEPKSQSEPEPLEEAANKPPTKSKSKLKLLLIIGIILIVASAVSVALAVTLRPKSSGGSGSMIRPKPTKAISRVCSRTLYHDLCVNSFLDFPGSLSATDKDLVPISVNMSLRHVGKALYTSTDFNNMEMSTRVRSAYNDCLELMEESVDQLQQSLSTVGGQRVGNSEDVITWLSASLTNQDTCTEGLSESEEGEVKKLMQEKLKDLSELVSNSLAIYSSAGDLDGVPVENRRRRLMGEFPEWMSKKERRLMQMPAAVIQADIVVSKDGNGTCRTIKEAIKKAPEK... | 125 |
C5YB26 | 1.11.1.7 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARSGNNVVVHVLVAMVVLWDGAAAGAAALPLPDLETTTTMNDTVTGSLSADFHLESCPDLHSMVRSAVQAARNQDVQITAGLLRIFFHDCFPQGCDASLLLDKTHPGSEQHVHPQNAGLNHKALQLIESIRDMVHRRCGERSVSCADILAVATSHAVNLAGGPFINMQLGHRDSVDPAQPWQVQTLPAPTADVTTLFNSFAGKGFVNAIDVVALSGAHTVGKARCSSFSDRTNNPNDDGFARELAAFCAGDGNRQHNLDVITPDSFDNRYFADLINRKGVLTSDQALTNDGRTAWIVNVFAHDQANFFQKFAQAMEKMS... | 14 |
A0A8R1Y5I1 | 2.3.1.48 | ACT_SITE 624; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MTTPGSEKGKLTDSLSAFFTPTPGGRRRKTTINTHEDSTSDEEPDGRASKLMGPLSGEVGTEGAGGSGTASKTTPSSTTSSSHHHHRRAEEQLHDALSPYFSAASGKRRSAVKGEYARMQQGGRRRVRAHAARRGRRRRRRRQSGRALEWRRGHAVARRRRRRTVARPQLAEVLAPRTPAQESIGRVDTGAGRIPNVRLDERRREGRRGRGRGGGAGAEDGRSLASAQVAEHVTLQEERRRRWGGVEDNSASAALFSSPDDRRGGKGQRKVKKEIESDESEDDAPLRKNKSSRHPPPPQASTATTSKSPLHKRIKRELRS... | 61 |
H9G588 | 3.1.4.11 | ACT_SITE 400; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 447; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MVLLSLCVCVCVCFPAQEEEEEEKKGGGKERRRERRPRLAPPSPSRQPRQGKGRQRRQKNWGFPGGAMAGGRPGVHALQLEPLRVHETLLKGSKFMKWDEEPTSRALVTLRVDPQGFFLYWTGPNMEVDILDISSIRDTRTGRYAKLPKDLKIREILGFGGPEQRPEEKLLTVIHGPDMVNVSFLNFMAVVQDDTAKLWTEELFKLATNILAQNASRNTFLQKAYTRLKIQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIKPDEFTLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLSLDQLMDFINQ... | 153 |
Q6PCG3 | 3.5.1.23 | ACT_SITE 118; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR017632-1" | MLYLLLFLGSCSFSYPYYTEDLEAPRYSINLDDPPEERWEPILNNYNHTEIRVVVKRILEIVIPEWALHILRPLAGVYLTFFAGKTYAGEIRGISKVLSMSTGEVVILNLGYEAAMFCTSIIAEDEKGNVYLGRNMDFLFSNLLAKLTMDVDFKKNGEIAYTGTTFVGYVGLVTGQSPNKFTVAANAREYDTSWWINAISALTKNSSPLSWLIRDTLNEAKSYTDAFLKLSKGPIITQVFFILAGTKAGEGAVITRNRNGVVDARFLDNKRGKWFLVQTNYDHWKMPPTFDDRRTPATAALDFTSQKNISMDSLYQVLSV... | 182 |
A0A7M7PLY5 | 3.4.19.12 | ACT_SITE 90; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MAGASAGDWCLIESDPGVFTELIRGFGVGGMQVEEIWTLDDDTALEKLKPVHGLIFLFKWQPGMDSSGTIVQDSRLDDIFFAKQVINNACATQAILSVLMNCHHGDMTLGNQLKEFKEFTSTFDPTMKGLTISNSEVIKDVHNSFARQQMFEFDSRQANKDDDVYHFVSYMPIQGRLYELDGLKDGPVDLGRADDGDWLKTVKPVIEERIRKYSANEIHFNLMALISDRRMIFNKEISRLQNQLKAVQGQEELMDTDQSGPVSADAIQSELSRYRLLQEDEDRKIKTFKVENVRRKHNYLPLIMELLKILASKGELVPLV... | 175 |
A0A9J7KJ60 | 2.7.11.25 | ACT_SITE 264; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50" | MHTEPVMAATAVADRPDHAILHKDSPIDSRNVPSHMNILTSNDVNERCKSPGVLSTSTDTENFANSKLCIEDSDETDPNRSPTPCTSQCAPGEKSSSSDNAQNVQLQYTGANRSGSWFDGLLGCLRPVWTIIGKATTNELKNGDDWEIPFENICNLQWLGSGAQGAVFLGTLNGEKVAVKKVREETETEIRHLRKLNHPNIIKFKGVCTQAPCYCIIMEYCPQGQLYENIRRGLEIPPMRMVEWAKQIASGMYYLHQHKIIHRDLKSPNVLLGVNDSLKISDFGTSKLWSDRSTQMSFAGTVAWMAPEVIRNEPVSEKVD... | 105 |
A0A3B6TFU9 | 5.1.3.3 | ACT_SITE 234; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 366; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MHDLLPVPTGTPLLGLPFFQLFLIRPHSVEEQHLAMKMARALLVAPLLASCFVALGLSGRADAAAETKTVGVYELKKGDFSIKVTNWGATLMSVILPDSRGNLGDVILGYDTVAEYVNGTAYFGGLIGRVANRIANARFTLDGKAYRLVPNDGNNTLHGGHRGFDKVVWTVKEHVAGGSSPFITLYYHSFDGEQGFPGDVDVHVKYQLSGPHELSVRMNATARGKATPVNLAHHAYWNLGGHGSGSVLGEEVRLFASRYTPVDAALIPTGHLAPVAGTPYDFRTPAAVGSRIGGLLSRGVNGYDINYVVDGGGLRPVAVV... | 211 |
Q1ZXR2 | 2.7.11.1 | ACT_SITE 634; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNIKFDMFVKDSNSIDSEELLNNYLTLNVVSQELLIQNAQKPLTPLSIEIGKTRTINKNIKSKLNFIMPSFCEYYELEGNYILYFKKLKIFEDFIIYKDQSIPISNQMEIKIGKGKVLVNGKKISIKDEEIKNNFIRDLNFLSSIKNFRNQYSHGNEIEAVESISKKENSINSLVIPTFIKFLGEIIIKTKDTIKFKNLMVLSDNFNILDDVIYQVENNELNLKNSKNSVVYKSIKKSIPIYLLSKVFEHTEFYILEKNNSILNFFCKKRIEDFNENSEDKEFNSTSENDSHESSIDLKCSSEVSQIKIERFHEYVSLFS... | 99 |
E3KKH6 | 3.4.19.12 | ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSEGWCLTESDPAIFTILLSELGVSGLQVEELWSLDNQSLEQLKPVHALIFLFKYVNSDQRDPSKQAGEQQPAPPGTWFAHQVITNACATLAILNAVMNIPSTSSKIQLGQELSQLKEFSVDLDSQMTGELLTNSERIRAVHNSFARPDPFQRDEPKQMSTEDAYHFITYLPLQGKLYELDGLNGLPVFHGKIPEGQSWTSLAREVIQNRINTYSSTEVHFNLMAVCEDRLNVLEERKASMTVDSMGYENLKMEIEAEEAKRKRWAEEVAIKRHNHIGLIHALMVGLAKHGSLAERVNLAKQKMVDRQRNRTGGHEMQLD | 175 |
P48456 | 3.1.3.16 | ACT_SITE 191; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q08209" | MSATSTRSSVTRKSSLSKSSSSDKSAKSSSNSSKSPTAASGNKQKMQYTKTRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRA... | 144 |
Q69QL4 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKLTVAIVCAMATALLAAAPSSAEAGDGELKVGYYDNKCSGVEDIVRSHVIKAIIQDRGIGGSLIRLIFHDCFVRGCDGSVLLNASDENPRPETAAPVSIGLEGFDILEEIKADLERRCPGVVSCADILIFAARDASSILSNGRVRFDVPAGRLDGVVSSAYEAQAELPDPTFTIRQLIDNFARKNFTVEELVVLSGAHSVGDGHCSSFTARLAAPPDQITPSYRNLLNYRCSRGGGADPAVVNNARDEDLATVARFMPAFVGKLRPVSALDNTYYRNNLDKVVNFNSDWQLLTQDEARGHVREYADNAALWDHDFAASL... | 14 |
M5VY20 | 2.1.1.37 | ACT_SITE 360; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MENSLVEVKYGCHSKKTPRKKKLTRARKKERTAQGFTQTYCKSLYCPERGAFFSLSRDTMGLGSGACHSCKMNEAEEAKEVFKLNSSKTGMETEIFKAGKKLGLTTYVGYQVLEIVVMKESKRPEIESTQVKVRRFFRPEDISVEKAYSSDIREVYYSEETHIMPVNNIEIKCEVRKKSDLPVCNAPVIFQHIFFCEHLYDPSKGSIKQLPAHIKLRYSTAGGDADSRKRKGKCKEGENVSEVENQRADSEQKRLATLDIFAGCGGLSDGLHQSGASITKWAIEYEEPAGDAFKLNHPESLVFIINCNVILRAVMEKCGD... | 47 |
M4DUD8 | 3.1.1.11 | ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGITDMVLFGLLLVNALLPVDTSGRMPFTYRNQLQRLCSSTEYTSLCVQTLREFRHGSPTSLDFVSFLVNKTMSGSSNLIPPLSSSMASYEVISLDDSTNTLPSPSVADSCERLMKMSTRRLQQAMEALNGSSRKRTTKHDVQTWLSAAMTFQQSCKDSVLDSGGHSSSAVSHITQKMDHLSRLVSNSLALVGTFMENPKPTVLPRWVSAGERKLLASRTSRSRPHVLVAKDGSGDYRTVMEAVNAASGNGRFIIYVKRGIYKEKVRIEKDEITLIGEGKDLTVIVGDDSAAGGTSVPDTATMTVTGDGFIARDIGIKNT... | 125 |
Q9HQT4 | 2.7.7.7 | ACT_SITE 131; /evidence="ECO:0000255|HAMAP-Rule:MF_01113" | MPAGERLPGAPAREERIVVHVDMDCFYASCERRREPALRGAPVVVGMGYEPDQTVGAVATASYEAREYGVESAQAISAALERLPRKADAPDASAAGYYRPVDMAYYESVSESVSEILHGLGDPVREVSIDEAYLDVTDRTAWDVAAGFGRHIKQRIARSVGVPASVGIAPDMSTAKLASDHEKPDGLVVVPPESVQSFLAPLDVADLHGVGPVHARALRERGIETVGELADADPYVLEAAFGERGREFHRRARGADSRPVEPRGKPKSLSRESSFDGATESFDRVREQAAALSGAVADRASRTNASYRTIGVKVVTPPYD... | 121 |
A0A804JVG0 | 2.7.1.11 | ACT_SITE 274; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MESLPNPPVPQKIGADSNGSAANSNRLFDLRSSLSSVKLPVRNGAEVKLRLGKKMGSEARLCPKIEYGDGGYVLEDVPHLTDYLPDLPTYPNPLQDNTAYSVVKQYFVNLDDTVAQKIVVHKNSPRETHFRRAGPRQKVYFESDEVHACIVTCGGLCPGLNTVIREIVCGLSDMYGVTKILGIEGGYRGFYARNTISLTTKSVNDIHKRGGTILGTSRGGHDTIKIVDSIQDRGINQVYIIGGDGTQKGASAIFEEIQRRGLKVAIAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEADSVENGIGVVKLMGRY... | 84 |
O13974 | 3.4.19.12 | ACT_SITE 143; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 146; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 247; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 323; /evidence="ECO:0000250|UniProtKB:Q96FW1" | MSSLRLRLKYENQSAVETVEANATVGSFLDLVAAKFSLPRNSIALKFGFPPQDIPLVNSDVPLSTLVSSGQQILVLKNAATSFSTNEPAKPPIPNAATKPTFPPQTEISNPPAVSHQSKNTSQDPPYVSTPIGDIALRVMPDDNSCLFRALSKPLGFSPYELREIVANQVLSNPDIYSTAILGKPSIEYASWIRKETSWGGYIELSILSSHFGVEICSVDVKTGRVDSYNPQPATGQRTYIVYSGIHYDLAALAAVLWDTDVDVVLFDASDVTITPYVQQLASLLKNMHYYTDTASFSIRCTICGTGLVGEKDATAHALA... | 175 |
A6IEX1 | 2.7.10.2 | ACT_SITE 346; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1" | MVLYCLLKNAEPLIKIYSVSHSETFSPACTEMADAETDQELNKKLNFSFCEEDTENEGQMTAQDIGRAQSQKPRRDQSEELEGPVSSPRDELYTSLNRDKQSPGPALRTSVSDFSTCPDTPVLNSKSKLPVPTNFSTPKNLLGQPEISSLEKLYVRSSKHLRLTPTSLMDEKTSLSLVNINPFTPETYRKLFLQSKGKRKTRDYLVLQETNMASRYEKEFFEVEKIGVGEFGTVYKCIKRLDGCIYAIKRSAKSFSGLSNDLDLHEVYAHAVLGHHPHVVRYYSSWVEDNHVVIQNEYCNGGSLQAAISENADSDNHFQE... | 98 |
A2DTA3 | 2.3.1.48 | ACT_SITE 281; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MNPKTIHVGDRVVVYCEQYQQLMEAIVVGAKVSTKQLYIHYVHQDKRLDRWISVKEVTDDPNVVIKTKAGKSAIRNHKILNTDELDVEKLAVEYKQFEKAHQEVTRIRNIDRITIGPYTIQAWYYSPYPNPFGKMEHLYICDHCFQYFASAEELAKHLQVTGEKCPPGNEIYRQGNLSIFEMKGMVNKVPCQCLCLLSKLFLDHKTLFYDVEGFNFYVVCECDDNGAHIAAYFSKEVNSSAYNVLSCITTLPPYQKKGYGNLCISLSYELARRSRMSGGPERPLSDLGKLAFASYWKDTLLEMFSTRLSEMTSIDNIVIL... | 61 |
Q9RTM3 | 3.4.21.89 | ACT_SITE 38; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 103; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKRPAGVRRFWREWAGPVCWALLVTQFGASAVRVDGASMLPALRHGEWLALPKAEGWVHRLGLGEYQRGDVVVFKPPRSAAYEWTNVYRGVNLPWAYRPYLVKRVVGLPGDTVQVRAGTLYVNGQPVPEPRTLNYWAAFCHDTGSDLANTPPLKVPAAHYFVMGDNRSPGGSLDSRVFGPVPAWDVDSRAVASLWPLARQEEARPACDEQPQPEKRVQLSGPVQWNPRWGFGGR | 178 |
F7C211 | 2.7.10.1 | ACT_SITE 613; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MQPLASVLGTLLAAAGFLVIHAFTSEEVEQEPCQAPGPEELEQHLTLALGQALRLCCGRANRGGHWYKEGTRLAPSGRVRAWRGRLEIATLVYEDAGLYLCVSRGSGHVLHNLTISVIDSLASGDDDEDSDSSPKDLPKGHIYPQQGPYWTHPHRMEKKLHAVPAGNTVKFRCPAAGNPMPTIRWLKNGEDFHGEHRIGGIRLRHQHWSLVMESVVPSDRGTYTCVIENALGSLRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIEVNGSSFGADGFPFVQVLKTADINSSEVEVLY... | 97 |
Q2QZK1 | 3.1.1.11 | ACT_SITE 254; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDRPNLAVAVVGLLAVVAATLPAPSWQFFDLFLPAGPSHRSSGGGFGKWVLMNHEEYVEKKSLYAMKAAGDIGGKTIDASLSAAEEAKVTWVVDPKGTPGDTTFTTIAAALEKVPEGNTKRVILDLKPGAEFREKLLLNITKPYITFKSDPANPAVIAWNDMAATRGKDGKPVGTVGSTTVAVESDYFMAYGVVFKNDAPLAKPGAEGGQAVALRLFGTKAAIYNCTIDGGQDTLYDHKGLHYIKDSLIMGSVDFIFGFGRSLYEGCTIVSVTKEVSVLTAQQRTKTIEGAIESGFSFKNCSIKGQGQIYLGRAWGDSSR... | 125 |
P44311 | 1.1.1.49 | ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00966" | MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMREALIHNEETTPETLDAFCSHLYYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQTLDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQNHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPANSRTETYI... | 6 |
P06782 | 2.7.11.1 | ACT_SITE 177; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSNNNTNTAPANANSSHHHHHHHHHHHHHGHGGSNSTLNNPKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLK... | 99 |
D6WXD9 | 4.1.1.50 | ACT_SITE 67; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 81; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 236; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MSDSVQYFEGVEKLLEIWFTTSNSNSKTADLRKIPRAKLESLLKIVRCEIISFMKNEQVDAYVLSESSMFISKRRFILKTCGTTTPLLCLEPLLLLAEQYAGFTEVEDLFYSRKNYKRPELQVTPHKHFDQEVALLDSLFPDGVAYCMGAVNKDCWYLYTLNPFPRRTPHQPLPAVKEEPDQTLEILMTDLDPEIMSIFSKEESLNATEATKRSGIDKIIPNMIIDDFLFEPCGYSMNGVTKNGCYMTIHITPEPEFSYVSFETNVPCSSYREIISKVLDTFLPGKFTVTVFANQASPTKDTAEEFQYLSSIGEWSRRDI... | 196 |
Q8P519 | 3.2.1.28 | ACT_SITE 329; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060"; ACT_SITE 511; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060" | MPHAPARSGDAMSAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPALINADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQLQKEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDRPAADVYRDL... | 165 |
A0A059D881 | 4.1.1.50 | ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MDLEVSAIGFEGYEKRLEISFYEPGLFGDPDGRGLRSLSRAQLDEIIKPAECTIVSSLSNDHVDSYVLSESSLFVYPYKIVIKTCGTTRLLKSIPPILNLAGSLSLTVRSAKYTRGCFLCPGAQPYPHRNFSEEVYVLDRYFGNLGSGRKAYLLGGSNKTKRWHVYSASADEVESVSPVYTMEICMTGLNKESSSVFFKFQSGSAAAMTINSGIRKILPNSEICAFGFEPCGYSMNAIEGSATSTIHVTPEDGFSYASFEAVGYDPKDINYNQLIGRVLACFRPKEFSVAVHANVAAKSLEQNCSLNVKGYCSGERCLEE... | 196 |
Q7MBB9 | 5.4.99.12 | ACT_SITE 65; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MSVDAVGGAVEGAPARLALRVQYLGGHFFGWQWQPGQRTVQQCLEEATERIARHPVRYHAAGRTDTGVHASGQVVHFDTHKKLAPETWVRGLNSLLPDDIAVRAAAYVSDHWHARFTALWREYRYCIHNSTVPDLFVRAQSWYYPYCPLDSEAVAAALATLPGHHDFRAFRRAGSSRPHSLVHVYTAECTREGEQIAIRVRANSFLYGMMRLLIGALAEVGSGRWSVERFAGLWQAGNREQVKYAAPPQGLCLVGVGYPDDPFKTNGIGFARCHTGQEKPEARLGNGDLESREERPPHEMSPLH | 217 |
Q8DRQ2 | 3.1.1.29 | ACT_SITE 20; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSIDKVDDSVNYYLQEKKFEKTMQRYNG | 127 |
P9WHH9 | 1.8.1.4 | ACT_SITE 443; /note="Proton acceptor"; /evidence="ECO:0000250" | MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVA... | 36 |
A0A8J1L0B3 | 2.7.1.11 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MAQPDKRLFENLSGKGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVQAKVYFIYEGYQGMVDGGDNIEEVSWESVSSILQVGGTVIGSARCKSFRTREGRLQAANNLVQRGITNLCVIGGDGSLTGANLFREEWSGLLDELVQNGKIEAEATKQYAHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFIPEYPPEEGWEDTMCNKLSENRARKKRLNIIIVSEGAIDCHNKPITSDLVKDLVMKRLGFDTRVTILGHVQRGGTPSAFDRILASRMGVD... | 84 |
Q89X59 | 1.1.1.37 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00487" | MARDKIALIGSGQIGGTLAHLIGLKELGDVVMFDIAEGVPQGKALDIAQSSPVDGFDAHYTGANSYEALDNAKVCIVTAGVPRKPGMSRDDLLSINLKVMEQVGAGIKKYAPDAFVICITNPLDAMVWALQKASGLPHKKVVGMAGVLDSARFRYFLADEFNVSVEDVTAFVLGGHGDTMVPLVKYSTVAGIPLPDLVKMGWTSQARLDEIVDRTRNGGAEIVNLLKTGSAFYAPAASAIAMAESYLRDKKRVLPSAAYLNGEYGVKDMYVGVPVVIGSKGVERVVEIELAGKDREAFDKSVGAVQGLVDACKKIAPDLL... | 5 |
Q55DJ8 | 2.7.11.1 | ACT_SITE 1116; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MKSNYSTYLYKMSELERIVNGGDVSSIFIEQDDVLGEIKNFNYDLYTKYDSLVLKDPQTQNNSPKPPSLEIFILVNLIALCGRINDKFPNLDKFLTHYKYATNIFNLLSENIINSIEKFKETLSKDLPSFQLSVIANSSIVKKDNSIIKFLSCFGSFMKLESIEYFGSVFNSLIGEEDQFSLDLLQVLIDSSNEYKKFLQILEFNQLQKYYDDGHLCLFHSIKFDNLNEFKLLFNDSTWCQQQQQQQQINPQIFWFILCKYNSSKIAHYLLNDYQINKKSLKQKNPLEISPVTLLEIAFLCFSDKIAIVLFSQFNYHELL... | 99 |
P40081 | 3.1.3.48 | ACT_SITE 11; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 13; /note="Proton donor"; /evidence="ECO:0000250" | MTGYPDVAAFDLDYTIWPCYCDTHLHGPFKPVKSSNGEVLTIICRDGYELTIYKDIPRILGDLKDNGVKLMTASRTWAPEIAQEILKIFKVKYAGVVTPLANLFDEFQWGERSKIGHLRDGLKDLYNTSDLKSKKICLFDDESRNKEVEKYGVKFVYVRDPENGPSWKLYQDYLSGKV | 149 |
A0A1U8P061 | 1.11.1.7 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQFMLTIRASMEMKITVSFPTPNRCTLLILVLFSFAASPLHASLSINFYASSCPTAELIVSNMVRSASSSDPTIPGKLLRLLFHDCFVEGCDASVLLQGNGTERSDPANTSLGGFSVIDSAKSVLEIFCPETVSCADIVALAARDAVVTAGGPAFEIPTGRRDGRISDAANVRSNIVDTSFTMIEMIRPFNSKGLSLDDLVTLSGAHTIGVAHCNAFSDRFQMDSKGNLSLIDTSLDNTYAKELMKKCPSGSSASKTVNNDPETSFAFDNQYYINLLGHKGLFQSDSVLVEDERTSARVEAFANDQETFFQSWRDSFLKL... | 14 |
Q4WHR7 | 2.3.2.26 | ACT_SITE 1305; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTRLRGASVGSYDAGVDRSQFHRSKLPSNAPDIIVQNTIDVSDPAQVLLWYREERRRQFNLLVRKYKNQLLHGCQDPDCRTPTCASYRRRVSEGPYRRYTELSARTLACYLASLDNPESGLCRNTQRLSSELSSHDHPRSSRRSSRGALTDLTEARSPSSVSSRRTPGDLPADRALLNQDTASAKPSDNTRIGSDSYTESRQQNVSAPVDGDSATQRMKDPKSFTQNLFDTLSLRMVEWLPLRRSPDVLDSDADRLGNQYVRSPKREGCEHTDTTVGSTCAKRRANLKNKSARVAPHTPSSQDASRRVPRVESKPEHQVK... | 65 |
Q2R9B1 | 3.5.1.98 | ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MATGGNSLPSPSCADDKKRRVCYYYDPGIAHIKFSDDHVMVPARVAMAHSLVGVYGMLGDMRRLRTRPATEAEIRRFHSPEYVDLLRDLTPESYFNDAALRQKAEDDHGIGGDDDCPAFDRLWKYCRGYAGGSFAAARALVDGASDIAINWSGGMHHASACKATGFCYVNDIVLAINELLGTFRRVIYVDIDAHHGDGVQNAFLDSNRVMTLSFHRYGKITPHKDFFPGSGAINEIGDGAGEHYSVNVPLDAGVRDDVYHTLFKPIVGKAMEVFQPEAIVLQCGADSLSGDRLGGMELSVRGHAECVSFLRGFNLPLLLV... | 184 |
A0A0K9PFB4 | 3.2.1.14 | ACT_SITE 138; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MNFRSLFLIIAVTALATFNLSRISWAQTCGLQASGALCRDNLCCSEYGYCGHTSAYCCSGCQSQCSCGDGGDLGSLISESLFDEILLHRNDNSCPAKNFYTHSAFIEAANSFSDFGTKGDTTIRKREIAAFLAQTSQETIGGWKDAIDGPYSWGYCYKEEVNPEHNIYCDTSNILWPCAPHQSYHGRGPIQISHNYNYGPAGEKIGENILENPDLVASNPTISFKTALWFWMTAQSPKPSSHDVIIGAWIPSSDDIAANRLSGYGVITNIINGGLECGKGTNLDYRIGFYKRYCDIFQVSYGSNLDCKNQKPFNT | 158 |
Q59638 | 2.3.1.12 | ACT_SITE 520; /evidence="ECO:0000255" | MSELIRVPDIGNGEGEVIELLVKPGDKVEADQSLLTLESDKASMEIPSPKAGVVKSIKAKVGDTLKEGDEILELEVEGGEQPAEAKAEAAPAQPEAPKAEAPAPAPSESKPAAPAAASVQDIKVPDIGSAGKANVIEVMVKAGDTVEADQSLITLESDKASMEIPSPASGVVESVSIKVGDEVGTGDLILKLKVEGAAPAAEEQPAAAPAQAAAPAAEQKPAAAAPAPAKADTPAPVGAPSRDGAKVHAGPAVRMLAREFGVELSEVKASGPKGRILKEDVQVFVKEQLQRAKSGGAGATGGAGIPPIPEVDFSKFGEVE... | 54 |
A0A0K9NY36 | 3.1.1.11 | ACT_SITE 416; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQNSNGYGQVNGGQKKQPVTMVIVSSLVLVAMVVAVAVGVSHYQKDNNNSGEPNKEPPNTSIKAIQSICQPTDYKETCEKSITSAAGSNTTDPKKLVGISFKVAMEHIHNVLAESKTMEELQKDPRNKKALEVCQETLEYSIDDLQRSLEKVDSFDLKKINTFIEDLRVWLSASSTFQETCLDAFENTTGDAGAKMKKAMNTTAELTENALAIVDGVSSILGNLQIPGLTGGRKLLGSMSLDPQDGVPSWLTDGKRKLLVDPNIKPDITVAQDGSGDFKTINEAVQRIPLSNATQFIVYIKKGIYKERVEISKKMINVMF... | 125 |
C6TCA1 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARVSPLFHSLLLISSLVLASQIHVSSGKLVPGLSWNYYLLTCPKLERIIRKHLEDVFEKDSGVAPGILRLFFHDCFPNGCDASILLNGDGDEKQHRANFGLRQEAIDAIENLRVLIYKQCLPVVSCSDILVIAAREAVRQLGGPDFDVPLGRKDGLGPNATAPDNLPAPFFRTDDLLRGFGNRGFDATDVVALSGAHTYGRAHCPSLVNRTIETDPPIDPNFNNNLIATCPNAESPNTVNLDVRTPVKFDNMYYINLLNRQGVFTSDQDIAGSPKTKEIVNQFASDQKLFFKKFSDAFVKVSQLDVITDRIGKGEIRDK... | 14 |
Q9X7R9 | 3.4.21.92 | ACT_SITE 108; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 133; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MSPFTAGPAPARTPRAEEGDTPATRFDDRLAEQLLDQRIVLLGTQVDEVSANRVCAQLLILSAQDPRTDISLYVNSPGGSVHAGLAIYDTMRLIPNDVSTLAMGFAASMGQFLLSVGTAGKRYALPNARIMMHQPSAGIGGTTADIEIQADNLDFTKRTIERITAEHTGQSPETISRDGDRDRWFTAEEAREYGMVDQVVQSLADVRPAATRRRMGL | 179 |
Q97VX5 | 2.3.1.286 | ACT_SITE 116; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MIYEKVAEELISSSYTIAFTGAGISTASGIPDFRGPQGLWKKYSPELASIEYFEKDPKNFWGFYSLRMRGLFEAQPNKAHYSLAELEKMGIIKVIITQNIDGLHQKAGSKNVIELHGTMRRSYCVLCLRTYDSLNVLSMIEKGNLPPRCDCGGIIRPDVVLFGEPVKNIYEALSIAYESDLVISIGSSLTVYPANLIPQTVKERGGKLIILNMEETPLDSIADYVVREPVEISLPKILENVRQKILS | 58 |
A0A0D1CG83 | 1.1.1.37 | ACT_SITE 202; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MFARQALRLAVPKAAAPRFFSSSTANNRAVAVLGASGGIGQPLSLLLKQNPLVSDLRLYDVRLAPGVAADISHVNTPSTTTGYQADQLGEALKDVEVIVIPAGVPRKPGMTRDDLFNTNASIVRDLAKKAAEVAPKAHLLIISNPVNSTVPIVAEVFKKAGVYDPKKLYGVTTLDVTRASTFLSGISGKKPSETIVPVVGGHSGVTIVPLLSQANGGDAVAKGEQYEKLVHRIQFGGDEVVKAKDGAGSATLSMAYAAAVFSDSLLKALNGEKGIKECAYVESPLYKDQGATFFASPVTLGKDGVEEIHSVGKVSAEEEK... | 5 |
A0A2R6WW04 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMASKMYTRMLIVVVATLVFASLGDAYGYSGNHAGLRENYYSRNCPKAVSKISGLIKYYTKEDKSLPAALIRLHFHDCFVNGCDGSVLLDSTPTNLAEKDALPNKFSLRGFEIIDKVKEAIEEICPGVVSCSDILSLAARESISFKGGPRWRVPLGRRDSLSSIAEAANISLPIPTMNYDELVENFANVGLNERDMVILSGAHTIGEAHCAVVMPRLYNFPGSRDGVDPSLDRKYAETLKRKCPPGAELTLIPMDPSFGGQRFDGNYYRNIVSKKALFGSDNALIQDKDGRAIVSKSIISPKTFFREFGLSMEKMGRIAP... | 14 |
Q8ZNY9 | 3.1.3.16 | ACT_SITE 80; /note="Proton donor"; /evidence="ECO:0000250" | MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ | 144 |
A0A3B6GW88 | 1.11.1.7 | ACT_SITE 101; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATNKLAALVVLVAFLAGPAACEGINICLNFNGWLKPSILDPLFCPRGSGPPVPSPSGSGLSYGYYNTRCPTAEKIIKDAVKKAVDENPGIGAGLIRLFFHDCFVRGCDASVLLNTTNSQNSDTEREGLPNKDSLRGFEVIDEAKTAIEAACNNTVSCADIVAFAARDASYFLSNGSINIRMPGGRYDGRESFANETDQLPGPFSNVAQLQASFAAKGLTSDEMVTLSGAHTIGRARCMFFSSRFSEMDPAYAAKLRAECNGNGNTNMNQDDVTSNVLDKQYYQNVLDNKVLFASDAVLNSTVTRAQVTENADKAGEWER... | 14 |
P23566 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSTTARRRLMRDFKRMQQDPPAGVSASPVSDNVMLWNAVIIGPADTPFEDGTFKLVLSFDEQYPNKPPLVKFVSTMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNNASPANAEAAQLHRENKKEYVRRVRKTVEDSWES | 64 |
D8QY72 | 2.1.1.37 | ACT_SITE 1140; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MAVHRGRKKRLKNNAAAPAARNPPRSDASHHSDSSDVEIISVTAFHNTGSGCKRPRPRRAAIKNLEEKEDEEEAIEAENVIEVKPEPRLADSEATAIMRTREGGEGKKEKPQRRLLDFVVHDGQGAEQPIEILETVPLFVTATILPVTGLLEKQRGFRCESFGPLESWCISGYEDGVLVVWICTEAGDYICCKPAASYKTWYSALADKSSLCIAVFKALSKPDGGDPELPLESLVAQVARRSKKTALSQPFSREYLISIGGFVSSQLKAMDVSASDGDQVFTGLPALVALEKESASCRMEDVSLASHGRKNGTLTINEPD... | 47 |
A9T961 | 4.1.1.50 | ACT_SITE 82; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 96; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 245; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT... | MGVSFQNDTGAVAGSVASPGFEGFEKRLDIEFHIPPIFSDPAGQGLRAIPRTELDQMLRAAECTIVSHMSNAELDSYVLSESSLFVYPHRLVIKTCGTTQLLRAIPILLQVTSRLNLRVSRVKYTRGTFMFPAVQPYPHGSFTEEVRYLEEYFGSLGDGGKAFVMGSKGKFPNWHIYTAADHGATAEPTYTLEMCMTKLDRQAAGNFVKAPGLETGPEMTKVANIDNILPESRICDFAFDPCGYSMNGIEGAAHSTIHVTPEDGLSYASYEAMGYNPRRVDLPMLVERVVASFKPAVLAMSVHVSDANKATHTSGSWDES... | 196 |
Q5KKM8 | 1.1.1.8 | ACT_SITE 255; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MSAASTAPSSPEVVQQFSDLDIGSTVTTPAVTRPSSPSPPSLPPSPLSSGKHKIAVIGSGSWGTALAKIAAENAWRRKEDFHSEVRMWVREKIVNGKPLTHVINKTHLNSRYLPDVVLPRNLVAVPHLKDVVKDATLIVFVVPHQFLHTVLNELARPGVLLRGAKAVTAIKGVEVNGTDIQTFASLIEAKVGLPCSALSGANIALEVAMGQFCETTIGCPTPDQSLLWHAVFNSPSFRVNTVEDVSGVSLAGALKNVVALAAGMVDGLGLGGNTKAAIMRIGLKEMTQFCLEFFEGVRPETFSNESAGVADLTVTCFSGR... | 7 |
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