Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
P9WIS7
2.3.1.12
ACT_SITE 523; /evidence="ECO:0000250"; ACT_SITE 527; /evidence="ECO:0000250"
MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL
54
Q92QM8
2.7.7.7
ACT_SITE 143; /evidence="ECO:0000250"
MIDSAAPPSGFCRDCLKEQAAHSRRCLACGSPRLLRHSELYRLTLAHIDCDAFYASVEKRDNPELADKPVIIGGGKRGVVSTACYIARIHGVRSAMPMFKALEACPQAVVIKPDMEKYVRVGREVRAMMQELTPLVQPLSIDEAFLDLSGTERLHHDPPARTLARFAKRVEQEIGITVSVGLSYCKFLAKVASDLQKPRGFSVIGQAEAADFLKAKPVTLIWGVGKAFAATLERDGIRAIGQLQTMEEADLMRRYGTMGRRLYRLSRGLDERSVEIDGEAKSVSSETTFNDDLARQEDLVAHLRGLSEQVAFRLRKSALAGQTVVLKLKTADFKTRTRNRRLESPTRLADRIFRTGLQLLEKEVDGTKYRLIGIGVSDLVDPDLADPPDLVDPQASRRAAAEDAINRLRDKFGKTSVETGYTFGKGRRGQ
121
A0A9R1UR99
2.4.1.18
ACT_SITE 426; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 481; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MYCSLVTLPRAADLGFLTQFYSKNSSMATRSNFYIAPSQLTKLSVGPRNQKVSSRLPHKPRLSSTPTRANHDSAVVTDELSPMTNIKAEMKTPKILELDPALGPYKDHFEYRMKRFSEQKLLIDQYEGSVEEFAKGYLKFGLNREDGSIVYREWAPAAEEAQLVGDFNDWDGSNHKMERNEFGVWSIKIPDHDGNSSIPHNSKVKFRFKHNNGVWVDRIPAWIKYATVDSTRFAAPYDGVHWDPPPSERYEFKYPRPPKPNAPRIYEAHVGMSDSEPRVNSYREFADNVLPRIQANNYNTVQLMAIMEHSYYGSFGYHVTNFFAVSSRSGTPEDLKYLIDKAHSLGLRVLMDVVHSHVSNNITDGLNGFDVGQPTQDSYFHTGPRGYHSLWDSRLFNYSNWEVLRFLLSNLRWWIEEFKFDGFRFDGITSMLYNHHGINFAFTGDYNEYFGESIDVDAVVYMMLANCLIDLLLPDAIVIAEDVSGMPGLGRPVDEGGVGFDFRLAMGIPDKWIDYLKNKNDDEWSMVDIATCLTNRRYNEKCVAYAESHDQSIVGDKTIAFLLMDNEMYSGMSCLTEASPAVDRGIALHKMIHFITMALGGEGYLNFMGNEFGHPEWIDFPRSGNNWSYEKCRRQWELVDTEHLRYKFMNAFDRAMNLLDEKFSFLSSTKQIVSSTDEDDKVIVFERGDLVFVFNFHADNTYDGYKVGCDLPGKYRVALDSDAWEFGGHGRVGHDVDHFTWPEGIPGLPETNFNNRPNSFNVLSPPRTCVVYFRVEEDIMEEAKDDVDDRDLDDVEKIQEATHEQSGNPKNTLEEEEEDERLI
73
Q6CAC0
3.2.2.27
ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072"
MKITDAFQKAPILATTTKTVANASFDQSAWLNGLKPADKELLDTEITHIHDSWLPHLHKEISKPQFLNLKKFLASREAAGVNIFPPKKDIYSWTSLTPFDKVKVIIIGQDPYHGKNQAHGLAFSVNPPTLPPPSLKNMYKCLKNDYPDFDVPAKSGLLTPWAEQGVLMLNTVLTVEEKKANAHKDKGWEAVTFTALSAAVKHNSGCVILAWGSPAAKIADKMNIDKSKHLVLKAVHPSPLSAHRGFLTCGHFKQANEWLEKRYGPEGIIKWGLEGKTVGSKGTKEATTDTVKEELAKESIKESVETVKEPTEQSSVKPTSAKSTAPPSSQEKLDQLLLSVPDVDDDELDDILPPPKKQKV
173
P73411
1.1.1.49
ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00966"
MVTLLENPFRTGLRQERTPEPLILTIFGASGDLTQRKLVPAIYQMKRERRLPPELTVVGFARRDWSHDHFREQMRKGIEEFSTGIGSEDLWNEFAQGLFYCSGNMDDPESYLKLKNFLGELDEKRNTRGNRVFYLAVSPNFFPPGIKQLGAAGMLSDPVKSRIVIEKPFGRDLSSAQSLNRVVQSVCKENQVYRIDHYLGKETVQNLMVFRFANAIFEPLWNRQFVDHVQITVAETVGVEERAGYYESAGALRDMVQNHLMQLFCLTAMDPPNAIDADSIRNEKVKVLQATRLADINNLENAGIRGQYKAGWMGGKPVPGYREEPGVDPSSTTPTFAALKLMVDNWRWQGVPFYLRTGKRMPKKVSEIAIQFRQVPLLIFQSVAHQANPNVLSLRIQPNEGISLRFEAKMPGSELRTRTVDMDFSYGSSFGVAAADAYHRLLLDCMLGDQTLFTRADEVEEAWRVVTPVLSAWDAPSDPLSMPLYEAGTWEPAEAEWLINKDGRRWRRL
6
Q19192
2.7.11.1
ACT_SITE 933; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSVYYIVLAGFLLFMALVPFNAGQQYIDDDIEVVSSCQNGYVQNAGCDQNSQVNIIITATLDGVVTALDGETGEMIWRYEDAPLLRGTLSTSDPIDIGGTSLQLMPTLDGRLFSYTHNTNLIEPLPITTDSLLESTIRLGQDAVAGGKSVTTKGFDLFTGEQKYECSMESCGPGDTETPKNPIILIRRTTNSIRAMDTLRGIERWNLSTAEIGVTLAGGITSPTLVSDVKILLQPPDGVIVAVDKYNREEWKTNVDGHIVSVWQVYGNQIGEISIFDPSNIFTTQYEVMQREQHNLQTQSSLLYMGTSNGFPFIIQSPKAKNNLKQRMNALPELSTMTELTNPRFCTANEETRSLAYNVKDETLRLVLHNAFRHSQSKAIEDKSLSGSSARRKLQIIASDTEVSAQRIGTENLRSTSVSKSGDYGYLVLESEPQRVKFKVNSPITLMQTIFSYIFNPTAVVSFLAGLIGVTVAVVYNKIAKSSPRMIEHLSSTESAETESASHRTRTTSFAPTDDEIERFVEEGSDLSTTPIGAIHRKPLMPIEKSNIETHTQPQIKPVQRLVKTDIDTDEDSFSNDEKKRLLRNRTISRSSLEGFTSRFANEFEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLREARALAMFDHPGIIRYFYAWEERPPKGFQEKEDENLLGKIKAEKLAKLHEIKKAKKHTSEGKRVRSADTASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGGSDRTTAELKEESVAFSESDEESDTTEDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETENQELEVRERNDTGDCAYLYIVMQLCAEKTLEDWIRRSKTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKTDGAPKITVRQDSDSSAKHTKNVGTRSYMSPEQLKHQQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKGDIPAILDNVPESRDFLLQLTSLEPSERPTAHEVATHKFLQ
99
Q6UD73
2.7.11.1
ACT_SITE 441; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MNLKNGLLLFILFLDCVFFKVESKCVKGCDVALASYYIIPSIQLRNISNFMQSKIVLTNSFDVIMSYNRDVVFDKSGLISYTRINVPFPCECIGGEFLGHVFEYTTKEGDDYDLIANTYYASLTTVELLKKFNSYDPNHIPVKAKINVTVICSCGNSQISKDYGLFVTYPLRSDDTLAKIATKAGLDEGLIQNFNQDANFSIGSGIVFIPGRDQNGHFFPLYSRTGIAKGSAVGIAMAGIFGLLLFVIYIYAKYFQKKEEEKTKLPQTSRAFSTQDASGSAEYETSGSSGHATGSAAGLTGIMVAKSTEFTYQELAKATNNFSLDNKIGQGGFGAVYYAELRGEKTAIKKMDVQASSEFLCELKVLTHVHHLNLVRLIGYCVEGSLFLVYEHIDNGNLGQYLHGIGTEPLPWSSRVQIALDSARGLEYIHEHTVPVYIHRDVKSANILIDKNLRGKVADFGLTKLIEVGNSTLHTRLVGTFGYMPPEYAQYGDVSPKIDVYAFGVVLYELITAKNAVLKTGESVAESKGLVQLFEEALHRMDPLEGLRKLVDPRLKENYPIDSVLKMAQLGRACTRDNPLLRPSMRSIVVALMTLSSPTEDCDDDSSYENQSLINLLSTR
99
K7DCW7
1.8.1.4
ACT_SITE 516; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MRREGRPWRSGGGAQRRWKYWRKGKYSGKMQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
36
O49298
3.1.1.11
ACT_SITE 380; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 401; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"
MDHKILLTPPKSLYTKCIITIIYVVSISHLNAHFITSCKQTPYPSVCDHHMSNSPLKTLDDQTDGFTFHDLVVSSTMDQAVQLHRLVSSLKQHHSLHKHATSALFDCLELYEDTIDQLNHSRRSYGQYSSPHDRQTSLSAAIANQDTCRNGFRDFKLTSSYSKYFPVQFHRNLTKSISNSLAVTKAAAEAEAVAEKYPSTGFTKFSKQRSSAGGGSHRRLLLFSDEKFPSWFPLSDRKLLEDSKTTAKADLVVAKDGSGHYTSIQQAVNAAAKLPRRNQRLVIYVKAGVYRENVVIKKSIKNVMVIGDGIDSTIVTGNRNVQDGTTTFRSATFAVSGNGFIAQGITFENTAGPEKHQAVALRSSSDFSVFYACSFKGYQDTLYLHSSRQFLRNCNIYGTVDFIFGDATAILQNCNIYARKPMSGQKNTITAQSRKEPDETTGFVIQSSTVATASETYLGRPWRSHSRTVFMKCNLGALVSPAGWLPWSGSFALSTLYYGEYGNTGAGASVSGRVKWPGYHVIKTVTEAEKFTVENFLDGNYWITATGVPVNDGL
125
D7TIB5
2.1.1.37
ACT_SITE 443; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAKRKGASEEAAPLQPCVVKKTKKSRAAAEASVVGAPISVNEARQKWPQRYISTFRKGSDSRTKDESIEAEDILQARRHFTEAVVDGCIYKLYDYAYVKAEDGQPDFIAKIVELFETIDREPYFTAQWFFRAEDTVIKDHAHLVDQKRVFYSDMRDDNPLDCIVSKVEIVQVAPNVDLAEKEKTIPPCDLYYDMSYSLKHLTFANLLTENSRTESDESSTISSEIGLNSTTDGINSAIGESSQVHKFQGSGMTLLDLYSGCGAMSTGLCLGASLSGLKLVTRWAVDINPHACESLKLNHPETEVRNEAAEDFLSLLKEWATLCEDFSLLGSRRPEVVNPISNRSGSDDEEDADGDDGSPVPRGEFEVKKLVAICYGDPNEINKPGLYFKVRWKGYGPSDDTWEPIEGLSKCKKSVKEFVKKGYRSSILPLPGDVDFICGGPPCQGVSGFNRFRNTEAPLDDPKNHQLVVFMDIVNYLKPKYVLMENVVDILKFAGGFLGRYAMGRLVSMNYQARLGMMAAGSYGVPQYRMRVFLWGAHPMEKLPPYPLPTHDVIGRGVVPNEFEEITVGYDKSELCKLEKALFLGDAISDLPPVTNYNGQDEMPYNKAAHTEFQRYIRLRKHDMVYCSDAEKDASEPPMLYDHRPLQLNEDDNERVCRIPKKKGANFRDLPGVMVGSDNRVEWDPSMERVLLPSGKPLVPDYAMSFVRGKSTKPFARLWWDEIVATVVTRAEPHNQAIIHPTQDRVLTIRENARFQGFPDCYKLCGPVKERYIQVGNAVAVPVALALGYSFGMASQGLCDDHPLATLPFKFPECLAKPSSTPRNPGS
47
A0A3B3HZ30
2.7.11.1
ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037568-1"
MSDSAAVSAGAERRMETRLKRLEDMLRDPRSALNLESLLDSLNALVLDLDYPALRKNKNIETFLNRYEKVVEELRDLQMKSEDFEKVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERGIMAFANSPWVVQLCCAFQDEHYLYMVMEYMPGGDLVNLTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRLGHLKLADFGTCMKMDATGMVRCDTAVGTPDYISPEVLKSQGGDGCYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPEEVEISADAKNIICAFLTDREVRLGRNGVEEIKQHPFFKNDQWTFDNIRETVAPVVPELSSDIDTSNFDEIEDDKGDVETVPTPKAFVGNQLPFVGFTYFKEDQLLNASNNSSVNNENLKGESAALQKKLHHLELQFNNDKQVKDDLEQKYRTASGRLEKITKELEEEVNCRKCLESNLRQLEREKALLQHKSLESHRKAESEADRKRCLENEVNSLRDQLDDLKRRNQNSHISNEKNIHLRRQLEEANTLLRAESEAATRLRKTQTESSKQLQQLEANVRELQDKCCLLERTKLSLEKECISLQAALETERREQSQGSETISDLMGRILALEQEARQQRQALSKAETEKRHLQDKLTDLEKEMSSKEIDLTYQLKVLQQELEQEETSHKATRALLADKSKIRVTIEGAKSESMKEMEQKLSEERLAKMRLENRILELEKHSSMMDCDYKQALQKLEELRRHKDHLTEEVKNLTLKIEQETQKRNLTQNDLKAQNQQLSILRTSEKQLKQETNHLLDIKRSLEKQNQELRKERQDTDGQMKELQDQLEAEQYFSTLYKTQVRELKEDCEERNKLYKEMQQSLHELQEERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELELKDMMARHCQELNEKDITISSLEEANRTLTSDVANLANEKEELNCKLKEALEESEKSKDWEQQISQMKQGFEKQLQSERTLKTQAVNKLAEIMNRKEIRGGGSRRNNDTDMRRKEKENRKLQLELRSEKEKLNSIMIKYQREINEMQAQLADESQMRIELQMALDSKDSDIEQLRNLLQTLSVQSMDSASVSSGPEFDADDAYTETRLEGWLSLPVRNNTKKFGWERKYVVVSSKKILFYNSEQDREQSIPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPLPLGEKSSYICHKGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVNYDVSAAKNLLLLAASQEEQQKWVSRLVKKIPKKPPPTELFARSSPRASMKVQPSQSMRRPSRQLPTAKSSPRRSNGFKLRREDSSSLC
99
A0A3N7F0J3
2.3.2.26
ACT_SITE 525; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MQEIFPFVSELGSKLSKDLTGSVAESMGPSEAVVKDFSAFLIPLHSVISEQRGFGSPISMPLKKRAFNCPLYAKEIEQLHVIFIDLLDIMEKCLEKMQDSSNLKTNGEGELNHTGWSQYLFILKELNNIAKLYKGAEEKFWTVLRLRKASLCVLIVRYAKRTDDHQWLLQHKDVTDFDSRRHLAMMMFPELKEDYEDLHEMLIDRSQLLAESFEYIVHAESDTLHVGLFMEFKNEEATGPGVLREWFFLVTQAIFDPQNALFVACPSDRRRFYPNPASKVDPMHLDYFTFSGRVIALALMHKVQVGIVFDRVFFLQLAGMHISLEDIRDADPCLYSSCKQILQMDPEFIDSDALGLTFVREVEELGSIKVVELCPGGKGIVVNSKNREKYVNLLIQHHFVTSISDPVSRFARGFSDILNPGEQKLFFRSLELEDLDWMLYGSESAICVEDWKAHTEYSSYKETDPQISWFWEIVGRMSADQRKVLLFFWTSVKYLPVEGFRGLASQLYIYKSTEPHDHLPSSHTCFYRLCFPPYPSMAIMQDRLRVITQEHVGCSFGTW
65
A0A061ERA6
3.1.1.11
ACT_SITE 428; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MFKSPSHCWGIINFYISTKMNRVAIGGVSFILVVGVCIGLIASVTHKNGSNDTTEKDVLSTTSKSVAAICSPTQFKQACVDTLGSVANNESAVPKDFIQAAIHVTLQELQAALNKSGSIFGSAVSDKTVKMAKDDCDELLQYAVDELQASFSVVGDSDLHNMEQREAEIKNWLNAVISFQESCVDQIPQPQLQQQLSNCLLNASQLTSNALAIVNSISQIMSAFNLTSSLNLNLGGGNDRQLMDEPNPDHDTTYPSWVSSKDRKLLAGGNNAQLTPNAVVAKDGSGQYKTIGDALKAYPKNLQGRYVIYVKAGIYNEYITVDKDKVNVFMYGDGPRKTMVTGRKSNRDGYTTTDTASFFAAAIGDGFIAKAMGFQNTAGPEGHQAVALRVISDRAVFYNCRMDGYQDTLYVQAHRQFYRNCVISGTVDFIFGDSNTIIQNSLLIVRKPMDNQQNIVTAHGRKFKQETTGLVIQNCRIVPDQALFPVRFKIRSYLGRPWKEHSRTVIMESTIGDFIQPAGWLEWAGNFALNTLYYAEYANRGPGAATNGRVKWKGYKVITNRNEALQFTAGPFLQGQTWLAESGVPFFLGFRPPNVKS
125
P34102
2.7.11.1
ACT_SITE 621; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSFKKQTKTPTSWFPGLKKERDLSHHKERYCTQYDVIKVNAYGKRQQRTLAVSSLGVSNLNGQSCQWFVRNSDVYSIEQDPTDSHKFSLTFLHRYHFEAETPEQAKSIISEFKRLGVGSPSGGGGGGSGVSSNGSNSTATSPNTSPIRLYVSDPSNQPTSSSPPPQPPLSESVGVHRSSPMLSSSRMISQLSQSTSENNISSPTYHPQGLSGSSTSSSSASGGGGNNNNANNSTPPNLIASSASNSSLYSSSINSSGIINSSNNNSSISFNNNNNNNNSNLTTTTTTTSTFKTPTLPISQASKFNNESESMGLSPLTPNSNSQTALMQHINAMPNTPNSNSTEGSRVWKIRAEELKKQFLLKKSSKSTQTVATTTPTPITKADIKIVLDDNKDDKNKDNNIGSGGSGNSSSKINKEKDNPYINQPSSLPSNNNSNNNNITKSNSTTTSQTNDKKDVCSSTINFDNLEVSSSSDRDLSSSKSLNKKNKQSIKKLTIDDFELLKVLGVGSFGRVYLVRRKDTGKFYAMKVLNKKDMLKKKQIAHTNTEKMVLSTMDHPFIVRLHFAFQNEDFLFMCMDYVPGGELFHHLQKAGKFPEELAKFYIAEVICSLHYLHSNNIIYRDIKPENILLDEEGHIKLTDFGLSKSGITSVVGSKNGGEGGFATTFCGTPEYLAPEIITGAGHGKAADWWSVGILLFEMLTGRSPFLASNRNDMYKSMIQGNLRMPMFLSSDAQDLLEKLLVPDPNKRLGSTQGFEEISSHPFFELIPWRMLESKMITPPFKPTIKEISLPNSNSNSNNNSQQPTNNNLTLSCDPELNAKINFQRRKSSAASVYNLDSPFKNFSWNKEEEDGIMGERESIGSISSNNSISSSPTSSSPINNNNSGGSNTAGGHRILTRKSTIGKNLRKGSV
99
H3GAP9
3.5.1.98
ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MANATKKRVSYFYHPEVGHFYYGPGHPMKPHRMKLAHHLVVNYDLYQKMDVFEPHWASAGEMKVFHAPDYIEFLQRVSPANQRDMTMDLANVRGLAVAGLTDETSDTDCPVFDGVFDFCQIYTGGTLDAVARLNFGLCDIAINWSGGLHHAKKAGGSGFCYVNDIVLGILELLKYHPRVLYIDIDAHHGDGVEEAFYVTDRVMTVSFHKYGDYFPGTGDVKDIGAKSGKYYAVNFPLHSGMDDDSYESIFKPVIDKVMETFCPSAVVLQCGADSLTGDRLGCFNVTTRGHGECVRFVKGFGLPMLVVGGGGYRIRNVSRAWAYETSILVNQEVSNNIPYNDYFEFYTPDFKLHLVPDRDLKNDNTKEYLEKHKIKIFENLRTLTGAPSVQMHQAPPARMLREEDEDAVDPDSRTENDGKHQHEAEFYHDEKDHDNSEILEDDGAELDVVPMDMDN
184
A0A1L8I0B5
3.1.1.4
ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 119; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MIFKVLALLLAVSSALASISPRNLWQFRNMIKCNIPTSDPYFDYNDYGCYCGIGGSGTPVDALDRCCQTHDKCYSDSKGHCNGILDSPYIELYDYTCSGTTVTCLSSNNACEKFICDCDRNAALCFSRAGYNSANKNLDKNRYC
130
B8BTR4
2.2.1.1
ACT_SITE 415; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MAALATAANEARGLAMDSIAAAHSGHMGLPLGCAEIGSILYGSQMQYNPKDTQWINRDRFILSAGHGSMFLYSWLNLAGFDLPMEEVKNFRQHHSMTPGHPEFPNSEHNTPGIECTTGPLGAGVSNAVGFAVSEKMAAARYNTDEHTIFDHHIYALAGDGCFQEGVSAEAAQFAAHEKLDNLIVLYDSNEVTLDKMAEYTQSEDIIKRYEAYGWETYEIDGHDLAVVEETIAAAKASNNGKPKFIKCNTIIGKGMEETEGTNAAHGEAGVPYVDKARASIGLPEEKWFVSEGTRDFFKGVQEKNTKTYDEWQATYAAWKEANPALATELENAVADVTPSAEEMLASIPEMGDAAEATRVSGFKVIQEIAKQVPQYISGSADLHGSTRNYINDGGNFGAGFDKTYAGKNLYFGIREHGMGCILNGIAYHGIFKASGSTFAVFVDYMRPTIRVASLAELNRVSYILTHDSIGVGEDGPTHQPVETVSGLRVIPNLDVYRPADAEETVAAYVSSVTRKEGPTALILSRQNLNQNTDMPAAERRAGAMKGAYVAKKESADLDLIIIATGSEVQHALEAAKDLPGARVVSMPCVEAYERQSDEYKESVLPSSCTKRIAMEAGVTAPWYKYASKVVGVDRFGFSAPGDIVMKELGMSAENLSAEIASMN
51
P78574
1.11.1.6
ACT_SITE 93; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 166; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
MATKIAGGLHRAQEVLQNTSSKSKKLVDLERDTADAHTQQPLTTDHGVRVSNTDQWLRVTNDRRTGPSLLEDQIAREKIHRFDHERIPERVVHARGTGAFGNFKLKESIEDLTYAGVLTDTSRNTPVFVRFSTVQGSRGSADTVRDVRGFAVKFYTDEGNWDIVGNNIPVFFIQDAVKFPDFVHAVKPEPHNEVPQAQTAHNNFWDFVYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFALVNKEGKRHFVKFHWIPHLGVHSLVWDEALKLGGQDPDFHRKDLMEAIDNKAYPKWDFAIQVIPEEKQDDFEFDILDATKIWPEDLVPLRVIGELELNRNVDEFFPQTEQVAFCTSHIVPGIDFTDDPLLQGRNFSYFDTQISRLGINWEELPINRPVCPVLNHNRDGQMRHRITQGTVNYWPNRFEAVPPTGTKGSGVGGGFTTYPQRVEGIKNRALSDKFREHHNQAQLFYNSMSEHEKLHMKKAFSFELDHCDDPTVYERLAGHRLAEIDLELAQKVAEMVGAPIPAKALKQNHGRRAPHLSQTEFIPKNPTIASRRIAIIIGDGYDPVAFTGLKTAIKAASALPFIIGTKRSAIYADGEDKTSSKGIIPDHHYDGQRSTMFDATFIPGGPHVATLRQNGQIKYWISETFGHLKALGATGEAVDLVKETLSGTLDVQVASSQSPEPVEWYGVVTAGGKQKPESFKESVQILKGATDFVGKFFYQISQHRNYQRELDGLASTIAF
13
Q6GNZ7
2.7.11.13
ACT_SITE 472; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MRFNGSLKLKIGEAVELQPTRWSMRHSVFKKGSYLLDPYITINVDECRIGQTSIKHRTNKPTYNEEFCVTVSEGSKVELAVFHETPIGYDDFVAHCTLSFEELIKGCATTDSFEGWVNLEPEGKLFVVITLIGTFTEGTMRDGRLIKHFTRKRQRAMRRRVHQVNGHKFMATYLKQPTYCSHCKDFIWGVFGKQGYQCQVCTCVVHKRCHQLIVTACTCKSNACKVEKQIFEQRFGINLPHKFRYHNYKVPTFCDHCGSLLWGLVKQGLQCKMCKMNVHKRCEANVAHNCGVNSVELANALAGMGLHPGNIPFKQHSVSGSVDSDSNHLEEDSISNTSSQYKFGIDDFTFLRVLGKGSFGKVMLAKSKESDNLYAVKVLKKDVILQDDDVECTMTEKRILSLACSHPFLTQLFCCFQTLDRLFFVMEFVNGGDLMFHIQKSRRFDEARACFYSAEITSALMFLHDKGVIYRDLKLDNVLLDHEGHCKLADFGMCKEGIREGCTTSTFCGTPDYIAPEILQEMQYGPLVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPGWLSQDSVEILQAFMKKKPTKRLGSLTLGGEKAILWHPFFKDINWDELNKKAIEPPFRPRIKAREDVSNFDPEFIKEDAVLTPIDESLLPMINQEEFRNFSYTAPELQNTSQDGSAQMPQ
100
A0A9R1XB28
2.3.1.286
ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSLGYAEKLSYIEDVGNVGMTEIFDPPRILQEKIERLTMMIRKSKHLVVFTGAGISTSCGIPDFRGPTGIWTLQRGGNALPEASLPFHRAMPSMTHMALVELERAGILKFVISQNIDGLHLRSGIPREKLSELHGNSFMERCSCCGMEYFRDFEVESVGLKETSRRCSNADCDVKLKDTVLDWEVDALPFEEMNPAEAHCEKADVVLCLGTSLQITPACNLPLKCLRGGGKVVIVNLQKTPKDKKASLVIHGFVDKVIGGIMELLNLRIRPFVRVDLLQTIFTQALSSDERYVNWTLRLASVHDKRAVLPFIKSVEVSFLGNHTMKEAVLDKHPFNLKRRTVLTAEPFDVILKVNLSEGCGCAYTRIKIPIDFHASADSMKRDKDHVLRKLKSKAVKGSYCGQNSVIERSVIMMGPKTEMTVRAIVTNIRWYDEKMVKTAGAGSLTTNAYAPPLKRRIQGKNENGTPRKHLKGLIRHQTVKLDME
58
E9GU99
2.7.11.23
ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
MHVSREREPRLQRYEKIEFLGEGQFATVYKAKDTQNDNKIVAVKKIKLGSREEARDGINRTALREIKLLQELKHDHIIGLLDVFGHRSNVSLVFDFMDTDLEQIIKDTSIILTPAHIKAYILMTLQGLEYLHLLFILHRDLKPNNLLVDRQGILKLGDFGLAKSFASPTRIYTHQVVTRWYRCPELLFGARMYGTGVDVWAVGCIMAELLLRLPFLPGESDLDQLTRIFTTLGTPNEENWPGLLSLPDFVQFKAFPVIPMRHIFTAAGDDLLQLLSRFLALHPLDRCTCSEALQMPYFSNKPAPAPGSSLPLPASLSQAAVDKSGTKRKVTDNGEGGSLAKRLVF
103
A0A2R6X6Z9
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATRSSSSVLVFVGLAVLLAAVADAQLSESFYARTCPGGVQAVANVVNNAVRNDRRFAAGLLRLHFHDCFVRGCDASVLLNSASRNAEKDAPPNLTLQGFAIIDQAKAALERTCPGVFSCSDILALAARDAVSFIGGPRWRVPLGRRDGSISRAAEANSQLPTTRMGFRALAQNFARKGLSESDMVILSGAHTIGLTHCRDVTPRIYNFAGSRDGADPYLNRTYVTEKRRACPNTRAAAGNFVNLDSSLGGQRFDKNYYENVLNHKAVFNSDDALIAVARGLNQVRSIVRNPQSTFFSQFGAAMEKMGRISVLTGSRGQIRRTCSRTN
14
F1QJL2
5.4.99.12
ACT_SITE 60; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1"
MQQTVARYLIFFQYTGSKYSGVMKAPAHQAVQGVGNHLENAVRKLKPVNEVCVSISSRTDTGVHALCNSAHVDIQRRADKPPLSEQSLLEALNFQLKEEPIRITRAYRVHSDFHARYQAQSRTYVYRLALGCQHHTLMPLTEKDLCWALRDTRLNIDAMREASALLLGTHDFSTFRALSSDAPFKCPVKTLDLAQLEPGESFSQRHFQRDIQFWELTFKSRSFLYRQVRRMTGVLVAIGQGRLSVSKIQDLLEARDSLAFPNNLTAPAHGLFLTNVQYRDTDLVASMSEEQ
217
A0A2I3RMA9
2.7.10.1
ACT_SITE 655; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1"
MEARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
97
D7TIY3
2.3.2.26
ACT_SITE 1129; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MDDHRKHQVSLRGASAKEITRDALLEKVSQERELRNYVRRATAAAIFIQRVWRRYNVIKMVAVQLQEEWETLVNHHAVLMTRTWISSSFLRPFLFFITYLSIRHQRIRTRDVDCIRHCFKTLLESINSTDSKMNFCSLATGTPEERRIWTYEAEKLISICLFILAECDTHPGGQDINVLSSMAMRLLVVLTDTKGWKSITDDNFQDADRAVKDLVRFMGSRKGGLYLCIRKYFNKLDAPCSSLKNSVVQADERFLITASAITLALRPFQAANLDVTEPGPFNVQYAAEQYCVYILTIPWLAQRLPAVLLPAMKHKSILSPCFQTLLILRKKILKEMSEMHPFQIPHCSKAVPQVSWALANVICLATGSENDCVDQGQFTQGLNHTSYVHVVNILAENLLDWLEDVGWIRKDNQEIQENVETCANPIDIACSPDTTYGPIKMSYMDLFRPVCQQWHLMKLLAILKNVAFICDSSLPNNLEYSGKLELLDIAYFYSYMLRIFSVLNPVVGPLPVLNMLAFTPGFLVNLWEALEGYLFPGDVKFSEDNDLCKSKISTNKNDGAYEKKQKQASRDGGNKWVTMLQKITGKSQMDVDLISGRTRTSQVKEDAFDVWDVEPLRCGPQGISKDISCLLHLFCATYSHLLLVLDDIEFYEKQVPFTLEQQRRIASMLNTLVYNGSFHGSGGQQNRPLMDAAVRCLHLLYERDCRHQFCPPGLWLSPARNNRPPIAVAARTHEVLSAKPDDALTIPSMAPVITTTHVFPFEERVQMFREFIKMDKFSRKMAGEVAGPGSRSVEVVIRRGHIVEDGFQQLNSLGSRLKSCIHVSFISECGLPEAGLDYGGLFKEFLTDIAKAAFAPEYGLFSQTSTSDRLLVPNTAARFLENGTQMIEFLGKVVGKALYEGILLDYSFSHVFIQKLLGRYSFLDELSTLDPELYRNLMYVKHYDGDVKELSLDFTVTEESLGKRHIIELKPGGKDAIVTNENKLQYVHAMADYKLNRQMLPLSNAFYRGLTDLISPSWLKLFNASEFNQLLSGGNHDIDITDLRNHTRYTGGYTEGSRTVKLFWEVITGFEPKERCMLLKFVTSCSRAPLLGFKHLQPTFTIHKVACDVPLWATIGGQDVERLPSASTCYNTLKLPTYKRPSTLRAKLLYAINSNAGFELS
65
P77972
4.2.1.11
ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 341; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"
MLSKVPATIEEIAAREILDSRGRPTIEAEVRLESGAHGIAQVPSGASTGSFEAHELRDGDPKRYDGKGVEKAVRNVTEKIAPVVEGLDAFDQMAVDQAMIDRDGTDNKKELGANAILGVSLATAKAAAAELAIPLYRYLGGPLANVLPVPMMNVINGGAHADNNVDFQEFMIMPVGAETFKEALRWGAEVFAVLGKVLKERKLLSGGVGDEGGYAPNLTSNQQALDILIEAIEQAGYKPGSQIALAMDIAASEFFKNGQYEYDGGSHSPQEFIDYQAKLVSQYPIVSIEDGLHEDDWESWKGLTTSLGTKTQLVGDDLMVTNPVRLQKSIDLGVANAILIKLNQIGTLSETLETISLATRHSYRSVISHRSGETEDTTIADLAVATRVGQIKTGSLCRSERVAKYNRLLRIEDELGDRAVYAPKIGLGPKHS
200
Q383C5
2.3.1.48
ACT_SITE 417; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MASLAAKKDGGDINGGPSEEEDQLQQLLGTSCCVNLSDSTVKRGFLLEVRYLWLPRLLSGNGTTGVAPQLYGFVRIKDADHRISGWFPIDCIDLKETGGANGATSCGSSYPTNSAAYNSMVVAKSKITHPIISPVYREVTPGMVRTRREGKQLDFFEERLLRDCRTPTTVRYFIYLCKFAFPPWYYAPYGMLNREYDPLAPLSDAEREALRFTEGSTNESIDTNPFIRDAYLCPFSLRIYSTFEQMQHETLRYRAGHLHPPGLEIYRDDTRGFSMFEVNGSRHVTYCRHLFLLGKSFLENKLAGHDVHNYYFYVVCLHHRHYPHYTDDTSAMYFVGYFTWEKQVTDNNLACIVTLPYFMGGGASSGQQNDLSDDRGPVGADTASREGDTPKLGHFGQFMIAASYELAYRRKNVGSPEKPLTDLGAAAYDRYWKRVLIKWMHTLLEGNAAAITVDDDAGDDGQSVTIVVAHENEAKMAAPGALKRPRPGTTDGSGCAEAVRGARVAEGDTLVDTTVRSIAKQVRLEEADVLRTLLQMGVLHLNAEDRSMRVVIPVSFVNREYGKMKKWAHDMTRAEFDPKLLTGRGGPAWLVNTPSPRRHNQHQS
61
Q8IJ70
2.3.2.23
ACT_SITE 87; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
MNPQTSLTRKQCDFTKLIMAGYDLELNNGSTQDFDVMFHGPNGTAYEGGIWKVHVTLPDDYPFASPSIGFMNKLLHPNVDEASGSVCLDVINQTWTPLYSLVNVFEVFLPQLLTYPNPSDPLNSDAASLLMKDKNIYEEKVKEYVKLYASKDLWEQQKKEKKPSNINGNISPVSELSYVDQDVQDIDLDNL
64
A0A0A0KVN5
3.1.1.11
ACT_SITE 166; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAAQPRVLTVAHDGCADFCTVQEAIDAVPFSNTCRTIIRVSPGIYKQPLYVPKTKNFITFAGLNPETTILTWDNTATKINHHQAARVIGTGTFGCGSTIVEGEDFLAENITFENSSPQGSGQAVAIRVTADRCAFYNCRFLGWQDTLYLHYGRQYLKDCYIEGSVDFIFGNSTALLEHCHVHCKSKGFITAQSRKSSQETTGYVFLRCVITGSGETSYVHLGRPWGPFARVVFAYTHMDVCIKPAGWDNWGKAENERTACFYEYKCFGPGSCSMKRVCWARELLDEEADEFILHRFIDPDVDRPWLCQRMALRIPFSA
125
Q4Q5C3
5.3.1.8
ACT_SITE 292; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MSELVKLEAGHQDYAWGKDAASSFVAKMKGLTNDKSGKMFAELWVGTHPNCPSKIADGNAQLLEDFLKQPENKKTYFSEAHQATIFRDTVPYLLKILSIRTALSIQAHPCKKLAEELHAARPDKYKDPNHKPELICALTSFEALCCFRPLGAIIAYLKRIPELAELVGADAVLGQYMMAPESALPAADSDEEKQSLKAMMTNVYAASDDIVAKTLRLHLQRIEETGAQCAEDELFARIYRQYPDDVGCWMVYFLNYVQMVPGEALFLSDSEPHAYISGDGVEIMACSDNVVRAGLTPKWKDVPTLISMLKYDTTGLASASHERKSNEDAAQWQVQYYRPPAQFPDFSLYRLQYEHASGNGTTSVTLPTIGLGFCLEGSAKVNGTTVNAGDCFAVPYGKLTCQAEGAKALVFVASTNDLSDR
214
Q7XPY5
3.2.1.21
ACT_SITE 254; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"
MARRRMGEEGKGGGWGLNGRQCRFGNRLRAVKGEGWRSAVAAQAATGRREEDDAGGREKGEKRERKGGLSPCLFGKRRRERRRGGRGRREALPPSLGGLRAERRGRGDDDVLINYNVQHVSRIKLEERLLITDKLSLRFLDPIFFGEYPREMREILSSNLPKFTPEEKKLLQNKVDFIGINQYTAIYAKDCIYSPCALNTYEGNALVYTTGVRNGAKIGKPTAFSTYFVVPESIESAVMYVNGRYKDTTIYITENGYSQHSDTNMEDLINDVERVNYLQGYLKYLSSAVRKGANVGGYFMWSLIDNFEWVFGYTIKFGLYHVDFDTQERIPKMSAKWYRDFLTGSNVTDDTQVWSRRADS
161
Q7S477
1.8.1.4
ACT_SITE 483; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MLSQRLIGRAAVRSAFKPSGLPVVVSPRLRRTYATESEEKDLVIIGGGVAGYVAAIKAGQEGLKVACIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDSKHRGIEVGDVKLNLAQLMKAKEQSVSGLTKGVEFLLKKNGVEYIKGAGAFADEHTINVKLNDGGETSVKGKNILIATGSEVTPFPGLEIDEKRVISSTGAIALEKVPEKMLVIGGGIIGLEMASVWSRLGAQVTVIEFLDQIGGPGMDLEVAKSIQKILKKQGINFKTGTKVVSGDKTGETVKLEVDSAKGGKPETLEGDVVLVAIGRRPYTEGLGLENIGLEKDERGRVIIDSEYRTKIPHIRCVGDVTFGPMLAHKAEEEAVAVVEYIKKGYGHVNYGCIPSVMYTFPEVAWVGQSEQELKKAGVPYRVGTFPFSANSRAKTNLDTEGMVKMIADPETDRILGVHIIGPNAGEMIAEGTLALEYGASSEDIARTCHAHPTLAEAFKEAAMATHSKAIHF
36
H2MUM2
2.7.11.13
ACT_SITE 336; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000554-1"
MPTLRDSTMSHPGENSHQVRVKAYYKGDIMITHFEPSISYEGLSGEVRDMCSMENDQLFTMKWIDEEGDPCTVSSQLELEEALRLYELNKDSELIIHAAEVSIYRRGARRWRKLYYASGHVFQAKRFNRRAHCAICSDRIWGLGRQGYKCINCKLLVHKKCHKLVTMECGRPVMQVRNTYSRESLEDYVEEKEARSSRDAGKSPSSLGLADFDLLRVIGRGSYAKVLLVQLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILNKQIRIPRSLSVKAASVLKGFLNKDPKERLGCHPQTGFADITGHPFFRNVDWDLLQQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDEDVVKKIDQSEFEGFEYINPLLMSAEECV
100
A0R2N3
2.3.1.286
ACT_SITE 104; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MQVTVLSGAGISAESGVPTFRDAETGLWAQVDPYEISSTDGWQRNPEKVWAWYLWRHYMMARVAPNEAHRTVAAWEDHLDVRVVTQNIDDLHERAGSTNVYHLHGSLFEFRCDACGSAFEGNLPEMPEPVETIDPPVCPCSGLIRPSVVWFGEPLPDAAWNRSVLAVSSADVVIVVGTSSIVYPAAGLPEAALAAGKPVIEVNPERTPLSDSATVSLRETASEALPTLLQRLPELLNRSA
58
F6I4A4
3.1.1.11
ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MFHQRPSSSHGGTPSKHLSWGCTIFLVLALTTAVSGLASSSHTSTVPKASMEAIVSAACKATFYQTACQSALLSSTNGAVPQTQADLFDLSVQFSLNQARSARAHVHDLRLLDHKTQIVRGTDDCMELLDDTLDQLTNVANRRKTLIEDPDDVQTWLSAALTNQATCLESIQTYQTGGQNGLMRPMAQNLTYSISNSLALHMSTRPSKEAQRTNTAGHHRRLLSDRFPGWVTAAERKLLEASVEEIGATAVVAKDGSGTHKTIGEALAMVVTLEGEGRTVIHVKAGTYDEGLKIPSSQKNVMLVGDGKGKTVIVGHKSYAGGSSTYDSATVGVMGDGFIARDITIENDAGPGKGQAVALRVGSDRSVVFRCSIIGYQDTLYTLSKRQFYRETDIYGTVDFIFGNSAVVFQSCNLNARKSSNNNFVTAQGREDPNQNTGISIHNCKITTEGSTTYLGRPWKKYSRTVIMQSYLDGSIPPSGWYPWSGSFALSTLFYGEYMNAGPGASTSGRVKWGGYQGELTASVAQEFTVGEFISGNAWLPSTGVSFDSGLIN
125
W5MIN0
2.7.10.2
ACT_SITE 1004; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
MSRISAMELGRQLCGKMRKTKKTEAIISTPMKGLEIHFYLCDSHQLEYLSGSYLVEDLCIEAAKKCGISPLCYNLFALYDESRNIWYPPNHTFTIDEGTAIKLHYRMRFYFSNWHGTNENESLVWRHSLHKQKTEYGPKKVPEGTPLLDAASLEYLFAQGQYDFLKGLAPVRSPQNENETHDIENECLGMAVLAITHHTMRKSMAGSAGETRKQINYKKYIPETLNKAIKQRNFLTRIRINNVFKSFLNEFNNKTVTDSNVTMHDLKVKYLSTLETLTKHFGTEIFETSMLQICVENESCLPYNKEQPLYEIQVSGKMGIMLREKPINIVFTQKEKNKSRKIRTESKKKNERKKDNLSDGWKLFSEFNNITHIVLRDSTVTIYTQDNKRMELQLAFHDEALSFTALIDGYFRLTVDAHHYLCTDVAPPTVVQNLQNGCHGPICTEYAIHKLRQEGNEEGMYVLRWSCTDYNSILMTVACIESDSCDMRPIRQYKNFQIEMGSHGYKLCGTDTFRSSLKELLEHLSGQYLRTDNVSFQLRKCCPPQPREISNLLVVTNNTAPETQSPLQDSQLSFHRILKEEIVQGDHLGLGTRTNIYVGILKVKSEDDEDGLYAVNEVKVVLKVLGSRHRDISMAFFETASMMRQVSHKHIALLHGVCVRDMENIMVEEFVESGPLDVFMRKERSHLTPVWKFQVAKQLASALSYLEDKKLTHGYVCTKNILLARKGLEYEGSPFIKLSDPGIPITVLSREECVERIPWIAPECIKNTSNLSVAADKWSFGTTLWEICYDGEAPLKDKKLTEKERFYAAECALVTPDCKELADLMKQCMNYDPKKRPFFRAIMRDINKLEEQNPEIVSGTMPSQEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPDMDRTGELVAVKSLKPENKDEQDTNLHREIDILKSLYHENIVKYKGICREEAGRTTKLIMEYLPAGSLKEYLPRNKQKTDLKKLLKYAVQICQGMDYLGSRNYIHRDLAARNVLVENENTVKIGDFGLTKTIKDNEGYYTVKDDLDSPVFWYAPECLVHCKFYIASDVWSFGVTMYELLTYCESECSPMTMFLKMIGPAQGQMTVTRLVKVLEDGKRLPCPANCPEMVYMQMKKCWEHAPEKRIEFKGLIEVFEGLIEKM
98
A0A9R0K3T4
1.11.1.7
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKRILSVIVICSLISHSQAALEVGFYRDKCPFAEAIINHEVKKSYLIDKGIAAGIVRLQFHDCFVRGCDGSIFIDSTPTNQAEKDGSTNESIRGLEVIYNAKDKLEAVCPGVLSCADILAYAARDSNVLSGGVYWDVPAGRRDGRISRASEIVDIPLPSFNLVQITESFANKGLTQADMVALSGSHSIGRSHCFQFTDRLYNHNTKTMQDPNLDPHYAQLLRIVCPKVLQEIFNQTLVVGMNQSPFYMDSSYYGNLFKHAGLFVSDQSLLDSQTTATQAASYAANDLSWKVDFAQAMIKLSQVQVLTGNQGEIRANCRVINP
14
A0A803T1T9
1.11.1.6
ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MECHRDYAKEQLEHWQEQCGRQGPPALTRAAGIPVGNHRNVLTVGPRGPLLVQDVVYAEQITHFDQERIPERVVHAKGAGAFGYFEVTHDITQYCKAILFEHIGKRTPIAARLSAVVGESGSADTVRDPRGFSVKFYTEDGNWDFVGNNTPIFFIRDPMLFPSLIHSQKRNPQTHLKDANMSWDFFSLRRESLHQVSFLFSDRGIPDGFRHMHGFGSNTFKLVNACGKAVYCKFHAKTDQGIKNLTVEKAEKLASKDPDYGLRDLYNAIANGDYPSWSFYIQVMTFEQAETSPFNPFDVTKVWPHGDYPLIPVGKIVLNRNPVNYFAEVEQIAFDPSNMPPGIEPSPDKILQGRLIAYQNTQKYRLGSNYLQIPVNCPYRTRVANYQRDGQTSISGNQGGAPNYYPNSFSGPEDWPCLEESCENISGDIRRFNDDNDDNLSQVRVFYTKVLTEEERERLCENIAGLLKDAQLFIQERAVSGKLLHSVSSDFSGKTSIVRIFESKGYTQMSECIEIQNAKVLMHEWKEKRY
13
A0A1D5RIZ5
2.1.1.37
ACT_SITE 643; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MEPSPEPPSLESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPCPSPASSYLTIDLTDDTEDTRVTPQSSSTPYARLAHDSQQEGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPGVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
47
P35992
3.1.3.48
ACT_SITE 1468; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044"
MLYQLSKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNKPSSMICKDSKGGNIDVLESQQQQQQQQQQQPNQGGHNITTISAINGYNTLQHRRKSQLITFSSSSCDIKNSLSHEYINGSNGSAANGPPSSGSGSGSGPGSNRASRANVRLSFAEEDVMILPQNHSQQSNHQDDEVFTRRRSLLEVEIGVEVGEDGELAPHEMEEDLEEEDEDEELYMHDEFETHIDTKSNNANDDSGGGSYEDSHALHSSLGGSNRNSLEKDDDDIEVDVISTDVSCYDQLLGSSCNTRNGDDDDIATLVGDGDYSTTKLSKASRLSGAGVGGLVVSGGGGGTAIGGGIAVNGGGVLGNGVGSEAGGGIIYANPFMDDEGIAESGM
149
A0A0D1DRT0
2.7.11.23
ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
METAAAQNLLIANSYAKVEKVGEGTYASVFLARSINTGQKVAIKKIKIVSNENGMDVTAIREVKFLKELNHPNVIKLVDVFSSGSRSPSLNLVLEFLDTNLEALIKDRTLIFTQADIKSWMAMLCRGLEYCHRYWVLHRDLKPNNLLISPQGELKIADFGLAREHGDPGARMTHQVVTRWYRPPELLLGSRAYSSAVDMWSVGCIFAELMLRVPYLPGESDADQLITIFKALGTPTDKDWPGHKSLPEYTAFEQYPKSNLADLFLAASPEALDFLQKMLLFDPLKRLSANQALHHAYFKQGPPPTPFKQLPRHPTKALDSGDPAAHPLLSDSKEKNEVREKQQNQAHGNGNVNGNSRKRPFDAKEIEERRRLARKLAFA
103
B9IJU9
5.1.3.3
ACT_SITE 193; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MAKVTVLLCFCILAVFGSVNAHTGKEKVGIYELKRGDMSLKFTNWGATLVSFVLPDKNGKLIDIVLGYDTIKQYKNDTTYFGAIVGRVANRIKGAQFKLNGHTYKLVPNEGKNMLHGGPKGYADVVWEVTKYQNKGHKPHIVFSYHSFDGEEGFPGEILVTVRYTLLADNQVTVVMKAKNIGNKATPVNIANHAYWNLGGHNSGDILSEKIQIFASNYTPVDNDLIPTGKIEAVKGTPFDFLKPEAIGSRTRQLPKGYDINYALDGVHGGKIRKAAVLQDEKSGIEMELSTNAPGLQFYTGNMIKDVKGKAGFVYKAHAALCLETQWYPDYVNQPDFPQSIVEPRKNYKHVMLYKFSSH
211
A0A067H5N1
3.1.1.11
ACT_SITE 404; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASKLFFLITIPILIALPFFAYPSYAADNVDPPTTPVPPETICMYTPKPKDCKSVLPATPNQTADTYTYCRLSIRKALSQTQKFFNLVDNYLKSGSTLPLSAIRTLDDCRLLAGLNLDYLSSSYQAANTTSRILKTIQADDVQAQLSAILTNQNTCLDDIQDSALSESVKNGLSVPLLEDIKLSSVLLALFRKGWVGEKKIVTSWQPSKTQSMFGHNGRLPLIMSDRIRAIYDSVRGRKLTGGDEGVLVIDIVTVALDGTGNFSTITDAINVAPNNTNPDNGYFLIYVTAGVYQEYISIPKNKKNLMMIGDGINQTIITGNRNVVDGWTTSNSATFIVVAPNFVASDITIRNTAGAVKHQAVALRSAADLSTFYSCSFEGYQDTLYTHSLRQFYRECDIYGTVDFIFGNAAVVLQNCNIYPRLPMSGQFNAITAQGRTDPNQNTGTSIHNCTIRASNDLASGSQTVQTYLGRPWKEYSRTVYMQTFMDSLINPAGWHDWSGDFALSTLYYAEYNNTGPGSDTTNRVTWPGYHIIDATEAANFTVSNFLSGDNWLPQTGVPYNGGFIS
125
C3Z724
2.3.2.23
ACT_SITE 97; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MSGSSNVENLSPQIIRQVAKEVLDLANHPPEGVKVFPNEQDITDVQATIEGPGGTPYEGGQFKIKLSLGKDFPQTPPKGFFLTKIFHPNVAKNGEICVNTLKKDWKADLGLKHILLTIKCLLIYPNPESALNEEAGKLLLEQYDNYSERARMMTEIHAKPTTKTAPTKNEETNCPSTSGTQSTSEGPMAKKHAGDKNAAEKKKKEKKRALRRL
64
A0A3Q7EGN4
1.11.1.7
ACT_SITE 105; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKILFSVAWDDAKNEDYSRKSTWGARNDEDVPRNEENGERNAWGLSNAWDALKNVWGPRNSNVPRKNYYQSTHCPNVEQLIRDITWSKVAQDPTLGAKLLRIHYHDCFVKGCDASILLDKVGSDDSEKEARPNLSLAGFEVIDDIKREVESKCPGIVSCADILALVARDAVSYPFKTSMWEVETGRKDGFVSLASNVNGNLPSPFSDFATLKQIFANKGLNVDDLVALSGAHTIGVAHCGAFSRRLFNFSGKGDMDPSLNATYAKDLKDVCPNPANPATIVEMDPMSSTSFDSNYFNILINQNKGLFQSDAALLNDKDSVIVIKKLQDDNTFFSEFAKSMKKMGAIELLTGNAGEIRKNFVAGARNVLRNNFYKSAPCPNAEQLIRDITWSKAKIDVKLGARLLRLHYHDCFLRGCDESVLLDTEGTEQSEKEAVPNLSLGGFDVIDDIKKQVEAKCPGIVSCADILALSARDAVSFPFKTSMWGAETGRKDGNVSLASEVLIQLVVAHCGTFSKRLFNFSGKGDIDPSLNATYAKDLKDVCPNPANPATIVDMDPLSSTSFDSNYFNILINQNKGLFQSDAAFLNDKDSVIVIKKLQDDNTFFFEFAKSMKKMGAIEVLTGNAGQIRKNCRVKN
14
A0A9K3N4X6
1.11.1.7
ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MYEVYLSPCFLAPPYMVDFQSPTKTIYTDPPCNVSTSTSHLRNTLLNLKDKSLLLLLMEISSLSKTVALLVLLLATLTTLSLGQGNRGSGRGTRLGYYRSSCPRAESIVQSAVRSAVQANPTIAPGLLRMFFHDCFVNGCDASILIDGPTTEKTAGPNSLLRGFEVIDAAKSQLETACPGVVSCADIVALAARDSVVLTGGRSWQVRLGRRDGLVSQASDTANLPAFNDPISVQIRKFADKGLNTQDLVTLVGGHTIGTAASCPGVISCADIVALAARDSVVLTGGCSWQVRLGRRDGFVSQASDTANLPAFNDPISVQIRKFADKGLNTKDLVTLVGGHTIGTAACALFSYRLYNFNNTNGPDPDINPAFLPQLRALCPNGGDALRRVALDTGSDNSFGNSFYENLRNRRGVIESDAKLWSDRRTQRFVQRYLGERGQTGSRFNAEFGRAMVKMGNIEVKTGTQGEIRRVCTATN
14
A0A0K9NY40
3.1.1.11
ACT_SITE 367; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MDFKTVFFFLSSITIFSVISVTGGNSTFQVAQIHCNGTLYPSLCMSMVSSIPEVKSKSLPHVISHIIAHTTIAVRRSSRKCSKLLHKRHRHLQLRQRLALTDCLELFDSTIEDLESARFDMLSTTDVSSYYHDLQTILSAGITNQGTCLDGFSDDSLRYSISKGVRHISQLVSNSLAMSKKLDNGAGSEMFYRGGFPEWMTRKDRRLLQSPLESMKIDLVVAKDGTGDYKTISEAVAAAPNKSKTRFVIYIKKGGYFENVDVPSYKPNLMFIGDGMWKTVVKSYRNVVDGWTTFRSATVSVVGNGFLARDMTFQNSAGPSKHQAVAFRSDSDLSAFYRCSFAAFQDTLYVHSFRQFYRDCTVYGTVDFIFGDGAVILQNCQLYARKPNPGQMNIFTAQGRQDPNQNTGISIQNCKMAAASDLIPVQHSFKTYLGRPWKKYSRTVVMGSYLDDLIDPSGWKKWSGNFALSTLYYGEYNNRGPGSNTKRRVTWPGYKVIVNTTEASQFASGTFIQGEDWLPLTTFPYASDV
125
Q6PEE3
1.17.4.1
ACT_SITE 138; /evidence="ECO:0000255|PROSITE-ProRule:PRU10014"
MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
21
A0A251Q650
5.1.3.3
ACT_SITE 229; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 360; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MPLTLFSCKPINLFNSPHPIKLLSHIFSFFAKNNMAKICVLLCFILLAASGFANVSGSEPKEKKVGIYELKKGDLSVKFTNWGATIISLVFPDKNGKLADVVLGYDTIKEYTNDTSYIGAIVGRVANRIGGAQFTLNGTHYKLVANEGKNVLHGGLIGFSDVVWKVQKYQNEGDAPHIVFTYHSADGEEGFPGDLLVTVSYTLLGDKQLSVKMKAKALNKPTPVNLAQHTYWNLGGHNCGDVLSQYIKIFASQITLVDSHLIPTGKFASVKGTPYDFLKPKAVGSRINKLASGYDINYVLDGGAGNKLKPAAVVYDKKSGRVLELSTNAPGLQFYTSNFLKDVKGKGGFVYEPHAALCLETQGFPDAVNHPNFPSTIVTPKKPYKHNMLFKFSTKAPYAS
211
B9SRK8
2.3.2.26
ACT_SITE 1136; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MDEPRRHQVSLRGASAREISRDALLEKVYHERELRSYARRATASAIFIQRVWRRYIVTKKVAFQLQEEWESMLNHHDGSITASWISNSLLRPFLFFVACSSTRHQKICTRDIYCMQTCFKILLESINCTDSRKNFCSLSVGSLEERRMWTFQSKKLICLCSFILSECDKSHAVGHDIVVLTSVAMHFLVVLTDLNGWKGTTNSNLEDTNVAVNHLIRFMGSCKSGLYISIRTFINKLDIHVSSQTKNMVQTDDKFLITATAVTLALRPFHASSLKVTGSDLLDMDSAVVQYFLFILTIPRLIQRLPAVLLSALKHKSILSPCLQTLLILRDNILTEMMQMDHPKMQRSSKVIPSVGWALANIIGLAAGSENDFMDPGRLNQSLEYAFYVRVVTILAESLLSWLHGSRWTEKDNQCPEVNADSSAEPVGHVLDENETACALKMNFVDLLRPASQQWHLKKLLAITKTDAYNQTDETSTAQNSKYLRKLELLDIAHFYSYMLRMYSILNSSLGPLPILNMLSFTPGYLATLWEALEKLLFPQKGHITADDGFAASKISGNKKDGDSEKKQRHLNKDGGNKWANVLHKITGKSQAGVDFTGSVDGEPSEQVEEDLQDVWDVELLRSGPQKISKDILCLLHLFCATYSHLLLVLDDIEFYEKQVPFTSEQQRRIASVLNTFVYNGLAHSADQQCRSLMESAIRCLHMMYERDCRRQFCPPALWLSPARKSRPPIAVAARTHESVLSNLKPDDALTVPSIGSVITTIPHVYPFEERVQMFREFVNMDKVSRKMAGEVTGPGSRAVEIVVRRGHIVEDGFRQLNTLGSRLKSSIHVSFVSECGVPEAGLDYGGLSKEFLTDISKASFSPEYGLFSQTSTSERLLIPNPSAKYLENGIQMIEFLGRVVGKALYEGILLDYSFSHVFVQKLLGRYSFVDELSTLDPELYRNLMYVKHYDGDLKDLFLDFTITEESFGKRHVIELKPGGKNVSVTNENKMQYIHAMADYKLNRQILAFSNAFYRGLTDIISPSWLKLFNASEFNQLLSGGDFDIDVDDLRDNTRYTGGYSEGSRTIKLFWEVIKGFEPNERCMLLKFVTSCSRAPLLGFKHLQPSFTIHKVACDASLWATIGGQDVERLPSASTCYNTLKVLVIQGS
65
B9RA19
3.1.1.11
ACT_SITE 223; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAKQITYIAIIHYVIAAILLAATTVISDDATPIPAAENQVNSWFQANVKHFSSRKGTLDPALLAAEAAPKRIKVRLDGSGDFKSVTDALKSIPSGNEHRVIVDIGCGVYTEKVTIDRIKPFVTLLGSSKHMPTLQFAGTAKKYGTVYSATLTVEADYFVAANIIIKNTAPRPDGRAGAQAVALRVAGDKAAFYNCRILGFQDTVCDDKGRHFFKDCYIEGTVDFIFGSGKSLYLKTHLNVIKEKFMTVITAQAKHTSSEDSGFSFVHSSITGDATDAYLGRAWMEMPEVVFSYSKMSKVVIPAGWSNYNHPEREKNILFAEYKCSGPGANPSGRVKFSKQLSDSAAKRFISLGYIQGSKWLLPPPS
125
Q57690
4.1.3.27
ACT_SITE 80; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 168; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 170; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
MEVKKVLVIDNIDSFVWNLVQYVGTLGYKVKLVDNKITLDEIKKINPDRIIISPGPKTPKEAGNCIKIIQEVDIPILGVCLGHQCIVEAFGGEVGRAKRVMHGKASLINHDGEGIFKDIPNPFYGGRYHSLIAKEVPKELKITAKSLDDNYIMGVRHKKLPIEGVQFHPESILTESDNLKFPDLGLKLIKNFVESEY
198
A0A1L8GKJ1
3.1.1.4
ACT_SITE 77; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 128; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MRSRTVLALLLTVHFFALVSSALTHRQSRNLAQFSNIIKCAIPGSRPLLEFNNYGCYCGLGGSGTPVDELDKCCQIHDNCYDKAKHMNCIPVLQNPYTETYSYTCTDNNMISCDKNNSECDMHICNCDLNAALCFSRASYSKKHKNLNKDKHCQ
130
A0A0A0KGQ9
2.4.1.18
ACT_SITE 425; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 480; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MLLSSCVLPSTAVASLSLSAKKIIISDSRNQWPSLRQQTELNFWSRMSHHRQMNPFVFPYSTYKRVHSPAISSVMTEDTSTVSSTDESMENIGILSHDPGLKPFKDHFKYRVGRYTDLLNLLDKHEGGLDEFARGYLKFGFNREEDGIVYREWAPAAQEAQIVGDFNGWDGTNHCMEKNEFGIWSIKVYDLGGKPAISHNSRVKFRFKHGNGVWIDRIPAWIKYATVDPTKFAAPYDGVYWDPPPLERYEFKHPRPAKPNAPRVYEAHVGMSSSEPRVNSYREFADFVLPRIKENNYNTVQLMAIMEHSYYASFGYHITNFFAVSSRSGTPEDLKYLIDKAHGLGLRVLMDVVHSHASNNVTDGLNGFDVGQSSQDSYFHTGDRGYHKLWDSRLFNYANWEVLRFLLSNIRWWLEEYQFDGFRFDGVTSMLYHHHGINMGFSGNYNEYFSEATDVDAVVYLMLANNLTHSILPDATVIAEDVSGMPGLGRPVFEGGIGFDYRLQMAIPDKWIDYLKNKSDEEWSMGEISWNLTNRRYSEKCISYAESHDQSIVGDKTIAFLLMDKEMYSGMSCLENASPVVERGIALHKMIHFITMALGGEGYLNFMGNEFGHPEWIDFPREGNGWSYDKCRRQWNLPDTDHLRYKFLNAFDSAMNALDEKFSFLASSKQIVSWTGEEDKVIVFERGDLVFVFNFHPVNTYDGYKVGCDLPGKYRVALDSDASDFGGHGRVGHDIDHFTSPEGIPGVPETNFNNRPNSFKILSPARTCVVYYKVDESKEKEKDDLVGSANEDVFARHVEEDSEGLAGCKEENDIAVGEISKTEDDDIDTSKPEDDDVDSNKIEDLPVRGE
73
Q7SD45
2.7.7.7
ACT_SITE 551; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MSFQTLAEKVAFFEVLDALSETISDDEKFDTQEQEHRARSKAFFSSKAKPKPKSNPNIPTIPQTQPPAATLSTPLSKTSSRVDIIKATPGARDLRKTALKNTTDTPSVSDTSLVVTETPQPSTSSARPVPPLLQRSATLPIPSTTRLVSSPHHQQSPSGTSSTRKRKRQAEANAVPEADQIFRTLMFFYIPNDNVAPARRLRIARAQQYGAKWVRSLEKATHVIVDKRLAYHDIQSVLEATPTTSAPVIVNEDYPIDCIQFRTILNADQARYHIPGRPHPASPTLIAQATDTHAPSQISNRSLQVKVSTAKRRKQVPSSQDKTQSQSEESVPLAESIDVQEKGAKPVAEEQIVEDVADDDYIPEPRPPIIPSLLSGGPRLTSSLQKISPHHQDDSPEDDPKDELSGCIELLQQYKDLPLDGPLEDDAQSVISCQEEIISESEIEEGSPHERTQQRRSQRTRRPTQKQIASEDRFACNKGGTKDKAAEAQNPNARTIEVLQSMCDYYSRVSDQWRTTAYRKAIATLKRQNTRITTADEAYHLPSIGKRLAEKIEEIVTTDSLRRLEYAQASPLDHVLATFLKIYDVGNGRANKWISQGFRTLDDLKQKANLTHNQRIGVDHYEDLNTRIPRREVTAIGDYIKKEAAQIDPAVELLIGGSYRRGAESSRDVDFIITKKNTTSSADLVPFFERLLKVLTDKGCVVATLSALHADRKGKDGPGSKWLGCCVLPRADGPTSDKMITRRSAKSASSSTPRPIWRRVDFLLVPETEYGAALIYFTGNDIFNRSMRLLASKKGMRLNQRGLYKEVMRGRGRVKVTEGQLVEGRDERRIFEILGVKWREPEERWC
121
W5MKZ4
2.1.1.37
ACT_SITE 1223; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016"
LFVKQTKFKLEMPAKTSLSLPEDVKKRLQVLDTDGDGLTDEERVRETLSLVLGYLKADAQNQLNNLESKLKKEELSVEGYLSKVKALLGRELCLENGSSELNGQANGCAENGAHGASDEDCGPRNGQGAEGTVEAREEEGLKSPSTGKPRGGRRSKTEGDTKIYVSLSPGVLRGWIPNCVMYTNPFYNQSSFPTGGVPCDTLVGESGKCWRTLAIRKQGGRRRRNSEPGRMLRQISESFSSSRVTRNSVKQPTILSMFAKSSSQPTSLGLLFNVFSIVESPLPSSSKRKSDEVNGEEVAPVTEEGVTDDEEKAQDEKRLKVESEEKTDTKASVQKNPVPPAKTPPPKCPDCRQYLDDPDLKFFQGDPDDALDEPEMLTDERLSLFDANEDGFESYEDLPQHKITNFSIYDKKGHLCPFDSGLIEKNVELYFSCAVKPIYDDNPCMDGGVPAKKLGPINAWWITGFDGGEKALIGFTTAFADYILMDPSEEYAPIFALMQEKIYMSKIVVEFLQKNPEATYEDLLNKIETTVPPAGLNFNRFTEDTLLRHAQFVVEQVESYDEAGDSDEQPIIVTPCMRDLIKLAGVTLGKRRAARRQAIRHPTKIEKDNKGPTKATTTKLVYQIFDTFFSDQIEQNDKESSAKRRRCGVCEVCQAPDCGKCTACQDMIKFGGSGRSKQACLKRRCPNLAVREAEDDENIDEDDVLPVQTTPKKMSQAKKKKQSKSKLSWVGEPVKTVGKKDYYMKVSVEDEILQVGDCVSVSPDDPSKPLYLARITALWEDNNGKMFHAHWFCRGTDTVLGESSDPLELFLVDECEDMQLSYVKGKVNVMYKAPSNNWFMEGGMDSEIKVIDDDGKSFFYQLWYNPEYARFETPPNVSPAEDCEIMFCDSCTRTKELMEQEIPRVLEPLSEDHDSKVFYGLACLRGEQYRVGDGVYMLPESFSFSVKSASPVKRPHRKDDVDEELYPEYYRKSSDYIKGSNLDAPEPFRVGRIKEIFCLKRSNGKPNETEIKLRLYKFYRPENTHKGPKAGYHTDINMLYWSDEEVTVDCKDVQGRCTVEYGEDLIESVQEYSSAGPDRFYFLEAYNSKTKSFEDPPNHARSASHKGKGKGKGKSSSSTVQEQLDQEPQDLKPHKLRTLDVFSGCGGLSEGFHQAGVAETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSYLSYCDYYRPKFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPKYPEPLHVFAPRACSLSVVVDEKRYVSNITRVNSGIYRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQIRGSQYQPILRDQICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTTTKKLRYTHSDKKNGRSSSGALRGVCTCAEGKPCDPADRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVSLVDLQKCF
47
F6VF91
4.1.1.50
ACT_SITE 75; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 89; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 243; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 257; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MSVVDVKDGAPQSWFFEGVEKLMEIWFSSSAPDGPKKGANLIERWKWENILTHVHCKILDEMKHQDQTAYILSESSLFVSRERIILKTCGTTLCLQALPFIIQLVQDECGFDTVADFFYSRKNFIKPDNQPHPYKTFQDETVYLDTILSESASYCLGRMNRDCWYLYTLNHPENTSLIGVNQPDQTLEILMTNLSVESMQKFTRCDEKGNVRNAAKFTEDIGISDILPGSKINSILFDPCGYSMNGLLDKNQYWTIHVTLEPEFSYVSFETNVIMKDYKELIGKVLNLFQPQVVSMTLFANHVSKNKVHKSFYIKVPGYKRLDRQVAQLQDYSLWYSQLKKEIKNNGV
196
K3YZ47
3.1.1.11
ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
METFGGATSPERQAKMRLPVVAWSCAMATVLALGTVVPVAEARKGDDNVAAVSRICRSTPYPSACETALTSAEARRARDPFAASVQFAMARARTARSLARNLSASAPPTAMHDCAELLDISLAQLRDALAGRAADAAGATTWLSAALTNQGTCNDSLAAAATPKALAAGRGAVRKQVAALAQFISTALALHVKRVKGGRGVPPSAATAAPSPKSSTFPSWLSEHDRKLLESPATDVITADAVVALDGSGTHRSINEAIAAVTSPVDTEAGGGREAGRARRKVIKVKAGRYKESVSISYQQENVMLVGEGKGKTIIDGNKSVAGGYTTYSSATFAAMGAGFIAKGVSFVNSAGPGKGQAVALLVGGDRSVVYQCEIKAFQDTLFTHSNRQFYAESDISGTVDFVFGNSAAVFQSCELQARKPIPGQQDVVTAQGRVDPNQNTGISIHRCRITAASDLGNTPVYLGRPWKQYSRVVVMETTMDGSVAPDGWLAWPDQPTPSTTLYYGEYRNSGAGAGTKGRVTWTGVHTSMSTADATGFTVAKFIMGDSWLGATGVRYTSGL
125
G1KJ78
3.5.1.98
ACT_SITE 859; /evidence="ECO:0000256|PIRSR:PIRSR037911-1"
MSSQSHPDGLSGRDQPVELLNPTRVNHMPSSVDVTTTLPLQVAPTVVPMDLRLDHQFSIPVAEPTLREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEILAMKHQQELLEHQRKLEQHRQEQELEKQHREQKLQQLKNKEKGKESRHLFDDSLNTVLMEIKNPVKMEDEKLKTSHILLFQAQARPGTAVPQQKVYLGAVASTEVKMKLQEFVLNKKKALAQRNLNHCISNDPRFWYGKTQHSSLDQSSPPQSGVSGNYNHPVLGMYDSKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACNSAPGSGPSSPNNSSSNISAENGITPSVANIQAENNLAHRLANREGSVTQLPLYTSPSLPNITLGLPATAPSSGGSGQQDPERLALPSLQQRISIFPGTHIPPYLSSTTVDRDGGNAHNPLLQHMVLLEQPSTQTPLVPDWYLSGLGALPLHAQSLVGADRLSPSIHKLRQHRPLGRTQSAPLPQNAQALQQLVIQQQHQQFLEKHKQQFQQQQLHINKMIPKPNESSRQHESHPEETEEELREHQAFLEDPYIDRISNQKDIQGLTSMVQVKQEPVESDEDGEFQPELEPGQRQAEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASANFPISVQEPPCKPQFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRSKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLTSVFVRLPCGGVGVDSDTIWNEVHSFSAARLAVGCVIELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAISAKLLQQRLNVNKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGSGAPDEVGIGPGAGFNVNMAFTGGLDPPMGDTEYMAAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPAPLGGYNLSAKCFGYLTKQLMGLAGGRIILALEGGHDLTAICDASETCVSVLLGNELDPIPEKVLQQRPNANAVHSIEKVIEIHSKYWHSLQRYASTVSYSLTEAQKCENEEAETVTAMASLSVGVKPPPDKKPDEEPMEEDPPL
184
A0A3B6AR18
2.3.2.26
ACT_SITE 1915; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
METRSRKRAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPAHPAPTRARRSVVLSPPAPQPPMDFPADGGNNPPPRRRGGRASNADKGKEQQEPSESSRVREAERMLGLSFDGMDDDDEGHGAFPHGLTSASSALQGLLRKLGAGLDDMLPSSALSAAAAAASSSSMSGPNGTRMKSMLAGLRADGEEGRQVEALTQLCEMLSIGTEDTLAGFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCSAVVHYGAVACFCARLLTIEYMDLAEQSLQALKKISQEHPTACLRAGALMAVLSYLDFFSTGVQRVALSTAANMCRKLPSDASDFVMEAVPLLTNLLNYHDAKVLEHASVCLTRIAESFASSPEKLDQLCNYGLVAQAASLIAVSNSAGQASLSTLTYTGVIRVLSICASGSPLAAKTLLLHGISGTLKDILSGSGLVAGTTVSPTRPADQMYEIVNLADELLPPLPAGTISLPAHSHVFMKGSSVKKPGSSKQGESGSTDIKVSGREKLLRDQPELLQQFGMDILPTMTQVYGSSVNGPIRHKCLSVIAKLMYYSSAEMIEILHGTTNISSFLAGILAWKDPHVLVPALQIAEILMEKLPGTFSKMFVREGVVHAVESLICQEISSPMLFQVPQQDKDIDSGTCTSSRSRRSRRRSSAGNTDNNSLDEPKGSHTTIANSPPSTLEGPNTRIRASVSDRAKSFKDKYFPSEPGSSDIAVTDDLLKLRALCAKLNATADTVKTKAKGKSKSLGGDDFDILCNVEEQLDDIIDKILSELSNGDGVSTFEFIGSGVISALLNYLSCGTFGKEKVSEANLPKLRHLALRRYKAFIYVALPNDAVGNQTPMAFLVQKLQSALSSLERFPVVISHSGRTSSLGGSRPSSGLSALSQPLKLRLCRAAGEKTLKDYSSNIVLIDPLASLAAVEDFLWPRIQRSESISYPAVSSGKNSESVAPSATAPVASSTQSVRRPSTRSKSLADADSATKKDIQEGSGNTSKGKGKAVVKSMSDEPKGPHTRTAARRKVASQKDAEVKPPHGHSSSEDEELGASPFEADDALMLGDDDDDVSDDEDDDHEVLRGSLPDCVPESVHDVKLADADGSSIASIASDNQTQPSSGSSVKHTFSSRGAGSVELRNPSTLGSRGAMSFAAAAMAGLASVGSRGIRGSQDRRGLPLGTSAHEHSNKLIFTAGGKQLSKHLTVYQAMQQQVVHDEDDEERLGGSDLPNDGSRLWSDMFTITYQKADNEVDRESTRGSSLVLKSSKSELCRATSQEQCTSLLDSILQGELPCDIEKSTQTYNILALLRVLEGLNQLSPRLRLQATCDDFIEGKVGTLDGLYGTGAKVPSEEFISSKLTPKLARQIQDVLALCSGSLPSWCYQMTKACPFLFPFETRRQHFYSTAFGLSRALNRLQQQQGDNNSSATEREVRIGRLQRQKVRVSRNRILDSAAKVMEMFSNQKAVLEVEYFGEVGTGLGPTLEFYTLLSHDLQRVGLGLWRSDSDSLEAKKLDSHSPADSRNLIHAPLGLFPRPWPPSTASSEGSKFFKVVEYFRLVGRIMAKALQDGRLLDLPLSTAFYKLLLGQELDLYDILSFDAEFGKILQELQVLVERKRFLESCSNHSQQIEELGFRGAPIQDLCLDFTLPGYPDFVLKEGEENTVVCIYNLEEYISLVVDATLKTGIMRQVEAFKAGFNQVFDISSLQIFSPQELDYLICGRRELWEPETLVEHIKFDHGYTSKSPAIVNLLEIMTEFTPEQQHAFCQFVTGAPRLPPGGLASLNPKLTIVRKHSSTAANTSNAAGAAESADDDLPSVMTCANYLKLPPYSTKEVMHKKLLYAINEGQGSFDLS
65
D6X017
4.2.1.11
ACT_SITE 219; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 353; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MKRTFSSAAKTLVKKIQARQIFDSRGNPTVEVDLVTDLGLFRAALPSGASTGVHEALELRDKDKANYHGKSVFKAIKNVALIAPEVIKSQLCVTQQCQIDEIMVNLDGTENKSKLGANAILGVSLAVAKAGAATKKVSLFKHLADLAGNKDIILPVPAFNVINGGSHAGNKLAMQEFMILPTGAKSFTEAMKMGSEVYHHLKNVIKAQFGLDATAVGDEGGFAPNIQNNEDALNLIIEAIKKAGYEGKIDIGMDIAASEFYKDGQYDLDFKNPKSDKSKWISGEKLLEMYKGFIKKFPVVSIEDPFDQDDWTSWSAITSSTDIQIVGDDLTVTNPKRIQTAVEKKACNCLLLKVNQIGSVTESIKAHLLAKSNGWGTMVSHRSGETEDTFIADLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEELGTKAKYAGRNFKFPHK
200
A0A251VCX8
3.1.1.11
ACT_SITE 416; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTTTFTFIATLVSFLLPLVAAYGYNDLEITSWCGQTPHPESCNYFLANNQYYSGPVIKQKPDFVKALLKVTLERAQHAESNTRGLGPKCRNKLEKAAWDDCIELYEHTVERLNMTVDPHKPCNQYEMQTWLSTALTNLETCRAGFQELGVDGYMLPLMNNNVSSLISNTLAMNKEGGSPPDNYQKGGFPTWVKPGDRKLLQSSNPASQANVVVAQDGSGNYKTIGEAIAAAAKRSGSGRYVIYVKAGTYKENIEIGTKLKNIMLLGDGIGKTIITGSKSVGGGATTFNSATLIVVGDGFIGRGITVRNTAGPQNHQNIMLLGDGIGKTIITGSKSVGGGSTTFNSATLIVVGDGFIGRGITVRNTAGPQNHQAVALRSGSDLSVFYQCSFEGYQDTLYVHSNRQFYRECDIYGTVDFIFGNAAVVFQNCNIYARNPPNKTNTVTAQGRTDPNQNTGISIHNSRVMAASDLKGATGSVKTYLGRPWKQYSRTVFMKTFLDGLVDPAGWMPWSGNFALDTLYYGEYMNTGPGSSTTKRVNWKGYRVITSSTEAANATEAAKFTVGNFIAGGSWLPATNVPFTSGL
125
Q9XTC6
2.7.11.25
ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:O43318, ECO:0000255|PROSITE-ProRule:PRU00159"
MDNSSQSKPSSSSSSHSPSPAAITPTQRTTRDSGLCSTIDIPEIQAQCIDNLNSHYLGKGTYGLVEKTRYRKTRQDDFRPAAIKYSSQLHMATLIREAKVMWDLRNHPNIIKIYGLYKSPRNGQGVVMEYMDCGSMADLLYDRTHINYTIDHVASWMFQLSSAVDFFHSNSQVHRDLKLQNMLLSDRYRTMKLCDFGTFTSMHQSMTSNRGTPITMAPEVFRCEQYNMKSDIYSIGIIMWQIIARNHPYRRDLSVPGLLYNVATANLRPQELECNPILSEFYKKCWNDNADIRPTSSECVEYFTLLKDEYPNGSVPLSDSSTNGPAETPPPHAHRPTMLGTSSGSGIGSNNRTPTASKLLNPQQPGQGHRRNRSETFVVQPDLPYPTVPGEAGASRIPKSQSEAKNFRDRAKSEQRQPHRDARPPPPFEHRRDSNDEEKHAVFMNICSNEETRPIDPDTRDEKSLEIFHQHCDNNKQYADAWVIKKEVMRAKHELIAQWPQHDHTVELLERKYYLEQEIARYRDIQDDNYFSTERM
105
Q6R3M4
2.7.7.7
ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00216"
MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALPEGVDQEVFKQLPADIQEEILYGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDSAEEKLPFPPDIDPQVFYELPEEVQKELMAEWERAGAARPSAHR
121
Q02157
3.1.1.3
ACT_SITE 170; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"; ACT_SITE 281; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
MLLLWALPLLLGAVAGLEVCYERLGCFGNRIPWSGGTLERPFSTLPSTPKIVNTRFLLYTNENPNNFQEISADASTIRGSNFRTDRKTRFIIHGFTDKGEENWLSNLCENLFQVETVNCICVDWKGGSRTTYPQATQNIRIVGAEVAYLVGTLQSSLGYSPSNIHVIGHSLGAHAAGEVGRRTNGTIGRITGLDPAEPYFQGTPEIVRLDPSDAQFVDVIHTDAAPMVPNLGFGMSQTVGHLDFFPNGGKEMPGCQKNVLSQIVDINGVWEGTRDFVACNHLRSYKYYADSIVNPNGFAGFSCASYTAFSANKCFPCSNGCPQMGHYADRFSRKTDGVGQTFYLNTGDSSNFARWRYQVAVTLSGRRVTGHVLVSLYGSKGNSKQYEIFTGLLKPGDTHLNEFDSDVDVGDVQKVKFVWYNNVINPTLPKVGASQITVEQNDGRVFKFCSTDTVREDILLTLTPC
128
A0A059AD62
2.2.1.1
ACT_SITE 490; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MAISSLLHNQYPSFCSYRRSKLSAKSIACSSLKTQDCKPAAQRSSLSRDDKLSWKEELKKAYQREIPNLNWDKLEELEDESFQNLVDKRCVDNVRMLIVDSVQNAKAGHPGMALGMAGVLFLLYRHVMKYNPKNPKWFNRDRFVLSAGHGCLLQYVCLHLAGFESVQIEDLKRLCQLGSRTPGHPENVVTSGIEVTTGPLGQGVANAVGLALAEAHLAARFNKADAVIVDHRTYCIMGDGCAMEGIAHEAASLAAHWKLNKLTLIYDDNHNTIDGPTTLAFSEDISARFKALGWHTISVDDIDADMRTLKDALFSAFSETEKPTFIRVRKLSGKEGTSKAHHGTFSEDDVNNMRQKVKWTDREPFHVIPIVYREMQKQADIGERLEKEWHTNLYSYQIKYPQEAIEFQILLSGGLLPGWENSLPRWSQSDPVDATRGHSEKCLNQLAKVLPGLIGGSADLATSNKAYLHNYDDFLPSSPWGCNIRYGVREHAMGGISNGIALHGSGLIPFAATFLIFSDYMKNTIRLAALSHAGVIYIMTHDSIGLGEDGPTHQPVEQLAGLRAIPHLLVFRPADGNETAGAYKIAVANRAAPSLIALSRQKVASNLTGTSMDAVKQGGYTISDNSGEQMPEIILIGTGSELCLCEGSARRLREAGRRVRVVSLVCWRLFDGQPREYKERVLPSNVVKRVSVEAGSPVGWREYVGREGVVVGVDEFGASGHYLDTFNKYGFTEENITRIADILLCK
51
Q9LYT5
3.1.1.11
ACT_SITE 355; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 376; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"
MATTSFSLPNHKFGIKLMLFLVLNLLSLQTSVFAHSSNSKFTKISRHPNSDSSSRTKPSTSSNKGFLSSVQLSLDHALFARSLAFNLTLSHRTSQTLMLDPVNDCLELLDDTLDMLYRIVVIKRKDHVNDDVHTWLSAALTNQETCKQSLSEKSSFNKEGIAIDSFARNLTGLLTNSLDMFVSDKQKSSSSSNLTGGRKLLSDHDFPTWVSSSDRKLLEASVEELRPHAVVAADGSGTHMSVAEALASLEKGSGRSVIHLTAGTYKENLNIPSKQKNVMLVGDGKGKTVIVGSRSNRGGWNTYQSATVAAMGDGFIARDITFVNSAGPNSEQAVALRVGSDRSVVYRCSIDGYQDSLYTLSKRQFYRETDITGTVDFIFGNSAVVFQSCNLVSRKGSSDQNYVTAQGRSDPNQNTGISIHNCRITGSTKTYLGRPWKQYSRTVVMQSFIDGSIHPSGWSPWSSNFALKTLYYGEFGNSGPGSSVSGRVSWAGYHPALTLTEAQGFTVSGFIDGNSWLPSTGVVFDSGLL
125
W5MG69
3.4.21.92
ACT_SITE 140; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 165; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
VVFRAANVCALDISPVNRLLHGGVSLLRGCRLMHHSAPCRSPLIPIVVEQTGQGRGERAYDIYSRLLRERIICVMGPIDDSVASLVIAQLLFLQSEGNNKPIHMYINSPGGVVTAGLAIYDTMQYILNPISTWCVGQAASMGSLLLAAGTSGMRHSLPNARIMVHQPSGGARGQATDIAIQAEEILKLKRQINTIYSKHTGQALDIIESVMERDRYMSPIEAQDFGIIDRVLVHPPQAGEDEPAVLQKEPTPSSAPCTPTEPSTNPQPPQGTPASSAKPEP
179
A0A3B6RMS7
3.2.1.1
ACT_SITE 229; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 254; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MGKKNTHLCCFSLPLLLFAGLASGHQVLFQGFNWESWKQSGGWYNMMMGKVDDIAAAGVTHVAPAAVALCRQRRSSSGLPLPLPTKSFVPQHVRLFWFCYMPGRLYDIDASKYGNEADLKSLIGALHGKGVQAIADIVINHRCADYKDSSRGIYCIYEGGTSDGRLDWGPHMICRDDTTYSDGTANLDTGADFDHAPDIDHLNERVQRELKEWLLWLKSDLGFDAWRLDFAKGYSPEMAKVYIDGTSPSLAVAELWGDMVPGGDGKPNYDQDAHRQNLVNWVDKVGGAASAGMVFDFTTKGILNAAVEGELWRLIDPQGKAPGVMGWWPAKAVTFVDNHDTGSTQAKWPFPYDKVMQGYAYILTHPAIPCIFYDHFFNLGFQDEIAALVAIRKHNGITATSALKILMHEGDAYVAKIDGKVVVKIGSRYDVGAVIPAGFVTSAHGNNYAVWEKTGAAATLQRS
157
Q12674
7.6.2.1
ACT_SITE 566; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000305"
MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGENSECFVETMALDGETNLKSKQPHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKNHRNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQRKINMIIVFMVFVVATISLFSYLGHVLHKKKYIDQNKAWYLFQADAGVAPTIMSFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSDKTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDNFEDNRDNTNSLRLPPKAHNGSSIDVVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLFGKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYPTALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDGEAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAKKMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSLHKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIERTLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGLNLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVILTTTDENIISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVICCRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWSLSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATTNSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSVVLSCGGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVYKTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLSRPRTNSRASAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPSLKTQSSKDSIGGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE
259
A0A9J7KSV9
6.3.4.4
ACT_SITE 48; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 76; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 176; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
MAENRGNIAPPRTANGDHSDPTEDGPLEKRLRYHGNKVTVVLGAQWGDEGKGKVVDMLGTDADVVCRCQGGNNAGHTVVVEGTEYDFHLLPSGIINDKAISVIGNGVVIHLPGLFEEAGKNEAKGLIDWQDRLIISDRAHLVFDFHQAVDGLQELEKGGKSLGTTKKGIGPTYSSKAARSGLRVCDLLADFKVFSDRFKMLVTQYERMFPNLKVDVDKELKRYEDLKERVRPMVKDVVHFLNTQLEGPQKKLLVEGANATMLDIDFGTYPYVTSSNCTVGGVLTGLGIPPRCIGEVYGVAKAYTTRVGDGAFPTELNNELGELLQERGHEFGVTTKRKRRCGWLDLVLLKYADMINGFTAIALTKLDILDVFDELKIGVAYKLDGKKLPNFPANQEMLKQVEVEYCTMPGWKTNTENLRSFHDLPENAQKYVRKIEEVLGVPVRWIGVGAARDSIIKMF
253
A0A8I5ZR79
3.2.1.23
ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 269; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
MFRVPLCMLLPLLALLQLLGAAHSFYNVSQRTFELDYKRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLDAIQTYVPWNFHEPQPGQYDFSGDRDVEHFIQLAHQLGLLVILRPGPYICAEWDMGGLPAWLLEKESIVLRSSDPDYLAAVDKWLAVLLPKMKRLLYQNGGPIITVQVENEYGSYFACDYNYLRFLEHRFRYHLGNDIILFTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQRNFEPKGPLINSEFYTGWLDHWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNGANMPYAPQPTSYDYDAPLSEAGDLTEKYFAVRDVIRKFKEVPEGPIPPSTPKFAYGKVALRKFKTVTEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPINGVRDRAYVSVDGGLISNMTLNFTVLTNWTMFPLDTEALARSHLGNWEAADEGHLDGHSTLRSSNFTLPTFYVGNFSIPSGIPDLPQDTFIQFPGWAKGQVWINGFNLGRYWPTKGPQMTLFVPRNILTTSAPNNITVLELESSPCSNGTLELCTVEFVDTPVIG
163
P38590
3.1.3.48
ACT_SITE 319; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPLMEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASIYTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLKLKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNIDMVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNSPGEEGETVHMPEEDDIGNNEVSSTTKSYSSASFRSFPMVTNLSSSPNDSSVNSSEVTPRTPATLTGARTALATERGEDDEHCKSLSQPADSLEASVDNESISTAPEQMMFLP
149
O77263
2.1.1.33
ACT_SITE 160; /evidence="ECO:0000255|HAMAP-Rule:MF_03055"
MVATGGQAQDQGQNQEPDVLNPTSAVTGLPQKRYYRQRAHSNPIADHSFDYPARPEDVDWRSMYPGIQQGQQVSFADIGCGYGGFLVTLGEMFPEKLSIGMEIRVKVSDYVVDRIAALRRRCADTGAYQNIACLRTNAMKYLPNYFVKGQLEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYILRKGGLLYTMTDVEDLHKWIVTHMEEHPLYERLTEEEANADPITPKLYQSSEEGAKVVRNKGDHFLAIFRRL
45
A0A078IUE2
2.7.11.1
ACT_SITE 309; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 326; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MEEVIAEPPPTISPAIVDYDEHIEDDDDDSDLSISSDSDIGEALDWLDGKDDDELIGGGFSLHARRPNAHGGNGARPNSGALQPLSNKAQKLSSHVRASPLEAWEGRVEVGMSNSVTTAIRGSLRDTEIGRSRNTDKADRATVEQALDPRTRMVLFRMLNRGVFNDVNGCISTGKEANVYHATKSDGAELAIKVYKTSVLVFKDRDRYVQGDYRFRHGYCKHNPRKMVKTWAEKEHRNLKRLQAAGIRCPVPILLRLHVLVMEFIGRDGWAAPRLKDAALSLDKLRESYLELIIQMRTLYQKCKLVHGDLSEYNILYFEGHLYIIDVSQSVDLDHPLALTFLREDCDHVSDFFKKHGVAVMTIRELFDFIVDPTISDENVDSYLEEVQRKVIERGELSVEDEIADSVFMKSYIPKSLDAVKNPEADVEKITSGQDTGDMLYQTITGLKDALPKVDEQQVKVDVEDKIEEGGGEKEEESENEEEESESESESEEELGPEDKKAARKEHKKKVKEEKREARKNKTPKSVKKRKKKISKPHKTR
99
A0A2R6W9D6
1.11.1.7
ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKTFSLLATCILFAAVAAPARAQLSVTFYNSTCPSGVSKVGEVVRSWITSDRTLAPSLLRLHFHDCFVRGCDASVLLDVANGEKSAFGNANSLRGFEVIDDVKAKVEALCPGVMSCADILSLAARDAMVEFGAAGLNWTVPLGRRDGVVSSAAEANSNLPPPFATFQQLVTSFSNKGFTTREMVVLSGSHTVGATRCSTIQGRLYNFSSTAPTDPALDANFAASLKTQCQFGDTTTKILMDQSTPVDIWNKNYYANVINGKVMFQSDDALKRVAAGKTFVQIMRAANSPFTPEFAAAMTKLSQVGVLTGTSGQIRTNCRAVV
14
Q9X8R6
4.1.2.13
ACT_SITE 95; /note="Proton donor"; /evidence="ECO:0000250"
MPIATPEVYNEMLDRAKAGKFAYPAINVTSSQTLHAALRGFAEAESDGIVQISTGGAEFLGGQHNKDMVTGAVALAEFAHIVAEKYDVTVALHTDHCPKDKLDGYVRPLIAVSEERVKAGRNPLFQSHMWDGSAETLADNLSIAQELLARARAARIILEVEITPTGGEEDGVSHEINDSLYTTVDDAVRTVEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKELNEGIASKYGQPAGSKPFDFVFHGGSGSTAEEIATALENGVVKMNIDTDTQYAFTRPVVDHMFRNYDGVLKVDGEVGNKKTYDPRTWGKLAEAGMAARVVEACGHLRSAGQKIK
197
A0A2C9VC76
2.3.2.26
ACT_SITE 1539; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MGNRGQKRVEMMDELPADKRACNNSLEFRPSSSNSSIQTQINSTNSTSETNDADMDTSSTGSASSRSEEEEHERDSAYGSCDSDDAVPKHGSLRIYQRQRSFGDHGRLRTALSNLSEGTEPSGQIAALTELCEVLSFCSEDSLSSMMADSLSPVLVQLARHESNPDIMLLAIRALTYLCDVFPRASGFLVRHDAVAVLCQRLMAIEYLDVAEQCLQALEKMSREQPLACLQAGAIMAVLGFIDFLSTSVQRVALSTVVNICKKLPTDCPTSFMEAVPILCNLLQYEDQQLVENVVICLMKIAERVSHSSEMLDELCKHGIINQATHLIHLNSRTTLSQPIYNGLIGLLVRLSSGSVVAFRTLYELNISCTLKDILANYDISHGISSLHAVDGQSNQVHEVLKLLNELLPPVVKDQDIQQVVSDKELFLVNHPDLLHKFGSDILPMLIQVVNSGANLYVCYGCVSVIQKLIYFSKSDMLVELLENASIPSFLAGVFTRKDHHVLILALQIAEIILQRLSGVFLNPFIKEGVFFAIDALMLPEKCAWSMFPVFNGIQLPSDSSQKSVSKVVLRCLCYAFDNGQSPITSEAGTCKLEKDSVQSLAKHIKTTYFAPQLCNSENGLTDILQNLRALSASVTDLINMPISFNTSTQDEENFNRLLHQFMAKLNGREPVSTFEFIESGIVKSLVNYISSGQYLREKVNLHSASFDYYVIEKRFEVLARLFSPYSSFAEELPVSLLVRKLQSALSSLENFPVILSHSSKQRNWFAAVPNGRCMPHPCLRVRFVRGEGEMCLSDYSNDAVTVDPFSSLDSIEGFLLPKVRIERTKQIETAALAMDPMESVQLQSNVNPGAGRGESSDHMEPDSTSTDLTEIQENEAKLSVSRLEETENLQQGNPGETTSSNDSHLGSLEKLVQYPSGADITRKSHHSSSSSNSDAFSKLLFYLEGKELDRTLTLYQAILQQKIKADEEITMGTKLWSQVYELTYRTAVEPKDDNPQEFHMSARDSSTLDKVGAYMQHTSFFTSIFNCDLASDLDKSSPTYDVLFLLKSLEGLNRFTLHLMYSERIRSFAEGLVDNLDNLKVVVHSVPQNEFVSSKLTEKLEQQMRDSLALSVGGMPLWCNQLMASCPFLFSFEARCKYFRLSAFGTQLVQPQTLSNNNSEVSRDRRSSPGSLVRKKFVVWRDRILESAAQMMDFYANVRDPIEVVYNGEVGSGLGPTLEFYTLVSHEFQKSGLGMWREDYSSFVDRKIFQTEDSGSLTSPFGLFPRPWPSSLDSSDEIQFSEVIKKFFLLGQVVAKALQDGRVLDLPFSKAFYKLILQQELNLYDIQSFDPELGRTLLEFQALVNRRKFLKSALEENSCNTLEVCFRNSRIEDLSLDFTLPGYPDYMLHQEHEMVNMDNLEEYVSLVVDATVYAGISRQVEAFKSGFNKVFPIKYLQIFTEEELDRLLCGEHDIWAFNELLDHIKFDHGYAASSPPIINLLEIMQEFNQEQRRAFLQFVTGAPRLPPGGLASLSPKLTIVRKHCSNCVDADLPSVMTCANYLKLPPYSSKDKMREKLLYAITEGQGSFHLS
65
K3ZDQ6
3.2.1.52
ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MEPALRLLLVLMVFMPCTGDVNVWPMPKSVSNGKQTVFISKDLKMTVVGSNYSDEKAILRDAFGRMVAVVEQDHVISESYERSPVLVGMNVVVRSRDDELNFGVDESYSLFVPSTGHPLYAQIEAQTVFGALHALETFSQLCSFDLESRQIILRSAPWSILDSPRFPYRGLLIDTSRHYLPVPVIKRVIDSMTYSKLNVLHWHVVDEQSFPIEIPSYPKLWNGAYSYSERYTKDDAIDIVQYAEKRGVNVLAEIDVPGHALSWGVGYPSLWPSAICKEPLDVSNNFTFEVIDGILQDFSKIFKFKFIHLGGDEVNTSCWTTTPRIKEWLILNGMDETDAYRYFVLRAQKIARSYGYDIINWEEPFNNFGDKLDRNTVVHNWLGGTVAEKAVAAGLRCILSKQESWYLDHLDAPWEGFYMNEPLANIYKPEQQRLILGGEVCMWGEQVDASDIQQTIWPRAAAAAERLWTPIEKIATNTSMVAPRLARFRCLLNQRGVAAAPLVGYGRSAPSDPGSCISQ
170
Q9VQ00
2.3.2.23
ACT_SITE 105; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
MEGLFSAEDGTPSCSWTCSNSAVKRIQKELDEITRDPPQYCSAGPKEDNLYEWTSTIIGPADSVYENGIFKLDIFFPVEYPFAPPVVIFRTPIYHCNIHRLGFICLDILKEKWSPALTISKILLSICSLLTDCNPKDPLMAKIGTEYLKNRAEHDKKARLWTKRYAKDE
64
A0A067FVF9
1.11.1.7
ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAFRVAFLTSLLILSMSSSGNALSLNYYEKTCPDAEWIIAAAVKAAAAKDKTVPAALLRMHFHDCFIRGCDASVLLNSKGSNKAEKDGPPNVSLHAFYVIDNAKKQVETLCPGVVSCADILALAARDAVVLSGGPTWDVPKGRKDGRTSKASETVQLPAPTFNISQLQQSFSQRGLSMEDLAALSGGHTLGFAHCSSFQSRINTNNADPTINPSFAESLRNICPIHNQAKNAGANMDASSATFDNTYYKLILQGKSLFASDQALLSHPETKNLVSKFASSHQSFNEAFVKSMIKMSSINGGQEVRKDCRVVN
14
A9V986
2.3.1.48
ACT_SITE 206; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MKRRYNEVNNLPTNEDVDATTAALELEHEKHTKVKFVNRIYFGVYAMDTWYFSPYPDEYGKSPALFVCEWCLKYMLQPTSLRDHDCQHRQPPGREIYRKGNVSVYEVDGAEHKLYCQNLCLLAKVFLDHKTLYFDVSTFLFYILTEVDADGAHFVGYFSKEKVSVDNNNLACICTLPPYQKKGYGRFLIEFSYALSQAEGKIGSPEKPLSDLGKLGYRSYWSWLLLNALRGKKGTISMPALSKATGIAPDDVFNTLQALNLTKYWKGEHVVCITPKLIDDLLATGKFKGPKVPVDVRCLRWSSPL
61
B0G133
1.11.1.24
ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MGIMKIGEIAPEFTLPNKDGKLFNLKDFAGKPLVIFFYPNNIGWVCTREVCYFRDSYEKFIEMGAEVPGNSPNTMDNHKKFHAAHRVNYTILSDKNGAIGKLYGVNGLLPGRVTFVIDKNGKIALNHHTSWLSHSSHIENSLSVIELLNSQ
12
A0A0A0MQ23
3.2.1.52
ACT_SITE 340; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
AAPALDLGRPAMRHRGLGLAALLALLAALAPRSSAAPEPALWPMPLSVKTSPRLLHLSRDNFSIGYGPSSTAGPTCSLLQEAFRRYHEYIFGFDKRQRRPAKPNSAIELQQLLVTVVLDSECDLFPNITSDESYTLLVKEPVAFLKANRVWGVLRGLETFSQLIYQDSYGTFTVNESDIIDSPRFPHRGILIDTARHFLPVKSILKTLDAMAFNKFNVLHWHIVDDQSFPYQSVTFPELSNKGSYSLSHVYTPNDVHTVIEYARLRGIRVIPEFDSPGHTQSWGKGQKDLLTPCYNEHKQSGTFGPINPILNSTYNFLSQFFKEVSMVFPDHFVHLGGDEVEFQCWESNPEIQGFMKQKGFGKDFRRLESFYLQKLLGIVSTVKKGSIVWQEVFDDHVKLLPGTIVQVWKNQVYTEELREVTAAGFPVILSAPWYLDWISYGQDWRNYYKVDPLHFDGSQEQKKLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPEDITSVGNAYNRLTVHRCRMVRRGISAEPLFTGYCDYEYKT
170
Q8RIA2
5.1.3.3
ACT_SITE 172; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 298; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MRYFFNSYGGKLEEIKVYTLENEFLKVEFLNLGAIIKKIELKNKNGDVKNVVLGYENIEKYRENPAYLGAIIGRTAGRIKDGILKIDDIKYQLDKNNNGNTLHGGKKSISHRFWNVGKIENGLCFSIKSFHLDNGYPANIEIKVSYILNNNELLIKYFATTDNLTYLNLTNHGYFNLNGNPNKPIYEDILKIDSDYLIGIDKNSIPCKTINLDNNIFDFRESKKLEEFFKADDEQKTLANNGIDHPYIFNKEIGKLEIKNLESGIKISVETDNPAVVIYTANYLQDIGFKKHSAICFETQEAPNLYRDEDINIYPTFIDKNTNYGKYTKFIFEIN
211
Q8BLK9
2.7.11.1
ACT_SITE 919; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MTSPWGHSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAYPDSPANAFPECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRTFGLSLSTDSSAVGAVASDSEPSRVEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRAAPQLHTGPQPPGSLSSRPPWSLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQRAEGGKLWSYISKFLNRSSQESLDIKEGRPSMPPRVCLQQPSASPQGGSSFESRGSDTGSMLKALPLKTSLTPSSQDDSNQEDDGQPSSPKWLDSGSSSEDECTAGYLTLCNEYGQEKMDLVSLSEESVMQPEGDKADTQAVSSPASLATGSVSPSTHLRVFSGGEDLEAVSSPPTSESLSRSKNSPMEFFRIDSKDSTSELLGLDFGEKLHSLKPEPLKALFTLEDGDSPSQSLDPGESKRESEAQDSVSRGSDDSVPVISFKEAAAEAISGAEEGRPDLLVNLPGELQPTKEASAMDPKFSQASAGRLDSKLLEAPDVLCLRLSSEQCHGLGPEGPEELSDPTEFCPGGVIPEHDAQADPGVLFEAAVDHRSSPDQFLFSSLRSESDRLGQVEVVVTAQALQESLFHISSPCSGANKEHSAYADTATSEEVLLFTEPTKEEANSLFQRGSEAQERGVGAGEADKEIHQIFEDLDKRLAASSRFFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDSCDSDAVARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR
99
Q55FN5
3.5.1.98
ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000250"
MSTRKVSYFYDNEVGNHYYGPNHPMKPHRMRMTHDLVLNYGIYKKMQIFRPRKASELELTNFHSDDYINFLKLVTPDNMHDYSKQLVKFNVREDCPVFDGMYNFCQISSGGSIGCAVKVNSKESDVAINWAGGLHHAKKSEASGFCYTNDIVLSILELLKHHERVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGDYFPGTGDVKDIGADKGKYYSLNFPLKDGIDDESYQSIFRPIIRSVMDFYRPGAVVIQCGADSLTGDRLGCFNLTLRGHAQCIEFLKSFNVPLVVLGGGGYTIKNVARCWTYETSILVDSELKDELPYNDYLEYYGPEYRLHITPNNMENQNTKDYLEKLKIQLLENLRNLNHAPAAAHHDIPPDSFNYSDDEDDEDPDVRISEADRDKKVHHQGELSDSDEEDGRRNYSNGLEATSTSRRNQVSISAYDKERPSYNSRNNNNNNNNNNNNNNNNNNNSNNNNSHHHNEDADVDMDSG
184
P0CP66
2.7.11.24
ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTIDQSQINFNVPSTYKLEEIVGEGAYGLVVAGTHLPSGTQVAIKRITPFDHTMFCQRTLREIKLLRHFHHENIISILDLIQPESYEVFNEVYLVQELMETDLHRVIRSQELSDDHCQYFVYQTLRGLKALHSADVLHRDLKPSNLLLNANCDLKICDFGLARSSAKPPPGTSDGGQGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWSVGCILAEMINGKPLFPGRDYHHQLSLILQVLGTPTMDDFNEITSQRSKDYLRALEFTRRQDFSAICPKAKPAAVDLLKQTLTFSPSKRITVEEALMHSYVEAYHDPHDEPNAEPLKPGFFDFEFHQEKLSRDQWKRMIYDEVQDPVPTILSQWTESH
104
Q7AKQ5
3.4.25.1
ACT_SITE 54; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113"
MEANTRSTGRLPAAFLTPGSSSFMDFLGEHQPEMLPGNRQLPPVQGVIEAPHGTTIVAVTFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGAQLSLEGKANRLSTMIRSNLGMAMQGLAVVPLFAGYDVDRGRGRIFSYDVTGGRSEERHFATTGSGSVFARGAMKKLFRDDLTEEQATTLVVQALYDAADDDSATGGPDVARRIYPIITVITEDGFRRLGEDEAAELAGSVLQARLEQPDGPRAALL
180
A0A0G2JY48
2.7.10.1
ACT_SITE 725; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
QMTSTLGCPLLTPSSWLDSGPELAKDWETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCPRVIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAVNRVVALFNHLLCSQQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEVASRGCPPSLPMAYCGSHLPGCLQVAPALCSCSRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFTNAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV
97
A0A1Y1HZA7
3.1.3.48
ACT_SITE 115; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50"
MDEAKLGRSPPYAMKLVRPGLYIGNAADAADEETLRKVSITHILCLAPTLSRASSALAALFGPPRSGQSSPAAPPFRRLELSVKDDEDQNLLDHLPECIDFIEEGRAKGGVLVHCVAGISRSGSVVTAYLMYKEGLSAKDALASLRQASPSACPNDGFLEQLSIFESMGNRIDERNTAYKMFRLTSLGRAWRGGEPVSPKFADDPNIGSRRSSANNLLEEGEDQLGGLPGDKKVVCYRCRKCRRAVAGVENVLPHDKGGGQSAFDWKKRSKSLDSGAIDDECSSYFVEPMQWMNSVHEGELEGKILCSKCQSRLGSFNWSGTQCSCGAWITPAFQLNKSKVDESWT
149
Q8C050
2.7.11.1
ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 608; /note="Proton acceptor"; /evidence="ECO:0000250"
MEGEGGGSGGAGTSGDSGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKIKWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSERLFQGYSFVAPSILFKRNAAVIDPLQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQVAASAQPPGQVVLCSLLLLALLFNRSLTRKPVTWTWLVHSTSQLPPLPPPMPEIVLFILLSDNGQLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKRTSTSTETRSSSSESSRSSSSQSHGKTTPTKTLQPSNPTEGSNPDTLFQFSD
99
U5D3K6
3.2.1.143
ACT_SITE 314; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 332; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 333; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
MEERGDLRSVLPLLPLVMRDSSHSWPRRVLEALKAKSTGPELSLSRPRRVLEALKAKSTGPELSLSWPRRVLEALKAMSRGPEFSGLSNGHVLFDAIADLRKQLGFSDDNLATDSGHGYSLFFDDLMSGEESIKWFGETLPSMACLLMHLPSLLEAHYRDCDKSREIEERGLPIGTGLRVLESQEAGMVVLSQELIGALLACSFFCLFPSIGRSFRNLPTINFDYLFVSIHNSYSPSQKHKIKCLVHYFERICSCMPMGFVSFERKVLPLNGSSLHISYPKTDFWSKSIVELCPFKVLHSGVIEDQPYEALEVDFANQYFGGGALHRGCVQEEIRFMINPELIVGMLFAPRMEDNEALEIVGAERFCNYRGYASTFVFSGNYVDHKPLDIRGRRRTRIVAIDALCHPGIQQYGADCLLRETNKAFCGFMDHSKCHQYMNIFKEGKLQDLDNGAHAAISKTEDDSGIKARNCSDREAEATACSTSTTAMNRSTQVTDLFEEAKLKNDQGLNCCENVGIATGNWGCGAFGGDHELKSMIQWLAASQALRPFLVYYTVGDKATKRLEQVQEWISSHYWTVGDLWNMMVEYSSQRYQGTTNIGFFDWLLPCL
159
F7ASA8
2.7.11.1
ACT_SITE 343; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MRTGRGAERRDIDWSGRFWAPPSFLFSTSVAIFVPGMPVLVVSLFNALGSSLQQPWGRPGANISPFIFHQQSQCWGLTGDLESQCNMDISKENSVSGPSNKTAILLGEGPKRVPITQQISSQSRLPGSSGQAQRVLCSSNPLLVSSQAQKNISSHKTSHAHQSQKLQQAPVIHPTSRPPSSTQNTEQSQPPVSASIPGKGETPRQKNEETKKRQWALDDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYRELQKLSKFDEQRTATYITELADALSYCHSKKVIHRDIKPENLLLGSDGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAETYQETYRSISKVEYKFPDFVTEGARDLISRLLKHNPYQRLTLKELLEHPWIIANSSKSPSSRKSKESKP
99
M5WGJ8
1.11.1.7
ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGIPKLLGVFLVMEMMSGFRFGAHGLSMGYYVMSCPMAELIVRNSVIRALQADPTLAAGLIRMHFHDCFIEGCDASILLDSTKDNTAEKDSPANLSLRGYEVIDAAKEELEKECPGVVSCADIVAMASTYAVFEAGGPVYDIPKGRKDGSRSKIQDTINLPPPTLNASQLIKMFGQHGFTAQEMVALSGAHTLGVARCSSFKNRLVDAVDPNLDSGFAKQLTKTCSAGDNTEQPFDGTRNHFDNLYFNALQHNTGLLASDQTLFSSARTRNIVNGYAFNQAMFFFDFQQAMVKMSMLDVKEGFKGEVRQNCRKIN
14
A0A7M7NZ19
1.2.1.12
ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1"
MVIQVGINGFGRIGRLTLRAALENSEVQVVAVNDPFIDLEYMVYMFKYDSTHGQFKGDVKCESGNLIVNGKKIKVFQQMNPSEIPWGENGAEYVVESTGVFTTIDKASAHMRGGAKKVVISAPSADAPMFVMGVNEDKYEAASMNIVSNASCTTNCLAPLAKVINDNFGIEEGLMTTIHAYTATQKTVDGPSAKKWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPVPDVSVVDLTVRLKKPASYDTIKKTVKAASESKALGRYLGYTEDQVVSQDFRGDMHSSIFDAGAGIALNDNFVKLVTWYDNEYGYSFRVIDLILFMASKSS
22
H2N0T0
2.7.10.1
ACT_SITE 765; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MSCGAQRARAPPLRSPSQSAARAGAGKLFQMDFPLGNWLFFSLCLLITRTVITLQSNEVVLLDMRKVGGELGWLTLPLKEPGWEVTQRTLNGSQFYTYSVCNVEEREQDNWLRTTFIQRGASVSRVFVEIQFLVRDCNSFDGGSLTCKETFNLFMSESDADVGMTFRKGQFKKVATVAPDKISGKGEMNINTETKVVESLSRKGFYLAFQDIGACVALLSVRVYYKICPEKVMELALFPETVASPGLRKVNGKCVDHAVAAELPHSHCSADGDWVVQVGRCLCQAGYEKVKDSCQGCQPGFFKAEASNRSCEACPANSQALVSGAQFCFCKDGFYRAPTDLRTGPCTGLPSAPRDLMASTQLPSGKLLLSWKPPEDTGDREDITYNVECQRCDGPVCQTCGEKIRYEPGSVGLTDTKVLVSQLDAHLNYTFTVEALSGVSQVLEEEMPSSTSITTSVLFTDPPKPISIQLVEQTPTSLSLSWDVSPRSQPTSYELTYRKKDDNLDKTTYIWLKLEKNYAQIKDLAPATAYLFRVQALSSDGSHGGFSQEEQFETLSEEHHSKTAVILAAAAGGASMLILVLVVLFVRRRRRNSHRQRQDDTYFSTPEQLKPLKTYVDPHTYEDPNVAVLKFATEIPPSHVTKQKVIGAGEFGEVYKGILKAPGKKEFAVAIKTLKSGYSEKQRQDFLSEASIMGQFSHQNIIRLEGVVTKFKHAMIVTEYVENGALDKYLRNHDGEFSSFQLVGMLRGIAAGMKYLSDMSYVHRDLAARNILVNNNLECKVSDFGLSRVLEDDPEGTYTTSGGKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLPAPMDCPSTVYQLMLQCWLQDRSKRPRFGDIVSLLDKLVRSPDSLKTIADFDPRISIRLPSTSGSDGSPFRSVSEWLESIKMNQYIDNFTSAGILTMDQVLQMKNEDVKNIGVRLPGHLKRIAYSILGLKDQTSTLSVFAV
97
W1PK41
1.11.1.7
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGLSIEMQLLLVLSLSLIPNFEAQLEVGFYSQRCSPAERIVKDAVRSAVSNDVGLAADLIHMYFHDCFVRGCDGSILIDSNSTNTAEKDFFANKISLRSFGVLDSAKSKLEDMCKGVVSCADILAFAARDAAEMVGGIGWDVPAGRRDGRISLASENLANLPAPTFTVPQLTQLFLSKGLTQEEMVTLSGAHTIGRSHCTSFSNRLFNFSSTSSQDPSLDPRYATQLKSKCPKGNTNTNLVVPMDPLSPTVLDNAYYKNILANRGLFTSDHALLSDPSTSSQVSEYAANVFLWRTKFGAAMVRMGQIGVLTGNAGEIRRNCRAVN
14
A0A1U8JW26
1.1.1.100
ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1"
MAVAASSVIALNSVSIFGDSSDRKFLPTRQWSPISCRIGSVHTKPCIGLQCRSRSFTSSSVRAKRVEQASSEAAQEVEAPVAIVTGASRGIGKAVALALGKAGCKVLVNYVRSSKEAEAVSKEIESYGGQAVTFGGDVLKEANVDAMIKTALDAWGTVDILVNNAGITRDTLLMRMTKLQWQEVIDVNLTGAFLCTQAAAKVMMKKRKGKIINISSVAGLVGNLGQANYSAAKAGVIGLTKTVAREYASRNINVNAVAPGFIATDMTSKLGGDIEKRILTTIPFGRYGQPAEVAGLVEFLALNPASNYITGQVFTIDGGMVM
2
Q8EH82
3.4.21.89
ACT_SITE 90; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 145; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MAAYFSIILVLVTLISGLIWLVDVLVFAPKRAARLLLAKESNASLTEEAEYSIMRESTIVETAHSIFPVIAFVLILRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGLKDPVWRTKLIETGEPKRGDVIVFKYPENPQIDYIKRVVGLPGDRIIYRNKQLMIQKACGVEQTQCPEPELVARTEVSRGDFSQDGVPLLRYKEQLGEVAHDILINPSRPDMLGYFKRDGDLPAGEFLVPEGHYFAMGDNRDNSTDSRFWGVVPEENLVGKAVAIWISFEFDRTKADFLPTWLPSGIRFERVGGIH
178