Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A2K1J496 | 2.3.2.26 | ACT_SITE 1010; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MMFFSGDATSKKKVDLGGRSGKERDRQKLLLQTKLEREQRQRLRIQTQSAKQIQKFVRGRREVAAVRPIIRSEFCAIYGEFSERADRNAFLPSSKFLSLLFFFFQSSNDGDVQRLVGACRLLKQSLSQSKISELFTVERTISELALASHRQKRLASLCVHSLFINCMSMKMELLKDVHPSAISQDSSVLLETLLLLTSDDSLWGNDVMEHLMRNKLFYFFRYILLQLKPDAKQSTREKTYLEYVVCCLAKRYVQTMSAANILPIEWGFPCQVLSIPLLWQRYPSLKQVFVYEGLWGHSIHLIASNLSKFISLLPSDTTPE... | 65 |
H2MBW3 | 2.7.10.1 | ACT_SITE 826; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MWILSVLVWLATLSCCRAAETPGPPLLRLNSTIMPNQSEMVMLAGSAFSVNCQGNRSVKWSSTGIHWSQREETKTVKSANPRHTGTYTCGYTDQSLEHLNTWFHLYIKDPSNPSTVFVTPRQKIITLMEGKSFLFKCLLTDPSVTNLTLQRMDGRPLPPGMNVTLNPKRGALIQDVQVSFRGQYSCSGWRDRKQFRSSPLQLEIRALPPPPTLSVSQNYFVRLEGEPFEVTCQAVNQNHFVNVTWTHRSVKELKISVSRQHINNQLIIRSTLTVSAVSRTHSGEFLCTAYNERGVTTASVQLLVLDSPSLHLYLYLLAPS... | 97 |
A0A9R0I8G5 | 3.2.1.1 | ACT_SITE 194; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 219; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGFIYIHGFDDNVQQTDVAAATRKGREIVLQAFNWESHKFDWWRNLEKKMPDIAKSGFTSAWLPPASQSLSPEGYLPQNLYSLNSAYGYEHPLKCLLLKMRQHKVRPMADIVINHRIGTTKGYGGMYNRYDGILLPWDEHAVTSCTGGFGNRSTGDNFNGVPNVDHTKSFVRKDITEWLSWLRNEVGFQDFRFDFARGYAAKYVKEYIEGAKPVFSVGEYWDTCKYHSGRLAYNQDSHRQRIINWIDATGQIATAFDFTTKGILQEAVKGEYWRLRDSQGKPPGVMGWWPSRSVTFLDNHDTGSTQAHWPFPANHIMEGY... | 157 |
A0A251QN10 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAMYAPKTILFHTLICLLLTMASQSKASLNSNYYHQTCPQAEKIILQTVYNAFMHDPKIPARILRMFFHDCFIRGCDASLLLDSTPGNQAEKDGPPNISVRSFYVIDDAKAKLEMACPRTVSCADIIGIAARDVVTMSGGPYWNVLKGRKDGRVSRANETINLPAPTFNVSQLIQSFARRGLGVKELVALSGGHTLGFSHCSSFESRLRNFTSLHDVDPSMNNEFAQKLRKKCPKPNRDRTAGELLDSTSSTFDNDYYKQVVAGKGVFGSDQALFSDYRTRWIVESFAEDQSLFFKEFAASMVKLGNAGVIEDGEVRLNC... | 14 |
Q9URY1 | 2.7.11.1 | ACT_SITE 148; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKKNEKANISASYNDLIATICNPRISDVGTYRIESVVGEGSFGKVYLAAHLLTNTKVVLKSSCRKQAIILAREIHHHRRLLHPNITRLYEVVCTEDRIYLAMEYCPNGELYDWVAREKRLDEKTTCRIMWQLCCAIQYLHRQGCVHRDLKLENIFLDKAYNVKLGDFGFSRDSDCSRRTFMNTRCGTVAYCAPELVQGHKYIGECVDIWSLGIIMYALLIGRLPFDEDDVSLTEQKIINECPQYPETLSKNSSSLLKSLLCKDYRLRPSIDQIISHPYFKENGYHSSSIRDPRPSSKAEEKVRKRLEFVGVDMDQLNASI... | 99 |
O88354 | 3.1.1.3 | ACT_SITE 169; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 193; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"; ACT_SITE 280; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037" | MLLVWSLALLLGAVAGKEVCYDRLGCFSDDSPWSGIVERPLKVLPWSPADVNTRFLLYTNENQDNYQQITADSSRIQSSNFKTNRKTRFIIHGFIDKGEESWLANMCKKMFQVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVDFLRTQLGYSPSNVHVIGHSLGSHAAGEAGRRTNGAIGRITGLDPAEPCFEGTPELVRLDPSDAQFVDAIHTDGAPIVPNLGFGMSQTVGHLDFFPNGGIEMPGCQKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPTGFAAFSCASYSVFSANKCFPCPSGG... | 128 |
E7FH14 | 3.5.1.98 | ACT_SITE 842; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MLLKPTVPGLCAMLQTIYETESCFSSDSTSSRERPVELLPQSRSTSMPSTVDVKTLLPSGMQSPVGGGGDQGGGSGGPVDLRTDPRLSALSAVDPSLREKQLQHELLLLKQQQELQKQLLFAEFQKQHEVLTRQHEVQLQEHLKQQQEILAAKRQQELEQKRKLEQQRHEEMEKQRLEQQLIMLRNKEKGKESAIASTEVKLKLQEFLLSKKEPGPGGLNHSFPQKCWGAHHTSLEQSSPPQSNTPGTPPSYKLPPLLGSYEGKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAIEISVSSM... | 184 |
A0A7M7N3L2 | 3.1.3.16 | ACT_SITE 104; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 106; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MESTSIITQVNRDEEQINSFPTSESGPSSSKKPRSRSLLNTFLCCFGSGRHGTHQSVPQTSDQTDQRSLEHRPAPVNDPSTQPNKYLLPQVRQQDAHKCCIVIDLDETLVHSSFKPISNADFVVPVEIDGTVHEVYVLKRPHVDEFLQKVGQLYECVLFTASLAKYADPVADLLDKWGVFRCRLFRESCVFHRGNYIKDLSRLGRKLERIVIVDNSPASYIFHQDNAIPVSSWFDDMSDTELLDVLPLLERISQEEDVYKILKKENHNHIKR | 144 |
Q54XL6 | 2.7.11.1 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159" | MEINNSNNNNNYVCAQHNRIEHANHHDLPDSDSDSSSREEELMNSSGGGNGKEPIGEKKKLPSHISEVISNERRESIIRELQQIKTISDYPSQANQYNLIEPIGEGTEGRVFKAYCIPLKENVAIKVVELDKMDPQFVKDVIKEVKVMNGNNHPNLIHYHTSFLENNQLWLVMDYLGGGSLADIMKFKYPDGIPEVLAVTVLKSLLKGLEYLHSHQRIHRDLKSDNILIGEDGAIELADFGVSAMFEKNTCCSRKTIVGTPCWMAPEIISERGYNQGVDIWSFGITAIELIRGKPPGYDLPPSKVFMNLLFGNSPSLQEE... | 99 |
A0A1D8PS09 | 2.3.1.48 | ACT_SITE 424; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MVSHLLNQLKITNNHIYSNIVPQDLDKRTVRAKPTNDYSLKSMIKNNTHQKPTIPITNTTKIKSVHDDSNSNIKRVKRSFKHNNIFVKLTKKKCIVVINYDKTKLSTITRSKLDTVPLLPNSTSFTSENQNQNQVDTSILSEIQLPYKGILKYPDCIINDTDPTKLDTERFNKYLDEGIKLRNKTTCHLETETETETETETKTEIETELQSQVFSNLLHPILNESNQSTESTPVPNYSNLNKSKINRIVLRDFEINTWYIAPYPEEYSQCEVLYICEYCLKYMNSPMSYRRHQLKNCNFSNNHPPGLEIYRDQKSKISIW... | 61 |
Q9HT84 | 2.7.7.65 | ACT_SITE 592; /evidence="ECO:0000250|UniProtKB:P31129" | MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELREILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKPLKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESETTAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWVGVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPATPVDNLDGQAVDEAYELPPPI... | 120 |
Q5JJE8 | 5.4.99.25 | ACT_SITE 82; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01081" | MARDEVRRILPADIKREVVVKDEKAETNPKWGFPPEKRPIEMHIQFGIINLDKPPGPTSHEVVAWVKRILNLNKAGHGGTLDPKVSGVLPVALERATRVVQALLPAGKEYVALMHLHGDVPEDKILAVMREFQGEIIQRPPLRSAVKRRLRTRKVYYIDVLEIEGRDVLFRVGVEAGTYIRSLIHHIGLALGVGAHMAELRRTRSGPFKEDETLVTLHDLVDYYHFWKEDGVEEYFRKAIQPMEKAVEHLPKVWIRDSAVAAVTHGADLAVPGVVKLHKGIKKGDLVAIMTLKDELVALGKAMMTTGEMLQKSKGIAVDV... | 218 |
O24600 | 2.7.7.6 | ACT_SITE 694; /evidence="ECO:0000250"; ACT_SITE 769; /evidence="ECO:0000250"; ACT_SITE 926; /evidence="ECO:0000250" | MASAAAASPSLSLNPTSHFQHQTSLVTWLKPPPSSALFRRKTLPFFERHSLPISASSSSSSSSSTSLSVHEKPISNSVHFHGNLIESFENQDSSYAGTIKGASLIEELENPVERNGLSGRRRLFMQDPPWISALFLKGLSKMVDQTLKIERKDIDKRKFDSLRRRQVKEETEAWERMVDEYRDLEKEMCEKNLAPNLPYVKHMFLGWFQPLKDVIEREQKLQKNKSKKVRAAYAPHIELLPADKMAVIVMHKMMGLVMSGHEDGCIQVVQAAVSIGIAIEQEVRIHNFLKRTRKNNAGDSQEELKEKQLLRKRVNSLIRR... | 119 |
Q80X41 | 2.7.11.1 | ACT_SITE 177; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPRVKAAQAGRPGPAKRRLAEQFAAGEVLTDMSRKEWKLGLPIGQGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSHKNPDQVYLVDYGLAYRYCPDGVHKEYKEDPKRCHDGTLEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRDSKIRYRDNVAALMEKCFPEKNKPGEIAKYMESVKLLEYTEKPLYQNL... | 99 |
A0A9R1VF11 | 3.1.1.11 | ACT_SITE 405; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHALKSPLMASSLYICTPFLILALFLSPTSSAVVPSANSSVCQYTRYPSFCRSSLPINNSSANVYDYGRFSVRKSISAAHKFSSLIDKYLSGSSGLTTGAIHALQDCQYLAGVNIDFLTNAFQTVDKSQTTLSTMKSQDIQTMLSAILTNTQTCIDGLQATAASWSSKNGILAPLANDNKLYSVSLSLFNRGWGVKNKKKSSSVSAHKKHIGFKNGRLPLKMSERSKAIFETVGRRKLLQTDDGGDQVVVSDIVVVSQDGTGNFTTVTDAINIAPNKSAAADGYFLIYVTAGVYEEYVNIPKNKLYLMMIGDGINQTVIT... | 125 |
Q10925 | 2.7.10.2 | ACT_SITE 230; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MASTSGALVDDNVLEVLRKAQLDAFISQFVFLFNVRRFDHFSHVRDKDMLEIGMQQVQIRQLREQILKMSREMWNRSDPKQVYIQADQSMPAQNSIDEKALIPNEQIKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIVRQPAMMVFELCEGGSLLDRLRDDKKAILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLK... | 98 |
A0A2K3DH08 | 1.8.1.9 | ACT_SITE 478; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAAAGAPAEGASAYEYDLVVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPAGTSWGLGGTCVNVGCIPKKLMHNAGLLGEGFSDARGYGWKLPEKIEMNWEDLVMGVQNHIGSLNWGYRVALREASVKYLNAKGSFVDAHTVEAVERNGTKHTLTAERVVIAVGGRPKYLGVPGDKELCITSDDIFSRATPPGKTLVVGASYIALECAGFLRALGYEVAVMARSIFLRGFDQEIAELIGKDMERRGVRMIKPAVPTAFERDGEQIKCTFKNLDFGVEMSESFDTVLLAVGRDACTFDLGLEKVGVTYDKSSGKIPVTAE... | 37 |
A0A9R1V0K3 | 3.4.19.9 | ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 313; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MKPPQPPPLPPPCSVTVVTEHSSSSSSSPSISPATTSDMWNYIWIPFLLSLMKEVSSANAASESKIFLPSASVAGLTSSCPAPDPKLNYRPIIGILSHPGDGASGRLNNATNASYIAASYVKFVESAGARVIPLIYNEPSEVLQSITCSIALQKLNLVNGVIFTGGWAKTGLYLDVVDRIFKQVLKKNDAGDHFPLLAICLGFELLTMIVSKNNDILEGFSASDQASTLQFIKNINVEGTLFQRFPPELLAKMSTECLVMQNHKFGISPETFQGNMELCSFFKILTTSVDENNEVYVSTVQSKSYPVTAVQWHPEKNAFE... | 176 |
A0A644F5R3 | 2.3.2.26 | ACT_SITE 674; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MHDGIPLGPREVATTIAMPLFPVIAVITVSMASLLIHQKPILFLCICSPIASVLLLISWLFCIISGKYGIGVSYIVVTLTTLPSLFGISWKPHRWLVAIVSYSVSCFLCLVFLFIIPFYARVYHTVVLILGILIPYVLFALSHALSLFILLRWYRHFTQRLTEQLNGISLEGKTEIIAYRYLPAPRVYPLSDSTVALWTTQEMIRQKVYGFRLCALFSRVTNLPYFAQTTVNSLKYALSFSRTDDESVELYGEGLREKTLTCLCRLKMVIGVKEITASAHFSSETYTIEPLSLSKILSIASASSILSHSPTENLFLRAFN... | 65 |
A0A8V1ALE8 | 3.1.3.3 | ACT_SITE 41; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 43; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MSPAPDTSLRAARGGKKVPRRMASLLEMKEIFRNADAVCFDVDSTVIREEGIDELAKFCGVGDAVAEMTRRAMGGTVTFKAALTARLGLIRPSYEQVQKLISDNPPQLTPGIRELVNRLHQRGVQVFLVSGGFQSIVEHVALQLNIPTANVFANRLKFYFNGEYAGFDETQPTAESGGKGKVITHLKEQFHFKKVVMIGDGATDMEACPPADCFIGFGGNVIRKQVKEKAKWYITHFDELLKELEER | 147 |
D7TFI5 | 3.4.19.12 | ACT_SITE 93; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 96; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR013503-1" | MENEEGLQADGESDPKAPIPVSEVDAWENIRDDDIMQQQSAIRAEEAEKVPFIGDKEPLSVLAAEYESGSPILLKKIKVLGEKYGSIRRTRGDGNCFFRGFMFSYLEHILESQDQAEVDRVTTNVEKCRETLQALGYADFTFEDFFALFLEQLESVVQGKETSISHDELVIRSRDQSISDYIVMFFRFVTSGEIKRRSEFFEPFILGMTNATATVEQFCKSSVEPMGEESDHVHIIALSDALGVPIRVVYLDRSTYDIDHVIVNHHDFIPSAGDLPSAGGGSSETTKPIVTLLYRPGHYDILYLK | 175 |
Q5A5S6 | 1.1.1.37 | ACT_SITE 184; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MVKVTVAGAAGGIGQPLSLLLKLNPNVDELALFDIVNAKGVAADLSHINTPAVVTGHQPANKEDKTAITEALQGTDLVIIPAGVPRKPGMTRADLFNINASIIRDLVANIARVAPTAAILIISNPVNATVPIAAEVLKKLGVFNPRKLFGVTTLDSVRAETFLGELTNTDPTKLKGKISVIGGHSGDTIVPLINYDAGVGVLSDSDYKNFVHRVQFGGDEVVKAKNGAGSATLSMAYAGYRFADYVISSLTGGATPAGRIPDSSYIYLPGVSGGKEFSAKYVDGVDFFSVPVVLSQGEIRSFVNPFEELTVTKEEKKLVE... | 5 |
A0A061FE40 | 4.1.1.17 | ACT_SITE 390; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MPSYLFRHLRSIWKYMHSLIVSPFLSLDQSRTMVSSSRSLQAIISAGWLTRKRAAALSENELIAFIQSVISDEQQTEPFYVLDLGVVVDLFDTWIRNLPMVQAFYAVKCNPSPALLREMAALGSNFDCASRAEIEAILALGVSPDRIVFANPCKAESHIKYAASVGVNLTTFDSKDELEKIRKWHPECALLIRIKPPETSGARFQLGAKFGALPEEVVPLLQAAQAAKFTVPGVSFHIGSGATHFRAFEEAIAAAKTVFEKAAHLGMPNMHLLNIGGGFTAGPRFTEAAPVVKTALQKYFFNEPGLKVMAEPGLFFAQSS... | 195 |
A0A061EQ27 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVMRTIVAVFFLLHFRFGVKGCSLSYDFYEISCPQVEDIVKDGLQAMFLTDPTSPAALLRLMFHDCQVQGCDASILVDPGEGSVPTEMASAKNFGIRKRELISILKSMVEAQCPQQVSCADILILAAREAVALTGGPRIQVPLGRRDSSQTLSYELADTVLPPATAGVADMLNIFAEKGMTLAESVAILGAHTLGITHCSNIQNRLYSSNNGELRAMEPGFASFLRLTCPRGPLTSNLSFVLNDPTTFVFDNEYYVNAMGGWGVLKIDAEMALDPQTAHVMQRFSINQDDFFQEF | 14 |
Q0JDC5 | 3.2.1.26 | ACT_SITE 69; /evidence="ECO:0000255|PROSITE-ProRule:PRU10067" | MGVLGSRVAWAWLVQLLLLQQLAGASHVVYDDLELQAAATTADGVPPSIVDSELRTGYHFQPPKNWINDPNAPMYYKGWYHLFYQYNPKGAVWGNIVWAHSVSRDLINWVALKPAIEPSIRADKYGCWSGSATMMADGTPVIMYTGVNRPDVNYQVQNVALPRNGSDPLLREWVKPGHNPVIVPEGGINATQFRDPTTAWRGADGHWRLLVGSLAGQSRGVAYVYRSRDFRRWTRAAQPLHSAPTGMWECPDFYPVTADGRREGVDTSSAVVDAAASARVKYVLKNSLDLRRYDYYTVGTYDRKAERYVPDDPAGDEHHI... | 164 |
Q59H18 | 2.7.11.1 | ACT_SITE 588; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID... | 99 |
H2LB91 | 3.1.3.48 | ACT_SITE 213; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000926-1" | MEEEFQDIDSSAGWQNLYNEIRNLASEHPYKVAKLPENKNLNRYRDVSPYDHSRVTLKDSENDYINASLVTEEEAQRSYILSQGPLCYTCGHFWLMIWEQRSKAVIMLNRVIEKGSEKCAQYWPTKEESQMSFTDTGFVVKLLSEEDQSYFTVRVLELHNTKTMERREIYHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSTDHGPPVVHCSAGIGRSGTFALVDTCLVLMDKRKNPSSVDIQKVLLDMRKYRMGLIQTADQLRFSYMAVIEGAKLILKDDCTSQESMLKNFLKKELKPELAPPPPPPRPNLNDNRPN... | 149 |
B9HIK0 | 2.3.2.26 | ACT_SITE 1001; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFFNGDSSTRKRVDLGGRSSKERDRKKLLEQTRLERNSRLWVKQQNAAAVKIQKWFRGRKAVEAEHSRVRGKFHGTYGKCCQNVDRHCFGPDSEFFRQLLFFFNAKDSDDFTILVETCRLLLQNVQDSGDIVSLFAGGDYSTKHALVEYRVKKLSFACIWAIYQNRKQLKDQLVMMPRDSSITATLLLEAVALLIDPKLPWACKVVGYLLQRNVFALFREIVLTGKENMRSDSSIRNASPLERILALVISHVGQKPCICPTIDLQWSFSSQMLTIPLLWRLFPNLKEVFATQGLSRHYINQMARCMRNNTYVLPNDLSVE... | 65 |
A7EMR3 | 2.7.7.7 | ACT_SITE 542; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MSDKASFFEQLYALNQSDSDDGMPNESREFWKKCNKPILDAPSQKVQSLLPPRSKEFNTLPPRKVYKPLLKNVPSLQRSQSEPQGNVTKAKNMVNGTATAELSIESPRKRSGLRSESRATVSASSSFEKEISSSIRSADGSTKRPTIDQCSISNPTPAKLVLTNSTGIASMLSKKRKGETLNKGTAKKATGKKEKPLKLVPPKDRVFEGLKFFFLPNDDKSPVRRARITKARERGATWVRDINEPINYLIIDRSLTRKDVITYLKVLPVGASMVNEEWLLDCIEQKYLYDPSGKKYLVKDPGAVIEKEQILVPSESQQSD... | 121 |
A7SYX6 | 3.2.2.27 | ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MQTGQSKISSFFGKPATKRKADETENASKYPPSKFAKEKDKSDSDEADNKSPISLSPEQKARMNQKRMEAEEKLLANTGPRNFGLSWKKALKEEFTKDYFERLMKFVESERAKKTVYPPEKDVFSFTLHTDIKDTKVVIIGQDPYHGLNQAHGLCFSVQPGVSVPPSLVNIYKELSNDIDGFKHPGHGYLIGWAKQGVLLLNACLTVVASQANSHKEKGWEQFTDAVIRWINRNLSGVVFLLWGSYAQKKGSFIDKKKHCILKAVHPSPLSAHRGFLGCKHFSKANEYLIQRGKKPIEWANLPIEVDG | 173 |
Q9Z0J5 | 1.8.1.9 | ACT_SITE 499; /note="Proton acceptor"; /evidence="ECO:0000250" | MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGR... | 37 |
P00760 | 3.4.21.4 | ACT_SITE 63; /note="Charge relay system"; ACT_SITE 107; /note="Charge relay system"; ACT_SITE 200; /note="Charge relay system" | MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN | 177 |
Q7M370 | 3.1.1.3 | ACT_SITE 188; /evidence="ECO:0000255|PROSITE-ProRule:PRU10038, ECO:0000269|PubMed:9665742"; ACT_SITE 342; /evidence="ECO:0000250|UniProtKB:Q5NUF3"; ACT_SITE 372; /evidence="ECO:0000250|UniProtKB:Q5NUF3" | GVKTVLLLIVGVLGAYYVYTPLPDNIEEPWRLLWVNAHMKTLTNLALFAEYLGSNIFMNTVKFLTSFQEVPPTSDENVTVTETTFNNVPVRVYVPKRKSKTLRRGLFYIHGGGWCVGSAALSGYDLLSRRTADRLDVVVVSTNYRLAPEYHFPIQFEDVYDALKWFLRQDVLEKYGVDPERVGVSGDSAGGNLAAAVAQQLIKDPDVKIKLKTQSLIYPALQTLDMDLPSYRENAQFPILSKSFMVRLWSEYFTSDRSLEKAMLLNQHVPVESSHLFKFTNWSSLLPEKFKKGHVYNTPTYGSSELARKYPGFLDVRAAP... | 128 |
A0A2K1IE08 | 2.3.2.26 | ACT_SITE 1370; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MIMGTTQNVPSVARGGQLSLGGANVKELTRDELASRVAQERVIRSLGKQAATSALLIQRVWRGRTVARQAAAQARAEWDEQFLTRFGENQTMFSAATISNNLLRPLFMILRHSSCFDSNQTHERAENMGRLAICFRILLQSIHNPDMHYNYCDLSVGFPDKMFKWMYQARQLLRLACAALEKEGIGSRESEPNGMDKNCMTLEASNLAGLAMRVTIALTDSSTWKCFDEPRQEVRKGKAKLVALDLLEWLANGNGGLFLAVRSYILANFPVPGIMDENPRPRGKKDKFIITASIITITLRPLLILAEECNKDSDREALQD... | 65 |
P53894 | 2.7.11.1 | ACT_SITE 475; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MYNSSTNHHEGAPTSGHGYYMSQQQDQQHQQQQQYANEMNPYQQIPRPPAAGFSSNYMKEQGSHQSLQEHLQRETGNLGSGFTDVPALNYPATPPPHNNYAASNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLSPGQYSIESEYNQNLNGSSSSSPFHQPQTLRSNGSYSSGLRSVKSFQRLQQEQENVQVQQQLSQAQQQNSRQQQQQLQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPVQSGFNNGTISNYMYFERRPDLLTKGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTSHNW... | 99 |
Q8ZV53 | 2.7.1.21 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MLVVIVGPMFAGKTTELIRRVERYVIAGRRAIVFKPSLDVRYDASKVAAHNGLKFDAFVIPPDKDGVEIIRKMGAEYDVVAVDEIQFFPVDLADALNQLANGRIVIAAGLNLDFRGEPFETTARAMAFADRVISLSAVCKLCGKPATRTQRLINGVPAPRHSPRILIGGNESYEARCRRHYVIPP | 88 |
Q81GG4 | 4.2.1.20 | ACT_SITE 47; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 58; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MGVEKIKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTLKGIFQALAEVRKEVQMPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIAPLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICELIYATKQKEEA | 202 |
Q5AUW5 | 3.2.1.21 | ACT_SITE 324; /evidence="ECO:0000250" | MRVPSLSVLSFLLGTALAAASNFEAGLLSSGKVSLGDWKSAHEKASQFVAKLNTTEKIKLITGSSVTTTNGETFTALDILDGDMGAQAYYYVSAFSLSSALAMTWDKEAMYEQGRAIAAEFYGKGIQMVAGPTSQPLGRTPWGGRLVESFGPDPYLNGIATGLETRAYADVGVIAGAKHFILNEQETNRTGGMGGGGGAPGGGGMGRGAEFSSSVPGGMSPTSSAGAIPSSTSTPGGSGMGGGMAGSSAFSSSSSSGAPYSSNADDKTLHETYLWSFYDAVHSGLGGVMCAMTKVNGTLSCQSSSLLLDILKTELGFPGM... | 161 |
A0A1S4GVQ5 | 2.7.1.11 | ACT_SITE 168; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSSAPVQRFIQFGAHKGKGIAVFTSGGDSQGMNAAVRAVVRMGIYVGCKVYFIREGYQGMVDGGDNIVEANWSSVSSIIHRGGTVIGSARCKDFRERAGRLQAAHNLVSRGITNLVVIGGDGSLTGANLFRQEWGSLLDELLASNRITQDQRIKYKSLHIAGMVGSIDNDFCGTDMTIGTDSALHRIIEAIDAIVSTAYSHQRTFIMEVMGRHCGYLAVVAGLCVEADYIFIPEDPPKPDWPERLCKQLTQERSAGQRLNIIIVSEGAIDRDGNPITAEKVKQVVVDRLQQDTRITVLGHVQRGGNPSAFDRVLGCRMGA... | 84 |
Q83DJ2 | 3.4.21.92 | ACT_SITE 99; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 124; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MSVLVPMVVEQTSRGERAYDIYSRLLKDRVIFLVGQVEDHMANLAIAQMLFLESENPNKDINLYINSPGGAVTSAMAIYDTMQFVKPDVRTLCIGQAASAGALLLAGGAKGKRHCLPHSSVMIHQVLGGYQGQGTDIQIHAKQTQRVSDQLNQILAKHTGKDIERVEKDTNRDYFLTPEEAVEYGLIDSIFKERP | 179 |
A0A3B6C5E9 | 1.3.5.1 | ACT_SITE 266; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MWRGCVSRGLSKAKASASRLFSTTSSSYTVVDHSYDAVVVGAGGAGLRAAIGLSEHGFSTACITKLFPTRSHTVAAQGGINAALGNMSEDDWRWHMYDTVKGSDWLGGQAYRCACAADRTGHAMLHTLYGQAMKHNTQFFVEYFALDLLMDNEGNCQGVIALNMEDGTLHRFRATNTILATGSGYGRAYFSATSAHTCTGDGNAMVARAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGILRNSEGERFMERYAPTAKDLASRDVVSRSMTMEIREGRGVGPLKDHIYLHLNHLPPEVLKERLPGISETAAIFAGVD... | 28 |
Q9HUM6 | 6.3.4.4 | ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MGKNVVVLGTQWGDEGKGKIVDLLTEQAAAVVRYQGGHNAGHTLVIDGEKTVLHLIPSGILREGVQCLIGNGVVLAPDALLREITKLEEKGVPVRERLRISPSCPLILSYHVALDQAREKARGEAKIGTTGRGIGPAYEDKVARRGLRVGDLFHRERFAAKLGELLDYHNFVLQHYYKEPAIDFQKTLDEAMEYAELLKPMMADVAATLHDLRKHGKDIMFEGAQGSLLDIDHGTYPYVTSSNTTAGGTATGSGFGPLYLDYVLGITKAYTTRVGSGPFPTELFDDVGAYLAKRGHEFGATTGRARRCGWFDAVILRRAI... | 253 |
A0A3N7FCA2 | 1.11.1.7 | ACT_SITE 121; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSTSIFGIGNMRKLSLLVLILCILISVKNQNAEIKKSSSSSKTAVKWPYSSWDSFPSVFLSPLTSMEDDDGEVSWHSNRSLEYDFYRDSCPEAERIIRRVVHELYEVNSSVAPALLRLVFHDCFIEGCDASILLDAATGIDSEKDSPPNKNLKGFDIIDKIKSEIEMVCPGVVSCADIVALAGREGVVQAGGPFYPLYTGRRDAMHSFRDVATSELPSPNADLSETLASFASRGFDLRETVSLLGGHSIGVIHCKFFQNRLYNFGRTNKPDPSLDTGFLNLLRSRCNDSNSSMAASPSPSPSFKATPPAPSTSCDGTNSP... | 14 |
P56634 | 3.2.1.1 | ACT_SITE 185; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:9600843"; ACT_SITE 222; /note="Proton donor"; /evidence="ECO:0000305|PubMed:9600843" | QKDANFASGRNSIVHLFEWKWNDIADECERFLQPQGFGGVQISPPNEYLVADGRPWWERYQPVSYIINTRSGDESAFTDMTRRCNDAGVRIYVDAVINHMTGMNGVGTSGSSADHDGMNYPAVPYGSGDFHSPCEVNNYQDADNVRNCELVGLRDLNQGSDYVRGVLIDYMNHMIDLGVAGFRVDAAKHMSPGDLSVIFSGLKNLNTDYGFADGARPFIYQEVIDLGGEAISKNEYTGFGCVLEFQFGVSLGNAFQGGNQLKNLANWGPEWGLLEGLDAVVFVDNHDNQRTGGSQILTYKNPKPYKMAIAFMLAHPYGTT... | 157 |
A0A2R6XAN4 | 2.1.1.33 | ACT_SITE 195; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MADCEDGGFKGKRRSEQQTLAQGGNQKGLPRKRFYRARAHSNPLSDSYFPVPNNPSDCDWKEHFPAFFKDNASEVESGKPANDEAKSEVRSSESGAVVPSFPAEKSVPKVRFADIGCGFGGLLVKLSVLYPDKLMVGMELRDKVSEYVKERILALRLKYSGQYENISCLRTNAMKYLPNYFEKGQLEKMFFLFPDPHFKEKNHRRRIISQALLAEYAYIMAIGGIIYTITDVEELGEWMKSNLDAHPLFEPLSEAELAKDPVVDLLTSATEEGQKVARNSGETYRAIYRRIASAV | 45 |
G7J5Q2 | 3.4.21.89 | ACT_SITE 221; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 271; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MAIRVTFSFSGYVAQNLVSSAGVRVANSRCVQECCILSRLFGSNPKPDLERSGGFRNRNLYSDFTKPRNSPVSVYSTLAGEILSESCNNPIILGLISMMKSTAISGSTSAAMGAMGISPFKTSSIIPFLQGSKWLPCNESVPTATTWEVDKGGTRIQSQPVSVSSDKESRLDLNQKENTNGWISKLLNVCSEDAKAVFTAVTVSLLFKSFLAEPKSIPSASMYPTLEVGDRVLTEKFSFFFRKPDVSDIVIFKAPSWLKAYGFSSSDVFIKRVVAKAGDVVEVRDGKLLVNGVAEDEEFVLEPLAYELAPMVVPKGHVFV... | 178 |
O67919 | 2.3.1.286 | ACT_SITE 107; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAKAQPNEGHKILTKMEEEFPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGNERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALSRAYELSREAHVFIVVGTSGVVYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG | 58 |
V5IRA9 | 5.1.3.15 | ACT_SITE 207; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 317; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MVDRGRKPSALASTPGLPPQPQVAFSSDNSRVTATLPTGESVSVLLYGATVVSWKDKNGHEKLWLSEAAKLDGSKPVRGGIPLVFPVFGTAPDHAQTKDLPQHGFARSSRWEFLGKSTSESTPTPTTPAFAATATSAAGAVAAAAADLSVKLDFGLSSSGLSEDARAKWPYAFNAIYSVTLNTDSLTTNLVITNDDERSWECQMLMHTYLRVNDITSVSIHGLENASYVDKTTSPISTSTQTTSALTISSETDRVYTPAGDDPASIPITVFEGDQPKYTVLRDNLANVVVWNPWIEKAQGMADFEPKDGYKNMLCVEPGA... | 210 |
A0A3B3H7Q0 | 4.6.1.16 | ACT_SITE 305; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 313; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 352; /evidence="ECO:0000256|PIRSR:PIRSR011789-1" | MQADFRAPRRRARVYEELEAPLPVIRSAGEKCVYRAELINQHVLVCHPDHVRKIHNQGYFGKGILSRARPDHSISEKWEDFEDLYLPVVSQARYEELLGWAKASLCAQGMSAEAVDQIFHKLTQKLEIEDVKSELREAEGAKTEDGVCDNTKSLGRESEAEPEAKRPCRSDIQDLNFDQNSEPSFDSDQDSEPDLGFQVPGPGFVLVVSENQNEGGVREVKRSPLSLTEYLQLSLEEAFFLVYSLGCLSVYLDQEPQSVIQLWRRFRSLRPDFTSSYAAYHHFRSRGWVPKGGSGAKYGVDFMLYRKGPPFYHASYSVVV... | 207 |
P54678 | 7.2.2.10 | ACT_SITE 385; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250" | MTGSHEMESIMLDSMEEEFPVSVETLGKLVDVPKGFDTYAELGGLSGLSTKLKSNIKTGLPLEKSSTEENRVLKYSKNILPDPPHQPLWSIVLDALSDHILILLIVAAVVSIVLGSIDYTSDHPETGWIDGVAILVAVILVVGITSLNDFKNQARFRELNDKSNDKEVKGIRGGEQCQISIFDVKVGDIISLDTGDIICADGVFIEGHALKCDESSITGESDPIKKGQPQDNMDPFLISGSMVIEGFGTMLVTAVGVNSFNGKTMMGLRVASEDTPLQMKLSVLASRIGYFGMGAAILMLLIAIPKYFIQRKVHDIEITR... | 258 |
P29461 | 3.1.3.48 | ACT_SITE 666; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MDRIAQQYRNGKRDNNGNRMASSAISEKGHIQVNQTRTPGQMPVYRGETINLSNLPQNQIKPCKDLDDVNIRRNNSNRHSKILLLDLCAGPNTNSFLGNTNAKDITVLSLPLPSTLVKRSNYPFENLLKNYLGSDEKYIEFTKIIKDYDIFIFSDSFSRISSCLKTTFCLIEKFKKFICHFFPSPYLKFFLLEGSLNDSKAPSLGKNKKNCILPKLDLNLNVNLTSRSTLNLRINIPPPNDSNKIFLQSLKKDLIHYSPNSLQKFFQFNMPADLAPNDTILPNWLKFCSVKENEKVILKKLFNNFETLENFEMQRLEKCL... | 149 |
A9V8S4 | 4.1.1.17 | ACT_SITE 432; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MLQRLHLLRLQLATPTRLPRTNVMLPPPPPLPKPIGQSATHAIACEGHGHQAQRQALRQIIRQQACNSSSPDRGTDLNLLVNKAPTCQSRTAEPTEDDDDTDRAIFLLDLAQVVRQQRRFERQLPNVQPFYAVKCNPDPHILRALDALGVNFDCASKGEMAQVLDMGVAPERIIFANPCKPISHLRAARRWGVQLMTFDNEDELDKIHVHYPEAQLVLRVLADDSSAVCRLGLKFGAPLSVVPRLLRRALELDLNLVGVSFHVGSGCTDANAFADAVHRARQVFDMATELGVCLKILDVGGGFPGADETSTNSKDVTFAD... | 195 |
Q8EIX3 | 2.7.11.1 | ACT_SITE 306; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P23874" | MSTAKTLTLEMHLGDLMIGELSFDATADTFAVHYTKDWQQSGFPLSPTIPLDGTGTSNQISMFLVNLLPENKGLDYLIESLGVSKGNTFALIRAIGLDTAGAIAFVPKGALLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYNGKEFAFAEGTLSSTHIVKFEKYHHLVINEFITMRLAKVLGMNVANVDIVHFGRYKALCVERFDRRNIPGEQRVLRRHIVDSCQALGFSVSKKYERNFGTGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG... | 99 |
B9S0A6 | 3.1.1.11 | ACT_SITE 226; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGIRPLSFWLLASAIALLSILLSLYAIPSSPSTNASVSIQDAFQLAILKRVIKKSGLQEVLQLILSRHHHHRRRPKVKCDKNSWSIQKAIDVVPDFSPSPTLIIIDSGTYREKVVVHTSKTNIILQGQSYMNTAIEWNDTANSTGGTVYSASVAIFAPNFTAYNISFKNTAPNPSPGEVGGQAVAIRVGGDQAAFYGCGFYGAQDTLNDDHGRHYFKECYIQGSIDFIFGNARSLFEGCIINSIAKPTRGGVSGSITAQARQSMSEQTGFSFVSCSIRGTGKVWLGRAWGAYATVVFSKTYMSNAISSDGWNDWRDPSRD... | 125 |
A0A1B6P8N6 | 3.2.1.52 | ACT_SITE 326; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MASPALRLRLRLLLLLAVAATATARGAGAGRVDLWPMPASVARGAQTLLVSKDLKLSTAGSSYADGKGILKEAFQRMLAVVELDHAINGTYSSHGAPVLAGVRVAVRSPNDELNFGVDESYKLSVPATGNPLYAQIEAQTVYGALHALETFSQLCNFDFNANLIELQSAPWTILDAPRFPYRGLLIDTSRHYLPVPVIKSVIDSMTFSKLNVLHWHIVDEQSFPLQIPSYPKLWNGAYSYSERYTFDDAIDIVQYAEKRGVNVLAEIDVPGHALSWGVGYPSLWPSATCKEPLDVSNEFTFQVINGILSDFSKIFKFKFV... | 170 |
I1IMN1 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGSSRASTTMALLLLVLGAIVSVSQGQLQVGFYSSSCPGAESTVASAVRSASASDSTILPALLRLQFHDCFVRGCDASVLIKGGNNNAEVDNGKHQGLRGLDVIDSAKAQLESQCPGVVSCADIVVLAARDAVAFTGGPSFDVPTGRRDSKVSNLRDADVLPDVKDSAQVLRSKFAAAGLDHKDLVLLSAAHTVGTTACFFIQDRLYNTPLPGGGRGSDPSIPDAFLSELKSRCAPGDFNTRLALDRGSERVFDTSILRNIRNGYAVIASDAALYNDTATVDVVDSYSGLLSAVFGPYFRPDFADAMVKMGSIGVLTGSQ... | 14 |
A0A8I6G1H3 | 2.7.11.1 | ACT_SITE 313; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038189-1" | MSKPLTPSTYVRSLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLIQIELFAPATLLLPDAVPQAVHSLPPREAATVAQAHRPCQEKNRTTVTPALAQKLEPSCELPDSSSPGHQSVEFSDTRFHSFSFYELKSITNDFDERPVSIGGNRMGEGGFGVVYKGCVNNTTVAVKKLGAMVEISTEELKQQFDQEIKVMAKCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHMRCKIARGAANGIRFLHENHHIHRDIKSANIL... | 99 |
Q1ZXF2 | 2.7.7.7 | ACT_SITE 116; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MDYKIKNKKRERSSDDDDENSSGNEKIVNKKQHKIETITKPTKPLSTLAVSTGCNKNQKLTDIITELSIFEKNKGLQHKYSAYRKAAQSIRAHPKEITSGIEAQKLDGVGKKIAKKIQEIIDTGELKKLNNQLKDETLTSIGEISKVSGIGPKAAQKFYDEGIKSIKDLWKIKDRLTHHQQIGLKYFNEIEQKVPRNEIEQFEELVRQALLKIDKKIIYETCGSYRRGLPSSGDVDILLSHPNYTLKMKDKKETFHIVEKLVDSLKKSGIIIDDLSLGPFKYMGICKLPSNIKLDNIDCKKEKNDHYSDNDDDEKEEEGN... | 121 |
A0A5F8GYE2 | 3.1.4.11 | ACT_SITE 174; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 221; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MLTLQVNREGRFPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLLDFVNQKQRDPRLNEVLYPPLRPAQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENSVLPPEALDLSNDMTQPLSSYFINSSHNTYLTAGQLAGASSVEMYRQTLLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPFPVILSFENHVDSAKQQAKMAEYCRTIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPPLSPS... | 153 |
A2FGM6 | 3.1.3.16 | ACT_SITE 258; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MITRPPTPIFSNQILTEISDSSIDGELSQLYSDRAEVFYNLNKIKEAKGDLTSALELDKTNSKAILLQHKIHIKERDTDAAFRDFLFYPTLKEANPTDFKRYLQFHERIAKFAEKINNVTVDLKPKSKVSEGECDFEHFTREDAIDMTKYLRDFNRPKAETVIALIDKIKAILKPLPNIVSINPSSTTGKIRVVGDTHGQFQDLCYIFDQFGYPSADNPYLFNGDYVDRGSMGVEILLTLLCWKVAEPNSIYLNRGNHEAISMNGLYGFERECTVKYSAEMFRRFSDLFCYLPVGHIIGGKVLVVHGGLFGDDATTIQTI... | 144 |
P38627 | 6.3.4.2 | ACT_SITE 404; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 537; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 539; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605" | MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGITLSRDHNITTGKIYSHVISRERRGDYLGKTVQIVPHLTNAIQDWIQRVSKIPVDDTGLEPDVCIIELGGTVGDIESAPFVEALRQFQFEVGRENFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLIPDMIACRCSEELNRSTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQHMIDYLHSRLKLGEVPLTLEDKERGSQLLTNWENMTKNLDDSDDVVKIALVGKYTNLKDSYL... | 252 |
P0A7E5 | 6.3.4.2 | ACT_SITE 379; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000305|PubMed:11336655, ECO:0000305|PubMed:15157079"; ACT_SITE 515; /evidence="ECO:0000305|PubMed:15157079"; ACT_SITE 517; /evidence="ECO:0000305|PubMed:15157079" | MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNR... | 252 |
O61722 | 3.1.3.48 | ACT_SITE 109; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MSITMRQKDLRPAPALIEYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPKARLKHKNGHKNSCSVQ | 149 |
Q8DNA2 | 2.2.1.1 | ACT_SITE 408; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLHINPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMDEIKSFRQWGSKTPGHPEFGHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEGVSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGTDLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALGWDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEAHPE... | 51 |
A0A9R0J2C8 | 3.5.1.2 | ACT_SITE 78; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 201; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 203; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MAIGVLAFQGSFNEHIAVLRRIGVKGVEIRKPEQLQNVAALIIPGGESTTMAKLAEFHNMFPALREFVKMGKPVWGTCAGLIFLANKVVGQKAGGQELVGGLDCTVHRNFFGSQIQSFEAEISVPHIADKEGGPPGFRGVFIRAPAILEVGPEVDVLAEVPVPDKVKNSDIAKEIQEVNPECLNKVAVAVKQGNLLGTAFHPELTADSRWHMYFVKMVNDQSEEAKIETETETETSSNIIKSGDSSALQDPKIELPIYLP | 181 |
Q9VV00 | 3.4.19.9 | ACT_SITE 136; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 247; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 247; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MAESAYTDAPYLNRVPTVGVMCIDIATQLQQNFSGAYHSYLAASYVKFLEASGAHVVPIWIGRERAYYALMMSQLNGILLPGGAVFIDEADRQANPDVTSDCVRSAELIYQLAMERNMRAKKLDDRGAYFPVWGTCLGFQLILIHAAEAPNVRIACQPMREAMPVTLTDDYQQSQLLGSLPKSVADEMEKHPFACHQHRYCITKESLESYGLAKDWHPLATQKDTSGLEFITIVEHRRFPIFGCQFHPERAAFEQLFNSPDKCYMAHSRMGIDLSQIFGSRFVDFCRRNNNQFESDKLKTRHLIWNWQPVFSGKFKGSNW... | 176 |
B9N4L3 | 3.1.1.11 | ACT_SITE 414; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSYGDDSNRKRRIAVIGISSFLLVAMVVAVSVGVGLGNDGNEDLNDSNHKSTNQVSASMKAVKAICQPTDYRKTCEENLQKAAGNTTDPRELIKMAFKIAEKHVNEASKKSKVLEELSKDPRTRGALQSCRELMTMSVDELKQSLNKVTDFDITEIEKLMADVKTWLSASITYQETCLDGFQNTTTNAGKEMKKGLKLSMELSANLLAIVSGISSAIPSLESLGQRRLLQDDLPVLGHGDQIFPTWTDFGKRRLLAAPASKIKADIVVAKDGSGDFSTIRDALHHVPIKSSKTFVLYIKAGIYQEYIDFNKSMTNLMVIG... | 125 |
P0AF24 | 3.1.3.5 | ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:16430214"; ACT_SITE 11; /note="Proton donor/acceptor"; /evidence="ECO:0000305|PubMed:16430214" | MTIKNVICDIDGVLMHDNVAVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAGVDVPDSVFYTSAMATADFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAYFVANGARFIATNPDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDSMPFRPSWIYPSVAEIDVI | 150 |
D8SVH8 | 5.3.1.8 | ACT_SITE 287; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MIRLQCQVQHYEWGRIGEESEVGRLHALMTGSAVDADVPYAELWMGTHASGPSTVLRRGGAGQILLKDWLQRHPEALGDRVLERWNGDLPFLFKVLSVAKALSIQAHPDKKLAEYLHGKNPQVYKDANHKPELALALTRFGALCGFVTSQELQAALESVPELRDALGPLVVESVIRSGCGQSAKDVLRRAFTCLMTLDESVVTHTLSNLIDRLKRKSKAAGGLSPKEELVVSLEKQYPGDVGVLSAFFLNYTNLEAGQAVFLDANEPHAYLYGECVECMATSDNVVRAGLTPKFRDTQTLCSMLSYNQASKTILDGCYVN... | 214 |
A0A1Y1I619 | 1.11.1.6 | ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 165; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MAVGSSNGSANGAAPNGAHVKGMSDGAASADNPRVGSDGKTPLLTTGGGHPVSDDNNSVSIGGRGQLLLEDFHLLDKLAHFDRERIPERVVHANGSGAHGYFEVTQDVSDLCKAAFLSEVGKRIPVLSRFSTVGLESGSADTVRDPRGFSVKFYTEEGIWDMVGNNTPIFFMRDPIKFPDFIHTQKRHPSKHVKDPDVFWDFLTLTPESFHQVLILFSPRGVPDGYRHMNGYGSHTFKWVNKEGQANWVKFHFKTDQGIKNLTHEEGVKLAGIDPDYAKKDLYNSIEAGDFPSWTFFVQVMSLEQAETFKWDPFDLTKVW... | 13 |
A0A6I8P9I1 | 2.5.1.18 | ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MAPRPCELFYDVVSPYSWLGFEVLCRYRNTWNINLRLRPSFIAGIMKDSGNKPPALVPRKGKYMTQDLKRLSDYFQVPLHMPKDFARSVLEKGSLSAMRFLTAVNMERPELLEPVSRELWMRIWSRDEDITEAQSILAAATRAGLTPEQGQELLRKIDSPEVKERLKVTTDAACNYGAFGLPVVVAHVGGQPHMFFGSDRLELLSHLL | 77 |
D8S1M4 | 4.1.1.17 | ACT_SITE 333; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MDSFIRKKIQSTGREDAFYVLDLATVTRLWKIWKSAMPRVHPFYAVKCNPDPQLLSMLAALGAGFDVASKAELEAVTQLGVAPRNIIFANPCKLPSHITEAAKAGVVYTTFDSEGELYKLKKYHPQAEVLLRFRADDTGARCPLGVKYGAEWDECYHLLEVAKTLGIKVAGVAFHVGSGASDVNAFAEGIKAARKLFDMAESLGLPRMTMLDIGGGFVSDGGAGVKFAAAAYEIGNALEEHFPRETMADVRIIGEPGRFFAEEAFSLAVLVFGCRVRRREEGNKTVVEYWINDGIYGSMNCLLYDHATLSDEEDDAPLLD... | 195 |
O81415 | 3.1.1.11 | ACT_SITE 349; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 370; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MINNHPIREKPKHIIFNLLSLIFFLIFLSTVVSSQSPSYTTHKTQRLTETKTIPELIIADLNLTILKVNLASSNFSDLQTRLFPNLTHYERCAFEDCLGLLDDTISDLETAVSDLRSSSLEFNDISMLLTNVMTYQDTCLDGFSTSDNENNNDMTYELPENLKEIILDISNNLSNSLHMLQVISRKKPSPKSSEVDVEYPSWLSENDQRLLEAPVQETNYNLSVAIDGTGNFTTINDAVFAAPNMSETRFIIYIKGGEYFENVELPKKKTMIMFIGDGIGKTVIKANRSRIDGWSTFQTPTVGVKGKGYIAKDISFVNSA... | 125 |
A0JM59 | 3.4.19.12 | ACT_SITE 154; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 613; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MGDAEDFCPHLDSIGEVTKEDLILKSKGTCESCGVGGPNLWACLQDGCQSVGCGESYVDHSTLHAQAKKHNLTVNLTTFRVWCYACEKEVFLDPRGPPASQTTSPRLSHRDFPTSAHPLKSVPIAVGDDGESESDEDDIKPRGLTGMKNIGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLISELWHKKRPSYVVPSSLYHGIKLINPLFRGYSQQDTQEFLRCLMDQLHEELKEPVPLETQEREEEDRDDQREGERGGTVEEDFLSCDSGGEMGDGEGGGGVGTLSEMELLIREEVGRGLSEKEK... | 175 |
H3HC66 | 2.3.2.26 | ACT_SITE 582; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSDSSSLGGALIAAGACVLLLFCGIVLCASYCHRLDDDVAIDSVDLRSLQLREDLVDTVLDAGRSEWQCLVCAHMNHPNHELCLLCGTSAEFSTMQETVEDPLTHTRTHRNLVTSSDSAPAVMEDASKTPLHKAKTLPMLRSESSFGDSAQELEAITSMRQRALRYRRLNEMQLNPKQRGASRRRLWQRVPLPNGGFVWVRTMEPAAPGSVFARADSFVNKLRNNSFLTKNPQARDLRGDLAEQLHRKNAASMGFFSELNASGTAVKWRKTDSVALDIEPKSEDGDSAMDFEGVLAMTWREKKRWFLKQITNLAVPYTES... | 65 |
P93159 | 3.2.1.39 | ACT_SITE 418; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 494; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 498; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352" | MVNIQTNTSYIFPQTQSTVLPDPSKFFSSNLLSSPLPTNSFFQNFVLKNGDQQEYIHPYLIKSSNSSLSLSYPSRQASSAVIFQVFNPDLTISAPQGPKQGPPGKHLISSYSDLSVTLDFPSSNLSFFLVRGSPYLTVSVTQPTPLSITTIHSILSFSSNDSNTKYTFQFNNGQTWLLYATSPIKLNHTLSEITSNAFSGIIRIALLPDSDSKHEAVLDKYSSCYPVSGKAVFREPFCVEYNWEKKDSGDLLLLAHPLHVQLLRNGDNDVKILEDLKYKSIDGDLVGVVGDSWVLKTDPLFVTWHSIKGIKEESHDEIVS... | 167 |
O66953 | 5.4.99.12 | ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MPNYLLRLAFVGTNFYGWQVQPNLRTVQGEIQKALSQILCEDVKVTGCCRTDSGVHALDYIANFKTQKDFPEEKLLKALNGILPKDVGVYAVKKVSEEFNARYSVKGKVYLYKIWNSEVRNPFLYPFSWQVKREINTEVLRNILKKFEGTHDFRALTKLEEERNTVINLEEVSLNVEYPLIEIRLKASHFLRYMVRRIVGTAVKISLGLYSEEVLEELLQGKGNSPYTAPPQGLHLEKVLL | 217 |
A0A1B6Q5Z8 | 3.1.1.11 | ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGMRRARFLACIAMAAIVLLAPPSTCGVAGHSRGLRPGRSAGAGGAGDPPPLFPVNATRAEMIERQFMEWVRYMGGLRHSTFQHALARAFPSYSLVVDKNPAFGDFTTIQAAIDSLPVINLVRVVIRVNAGTYTEKVSISAMRAFITLEGAGADSTIVQWGDTADSPTGPKGRPLGTFNSATFAVNAQYFLARNITFKNTSPVPKPGATGKQAVALRVSADNAAFVGCKFLGAQDTLYDHSGRHYYKECYIEGSVDFIFGNALSLYEDCHVHAIARDYGALTAQNRQSMLEDTGFSFVNCRVTGSGALYLGRAWGTFSRV... | 125 |
D6WU58 | 2.3.1.286 | ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MSRDSSKDRAEAKPKQPPEAQSEEDNASGTSMSIDSLRKYLAEKLGISDKDDEKEKIKILDDVSVDGIAVYIKKKNCKNIITMAGAGISTSAGIPDFRSPGSGLYDNLQKYNLPHPQAIFELDFFHENPKPFFTLAKELYPGSFKPTISHYFIKLLIEKDVLLRHYTQNIDTLERIAGIPEEKIVEAHGTFYTGHCLACRKEYQLEWMKERIFKDEVPECESKDCKGVVKPDIVFFGEALPDKFYSLIENDFKKCDLLIILGSSLVVQPFASLVDRVLDTCPRLLINREKVNNGSGIMAMFGFGAGFDFDGKNNTRDVAW... | 58 |
A0A9R0JPS1 | 3.1.1.11 | ACT_SITE 310; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSHLEPSNKPEFQNMTIQIALDYALLARNHTKELEDRCQNEREKGALADCLTLLDSAIFELNKTLNPNQKGYTENDKLTWLSTSLTNLETCKPPFKIPYLSNNVVSKLISNSLAMHHSPNPNPNPNPNTQPYKQGFPTWVTRRDRKLLLQGSRLATAANLVVAQDGSENFKTIREALDDAAAKRTGNGRFVIHVRSGVYEEYLMIGTNLKNIMLIGDGMQSTIITGNRSYGGGSTTINSATVAVTGEGFIARGITFRNTAGPENLQAVALLVGSDHSVFYQCGFEGYQDTLYALSQRQFYRECDIYGTVDIIFGNAAAIF... | 125 |
Q54QZ5 | 3.2.1.28 | ACT_SITE 348; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P13482"; ACT_SITE 549; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P13482" | MDFLNKKIQKILFICILSFLIVNLTKSEISEVKDVSKFLSVGGGGTGGCQHPIYCNGTLLKTIQLTQVFNDSKTFVDMPMRTSIENVNELFNQLLLNTSKNGGPNKEELAAFLSENFYPAGYEVEPVTPVDWVPNPSFLDEITDPNLVDFARSIHGKWLELTRVFNTSGLCDGCYSSIPVNNPFVIAGSRFREFYYWDSYWIIQGLLVSDMTTTAKGMLRNFGDMITEFGFIPNGGRIYYLNRSQPPLFTQMVNKYFEATNGSDIEFLQEILPILDQEYQWWMTHRTTELTNGETGESVILNLYNVSNNSPRPESYYEDF... | 165 |
A0A0A0KUU2 | 3.1.1.11 | ACT_SITE 377; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKILHCFLLFSLLVIIHGRSFNNFMSCSQTPYPDLCFHYINPNDNIRTAHIDETYLITRFRNSAIQATLYQAMKVRDHLRSTMDLGSFDDNDRNHVALIDCLEFYEDSIAELNRSTLSSTSANSIDHSTMLSASLANHQTCLDGFRDFGFLVDDSNNFFLPIQIMSNFSKLVSNSLAITKAIAAAPSTSSSTSCGQPLLDGLCPEWVYDDDKTLLQDMVGKGADMVVAQDGSGDFRTISEAVAAAEEARKGSGSGRFVIYVKGGIYKENVVIEKRMKNIMMVGDGMDRTIVTAMKNVQDGSTTFQSATFAVAGEGFIAKD... | 125 |
O33926 | 5.6.2.2 | ACT_SITE 119; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MPEILINKPVEDELVESYLLYSMSVIVGRAIPDVRDGLKPVQRRILYGMYELGLKHNSPTKKSARIVGEVMGKYHPHGDAPVYDALVRMAQPFTMRYPLIEGQGNFGSIDRDPPAAMRYTEARLTRLAEEMLEDIEKNTVNMIDNFDGTLKEPEVLPSKVPNLIINGASGIAVGMATNIPPHNLSETVDALIYLIDHPEATVEELMQFIKGPDFPTGAVVVNASELKKVYEEGRGRIIVRGKVHVEDGKRVKRIVITEIPYGVSKAGLIEQIAKIAKDDESLPIRNIRDESDKRGMRIVIEIPKDANEEVIINNLYKRTA... | 222 |
M3W328 | 3.1.1.4 | ACT_SITE 87; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 131; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MRAGPAAGAGAEAGPGRTPEMKGLLTLAWFLACSVPAVPGGLLDLKSMIEKVTGKTALTNYGFYGCYCGWGGRGTPKDGTDWCCWVHDHCYGRLEEKGCHIRTQSYKYRFARGLVTCELGPLCQVQLCACDRKLVYCLKRNLRSYNPRYRYFPNILCF | 130 |
Q42534 | 3.1.1.11 | ACT_SITE 404; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 425; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MAPIKEFISKFSDFKNNKKLILSSAAIALLLLASIVGIAATTTNQNKNQKITTLSSTSHAILKSVCSSTLYPELCFSAVAATGGKELTSQKEVIEASLNLTTKAVKHNYFAVKKLIAKRKGLTPREVTALHDCLETIDETLDELHVAVEDLHQYPKQKSLRKHADDLKTLISSAITNQGTCLDGFSYDDADRKVRKALLKGQVHVEHMCSNALAMIKNMTETDIANFELRDKSSTFTNNNNRKLKEVTGDLDSDGWPKWLSVGDRRLLQGSTIKADATVADDGSGDFTTVAAAVAAAPEKSNKRFVIHIKAGVYRENVEV... | 125 |
P47058 | 3.5.4.33 | ACT_SITE 56; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01083" | MQHIKHMRTAVRLARYALDHDETPVACIFVHTPTGQVMAYGMNDTNKSLTGVAHAEFMGIDQIKAMLGSRGVVDVFKDITLYVTVEPCIMCASALKQLDIGKVVFGCGNERFGGNGTVLSVNHDTCTLVPKNNSAAGYESIPGILRKEAIMLLRYFYVRQNERAPKPRSKSDRVLDKNTFPPMEWSKYLNEEAFIETFGDDYRTCFANKVDLSSNSVDWDLIDSHQDNIIQELEEQCKMFKFNVHKKSKV | 186 |
Q8RE86 | 1.1.1.205 | ACT_SITE 305; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 401; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1" | MNGKIVKEGITFDDVLLIPAKSDVLPNEVSLKTRLTKKITLNLPILSAAMDTVTESDLAIALARQGGMGFIHKNMSIEEQAAEVDRVKRSESGMITNPITLNKDSRVYQAEELMSRYKISGLPVIEDDGKLIGIITNRDIKYRKDLDQPVGDIMTSKGLITAPVGTTLEQAKEILLANRIEKLPITDQNGYLKGLITIKDIDNIIQYPNACKDELGKLRCGAAVGVAPDTIERVSALVKAGVDIITVDSAHGHSQGVINMIKEIKKNFPDLDIVGGNIVTAEAAKELIEAGVAAVKVGIGPGSICTTRVVAGVGVPQLTA... | 3 |
Q9UTJ7 | 1.3.5.1 | ACT_SITE 333; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9YHT1" | MLRFRKVAPSLKNGGNLKLFSTSSTLKKIASSQPLRAKQVSTSESVKYPVIDHTYDAIVVGAGGAGLRATFGLAEAGFNTACITKLFPTRSHTVAAQGGINAALGNMTKDDWRWHFYDTVKGSDWLGDQDAIHYMTKEAPKAVLELEHFGVPFSRTKEGKIYQRAFGGQSLEYGKGGQAYRCAAVADRTGHSILHTLYGQSLKHNTNFFIEYFAMDLIMEGGECRGVIAMNLEDGSIHRFRAHKTILATGGYGRAYFSCTSAHTCTGDGNAMVSRAGLPLQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLLNSKGERFM... | 28 |
A0A3B3HDF3 | 2.3.1.48 | ACT_SITE 452; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MPRRRQRAMAGSVSDGTEDSDSSAEREQTHSSESDGNMPKRQRLTRASTRLSQSSQDTPDLKRAADHDESPPLTPTGNAPSSESELDISSPNASHDESHTKDQASRDSDKDLSHRPKRRRCHETYNFNMKCPTPGCNSLGHLTGKHERHFAVSGCPLYHNLSADECKVKAISREKQEEEAKTQEENSSRHATRHQTPTPKQSKYKEQVAEMRKGRNAGQQKEQKEKHTEHRQTHGNTREPLLENITSEYDLELFRKAQARASEDLEKLRIQGQITEGNNMIKTIVFGRFELDTWYHSPYPEEYARLGRLYVCEFCLKYMK... | 61 |
B3RW46 | 2.3.1.48 | ACT_SITE 343; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MVKTTLTSSTNENDGGNSVDGSTSRGENKENNDNLSNDIGSRRFEKPIQVADKCMARRIDDTWQLAEIIHIRPSLTDDTGSRYYVHYVGYDRRLDEWLGIDRLKPASVKETNEASIRPDIWSLAENQERKVTRNQKRKHDEINHIQKTYAEMDPTTAALEKEHEAITKVKYIDKVQIGKYEIDAWYYSPFPDEYGKQSKIWICEYCLKYMKYESTFKHHLTICNHKQPPGGEIYRKCSLSVFEVDGKNHKLYCQNMCLLAKLFLDHKTLYFDVEPFLFYQLTEVDEDGCHLVGYFSKEKESADGNNLACLLILPPHQRKG... | 61 |
Q54VC0 | 2.7.11.1 | ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKIKDFNIECDNLKIEENEFSKGSFAKVYKGSYYGNPVCVKVIKKDTLIDKESWVFLKREIGILKNLLNQGHKNIIRFIGIGEKDSLLFLVTELINGGDLGNILLDHKFHIPWSLRVKIAKDIAEGMEYLHSKQIMHRDLKSNNLLLGRNWTIKICDFGFAKEITIQNPLSMTICGTDEFMSPEVILGIQYSYSADIYSFGMVLLELITRSKLDERLPQNNFDIDYEELQNKIPSECPREFLELSMKCCNYDPNDRPSFTDIVQTLDQLAIKLVKETPDGPYPSTPIVVSNPHFDDQSINDWCMLSLIPDDCLENLNEFA... | 99 |
Q63739 | 3.1.3.48 | ACT_SITE 72; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 104; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ | 149 |
F6U3B1 | 2.7.10.1 | ACT_SITE 1045; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MEGQQAVTMLFLGLGLGLGSGLGSGPGSGLGPGVQTAAGELGVAPDRPSLSIQKDMLTVMVNATLQITCRGQRDLDWLWPNNHSSPENRVEVTDCSDSPFCKMLTIAKVAGNDTGAYKCVYRDDRMESSIYVYVQDYRSPFTTSVSDQHGVIYITENKNKTVVVPCLGSTANLNVSLYARYPEKRFIPDGDKVSWDRRTGFTIPSYMISYAGMVFCEARINEESYQSPMFIVVVVGYKIYELALTPSHRVELAVGEKLVLNCAAKTEPNVGIDFRWDYPSAKLQARKPVTRDLKTQTGSELKKFLSTLTIDRVARADQGY... | 97 |
A0A2R6W107 | 1.11.1.7 | ACT_SITE 145; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEIMTWTHVDRSSVMFIFIGAMLFIAPPSCTADLVSTVVATVLPSPPPPPTILQSPPPPPNPVSPPPPKFASPPPPTAVSPPPPKAASPPPPTAISPPPPAPPGLDPAYYSVSCPSATAWVQNMTASIVASDRTMAAALLRLHFHDCFVRGCDASVLLDSTPGNTAEKDSLANANSLRGFTQVDQVKAKLEEVCPGVVSCADILALTARDAIVKIGGQSWVVYLGRKDGVVSVASESMSSLPSPFATYTQLVQGFAAVGLSEKDMVVLSGGHTIGTTKCGAFSQRLYGFSGPGAINGTDPTLDPEYAKVLKQQCPQNAPL... | 14 |
A9UY15 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 483; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MTESNDHVDQGNFDLLKVLGQGSFGRVFLVRKRDGHDAGTMYAMKVLKKASLKVRDRFRTKAERDLLAAIHHPFIVHLHYAFQTEGKVYLILDFLRGGDLFNRLSNEVMFTEKDVQFYLAELALALEHLHNLGIIYRDLKPENILLDAGGHIALTDFGLCKEYTEEGGKTYSFCGTQQYMAPEVINRKGHDTSADWWSFGVLMYEMLTGDLPFDSDNRKTLMQMILKARLSMPQHLSPEAQSLLRKLFKRVPSARLGYNGADEIKQHPFFATIDFDKLFRKELEPPFKPNLTGQEDLHYFDRDFLKMAAVDSPVPPPSAN... | 99 |
G3SHL1 | 2.7.11.25 | ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MVQLVGKGGANLGRRAHRAGADWAPGAEGGAAGGGAGRSWGLARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPPPPRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAGAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRTPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSY... | 105 |
Q8Y3U2 | 2.3.1.286 | ACT_SITE 114; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01968" | MNKLNEALKKAERIVFLTGAGVSVPSGIPDYRSKNGLYAGMSSPEYMLSHTCLVREPEKFYQFVTENMYYPNAVPNVIHKKMAEIETEKDVTIITQNIDGLHEKAGSKKVVNFHGSLYHCYCQNCGMTVTAKDYLKSDIHTDCGGVIRPDVVLYEEAISESAIDQSLTAIRKADLIVIVGTSFRVSPFCNLTDYRNKKARIFAVNKERISLPYPFEMMESDAVKVFEEI | 58 |
B6K2R2 | 3.2.2.27 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MKRKNPGAPVLGEMKNLKQRCVNQFFKRQTVNNSASTMDVNTRTQKKEDWIKNLNAEQKKLLQLEITTMDDSWFMALKDEFLKPYFLQLKKFLMTEWQSQRVFPPKEDIYSWSRLTPLNKVRVIILGQDPYHNVGQAHGLSFSVRAGIPCPPSLKNIYRTIKNDYPDFEIPNTGYLVPWAEQGVLMLNVNLTVRAHQANSHAGKGWESFTHAVLQTILKRHPKGLVFLAWGTPAANRLKNLSLATHCVLRSVHPSPLSAHRGFFECQHFKKTNQWLKEKFGEEYCIDWGAVSGKKKQVAPKDATLPTEVKKVVTATTSSE... | 173 |
I1J3Q0 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAWSNANKAVLAMGLVAALLFPAATASSALSYDFHDNSCPNLLNMVYNAVDAARQEDPGVVPGLLRITYHDCFPQGCDGSILLTGPNSEQKMPQNAGLRQSALDLIESIRDKVHLACGPTVSCADITNLATRVAVVQSGMPGYNVTLGRLDSLEPASAAQVAALPGPDLVVSELVDSFASRGLDTTDLVALSGAHTIGKTSCRSLKKRWGENADFVDLLHSFCARYPEHKVDLDVISPNDFDNQYYINLQRGVGVLNSDMALVRDDPYIRNLVNGFARDQGWFFSQFSNSMSKLANLPPKLQGNDGEIRFSCSKRNNGPM... | 14 |
Q4X180 | 3.1.1.3 | ACT_SITE 320; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037" | MKSSRKRTKRRVLQDMSISGLLLSVALLPSVVSAQDHVYLDPSSSGSPYLGPQIPLTGLPALTGTHEFTLRHIYQRGTHDQPDLHRRLDIKPHTRLWAVSDDGLEKELVTFDTPLVASSSPLTIQRLADRRLSVIEGYLAAARSRGEAVALSPSEWVMDTLAGPNVTDKESVLTFAKMTANDYIEEPGSGDWHYIHGRFNYSSSFGWQSDGLRGHIYADKTNSTIVISLKGTSPALFDGAGTTTNDKINDNLFFSCCCGQGGSYLWRQVCDCQQSAFTANLTCIVEAMNDENRYYRAAIDLYSNVTDMYPDANVWLTGHS... | 128 |
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