Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
P06700 | 2.3.1.286 | ACT_SITE 364; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEK... | 58 |
A0A9J7LS26 | 3.2.1.23 | ACT_SITE 185; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 265; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MAATVKMFVALSLFVLVLQGQRAAGRSFSIDYDNNTFLKDGEPFRYISGSIHYSRVPRSYWQDRLTKMYAAGLNAIQTYVPWNLHEPKPGKYDFTGNNDIEAFLKMANDTGLLVILRPGPYICAEWDMGGLPSWLMKDNSSIVLRSSDPAYLGPVDTYMAQLLPKIKPYLYNNGGPIITVQVENEYGSFYTCDYDYLRHLRELFIQYLGPDVVLFTTDGWWDGVLKCGTIDGLYTTVDFGPGTDPAGAFKGQRKHQPKGPLVNSEFYTGWLDHWGQPHAHTDKDKVATYLEKILELNASVNMYMFEGGTNFGYMNGANGP... | 163 |
Q9VEJ0 | 1.11.1.24 | ACT_SITE 85; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P35705" | MSFVARSLIRNVPLMGKAILSQQKQIAARLLHQTAPLAAVRVQQPAPDFKGLAVVDNSFQEVKLEDYRGKYLVLFFYPLDFTFVCPTEIVAFSERIKEFHDINTEVLGVSVDSHFSHLTWCNVDRKNGGVGQLKYPLLSDLTKKISADYDVLLDKEGISLRGTFIIDPNGILRQYSINDLPVGRSVDEVLRLIKAFQFVEQHGEVCPANWNPNSNPATIKPDVEESKKYFSKHG | 12 |
Q4WBK0 | 1.2.1.12 | ACT_SITE 174; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MAPSINDFPHSTSSPQSPVCKIGINGFGRIGRNVLRAALNRPDLQIVAINHTCTTIDDLIHLIRYDSSMGNLPPSIPIHALSDTLLSINGHQIALTSERTLQNLDWAALGAEYVIECTGKFTKHAQALEHVTHGRAKRVIISAPSADAPTFVFGVNSDEYTADEARRVISCASCTTNCVTPVLKVLQGQFGIAQGFLTTVHAATRSQSVLDGYSRKNRRLGRSVFDNIIPTTTGAAKAIATVLPALSGKVTGVSIRVPTPNVSMIDLTVSTEKPTSLAEVLAVFRRAAKGELAGVLAVSEEELVSSDYLGNPHSAIIDAP... | 22 |
A0A1U8FQB5 | 5.1.3.3 | ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 320; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MSSKINLLICLFFILHLWAAANVTAQEIGIYEIKRGDFFVKVTNYGARVISVLLPDKHGNIGDIVLGYDTIQEYMNDTNAFGAIVGRVANRISGARFTLYGTHYKLIANDGNNTLHGGPKGFDHIVWKVSKYTKGGANPRITLTYHSPDGEQGFPGDLLVSVTYALKDRYKLIVTMKAKALNKATPVNLAQHTYWNLGGHNSGHVLSNEIQIFASHITPLDEHFIPTGQIVPVKNTPYDFLKPREVGSQFNKLQNGYNINYRLESTKKMKPVAIVHDKKSGRAMNLQATAPGVQFYTSNSLVKKGKGGYVYQPYSALCLE... | 211 |
W5NJN7 | 2.7.11.13 | ACT_SITE 708; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000552-1" | MSACSSSSPPSLPKSYPHSQHPSAPPTPSPSPSPPAGLYSRLSNGSLSAPSPTNSRGSFHGVSFLLQIGLTRETVTLEAHDLSISAVKDLVCSIVDQKFPECGFFGMYDKILLFRHDLNSENILQRLTSADDIHEGDLIEVVLSALATVEDFQIRPHALFVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPIPIEHATVPIEEVRSSERSHQEAGKRIPSWSGRPIWMEKMVLGRVKVPHTFVIHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCS... | 100 |
A0A8J1KM14 | 3.1.4.11 | ACT_SITE 377; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 424; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAKYADCASLLNTPKCRRMESVVLSHSFGVKPAGSSQAVQVLVGFPKGNMAKVYEFNWQKAVPSFMQDGAVFDRYEEESFVFEPSCLFKVDEFGFFLTWKSEGKEGQLLECSLINSIRYGAVPKDPKIVSALEAAGKCEQELEGKIVCVCCGTDLVNISFTYMIAESSDLAKQWVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPRLNEILFPFFDGKRAMQI... | 153 |
B9RZV6 | 3.2.1.23 | ACT_SITE 385; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055" | MFCRHSKMAFFAIFVSAAKLAGVLATVTVAANVFSFERYRRKNLRRFNSPIDESSEILASFNVNAEEENEFFFGLATAPAHVEDRLNDAWLQFAAENPCEKSQSHQGLEPADALMGSATGDGGSQQASLSGKVNKKKKQLKFAMEAMIRGFYKYTEDEAPHEECHHNVAAWHNVPHPEERLKFWSDPDTELKLAKDTGISVFRMGIDWTRIMPEEPVNGLKETVNFAAVERYKWIISRVRSYGMKVMLTLFHHSLPPWAGEYGGWKLEKTVDYFIEFTRTSSKSIVGVAHHVSFMRPYGIFDVAAVSLANSLTLFPYVDS... | 163 |
Q9LSF1 | 2.7.11.1 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLEGDEKQSRALDFNRLEVLSLLGRGAKGVVFLVRDDDAKLLALKVILKEAIEKKKKGRESEDDEYKRVSFEQGVLSRFDHPLFPSLHGVLATDKVIGYAIDYCPGQNLNSLRKMQSESMFSDEIIRFYAAELVLALDYLHNQGIVYRDLKPDNVMIQENGHLMLIDFDLSTNLAPRTPQPSPSLSKPSPTMKRKKRLFRFTSFCNSGISPQESISVHSSSTLAVSDSSGEKSNSFVGTEEYVAPEVISGDGHDFAVDWWSLGVVLYEMLYGATPFRGSNRKETFYRILSKPPNLTGETTSLRDLIRRLLEKDPSRRINV... | 99 |
P53686 | 2.3.1.286 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:20726530" | MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQS... | 58 |
A0A1U8MLP2 | 3.2.1.143 | ACT_SITE 264; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 282; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 283; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MEDSAELESILPYLPLVIGSSRRLLWPSKVVEALEAMSRGPDHSLVNCGEVLSIAISDMSACLSLADPLALSAPLGYALFFDELMSGADSRKWFAEDIPKLANLLLRLPSLLEVHYQNSRAYGYGLRILGPQQPGMVLLSQELIGALLACSLFCLFPISNRGLKHLPTINFDQLFASLYDSYSESQENKVRCIICYFQRICLQMPTGSVSFERKLLSLEHHPWQSFLSYPYADFWTKSTIPLCPFQVHSSGLIEDHAIEALEVDFANKYLGGGALHRGCVQEEIRFMINPELIAGMLFLPSMADNEAIEIVGAERFSDYT... | 159 |
Q4PE27 | 2.3.1.225 | ACT_SITE 211; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03199" | MTNQDPDDGAYPSSQSDDDGIEALAINRQSRPLLAYEDQAAGQSDAFTDRDIPASTAPLTGRRRTPLSWTEVIWVSLTLLLIAVLGYSSQLYVMLPYYEKTPSFSPQALAAVLVPFNLGLLAIYYNYWLCVTTDAGSVPAGWQPEWSALEPVASLAELEHLHLVAEEEPSLELKQAIYRPRYCKTCSAFKPPRSHHCKTCQRCVLRMDHHCPWLANCVGHFNHAHFIRFLFYVDVTCLYHLIMISCRVLDSFNSYTYWREPCARELVWLVVNYALCIPVILLVGIFSLYHFYCLAVNQTTIESWEKDRTATMIRRGRVRK... | 57 |
Q9SJM3 | 2.7.11.1 | ACT_SITE 684; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MESFAGSCEIVEEKDAVRLAKHSSRYCMSPLGSSKDMEQRPALKSGYQGSMEYDIDQLFQSITIKPSPRRVMGSSFHHLETSASAGTSRSTSPSNKGAMKKPFPMGTPRSPRVGPSDSISLKQALRDLCISKASEMASQKRLSKSAAASPRVSEADRIKTLYRQVLNESAGKPGLPVDKGKSLVEISLTPVVDIPSSSQSVPQRYDVLETEPSNFISEPSQAEILLHVLGNGSGIKTVGYGMLETVSLCKSNKSGSCLSSGSGDYEIEIDENHTSPPHMVIEDQLVEIDKHVTSLPSCSGSKVDTEELDKSIVSSARVKS... | 99 |
A0A0K3AV08 | 2.7.11.25 | ACT_SITE 297; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MEQASVPSYVNIPPIAKTRSTSHLAPTPEHHRSVSYEDTTTASTSTDSVPEVRIRSESSQVSRESPPIRASKAFVASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRGELNGKVGLFPSNYAREVTYKDNLVEFKQDEIMLPVAVRTLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEEVCLCMDEEMFQY... | 105 |
A0A2C9UYZ5 | 3.2.1.23 | ACT_SITE 226; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MIRPNSASNLSSKFTITMARKGGPKITLFLLFISIIAFGVFVPVFAPLPSLSSSSHSHRHRKVFTANARSFEIADDVFWKDGKPFRIIGGDLHYFRILPEYWEDRLLRAKALGLNTIQTYVPWNLHEPQPGNLVFEGIADLVSFLKICQKLDFLVMLRAGPYICAEWDLGGFPAWLLAIEPALKLRSSDPAYLKLVDKWWGILLPKVAHLLYNNGGPIIMVQIENEFGSYGDDQSYLHHLVKLAREHLGENIVLYTTDGGTRETLEKGTIRGDAVFSAVDFSTGEDPSPIFKLQKEFNAPGKSPPLSAEFYTGWLTHWGE... | 163 |
Q9XIW0 | 2.7.11.1 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MESLPQPQNQSSPATTPAKILLGKYELGRRLGSGSFAKVHLARSIESDELVAVKIIEKKKTIESGMEPRIIREIDAMRRLRHHPNILKIHEVMATKSKIYLVMELASGGELFSKVLRRGRLPESTARRYFQQLASALRFSHQDGVAHRDVKPQNLLLDEQGNLKVSDFGLSALPEHLQNGLLHTACGTPAYTAPEVISRRGYDGAKADAWSCGVILFVLLVGDVPFDDSNIAAMYRKIHRRDYRFPSWISKQAKSIIYQMLDPNPVTRMSIETVMKTNWFKKSLETSEFHRNVFDSEVEMKSSVNSITAFDLISLSSGLD... | 99 |
Q9YGA9 | 4.2.1.20 | ACT_SITE 36; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 47; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MFEKGSLIPYLTAGDPSVEKTLEFLLAVEEFAGLIELGIPFSDPMADGKTIQESHYRALRNGFKLDDTFRILREFRRHSSTPVILMTYYNPVFRTGVKKFLGEAKASGADGILVVDLPVSHAGEFLDAAKEEGLKTVFLAAPNTPDERLREIDKASTGFVYLISLYGTTGARDRLPETAFEFVRRARKICNNKLAVGFGVSRREQVEELLKAGADGVVVGSALIELISRSENPVEELRRKVAELSGYSRAL | 202 |
Q0JBL5 | 3.4.21.92 | ACT_SITE 181; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 206; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MLPVAPTRQPLTASSWPRLAAAGPTPPRPNLPLNPAPPPPPPPPNPSPAAMLRRLAAAAPRAFFSSSTPHAPPPPAGYTQRREYGLVPMVIEHTSRGERAYDIFSRLLKERIVCIHGPITDDTASLVVAQLLFLESENPAKPVHLYINSPGGVVTAGLAIYDTMQYIRSPVTTLCIGQAASMASLLLAAGARGERRALPNARVMIHQPSGGASGQASDIAIHAKEILKVRDRLNKIYAKHTSQAIDRIEQCMERDMFMDPEEAHDWGLIDEVIEHRPVSLVSDAVGSDLPNLGGGGDGANKATDEPSPA | 179 |
Q8RZV7 | 2.7.11.1 | ACT_SITE 1129; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MVSNSFWLFILLVSFIPISAWAESRDISTLFTLRDSITEGKGFLRNWFDSETPPCSWSGITCIGHNVVAIDLSSVPLYAPFPLCIGAFQSLVRLNFSGCGFSGELPEALGNLQNLQYLDLSNNELTGPIPISLYNLKMLKEMVLDYNSLSGQLSPAIAQLQHLTKLSISMNSISGSLPPDLGSLKNLELLDIKMNTFNGSIPATFGNLSCLLHFDASQNNLTGSIFPGITSLTNLLTLDLSSNSFEGTIPREIGQLENLELLILGKNDLTGRIPQEIGSLKQLKLLHLEECQFTGKIPWSISGLSSLTELDISDNNFDAE... | 99 |
A0A8I3P4H0 | 1.3.5.1 | ACT_SITE 398; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611281-1" | MPSAARSADPVRRRDAPTAGSRRGAQARCPRVLGWARLDAQAQCGAGVGGTARWRTDMSGVRAVSRLLGARRLALTRAQWPAAWQTGTRSFHFTIDGNKRSSAKVSDSISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGRIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRT... | 28 |
Q22431 | 2.3.2.31 | ACT_SITE 300; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MDDEDMSCTSGDDYAGYGDEDYYNEADVDAADDVAVTPTHSEEADYECLSVNQVERVFIDGVNSLVSRISINEKFARILLQANHWDVDKIARLVRNDRNDFLRKCHIDAKPEPKRKLSSTQSVLAKGYCSVCAMDGYTELPHLTCGHCFCEHCWKSHVESRLSEGVASRIECMESECEVYAPSEFVLSIIKNSPVIKLKYERFLLRDMVNSHPHLKFCVGNECPVIIRSTEVKPKRVTCMQCHTSFCVKCGADYHAPTSCETIKQWMTKCADDSETANYISAHTKDCPQCHSCIEKAGGCNHIQCTRCRHHFCWMCFGDW... | 67 |
P21179 | 1.11.1.6 | ACT_SITE 128; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 201; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MSQHNEKNPHQHQSPLHDSSEAKPGMDSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSENYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERIVHARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSADTVRDIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPHWAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHTFRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRR... | 13 |
A0A2R9YJL5 | 2.1.1.37 | ACT_SITE 1254; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLA... | 47 |
A0A072UU49 | 3.1.1.11 | ACT_SITE 376; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTIIMGKILLTLLLLSSIFSIATSSKRRSRSSNNNIDWWCNQTPHPETCKYYTKQTHYYHNKSIKHKTKFREILIHLALERAVVMRNMAHNFGQNSWITQKKKSVSRDCLKLFDNTVFHLNRTFLDLHKKKSCSSFDAQTWLSTAYTNIETCRNGALELNIPKFIVPIMKVNMTQIISNGLFVNWEFVKRDGRVRYTNDVTEEGFPRWFSVRERKLLESSRAIKAHIIVAKDGSGHFKRVQDAINAAGRRRFKTRFVIRVKKGVYRENIVVGKMNDNIMLVGDGSRNTVITSNRNVQAGFTTYSSATAGIDGLHFIARDI... | 125 |
O64768 | 2.7.11.1 | ACT_SITE 1102; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDQAKGYEHVRYTAPDPRDEGLGSINQRFSHDSSTNVNTYVRPPDYGVSTPARPVLNYSIQTGEEFAFEFMRDRVIMKPQFIPNVYGEHSGMPVSVNLSALGMVHPMSESGPNATVLNIEEKRQSFEHERKPPSRIEDKTYHELVQSAPVISSKNDTGQRRHSLVSSRASDSSLNRAKFLCSFGGKVIPRPRDQKLRYVGGETRIIRISKTISFQELMHKMKEIFPEARTIKYQLPGEDLDALVSVSSDEDLQNMMEECIVFGNGGSEKPRMFLFSSSDIEEAQFVMEHAEGDSEVQYVVAVNGMDLSSRRSSLGLSPPG... | 99 |
P35039 | 3.4.21.4 | ACT_SITE 88; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 132; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 229; /note="Charge relay system"; /evidence="ECO:0000250" | MSIKFTTLLAVLFALLAYARAQAERRHKLTRPVHRFAPNRPYLAGKRIVGGFVINISDAPYQISLQYDDDHNCGGSILSSKWILTAAHCINDNAPSKPTVRVGSSKHASGGTVIRVARIVPHPMHGSKNNYDIALLELKNELTFSEKVQPIALPEQDEPIEEGTMGIVSGWGLTLSEADSNDVLRATNVPTVNQQECNKAYQSRYGGITDQMFCAGYKQGGQDTCRQDSGGPFVAKGKLIGVISWGHECALAGYPGVYARVASVRDWIRTTSGV | 177 |
A4SK74 | 2.2.1.2 | ACT_SITE 132; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MADKLTQLKALTTVVADTGDIEAIKRYQPIDATTNPSLVLKASEIPEYAALIEDAISWAKSQSQDKAQQIIDAGDKLAVNIGLEVLKIVPGRISTEVDARLSFDTEASIAKARKLIRLYNEAGIANDRILIKLASTWEGIRAAEVLEKEGIQCNLTLLFSFAQARACAEAGAFLISPFVGRILDWYKAKHNRDYTPSEDPGVVSVTAIYDYYKQHDYPTVVMGASFRNTGEILELAGCDRLTIGLPLLEELSKTEGAVVRKLNYTGERKAKPTPMSEAEFRWELNQDAMAHEKLGEGIRMFAVDQGKLETMLASRL | 52 |
Q7NKF4 | 6.3.4.2 | ACT_SITE 381; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 506; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 508; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MTKYVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVTILKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFTDTDVSKLNNVTTGSIYQSVINKERRGDYMGGTVQVIPHITNEIKERIRRVAHDTNPDVVIVEVGGTVGDIESLPFLEAIRQFRKDVGRENVLYIHVTYILHIPTAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLSVGIKDKISEFCDVPVRAVITCQDAQTIYAVPLNLEREGLAHQAITLLGLEQRQPDLRDWEILVDRICNPSRAVTIAIVGKYVRLSDAYISVVEALRHAAVAL... | 252 |
Q92249 | 5.3.4.1 | ACT_SITE 50; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 170; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 173; /note="Nucleophile"; /evidence="ECO:0000250" | MVLLKSLVVASLAAAVAAKSAVLDLIPSNFDDVVLKSGKPTLVEFFAPWCGHCKNLAPVYEELATALEYAKDKVQIAKVDADAERALGKRFGVQGFPTLKFFDGKSEQPVDYKGGRDLDSLSNFIAEKTGVKARKKGSAPSLVNILNDATIKGAIGGDKNVLVAFTAPWCGHCKNLAPTWEKLAATFASDPEITIAKVDADAPTGKKSAAEYGVSGFPTIKFFPKGSTTPEDYNGGRSEADLVKFLNEKAGTHRTPGGGLDTVAGTIAALDEIVAKYTGGASLAEVAEEAKEAVKSLKNSAELKYADYYLRVLDKLSKSE... | 215 |
A0A1S4H881 | 1.8.1.4 | ACT_SITE 484; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MQCNIRYLVNVAVKGNASLRNHGAVLGALYGRYYSTTHDADLVVIGSGPGGYVASIKAAQLGMKTVCIEKNDTLGGTCLNVGCIPSKALLNNSHYYHMAHSGDLAARGIHVENVRLDLDVLMGQKTKAVKSLTGGIAQLFKKNKITHINGFGTITGPNTVVAKKADGSEETVNTKNILIATGSEVTPFPGIEVDEETIVSSTGALKLKAVPRRLGLIGAGVIGLELGSVWGRLGADVTAIEFLSTIGGVGIDQEVSKNFQKILTKQGMKFMLGTKVMSAAKTGSGVSVTVESVKDGSQQNLEFDVLLVCVGRRPYTEGLG... | 36 |
Q75JK0 | 2.7.12.1 | ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 507; /note="Proton acceptor"; /evidence="ECO:0000250" | MHYHNKDDWEEISFIGEGQYGRVIKCRKKNGFILNEQVDYVAIKIISKDKFKRNETDILEKIRLFNIPRYYSHAEDDNFIYIYMEYIEGENLANILKTKKQGRFKESRIISMIADLVETLSFLHKHHVIHRDIKTANLVLDKNKNLKLIDFGASTIQNKKQFEQYLNETTNNNNNPNNNNNNNNNNNNNNNNNNNNNNNNNNINNINNNNDLNGSGSGISTYLNEQYKQSSFAIIGTFNYMAPEVKRNYRATRKSDVWSLGCTIIEMAGGDLSQKLNGIPIIPDHLSDTLKDFLNHCLVIDPKKRSYMEELLSHKLIVHI... | 107 |
A0A0R4IAH0 | 3.5.1.98 | ACT_SITE 771; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MTSHSRPDGLPSKEQPLELLKPSGVNHIPPVDVSVALPLQVPPSAIPMDLRVDHQFALAPTDPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKHQQDLLALKHQQELLEHQRKLERHRQEQEMEKQQREQKLQLLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRSLNHCLPSDPRYWYGKTQHSSLDQSSPPQTGISTYNHPVLGMYDPKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTAKKRSLDMAESACSSAPGSGPSSPNNSSNNITNENGIAGSISNS... | 184 |
Q0JJD4 | 3.2.1.78 | ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 349; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036" | MAVGNGLILYHILGLASCIALVYFSLGEVDLRDALPSLPFSGGASRAAAASLPFVERRGKRLFLDGRPFYINGWNSYWLMDLAVEPNTRPRVSSMFRTAVSMGLTVCRTWAFNDGSYNALQLSPGHFDERVFKALDRVVAEASEHGVRLILSLANNLDAYGGKRQYVRWAWEEGVGLTASNDSFFFDPAIRDYFKVYLKTLLMRKNHLTGLEYRDDPTILAWELMNEPRCTSDPSGDTLQRWMEEMSAYVKSIDKKHLLTVGTEGFYGPTSSQEKLNINPGEWFPNNYGADFIRNSKIQDIDFASVHVYPDNWLQHASLD... | 172 |
A0A139WMZ3 | 2.7.11.1 | ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 530; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MANSTRRYRAFGVSRSLRIVSSQSGDADEAVGVEEAGPTEGEHEIELGELVRNGHDKADPSQFELLKVLGEGSFGKVFLVRKVVGADNGRLYAMKVLRKATLKVRDRHRTKMERNILVDVEHPFIVKLHYAFQTAGKLYLILDFLRGGDLFSRLSKEVMFTEEDVKFYLAELALALNHLHTIGIIYRDLKPENVLLDADGHIALTDFGLSKLPLEEGKAYSFCGTVEYMAPEVVNRKGHSFAADWWSFGVLMFEMLTGSLPFQGANRRDTMTQILKAKLGMPANLSSEAQSLLRALFKRNPANRLGAGPGGVEDLKKHEF... | 99 |
O65238 | 2.7.11.1 | ACT_SITE 639; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKSTFLLLLLLLSLNLLFVFVSCASSIEFVYPNFTASNLRFVDSSKGAFLLSRNSIFKAGLFSPGGDDSSTGFYFSVVHVDSGSTIWSSNRDSPVSSSGTMNLTPQGISVIEDGKSQIPVWSTPVLASPVKSLRLTDAGNLLLLDHLNVSLWESFDFPTDSIVLGQRLKLGMFLSGSVSRSDFSTGDYKFLVGESDGLMQWRGQNYWKLRMHIRANVDSNFPVEYLTVTTSGLALMARNGTVVVVRVALPPSSDFRVAKMDSSGKFIVSRFSGKNLVTEFSGPMDSCQIPFVCGKLGLCNLDNASENQSCSCPDEMRMDA... | 99 |
A0A251TAU0 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTQDAKILHLLLLIGYSLLISFISPSDSSLEYDYYRESCPQAQQVIRSTLRRIYDRNSTVAPAILRLVFHDCFVQGCDASVLLDRTVFMGSEKDTLPNQSLRGFDHIDIIKSELENVCPGVVSCADLLVVAARESVVLAGGPFYPVHTGRKDSDHSFPEISYELPSPLDDLPTTIARFASRGFTVKETVTLLGAHSTGMIHCKFFERRLYKFGGTDQPDPSLDPEFAELLRSVCNSTQTQSQSESSSASPSASPSPSTTSTKSDEERSMKMDYEGRGSGFGILYYRGLLQGRGILFVDQQLTAGEETASWVRQYASDVSM... | 14 |
B7PNI3 | 5.4.99.12 | ACT_SITE 130; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR641708-1" | MSSTVRRFLYSVFFGQRSPQLPFWSSIMSEGGTISGAKHALDGSEDKGAKRLKSETETSNSESQLGKAKAKKMALCMSYNGKDYLGMQRNPGTKTIEDDLLQAMYKGDLILKEHVDVPQAMKFQRAARTDKGVSAVRQIVSLKLPTNLTVEEMVDKINSHLVDQIRVIDIKRTTRGFNCKNSCDSRTYTYVLPTFAFAPPESPAEESYRITEERIGEVNNVLALYKGCHNYHNFTSGKKSEDPSAMRYIISAECAQPFVQGDQEFVQVQIKGQSFMLHQIRKMVGLVIAIMRGCTKETTIRRAWGPEKLDLPIAPALGLM... | 217 |
Q9HUK1 | 5.6.2.2 | ACT_SITE 127; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00936" | MSESLDLSLEGVERRSLAEFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADSKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTVDWVPNFDGTLDEPAVLPARLPNLLLNGTTGIAVGMATDVPPHNLREVASACVRLLDQPGATVAELCEHVPGPDFPTEAEIITPRADLQKVYETGRGSVRMRAVYRVEDGDIVIHALPHQVSGSKVLEQIAGQMQAKKLPMVADLRDESDHENPTRIVIIPRSNRVDVEELMT... | 222 |
Q70EL1 | 3.4.19.12 | ACT_SITE 42; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035"; ACT_SITE 302; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035" | MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQMVHYISTTSLCNQAICMLERREKPSPSMFGELLQNASTMGDLRNCPSNCGERIRIRRVLMNAPQIITIGLVWDSDHSDLAEDVIHSLGTCLKLGDLFFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDD... | 175 |
A9V9C1 | 2.3.1.286 | ACT_SITE 106; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MAGAGISTSAGIPDFRSPGTGLYDNLQKYDLPYPEAIFTLDYLRSKPEAFFTLAKELYPGNFDPTPCHYFIKLLQDKGVLLRHYTQNIDTLERAAGVRDDLLVEAHGSFAQAACIDCSHRHDTEWVKSQIDKDAVPRCESCGGIVKPSIVFFGEDLPRRFGQLVSEDFEKCDLLIVLGTSLTVHPFAGLATMPKPEVPRLLINRDSVGERDILNPDGFDFIRTNRDARYLGSCDDGVWHLARGLGWASDFEALLPEKWRERAPLPLDPTDRSSAEAKGGDDRSTDTEYESEAEAGVSSNGGSDTEDDTDAARHRQDVINA... | 58 |
Q4WCB5 | 3.2.1.52 | ACT_SITE 346; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MLISSICAVVLTVASSVAAVSVNPLPAPRNITWASSGPKRLAGHLTLRTDRGSNSQIIWQGWDRAWKTIVSLQWVPAATEAPISSFEPFPTATPSSSKSKRAPSSLQFVNVKVEDPKADLQHGVDESYTLDVKEGSDTIQITAKTVWGALHAFTTLQQIIISDGKGGLIIEQPVSIQDAPLYPYRGIMIDTGRNFISVKKILEQLDAMSLSKLNVLHWHLDDTQSWPVQINAHPEMVKDAYSVRETYSHADIRQIIAYARARGIRVIPEVDMPSHSSSGWKQADPKMVTCADSWWSNDVWQYHTAVQPNPGQLDIIYDKT... | 170 |
Q9NSY1 | 2.7.11.1 | ACT_SITE 180; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAK... | 99 |
Q9CKH9 | 2.2.1.2 | ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250" | MTQLDSLRSMTVVVADTGDIEAIKQYQPQDATTNPSLILSASALPQYAPLIDDAIAYAKTKSDCPRQQLVDAEDKLAVNIGLEILKIIPGRISTEVDARLSYDTQATIEKARKLIKLYNEAGIENHRILIKIASTWQGIRAAEVLEKEGINCNLTLLFSEAQARACAEAGVYLISPFVGRILDWHKANTGRQDYPAAEDPGVISVTQIYNYYKQHNYKTVVMGASFRNVDEIIELAGCDRLTISPTLLSHLQAREGELVRKLAFSGELKDRPQPLTESEFYWQHNSDPMAVAKLAEGICKFAEDQEKLEKMLLERL | 52 |
P0AEK2 | 1.1.1.100 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10001" | MNFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAVMRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGFSKSLAREVASRGITVNVVAPGFIETDMTRALSDDQRAGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGMYMV | 2 |
A0A1U8FGY6 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSKAVALLVVLLILVVFSGECYGELRVGFYKGKCGLTDVEGVVRNVVKTWFFTKKEKSIAAALLRLQFHDCFVNGCDASILLDGDNSEKKALPNKSVRGYELIDAIKDDLEAECEGLVSCADIIAMATRDAILLSGGKWYNVETGRRDGNVSLASNVNLPPPFISVSDSIKLFASKKLTPTDMVYLLGGHTVGIAHCSLFQDRLYNFNNTGGPDPNMSKWLLFGLRMKCPRGASFDNIAPLDVRTPSFVDNSFFEQIQRGNGVLQIDQQIALDELTKGIVDGIVKDPDFYTKFGEAMVKLGRVEVLTDEQGEVRTSCRVV... | 14 |
Q9YHZ5 | 2.7.11.1 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLDKRIVDVRLDQLEILKAKNGKEHFEKQYTMGNLLGSGGFGSVYSGHRISDGQKVAIKQISRDRIQQWSKMPGEVNPVPNEIALLQSLGGGSGSVPGHRGIIRMLDWFEIPGQEYLIVFEKPQHCQDLFDFITERGALDESLARRFLKQVIEAVQFCHSKGIVHRDIKDENILVDTRTGDIKVIDFGSGATLKDSMYTDFEGTRVYSPPEWILYHKYHALPLTVWSLGVLLYDMVCGDIPFEQDTDIVKAKPSFNKRISNDCRSLICSCLSYNPGDRPSLEQILQHPWMMESSVDNGDLQEESKIKPSL | 99 |
A0A0P0XPU2 | 4.1.1.17 | ACT_SITE 375; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MCNVCFTVTYHVSTMVGGSPMQAVLMAPGVKDKKVLAFKRGKGKDADAGVTALIRDIVAGGARSAFHVFDLAKVVDLHRGWRRALPDVRPCYAVKCNPDGAMLAALAALGAGFDCASRAEIEAVLALGVRPATIVYANPCKPEAHLEYAAEVGVNLTTYDSEEEVAKVRRCHPRCELLLRIKAPDSGDAKVDLGLKYGANPDEVLPLLRAAQREGVAVAGVSFHVGSGASRADVYRGAIEAAREAFDAAAALGMPPMRVLDIGGGFMAGRTFDEAAAVINRALERHFGDLPCVEVIGEPGRYFAETAFTLAARVIGKRTR... | 195 |
A0A067DMQ8 | 3.1.1.11 | ACT_SITE 158; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | QITQRIDVIVAQDGPGNYTKISDAILAAPSFRRKPYYIKIKEGNYTEYVVVGREKTNLVLIGNGINNTIISGNKSHGKDHLSTYQTATVAIKGAGFVAMNITFENTAGPDQETGQAVALVSEVDSAFYRCKLDGYQDTLYAKSNKQFYRECDIYGTIDFIFGDASAVFQNCNIYVRFLGGNVKTITAEGREKPEGNGGIIIHNCTITAAEDFSENRTSIKTYMGRPWRNYSRTVILQTFLDEIIDPEGWLEWQGQSVDTIYYAEYNNRGRGSKTTGRVRWKGFRITKRLEAENFTVKKFISGNKWIPSTGIPIFPGLL | 125 |
A0CQX5 | 2.3.2.26 | ACT_SITE 1144; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTATFVDQINFEFISIAISNTTKHRIIRINEDNFVVDPILTLPINTACYFESNAKSYKLQGQLNNFLKQHEEFKEVFLIFDDELDNQVHRAADRIIAENLGINNFIKGYEQFISNRNQNSINSQLQMYFGVQSISSIKISITKNLINKIEFIFAPLKHEGETLIKLKDQTLQVYSLLGENNIIYPEIDEVSFFFYNLIINFRDHHLESQITNDNQIQINFKRQPDLEFIYAFVDITLIAQYIHKLVCIIDKENEIKAINIQHTDEITTNNKYSLYSFVDDMIIFNYCKYYEFMFSNFILDYLNRKQINQIYKINQNITYS... | 65 |
A9T142 | 2.7.11.24 | ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | METSSGTPELKVISTPTYGGHYVKYVVAGTDFEVTARYKPPLRPIGRGAYGIVCSLFDTVTGEEVAVKKIGNAFDNRIDAKRTLREIKLLRHMDHENVVAITDIIRPPTRENFNDVYIVYELMDTDLHQIIRSNQALTEDHCQYFLYQILRGLKYIHSANVLHRDLKPTNLLVNANCDLKIADFGLARTLSETDFMTEYVVTRWYRAPELLLNCSAYTAAIDIWSVGCIFMELLNRSALFPGRDYVHQLRLITELIGTPEDRDLGFLRSDNARRYIKHLPRQSPIPLTQKFRGINRSALDLVEKMLVFDPAKRITVEAAL... | 104 |
Q5AM60 | 3.2.1.14 | ACT_SITE 151; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258" | MCHKMMNKFQQRLHHTTSTPLFKTCVYFSNWSVYQKKHFPQDIPIEYYTHIFYAFILIDEQTGKLKFSDEWCDLQMPQPSPNQSITGNLQQFYEMKKKNRHLKLIMSIGGWGTCHLFESVVSNDTKFDNFVNSTIEFAEKYGFDGVDIDWEYPKNSTQAAKLVELLARLRNKLNSKYIITVAAPGGSDNIEILKIQEMDKYLTFWNLMCYDFAGEGWSSKTAFHSNLFGNNGDNSLNASDVVQTYINKGVHPTKLILGMPMYGRIFHGVDRPEIGIPFTKERKSGCIEADVVDYNKFGDTFDYEDFDPRKVGALKYDSHS... | 158 |
T1FZ90 | 3.1.3.1 | ACT_SITE 84; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MFVCLFVCLFATNQPINQPTNKNRAKNVIMFLGDGMGLPTVAATRVYRQQGINPAEKKNYLFWESFPNLGLARTYNVDHSTPDSAGTATAYLSGIKANLGTIGVTEYVQFKKCSNMTGNRVESIVHKSIKEGKSTGIVTTTRITHASPAGCYASTPCRDWEDRVPDDATDCTDIAQQLILDDRNKDIKVILGGGLKYFLPDSYSNSTPPKVNGTRKDGKNLIQSWESYQTNQSRSYKLVFNKQALATVDAKNTDYLLGLFNADHMSFDADRSTTDEPSLADMTSKAIEILKKNDKGYFLFVEGCGKIDHAHHNTNAYRAL... | 141 |
A0A3B6QLW8 | 3.1.1.11 | ACT_SITE 378; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAPTSPTSAPRLLLALSLSLLLTSAHQLTTPSPPAPSKATAAGISPELVSTLQEALGAIKDVASIVSSFPIVGGVLGGDDLRLSSAINDCLDLLDLSSDELSWSMSAASPTTAGAGAAGRVGTGDAHADVRAWLSGALGNQDTCKDGLDDTDSMLGSLVSTGLQAVTSLLGDGLGQIAAGEEAASSARTSGHRGRGLGQGAPRHPHWLGPRERRLLQMPVGPGGMPVDAVVAQDGSGNHTSVQAALDAAPSERDDGRYVIYVKRGVYRETVEVNKKKWNVMLVGDGMGATVISGRLNYVDGYSTFRTATVAVVGKGFIAR... | 125 |
A0A0K9P1J4 | 3.1.1.11 | ACT_SITE 350; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTAAAATAVAFIIITIISGITSSLVPGDSLCFNSPNPSSCKLIVSDAIVSTDLSTSNHLHVVKKIIARSMNLSEVTISTATVDGRSSPAVADCTHLLELSFHRLFDSVTAIDAGEDEDVLTWLSSVLTYHETCLVGLRDSDLTPIKTGVMELKAMASAALAVFNSGKVTWEKDESYVSPSVAVIPPWITDEFPNGEHLHPDTVVDVTGKGSFRTVQDAVNAAPENSKRRYVIHVRKGKYKENVVVTRLKKNIMIVGDGMHRTIIIGHRNVVDGDTTFNSGTLISEGDNFILQDIAVRNIAGAAKHQAVAVRISGDKTVIN... | 125 |
B3RLP8 | 2.4.1.18 | ACT_SITE 328; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 382; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MTSSGLSKLENLFQEDPYLKPHRDNFVARYDRMKNILHHINEFMGGLDNFTQGYKYFGFNQLEDGSITYREWAPAAANLALIGEFNQWNRNSHQLKKNEFGVWEITLPPKSNGTPVIPHASLVKVEVTSIHGDKVDHISPWIKYAVPSRTYLAYDGIYWQTAQPYTFKYPKPKKPLSLKIYECHVGISSPEPKIASYNHFREKVLPRIADLGYNCIQMMAVMEHTYYASFGYQVTNFFAVSSRYGTPEELKSLIDTAHSMGITVLLDLVHSHASKNVLDGLNQFDGTDACYFHSGPQGMHPLWDIQRFLLSNLRWYMDNY... | 73 |
N1P212 | 3.2.1.28 | ACT_SITE 644; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:D6XZ22" | MKRIRSLWFNAEASYSNLNNSPSLRNKNSTGNNSRSKNYRSFSRFDLINSILLLMMLFLLAIFVTALYLTKSSRLTYSHASRAALFNPLGVISPSLGNHTLNYDPEARESSKKLYELLSDFNTAYYDDENMILGSNLFSKNTYSRQPYVANGYIGSRIPNIGFGYALDTLNFYTDAPGALNNGWPLRNHRFAGAFVSDFYCLQPKLNSTNFPELDDVGYSTVISSIPQWTNLQFSLVNDSKWFNPQNVTLDDVTNYSQNLSMKDGIVTTELDWLNSQIHVKSEIWAHRHIHPLGVVSLEISLNTDHLPSDFDSLDVNIWD... | 165 |
O35955 | 3.4.25.1 | ACT_SITE 40; /note="Nucleophile" | MLKQAVEPTGGFSFENCQRNASLEHVLPGLRVPHARKTGTTIAGLVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLVVGGVDLNGPQLYEVHPHGSYSRLPFTALGSGQGAAVALLEDRFQPNMTLEAAQELLVEAITAGILSDLGSGGNVDACVITAGGAKLQRALSTPTEPVQRAGRYRFAPGTTPVLTREVRPLTLELLEETVQAMEVE | 180 |
A0A9R0J6W2 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGEVILPFILIILVYAASATNPVPKGLSYNFYDKTCPQLEDTVRAALNPVFITDPTTAPALLRLMFHDCQVQGCDASILIDVSDSAPSKPSELGAKKNFGIRKRELINQIKSRLEIECPGQVSCADIIVLAARESVAISGGPRIKVPLGRRDSLSASSSEVADASLPSSDIGVDDTLSLFAKLGMTTQETVAIMGSHTLGITHCLNIMDRLYMPSNAKASSMDPRFEALLKFSCPEFTPLSQNTSFVFNDPSTFIFDNLYYQNSLQRRGVLRIDAELPLNIKTAGIVEHFAANDDDFFQEFTSAFLKLSYAGVLTGNHGV... | 14 |
Q7UVB9 | 1.1.1.49 | ACT_SITE 239; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MSHTIVIFGASGDLTSRKLVPALFRLFSRGRLPDSTRIVGVSRSPYEHSEWRKSLRETTAKFVGKSFSEEAWESFAPNIYYQPGDIKDAESFQSLATFLDEIEEGKSTGRVYYLSTMPQLYEEAIQQLGAAGLACDKTGPRRVIIEKPFGTDLKTAQRLNESIHNVFREDQIYRIDHYLGKETVQNIFALRFANSIFEPLWNRNYIDHVQITVAEEVVIGRRAGYYDNSGILRDMFQNHILQLMMITAMEPPAKFDAALVRDEKVKVLHSVRKMTGGDFASQTVRGQYDGYLQEEGVPANSQTETFAALKLYCDNWRWQG... | 6 |
F5HMB9 | 3.1.4.11 | ACT_SITE 328; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MTKKFEFNWQIPVPEPLLTGCVFDRWTEEKDNNELEPNCMFKVDEYGFFIYWKSEGREGDVIELCQVSDIRAGGMPKDMKLYNQLCNKHGENVEEKSLTICSGTDYININYQHVVCPDAATAKLWQQGLRDITHNIKMNNVCVWTNLMKHWMRLGFLVDPRGKVPVKVVARTFASGKTEKLVYQILSDLGLPSGKNDVIEKADFTFEKFYELYHKICPRNDIEELFRSITQGKANAINLDQFINFLNEKQRDPRLNEILYPLYDEKRALEIITTYEQNDEAREAKTLTKDGLIRYLMSDENAPVFLDRLDIYMDMDQPLS... | 153 |
Q9LW62 | 2.7.11.1 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDHVIGGKFKLGRKIGSGSFGELYIGINVQTGEEVALKLEPVKTKHPQLHYESKVYMLLQGGTGVPHIKWFGVEGNYNCMAIDLLGPSLEDLFNYCTRSFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFIRGSLPWQGLKAGTKKQKYEKISEKKMLTPVEVLCKSYPSEFTSYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDWTILKYPQSGSISKPRPNPKPALDPPGPSAE... | 99 |
A8R7E6 | 2.7.11.1 | ACT_SITE 441; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKLKISLIAPILLLFSFFFAVESKCRTSCPLALASYYLENGTTLSVINQNLNSSIAPYDQINFDPILRYNSNIKDKDRIQMGSRVLVPFPCECQPGDFLGHNFSYSVRQEDTYERVAISNYANLTTMESLQARNPFPATNIPLSATLNVLVNCSCGDESVSKDFGLFVTYPLRPEDSLSSIARSSGVSADILQRYNPGVNFNSGNGIVYVPGRDPNGAFPPFKSSKQDGVGAGVIAGIVIGVIVALLLILFIVYYAYRKNKSKGDSFSSSIPLSTKADHASSTSLQSGGLGGAGVSPGIAAISVDKSVEFSLEELAKATD... | 99 |
A0A1B6QCB0 | 3.2.1.1 | ACT_SITE 179; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 204; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGNRHLCCLSLLLLLGLASGQVLFQAFNWESWKQSGGWYNLLMGKVDDIAAAGVTHVWLPPPSHSVSTQGYMPGRLYDLDASKYGTAAELKSLIAAFHGKGVQVVADIGGTPDGRLDWGPHMICRDDTIYSDGTANLDTGADFAAAPDIDHLNDRVQRELTDWLLWLKSDLGFDAWRFDFAKGYSAEVAKVYVDGTAPSFAVAEIWNNMAYDGNNKPEYDQDPHRQALVDWVDKVGGAASPATVFDFTTKGILNAAVEGELWRLIDPQGKAPGVIGWWPAKAVTFVDNHDTGSTQAMWPFPSDKVMQGYAYILTHPGNPC... | 157 |
A9UW79 | 1.11.1.6 | ACT_SITE 54; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 127; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MSKCPYTTDAAGHPLDDQNAALRAGSTGPLVVDPRLYEHNAIFNRERIPERVVHANGAGAFGTFRVTKDVSQYTKASFLSSVGKETKIAARFSTVAGERGFADADRDVRGFGVRFYTDEGNFDLVGNNTPIFFVRDPNKFQDFIHSQKRNPQTDLRDWEARWDFWSLSPESVHQVLILMSDRGVPRTYRHEHGYGSHTFSLINDKDERVWCKWHMRTNQGYETLAEEEAQKVRGANPDSHKDDLFHAIERGEYPSWKVCLQIMTDEQAKKMDFDIFDLTKVWSHKEFPLIEVGEMTLNRNPQNYFAEVEQLALSPGNLVP... | 13 |
A0A1U8GQ16 | 5.3.1.8 | ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEEVNGGALLIKLICCVKNSDWGIIGRESTVARLYYRNARIGIDQDHPYAEFWMGTHESGPSYVRGGEGGGKVTLKEWIERNPSVLGDTVLKKWGTDFPFLFKVLSVAKALSIQAHPDKDLATSLHKEQPSVYKDDNHKPEMALALTQFEALCGFVSLEEFKVTVRTTPEIVEVVGNAKAEQVLNLHQHDGKEEIRLLLQSVFTDIMTVRKDVIAEVLSKLISRLNFEGQARHLTDKEKLILQLEKQYPDDVGVLSAYLLNYVKLNPGEALYLGSNEPHAYLYGESVECMANSDNVIRAGLTPKNRDVEILCSMLTYKQG... | 214 |
G1KPQ7 | 2.7.11.30 | ACT_SITE 366; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1" | MDGHLWREKSIFHLFFLFPDEDHLSKLLNGKIKFPTLCKFCDVKLTNCKNEGQCKSHCNLTSICEKKTEVCAAVWRKNDENITLETICHDPSQKLHGHELTDYNSKKCIMSERRETGGLLYMCSCDEEECNDVLIFSPENSPTERVIDVISKVALISLVPLLVSAIAVSFIFYCYRIQRRRKLNKAWEKNVKSRKRKDCSDVCAIMLDDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFSYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTDLGKQYWLITAFHSRGNL... | 106 |
A7EF73 | 3.1.3.48 | ACT_SITE 105; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MNTEPSRIPGEDELYVGGIVSLTENSLQKNNITHIVSVLKYDFKNFNINWNKYKHLQIEVDDVEDENLLGAFETTGAWIEEALKGNGQSEGEEGEKKRGAVLVHCAMGRSRSVTILIAYLLRQYPSLTPAIALAQIQQTRPFAEPNDGFMAQLQLYHEMGCPRNIDEQPKYQRWLYQREVELAVATGGRPDWVRFEDEVEQDGPKPDGKEKEIRCRMCRRTLATTPYLILHTPNPRAASSPTSLINPQTTPISSLPPTPHHSACTHHFLHPLSWMRPELELGNLSGRLECPNQKCKAQIGKYAWQGMRCSCGVWVCPAFS... | 149 |
Q2G1S3 | 6.3.4.4 | ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00011"; ACT_SITE 139; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MSSIVVVGTQWGDEGKGKITDFLAEQSDVIARFSGGNNAGHTIQFGGETYKLHLVPSGIFYKDKLAVIGNGVVVDPVALLKELDGLNERGIPTSNLRISNRAQVILPYHLAQDEYEERLRGDNKIGTTKKGIGPAYVDKVQRIGIRMADLLEKETFERLLKSNIEYKQAYFKGMFNETCPSFDDIFEEYYAAGQRLKEFVTDTSKILDDAFVADEKVLFEGAQGVMLDIDHGTYPFVTSSNPIAGNVTVGTGVGPTFVSKVIGVCKAYTSRVGDGPFPTELFDEDGHHIREVGREYGTTTGRPRRVGWFDSVVLRHSRRV... | 253 |
D5H2W5 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00318, ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 338; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00318, ECO:0000256|PIRSR:PIRSR001400-1" | MLKSVIENVHALEIFDSRGNPTVEVHVTLSNGVVGKAEVPSGASTGENEAVELRDGGSRLGGKGVSKAVNNVNTEINDALKGMDPYNQPKIDKTMIDLDGTPNKGRLGANAILGVSMAVAVAAANDARLPLYRYLGGTDLEMPQTFHNVINGGEHADNGIDIQEFMITPVAKTSFRDGFEKIVNVYHTLKKVLEDMGYETGLGDEGGFAPNMKNSEEALKALHESIIKAGYKPGEDIAIACDCAASYFYNKDDHKYHLEGKVLTDEELADYYDKLLDEFPELISMEDPYDENDVDGMVKFTKSHKDRIQIVLDDFICTNP... | 200 |
E9G8C7 | 2.3.2.26 | ACT_SITE 850; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAENGKNDGGNILSAGDSQTLDKRVAARQLIKRYYFQLTEGCGDSNCNNEHCASSKKVQNLSPNQAAAQALDLFARKGRLCVGTGKNELPSTLFPEITPASTSAISDQQLLKISNSNLKQGLWVAPALSVSGHTANDKSGISKPTKLTETNFKQIVDNCKEYGIYSKLVHTLGHVFANPELLGKSFITQGNNSCTSTLGHGQLSKEQLRSMEVDLDKDKDSQEAVAEPRLQDVGQEVSVDICCVRRSFEALSSIEPQNYESALVHALILLCETIELDMKFGRQKAEVNLLNVFVIVFELPWLGTGDYFESVLPTLCRACA... | 65 |
Q5P7I0 | 1.3.3.3 | ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MGAPDSRVVRQHLLDLQSGIVAVLERFDGGRFREDAWQRPAGGGGITRVIEEGRFFERGGVNFSHVIGGAMPASATAHRPDLAGRTFEAMGVSLVLHPRNPYCPTVHMNVRFFIASHPEAAVPPPAAAPVWWFGGGMDLTPYYPYEEDVRNFHRACRAAVLPWGGEPEYRRLKEWCDRYFFLKHRNEPRGVGGLFFDDLGADGKTDFDAAFGLARSVGDAFLDAYLPIIERRRDVAYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPVVKWRYDWQPEPGSAEARLYDEFLAPRDW | 27 |
A0A072TVL2 | 5.3.1.8 | ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEDSNPNNSLQKLHCSVKNYDWGLPGQLSQVAKLSELNSGFKFDPMKPYAELWIGTHDSGPSFLVSDDDGQRISLKDWIFDNPDLLLGHKVVKKWGSDLPFLFKVLSVGKALSIQAHPDKELARMLHKLHPDVYKDGNHKPEMALAMTDFEALCGFITLKELKAVIHTVPEVVNLVGASNANLVLETSDQNEEKVKPVLQAVFTHLMSASKEIVTDAVNRLINRLHEESEMRHLTEKELLVLRLENQYPSDIGVIAAFFLNHVKLNPGEALFLGANEPHAYLSGECIECMATSDNVVRAGLTPKFIDVPTLCSMLTYKQG... | 214 |
H2MFF1 | 3.1.3.48 | ACT_SITE 88; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MLLVDPGVYIGTAADLNDCQALAAASVTHILSVESVDPGPQIPATGNFIRKWINALDEETTDLLSYLDACNIFIDEAVKGGGATLVHCHAGRSRSATIVTAYLMKKHHLAFPEAYQRLKSVKQDVQVNRGFEEQLQLYESMLCQVDTSSALYKQYRLNKIAERYPELQQVPRDIFANDPAHSSSSEVSYRCRKCRRTLFRGSSILSHPVGDGASAFSHKKTSNLSGEVQCTSYFIEPVQWMEQALLGVMNGQLLCPKCSSKLGSFSWCGDQCSCGRWVTPAFQLHRNRVDEIRQINSTK | 149 |
A0A2R6XQ96 | 3.4.21.92 | ACT_SITE 163; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 188; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MEALAVKTPVPVVASRGLSQGCSSTSGLASLELCPRFCKLAGFRAEQKWSQTRKIARSRVVASLPGLDTRSFYAPEAPRLMDLDPTTNLLQQRIIFLGSQVEDMTADIIISQMLLLDAQDPTKDIKLFINSPGGSVTAGMGIYDAMKLCRADVSTTCFGLAASMGAFLLAAGAKGKRYCMPNARIMIHQPLGGAGGSAIDVGLQVREMMYHKRKMCKIMSRLTGNSEEKIEEDTDRDYFMNAWEAKEYGLVDVVIDDGKPGLVAPLGEVKEPPKSRVWDMWTVKEGKARKELPTEEIYEKSSSDVSEPVEST | 179 |
A0A2C9VH06 | 3.4.19.12 | ACT_SITE 94; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 97; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 297; /evidence="ECO:0000256|PIRSR:PIRSR013503-1" | MQNQNHNQNQNLEGQLPDEQTASQFEDWANFGDDDIMQQHSAIRSAEADKIPFLGEKEPISALAAEYESGSPILIEKIKVLAEQYVAIRRTRGDGNCFFRSFMFSYLEHILETQDRAEVDQIKRKVEECRKTLQSLGYADFTFEDFFALFLEQLDCVLQGNESSISHDELLNRSRDQSISDYVVMFFRFVTSGEIRKRSEFFEPFILGLMNATVEQFCKSSVEPMGEESDHVHITALSDALGVPIRIVYLDRSSCDTGGVSVNHHDFIPAADDLPNSTSGDSVTKNPFITLLYRPGHYDILYAK | 175 |
F6V551 | 3.1.3.1 | ACT_SITE 168; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MWLQTQAPQHPESRLATAGSQEILNNSAQAACSAAGTLVSRVSRLPASLSSRHPTGMQGAWVLLLLLGLRLRLSLGVIPVEEEDPAFWNRQAAQALDTAKKLQPIQTAAKNLIIFLGDGMGVPTVTATRILKAQMDGKLGPETPLAMDHFPYLALSKTYNVDRQVPDSAGTATAYLCGVKANYQTIGVSAAARYNQCNTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRSWYSDADMPDEALKEGCQDIATQLISNMDIDVILGGGRKYMFPKGTPDPEYPNDASQNGTRVDQRNLVQEWLAKYQGA... | 141 |
A0A067G592 | 3.1.1.11 | ACT_SITE 339; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLNFCKLFIFIFLVSAVSLSSSSNAGSEYSQAECLKVPASSFMSSLKTTVDAIQQTVLISLISLLMSSAGPSLLPKIPTGRHNGSGDLSSDLRTWLSAALINQETCIDGFDGTNSIVKGVVSGSLNQISSSVQELLTMVHPSPSQWSNEGSSSNSGGKSRGGGGKSSGQFPHWFKREDRKLLLVNGVQADVVVAADGTGNFTKIMDAVLAAEDYSMKRFVIYIKRGVYKENVEIKKKKWNLMMVGDGIDATIISGNRNFMDGWTTFRSATFAVSGRGFIARDITFENTAGPEKHQAVALRSDSDLSVYFRCAIKGYQDSL... | 125 |
A0C5Z6 | 3.4.19.9 | ACT_SITE 130; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 242; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MLRIIITSLFISSVICANNKPTIGILTNPSDMKDYDKSLYSYFPSSYVKWIEQAGARVIPIHWDSSYDEITVILSQINGVLFTGGDADLYLNNTQPGFTFNKFTDTASFIFQKVIQFNKAGKFYPLLGICQGFQLINYIASSYYEVLTRMTDDLGRQRLLEIVPEEDSYVLNSIDKSTLEYLKNVDGPYYSHNWGVVQQTYEKSYSLGAFFKITGYGRDGVNLKYIAICEGREVPIYGYQFHPEKHPFEWITKATHDVQHITYSQELAMAFIAMARKNDNFISDEELSQYIIYNYKQVNRMHVPNTSFSQVYLFDRNRNE... | 176 |
Q5AUT0 | 3.2.1.39 | ACT_SITE 128; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 239; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MFTKTQILALALSIASAEAVSKGFNYGANKPDGTLKVQADFEAEFRTAKNLETTSGFNSARLYTMIQGTGSTPISAIPAAIAEETTLLLGLWASGGNMDNEIAALKAAINQYGDEFAKLVVGISVGSEDLYRNSEIGVQANAGIGIEPEELVSYIQRVREAIAGTALSGAPIGHVDTWNAWTNGSNAAVAEAVDWLGFDGYPFFQNTMQNSIDDAKALFDESVQKTKAVAGNKEVWITETGWPVSGDSQNLAIASVENAKQFWDEVGCPLFDNVNTWWYILQDASGSSVPNPSFGIVGNTLSTTPLFDLSCSASSKKNSS... | 167 |
K4AK98 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAAFRLVVVVTCALLLASACQGLHVGYYKKTCPRVEHIVRAEVKKFVYKNAGIGAGLIRMLFHDCFVQGCDGSVLLDPTPANPEPEKRSPPNFPSLRGFEVIDAAKDAVERACPGKVSCADIVAFAARDAAYFLSKLKVKIDMPAGRLDGRVSRASEALDNLPPPFFNVSELVAAFAAKGLGAEDMVVLSGAHTVGRSHCSSFVADRLAAPSDINAGFANFLRRRCPANPTPANDPTVNQDFVTPNALDSQYYKNVLGHKVLFASDAALLGSPETAKMVRDNAYIPGWWEDRFKAAFVKMSRVEVKTGKQGEIRKNCRV... | 14 |
Q8T2T7 | 5.6.2.1 | ACT_SITE 361; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383" | MTKRILNVAEKPSAAKEIAAILSNKRATVREGFSKYNKLWDFKYNILNFNDCEMTFTSVTGHLMEIDVVEQFKPWASCDPIQLFDAPIRKTVPSDKEPLKKTLEREIKKADILILWLDCDREGENIAFEVLEVCKNAKKKFEFYRAHFSAIIPREIDRACKNLAKPNEKDSIAVDTRMEIDLRIGAAFTRFQTLYLKKFKIISNSDNQPKTTTPANGNILNNSNNNSSGKEIISYGPCQFPTLGFVVERYFRIVNFKPEDFWHLSVVHEKMDTSSGKMIPVTFSWCRNRLFDYTAAFILYEKCLDNTEATVVDVTSKESR... | 221 |
K7K5X8 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNNLTLASILTVISALLLFLGTTHFTNTPITITRAPDQKHLHHFQKHIQVVAKSTCQGTLYPDLCVSTLATFPDLATKSVPQVISSVVNHTMYEVRSSSYNCSGLKKMLKNLNPLDQRALDDCLKLFEDTNVELKATIDDLSKSTIGSKRHHDLQTMLSGAMTNLYTCLDGFAYSKGRVRDRIEKKLLEISHHVSNSLAMLNKVPGVKKLTTSESVVFPEYGNMKKGFPSWVSSKDRKLLQAKVKETKFDLLVAKDGTGNFTTIGEALAVAPNSSTTRFVIHIKEGAYFENVEVIRKKTNLMFVGDGIGKTVVKGSRNVV... | 125 |
A0A059AQK1 | 3.4.25.1 | ACT_SITE 127; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MDKENFIKSESHDSDSLFILFCHHLISDLLIPYSHLNLEEKQSLKQNRTCRDAFPLSRPSPAFSGGSVLRRLAAPRVSPPAGLLKSQMSKATIDLPPKGGFSFDLCRRNDMLSKKGVRPPSYRKTGTTIVGIIFQDGVILGADTRATEGPIVCDKNCEKIHYMAPNIYCCGAGTAADTEAVTDMVSSQLQLHRYHTGRESRVVTALTFLKRHLFNYQGHVQAALVLGGVDFTGPHLHTIYPHGSTDTLPFATMGSGSLAAMSVFESKYREGLTKDEGINLVSEAICAGIFNDLGSGSNVDICVITKGHKEYLRNHLLPNA... | 180 |
Q4WU06 | 2.7.11.1 | ACT_SITE 794; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MPHKQKKNPSNVHKNGSPRAERKQSTSNTIPLAQPGLATTNYREIHQNEAEALRSIYGDDFEEIEHRPSAWQQSADVAFKLHLRASSNPEVRVDLLVELPTTYPKTYPNLSLGNSENIRHRARLKIQDIIRNKPKELLGSEMIYELAVSIQDVLEDVAQAQAQDKDLPSLEEERMVQEAAANQRAELERQEELRKQEAATAEEERALQQLLEDKLRERTKARLSRRKSRSSGTGLSGSIDAVDQFPDAITFDPPLIINDTNEQPLAFSAVFGKTLLQSSPGKQTFTVRPVVSGSRSHAPLIVLKELSLDGNGTAPICYRE... | 99 |
I1KTG6 | 3.1.1.11 | ACT_SITE 390; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MMASSSLFYLSLSLILTLTSAARHKPHPSPAKPPAKPAVTTATSPAIQQACAATRFPQQCEASLSQSQNLPPNPNPTPLQLLQSAIALSSDNLATAQTMVKSLHDASADSRNRTVAAATCIEILANSHYRISLASDALPRGRTKDARAWLGAALAYQYDCWNSLKYANDTEMVGKTMLFIDNLETLSSNALSMAFSFDAFGNDTASWKPPVTERDGFWEAVGSGGPASAGGVPPNLTPDVTVCNNGGDGCYKTVQEAVNAAPANGTKRFVIYIKEGVYEETVRIPLEKRNVVFLGDGIGKTVITGNGNVGQQGMTTYNSA... | 125 |
A0A804IE41 | 3.1.1.11 | ACT_SITE 221; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDQEVVSAGQYLACHRDRILCSLPGKPRFFSPPCYSYCACLLPLIWCSLAPYSDTCTHYVSQSMQQMSIHAAMEHAILAREQILLGGLEGAARRGDVVADLVVAKDGSGDFGSIKEAINEADLMLVGDGIGKTVVTGSRSVAGGSTTFNSATVAVTGDGFIARGITFRNTAGPAKRQAVALRCNADLAVFYRCSFEGYQDTLYAHSLRQFYRECDVHGTVDFIFGNAAAVLQDCNIYVRRPMSKQQNTITAQGRTDPSQNTGIVIQHCRVTAAPDLRPVQGKFRTGGFALNTLYYGEYKNTGPGSDTSRRVRWRGHHVIT... | 125 |
A0A072UTA3 | 3.1.1.11 | ACT_SITE 327; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTTYATILFLFFAMSTTTSFCLQEMEVLQMAKTQVSQAINWVDNSMKLHGLESMSISLNQTSVLALRDCAKLYEESEFMLNNMMVEKSSYTKEDAIIWVSAMMTNHKTCLDGLEEKGYVQANQVLDRNLTSLLGQTLVLYSNNKIKVKEQPQRSTILEENDGLLDSWSLANHRADFTVAQDGSGSHRTIKEAVDALASMGHNRPSRAVIHVKAGVYHEKVEIEKKLHNVMFVGDGIDKTIVTGNRNVVHGSTTLNSASFDVSGDGFWARDMTFENTAGPENHQAVALKVSSDLSVFYRCSFKAYQDTLYVHSNRQFYRDC... | 125 |
A0A9J7MYY7 | 2.7.11.1 | ACT_SITE 906; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MADTEETYEERQENEVELLSAVYVDDFKDLRDQDAWKIKRAPEVCLTLVPQQSMHGTADVYAKVDLHIKCPPNYPDVEPELDLKNSKGLSDDNLRQLKHELHKMAQQNLGEVMLLDLAQHVQTFLHAHNKPPRGSFYEEMMSNKRRQEEKVAREIQKKLDVQKRIQEKERRELEEEITRRQEIIKEEMRKRRNQKMEREDEIDNGNSSSEQVSPKTSLSESPSTENLSQRRQGSPIKETPTRTRSQSGGGERQQSQDRLTVIRRQRSISESNSEPLEHQKYTGPQVLVFTTRGERSVCKGRCIGAGPRSSGSLVYVGMDN... | 99 |
Q8R5X8 | 5.4.99.25 | ACT_SITE 38; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MEGIIVINKPKGITSFDVIRKLKKFLKTKKIGHTGTLDPLAIGVMLVCVGKATKLASDLEAKDKVYIADFDIGYATDTYDIEGKKIAENIIEVSKENLEQSLKKFIGNIKQVPPMYSAIKIDGNKLYHLARKGIEVERPERDITIEYINLLDFKDNKAKIETKVSKGCYIRSLIYDIGQDLGTYATMTALQRKQVGEYSLENSYSLEQIEEMTLNNNFKFLKTIEEIFSYDKYNLQTEKEFILYKNGNTVKIKENLENKKYRIYFQDEFIGLANIENNNLLKGYKYY | 218 |
P9WI83 | 2.7.11.1 | ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSR... | 99 |
C4M9I9 | 2.3.2.26 | ACT_SITE 629; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METPQITNKKYYINRICFGCGNDQCNNKYCKSSSSFVSPLNIEEEAQQLEINKTPLCTLRCSLQRFLSLKEEQTSDRLETLLYELYSTPESIVESFVEEGVFDVVKGWELIDYILKFQPSLYQSVLNAHLKILEIVKIKPINIQSIIVTLASPIFAENDEMGEFCSIIQKLSSFIVELQVFLRKMTPKQFLCVLGNIEQFISLRVILKKNTVHDEDILFKVLTLLKTFYSINDDKRFVDENKFYNEILATQRQFPRDIQYFYSNKNTSLLYFPFIIPVDYKMKFLHKEAKQERGQSTVQAFTESITRGEEQKLNLNIQVR... | 65 |
I1HEP5 | 3.2.1.14 | ACT_SITE 116; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MAFHEPASANCDIRFVLSVAVFLAVAAASSVVSVDARYGGGAAAGQYCSSVETIVSEELYSSLFLHKDDAACPGKGFYTYASFIRATRKFPEFGATGDLCTRKREIAAFFAQISHETTGGWPAAPDGPYSWGLCYKEEIKPQSSYCDATDKQWPCYPGKSYHGRGPIQLSWNFNYGPAGRALGFDGLRNPEQVSNCSDTAFQTALWFWMTPRQPKPSCHQVMVGEYCPSRADNVANRTAGFGLVTNIVNGALECNITDDARVNNRIGFYRRYSQVLGIDVGPNIDCAHQLPYN | 158 |
A0A2C9VY61 | 3.2.1.143 | ACT_SITE 270; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 288; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 289; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | METREDLKSLLPFLPLVVRSSSLFWPSRVVEALKALSEGPDINNVNSGESLFAAISDIRNSLSLCAEPLAPSAPEGYSLFFDELMSRAESTKWFGEVLPALANLLLRMPSLLQSHYENADKFFNGVTNGVRTSLRLLGPQVAGIVFLSQELIAAFLACAFFCLFPVTDRGAKHLPTIDLDHLFEDLYENYSEKQENKIMCILHYFERICSCTPGGFVSFERKVLPWEQFPTGISYPGADFWNKSVAPLCSFEVHNLGFIEDQSNGALEVDFANKYLGGGALHRGCVQEEIRFMINPELIAGMLFLPRMEDNEAIEIVGAE... | 159 |
Q38E77 | 2.1.1.33 | ACT_SITE 143; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MTSTTQPKWTRLPIRTRPHRNPLAENSDNHPDCPAELQEQCTTLFPGMDNPVITLVDVGCAFGGMLFSLAPDFPDMCMLGLEIRPKVVEFAQNKVMKLREGAATDGTSHHYRNVWFEQLNVMKFGSNCFNKGQLQALFFCYPDPHWKRKNVRRRIISPGLVQEYAYWLKVGGFLFTVSDVEELERWMVTCLDGCPLFRQLSQEELAGNEMVRKMLDYAANSSEDAQRTTRKGLQKHYAVHVRVP | 45 |
Q6CAG9 | 3.4.21.89 | ACT_SITE 50; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367"; ACT_SITE 89; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367"; ACT_SITE 114; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367" | MVNFGAQSIRQTLVQLLGFAAIFTSSYMFYKGLSIVANSESPLVVVLSGSMEPAYQRGDVLLLWNRQKHVDVGEVVVYNIDGRTTPIVHRVLRSHASDNKQLLLTKGDNNAVDDVSFYGGRNQYLDREKEVVGVVKGYLPLVGYITILLAENQYFKYGLLGITGLLAFIQGE | 178 |
A0A3B3H649 | 2.7.10.1 | ACT_SITE 669; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MDLWFHSIRICWWRVLFLMSIFQDYLSSMLDCPPTCSCSQTEIYCNKSDNGRFFPLLALQDTGTNGTTTDIAELFKNISSIHIENWTGLETLRDVDMELYTGLQRLTIMNCRLKVIQPRAFAQNPHLRYINLSKNPLTTLSWQLFKHLQLSELRLDGVVFDCGCDIRWIQLWQQRGEAMLHTQELYCRDGASKIRLGNMYIEKCDLPEISVSHSSVLVREGDNVTVSCNGTGLPLPEVDWTVGQLNSINTHMSNVYWPNIHSIDLNLFNISRDDNNFQLSCIAESVVGMTNSSIQLNVQFPPVIIALAEPQQRLDTCIEF... | 97 |
Q8EHY4 | 1.11.1.6 | ACT_SITE 54; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 127; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MSQQYLTSQSGSPIADDQNSLSAGERGPLLLQDWHLIEKLAHFNRERIPERVVHAKGTGVYGTFTLTKDLSDYTIADHFNGVGKQTETFVRFSTVGGEMGSADAERDPRGFGLRFYTARGNHDIVGNNTPTFFLRDGIKFPDFIHTQKRNPLTNLKDPQAMWDFWSLNPEAMHQVTILMSDRGIPANYRQMHGYGSHTFSFWNAKGERFWVKFHFKSQQGVVNLSNEQADKLKGIDPDSSQRDMVVAITDGNFPRWTVNVQIMPEADANTYHINPFDLTKVWPHGDYPLIEIGVLELNRLPQNYFAEVEQVALAPSNLVP... | 13 |
A0A8V0X2Q8 | 2.7.10.1 | ACT_SITE 1214; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000617-1" | MYFDRLNLTMKPVTAYPSGIILFLFALLQRSHGQCKEAAKKSEMNLNVKYDLPNFITETPIQNVVLYKHHVYIGAVNKIYVLNETLQNISVYKTGPILESPGCAPCEDCKDKANLSNSVWKDNVNMALLLETYYDDQLISCGSVSGGVCHRHIIPPDNPADIESEVHCMYSPQVDGEADNCPDCVVSTLGTKVLVTEKDRFVNFFVGNTVTSAFQPPHVLHSISVRRLKETQDGFEFLTDQSYIDILPQFRDSYPIKYVHAFEHDHFVYFLTVQRESLDSQTFHTRIIRFCTLDSEMRSYMEMPLECIFTEKRRKRSIRK... | 97 |
F1QLR7 | 2.7.10.1 | ACT_SITE 1205; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000617-1" | MTIHYSEAASILIILQSLWWGLNCQCEEPIESSKLDLSVTYDLPYFVSDTPIQKLLEINGTVYVGAVNRLYALSKDLKKKHEYKTGPVHEGPDCKTPTDQCSGCENKPRNINNTNMALLMETFYDLELFSCGSVGNGVCSRHVLEDGPLGAEVTCMYTKKNEGSSHGCPDCLAGPAGTQILNIMSGRVVRFFVANSEPLESNGPRLHHTISIRKMRETQDGFEFFSDQSYMDLAPSLRGNYPLHYVYSFQSGPYVYFLTVQREGGNSKAFHTRIVRMCSSDSEILRYVEMPFECIYSERRRKKRSAQVVFNVLQAAHVAK... | 97 |
I1H555 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGKVAATLVVPALLMALAFCQAAGYYEPPSPGKCGLTVGYYHESCPHAEDIVKGVVAEAVRRNPGIGAGLIRMLFHDCFVEGCDASVLLDPTPANPQPEKLSPPNFPSLRGFEVIDAAKDILEKACPGVVSCADIVAFAARDASFFLSKRGRGVAFQMPAGRLDGRVSIASRALDLLPPPTFGLAQLVDNFAAKGLSAEDMVVLSGSHTVGRSHCSSFVPDRLAVPSDIDPALGTSLRGQCPASPSPADDPTVVQDVVTPGKLDNQYYKNVLAHKVLFTSDAALLASAETAKMVLDNANIPGWWEDRFEVAMVKMASIEV... | 14 |
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