Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A1U8A7H4 | 1.11.1.7 | ACT_SITE 96; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSSHSSVSGTLSARAAAMAICSSSCFVSLLLISSLLLGSYSLVSEAQETPPLVKGLSWTFYKSSCPKLESIIRSELKKVFKKDIGQAAGLLRLHFHDCFVQGCDGSVLLDGSASGPSEKDAPPNLSLRAEAFEIINKLRTLVHEKCGRIVSCADITAIAARDAVFLSGGPDYKVPLGRRDGLGFATRNETLANLPAPSSNTSVILTSLATKNLNATDVVALSGGHTIGIGHCTSFTDRLYPSQDSTMNKFFANQLKLTCPTATTDNTTDLDIRSPNVFDNKYYVDLMNQQGLFTSDQDLYTDSRTRPIVTSFALNQTLFF... | 14 |
A9RQY2 | 2.5.1.18 | ACT_SITE 17; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MEKDDRIEMLVCLDSASPYSFFALVVLLRYQERWNLNLKLLPVLLGAVHAATGNKPPSIMVPAKGQWLVEDMQRNARFMDVPIRGVPANFGTTLNSLQCQRVLTAIAESKGYDSKELAAAFLAFFRGIFGGEPNRDLNISDSKFLLKCCMAAGFTEAESEQYISSSKDEIIKLRLKENTALAVEKGMFGAPTIYVTPREKNLQGVRQPRDLMFFGSDRFEQLAFSFGKLWEGPNPQRSRL | 77 |
T1FXY8 | 2.7.11.13 | ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MVYFNGTLIISVFEAKDLKPTNFSTRHQVVSVRGLKASLDSYVTIDVDDKVLARTKTKQKTYCPVWNEKFTAEIHNGQNLCITVFHDTNIPPDEFVANCIMTFEEFITMGEAAETWIKLEPSGQLKISADLNGTFCEGDLPKERIFKEHAGPHHKRHGAMKRRVHQVRGHKFMATFFKQPTFCSICNDFIWGLTSPQGYQCQVCTCVVHKRCHQDIITICPGMKHSKNKNNEVPGHRFKIEVPHRFKVHNYKRFTFCDHCGSLLYGLFRQGLQCDACKRNVHKRCEKNIPFDCGINTGQMGKILKELGLSGESHNVPASA... | 100 |
Q9SU29 | 2.3.2.26 | ACT_SITE 839; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00104" | MTLSRSSADDSTNNANRSYSAVAGTDNKRKRDEDSSDYVGVAESLEMLKKQEIDADHMAASAQQTLISWRSGENSRSLSSSGECSSSNRPESTRLQIFVRMMSGGKTIVIHAEKYDTVEKLHQRIEWKTKIPALEQRVIYKGKQLQRENSLTYYSIEQDASLQLVARMQSTEHPVAWQTIDDIMYTISRMYKGENLQSNINEKIVTFFAMIPVESDESIAKYLNIFSNSSVPAALVMLYASSLERNKSCAKSSVKLFLSNCVALPKNQKNYCLPIVLEFCKLLRKVCPDQKLYVTCRNTLGSMLETFDNPHGVYNDQYET... | 65 |
E0XKJ9 | 3.2.1.35 | ACT_SITE 129; /note="Proton donor"; /evidence="ECO:0000255|PIRSR:PIRSR038193-1" | MKLHQGLVCLSVLILLPTCILGDRKFEVYWNIPTFMCPDQNKTIMDLNKKHGVIQNTEDLFRGDKISLLYHPGAFPAITRNKTTNTLIYENGGVPQAGNLSLHLKLLEKDINEQITDKNFSGLAVIDFELWRPIFRQNGGSLSDYQNLSLKLEKDLHPEFNEDQLRKEAERRIEKFGRSFIKQTLIKAKKLRPKAQWGYYAFPYCFNGRRRYVDTCIPSAKIDNDRILYMFENSDVIYPAVYLQTDLAQKNQTGLVKGRVDEAVRMAKMVKKPAKPPVLVYHRYVFTDTLEYISKENTTAVFKAMKDNGADGVIIWGSSF... | 166 |
Q9Z598 | 1.11.1.6 | ACT_SITE 54; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 127; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MSQRVLTTESGAPVADNQNSASAGIGGPLLIQDQHLIEKLARFNRERIPERVVHARGSGAYGHFEVTDDVSGFTHADFLNTVGKRTEVFLRFSTVADSLGGADAVRDPRGFALKFYTEEGNYDLVGNNTPVFFIKDPIKFPDFIHSQKRDPFTGRQEPDNVFDFWAHSPEATHQITWLMGDRGIPASYRHMDGFGSHTYQWTNARGESFFVKYHFKTDQGIRCLTADEAAKLAGEDPTSHQTDLVQAIERGVYPSWTLHVQLMPVAEAANYRFNPFDVTKVWPHADYPLKRVGRLVLDRNPDNVFAEVEQAAFSPNNFVP... | 13 |
K7E629 | 3.2.2.27 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MGPFPRSLVGCGLLLRPPLPGFFPCLLIRLLGNAPQASPAKKSRPEGELGAPSSPLSPEQLDRIQKNKAAALLKLASRNIPTDFGESWKRPLSAEFGKPYFLKLMGFVAEERKHHTIYPPPHQVFTWTQLCEIRDVKVVILGQDPYHGPNQAHGLSFSVQRPVPPPPSLENIYKELSTDIDGFTHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHRERGWEQFTDAVVSWLNQNLNGLVFVLWGSYAQKKGLSIDRKRHHILQTVHPSPLSAYRGFFGCKHFSKTNELLKKSGKKPIDWKAL | 173 |
A0A6P9E9T8 | 2.3.2.26 | ACT_SITE 1496; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGNRGQKRAEMVDELPADKRACSSLDFRPSSSNSSVQTHMNSPNSAHETRDNDMETSSSASASSRSEGEPERDSAYGSCDSDDAEQRHSNLRHYRDYQRQRSSTDHGKFKRILSSLSEETGPSEQLASLTELCEVLSFCTQDSLSSMVSDSLSPLLVNLAKHESNPDIMLLAIRAITYICDVYPRSSNFLIRHDAVPALCQRLLAIEYLDVAEQCLQALEKISREQPLACLQAGAIMAVLNYIDFFSTSVQRVALSTVVNVCKKLPSECPSSFMKAIPILCNLLQYEDRQLVEYVAICLIKIVERVSQSSELLDELCKHR... | 65 |
Q9FG33 | 2.7.11.1 | ACT_SITE 455; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRFSLAWKLLFLILTCKIETQVKCLKFDFPGFNVSNELELIRDNSYIVFGAIQVTPDVTGGPGGTIANQAGRALYKKPFRLWSKHKSATFNTTFVINISNKTDPGGEGLAFVLTPEETAPQNSSGMWLGMVNERTNRNNESRIVSVEFDTRKSHSDDLDGNHVALNVNNINSVVQESLSGRGIKIDSGLDLTAHVRYDGKNLSVYVSRNLDVFEQRNLVFSRAIDLSAYLPETVYVGFTASTSNFTELNCVRSWSFEGLKIDGDGNMLWLWITIPIVFIVGIGAFLGALYLRSRSKAGETNPDIEAELDNCAANPQKFKL... | 99 |
B4FG25 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGMAATRRTRASSGNNVLLLLAIGLVFSAASTTTPAVAAAALNGSDDDIGAAARAAGLSVDFHAASCPDLDGIVRSAVEEARRWDAQVTAGLLRIFFHDCFPQGCDASILLGRNQGGSEQDAPQNTGLQQAALDLVERIRGRVHSRCGASVSCADILALATSHAVNQAGGPFIPMELGRSDSRGPAPGWAVNRLPPPTDGVSELLGNFGNRGLDGSDVVVLSGAHTVGVARCSSFQDRIDKKTGKDNFEWGLTGYCNGDKEKKHALDRTPFNFDNSYFVELQNGRGVLTSDQALYRDGRTRWLVDRCASSQDEFFKRFVE... | 14 |
A0A1Z5S4B4 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MHMAACTRTSTGSNKPPSLCLLLLVHALLLAIASSPAGGLQVGFYQQTCPQAESIVRNVTWARAAADPSLAGKLLRLYFHDCFPQGCDASVLLDGRGTEKAAPPNQSLGGLDVVDAAKAALEAACPGTVSCADVVALATRDAVSFQFRRSLWQVETGRRDNRFSDEAHATDLPSPEFVFPLLRDSFAKRGLGVRDLVALSGAHTLGHTDCQFVSPRLYTFQGNGGVDPFIDPSYARELMRQCPATPPPSSSSSSGKVALDPGSEFTFDTSYYATIKANRGALHTDSVLLHDDEAARLVDEMHDQGKFLTAFAASIQKLGA... | 14 |
Q5B681 | 3.2.1.21 | ACT_SITE 152; /evidence="ECO:0000250" | MHSNILPVLTSVATLLGLVQGQSQQPYRDWAKAYEAAETLVLPWTLEQQANISVRDGTAPGFVPFEPSDGVRSVQGSGKDYDNPAMRTSSNLDDRTLHELYLWPWIDGVANGLGSVMCVMNRVNGIIGCENDHIMNGILKNETGFRGFIVPDVTAPVDKAAGLLGGLGWNSGYSVSEIMAAVKNGSIPESVMTEHALRIVATQLNLLQPPEEYAFPVETADLNVRDPSSKDFIRRAGSESIVLLKNKNNTLPLRSPMSLGIFGKDAANLATGPTPQSDFSNFAGDTYDGHLITGGGSYSPAPYVVSPLDALTARAADGQG... | 161 |
Q8MYF1 | 2.7.11.1 | ACT_SITE 251; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTTTISSNLPSQLEISPTKLLITKQPIKLRESTESPFKSMMDTFKNTIISTSPTECEESSSSTITTPSEESLSSGEESSSISDSESKIITIATLLKPSNSVQDFTPLCNGAQETEIVKISNSINLSNFIIKHLVGKGGFGKVFQVVHVDTQKVYALKVIKKNHIIAKKSVVNTLAEKDILKKISHPFIVNLHYAFQNEKKLYLVMDFVNGGQLFYHLQKEAIFSEDQVRFYMAELILALEHLHDSNIVHRDLKPENILLDSQGHCILTDFGLAKLEVKTNNETFSFAGTLEYMAPEMIQHATCGKAVDWWSIGILMYDMM... | 99 |
Q9XI01 | 5.3.4.1 | ACT_SITE 59; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 62; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 404; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 407; /note="Nucleophile"; /evidence="ECO:0000250" | MAMRGFTLFSILVLSLCASSIRSEETETKEFVLTLDHTNFTDTINKHDFIVVEFYAPWCGHCKQLAPEYEKAASALSSNVPPVVLAKIDASEETNREFATQYEVQGFPTIKIFRNGGKAVQEYNGPREAEGIVTYLKKQSGPASAEIKSADDASEVVSDKKVVVVGIFPKLSGSEFDSFMAIAEKLRSELDFAHTSDAKLLPRGESSVTGPVVRLFKPFDEQFVDSKDFDGEALEKFVKESSIPLITVFDKDPNNHPYVIKFFESTNTKAMLFINFTGEGAESLKSKYREVATSNKGQGLSFLLGDAENSQGAFQYFGLE... | 215 |
Q9UQW9 | 4.1.1.17 | ACT_SITE 377; /note="Proton donor; shared with dimeric partner"; /evidence="ECO:0000250|UniProtKB:P11926" | MPAIMEKNMLVSESLRTTELLGHVKPIDSVVTWSSPGSSRQAIGEAFKNTIEEIERAAVRGEPADSDAFFVADLNGVYRQLLRWHAKLPRVQPFYAVKCNPDPKVLALLNKFGTGFDCASKGELEQILGLGVSPDRIVYANPCKAITYVRYAASKGINLMTFDNADELYKVKQHHPNSRLLLRISTDDSNSLCRLSLKFGASLDDTGKLLDIAKSLELNVVGVSFHVGSGSYDPSAFLDAIQRSRQVFDQGLERGFNFDLLDIGGGFMNDSFDGVADLIRSALDTYFDPSIRVISEPGRFFVSSSFTLAVNVIAKRKLDD... | 195 |
Q12454 | 3.1.3.48 | ACT_SITE 114; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MTLVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMVKFCEENNIKTIHIKCQSERKADKTKPKIKRKKKTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNSEIEVDDLDIKDKVPWITVRYIARTATESKDELRVDDANASEKVARVSSVSNSLPKLKFHSM | 149 |
G1KEZ0 | 5.1.3.3 | ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MTEVKRESFGECRDGRGTVEKFLLKSDAVKVEIISLGCIITALETKDRDGKFADIVLGFDHLEGYIQKNPYFGAVVGRVANRIAKGKFVVEGREYHLALNNGPNSLHGGIKGFDKAVWTPEVLPEGVRFFRISPDGEEGYPGELKVWVTYTLKNAELTIHYRAQSSKTTPVNLTNHSYFNLAGQGSQSIYDHEFTIDADSYLPVDETQIPTGEVASVEGTAFDLRKPVELGRHLQKFHLSGFDHNFCLKQTKKPRFCARAYHPSSGRMIEVYTTQPGIQFYTGNSLDGTLKGKGGHVYPKHSGFCLETQNWPDAVNQVHF... | 211 |
Q4FZM6 | 1.11.1.6 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MANNKEKADTQMNQWKETRGSQKPNVLTTGAGHPVGDKLNLLTVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITQYCKAKVFEKVGKRTPVAARFSTVAGEAGSPDTIRDPRGFAVKMYTEDGNWDLTGNNTPIFFIRDAILFPSFVHSQERNPQTHMKDPNMVWDFWTLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVSCKDEAVYCKFHFKTDQGIRNLTVERAEQLAASDPDYGIRDLYEAIAAGNYPSWTLYIQTMTFQQAEKFPFNPFDVTKVWPHGDYPLIPVGKMVLSQ... | 13 |
Q9JZ69 | 3.1.3.48 | ACT_SITE 10; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 16; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1" | MKKPKILFVCLGNICRSPMAEYILRRRAAEAGIPLEADSAGTSGWHDGEDMHRETAKILKKHGIDASGFTSRKIRQSDAAAFDCIIAMDGKNLSELERTFGRRPEKIFKLTDLIPESGYDHVPDPWYTGDFEETFRLADAGCRALLEKISK | 149 |
A0A0A0LRN1 | 5.1.3.3 | ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 316; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKVLLPLIFLLVVAAIGFSNGNDVGIYELRRGNVSIKLTNYGATILSVILPDKNGKLDDVVLSFPSIDDFRNDTTYFGNIVGRVANRIGGAKFGINGVFYKLIPNDGRNLLHGGKKGFGDVIWKVESYVKGNHIIFTYDSFDGEQGFPGDLQVSVTYMFLETNKLGVKMQAESLNKPTPVNLAQHSYWNLDGHSSGNILSHKIKLFASSITPVDSELIPTGKITPVARTPFDFTTPREIGSQIKSAGGYDINYVVDDTGSGHLKKVAEVTGKKSGRKMELWSNQPGVQFYTGNQLKEVKGKDGAVYKQYAGLCLETQGF... | 211 |
A0A059CVC1 | 3.1.1.11 | ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPENRHSLASHLIVVVVVLLLSSRTSLCHTKGLRPGRSARKPVPQNMTRVQYSEQQFMKWVKFVGRLKHSIFKTAKNKLSPSYTLTVDKNPAYGDFTSIQDAIDSLPFINLVRVVIKVHAGVYTEKVSIPQLKSFITIEGAGAAKTIVQWGDRADTPGPKGQHMGTYGSATFGVNSPFFIAKNITFKNTTPVPKPGAVGKQAVAFRISADTAAFWGCSFLGAQDTLYDHFGRHYYKDCYIEGSVDFIFGNGLSLFELSGARDSINVGALTAQGRSSMLEDTGFSFLKCKVTGSGALYLGRAWGPFSRVVFAYTWMDDIII... | 125 |
A0A1S3ZIN8 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSYSSPSKLLTMITVLVMLAMSMTMVQGQGTRVGFYSSTCPRVESIVQSTVKSHFQSDQTLAAGLLRLHFHDCFVQGCDGSILIDGSNTEKNAVANGGLRGFEVIDDAKKQIEAVCPGVVSCADILALAARDAVVLSNGGSWAVPTGRRDGRVSSASDVNNFPSPSDSIDVQKQKFADKGLTTQHLVTLVGGHTIGTTACFFFSDRLYNFNGTGRPDPSIDPTFLPQLKSLCPNRVGGLNRVALDNGSEKSFDNSWFSNLRSGRGILKSDQLLWTDNSTNTFVQRFLGVRGLLGLTFSVEFGKSMVKMSNIGVKTGSDGE... | 14 |
D8SII5 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLLARGLCVLTIALVVLCDEGPALNYSYYAKTCPRAESIVSSSIRTFLRRDRSEVAGLLRIIFHDCFVQGCDASVLLVGLNGKESEQQAVPNLTLRPKSLQAITDIKARLEKACPGTVSCADIIALATRDAVNLAGGPWFPLPTGRKDSKSFASVQETLNNLPPPSFNASELLESFQSKGLNATDLVALSGAHTVGKAHCPTFSGRLRPSLDPDLDINFAQKLAATCREGDDDFATSNSTDLDSSTPNRFDNAYYRNLLRKKGLLTSDQQLFVDNRTSSLVEAFACSQRSFFSQFAASFVKLSKIQVLTGSEGEVRINCS... | 14 |
A0A251THH1 | 3.1.1.11 | ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQTFLIKLSTLILLAFSISSFFKFTKHPPQLSLFHQHTPLPIHIHKHIQTQTAHTHCTGSLYYNLCTQTLTTILPDLQSKPLPEIISATINQTVNDVRSTDFNVTAIRKKLRNLSAIEIRALDDCHSLFVETVTALTSAVSELKRNTSYREHSDLETLLSAAMTNQATCLDGFAFSKSRNKVRRYFSKSLRNISRQVSNSLALLKKVNRRTSKGKTEAFSEYGEMSGGYPRWMSNHDRKLLQLPVNNTVYDLVVAKDGTGNFTTIGDALNAAPNMSTTRFVIYIKAGAYYEYLEVASPKTMIMLVGEGIGKTLIKGNRSV... | 125 |
Q7V9T7 | 1.3.3.3 | ACT_SITE 113; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MSLSQPSTQSRVKVKSFLTGLQDDICKGLENIDGEGTFQEESWERPEGGGGRSRVMREGRIFEQGGVNFSEVHGEELPPSILNQRPEAKGHKWFATGTSMVLHPRNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPYLKDTRHFHKIHQEACDSINPKLHKVFKPWCDEYFFLKHRNESRGVGGIFFDYQDGSGKLYKGQNPNGLSSIASKELGEYKLSWEDLFSLAKACGNAFLPSYIPIIEKRHNQTFSDRERNFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGFKAPPESRESLLTDVF... | 27 |
Q9ZSA4 | 2.7.11.1 | ACT_SITE 156; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGCFSSKELQQSKRTILEKPLVDITKIYILGEELGRGNFGLTRKCVEKSTGKTFACKTILKTKLKDEECEEDVKREIRIMKQLSGEPNIVEFKNAYEDKDSVHIVMEYCGGGELYDKILALYDVGKSYSEKEAAGIIRSIVNVVKNCHYMGVMHRDLKPENFLLTSNDDNATVKVIDFGCSVFIEEGKVYQDLAGSDYYIAPEVLQGNYGKEADIWSAGIILYILLCGKSPFVKEPEGQMFNEIKSLEIDYSEEPWPLRDSRAIHLVKRMLDRNPKERISAAEVLGHPWMKEGEASDKPIDGVVLSRLKRFRDANKFKKV... | 99 |
P34477 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MEQSSLLLKKQLADMRRVPVDGFSAGLVDDNDIYKWEVLVIGPPDTLYEGGFFKAILDFPRDYPQKPPKMKFISEIWHPNIDKEGNVCISILHDPGDDKWGYERPEERWLPVHTVETILLSVISMLTDPNFESPANVDAAKMQRENYAEFKKKVAQCVRRSQEE | 64 |
Q9SI18 | 3.1.3.2 | ACT_SITE 305; /note="Proton donor"; /evidence="ECO:0000250" | MELSHLALVCAAIAFSSIFVVSQAGITSTHARVSEPSEEMSLETFPPPAGYNAPEQVHITQGDNAGRAMIISWVMPLNEDGSNVVTYWIASSDGSDNKNAIATTSSYRYFNYTSGYLHHATIKKLEYDPSKSRSRCSLHIRYYSDLGQTYASNQTLYNYMSNPKGQAVLFVGDLSYADDHPNHDQRKWDSYGRFVEPSAAYQPWSWAAGNYEIDYAQSISETQPFKPYKNRYHVPYKASQSTSPLWYSIKRASTYIIVLSSYSAYDKYTPQNSWLQDELKKVNRSETSWLIVLVHAPWYNSNNYHYMEGESMRVTFEPWF... | 145 |
Q746R2 | 3.5.1.88 | ACT_SITE 142; /evidence="ECO:0000256|HAMAP-Rule:MF_00163" | MPAQTILQYPHPVLKKVCHTVTAIDEAIRGLIDDLIETMREGPGSVGVAAPQIGVTLRVCVIDVSGSRHGKDNNHGLLLMVNPEIVDRSGNAVMREGCMSVPDYTGDVERSTEVRVRFLDGADGSEREITASGFEAVAIQHEMDHLDGILFLDRIVSIKTGLFRRKNYK | 183 |
Q6H7U5 | 2.7.11.1 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDDRRTILMDRYEIGRQLGQGNFAKVYYARNLTSGQAVAIKMIDKEKVTRVGLMVQIKREISIMRLVKHPNILQLFEVMASKSKIYFVLEYAKGGELFKKISKGKFSEDVARRYFHQLISGIDYCHSRGVYHRDLKPENLLLDENESLKVSDFGLSALSESKRHDGLLHTTCGTPAYVAPEVLSRRGYDGAKADIWSCGVILFVLVSGYLPFHDTNLIEMYRKIAKAEYKCPRSFSAELKDLLYKILDPDPSTRISIPKIKRSAWYRKSSDVNALKSKHETGDKVYKGEATTSDTTECSIFEGNRASSRDKVYTNGEATT... | 99 |
A0A2R6XBX2 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAFSRAWLSSVAILALLSLVAVGQAQLSTTFYSKSCPAALSIVSKQVNSIFAANPNLAGGLQRLHFHDCFVRGCDASVLLVSSSSTNQEIDAPPNKNSLRGFQQIDQVKSALEAACPGVVSCADILAIVARDATVKAGGPTWPVLLGRRDGTVSLASEALAALPSPSMNLGQLIQNFAAVGLNASDMIVLSGAHTFGRAHCGPILNRLYNFNGVHGQIDASMDSSLAANLKKQCPPNDVTTIITMDSSPNVFDRTYFKQVIARGGLFTSDAVLATDSRTLAQATRLAQPGSSFFEDFAAAMVKMSKIHVLTGSQGEIRKK... | 14 |
Q5KPY7 | 1.1.1.8 | ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MGKEKVAVVGSGNWGSAISRIAGINTKKHPDVFDDTRVSVWVYEEEFEGKKLTEIINSEHENRKYLPGVKLEDNVVAVPDLKEAVKDATALVFVTPHQFLGKVLDTLEGNVRKDAKAITLIKGVEVQGDDIHIFADVIEQRLGIPCSALSGANIANEVARDTFSETTIGYRNKEDGELWLKLFQTPKFKVQLIDDVAGVSLCGALKNIVAVAAGFIDGLGYGSNSKAAIMRIGLLEMKHFCQEFFVDVKEESFLQESAGVSDVITSCLSGRNYKVAAAFVGANKSFDQLEAEMLNGQKLQGIHTAKDVHNFLSAKNRSRA... | 7 |
A0A2I3TDT0 | 3.2.1.52 | ACT_SITE 356; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSFSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQARTPLQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGKFHAVSLLLSSKGKFSFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSIAFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSF... | 170 |
A0A0D1D1H7 | 3.5.1.98 | ACT_SITE 181; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MVVIDFDMAATGGNSNATFSDSPFFFDRSDANGAGKAIYKDAHHIQPHSNPRVSYYHPAGVGDFHYGERHPMKPARLTLTNRLVLAYGLHKHMSVFTPRQATKEELEMFHDSDYVEFLANVTPSTPPSAAFTKFNFADDCPVFDGMYDFCKSYSGASLAGARRLAAGETDIAINWSGGLHHAKKFEASGFCYVNDIVLGIMELLRYHPRVLYIDIDIHHGDGVQEAFYNSNRVMTVSFHKYGNDFFPCTGNIDEIGTGLGKHFCLNVPLQDGIDDSGYVALFKSVMEPCITTFRPSSIVLQCGADSLGLDRLGCFNLSIA... | 184 |
E9HAH7 | 5.1.3.3 | ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 326; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MNTSSTQVTQETFGTIQTSNGIQSVKKFTLTNLHGVKVQLITYGAALTNLFIRDKKGQLQDVVMGFDDIDGYLSSHNPYFGCTVGRVANRIAKGRFHLDEVEYQLAINNGDNHLHGGNMGFDKLIWQAYAHLDGRVTFTYSSPHMEEGYPGHLYTQVTYKLTDSNELIVEFNALTDRPTPVNLTNHSYFNLAGHDAGSQQLYNHRAQFFANQYTPADSKNIPTGELAKVDDTVFDLRSETRLGDVIQQVPGGGYDHNFEVSESNVKFGDTIPLAAKLWHPESGRLLEIFSDQPGFQVYTGNFFPTDGSLVGKNGTVYTRH... | 211 |
K3YHI6 | 3.2.1.1 | ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 225; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MKHSSSLGFLFLLALCSLVQAQVLFQGFNWESCKKQGSWYNSLNAQVDDIAKAGVTHVWLPPPSHSVSPQGYMPGRLYDLDASKYGTAVELKSLIAAFHRRGIQCVADIVINHRCADKKDARGVYCIFEGGTPDDRLDWGPGMICSDDTQYSDGTGHRDTGDGFAAAPDIDHLNARVQRELIDWLNWLKSDVGYDGWRLDFAKGYSPAITKMYVENSKPSFVVAEIWNSLSYNGDGKPSPNQDQCRQELVDWVQAVGEPAMAFDFTTKGLLQAAVQGELWRLRDSSGKAAGLIGWTPEKAVTFIDNHDTGSTQKMWPFPS... | 157 |
A0A7M7RDK7 | 3.4.21.92 | ACT_SITE 128; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 153; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MLKVLKQLPSVSSKLGGICHRSLHNGAKLHTPLVPIVIEQTGRGERAYDIYSRLLKERIICLMGPVNDTVSSVVIAQLLFLQSESNKKPIHMYINSPGGSVTAGLGIYDSMQYVLPPIATWCVGQACSMGSLLLTAGAPGMRHSLPNSRIMVHQPSGQAVGQATDIQIQAEEIIKLKKQINKLYVKHTGQTLDVIEQAMERDHFMSPQEALQFGLIDKVLDHPPHIGENNQQSNPAAES | 179 |
W1NLL7 | 1.11.1.6 | ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MDPYKYRPSSAYNSPFMTTNAGAPVWNDDSSLTVGSRGPILLEDYHLIEKLAHFTRERTPERIVHARGASAKGFFEVTHDISHLTCADLLRAPGVQTPLIVRFSTVIHERGSPETIRDPRGFAVKFYTREGNWDLVGNNFPVFFVRDPMKFPDVIHAFKPNPKSHIQENWRILDFLSHHPESLSTFAWFYDDVGIPTDYRHMEGFGVSAYTLLNKAGKATLAKFHWKPTCGVKSLYDDEAVIVGGTNHSHATKDLYDSIAAGNYPEWKLFIQTMNPEDQDRFDFDPVDVTKEWPEDMFPLQPVGRMVLNRNIDNFFNENE... | 13 |
P53444 | 4.1.2.13 | ACT_SITE 112; /note="Proton donor"; /evidence="ECO:0000250" | MGIFDELNLPAGVLYGDDVLKLFQYAREKQFAIPACNVTSSSTAVAALEAARDQKAPIILQTSQGGAAFFAGKGIKDSAEKREASVAGAIAAAHYIRSIAPIYGIPVVLHTDHCAKKLLPWLDGMLEEDEKFFKANGVPLFSSHMIDLSEEPVEENISTCVKYLKRMAPMKQWLEMEIGITGGEEDGVDNSEVDNASLYTQPEDIWQIEEAFRPISPYFSIAAGFGNVHGVYAPGNVKLHPELLGKHQAYVSEKLGGKDKKPVFFVFHGGSGSSKEEYREAISNGVVKVNVDTDLQWSYLVGIRDYILNNIDYLRSQVGN... | 197 |
A7F7C8 | 2.3.2.26 | ACT_SITE 1221; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTRDTPRIQEERSFSGEDDILKALWVAAPFPYLPQDAPDELKKLTIDVEDPKQLHVIHNASRRHHFQLMVESQDNPERGLCRNPLADSPVQLNKHVRVTARRNISGPKKIHVSGGETTKRSTPSTDNERFRPDPSRACSTATTSGTRSFRDNVASNEDSSGQSRKSRTTILEEYTTTDHKSFIQNVFGTVAFKMVEWLTPRNLEALANPNDTALDSDVRSSSLAQSTPSDGASTPAQKLESPSAVETELSSNKSFLPKSSEVSAEISGVPDRTVRNEESTGADATDISTRREISPNLSPTIPTDTKPGIQSSPKVLHNES... | 65 |
Q7UJI2 | 1.8.4.11 | ACT_SITE 11; /evidence="ECO:0000255|HAMAP-Rule:MF_01401" | MTERAVLAGGCFWGMQDLIRKLPGIESTRVGYTGGEVPNATYRNHGNHAEGIEILFDPEKTSYRQLLEFFFQIHDPTTPNRQGNDRGPSYRSAIYYVDEEQKQIALDTIADVNASGLWPGKVVTEVEPVSDFWEAEPEHQDYLEKVPNGYTCHFPRPNWVLPKRAATE | 39 |
P38622 | 2.7.11.1 | ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSVNPEFIADGIDFYPTTPDAAYFNAADGKNKVNRINGNSENLHHSFASGCRRSSLSVDFNVTSSDSEKSEQSCLENNSQEDEYFCDIFSTELKLDETSNKSTDYSSSNHQYPEQLELHNYKLLNKIGEGAFSRVFKAVGINTDDQAPVAIKAIIKKGISSDAILKGNDRIQGSSRKKVLNEVAIHKLVSKNNPHCTKFIAFQESANYYYLVTELVTGGEIFDRIVQLTCFSEDLARHVITQVAIAIKHMHYMGIVHRDVKPENLLFEPIPFYGLDGDMQKEDEFTLGVGGGGIGLVKLMDFGLAKKLRNNTAKTPCGTI... | 99 |
B2FND0 | 1.3.3.3 | ACT_SITE 106; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MNEFERVRAYLTDLQDRICAAIEAVDGRARFQEDLWQRAEGGGGRTRVLRDGAVFEQAGIGFSDVSGSRLPPSASANRPELAGASWRATGVSLVFHPLNPYVPTTHANVRFFQAQRDGEVVASWFGGGFDLTPFYPFDEDVQHWHQVARDLCAPFGDERYAAHKRWCDEYFFLRHRNETRGVGGLFFDDLHGDFERDFAYLRAVGDGFLDAYLPIVQQRKDAIYGEREREFQLYRRGRYVEFNLVYDRGTLFGLQSGGRSESILMSLPPRVRWEYGFTPEAGSAEARLADYLVPRDWL | 27 |
A0DCU7 | 2.7.7.7 | ACT_SITE 349; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MFKAITFIFPLPTINLTNNRIKTLTNLIQSNGGTIALNAQTLMIVGSDATLESCQKQLQKMNLDFDQYKTQLINADWVSQSLQAKKLLDLKAFQLFLDIEQKQQKVSPQTTDTRMVYVESLAKTVPIKEGVEDEMDMESGEYTILKPELRDKCEKKRLEFKRQIIKENRFMLDYEYDKDLDNYHHQEDDGYEFLLDDFQILKKEEHDNNQQNKFYGDEDCQITEVRKPQIDVLQGLDMGKAVVNVDQPLINAQLKETKQFNPGFKQKIQFWETKKEFFICDAGFAQKCFNNQIIEELEKLLKIYTNEKDKGRCIAYRKAI... | 121 |
A8WNQ8 | 2.3.2.26 | ACT_SITE 996; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSFNLVFFNGDVRRDKKQEAMLNSMVRRGKSRKMKNLAEKIEKNIQNLKIFERKFGTLNENFRLNARGNFLQSLADMEKQRTKNEEQTKAVRKIQKKWRGFRARHFLRLQFRAQFDAISDGHRGLENSNYLNFQKILQMAQLLVNFYETNKDEERLVMTLVELVKARTANRAFEQQIRDSQRFLLARCCVKFLDHADENTIFFHVFRFLEDFVTCHSHLYEAISQHGLFDAEFHLLEALIGKPEDVSIQKKPILPRHLQLLTRIFDVFVFQNPARTTPVSVHVADRLLKTICVKISDLNFANYILYYIRDHIRLSGTQHV... | 65 |
Q54W09 | 1.11.1.24 | ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTKLKVGDQAPDFTCPDKDGKLVSLKDFIKDQKPIVLYFYPKDETSICTKEACEFRDKYQKFIEAGADVIGVSRDDAESHSKFTSKYSLPFTLLTDKGGELAKLYGAEGNFLSPGRVTFIIDKNGKVALNHSALLSATSHIEESLKVIEQLK | 12 |
A0A3B3HYD4 | 1.8.1.9 | ACT_SITE 487; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAALCRGSHRWKKINSFHVLKRNLTGKHDYDLVVIGGGSGGLACSKEAAQLGQKVAVLDYVDPSAKGTKWGLGGTCVNVGCIPKKLMHQAALLGTAVKDAQRYGWQISGTVSHDWATMAEAVQNYVKSLNWGHRVQLQDKKVTYLNLKGTLVDKHTIRGLSKAGKETILTAKNIVLATGGRPKYPSNVPGAMEHGITSDDIFWLKKSPGKTLVVGASYVALECAGFLTGIGLDTTVMVRTIALRGFDQQMAGLVTDHLESYGTRFEWKSVPTRVEKLSSGALKVTWTNTQTGCEHSDTFDSLLWAVGRAPETKALGLDKL... | 37 |
E9GSD7 | 3.4.19.9 | ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 264; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 264; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MSGMCSHFGLAALVLYLLTVDVLANPRSIPVQRTTRLHPNSIRYNVNNNRPIIGILSQEPSKSMASVSPESVSYIAASYVKWLEGQGARVVPIRINQPDSYYKAIFNSINGLLIPGGGASLVTSGYGRAGSILYDLSIEANNNGDFFPVWGTCLGFELLLYLSAAKKNYLTSCESYNRASTLKFLPDASTSHLYQRAPDGVLKTLSKEKSTSNFHHWCMTRENMTMSNLDKFYRPLATSTDDSGLEFVATIEAVNYPIWGVQFHPEKNVYEWGANLTSVPHSPGAVKAGLYFADFFVSQARKSQHRFSSRREEESYLIYN... | 176 |
F0Z8K8 | 5.3.1.8 | ACT_SITE 291; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MSQIIVPLKCTSQNYEWGKFGTNSTVAQLLKGYAKECSNIIDDNKTYAELWMGSHPSAPSKVVCNNSQNQQEEINLNDYIEREQKLNHSSCIRGEIVEKRFGKDFPFLFKVLSIRTALSIQAHPDSQLAQVLFKKFPNIYKDPYHKPEIAVATTPFEALCGFRPLNEIQNFIETIPELNRSLPNLNKLDDCKEYLKSIVTILLKADSELIKNNLHHLKERLSKLDNPSDLDRLVLKLYSQYPGDVGVFFAYILNYLILKPGQAMFLAAGEPHAYISGDCIECMAPSDNVVRAGLTPKLKDVDTLAEMLTYSTGKPGLVDP... | 214 |
Q8DKB5 | 4.2.1.1 | ACT_SITE 56; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P40881" | MAVQSYAAPPTPWSRDLAEPEIAPTAYVHSFSNLIGDVRIKDYVHIAPGTSIRADEGTPFHIGSRTNIQDGVVIHGLQQGRVIGDDGQEYSVWIGDNVSITHMALIHGPAYIGDGCFIGFRSTVFNARVGAGCVVMMHVLIQDVEIPPGKYVPSGMVITTQQQADRLPNVEESDIHFAQHVVGINEALLSGYQCAENIACIAPIRNELQRQEDPPTLHVEMLTGEKNTMTTDYGTHVRQLLQQGYQISLEYADARRYRTSSWQSGPTLTGQQESQVMAAIAQLLKEHEGEYVRLIGVDPKAKRRVFEEIIQRPGQAAVAS... | 199 |
A0A078HLG2 | 3.1.1.11 | ACT_SITE 387; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGMTALLFVTTLMFVHAFSSQTQLFKPYKEENVQSLVAKACQFIDAHDSCVSNIRTHIQESGHGLTPHSVLTAAVKEAHDKAKLAMQGIPTVTTLSFRSREQIAIEDCKELVGFSVSELAWSMLEMNKLHGGGGIDGDSHDAASAGGNLKTWLSAAMSNQDTCLEGFEGTERKYEEMIKGSLRQVTQLVSNVLDMYTQLDALPFKPSRNESSVLSPEWLSETDESLMTRVSPSAMHPDAVVSVDGKGKYRTINEAINEAPNHSTKRYVIYVKKGLYRENIAMKKKKTNIMLVGDGIGQTIITGDRNFLQGLTTFRTATVA... | 125 |
P51831 | 1.1.1.100 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000250" | MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANEVVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMKEDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAGVIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDVSSVVTFLASEGARYMTGQTLHIDGGMVM | 2 |
A0A0A0LAR0 | 3.1.1.11 | ACT_SITE 206; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MADSSSNSLFIKPIYIAFAIAFTFLISSPIGSYAFTAQNVIDSPLLTKKIGTNRTIKVDINGNGEFKSIQAAVDSVPEGNSQWMIIHVRKGIYREKVHIPSSKPYIFLRGNGKGRTSIVWSQSSSDNVESATFKVEAHNFIAFGVSFKNEAPTGVAYTSQNQSVAAFVAADKIAFYHCGFYSTHNTLFDYKGRHYYDKCYIQGSIDFIFGRGKSVFHNCEMFVIDDKRLTIRGSITAQNRKSANENSGFVFIKGKVYGVGGTYLGRAKGAFSRVIFAKTYFSISVVPAGWTNWSHVGSTENLYHGEYDCYGPGSESGNRA... | 125 |
A0A1L8H2U7 | 2.7.10.2 | ACT_SITE 1015; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MALCQCAVKHSESDMEGCSFTPAGLRVFLYWSNGKEHYVTYSQGQITAEDVCIHISERLGITPLCYTLFALYDVHGKYWYPPDHVFTITKDMKLFLHFRMRYYFRNWHGMNEKEPVVFRNVPKSRDGSEERSRIEQAGAILDLASFEYLFEQGKFDFVNDVVSLKDFPMEQDIHRFKNESLGMAVLHLSHIAIKKKVSLEEVAKQISFKECIPKSFCRQIQQNNYLTKFRMKNVFKKFVRRFHLHTVSPGKLTEEDIMYKYLSTLENLATRFGCEVFKALSLELPAEGEKLPFYLNGGYMEHTETVNREPISTHQVMVSG... | 98 |
A0A9R0IBG1 | 3.2.1.23 | ACT_SITE 212; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 295; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MKKRGRFFNFFATMNSALILSLLSFLALFALVAPLPSLSSNSPPHHRHRKKLNVRKFEIADDMFWKDREPFRIIGGDLHYFRVLPEYWEDRLLRAKALGLNTIQTYVPWNLHETSPGDLSFDGIADIISFLKLCQKLDVFVMLRPGPYICAEWDLGGFPAWLLAKEPALRLRSSDPVYLQLVDKWWGILLPMVAPFLYGNGGPIIMVQIENEYGSYADDKAYLHHLVKLARRHLGDDIILYTTDGGTRVTLQKGTIPGDSVYSAVDFTTGDQPWPIFKLQKAFNAPGKSPPLSSEFYTGWLTHWGEKIAKTDADFTAAEL... | 163 |
Q17361 | 3.4.19.12 | ACT_SITE 111; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 409; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MPIVNVKWQKEKYVVEVDTSAPPMVFKAQLFALTQVVPERQKVVIMGRTLGDDDWEGITIKENMTIMMMGSVGEIPKPPTVLEKKQANRDKQAEEISALYPCGLANLGNTCYFNSCVQMLKEVNELVLKPAEEMRIREHNDRLCHNLATLFNSLRDKDRALRSKGEPIKPFAAILTLSDSFPQFEKFKQQDANECLVSIMSNVTRIYGLSGWNIESLFRIQTETTMKCLESDEVSEKKVERNNQLTCYVNQDVRFLQTGIKAGFEEEMTRNSEELNRDAKWQKNTQISRLPKYLTVNINRFFYKESTKTNAKILKSVQFP... | 175 |
Q9KNP2 | 2.7.1.11 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MIKKIGVLTSGGDAPGMNAAIRGVVRTALGAGLEVFGIYDGYQGLYEDRIKQLDRSSVSDVINRGGTFLGSARFPQFREVEVREKAIENLKKHGIEALVVIGGDGSYMGAKKLTEMGFPCIGLPGTIDNDIAGTDYTIGYLTALNTVIEAIDRLRDTSSSHQRISIVEIMGRHCGDLTLTSAIAGGCEYIITPETGLNMEQLISNIKDGIAKGKKHAIIALTELMMDANKLAKEIESATGRETRATVLGHIQRGGKPTAFDRVLASRMGNYAVHLLMEGHGGRCVGIQKEQLVHHDIIDAIENMKRPVRTDLYKVAEELF | 84 |
O84299 | 3.1.26.3 | ACT_SITE 52; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 124; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MQHTVDIQAIESKLNFTFSHPRLLITALTHPSYRNEFPSAEEDSERLEFLGDAVLGLVVTEHLFLLFPALNEGLLSTTRAALVNAEACFEYTQKLSLGEHLLIGRGEKMQSHRGKISAYANLLEAILGAVYLDGGLSPARQIIVPLLPDKESILPLMLVNPKNRLQQFTQQTLKVLPSYKALPWKSEDGSPGYHVQVFVNGDLWGEGFAGSKKEAEKLAAKQALSTHDNKN | 138 |
A0A3Q7F950 | 5.3.1.8 | ACT_SITE 311; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEMEEGFKGLLRLIGSVKNYDWGRTAKESCVGRLYRLNSRTKIDEKQPYAEFWMGTHDSGPSYIVVERGGRIQNGHANGGGIRDKCSLKDWIQKNPSVLGETVLAKWGTQLPFLFKVLSIEKALSIQAHPDKDLAILLHKEQPLVYKDDNHKPEMALALTKFEALCGFISLEELKVIVQTVPEIVEVVGNALAELVLDLSEDDEEEKGKLVLRKLFTEIMSASKDVITEVLAKLISRLNIKNKVRVLTDKEQLVLGLEKQYPSDVGVLAAFLFNYVKLNPGEALYLGANEPHAYVYGECVECMATSDNVVRAGLTPKHRD... | 214 |
Q4Q3J3 | 1.1.1.37 | ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MKPSTLSRFKVTVLGASGAIGQPLALALVQNKRVSELALYDIVQPRGVAVDLSHFPRKVKVTGYPTKWIHKALDGADLVLMSAGMPRRPGMTHDDLFNTNALTVNELSAAVARYAPKSVLAIISNPLNSMVPVAAETLQRAGVYDPRKLFGIISLNMMRARKMLGDFTGQDPEMLDVPVIGGHSGQTIVPLFSHSGVELRQEQVEYLTHRVRVGGDEVVKAKEGRGSSSLSMAFAAAEWADGVLRAMDGEKTLLQCSFVESPLFADKCRFFGSTVEVCKEGIERVLPLPPLNEYEEEQLDRCLPDLEKNIRKGLAFVAEN... | 5 |
Q9RSZ7 | 3.4.21.92 | ACT_SITE 101; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 126; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MEVMSVIPYVIEQTGRGERSYDIYSRLLKDRIIFVGTPVESQMANSIVAQLLLLDSQNPEQEIQMYINCPGGEVYAGLAIYDTMRYIKAPVSTICVGMAMSMGSVLLMAGDKGKRMALPNSRIMIHQGSAGFRGNTPDLEVQAKEVLKLRDTLVDIYHKHTDLPQEKLLRDMERDYFMSPEEALKYGLIDQVIDQTRENRGGEE | 179 |
Q746S1 | 1.11.1.24 | ACT_SITE 44; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MSLEGKKAPDFTLEGSDGKKHSLKDYAGKTVVIYFYPRDNTPGCTKEACGFRDLHQDLMARGVVLLGVSKDSLASHDKFIKAFGLPFTLLSDPDAAMMTAYGAFGEKVQYGKTTMGTIRSTVVVGPDGTVVKHWSKVAKAEAHPAQVAEFLAKQG | 12 |
A0A6I8N1F6 | 3.1.3.1 | ACT_SITE 289; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MGRQEQGQYMANLIPLCLPQRLEQCSAHSKRLINTNIIIIITMDGEPGGRGGRAGAVRGRVQQGAPAPGRTRGGEEEEEEEEEDGEEDGEEGEGSGPAVLGAPGRPPLKASGARDRTDRQLTPRPAGSQPGLVTEDSPSIRPPDPPDALSASSPGSAGLERAALALTSAALTFPTLGGGTMRALLVLLLAGTGLSSLVPEREKNPKYWREQAQQTLRRALELQSLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLDNKPGEETLLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAAVTRSQCNT... | 141 |
A0A7M7RBW2 | 3.1.3.48 | ACT_SITE 155; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR037322-1" | MGVPTENSQAKRDTTAVRDDAACSSGFDSSDDDQEPVDKSPFQIDWLDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAIAKVRQLKGSRAIQTVKQYNFVSDFRKMREEYEATRPDGDRRSISR | 149 |
Q4QB33 | 2.3.1.286 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MRPAGTLASFLERCSARKRGRGCVVLTGAGCSTESGIPDYRGPNGQYHRADFVLLTFQKFMRDDNEKRRYWARSMLGYSTMCGASCNAAHMALQAFTKSGAVAHILTQNVDGLHHLATYGGVGDAEEEHYYKYTTSDAPLKELHGNIHNVICTSCGFFMPRARLQRELRERNPGFYEQYGADVSRTRPDGDYSAPTEAVNAMHLVMCPRCNGFFKPHVVLFGENVPKPIVEATMSLVRDKASCLLCLGTSLQVYSAYRYVLQANQLGIPVAIVNAGTTRGDAIADLKLDVESVGSVLAETAHEMLGVPASMFFRRKTIQL | 58 |
E9HL84 | 1.1.1.205 | ACT_SITE 330; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 431; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MADFLITGGTTYVPEDGLVGSSLFNVGDGLTYNDFIILPGFIDFAAEEVDLTSALTKKITLKAPLVASPMDTVTESEMAISVALCGGIGIIHHNCSPEYQATEVSKVKKYRHGFIRDPVVLTTQHTVGDVLEIKRKKGFCGIPITENGRMGGKLVGIVTSRDIDFLEKSTDIPLEHVMTKAGDLVTAPSGVTLQEANAILEKSKKGKLPIVNECGELVSLIARTDLKKSREYPFASMDPGRQLLVGAAVGTREGDKQRLQLLVQAGVDVVVLDSSQGNSIFQIDMIQYIKQHYPDLQVVGGNVVTAAQAKNLIDAGVDGL... | 3 |
M9PDD4 | 2.3.2.23 | ACT_SITE 54; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | MFFNRLIITYCSPSEGGFFKAHLYFPKEYPLRPPRMKFVTEIWHPNIEKNGDVCISILHEPGDDKWGYEKASERWLPVHTVETILISVISMLADPNDESPANVDAAKEWRESYTDFKRKVARCVRKSQEECS | 64 |
Q06350 | 3.2.1.14 | ACT_SITE 223; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258" | MVGHSAQHRSKSSLVSHLLILLIFITIIIEMCLYNKIFKNQRSDDIRDNFNNGGHRVPSNVQNHGTHIRDEAFISGVYYSNWSPYKPRFHFPHDINLKQVSHIYYAFFKINSRTGGIENTDSWSDLEMNLYKSLAIKNSELIKESSNNSVQNILPLGCIGELFYLKNTCSDKKFKVIMSIGGWSDSENFKIIIKDDKLLQNFVDSSVETMFRLGFDGIDLDWEFPGNNESEPRGYLKLVRMLRLKLNSLESQIFGKRTEDHFQLSIAAPAFKDKLFYLPITEIDQYVDYWNMMTYDYYGSWSETTGYHSNLFSETELNGN... | 158 |
Q94981 | 2.3.2.31 | ACT_SITE 304; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MDSDNDNDFCDNVDSGNVSSGDDGDDDFGMEVDLPSSADRQMDQDDYQYKVLTTDEIVQHQREIIDEANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKTSRSQCEECEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHCKCGHVFCFACGENWHDPVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCW... | 67 |
F1NW21 | 2.7.10.1 | ACT_SITE 1021; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MELGPLRVLTVLLCLPPVFTGLFISMDQPTLSIQKSVLTITTNDTLNITCSGQRAVYWSWPNNQSSAEKRLAVTGCSDGPFCKTLTLLRVIGNDTGDYRCLYGDSQAATTIYVYVQDYRSPFVTSVGDQLGIVYITENKTVVVPCLGTVSNLNVSLHAKYPEKVFVPDGKSISWDNKKGFTIPSHLISYAGMVFCEAKIDNESYQSVIYIVVVVGYRIYDLTMNPHYQVELAVGEKLVLNCTVRTELNVGIDFKWDYPSIKEKRATIRDLKTTAGEIKTFVSTLTIDSVNLSDKGRYTCAASSGRMNMKNSSYFIIHESP... | 97 |
A0A2C9W907 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKGRDSMLLIILSLICSGAFTVCNAVGPRTNGGLKQNFYRTSCPQAELIVSRIMRNRAQSNSALSAKLLRMHFHDCFVRGCDASILLDAVGDTFAEKDTIPNHSLSGYDVIDEIKTELENVCPGVVSCADILALAARDAVSLQFNRPLWAVPTGRRDGNVSLASDIEANLPSPFSDFATLLQLFTNKGLDVNDLVVLSGGHTLGVAHCATFSNRLYNFNGTDGSDPSLDPQYAEFLKTQCPNPFDPATIVEIDPQSSLKFDSNFFNILLQNKGLFQSDAALLQNEQSARIVKQLKISNAFFAKFPISMNKMGAMQVLTGE... | 14 |
Q9Y0H4 | 2.3.2.26 | ACT_SITE 917; /note="Glycyl thioester intermediate"; /evidence="ECO:0000305" | MADGNGLPAGAASGGMEAGQTVNGAGSASPTPTSSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYL... | 65 |
Q8U1R6 | 5.4.99.25 | ACT_SITE 210; /note="Nucleophile"; /evidence="ECO:0000255" | MILEKAREILEEHQLCNHCLGRLFGKLGKGTNEERGRAIRLLLSMETGKEYKEPEKCELCGGVFNNLDKFAELCIKAAEGIEFETFWVGSRFPEEIEKKEEEIWRKFRVVSGEKITKEFNRELGKVIAVRYGKTPVKERPDVVFIVEPFSEKVELQVNPIYVAGRYRKLIRGIPQTPAPGFKESIATIICRAFKKHFHGKCIFKGAGREDVDVRMLGNGRPFVVEIKRPRKRKVNLKDIEEEINQSGKVEVLNLRFITPEEAERILTTRHRKVYEAIVYVKDGITKEEVEKVVKSLKNAEIKQRTPRRVLNSRADLVRVR... | 218 |
Q8W4I7 | 2.7.11.1 | ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGNCCRSPAAVAREDVKSNYSGHDHARKDAAGGKKSAPIRVLSDVPKENIEDRYLLDRELGRGEFGVTYLCIERSSRDLLACKSISKRKLRTAVDIEDVKREVAIMKHLPKSSSIVTLKEACEDDNAVHLVMELCEGGELFDRIVARGHYTERAAAGVTKTIVEVVQLCHKHGVIHRDLKPENFLFANKKENSPLKAIDFGLSIFFKPGEKFSEIVGSPYYMAPEVLKRNYGPEIDIWSAGVILYILLCGVPPFWAESEQGVAQAILRGVIDFKREPWPNISETAKNLVRQMLEPDPKRRLTAKQVLEHPWIQNAKKAPN... | 99 |
M4EHH8 | 3.5.1.2 | ACT_SITE 140; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 246; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 248; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 282; /evidence="ECO:0000256|PIRSR:PIRSR036936-1... | MEAATVAAPFSSFVTSTQNSSSSSSSPCSLLLSRKKKNLGSVNLRFKSRLSVRASSSTSDSVVTLLDYGAGNVRSIRNALRHLGFSIKDVQTPGDILNADRLIFPGVGAFAPAMDVLNKTGMGEALCTYIENDRPFLGICLGLQLLFDSSEENGPVKGLGVIPGTIGRFDSSAGGIRVPHIGWNALQVGNDSDILDDVGNRHVYFVHSYRAIPSNENKDWVSSTCHYGESFISSIRRGNVHAVQFHPEKSGGMMFYSKVGLSVLRRFLDPKSSSKQVIACLDVRTNDKGDLVVTKGDQYDVREQSNENEVRNLGKPVDLA... | 181 |
Q58EQ1 | 2.7.11.30 | ACT_SITE 365; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1" | MERYQLSVLCWWTFLISTVVDWRGVDGNNPFYRPYRIPQLCKFCDVLESNCNGKDTCESNCSITSICESPDEICVAIWRQSDDNNTIETLCHNPTVPLYGIMVENNNNTKCEMKKRISNSGPFHICSCNEVECNDMLLFKLPTNNQVVLVILVSLLPLLVLAVLVIASFYWYRLYRRRKLDEWETKKPSKHKGPKGALDCSDACAIMMDDDRSDSSSTHANNINHNMDPLPIELDLQVGKGRFAEVYKAKLRQSPSEQFETVAVKIFPYEEYASWKNEKDIFQDIDLKHENILHFLTAEERKVEKQYWLITAFHPRGNLQ... | 106 |
P0C0K3 | 2.7.11.1 | ACT_SITE 201; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01497, ECO:0000305|PubMed:17302814"; ACT_SITE 217; /evidence="ECO:0000255|HAMAP-Rule:MF_01497, ECO:0000305|PubMed:17302814" | MNNSAFTFQTLHPDTIMDALFEHGIRVDSGLTPLNSYENRVYQFQDEDRRRFVVKFYRPERWTADQILEEHQFALQLVNDEVPVAAPVAFNGQTLLNHQGFYFAVFPSVGGRQFEADNIDQMEAVGRYLGRMHQTGRKQLFIHRPTIGLNEYLIEPRKLFEDATLIPSGLKAAFLKATDELIAAVTAHWREDFTVLRLHGDCHAGNILWRDGPMFVDLDDARNGPAVQDLWMLLNGDKAEQRMQLETIIEAYEEFSEFDTAEIGLIEPLRAMRLVYYLAWLMRRWADPAFPKNFPWLTGEDYWLRQTATFIEQAKVLQEP... | 99 |
B8CEC8 | 2.3.1.48 | ACT_SITE 193; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | HGNADLAELEAEHHEITKVKNISKIIMGKYEVEAWYYSPFPPPYNQSETLYICEYCLKYMKNPQFFLKHCSQCKHHSPPGQEIYREGNLSVYELDGKDHRVYCQNLCLLAKLFLDHKTLYYDVDPFHFYVITEVDDEGAHIVGYFSKEKVSAEEYNLACILTFPQFQKCGYGKFIISLSYELSKREGKPGSPEKPLSDLGKISYRSYWTHVLLTLFAGQSGEENVQIKDISLLTGIKTEDIISTLQSLNMIRFWKGQHVVFVMQDFLDQYMKQK | 61 |
E9GJB9 | 1.1.1.8 | ACT_SITE 207; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MSLKKKICVVGSGNWGSTIAKIVGHNVVKYNEQFESQVSMWVFEEMIDGKKLTEIINETHENVKYLPNHKLPTNVIAIPDVVEAAKDADILIFVIPHQFITRICEQLVGNIKATAFGLSLIKGFLPVPGGGIELISHAINKKLNIPIAVLMGANLAPEVADEKFCETTIGAASLENGNVLRDIIQTEYFRVVVVNDVEAVEMCGALKNIVACGAGFVDGLGYGDNTKAAVIRLGLMEMIKFAELFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVKSKKSIAELEKEMLNGQQLQGPATAEEVNFMLKAKGIEDK... | 7 |
P12684 | 1.1.1.34 | ACT_SITE 710; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 844; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 920; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 1016; /note="Proton donor"; /evidence="ECO:0000255|PROSI... | MSLPLKTIVHLVKPFACTARFSARYPIHVIVVAVLLSAAAYLSVTQSYLNEWKLDSNQYSTYLSIKPDELFEKCTHYYRSPVSDTWKLLSSKEAADIYTPFHYYLSTISFQSKDNSTTLPSLDDVIYSVDHTRYLLSEEPKIPTELVSENGTKWRLRNNSNFILDLHNIYRNMVKQFSNKTSEFDQFDLFIILAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSLYTTHSLLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLIRDYLFYISSFIGCAI... | 4 |
Q6J9G0 | 2.7.10.2 | ACT_SITE 251; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMV... | 98 |
Q61RA2 | 2.7.11.1 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSADVSTKPRGSLPIPTAPGESNECYRVIRTLGEGAFGEVLLIVNNKNPDMAVAMKKMQITTQANTNNIRKEFLIQQKLSKVGHDNFIRAIGMRTENGFHFLFLEYADGGELFDKIEPDHGMPTAIAQFYFRQLIEGLKYIHDCDIVHRDIKPENLLLTTSHVLKISDFGMATLYRNEGKERLLDLSCGTIPYAAPEVCAGGKYRGPPIDVWSSGIVLIAMLTGELPWDRASDSSYAYLQWLGNNNLDENPWRKMDVRALCMLRRILTDNVHRRATIEQIKTDPWFTHNYGKLEMTYGRPLKRARYADENSPDCNISSTQ... | 99 |
Q7NI08 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MSEPLNVGDPAPEFAAEQTSGERLSLADLRGKKVVLYFYPRDNTPGCTKEACALRDRYARLQAAGVTVVGVSTDGVRSHQKFTEKFALPFALLADTEGAIAQAYGAWGEKKFMGRTSIGILRHTVVIDEAGRIAHIYRKVKPEEHADQILRDLGIAFEA | 12 |
A0A2K1KXG0 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVWNSREDEIALYGSGSLESSKTSTRRKCTVTFVVLLLAGILLAIIVPVTLHARNSSDDSVPAQQAGPPAGVTTACSATQYPDTCSNTLQNSTHSDARIFTSTTVAAASTGVDETRLSIKNSQTPENAPAVEVCLDTLTSASAELEVVLKDLNTTDKAVLNATFDDIKTRLTAAMEFHTTCLDALEEVGGPISPSVQAVSKKSTHSLHSETISSHGLNPLVWISRNLIVWISRNLIAGGVGHRRNFSAVGRHGATAPPSPNRACKRYLQRRKIMDAVKNAPIKSSSPYVIYIKSGIYNVIYIKSGIYKEQSMTTFLSPTL... | 125 |
A0A7M7LTY1 | 6.3.4.4 | ACT_SITE 40; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 68; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 170; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MNSHENSHENNSNSISTNSKKMRLEPVNKVNVVLGAQWGDEGKGKLVDLLATEADVVCRCAGGNNAGHTVVVGDKEYDFHLLPSGIIHQGCTSVIGNGLVVHIPGLFEEAEKAKSKGLEDWSERLRISDRAHLVFDLHQQVDGLQELEKSKNKSSLGTTKKGIGPTYSSKASRTGIRVCDLMGDFTVFEEKFRALVNIHQKLFPQLVVDVESELQRYQKYAKQIRPMVCDTVYLLDSLLKEPEKRILVEGANATMLDIDFGTYPYVTSSNCSIGGVCTGLGIPPRSIGEVYGVVKAYTTRVGDGAFPTEQLNELGDLLQS... | 253 |
Q980L4 | 3.4.25.1 | ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MEELPATAVGLKVNDGIVLASERRLSYGGYVLSKQAKKVYKINKFLMAGAGIYGDLQTLTRIMNVEIKYYEVSTGKPISVHAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDPIGSLIEDNYAAVGSGARIAIGVLESEYDPNMSLDVATQLITKAIKASIERDITSGDGIDLAIIDKKGNYENKFIPY | 180 |
A0A1U8B8E1 | 3.1.1.11 | ACT_SITE 362; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGRQEWLAFGLLIWGLGGQLLAWSLGVGDNLHSQCSFTRYPDLCVETMLGSGLGHGNIDIVSALVKKSMDETKFPTPDSSNPLYDTDSLKAQHSNDGHCLELMNMSLKRLNQSLLALKSSHSTTKRKNDIQTWLSAALTFQETCRDSLEGLSGSLVDQISSKMDYLSRLTSNALALANRFLSNPRNNSSRHLTSMDDFPKWVSARDRKLLQSTEIKANAVVAKDGSGNYKTISEAIEAASGGRFVIYVKSGTYKEAISTNKDGITLIGDGKYSTIIVGDDSVGGGSSLRGSATFAITGDGFMARDIGFQNTAGPQAQQAV... | 125 |
O86781 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 610; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGYVGPQSALDVVMAGLKRLEYRGYDSAGVAVLADGGLATAKRAGKLVNLDKELSEHPLPAAATGIGHTRWATHGGPTDANAHPHLDNAGRVAVVHNGIIENFAPLRAELAERGHELPSETDTEVVAHLLAEEYSACADLAEAMRLVCGRLEGAFTLVAVHADAPDVVVGARRNSPLVVGVGEGEYFLASDVAAFIAHTRDAVELGQDQVVELRRDGVRVTGFDGSPADVRSYHVDWDASAAEKCGYASFMLKEIAEQPKAVADTLLGRIDGSGTLSLDEVRIPPGVLREVDKVVVVACGTAFHAGLIAKYAIEHW... | 81 |
Q9ZVP5 | 2.7.11.25 | ACT_SITE 131; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNWTRGKTLGRGSTATVSAATCHESGETLAVKSAEFHRSEFLQREAKILSSLNSPYVIGYRGCEITREPFHNNGEATTYSLLMEYAPYGTLTDVATKNGGFIDEARVVKYTRQILLGLEYIHNSKGIAHCDIKGSNVLVGENGEAKIADFGCAKWVEPEITEPVRGTPAFMAPEAARGERQGKESDIWAVGCTVIEMVTGSQPWIGADFTDPVSVLYRVGYLGELPELPCSLTEQAKDFLGKCLKKEATERWTASQLLNHPFLVNKEPELVTGLVTNSPTSVTDQMFWRSVEEEVSEDRSSWWECHEDERIGVLSWIGHV... | 105 |
Q8TRR5 | 5.4.99.25 | ACT_SITE 78; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01081" | MSSAGKLPSEIERTLVRKSGAWTNPVYGCAPEKRPILEYIEKGVVNIDKPSGPTSHEVAAWVKAILGVNTAGHAGSLDPKVTGLLPTLLGKATKAVPALRLSGKEYVCHLKLHRAMPPKLVRKVCEEFTGPIYQMPPIKSAVKRVIRVRTIYYIEVLEIEGMSVLFRVGCEAGTYIRKLCHDIGLALGCGGHMQALRRTKAGPFTEKTLVTLHELKDAYVFWKEDGDESELRRVIRPMESAVSHLPKIILRDSAVDAVCSGASLAVPGITSLDSSLAEGELAALFTLKGELVALAKAEMNTEEILKASAGIAASPIRVLM... | 218 |
F6VN92 | 3.4.19.12 | ACT_SITE 205; /note="Nucleophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_03062"; ACT_SITE 774; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03062" | MGKKRTKGKTVPIDDSSETLEPMCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYICDNEVQYCSSNQLGQVVDYVRKQAGITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKENPPVNSPSQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGIVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVS... | 175 |
F1QVU0 | 2.7.10.1 | ACT_SITE 1068; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDYITRQTFVKLALFIFTVLRSSCALLEKAAEDPVHPNPLQSSPAEDSDVSFCDFESPCSWTLSSHSTGGDWFITSAQQHRSSRRDTQPIRDYSTGKSEGHFLLLKPSSSHLSAGRCSFHMTSPVVLSSGPFCHLQLARFQPEPHAGNISAFVKHTDSTDIKPIDLTIKEQESDSSQWEVLEAVIGQLNEPFQVTVQYSACSSHEVGFLAFDSLELKNCVMGDDYVDLGSDCEKYSSLQCHSGGCIEKQRVCDFHTDCPEGEDEGLICSTLPLGSYCSFELGSCGWLAADTQSSWRLVSGQQLIEDTHLLGTTLKNTQGH... | 97 |
F1QWE3 | 2.7.10.1 | ACT_SITE 699; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MDFILGKSFSAMFRFLTPLLLGLFSQSVSLTTAVVSMKHPLAVVHHEGSSHWARQGRSFRPTHASEPLMVPARAPSVHLSQEEIQRLRFKPTVGTIQRSEGAEVHFNCSIDINDVSQDLNILWFRNGKEIHDSMQTAISTQGTVSLQSTISIKSVQRADAGEYHCRLSVSNKFIESNSINLVVEGLPTFIIQPSDVNITRNTPFTLTCEAVGPPNPVTIKWLHKGKRFLESNQSSSIIPIEGVDAPTQFSCEAHNEKGLTASREAHINIKELPEKVSKVTVVKREANKLLLSWTPGHDGFSPLSICYIAVRELQGAGSPT... | 97 |
A0A251P4T2 | 3.1.1.11 | ACT_SITE 236; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSLLSSSSSSSSSYFFLVCTTLIVFSFWLFHAAPAVTAVRSSRVMLVHTTNNNGSTSNSTKNHHKWVGPTGHRQIAVDINGSGDFLSVQAAVNAVPANNTVNVLILISPGYYREKVVVPATKPYITFQGAGKDVTVIEWHDRASDPGPNGQQLRTYRTASVTVFANYFSARNISFKNTAPAPMPGMQGWQAVAFRISGDKAYFSGCGFYGAQDTLCDDVGRHYFKDCYIEGSIDFIFGNGRSMYKDCELHSIATKFGSIAAHYRNSADDKSGFAFVNCRVTGTGPLYVGRAMGKYSRIVYSYTYFDDVVAHGAWDDWG... | 125 |
A0A9R0JR93 | 2.1.1.37 | ACT_SITE 1207; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MGTKNNESVGDVALDDSKENEPSIKTSKGKQKKRDRNEPNGENALASRRMPKRVAACSDFKEKNLRLSDKDHLVDRKREPVVDNEIAAIGLTTGHDDPRPNRRLIDFIFHDEDGKAQPVEILEVTDLFITGVILPLEPSGDPSKDKGVRCEGFGRIETWDISGYEDGEPTIWISTEIGDYDCGKPAATYRKIYGLFYEKARACIEIYKKMSRPLGGNPDITLDELIASLVRSMSGSKNFPPGASIKEFIVSRGEFIYNQLIGLDITSNKKDQKFSDLPVLVTLRDECKKNMAYAQETVVPLSLATGGSLKIGDVEKKNEP... | 47 |
F0ZFK6 | 3.2.1.52 | ACT_SITE 305; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MNKIIILILSLLGLVCVFGQNVVPYPQQITLTNNCYVSVSPGSISISPSIQSTTFNIAVERYLNLFFPFTNTSSTSDKITLSVSINSDDETLQLGIDESYTLNIAQGSLELKSNTIYGAMRGLETFKQMIVYDVTSNTYSIQCAQIVDYPRYPWRGIMVDSARHFITKNFILHIIDALGYNKFNTMHWHLVDAQSFAVESTTYPDLTQAAFGPKAVFSHDDIQEVVAYAKTYGIRVIPEFDIPGHAAAWGVGYPELTCTCPDYAANINNIPLDISNPNTLTFLQNFFSEIAPLFPDQHFHTGGDELVTGCWNEDQNMVSW... | 170 |
O43049 | 3.1.3.16 | ACT_SITE 279; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P53041" | MAKEALELKNEANKFLKEGHIVQAIDLYTKAIELDSTNAILYSNRSLAHLKSEDYGLAINDASKAIECDPEYAKAYFRRATAHIAIFQPKEAVGDFRKALALAPSDPAARKKLRECEQLVKRIRFQEAIHNTEPPSPLANINIEDMDIPSDYDGVILEKQITKEFVEDMKERFCQGKKLPLKFAYSILRDLKELLEKTPSLIDIPVKGDETLVICGDTHGQYFDLLNIFKLHGPPSPTNKYLFNGDFVDRGSWSTEVAFTLYAYKLLYPDAVFINRGNHETDDMNKVYGFEGECRSKYNERTFNIFSETFSLLPLGSLIS... | 144 |
P43434 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000250|UniProtKB:P00593"; ACT_SITE 121; /evidence="ECO:0000250|UniProtKB:P00593" | MKLLVLAALLSVSAAAHIITPRALWQFRDMIKCAIPGSRPYSEYNNYGCFCGLGGSGTPVDELDRCCEIHDACYTQAKHLESCKSVIDNPYTNSYSFSCSGTNIICSSKNKECEEFICNCDRAAAICFSKAPYNENNKNINKKERC | 130 |
Q6C6X9 | 2.3.2.26 | ACT_SITE 1464; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MPRRDRYCADDMAVDTDDDNRDTEMGDSVILSRNRDTRELEDEIRDEDEVLEDDHDGLDDLDDEDDSRPGVSGSGGASGLLRSLAGEMGGMSWHMNFQADRVRELLDNVRQAEDATVMLILLQEISEVLLMSNQDILLYSFPVDNLCSEMAAIMTNPLFEESQDCAIMACRTLYNLWEVSPTVSSNICSAGIAKILADKLTNLTDVDFAEQAMQLLEKLSSDHPESPGHAEHLLRQGCLRAALIHLDFFATHVQRSAVNIAANCCKYLSAAMFDQIQEVMPILANTLTSSDQKVVERGSQAVARTIERLGKSCDEEDVSF... | 65 |
B8BQG6 | 1.1.1.8 | ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | SLSMKSNTQPPPYPVRVTVLGGGNFGLALATVVAKKGVPTTLLVRSEDVASHINENHRHPRYMSDICLPRMVRATCDKKSALSDATYIIHAVPVQYTREFLNSVKDDIPPNVPVLSASKGIETSSLGFMADILKECLGEDRSYAFLSGPSFAREICEGVATAVVIASEDLMLADDLADLMSGEDFAVFTSRDVIGVEVGGAVKNVIAIAAGMCEGLGLGTNAMSGLVTRGCGEMRRLGIYLGARPSTISGLSGVGDTFGTCFGPLSRNRRFGYRLGKGETAAEIRESMTEVAEGVDTSIALVKMIKERCKGYRLDLKYPI... | 7 |
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