Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
P9WIS7 | 2.3.1.12 | ACT_SITE 523; /evidence="ECO:0000250"; ACT_SITE 527; /evidence="ECO:0000250" | MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQK... | 54 |
Q92QM8 | 2.7.7.7 | ACT_SITE 143; /evidence="ECO:0000250" | MIDSAAPPSGFCRDCLKEQAAHSRRCLACGSPRLLRHSELYRLTLAHIDCDAFYASVEKRDNPELADKPVIIGGGKRGVVSTACYIARIHGVRSAMPMFKALEACPQAVVIKPDMEKYVRVGREVRAMMQELTPLVQPLSIDEAFLDLSGTERLHHDPPARTLARFAKRVEQEIGITVSVGLSYCKFLAKVASDLQKPRGFSVIGQAEAADFLKAKPVTLIWGVGKAFAATLERDGIRAIGQLQTMEEADLMRRYGTMGRRLYRLSRGLDERSVEIDGEAKSVSSETTFNDDLARQEDLVAHLRGLSEQVAFRLRKSALA... | 121 |
A0A9R1UR99 | 2.4.1.18 | ACT_SITE 426; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 481; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MYCSLVTLPRAADLGFLTQFYSKNSSMATRSNFYIAPSQLTKLSVGPRNQKVSSRLPHKPRLSSTPTRANHDSAVVTDELSPMTNIKAEMKTPKILELDPALGPYKDHFEYRMKRFSEQKLLIDQYEGSVEEFAKGYLKFGLNREDGSIVYREWAPAAEEAQLVGDFNDWDGSNHKMERNEFGVWSIKIPDHDGNSSIPHNSKVKFRFKHNNGVWVDRIPAWIKYATVDSTRFAAPYDGVHWDPPPSERYEFKYPRPPKPNAPRIYEAHVGMSDSEPRVNSYREFADNVLPRIQANNYNTVQLMAIMEHSYYGSFGYHVT... | 73 |
Q6CAC0 | 3.2.2.27 | ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MKITDAFQKAPILATTTKTVANASFDQSAWLNGLKPADKELLDTEITHIHDSWLPHLHKEISKPQFLNLKKFLASREAAGVNIFPPKKDIYSWTSLTPFDKVKVIIIGQDPYHGKNQAHGLAFSVNPPTLPPPSLKNMYKCLKNDYPDFDVPAKSGLLTPWAEQGVLMLNTVLTVEEKKANAHKDKGWEAVTFTALSAAVKHNSGCVILAWGSPAAKIADKMNIDKSKHLVLKAVHPSPLSAHRGFLTCGHFKQANEWLEKRYGPEGIIKWGLEGKTVGSKGTKEATTDTVKEELAKESIKESVETVKEPTEQSSVKPTS... | 173 |
P73411 | 1.1.1.49 | ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00966" | MVTLLENPFRTGLRQERTPEPLILTIFGASGDLTQRKLVPAIYQMKRERRLPPELTVVGFARRDWSHDHFREQMRKGIEEFSTGIGSEDLWNEFAQGLFYCSGNMDDPESYLKLKNFLGELDEKRNTRGNRVFYLAVSPNFFPPGIKQLGAAGMLSDPVKSRIVIEKPFGRDLSSAQSLNRVVQSVCKENQVYRIDHYLGKETVQNLMVFRFANAIFEPLWNRQFVDHVQITVAETVGVEERAGYYESAGALRDMVQNHLMQLFCLTAMDPPNAIDADSIRNEKVKVLQATRLADINNLENAGIRGQYKAGWMGGKPVPG... | 6 |
Q19192 | 2.7.11.1 | ACT_SITE 933; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSVYYIVLAGFLLFMALVPFNAGQQYIDDDIEVVSSCQNGYVQNAGCDQNSQVNIIITATLDGVVTALDGETGEMIWRYEDAPLLRGTLSTSDPIDIGGTSLQLMPTLDGRLFSYTHNTNLIEPLPITTDSLLESTIRLGQDAVAGGKSVTTKGFDLFTGEQKYECSMESCGPGDTETPKNPIILIRRTTNSIRAMDTLRGIERWNLSTAEIGVTLAGGITSPTLVSDVKILLQPPDGVIVAVDKYNREEWKTNVDGHIVSVWQVYGNQIGEISIFDPSNIFTTQYEVMQREQHNLQTQSSLLYMGTSNGFPFIIQSPKA... | 99 |
Q6UD73 | 2.7.11.1 | ACT_SITE 441; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNLKNGLLLFILFLDCVFFKVESKCVKGCDVALASYYIIPSIQLRNISNFMQSKIVLTNSFDVIMSYNRDVVFDKSGLISYTRINVPFPCECIGGEFLGHVFEYTTKEGDDYDLIANTYYASLTTVELLKKFNSYDPNHIPVKAKINVTVICSCGNSQISKDYGLFVTYPLRSDDTLAKIATKAGLDEGLIQNFNQDANFSIGSGIVFIPGRDQNGHFFPLYSRTGIAKGSAVGIAMAGIFGLLLFVIYIYAKYFQKKEEEKTKLPQTSRAFSTQDASGSAEYETSGSSGHATGSAAGLTGIMVAKSTEFTYQELAKATN... | 99 |
K7DCW7 | 1.8.1.4 | ACT_SITE 516; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MRREGRPWRSGGGAQRRWKYWRKGKYSGKMQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDV... | 36 |
O49298 | 3.1.1.11 | ACT_SITE 380; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 401; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MDHKILLTPPKSLYTKCIITIIYVVSISHLNAHFITSCKQTPYPSVCDHHMSNSPLKTLDDQTDGFTFHDLVVSSTMDQAVQLHRLVSSLKQHHSLHKHATSALFDCLELYEDTIDQLNHSRRSYGQYSSPHDRQTSLSAAIANQDTCRNGFRDFKLTSSYSKYFPVQFHRNLTKSISNSLAVTKAAAEAEAVAEKYPSTGFTKFSKQRSSAGGGSHRRLLLFSDEKFPSWFPLSDRKLLEDSKTTAKADLVVAKDGSGHYTSIQQAVNAAAKLPRRNQRLVIYVKAGVYRENVVIKKSIKNVMVIGDGIDSTIVTGNRN... | 125 |
D7TIB5 | 2.1.1.37 | ACT_SITE 443; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MAKRKGASEEAAPLQPCVVKKTKKSRAAAEASVVGAPISVNEARQKWPQRYISTFRKGSDSRTKDESIEAEDILQARRHFTEAVVDGCIYKLYDYAYVKAEDGQPDFIAKIVELFETIDREPYFTAQWFFRAEDTVIKDHAHLVDQKRVFYSDMRDDNPLDCIVSKVEIVQVAPNVDLAEKEKTIPPCDLYYDMSYSLKHLTFANLLTENSRTESDESSTISSEIGLNSTTDGINSAIGESSQVHKFQGSGMTLLDLYSGCGAMSTGLCLGASLSGLKLVTRWAVDINPHACESLKLNHPETEVRNEAAEDFLSLLKEWA... | 47 |
A0A3B3HZ30 | 2.7.11.1 | ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037568-1" | MSDSAAVSAGAERRMETRLKRLEDMLRDPRSALNLESLLDSLNALVLDLDYPALRKNKNIETFLNRYEKVVEELRDLQMKSEDFEKVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERGIMAFANSPWVVQLCCAFQDEHYLYMVMEYMPGGDLVNLTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRLGHLKLADFGTCMKMDATGMVRCDTAVGTPDYISPEVLKSQGGDGCYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPEEVEISADAKNI... | 99 |
A0A3N7F0J3 | 2.3.2.26 | ACT_SITE 525; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MQEIFPFVSELGSKLSKDLTGSVAESMGPSEAVVKDFSAFLIPLHSVISEQRGFGSPISMPLKKRAFNCPLYAKEIEQLHVIFIDLLDIMEKCLEKMQDSSNLKTNGEGELNHTGWSQYLFILKELNNIAKLYKGAEEKFWTVLRLRKASLCVLIVRYAKRTDDHQWLLQHKDVTDFDSRRHLAMMMFPELKEDYEDLHEMLIDRSQLLAESFEYIVHAESDTLHVGLFMEFKNEEATGPGVLREWFFLVTQAIFDPQNALFVACPSDRRRFYPNPASKVDPMHLDYFTFSGRVIALALMHKVQVGIVFDRVFFLQLAGM... | 65 |
A0A061ERA6 | 3.1.1.11 | ACT_SITE 428; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFKSPSHCWGIINFYISTKMNRVAIGGVSFILVVGVCIGLIASVTHKNGSNDTTEKDVLSTTSKSVAAICSPTQFKQACVDTLGSVANNESAVPKDFIQAAIHVTLQELQAALNKSGSIFGSAVSDKTVKMAKDDCDELLQYAVDELQASFSVVGDSDLHNMEQREAEIKNWLNAVISFQESCVDQIPQPQLQQQLSNCLLNASQLTSNALAIVNSISQIMSAFNLTSSLNLNLGGGNDRQLMDEPNPDHDTTYPSWVSSKDRKLLAGGNNAQLTPNAVVAKDGSGQYKTIGDALKAYPKNLQGRYVIYVKAGIYNEYIT... | 125 |
P34102 | 2.7.11.1 | ACT_SITE 621; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSFKKQTKTPTSWFPGLKKERDLSHHKERYCTQYDVIKVNAYGKRQQRTLAVSSLGVSNLNGQSCQWFVRNSDVYSIEQDPTDSHKFSLTFLHRYHFEAETPEQAKSIISEFKRLGVGSPSGGGGGGSGVSSNGSNSTATSPNTSPIRLYVSDPSNQPTSSSPPPQPPLSESVGVHRSSPMLSSSRMISQLSQSTSENNISSPTYHPQGLSGSSTSSSSASGGGGNNNNANNSTPPNLIASSASNSSLYSSSINSSGIINSSNNNSSISFNNNNNNNNSNLTTTTTTTSTFKTPTLPISQASKFNNESESMGLSPLTPNS... | 99 |
H3GAP9 | 3.5.1.98 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MANATKKRVSYFYHPEVGHFYYGPGHPMKPHRMKLAHHLVVNYDLYQKMDVFEPHWASAGEMKVFHAPDYIEFLQRVSPANQRDMTMDLANVRGLAVAGLTDETSDTDCPVFDGVFDFCQIYTGGTLDAVARLNFGLCDIAINWSGGLHHAKKAGGSGFCYVNDIVLGILELLKYHPRVLYIDIDAHHGDGVEEAFYVTDRVMTVSFHKYGDYFPGTGDVKDIGAKSGKYYAVNFPLHSGMDDDSYESIFKPVIDKVMETFCPSAVVLQCGADSLTGDRLGCFNVTTRGHGECVRFVKGFGLPMLVVGGGGYRIRNVSRA... | 184 |
A0A1L8I0B5 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 119; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MIFKVLALLLAVSSALASISPRNLWQFRNMIKCNIPTSDPYFDYNDYGCYCGIGGSGTPVDALDRCCQTHDKCYSDSKGHCNGILDSPYIELYDYTCSGTTVTCLSSNNACEKFICDCDRNAALCFSRAGYNSANKNLDKNRYC | 130 |
B8BTR4 | 2.2.1.1 | ACT_SITE 415; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MAALATAANEARGLAMDSIAAAHSGHMGLPLGCAEIGSILYGSQMQYNPKDTQWINRDRFILSAGHGSMFLYSWLNLAGFDLPMEEVKNFRQHHSMTPGHPEFPNSEHNTPGIECTTGPLGAGVSNAVGFAVSEKMAAARYNTDEHTIFDHHIYALAGDGCFQEGVSAEAAQFAAHEKLDNLIVLYDSNEVTLDKMAEYTQSEDIIKRYEAYGWETYEIDGHDLAVVEETIAAAKASNNGKPKFIKCNTIIGKGMEETEGTNAAHGEAGVPYVDKARASIGLPEEKWFVSEGTRDFFKGVQEKNTKTYDEWQATYAAWKE... | 51 |
P78574 | 1.11.1.6 | ACT_SITE 93; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 166; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MATKIAGGLHRAQEVLQNTSSKSKKLVDLERDTADAHTQQPLTTDHGVRVSNTDQWLRVTNDRRTGPSLLEDQIAREKIHRFDHERIPERVVHARGTGAFGNFKLKESIEDLTYAGVLTDTSRNTPVFVRFSTVQGSRGSADTVRDVRGFAVKFYTDEGNWDIVGNNIPVFFIQDAVKFPDFVHAVKPEPHNEVPQAQTAHNNFWDFVYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFALVNKEGKRHFVKFHWIPHLGVHSLVWDEALKLGGQDPDFHRKDLMEAIDNKAYPKWDFAIQVIPEEKQDDFEFDILD... | 13 |
Q6GNZ7 | 2.7.11.13 | ACT_SITE 472; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MRFNGSLKLKIGEAVELQPTRWSMRHSVFKKGSYLLDPYITINVDECRIGQTSIKHRTNKPTYNEEFCVTVSEGSKVELAVFHETPIGYDDFVAHCTLSFEELIKGCATTDSFEGWVNLEPEGKLFVVITLIGTFTEGTMRDGRLIKHFTRKRQRAMRRRVHQVNGHKFMATYLKQPTYCSHCKDFIWGVFGKQGYQCQVCTCVVHKRCHQLIVTACTCKSNACKVEKQIFEQRFGINLPHKFRYHNYKVPTFCDHCGSLLWGLVKQGLQCKMCKMNVHKRCEANVAHNCGVNSVELANALAGMGLHPGNIPFKQHSVSG... | 100 |
A0A9R1XB28 | 2.3.1.286 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSLGYAEKLSYIEDVGNVGMTEIFDPPRILQEKIERLTMMIRKSKHLVVFTGAGISTSCGIPDFRGPTGIWTLQRGGNALPEASLPFHRAMPSMTHMALVELERAGILKFVISQNIDGLHLRSGIPREKLSELHGNSFMERCSCCGMEYFRDFEVESVGLKETSRRCSNADCDVKLKDTVLDWEVDALPFEEMNPAEAHCEKADVVLCLGTSLQITPACNLPLKCLRGGGKVVIVNLQKTPKDKKASLVIHGFVDKVIGGIMELLNLRIRPFVRVDLLQTIFTQALSSDERYVNWTLRLASVHDKRAVLPFIKSVEVSFL... | 58 |
E9GU99 | 2.7.11.23 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MHVSREREPRLQRYEKIEFLGEGQFATVYKAKDTQNDNKIVAVKKIKLGSREEARDGINRTALREIKLLQELKHDHIIGLLDVFGHRSNVSLVFDFMDTDLEQIIKDTSIILTPAHIKAYILMTLQGLEYLHLLFILHRDLKPNNLLVDRQGILKLGDFGLAKSFASPTRIYTHQVVTRWYRCPELLFGARMYGTGVDVWAVGCIMAELLLRLPFLPGESDLDQLTRIFTTLGTPNEENWPGLLSLPDFVQFKAFPVIPMRHIFTAAGDDLLQLLSRFLALHPLDRCTCSEALQMPYFSNKPAPAPGSSLPLPASLSQAA... | 103 |
A0A2R6X6Z9 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATRSSSSVLVFVGLAVLLAAVADAQLSESFYARTCPGGVQAVANVVNNAVRNDRRFAAGLLRLHFHDCFVRGCDASVLLNSASRNAEKDAPPNLTLQGFAIIDQAKAALERTCPGVFSCSDILALAARDAVSFIGGPRWRVPLGRRDGSISRAAEANSQLPTTRMGFRALAQNFARKGLSESDMVILSGAHTIGLTHCRDVTPRIYNFAGSRDGADPYLNRTYVTEKRRACPNTRAAAGNFVNLDSSLGGQRFDKNYYENVLNHKAVFNSDDALIAVARGLNQVRSIVRNPQSTFFSQFGAAMEKMGRISVLTGSRGQI... | 14 |
F1QJL2 | 5.4.99.12 | ACT_SITE 60; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1" | MQQTVARYLIFFQYTGSKYSGVMKAPAHQAVQGVGNHLENAVRKLKPVNEVCVSISSRTDTGVHALCNSAHVDIQRRADKPPLSEQSLLEALNFQLKEEPIRITRAYRVHSDFHARYQAQSRTYVYRLALGCQHHTLMPLTEKDLCWALRDTRLNIDAMREASALLLGTHDFSTFRALSSDAPFKCPVKTLDLAQLEPGESFSQRHFQRDIQFWELTFKSRSFLYRQVRRMTGVLVAIGQGRLSVSKIQDLLEARDSLAFPNNLTAPAHGLFLTNVQYRDTDLVASMSEEQ | 217 |
A0A2I3RMA9 | 2.7.10.1 | ACT_SITE 655; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MEARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQ... | 97 |
D7TIY3 | 2.3.2.26 | ACT_SITE 1129; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDDHRKHQVSLRGASAKEITRDALLEKVSQERELRNYVRRATAAAIFIQRVWRRYNVIKMVAVQLQEEWETLVNHHAVLMTRTWISSSFLRPFLFFITYLSIRHQRIRTRDVDCIRHCFKTLLESINSTDSKMNFCSLATGTPEERRIWTYEAEKLISICLFILAECDTHPGGQDINVLSSMAMRLLVVLTDTKGWKSITDDNFQDADRAVKDLVRFMGSRKGGLYLCIRKYFNKLDAPCSSLKNSVVQADERFLITASAITLALRPFQAANLDVTEPGPFNVQYAAEQYCVYILTIPWLAQRLPAVLLPAMKHKSILSP... | 65 |
P77972 | 4.2.1.11 | ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 341; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MLSKVPATIEEIAAREILDSRGRPTIEAEVRLESGAHGIAQVPSGASTGSFEAHELRDGDPKRYDGKGVEKAVRNVTEKIAPVVEGLDAFDQMAVDQAMIDRDGTDNKKELGANAILGVSLATAKAAAAELAIPLYRYLGGPLANVLPVPMMNVINGGAHADNNVDFQEFMIMPVGAETFKEALRWGAEVFAVLGKVLKERKLLSGGVGDEGGYAPNLTSNQQALDILIEAIEQAGYKPGSQIALAMDIAASEFFKNGQYEYDGGSHSPQEFIDYQAKLVSQYPIVSIEDGLHEDDWESWKGLTTSLGTKTQLVGDDLMV... | 200 |
Q383C5 | 2.3.1.48 | ACT_SITE 417; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MASLAAKKDGGDINGGPSEEEDQLQQLLGTSCCVNLSDSTVKRGFLLEVRYLWLPRLLSGNGTTGVAPQLYGFVRIKDADHRISGWFPIDCIDLKETGGANGATSCGSSYPTNSAAYNSMVVAKSKITHPIISPVYREVTPGMVRTRREGKQLDFFEERLLRDCRTPTTVRYFIYLCKFAFPPWYYAPYGMLNREYDPLAPLSDAEREALRFTEGSTNESIDTNPFIRDAYLCPFSLRIYSTFEQMQHETLRYRAGHLHPPGLEIYRDDTRGFSMFEVNGSRHVTYCRHLFLLGKSFLENKLAGHDVHNYYFYVVCLHHR... | 61 |
Q8IJ70 | 2.3.2.23 | ACT_SITE 87; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | MNPQTSLTRKQCDFTKLIMAGYDLELNNGSTQDFDVMFHGPNGTAYEGGIWKVHVTLPDDYPFASPSIGFMNKLLHPNVDEASGSVCLDVINQTWTPLYSLVNVFEVFLPQLLTYPNPSDPLNSDAASLLMKDKNIYEEKVKEYVKLYASKDLWEQQKKEKKPSNINGNISPVSELSYVDQDVQDIDLDNL | 64 |
A0A0A0KVN5 | 3.1.1.11 | ACT_SITE 166; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAQPRVLTVAHDGCADFCTVQEAIDAVPFSNTCRTIIRVSPGIYKQPLYVPKTKNFITFAGLNPETTILTWDNTATKINHHQAARVIGTGTFGCGSTIVEGEDFLAENITFENSSPQGSGQAVAIRVTADRCAFYNCRFLGWQDTLYLHYGRQYLKDCYIEGSVDFIFGNSTALLEHCHVHCKSKGFITAQSRKSSQETTGYVFLRCVITGSGETSYVHLGRPWGPFARVVFAYTHMDVCIKPAGWDNWGKAENERTACFYEYKCFGPGSCSMKRVCWARELLDEEADEFILHRFIDPDVDRPWLCQRMALRIPFSA | 125 |
Q4Q5C3 | 5.3.1.8 | ACT_SITE 292; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MSELVKLEAGHQDYAWGKDAASSFVAKMKGLTNDKSGKMFAELWVGTHPNCPSKIADGNAQLLEDFLKQPENKKTYFSEAHQATIFRDTVPYLLKILSIRTALSIQAHPCKKLAEELHAARPDKYKDPNHKPELICALTSFEALCCFRPLGAIIAYLKRIPELAELVGADAVLGQYMMAPESALPAADSDEEKQSLKAMMTNVYAASDDIVAKTLRLHLQRIEETGAQCAEDELFARIYRQYPDDVGCWMVYFLNYVQMVPGEALFLSDSEPHAYISGDGVEIMACSDNVVRAGLTPKWKDVPTLISMLKYDTTGLASAS... | 214 |
Q7XPY5 | 3.2.1.21 | ACT_SITE 254; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MARRRMGEEGKGGGWGLNGRQCRFGNRLRAVKGEGWRSAVAAQAATGRREEDDAGGREKGEKRERKGGLSPCLFGKRRRERRRGGRGRREALPPSLGGLRAERRGRGDDDVLINYNVQHVSRIKLEERLLITDKLSLRFLDPIFFGEYPREMREILSSNLPKFTPEEKKLLQNKVDFIGINQYTAIYAKDCIYSPCALNTYEGNALVYTTGVRNGAKIGKPTAFSTYFVVPESIESAVMYVNGRYKDTTIYITENGYSQHSDTNMEDLINDVERVNYLQGYLKYLSSAVRKGANVGGYFMWSLIDNFEWVFGYTIKFGLY... | 161 |
Q7S477 | 1.8.1.4 | ACT_SITE 483; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MLSQRLIGRAAVRSAFKPSGLPVVVSPRLRRTYATESEEKDLVIIGGGVAGYVAAIKAGQEGLKVACIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDSKHRGIEVGDVKLNLAQLMKAKEQSVSGLTKGVEFLLKKNGVEYIKGAGAFADEHTINVKLNDGGETSVKGKNILIATGSEVTPFPGLEIDEKRVISSTGAIALEKVPEKMLVIGGGIIGLEMASVWSRLGAQVTVIEFLDQIGGPGMDLEVAKSIQKILKKQGINFKTGTKVVSGDKTGETVKLEVDSAKGGKPETLEGDVVLVAIGRRPYTEGLGL... | 36 |
H2MUM2 | 2.7.11.13 | ACT_SITE 336; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000554-1" | MPTLRDSTMSHPGENSHQVRVKAYYKGDIMITHFEPSISYEGLSGEVRDMCSMENDQLFTMKWIDEEGDPCTVSSQLELEEALRLYELNKDSELIIHAAEVSIYRRGARRWRKLYYASGHVFQAKRFNRRAHCAICSDRIWGLGRQGYKCINCKLLVHKKCHKLVTMECGRPVMQVRNTYSRESLEDYVEEKEARSSRDAGKSPSSLGLADFDLLRVIGRGSYAKVLLVQLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEI... | 100 |
A0R2N3 | 2.3.1.286 | ACT_SITE 104; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MQVTVLSGAGISAESGVPTFRDAETGLWAQVDPYEISSTDGWQRNPEKVWAWYLWRHYMMARVAPNEAHRTVAAWEDHLDVRVVTQNIDDLHERAGSTNVYHLHGSLFEFRCDACGSAFEGNLPEMPEPVETIDPPVCPCSGLIRPSVVWFGEPLPDAAWNRSVLAVSSADVVIVVGTSSIVYPAAGLPEAALAAGKPVIEVNPERTPLSDSATVSLRETASEALPTLLQRLPELLNRSA | 58 |
F6I4A4 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFHQRPSSSHGGTPSKHLSWGCTIFLVLALTTAVSGLASSSHTSTVPKASMEAIVSAACKATFYQTACQSALLSSTNGAVPQTQADLFDLSVQFSLNQARSARAHVHDLRLLDHKTQIVRGTDDCMELLDDTLDQLTNVANRRKTLIEDPDDVQTWLSAALTNQATCLESIQTYQTGGQNGLMRPMAQNLTYSISNSLALHMSTRPSKEAQRTNTAGHHRRLLSDRFPGWVTAAERKLLEASVEEIGATAVVAKDGSGTHKTIGEALAMVVTLEGEGRTVIHVKAGTYDEGLKIPSSQKNVMLVGDGKGKTVIVGHKSYA... | 125 |
W5MIN0 | 2.7.10.2 | ACT_SITE 1004; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MSRISAMELGRQLCGKMRKTKKTEAIISTPMKGLEIHFYLCDSHQLEYLSGSYLVEDLCIEAAKKCGISPLCYNLFALYDESRNIWYPPNHTFTIDEGTAIKLHYRMRFYFSNWHGTNENESLVWRHSLHKQKTEYGPKKVPEGTPLLDAASLEYLFAQGQYDFLKGLAPVRSPQNENETHDIENECLGMAVLAITHHTMRKSMAGSAGETRKQINYKKYIPETLNKAIKQRNFLTRIRINNVFKSFLNEFNNKTVTDSNVTMHDLKVKYLSTLETLTKHFGTEIFETSMLQICVENESCLPYNKEQPLYEIQVSGKMGI... | 98 |
A0A9R0K3T4 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKRILSVIVICSLISHSQAALEVGFYRDKCPFAEAIINHEVKKSYLIDKGIAAGIVRLQFHDCFVRGCDGSIFIDSTPTNQAEKDGSTNESIRGLEVIYNAKDKLEAVCPGVLSCADILAYAARDSNVLSGGVYWDVPAGRRDGRISRASEIVDIPLPSFNLVQITESFANKGLTQADMVALSGSHSIGRSHCFQFTDRLYNHNTKTMQDPNLDPHYAQLLRIVCPKVLQEIFNQTLVVGMNQSPFYMDSSYYGNLFKHAGLFVSDQSLLDSQTTATQAASYAANDLSWKVDFAQAMIKLSQVQVLTGNQGEIRANCRVI... | 14 |
A0A803T1T9 | 1.11.1.6 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MECHRDYAKEQLEHWQEQCGRQGPPALTRAAGIPVGNHRNVLTVGPRGPLLVQDVVYAEQITHFDQERIPERVVHAKGAGAFGYFEVTHDITQYCKAILFEHIGKRTPIAARLSAVVGESGSADTVRDPRGFSVKFYTEDGNWDFVGNNTPIFFIRDPMLFPSLIHSQKRNPQTHLKDANMSWDFFSLRRESLHQVSFLFSDRGIPDGFRHMHGFGSNTFKLVNACGKAVYCKFHAKTDQGIKNLTVEKAEKLASKDPDYGLRDLYNAIANGDYPSWSFYIQVMTFEQAETSPFNPFDVTKVWPHGDYPLIPVGKIVLNR... | 13 |
A0A1D5RIZ5 | 2.1.1.37 | ACT_SITE 643; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MEPSPEPPSLESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPCPSPASSYLTIDLTDDTEDTRVTPQSSSTPYARLAHDSQQEGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEK... | 47 |
P35992 | 3.1.3.48 | ACT_SITE 1468; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MLYQLSKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTF... | 149 |
A0A0D1DRT0 | 2.7.11.23 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | METAAAQNLLIANSYAKVEKVGEGTYASVFLARSINTGQKVAIKKIKIVSNENGMDVTAIREVKFLKELNHPNVIKLVDVFSSGSRSPSLNLVLEFLDTNLEALIKDRTLIFTQADIKSWMAMLCRGLEYCHRYWVLHRDLKPNNLLISPQGELKIADFGLAREHGDPGARMTHQVVTRWYRPPELLLGSRAYSSAVDMWSVGCIFAELMLRVPYLPGESDADQLITIFKALGTPTDKDWPGHKSLPEYTAFEQYPKSNLADLFLAASPEALDFLQKMLLFDPLKRLSANQALHHAYFKQGPPPTPFKQLPRHPTKALDS... | 103 |
B9IJU9 | 5.1.3.3 | ACT_SITE 193; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKVTVLLCFCILAVFGSVNAHTGKEKVGIYELKRGDMSLKFTNWGATLVSFVLPDKNGKLIDIVLGYDTIKQYKNDTTYFGAIVGRVANRIKGAQFKLNGHTYKLVPNEGKNMLHGGPKGYADVVWEVTKYQNKGHKPHIVFSYHSFDGEEGFPGEILVTVRYTLLADNQVTVVMKAKNIGNKATPVNIANHAYWNLGGHNSGDILSEKIQIFASNYTPVDNDLIPTGKIEAVKGTPFDFLKPEAIGSRTRQLPKGYDINYALDGVHGGKIRKAAVLQDEKSGIEMELSTNAPGLQFYTGNMIKDVKGKAGFVYKAHAA... | 211 |
A0A067H5N1 | 3.1.1.11 | ACT_SITE 404; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASKLFFLITIPILIALPFFAYPSYAADNVDPPTTPVPPETICMYTPKPKDCKSVLPATPNQTADTYTYCRLSIRKALSQTQKFFNLVDNYLKSGSTLPLSAIRTLDDCRLLAGLNLDYLSSSYQAANTTSRILKTIQADDVQAQLSAILTNQNTCLDDIQDSALSESVKNGLSVPLLEDIKLSSVLLALFRKGWVGEKKIVTSWQPSKTQSMFGHNGRLPLIMSDRIRAIYDSVRGRKLTGGDEGVLVIDIVTVALDGTGNFSTITDAINVAPNNTNPDNGYFLIYVTAGVYQEYISIPKNKKNLMMIGDGINQTIITG... | 125 |
C3Z724 | 2.3.2.23 | ACT_SITE 97; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MSGSSNVENLSPQIIRQVAKEVLDLANHPPEGVKVFPNEQDITDVQATIEGPGGTPYEGGQFKIKLSLGKDFPQTPPKGFFLTKIFHPNVAKNGEICVNTLKKDWKADLGLKHILLTIKCLLIYPNPESALNEEAGKLLLEQYDNYSERARMMTEIHAKPTTKTAPTKNEETNCPSTSGTQSTSEGPMAKKHAGDKNAAEKKKKEKKRALRRL | 64 |
A0A3Q7EGN4 | 1.11.1.7 | ACT_SITE 105; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKILFSVAWDDAKNEDYSRKSTWGARNDEDVPRNEENGERNAWGLSNAWDALKNVWGPRNSNVPRKNYYQSTHCPNVEQLIRDITWSKVAQDPTLGAKLLRIHYHDCFVKGCDASILLDKVGSDDSEKEARPNLSLAGFEVIDDIKREVESKCPGIVSCADILALVARDAVSYPFKTSMWEVETGRKDGFVSLASNVNGNLPSPFSDFATLKQIFANKGLNVDDLVALSGAHTIGVAHCGAFSRRLFNFSGKGDMDPSLNATYAKDLKDVCPNPANPATIVEMDPMSSTSFDSNYFNILINQNKGLFQSDAALLNDKDSV... | 14 |
A0A9K3N4X6 | 1.11.1.7 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MYEVYLSPCFLAPPYMVDFQSPTKTIYTDPPCNVSTSTSHLRNTLLNLKDKSLLLLLMEISSLSKTVALLVLLLATLTTLSLGQGNRGSGRGTRLGYYRSSCPRAESIVQSAVRSAVQANPTIAPGLLRMFFHDCFVNGCDASILIDGPTTEKTAGPNSLLRGFEVIDAAKSQLETACPGVVSCADIVALAARDSVVLTGGRSWQVRLGRRDGLVSQASDTANLPAFNDPISVQIRKFADKGLNTQDLVTLVGGHTIGTAASCPGVISCADIVALAARDSVVLTGGCSWQVRLGRRDGFVSQASDTANLPAFNDPISVQI... | 14 |
A0A0K9NY40 | 3.1.1.11 | ACT_SITE 367; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDFKTVFFFLSSITIFSVISVTGGNSTFQVAQIHCNGTLYPSLCMSMVSSIPEVKSKSLPHVISHIIAHTTIAVRRSSRKCSKLLHKRHRHLQLRQRLALTDCLELFDSTIEDLESARFDMLSTTDVSSYYHDLQTILSAGITNQGTCLDGFSDDSLRYSISKGVRHISQLVSNSLAMSKKLDNGAGSEMFYRGGFPEWMTRKDRRLLQSPLESMKIDLVVAKDGTGDYKTISEAVAAAPNKSKTRFVIYIKKGGYFENVDVPSYKPNLMFIGDGMWKTVVKSYRNVVDGWTTFRSATVSVVGNGFLARDMTFQNSAGPS... | 125 |
Q6PEE3 | 1.17.4.1 | ACT_SITE 138; /evidence="ECO:0000255|PROSITE-ProRule:PRU10014" | MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGK... | 21 |
A0A251Q650 | 5.1.3.3 | ACT_SITE 229; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 360; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MPLTLFSCKPINLFNSPHPIKLLSHIFSFFAKNNMAKICVLLCFILLAASGFANVSGSEPKEKKVGIYELKKGDLSVKFTNWGATIISLVFPDKNGKLADVVLGYDTIKEYTNDTSYIGAIVGRVANRIGGAQFTLNGTHYKLVANEGKNVLHGGLIGFSDVVWKVQKYQNEGDAPHIVFTYHSADGEEGFPGDLLVTVSYTLLGDKQLSVKMKAKALNKPTPVNLAQHTYWNLGGHNCGDVLSQYIKIFASQITLVDSHLIPTGKFASVKGTPYDFLKPKAVGSRINKLASGYDINYVLDGGAGNKLKPAAVVYDKKSG... | 211 |
B9SRK8 | 2.3.2.26 | ACT_SITE 1136; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDEPRRHQVSLRGASAREISRDALLEKVYHERELRSYARRATASAIFIQRVWRRYIVTKKVAFQLQEEWESMLNHHDGSITASWISNSLLRPFLFFVACSSTRHQKICTRDIYCMQTCFKILLESINCTDSRKNFCSLSVGSLEERRMWTFQSKKLICLCSFILSECDKSHAVGHDIVVLTSVAMHFLVVLTDLNGWKGTTNSNLEDTNVAVNHLIRFMGSCKSGLYISIRTFINKLDIHVSSQTKNMVQTDDKFLITATAVTLALRPFHASSLKVTGSDLLDMDSAVVQYFLFILTIPRLIQRLPAVLLSALKHKSILS... | 65 |
B9RA19 | 3.1.1.11 | ACT_SITE 223; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAKQITYIAIIHYVIAAILLAATTVISDDATPIPAAENQVNSWFQANVKHFSSRKGTLDPALLAAEAAPKRIKVRLDGSGDFKSVTDALKSIPSGNEHRVIVDIGCGVYTEKVTIDRIKPFVTLLGSSKHMPTLQFAGTAKKYGTVYSATLTVEADYFVAANIIIKNTAPRPDGRAGAQAVALRVAGDKAAFYNCRILGFQDTVCDDKGRHFFKDCYIEGTVDFIFGSGKSLYLKTHLNVIKEKFMTVITAQAKHTSSEDSGFSFVHSSITGDATDAYLGRAWMEMPEVVFSYSKMSKVVIPAGWSNYNHPEREKNILFA... | 125 |
Q57690 | 4.1.3.27 | ACT_SITE 80; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 168; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 170; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605" | MEVKKVLVIDNIDSFVWNLVQYVGTLGYKVKLVDNKITLDEIKKINPDRIIISPGPKTPKEAGNCIKIIQEVDIPILGVCLGHQCIVEAFGGEVGRAKRVMHGKASLINHDGEGIFKDIPNPFYGGRYHSLIAKEVPKELKITAKSLDDNYIMGVRHKKLPIEGVQFHPESILTESDNLKFPDLGLKLIKNFVESEY | 198 |
A0A1L8GKJ1 | 3.1.1.4 | ACT_SITE 77; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 128; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MRSRTVLALLLTVHFFALVSSALTHRQSRNLAQFSNIIKCAIPGSRPLLEFNNYGCYCGLGGSGTPVDELDKCCQIHDNCYDKAKHMNCIPVLQNPYTETYSYTCTDNNMISCDKNNSECDMHICNCDLNAALCFSRASYSKKHKNLNKDKHCQ | 130 |
A0A0A0KGQ9 | 2.4.1.18 | ACT_SITE 425; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 480; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MLLSSCVLPSTAVASLSLSAKKIIISDSRNQWPSLRQQTELNFWSRMSHHRQMNPFVFPYSTYKRVHSPAISSVMTEDTSTVSSTDESMENIGILSHDPGLKPFKDHFKYRVGRYTDLLNLLDKHEGGLDEFARGYLKFGFNREEDGIVYREWAPAAQEAQIVGDFNGWDGTNHCMEKNEFGIWSIKVYDLGGKPAISHNSRVKFRFKHGNGVWIDRIPAWIKYATVDPTKFAAPYDGVYWDPPPLERYEFKHPRPAKPNAPRVYEAHVGMSSSEPRVNSYREFADFVLPRIKENNYNTVQLMAIMEHSYYASFGYHITN... | 73 |
Q7SD45 | 2.7.7.7 | ACT_SITE 551; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MSFQTLAEKVAFFEVLDALSETISDDEKFDTQEQEHRARSKAFFSSKAKPKPKSNPNIPTIPQTQPPAATLSTPLSKTSSRVDIIKATPGARDLRKTALKNTTDTPSVSDTSLVVTETPQPSTSSARPVPPLLQRSATLPIPSTTRLVSSPHHQQSPSGTSSTRKRKRQAEANAVPEADQIFRTLMFFYIPNDNVAPARRLRIARAQQYGAKWVRSLEKATHVIVDKRLAYHDIQSVLEATPTTSAPVIVNEDYPIDCIQFRTILNADQARYHIPGRPHPASPTLIAQATDTHAPSQISNRSLQVKVSTAKRRKQVPSSQ... | 121 |
W5MKZ4 | 2.1.1.37 | ACT_SITE 1223; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | LFVKQTKFKLEMPAKTSLSLPEDVKKRLQVLDTDGDGLTDEERVRETLSLVLGYLKADAQNQLNNLESKLKKEELSVEGYLSKVKALLGRELCLENGSSELNGQANGCAENGAHGASDEDCGPRNGQGAEGTVEAREEEGLKSPSTGKPRGGRRSKTEGDTKIYVSLSPGVLRGWIPNCVMYTNPFYNQSSFPTGGVPCDTLVGESGKCWRTLAIRKQGGRRRRNSEPGRMLRQISESFSSSRVTRNSVKQPTILSMFAKSSSQPTSLGLLFNVFSIVESPLPSSSKRKSDEVNGEEVAPVTEEGVTDDEEKAQDEKRLK... | 47 |
F6VF91 | 4.1.1.50 | ACT_SITE 75; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 89; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 243; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MSVVDVKDGAPQSWFFEGVEKLMEIWFSSSAPDGPKKGANLIERWKWENILTHVHCKILDEMKHQDQTAYILSESSLFVSRERIILKTCGTTLCLQALPFIIQLVQDECGFDTVADFFYSRKNFIKPDNQPHPYKTFQDETVYLDTILSESASYCLGRMNRDCWYLYTLNHPENTSLIGVNQPDQTLEILMTNLSVESMQKFTRCDEKGNVRNAAKFTEDIGISDILPGSKINSILFDPCGYSMNGLLDKNQYWTIHVTLEPEFSYVSFETNVIMKDYKELIGKVLNLFQPQVVSMTLFANHVSKNKVHKSFYIKVPGYK... | 196 |
K3YZ47 | 3.1.1.11 | ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | METFGGATSPERQAKMRLPVVAWSCAMATVLALGTVVPVAEARKGDDNVAAVSRICRSTPYPSACETALTSAEARRARDPFAASVQFAMARARTARSLARNLSASAPPTAMHDCAELLDISLAQLRDALAGRAADAAGATTWLSAALTNQGTCNDSLAAAATPKALAAGRGAVRKQVAALAQFISTALALHVKRVKGGRGVPPSAATAAPSPKSSTFPSWLSEHDRKLLESPATDVITADAVVALDGSGTHRSINEAIAAVTSPVDTEAGGGREAGRARRKVIKVKAGRYKESVSISYQQENVMLVGEGKGKTIIDGNKS... | 125 |
G1KJ78 | 3.5.1.98 | ACT_SITE 859; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MSSQSHPDGLSGRDQPVELLNPTRVNHMPSSVDVTTTLPLQVAPTVVPMDLRLDHQFSIPVAEPTLREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEILAMKHQQELLEHQRKLEQHRQEQELEKQHREQKLQQLKNKEKGKESRHLFDDSLNTVLMEIKNPVKMEDEKLKTSHILLFQAQARPGTAVPQQKVYLGAVASTEVKMKLQEFVLNKKKALAQRNLNHCISNDPRFWYGKTQHSSLDQSSPPQSGVSGNYNHPVLGMYDSKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPL... | 184 |
A0A3B6AR18 | 2.3.2.26 | ACT_SITE 1915; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPAHPAPTRARRSVVLSPPAPQPPMDFPADGGNNPPPRRRGGRASNADKGKEQQEPSESSRVREAERMLGLSFDGMDDDDEGHGAFPHGLTSASSALQGLLRKLGAGLDDMLPSSALSAAAAAASSSSMSGPNGTRMKSMLAGLRADGEEGRQVEALTQLCEMLSIGTEDTLAGFSVDSFVPVLVGLLNHESN... | 65 |
D6X017 | 4.2.1.11 | ACT_SITE 219; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 353; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MKRTFSSAAKTLVKKIQARQIFDSRGNPTVEVDLVTDLGLFRAALPSGASTGVHEALELRDKDKANYHGKSVFKAIKNVALIAPEVIKSQLCVTQQCQIDEIMVNLDGTENKSKLGANAILGVSLAVAKAGAATKKVSLFKHLADLAGNKDIILPVPAFNVINGGSHAGNKLAMQEFMILPTGAKSFTEAMKMGSEVYHHLKNVIKAQFGLDATAVGDEGGFAPNIQNNEDALNLIIEAIKKAGYEGKIDIGMDIAASEFYKDGQYDLDFKNPKSDKSKWISGEKLLEMYKGFIKKFPVVSIEDPFDQDDWTSWSAITSS... | 200 |
A0A251VCX8 | 3.1.1.11 | ACT_SITE 416; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTTTFTFIATLVSFLLPLVAAYGYNDLEITSWCGQTPHPESCNYFLANNQYYSGPVIKQKPDFVKALLKVTLERAQHAESNTRGLGPKCRNKLEKAAWDDCIELYEHTVERLNMTVDPHKPCNQYEMQTWLSTALTNLETCRAGFQELGVDGYMLPLMNNNVSSLISNTLAMNKEGGSPPDNYQKGGFPTWVKPGDRKLLQSSNPASQANVVVAQDGSGNYKTIGEAIAAAAKRSGSGRYVIYVKAGTYKENIEIGTKLKNIMLLGDGIGKTIITGSKSVGGGATTFNSATLIVVGDGFIGRGITVRNTAGPQNHQNIML... | 125 |
Q9XTC6 | 2.7.11.25 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:O43318, ECO:0000255|PROSITE-ProRule:PRU00159" | MDNSSQSKPSSSSSSHSPSPAAITPTQRTTRDSGLCSTIDIPEIQAQCIDNLNSHYLGKGTYGLVEKTRYRKTRQDDFRPAAIKYSSQLHMATLIREAKVMWDLRNHPNIIKIYGLYKSPRNGQGVVMEYMDCGSMADLLYDRTHINYTIDHVASWMFQLSSAVDFFHSNSQVHRDLKLQNMLLSDRYRTMKLCDFGTFTSMHQSMTSNRGTPITMAPEVFRCEQYNMKSDIYSIGIIMWQIIARNHPYRRDLSVPGLLYNVATANLRPQELECNPILSEFYKKCWNDNADIRPTSSECVEYFTLLKDEYPNGSVPLSDS... | 105 |
Q6R3M4 | 2.7.7.7 | ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00216" | MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAK... | 121 |
Q02157 | 3.1.1.3 | ACT_SITE 170; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"; ACT_SITE 281; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037" | MLLLWALPLLLGAVAGLEVCYERLGCFGNRIPWSGGTLERPFSTLPSTPKIVNTRFLLYTNENPNNFQEISADASTIRGSNFRTDRKTRFIIHGFTDKGEENWLSNLCENLFQVETVNCICVDWKGGSRTTYPQATQNIRIVGAEVAYLVGTLQSSLGYSPSNIHVIGHSLGAHAAGEVGRRTNGTIGRITGLDPAEPYFQGTPEIVRLDPSDAQFVDVIHTDAAPMVPNLGFGMSQTVGHLDFFPNGGKEMPGCQKNVLSQIVDINGVWEGTRDFVACNHLRSYKYYADSIVNPNGFAGFSCASYTAFSANKCFPCSNG... | 128 |
A0A059AD62 | 2.2.1.1 | ACT_SITE 490; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MAISSLLHNQYPSFCSYRRSKLSAKSIACSSLKTQDCKPAAQRSSLSRDDKLSWKEELKKAYQREIPNLNWDKLEELEDESFQNLVDKRCVDNVRMLIVDSVQNAKAGHPGMALGMAGVLFLLYRHVMKYNPKNPKWFNRDRFVLSAGHGCLLQYVCLHLAGFESVQIEDLKRLCQLGSRTPGHPENVVTSGIEVTTGPLGQGVANAVGLALAEAHLAARFNKADAVIVDHRTYCIMGDGCAMEGIAHEAASLAAHWKLNKLTLIYDDNHNTIDGPTTLAFSEDISARFKALGWHTISVDDIDADMRTLKDALFSAFSET... | 51 |
Q9LYT5 | 3.1.1.11 | ACT_SITE 355; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 376; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MATTSFSLPNHKFGIKLMLFLVLNLLSLQTSVFAHSSNSKFTKISRHPNSDSSSRTKPSTSSNKGFLSSVQLSLDHALFARSLAFNLTLSHRTSQTLMLDPVNDCLELLDDTLDMLYRIVVIKRKDHVNDDVHTWLSAALTNQETCKQSLSEKSSFNKEGIAIDSFARNLTGLLTNSLDMFVSDKQKSSSSSNLTGGRKLLSDHDFPTWVSSSDRKLLEASVEELRPHAVVAADGSGTHMSVAEALASLEKGSGRSVIHLTAGTYKENLNIPSKQKNVMLVGDGKGKTVIVGSRSNRGGWNTYQSATVAAMGDGFIARDI... | 125 |
W5MG69 | 3.4.21.92 | ACT_SITE 140; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 165; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | VVFRAANVCALDISPVNRLLHGGVSLLRGCRLMHHSAPCRSPLIPIVVEQTGQGRGERAYDIYSRLLRERIICVMGPIDDSVASLVIAQLLFLQSEGNNKPIHMYINSPGGVVTAGLAIYDTMQYILNPISTWCVGQAASMGSLLLAAGTSGMRHSLPNARIMVHQPSGGARGQATDIAIQAEEILKLKRQINTIYSKHTGQALDIIESVMERDRYMSPIEAQDFGIIDRVLVHPPQAGEDEPAVLQKEPTPSSAPCTPTEPSTNPQPPQGTPASSAKPEP | 179 |
A0A3B6RMS7 | 3.2.1.1 | ACT_SITE 229; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 254; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGKKNTHLCCFSLPLLLFAGLASGHQVLFQGFNWESWKQSGGWYNMMMGKVDDIAAAGVTHVAPAAVALCRQRRSSSGLPLPLPTKSFVPQHVRLFWFCYMPGRLYDIDASKYGNEADLKSLIGALHGKGVQAIADIVINHRCADYKDSSRGIYCIYEGGTSDGRLDWGPHMICRDDTTYSDGTANLDTGADFDHAPDIDHLNERVQRELKEWLLWLKSDLGFDAWRLDFAKGYSPEMAKVYIDGTSPSLAVAELWGDMVPGGDGKPNYDQDAHRQNLVNWVDKVGGAASAGMVFDFTTKGILNAAVEGELWRLIDPQGK... | 157 |
Q12674 | 7.6.2.1 | ACT_SITE 566; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000305" | MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADL... | 259 |
A0A9J7KSV9 | 6.3.4.4 | ACT_SITE 48; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 76; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 176; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MAENRGNIAPPRTANGDHSDPTEDGPLEKRLRYHGNKVTVVLGAQWGDEGKGKVVDMLGTDADVVCRCQGGNNAGHTVVVEGTEYDFHLLPSGIINDKAISVIGNGVVIHLPGLFEEAGKNEAKGLIDWQDRLIISDRAHLVFDFHQAVDGLQELEKGGKSLGTTKKGIGPTYSSKAARSGLRVCDLLADFKVFSDRFKMLVTQYERMFPNLKVDVDKELKRYEDLKERVRPMVKDVVHFLNTQLEGPQKKLLVEGANATMLDIDFGTYPYVTSSNCTVGGVLTGLGIPPRCIGEVYGVAKAYTTRVGDGAFPTELNNEL... | 253 |
A0A8I5ZR79 | 3.2.1.23 | ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 269; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MFRVPLCMLLPLLALLQLLGAAHSFYNVSQRTFELDYKRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLDAIQTYVPWNFHEPQPGQYDFSGDRDVEHFIQLAHQLGLLVILRPGPYICAEWDMGGLPAWLLEKESIVLRSSDPDYLAAVDKWLAVLLPKMKRLLYQNGGPIITVQVENEYGSYFACDYNYLRFLEHRFRYHLGNDIILFTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQRNFEPKGPLINSEFYTGWLDHWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNG... | 163 |
P38590 | 3.1.3.48 | ACT_SITE 319; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPLMEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASIYTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLKLKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNIDMVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQ... | 149 |
O77263 | 2.1.1.33 | ACT_SITE 160; /evidence="ECO:0000255|HAMAP-Rule:MF_03055" | MVATGGQAQDQGQNQEPDVLNPTSAVTGLPQKRYYRQRAHSNPIADHSFDYPARPEDVDWRSMYPGIQQGQQVSFADIGCGYGGFLVTLGEMFPEKLSIGMEIRVKVSDYVVDRIAALRRRCADTGAYQNIACLRTNAMKYLPNYFVKGQLEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYILRKGGLLYTMTDVEDLHKWIVTHMEEHPLYERLTEEEANADPITPKLYQSSEEGAKVVRNKGDHFLAIFRRL | 45 |
A0A078IUE2 | 2.7.11.1 | ACT_SITE 309; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 326; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MEEVIAEPPPTISPAIVDYDEHIEDDDDDSDLSISSDSDIGEALDWLDGKDDDELIGGGFSLHARRPNAHGGNGARPNSGALQPLSNKAQKLSSHVRASPLEAWEGRVEVGMSNSVTTAIRGSLRDTEIGRSRNTDKADRATVEQALDPRTRMVLFRMLNRGVFNDVNGCISTGKEANVYHATKSDGAELAIKVYKTSVLVFKDRDRYVQGDYRFRHGYCKHNPRKMVKTWAEKEHRNLKRLQAAGIRCPVPILLRLHVLVMEFIGRDGWAAPRLKDAALSLDKLRESYLELIIQMRTLYQKCKLVHGDLSEYNILYFEG... | 99 |
A0A2R6W9D6 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKTFSLLATCILFAAVAAPARAQLSVTFYNSTCPSGVSKVGEVVRSWITSDRTLAPSLLRLHFHDCFVRGCDASVLLDVANGEKSAFGNANSLRGFEVIDDVKAKVEALCPGVMSCADILSLAARDAMVEFGAAGLNWTVPLGRRDGVVSSAAEANSNLPPPFATFQQLVTSFSNKGFTTREMVVLSGSHTVGATRCSTIQGRLYNFSSTAPTDPALDANFAASLKTQCQFGDTTTKILMDQSTPVDIWNKNYYANVINGKVMFQSDDALKRVAAGKTFVQIMRAANSPFTPEFAAAMTKLSQVGVLTGTSGQIRTNCRA... | 14 |
Q9X8R6 | 4.1.2.13 | ACT_SITE 95; /note="Proton donor"; /evidence="ECO:0000250" | MPIATPEVYNEMLDRAKAGKFAYPAINVTSSQTLHAALRGFAEAESDGIVQISTGGAEFLGGQHNKDMVTGAVALAEFAHIVAEKYDVTVALHTDHCPKDKLDGYVRPLIAVSEERVKAGRNPLFQSHMWDGSAETLADNLSIAQELLARARAARIILEVEITPTGGEEDGVSHEINDSLYTTVDDAVRTVEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKELNEGIASKYGQPAGSKPFDFVFHGGSGSTAEEIATALENGVVKMNIDTDTQYAFTRPVVDHMFRNYDGVLKVDGEVGNKKTYDPRTWGKLA... | 197 |
A0A2C9VC76 | 2.3.2.26 | ACT_SITE 1539; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGNRGQKRVEMMDELPADKRACNNSLEFRPSSSNSSIQTQINSTNSTSETNDADMDTSSTGSASSRSEEEEHERDSAYGSCDSDDAVPKHGSLRIYQRQRSFGDHGRLRTALSNLSEGTEPSGQIAALTELCEVLSFCSEDSLSSMMADSLSPVLVQLARHESNPDIMLLAIRALTYLCDVFPRASGFLVRHDAVAVLCQRLMAIEYLDVAEQCLQALEKMSREQPLACLQAGAIMAVLGFIDFLSTSVQRVALSTVVNICKKLPTDCPTSFMEAVPILCNLLQYEDQQLVENVVICLMKIAERVSHSSEMLDELCKHGI... | 65 |
K3ZDQ6 | 3.2.1.52 | ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MEPALRLLLVLMVFMPCTGDVNVWPMPKSVSNGKQTVFISKDLKMTVVGSNYSDEKAILRDAFGRMVAVVEQDHVISESYERSPVLVGMNVVVRSRDDELNFGVDESYSLFVPSTGHPLYAQIEAQTVFGALHALETFSQLCSFDLESRQIILRSAPWSILDSPRFPYRGLLIDTSRHYLPVPVIKRVIDSMTYSKLNVLHWHVVDEQSFPIEIPSYPKLWNGAYSYSERYTKDDAIDIVQYAEKRGVNVLAEIDVPGHALSWGVGYPSLWPSAICKEPLDVSNNFTFEVIDGILQDFSKIFKFKFIHLGGDEVNTSCWT... | 170 |
Q9VQ00 | 2.3.2.23 | ACT_SITE 105; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | MEGLFSAEDGTPSCSWTCSNSAVKRIQKELDEITRDPPQYCSAGPKEDNLYEWTSTIIGPADSVYENGIFKLDIFFPVEYPFAPPVVIFRTPIYHCNIHRLGFICLDILKEKWSPALTISKILLSICSLLTDCNPKDPLMAKIGTEYLKNRAEHDKKARLWTKRYAKDE | 64 |
A0A067FVF9 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAFRVAFLTSLLILSMSSSGNALSLNYYEKTCPDAEWIIAAAVKAAAAKDKTVPAALLRMHFHDCFIRGCDASVLLNSKGSNKAEKDGPPNVSLHAFYVIDNAKKQVETLCPGVVSCADILALAARDAVVLSGGPTWDVPKGRKDGRTSKASETVQLPAPTFNISQLQQSFSQRGLSMEDLAALSGGHTLGFAHCSSFQSRINTNNADPTINPSFAESLRNICPIHNQAKNAGANMDASSATFDNTYYKLILQGKSLFASDQALLSHPETKNLVSKFASSHQSFNEAFVKSMIKMSSINGGQEVRKDCRVVN | 14 |
A9V986 | 2.3.1.48 | ACT_SITE 206; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MKRRYNEVNNLPTNEDVDATTAALELEHEKHTKVKFVNRIYFGVYAMDTWYFSPYPDEYGKSPALFVCEWCLKYMLQPTSLRDHDCQHRQPPGREIYRKGNVSVYEVDGAEHKLYCQNLCLLAKVFLDHKTLYFDVSTFLFYILTEVDADGAHFVGYFSKEKVSVDNNNLACICTLPPYQKKGYGRFLIEFSYALSQAEGKIGSPEKPLSDLGKLGYRSYWSWLLLNALRGKKGTISMPALSKATGIAPDDVFNTLQALNLTKYWKGEHVVCITPKLIDDLLATGKFKGPKVPVDVRCLRWSSPL | 61 |
B0G133 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MGIMKIGEIAPEFTLPNKDGKLFNLKDFAGKPLVIFFYPNNIGWVCTREVCYFRDSYEKFIEMGAEVPGNSPNTMDNHKKFHAAHRVNYTILSDKNGAIGKLYGVNGLLPGRVTFVIDKNGKIALNHHTSWLSHSSHIENSLSVIELLNSQ | 12 |
A0A0A0MQ23 | 3.2.1.52 | ACT_SITE 340; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | AAPALDLGRPAMRHRGLGLAALLALLAALAPRSSAAPEPALWPMPLSVKTSPRLLHLSRDNFSIGYGPSSTAGPTCSLLQEAFRRYHEYIFGFDKRQRRPAKPNSAIELQQLLVTVVLDSECDLFPNITSDESYTLLVKEPVAFLKANRVWGVLRGLETFSQLIYQDSYGTFTVNESDIIDSPRFPHRGILIDTARHFLPVKSILKTLDAMAFNKFNVLHWHIVDDQSFPYQSVTFPELSNKGSYSLSHVYTPNDVHTVIEYARLRGIRVIPEFDSPGHTQSWGKGQKDLLTPCYNEHKQSGTFGPINPILNSTYNFLSQ... | 170 |
Q8RIA2 | 5.1.3.3 | ACT_SITE 172; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 298; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MRYFFNSYGGKLEEIKVYTLENEFLKVEFLNLGAIIKKIELKNKNGDVKNVVLGYENIEKYRENPAYLGAIIGRTAGRIKDGILKIDDIKYQLDKNNNGNTLHGGKKSISHRFWNVGKIENGLCFSIKSFHLDNGYPANIEIKVSYILNNNELLIKYFATTDNLTYLNLTNHGYFNLNGNPNKPIYEDILKIDSDYLIGIDKNSIPCKTINLDNNIFDFRESKKLEEFFKADDEQKTLANNGIDHPYIFNKEIGKLEIKNLESGIKISVETDNPAVVIYTANYLQDIGFKKHSAICFETQEAPNLYRDEDINIYPTFIDK... | 211 |
Q8BLK9 | 2.7.11.1 | ACT_SITE 919; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MTSPWGHSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAYPDSPANAFPECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRTFGLSLSTDSSAVGAVASDSEPSRVEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRAAPQLHTGPQPPGS... | 99 |
Q55FN5 | 3.5.1.98 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000250" | MSTRKVSYFYDNEVGNHYYGPNHPMKPHRMRMTHDLVLNYGIYKKMQIFRPRKASELELTNFHSDDYINFLKLVTPDNMHDYSKQLVKFNVREDCPVFDGMYNFCQISSGGSIGCAVKVNSKESDVAINWAGGLHHAKKSEASGFCYTNDIVLSILELLKHHERVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGDYFPGTGDVKDIGADKGKYYSLNFPLKDGIDDESYQSIFRPIIRSVMDFYRPGAVVIQCGADSLTGDRLGCFNLTLRGHAQCIEFLKSFNVPLVVLGGGGYTIKNVARCWTYETSILVDSELK... | 184 |
P0CP66 | 2.7.11.24 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTIDQSQINFNVPSTYKLEEIVGEGAYGLVVAGTHLPSGTQVAIKRITPFDHTMFCQRTLREIKLLRHFHHENIISILDLIQPESYEVFNEVYLVQELMETDLHRVIRSQELSDDHCQYFVYQTLRGLKALHSADVLHRDLKPSNLLLNANCDLKICDFGLARSSAKPPPGTSDGGQGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWSVGCILAEMINGKPLFPGRDYHHQLSLILQVLGTPTMDDFNEITSQRSKDYLRALEFTRRQDFSAICPKAKPAAVDLLKQTLTFSPSKRITVEEALMHSYVEAYHDPHDEPN... | 104 |
Q7AKQ5 | 3.4.25.1 | ACT_SITE 54; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MEANTRSTGRLPAAFLTPGSSSFMDFLGEHQPEMLPGNRQLPPVQGVIEAPHGTTIVAVTFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGAQLSLEGKANRLSTMIRSNLGMAMQGLAVVPLFAGYDVDRGRGRIFSYDVTGGRSEERHFATTGSGSVFARGAMKKLFRDDLTEEQATTLVVQALYDAADDDSATGGPDVARRIYPIITVITEDGFRRLGEDEAAELAGSVLQARLEQPDGPRAALL | 180 |
A0A0G2JY48 | 2.7.10.1 | ACT_SITE 725; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | QMTSTLGCPLLTPSSWLDSGPELAKDWETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCPRVIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRAD... | 97 |
A0A1Y1HZA7 | 3.1.3.48 | ACT_SITE 115; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MDEAKLGRSPPYAMKLVRPGLYIGNAADAADEETLRKVSITHILCLAPTLSRASSALAALFGPPRSGQSSPAAPPFRRLELSVKDDEDQNLLDHLPECIDFIEEGRAKGGVLVHCVAGISRSGSVVTAYLMYKEGLSAKDALASLRQASPSACPNDGFLEQLSIFESMGNRIDERNTAYKMFRLTSLGRAWRGGEPVSPKFADDPNIGSRRSSANNLLEEGEDQLGGLPGDKKVVCYRCRKCRRAVAGVENVLPHDKGGGQSAFDWKKRSKSLDSGAIDDECSSYFVEPMQWMNSVHEGELEGKILCSKCQSRLGSFNWS... | 149 |
Q8C050 | 2.7.11.1 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 608; /note="Proton acceptor"; /evidence="ECO:0000250" | MEGEGGGSGGAGTSGDSGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKI... | 99 |
U5D3K6 | 3.2.1.143 | ACT_SITE 314; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 332; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 333; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MEERGDLRSVLPLLPLVMRDSSHSWPRRVLEALKAKSTGPELSLSRPRRVLEALKAKSTGPELSLSWPRRVLEALKAMSRGPEFSGLSNGHVLFDAIADLRKQLGFSDDNLATDSGHGYSLFFDDLMSGEESIKWFGETLPSMACLLMHLPSLLEAHYRDCDKSREIEERGLPIGTGLRVLESQEAGMVVLSQELIGALLACSFFCLFPSIGRSFRNLPTINFDYLFVSIHNSYSPSQKHKIKCLVHYFERICSCMPMGFVSFERKVLPLNGSSLHISYPKTDFWSKSIVELCPFKVLHSGVIEDQPYEALEVDFANQYF... | 159 |
F7ASA8 | 2.7.11.1 | ACT_SITE 343; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MRTGRGAERRDIDWSGRFWAPPSFLFSTSVAIFVPGMPVLVVSLFNALGSSLQQPWGRPGANISPFIFHQQSQCWGLTGDLESQCNMDISKENSVSGPSNKTAILLGEGPKRVPITQQISSQSRLPGSSGQAQRVLCSSNPLLVSSQAQKNISSHKTSHAHQSQKLQQAPVIHPTSRPPSSTQNTEQSQPPVSASIPGKGETPRQKNEETKKRQWALDDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYRELQKLSKFDEQRT... | 99 |
M5WGJ8 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGIPKLLGVFLVMEMMSGFRFGAHGLSMGYYVMSCPMAELIVRNSVIRALQADPTLAAGLIRMHFHDCFIEGCDASILLDSTKDNTAEKDSPANLSLRGYEVIDAAKEELEKECPGVVSCADIVAMASTYAVFEAGGPVYDIPKGRKDGSRSKIQDTINLPPPTLNASQLIKMFGQHGFTAQEMVALSGAHTLGVARCSSFKNRLVDAVDPNLDSGFAKQLTKTCSAGDNTEQPFDGTRNHFDNLYFNALQHNTGLLASDQTLFSSARTRNIVNGYAFNQAMFFFDFQQAMVKMSMLDVKEGFKGEVRQNCRKIN | 14 |
A0A7M7NZ19 | 1.2.1.12 | ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MVIQVGINGFGRIGRLTLRAALENSEVQVVAVNDPFIDLEYMVYMFKYDSTHGQFKGDVKCESGNLIVNGKKIKVFQQMNPSEIPWGENGAEYVVESTGVFTTIDKASAHMRGGAKKVVISAPSADAPMFVMGVNEDKYEAASMNIVSNASCTTNCLAPLAKVINDNFGIEEGLMTTIHAYTATQKTVDGPSAKKWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPVPDVSVVDLTVRLKKPASYDTIKKTVKAASESKALGRYLGYTEDQVVSQDFRGDMHSSIFDAGAGIALNDNFVKLVTWYDNEYG... | 22 |
H2N0T0 | 2.7.10.1 | ACT_SITE 765; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MSCGAQRARAPPLRSPSQSAARAGAGKLFQMDFPLGNWLFFSLCLLITRTVITLQSNEVVLLDMRKVGGELGWLTLPLKEPGWEVTQRTLNGSQFYTYSVCNVEEREQDNWLRTTFIQRGASVSRVFVEIQFLVRDCNSFDGGSLTCKETFNLFMSESDADVGMTFRKGQFKKVATVAPDKISGKGEMNINTETKVVESLSRKGFYLAFQDIGACVALLSVRVYYKICPEKVMELALFPETVASPGLRKVNGKCVDHAVAAELPHSHCSADGDWVVQVGRCLCQAGYEKVKDSCQGCQPGFFKAEASNRSCEACPANSQA... | 97 |
W1PK41 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGLSIEMQLLLVLSLSLIPNFEAQLEVGFYSQRCSPAERIVKDAVRSAVSNDVGLAADLIHMYFHDCFVRGCDGSILIDSNSTNTAEKDFFANKISLRSFGVLDSAKSKLEDMCKGVVSCADILAFAARDAAEMVGGIGWDVPAGRRDGRISLASENLANLPAPTFTVPQLTQLFLSKGLTQEEMVTLSGAHTIGRSHCTSFSNRLFNFSSTSSQDPSLDPRYATQLKSKCPKGNTNTNLVVPMDPLSPTVLDNAYYKNILANRGLFTSDHALLSDPSTSSQVSEYAANVFLWRTKFGAAMVRMGQIGVLTGNAGEIRRN... | 14 |
A0A1U8JW26 | 1.1.1.100 | ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAVAASSVIALNSVSIFGDSSDRKFLPTRQWSPISCRIGSVHTKPCIGLQCRSRSFTSSSVRAKRVEQASSEAAQEVEAPVAIVTGASRGIGKAVALALGKAGCKVLVNYVRSSKEAEAVSKEIESYGGQAVTFGGDVLKEANVDAMIKTALDAWGTVDILVNNAGITRDTLLMRMTKLQWQEVIDVNLTGAFLCTQAAAKVMMKKRKGKIINISSVAGLVGNLGQANYSAAKAGVIGLTKTVAREYASRNINVNAVAPGFIATDMTSKLGGDIEKRILTTIPFGRYGQPAEVAGLVEFLALNPASNYITGQVFTIDGGM... | 2 |
Q8EH82 | 3.4.21.89 | ACT_SITE 90; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 145; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MAAYFSIILVLVTLISGLIWLVDVLVFAPKRAARLLLAKESNASLTEEAEYSIMRESTIVETAHSIFPVIAFVLILRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGLKDPVWRTKLIETGEPKRGDVIVFKYPENPQIDYIKRVVGLPGDRIIYRNKQLMIQKACGVEQTQCPEPELVARTEVSRGDFSQDGVPLLRYKEQLGEVAHDILINPSRPDMLGYFKRDGDLPAGEFLVPEGHYFAMGDNRDNSTDSRFWGVVPEENLVGKAVAIWISFEFDRTKADFLPTWLPSGIRFERVGGIH | 178 |
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