Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q9KPM0 | 2.4.2.1 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01627" | MATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY | 75 |
A8XDJ2 | 3.4.19.12 | ACT_SITE 84; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 244; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 268; /evidence="ECO:0000250|UniProtKB:Q96FW1" | MVNDTSENQPTTAGIVTTTEDELILQDQQMKRIEDEQKASPLVGEKMPCATLVSLYDQETAPAFFEKANELAKVYSHIRFIRGDGNCFIRAIQVGLVEILLNDKERLVKFIASCKEWTERLVKLGFPDWTCTDFCEFFIEFIEKVRDGIHQKEDVFRIFNDDNTANYLLMFFRLITSGYLKEHAAEYEPFLDEGMSLAQYCETEIEAMWKESDHLGIIALVRALNIRIRIEYMDRNAAPNGGTHHNLPDGHDNATFTPDITLLYRPGHYDLIYKAPAETSKPALPPVA | 175 |
Q54H45 | 2.7.11.1 | ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKVQIVFFSITVFIFVLFLLSVESNTKIKIVPSFLENSNEIEDLYINLDSDSKSSEHTTSSSSSSNSKNKGDSSSSSSNSGSSSNSIISGDSNSKDAPTTSSDSLSPATPIPTDGLLSASTYVTFTGGKVLCENITFCPNGYMYSSDYACNYDIVQNDPATHRGDWNDGIKMFEDPLPKNTTIDQVEGISFTISGAVGCQVTSSATTLEFYIQDLLVLTNTTSRYDICTCGSCYVTFGTEVYKYNMLGYNITGENKFQIQVSVNSMCATTIGITLYYKPPTITPTPTITPTPTITPTPTITPTVTPTATPSTTPSTTPTT... | 99 |
P34760 | 1.11.1.24 | ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000305|PubMed:8041739" | MVAQVQKQAPTFKKTAVVDGVFDEVSLDKYKGKYVVLAFIPLAFTFVCPTEIIAFSEAAKKFEEQGAQVLFASTDSEYSLLAWTNIPRKEGGLGPINIPLLADTNHSLSRDYGVLIEEEGVALRGLFIIDPKGVIRHITINDLPVGRNVDEALRLVEAFQWTDKNGTVLPCNWTPGAATIKPTVEDSKEYFEAANK | 12 |
A0A078J162 | 3.1.1.11 | ACT_SITE 368; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSSSTLLHHKSSKTLMILLIINFVNLIQTTSAVTNSNSNSHFSRFSRHGSSSSRTKQGFLASVQASMNHAILARSLAFNLTLSHRTTQVHMVDPIHDCLELLDDTLDMLSRITMMRDKASSDDDYEDVHTWLSAALTNQDTCQQSLQEKSNSYKHGIAMDFAARNLTGLLTNSLELFVSVKSKGRRLLSEQAHYPRFVTWLKERRLLEASVEELKIDAVVAADGSGTHKTVGEALAASLASSGGRTVIHLKAGTYHENIKIPTKQKNVMLVGDGKGKTIIVGSRSNRGGWTTYQSATVAAMGEGFIARDITFVNSAGP... | 125 |
P25868 | 2.3.2.23 | ACT_SITE 92; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MATAPARRASSSRSSSEISRTTPSMGFQLGFVDDSNVFEWQVTIIGPPETLYDGGYFNAIMSFPQNYPNSPPTVRFTSEMWHPNVYPDGRVCISIHPPGDDPNGYELASERWTPVHTVESIVLSIISMLSSPNDESPANIEAAKDWREKQDEFKKKVRRAVRKSQEML | 64 |
Q0USB7 | 3.1.3.48 | ACT_SITE 92; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MALIDKVPGDLQLYIGGMFTLRRREALQQANITHVVSVLRLPLDQDLFSPFKEHMVVEVDDVDDENLLEHFPATNRFIKAGLNGGGGVLVHCAMGKSRSATVVIAYLMQEHNISPAEALSHLRQARSICEPNDGFMKQLELYGEMHTPENVEQSPAYQRWVYQREIELSRACGQAPEADKIRFEDEHVADQNTGFELRCRKCRRALATSSQYLLKHTSPSTKDDESIDALVIAPTKDCAHYFLDPLSWMRPELEGRLECPKVLHQRWANTPGQGMQCSCGEWVVPRISLLKGRIDEAREVDRRYPTATWHSKWPCTNRWP... | 149 |
A0A251T6H2 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASCNNSSLIIGFLVLALVHFNRINALSSNYYDQTCPMVESTVTSSVKKAMLNDRTVPAALLRMHFHDCFIRGCDGSVLLNSTANNQAEKDGPPNISLHAFYVIDHAKKALEAVCPGTVSCADIVALAARDAVHLSGGPTWVVPKGRKDGRISRASETRQLAAPTSNISQLQQSFSQRGLSMEDLVALSGGHTLGFAHCSSFQNRIHNFATTQDVDPSMHKSFAASLRSVCPMHNKVRSAGANLDSTPTTFDNRYYKLLLEGKSIFTSDQALLTNPTTNTLVKKFANSREEFEKAFVESMIKMSSITGGQEVRLNCRFVN | 14 |
G5ECJ6 | 2.7.10.2 | ACT_SITE 403; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSNGNSYNHHHQFPMSIPISCSSHSIQSQSRMNTLNANRDLLSPGNDVIVTRTVSPSFYSHGMPARDNVFRKDDHVRILGNTTDPAWYRARNANQEEGLVHADCVVRINGQAYDNGIVRMRASGCDVAPGAASTTSSTSSHHSTAANHQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGML... | 98 |
E9HHQ5 | 2.7.10.1 | ACT_SITE 198; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MGESGSYACQWKVSFPGIQLGTGCFGRVVKAEAVGLKDSEEAVKTIAVKMVRSQANIEAMEALISELKILVYLGSHLNVVNLLGACTKQIHKGELFVIVEYCRFGNLQTFLINHRNSFVNLVDEFGNLKTQHEIESNNFTRKPTYGINPSIFLADFNLEEELDGNLDRSISTTNLISWSFQMARGMDYLVSKKVLHGDLAARNILLADDGVAKVADFGMAKKMYYEDCYEKRGQGLLPVNWMAIESLTDRIFSSQSDVWSYGIVLWELFSLGRVPYPGWTFPSIIKMNCRGYEYVSVNLGMDVGHILMKEILNGYRMDKP... | 97 |
W5M9H7 | 2.7.10.1 | ACT_SITE 1142; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | MRLDTPVVAFVTFICVLSNCGISDGEICKSMDIRNNITHLHAIENCTVIEGHLKILLMFKTKPEDFRGLRFPKLTMITDYLLLFRVYGLESLRDLFPNLTVVRGTNLFFNYALVLFEMLQLKEIGLHSLMNITRGAVRIEKNPDLCYLSTLDWSKILDSVEDNYIVSNKDDRECGDVCPGTAKGKTSCPQTIFNGHFSERCWTQDHCQRTCPSSCKHRACTKEGQCCHDECLGSCTAPNDPRKCVACRRYLHQGACVDNCPAGSYIFEGWRCVSFKFCQDLHNKCKQGTGCDEYVIHNGECIPECPSGYTTMNSTMLNCT... | 97 |
Q8EIY4 | 5.1.3.3 | ACT_SITE 175; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 306; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MVRFSVLDPWTDPRGGEIERVRIDNGIIALEVLSLGGIIRALWTPDKQGERANIVLGCDSAEDYLTQNAHLGAIVGRFANRIALGKLQHQGQTYQLDINQASNCLHGGREGFNRKNWHLGQLPDGVRLSLVSPDGDMGFPGNCTVQLDYRLAANNLYVEILASVDKPCPVSLTQHSYFNLDGTSNNHQHQIQIDATRYLTMNEVGIPMGIAEVKDSIFDLTQGVTLGEKLHDPTLASTRGYDHCYLMDNLDGSLRRFGCLSSPVSGRAMTVFTNQPGVQLYCANFLAGTLGRNQQRLNQYQGVCIEPQMLPDSPNQTQLG... | 211 |
A0A9J7KXY8 | 2.3.2.26 | ACT_SITE 798; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSSTQVGQQNLRPSTVACSQDATVSEETLAVGDGGKGLTEGRASSSSPRLPVNNAPSTTTTAGGSAGSTGLLPPISATTSKVMETDEQRKTHRPFAKISNFLSALRPRGGKQGEEKSVRKGSGRRRYVGNLPPIHPPQATPTCTSPLVTAPPTTPVRTSPTQPQQQQQQSPAKSQQPIIIRKTFQEFKDDATQAHSSGNFKTLQEFYSTSFDSFYQLVGTFQEESSTTRNPTEHPGVAVQLLDAAYSELMELPQDIQKVVLRGIVNSLLQKDIKGPRSFNDLRAYFIFLKNPQFSHVKTYVIFAHLIRHLAHLEDKEHQV... | 65 |
A0A1S4BD91 | 3.1.1.11 | ACT_SITE 402; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYNLRRKTSLLLTLFALSAIVSLTFFTLSNNPKSSSKTVLTTTPHIHVHKNIQIAHSHCQDTRYPKLCVSTLSLIPDLAQKSISQIISSTINVTVAEVKASARNCTDIREDLPQLEPYEKRALEDCVQLLDNTIIELRTTLSDLNPKKPPSQNYNDLQTLLSAAMTNQATCLDGLARSKKNLRRYVQHNLHTIAHHVSNCLSMLKKMKKSSFSSSKSQEIYPEYGAVKNGFPKWLKKRDRALLQAPINETKIDLVVAKDGSGNFSTINEALSAAPNASTTRFVIYIKAGAYFEYIEVVRKKPMIMFLGDGIGKTLIKGNR... | 125 |
A0A8J1KQC6 | 2.7.11.13 | ACT_SITE 549; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MVVFNGLLKIRICEATNLKPTAWSLRHAVGPRPQTFLLDTYIAVNVDDSRIGQTSTKQKSNNPTWHDDFSTDVSNGKRIELAVFHDAPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAAPKENEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGNHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLGVTPDKITAAGQR... | 100 |
G5EB16 | 2.1.1.37 | ACT_SITE 382; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MRQSAYIYLTFVSSCTVCELLLYTFLTRLSLPSCSRDMHNFYRPSVIVDDASDASSVTIDHDPDRLYFLREDSDTATREFIDLTEDETTHDGEYITDECFEVLREDWLASACASSPLSPELPEGQLLEEVCDADGIVYKPGNSVELHDGAFFRICSIRQALKGNIILTGRRLLKFKDHPDKYLPQWRNELIWVADETAEIPLWFVRRFVSVHFSNVCPIGQDCQKNNNPDGLFCRLKRVIQKETTSIEYLTFEEADAGFRAPSASLRHGWRGETAPFGSKEEAETPVIVLDDDNDFQDTILKQKAQRKYTFGDGFCGAGG... | 47 |
C5XG03 | 1.11.1.7 | ACT_SITE 100; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDSSRGAIRFLVHRRVLLLLLLVASSSLVGTSRGREAQPLPVAAAATVLGSRRAPERHGLALDFYAKTCPAVDQIVGNVTAARYRDFPAAGPAVLRLFHHDCFVEGCDASVLIAPTADAAARSPPRVERDVEENRNLPQEAFDTVELAKAAVESKCPGIVSCADVLALAARDYVQLAGGPYYAVKKGRKDSKVSLAGKVRGSLPRANSTVDELLRVFAGKGLGAADLVALSGAHTVGFAHCVHVLGRIYDFRGTRRPDPLMDGRLVKALRMSCPSSGGSARVVVPFDVSTPFQFDHAYYGNLQARLGLLASDQALFLDAR... | 14 |
P30656 | 3.4.25.1 | ACT_SITE 76; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:9087403" | MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG | 180 |
B5YKS0 | 1.8.1.4 | ACT_SITE 432; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MKAVVIGGGPAGYVAALSLKRLGAEVLLIEREELGGTCLNKGCIPTKTIIHSLGLLEKIKNQKIINEINYPNISVDLQTLMQKKDNVVDTQKKGLLMLLKHSGVKIIKSEAELINPQTVFLKETSEKIQADRIIIATGSKPAKLPMLSFDGKKILSSDDLWNLKKIPESITIIGAGAIGCEFAWIFHLLGSKVTLIELMPKILPMEEEDISKEVEKLFKKRKIQFYTGVRIQDLKIFDNSVQITLSNEKILTSEIVLVSVGRAFNTDCIKTSEIKLGNKKEIIVNERMQTNIENIFAAGDVIGNWLLAHVAYKEGEIAAK... | 36 |
A0A2R6W9E1 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAARGLTATLLIFALLASSASAQLSERFYNSTCPSGPAKVAEVVRTWITRDRTLAPALLRLHFHDCFVRGCDGSVLLDTVNGEKVAAGNINSLRGFEVIDDVKTKLEALCPGRMSCADILSLAARDAMVQMAGPILNWTVPLGRRDGVSSFASEANSALPPPFANFQQLVSLFSAKGFTTREMVVLSGSHTVGLSHCRNFQTRLYNFSATVATDPALEASFAAALKRQCKFGDTTTLVKMDQSKSVDTWDFSYYSNVLRGKVLFQSDDALKRTTEGSKIVQALNRAGSSFSAEFSAAMTKLSRVGVLTGTSGQIRRKCNL... | 14 |
A7ELS2 | 3.2.2.27 | ACT_SITE 170; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MIFDRTIPSVKVFLLLLFPNRSFTPSPIMSSKRKATTNPTNDTKKPKANGSITSFFGPPKTVSSTTKVTGTSTDTIAPAPATFKFNKEKWVATLTEEQKDLLKLEIETLHESWLAVLKDEIMGKEFLELKKFLKKELEGKDKIFPPMEDVYSWSRHTPFNTVKAVIIGQDPYHNFNQAHGLCFSVRAPTPAPPSLKNIFKALAKDYPDFKPPPNNGGLLTPWADRGILLLNTCLTVRAHQANSHANHGWEKFTQKVIDTVALKRTKGVVFLAWGSPAGKRVAKVDKNKHCVLMSVHPSPLSASRGFFECQHFKKTNEWLK... | 173 |
A0A0K9NQG1 | 2.1.1.37 | ACT_SITE 465; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MSASKKRNASVAHITPPSTRITRSRAANSLPPVVVLEIPEKEPLKVEYGVKEEEEESNGITVVESDTPVLDVSDEKPSIMKKMSSSSSDVSTKKALKNEVPKKGGRVPLAGSNGKHDEESQFVGEKLSDEVAKKKWPERYPTGEPGKPNYIGRIVEFFESTDGLFYFTSRWFFKAEDTVIGDIGQKSHSPKHHPKRVFLSEETDENLLDCIVSKLKIIKRDANIKDSIPKCDFFYDMSYSVQYSSFINLPKDEPHADSEESSTLSFECNTEISKEANSSQTHTTTVLDLYAGCGAMSTGLCHGAHLAGLDIETKWAVDIN... | 47 |
H9GNX5 | 5.3.1.8 | ACT_SITE 245; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MGTHPKGDAVIRDNRIPQKTLGQWIAVNPGCLGSKVKETFQGQLPFLFKVLSVNTALSIQAHPTKELAEKLHAQSPEHYPDANHKPEMAIALTPFEGMCGFRPGEEIVGFLQNVPEFRTLIGNVAAEQLERSVRDDPRGVAAALRVCFTRMMKSEKKVFVDQLNMLVKRISQEAAAGENISTSCGELLLRLHSQYPGDIGCFAIYFLNVVKLQPGECMFLGANEPHAYLYGDCIECMACSDNTVRAGLTPKFIDVLTLCEMLNYTPAPSSTKLLAPVQSRLDPYVYLYDPPVPDFSVMKIVIPASIKLYLISAVDSASIV... | 214 |
A0A2C9WGK9 | 1.11.1.7 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAAKSFITLLLFISLLSLASCLSSASETKFKANVTVSNGLAFGFYAFVCPQVEILVRNHLLQVFNRDVGQAAGILRLHAHDCFVQGCDGSILLDRSVERTELPNLSLRPESIQVIDTLRQIVHSQCGPVVSCSDLLTLAARDSVFFTSGFDYAVPLGRRDGVVFPRPGQTFEDLIAPNAKTTEVLTKYARKGLNLVDAVALSGAHSIGIAHCSSFSERIFPNRDPTMEISFFNSLRQVCPAPNANGIASLDIRSPFRFDNFYFIDLMNRQGVFTSDQDLFEDLRTRPTVITFAASQPLFFSSFAVAMTKMGSVEVLTGA... | 14 |
Q2G0Y7 | 1.1.1.205 | ACT_SITE 307; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964"; ACT_SITE 403; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964" | MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQI... | 3 |
A0A1U8NGA1 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEGNCFNQTVFLFTLLLAIAASSVRGHSTRVGFYSSTCPRAESIVKSTVKSHFKLDPTIAPGLLRMHFHDCFVRGCDASILIDGPNAEKTAPASQFLKGYKVIDDAKFQLECECPGVVSCADILALAARDSVVLTKGTSWAVPTGRRDGTVSVSKASDTDGNMPGFQDTVDVLKQKFAAKGLNTRDLVTLVGAHTIGTTACEVFSYRLYNFTSTGADPSINPAFVSHLQALCPQNRDGSRQIALDTGSADRFDTSFFAKLREGKGILESDQRLWTDVLIKTFVQRFLEVRGSLGLSFNVEFGKSMVKMSNIEVKTGTMGE... | 14 |
O66778 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSRIKRVHGREVLDSRGNPTVEVEVELESGALGRAIVPSGASTGEREALELRDGDPKRYLGKGVLKAVDNVNGVIAKALVGLEPYNQREIDQILIELDGTENKSKLGANAILGTSMAVARAAANELGIPLYEYLGGKFGYRLPVPLMNVINGGAHADNNLDIQEFMIVPVCGGAFREALRAGVETFHHLKKILKEKGYSTNVGDEGGFAPNLNSSEEALDILMQAIEKAGYKPGEDILLALDVASSEFYENGVYKFEGKERSAEEMIEFYEKLIQKYPIISIEDPMSENDWEGWKEITKRLGDKVQLVGDDLFTTNPKIL... | 200 |
A0A059BQ52 | 3.1.1.11 | ACT_SITE 181; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRNQGQFILYFLLALLSACTNFSEAGNGTQAPNLARLILVDPSGKGNFRKIQDAIDAVPSNNSELVFIRVEPGTYREKLVVPADKPFITLSGKKASSTIVTGDDSGDIFGSPTISVLASDFVGRYLTIQNTYGSGAKAVVLRVSGDRVAFSACRITSHQDTLLDDVGRHYYSNCYIEGDVDFIFGNAASLFQHRASPLENTGFIFLGCPWGPYSRVVFALSYMSSAVLPQGWDDRGDSTKQRTAYYGQYECYGPGADTSKREVSPLLTMDMVDQQSWFKNAPTIFN | 125 |
A0A061ELR2 | 3.1.1.11 | ACT_SITE 180; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MMPFLHCCYCLFIALFLSFQQGSAEGRCKKLLVDQSGHGNFSTIQSAINHVPPNNRNWFCIHIKAGTYREKVKIPYDKPFIILKGAGKRSTSVIWDDHQSLLQSPTFSSLADNIVVESMSFVNSYNSPNSKNPRVPAVAAMVSGDKSFFYKCGFLSLQDTLWDDQGRHYFKRCTIEGAVDFIFGSGQSIYEDSAIHFLGGELEPGLPGFITAQGRTNPNDANGFVFKNCNVYGSGTTFLGRPWRGYSRVLFYNCKFSDIIQPGGWEAWSFTGHENQLTFAEYGNHGPGSDTSKRVSWEKKLSVEAVEQLTSMTFIDSEGW... | 125 |
Q54W30 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTRLNVGDQCPLFSVKNKDGKEIKASDYIGKKPFVLFFFPNNIGYYCKSEVCEFRDAYEKFCEFGVEVIGASPNSVESHNRFAEKHKIPFNLVVDEGRKLAKTFGVDGFLITDRVTFIIDITGKIVFSHSALLKSTQHIEESLKLVETLSAN | 12 |
F6ZM46 | 2.7.11.1 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1" | IILLKTEMYCTIASMPTSDLISHNNLHGKLPSQLSHQKMYEVYGIIGVGGGGMVYSGIRIGDSQPVAIKRIMREKVKRWEKIYGRSVPQEIGLMIRVNGHHGVIKLLDWYECLDSFILVLERPKNSVDLFDYIREVGRMTEKEACMIFRQVVSAVHHIHARGVVHRDIKDENIVLNRDTGESKLIDFGCGTLLHENQYKDFSGTPEFYPPEWFNQHYYKGKTAAIWSMGVLLYDMLCGEIPFKSKQKIGQGKLEFKVSLSSEAKHLISWMLAVNPESRPNINEILQHPWVTLRR | 99 |
Q10038 | 3.1.3.48 | ACT_SITE 262; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MTVLDTVTISTCGLAALIREAPDTTLVVDCRGFTEYNESHVRHSMNAFFSKLIRRRLFENKLDDNCLIHQLMSCSSGCTKMDEKLDLVLYAEEDKPRGNKRRIASCNAPESTAKIMRVLRERLEDTDKFRSVMVLEGGFKQFAQQYPQLCESSEGMTRLPQSLSQPCLSQPTGDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDH... | 149 |
Q9RI12 | 2.7.11.1 | ACT_SITE 270; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKSVKIMGTMPPSISLAKAHERISQHWQNPVGELNIGGKRYRIIDNQVLRLNPHSGFSLFREGVGKIFSGKMFNFSIARNLTDTLHAAQKTTSQELRSDIPNALSNLFGAKPQTELPLGWKGEPLSGAPDLEGMRVAETDKFAEGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRKEEALLMDEVDGWRCSDTLRTLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGVVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTESFKAPELGVGNLGAS... | 99 |
A0A7M7SZG0 | 3.1.3.1 | ACT_SITE 106; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MEFTFSVFILLLASLSLVLGQDAAFWNNQARDSIQKALERELNIGEAKNIIFFLGDGMSVPTVTAARIRQGQLKGETGEENILAWETFPHVGLIKTYNTDAQVPDSAGTATAFFSGIKTKSGVVGIDDRVEYADCESGVGGEVDSVLVNAHNIGKATGVISTARITHATPAATYAHVAKRGWEVDTEMIEDGEDGKGCKDIALQLIEDNSFIKVILGGGRRMFYNNTELDPEDPSDRGNRTDGRNLIEEWQEGKANAYYVWNKEQFDAIDEDTTDYLFGLFEDSHMRYASESEEGNDPSLASMTEKAIKMLQKEEKGFFL... | 141 |
P15019 | 2.2.1.2 | ACT_SITE 144; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000305|PubMed:8109173" | MSEPAQKKQKVANNSLEQLKASGTVVVADTGDFGSIAKFQPQDSTTNPSLILAAAKQPTYAKLIDVAVEYGKKHGKTTEEQVENAVDRLLVEFGKEILKIVPGRVSTEVDARLSFDTQATIEKARHIIKLFEQEGVSKERVLIKIASTWEGIQAAKELEEKDGIHCNLTLLFSFVQAVACAEAQVTLISPFVGRILDWYKSSTGKDYKGEADPGVISVKKIYNYYKKYGYKTIVMGASFRSTDEIKNLAGVDYLTISPALLDKLMNSTEPFPRVLDPVSAKKEAGDKISYISDESKFRFDLNEDAMATEKLSEGIRKFSA... | 52 |
Q8AYG3 | 2.7.12.1 | ACT_SITE 775; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDEEESTERQMQIAMLCQKLAMMKQLFNEDDTDYINQAISSNSPDTCRTFLSNLEKKGNPQADPSLLSKLMDSYTRVFSSMPLGKYSQNESYAKMLVRFAELKAIQDVNDAQTSFDIARSHCKDFAFVHVAYAQFELLQGNMKKCTMILQKAFEMNAKPRHVLEAAVRNLKTGKRQLLSHEDKENLSVSALDHTQGSRRSDGTCELKPSNTFLHSDQKFSPQEENGPVWRTGSQHRRTAMAERVPMVPLSIPENETSDSDCAQKAEAPFTHSSGFSRQTSGSSVRSAFSLCSSKKGTPDGDSYSLNIKPPVISPDYLRED... | 107 |
A0A3B3H773 | 2.1.1.37 | ACT_SITE 1211; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MDEKPEGEPTEAHSVVAEDCLGNKENVIELSSEDEDCLLYVSGQQKAKQANGKYERSLKEEPAEEYQATQKSGGCSCNVANVLSLAVFQNEGAMRLKEILQAVSSAPFCLYLYVGVKLEKEEDTSFVLIGYFDQSLGKSVVRPLKTLQLSVDATDPQTSTPIHGVRPEDSDARLLIKALKDLNLPLSNLSMFYCSTPHPSVSHVFVSQLQAFNSKLISLCGIPGMAERACLAGLTASFGCVVDLVKEIHHYYSTCLSVNDTLKEVFAGVESVDPFHPGSERSSFIIRTVQKMVSCWQDLVEYFKSLANTEDTKGIKTLLM... | 47 |
Q6PA07 | 2.7.10.1 | ACT_SITE 901; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MGPIVLSAFILLVVVSTRAAILFTKEPYSQDALHGRSAILRCEVEEPVEVQFEWLQNGVPVRDTERRYQEGGSLTFTAVDRKQDGGTFQCVARNPNTGEEGRSNIAYFNIKWIESGGVTLQYPGSASDIQSSSRVILRCHIDGHPRPICLWFRDGTPLADDGQAISLSNRERTLTLHSAGPDDSGEYYCCAYNAAGSVCSNRNFTLSIIDESFPQAVVIPEDQVVNKNEDAMFHCLFSATPPPSQEWFFEDQVPLSNKSRITVFQNGSLLISSVRPRSSGVYSCVGTGYRGQKAVLKASLRLADIDKMRPLPPRVLTADM... | 97 |
Q756E0 | 3.2.2.27 | ACT_SITE 96; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MEAAEGGVAKACADERAKENFPEEQRRLLALELETIDASWQRILQPEFTKHYFLQLKRFVLEEQTRHTVFPPAEDIYQWTRLTPFSKVRVVIIGQDPYHNHNQAHGLAFSVRAPTPAPPSLRNIYKELQINYTDFVADNALGDLTRWATQGVLLLNTSLTVRAHCANSHSKKGWEPFTSRVVQLLVEDRRRTGQPLVFLLWGAHAAKLVDRVLGGRVPDNFLVLRSVHPSPLSASRGFFGNFHFRKINDWLMARGQRMIDWSVVPDTELKEVRDANKETGAASST | 173 |
A0A7I4EL45 | 2.2.1.1 | ACT_SITE 567; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MEATAAAMAMQKSPGAPRALNEGTQVRVPASRSVVSGAALPRCSQPAACLSKATQTSKWTGNWKPEKLAKLREANPFASFRRGLKMPHGARADSQSLQDEQVKTGQPGTQKQSVPSKIVDRKESSTPKEHMKAWKEEITSMLGGKEGNWEDSKWFQSQIDKRCVDNMRMLTVDAVNTAKAGHPGLPLGMAEVGYVLWRYVMKFNPKNPNWFNRDRFVLSAGHGCLLQYITLHLSGYDSVQIEDLKRLCQIGSRTPGHPENVTTDGIEVTTGPLGQGVANAVGLALAEKHLAARFNKHDGKIVDHRTFCIMGDGCAMEGIT... | 51 |
A0A804HZZ4 | 3.1.3.48 | ACT_SITE 23; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 25; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MGEMMDIEVPKEVAKPMTVYVWDMDETLILFKSLLDGTYAAAFDGLKDTRIGVEIGKRWENHILRVCDEHFFYEEIENYNEPFLHSLSEYDDGQDLSNYDFNNDGFCFPYDDSNKKKLAYRHRLIAQKYSQGLNKVLNQEMIKLWNDLYNSTDNYTDGWLSSGHALLEQTMGKTSFSASDLSSDMEPGSITTKCQNINVLVTSGALIPSLAKCLLYRLDDVISANNVYSSWEVGKLQCFSWIKERFGGPNVRFCAIGDGPEECEAAQAMRWPFIKIDLRPSSPHRFPGLDMKMVGSYIDVIYGAADAGAEEEKE | 149 |
Q4WMS5 | 2.3.2.26 | ACT_SITE 1784; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSPRITRSAARLAADSPSSAGSGPSSIPAAGSAPTRKRKAHARRDPPLDVPEETNPQSPTRRTKRQRLASPPHPASTVSTSRRGTRNRPAMSQQGPSASSPEETTKKQSSPPPSRRKSSRHRGKVSQDRPSATQSPLPRRQKKRSSRTNSDVMMKEAEEELDSHERTASRESSPSNDSNDGTTPSGIDDDDDADLFHNSLFGSRSPLGLQSTLRALSGMMSGMSSRLREILCNLRMKEDPSIQLIALQELSDLLLVSNEDNLSGQFSPDPYVKELVTLMQPDQVGEENPEIMLLACRCLANLMEALRGSVANVVYGGAVP... | 65 |
A0A8V1AHJ5 | 3.2.1.35 | ACT_SITE 144; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MRGGCAAVLALVPALPWLVPAVLAVLARQSPEKPSAAPLLTRRPFLVAWNAPTQDCKPRFQVALDFSVFDLQASPNEGFVDQNLTIFYKERLGLYPYYNKQGKPVNGGVPQKSSLAEHLARLQENIGKYIRSATSEGLAVIDWEEWRPIWMRNWKPKDVYQEVSRELVEQRQPFWSPEKVNKQAVFEFESAARHFMVTTLRYAKSFRPKQLWGYYLFPDCYNHDYSKNKESYTGQCPDVEKTRNDQLAWLWNESMALYPSIYLDPLLASTPNSRKFVRARVMEAMRISQQHHEGYSLPVFVYTRPTYSRKMDVLSQPDLI... | 166 |
P31765 | 5.1.3.3 | ACT_SITE 172; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10126"; ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000250" | MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVDNYPTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWNIQECGENFVCFSLHSVDGDQGFPGNVDVSVTYTLTGDNSVKIEYAGMCDKDTALNLTNHTYFNLENAEQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATKGYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN... | 211 |
Q9X248 | 1.1.1.100 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10001" | MRLEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGVFNVTQMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIGIDGGLVI | 2 |
H9GKJ9 | 3.2.1.23 | ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 266; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MFALFLLSLLCPALASSSSSSSVITSQRTFGIDYGHNCFLKDGQPFRYISGSIHYSRIPRYYWKDRLLKMKMAGLDAIQTYVPWNFHEPERGVYNFTGDRDLEYFLQLAQEVGLLVILRAGPYICAEWDMGGLPAWLLEKESIVLRSSDPDYLTAVGSWMGIFLPKMKPHLYQNGGPIIMVQVENEYGSYFACDFDYLRYLQNLFRQYLGDEVVLFTTDGASMFYLRCGALQGLYSTVDFGPGRNVTAAFSTQRHTEPKGPLVNSEFYTGWLDHWGHRHITVPASIVAKSLSEILASGANVNMYMFIGGTNFGYWNGANM... | 163 |
A8IL21 | 3.4.21.92 | ACT_SITE 149; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 174; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MAQLLLQNKFTAGAAARPARRSVAARSSAPELWTPTSEVKLAVSSRNPHPPVVCQGPPPPNPLVIERFQGVVSQLFQQRIVRLGGAVDDDMANLLVAQLLYLDSVDNKRDITMYVNSPGGSVTAGMAVFDTMRHIRPDVSTCCIGLAASMGAFILASGQAGKRYSLPNSRIMIHQPLGGAQGQATDIEIQANEILHHKLTLNGYLAQFTGQSMETITKDTDRDFFMSPQEAIEYGLVDAIISKPQMLQSREVALSS | 179 |
I1MS31 | 3.1.1.11 | ACT_SITE 441; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFQDFDLISERRRNEKRQKARKRIMIGVVSSVVLVAMIGAVLFVVVRNDNEAGNKKSNENKSHGHSQQSTTPGKDHVVAHSKMVKLVCSSADYKEKCEDPLNKAMEDDPKLTQPKDLLKAYVKFAEDEVSKAFNKTISMKFENEQEKGAFEDCKKLFEDAKDDIATSISELEKIEMKNLSQRTPDFNSWLSAVISFQQNCVDGFPEGNTKTELQTLFNDSKEFVSNSLAILSQVASALSTIQTLARGSRSLLSENSNSPVASLDKADGLPSWMNHEDRRVLKAMDNKPAPNVTVAKDGSGDFKTISECLNAVPQNFEGR... | 125 |
P23292 | 2.7.11.1 | ACT_SITE 195; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSQVQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLHVSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRY... | 99 |
A0A3B6HU20 | 3.4.19.12 | ACT_SITE 38; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 148; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 163; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MESGARSEVRPDEEGPAPAGSSSGGSKVYHERQRMQFCLLHALNNLMQEKESFTRAELDGIAENLVLTDPNKEKWTPLSLIWKPHHNALTGNYDVNVLIAAVESRKKKVVWHDHRKGASSIDLDAEALVGLMINVPVRRLRGLWTGRHWVAIRSIDGIWFNLDSDLPSAKQFQCKEKLIAFLDSVLSQGGELMIVLQDE | 175 |
Q8CWR2 | 5.4.99.25 | ACT_SITE 38; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGVLPIAVGKATRMVEFMQDEGKIYEGEIILGYSTTTEDASGEVVAETPVLSSLDEKLVDEAIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVIIYQFERTSPISYDGQLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALALEEIAEKVEAGQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLAILEKRGNLYKPRKVFS | 218 |
Q75EG2 | 3.4.25.1 | ACT_SITE 30; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MAGLSFDNYQRNQHLASTSHKQPRATSTGTTIVGVKFEGGVVIAADTRSTQGPIVANKNCEKLHRIAPRIWCAGAGTAADTEAVTWLIGSNLELHSLYTGREPRVVSALQKLKQHLFKYQGHIGAYLIVAGVDPTGAHLFSVHAHGSTDVGQYQSLGSGSLAAMAVLEAQWREGMGRADAMALAAAAIEAGIWNDLGSGSNVDLCVMEVGKDAELFRNYITPNTREAKQNSYKFARGTTAVLRESTLQIYDEEIVDTAA | 180 |
Q47910 | 7.2.2.10 | ACT_SITE 78; /note="Phosphothreonine intermediate"; /evidence="ECO:0000250|UniProtKB:A1YYW7" | MNFKSTVITAMCCFFSFAVLASEKLEKPKLVVGLVVDQMRWDYLYRYYDRYSENGFKRLLNEGFSSENTLIDYVPTYTAIGHSTIYTGSVPAINGIAGNDFIIQATGQNMYCTQDDSVQAVGGEGKVGQQSPKNLLVSTITDQLKLATNFQSKVIGIAIKDRGGILPAGHFANAAYWLDGKTGDWITSTYYMKDLPKWVKGFNKEKVVDQYYKQGWKTLYPIDTYVLSTADDNLYEETFKGEKTPTFPRDLVKLKKENGYELIKSTPQGNTLTLDFAKRAIENEQLGNNPLQVTDFLAVSLSSTDYIGHQFAINSIEIED... | 258 |
Q12706 | 2.7.11.1 | ACT_SITE 215; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPVFMFDEHDNLNENYNSHLSSDDEIAEEGYDFEELEASASTITSSSDLKDGKNAKDEKGTVEFKVAAHGDFISSKGDNYVPSGKMRPADFQPLTVLGRGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRLYYAFQDHDRLYLILQYAPGGELFSHLAEQRMLPEDVVAFYTAELTLALIHLHKLGIVYRDLKPENCLLDAEGHILLTDFGLSKVAENGADCRSFVGTEEYCAPEILLEQPYDHAVDWWSMGILIFDLLTGSPPFTANNHKRIMEKITRAKPNIPFYVTSDARDII... | 99 |
Q54BC9 | 2.7.12.1 | ACT_SITE 731; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTSLHKQIIESHNNDITKLKSSMSTRAAARRSVCLSSMSYTLGADDVTPITSNTTPSNNNNNNNTTTTITTTTTTPTISPLKQSTTGSIIPKSILVTKSGSKEEPIVSSSKSSSNSSSINNNFNNLYSASTFSSSTKKVHERPSINPGFRKPREALLSGNSDSGIIKKPSSSSTSSSSSSSSTTSNIKAPIQISHSSNSGSSSSGGNNNNSDDNSGSSTIKHTAASLSKMKLSPSHTISDSPRSSTMKSRSVSISNGSLFSPTNTSVNNSNNNTSSNIKTPTKSSISENLDQNTPPPPSSSSTTKTPTATTTTTTTTTSS... | 107 |
W5NDC4 | 3.4.19.9 | ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 245; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | TFAMQKYLISTSFLGYVCDALPAAYLKDPVNDRPIIGILTQEVVDDEMKPYGKTYIPASYVKYLESAGSRVMPVRLNLTFADYEKIFNSINGMLFIGGAVDLETSDFAKAAIIFYQLALKAYDSGDYFPMWGTCLGHQLLTVLVAKENLLTKTPAENLALPLNLTTAAKSSRVFENFPHETLKALTQEPLTGNFHHYGVTFETFKGNEKLEQFFSILSTNIAENGVKFVSTMEGKKYPFYGVQWHPEVNRFEWDPKVQYPHSRNAVRVSSLLAEFFVNEARKSSHHFSNPEDEEAALMYNYVPMFTSAFTSYNQVYFF | 176 |
A0A2R6WVK6 | 3.4.21.92 | ACT_SITE 191; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 216; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MAHACTAMPVAAVAAPVAGSSLRKSPASLRHPSSLPQSLRLPALVSSSRSRRGIIAPQASIRSERLWTPSSDVVRDVWSIRNDLDVPTSMYAGPYANQGQGPPPMVQERFQSVITQLFQHRIIRCGGAVDDDMANLIVAQLLYLDAADPNRDIIMYVNSPGGSVTAGMAIFDTMRHIRPDVSTVCVGLAASMGAFLLSGGTKGKRYSLPNSRIMIHQPLGGAQGQQTDIEIQANEILHHKANLNGYLAYHTGQPLEKIVTDTDRDFFMSAKEAKEYGLIDSVISNPLKALQPLPAPVPA | 179 |
Q6NKW9 | 3.2.1.39 | ACT_SITE 119; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 265; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MSNLLALVVGFVIVIGHLGILVNGLGVNWGTMATHKLPPKTVVQMLKDNNINKVKLFDADETTMGALAGSGLEVMVAIPNDQLKVMTSYDRAKDWVRKNVTRYNFDGGVNITFVAVGNEPFLKSYNGSFINLTFPALANIQNALNEAGLGNSVKATVPLNADVYDSPASNPVPSAGRFRPDIIGQMTQIVDFLGKNNAPITINIYPFLSLYGNDDFPLNYAFFDGAEPINDNGIDYTNVFDANFDTLVSSLKAVGHGDMPIIVGEVGWPTEGDKHANAGSAYRFYNGLLPRLGTNKGTPLRPTYIEVYLFGLLDEDAKSI... | 167 |
Q9L2L6 | 3.2.1.21 | ACT_SITE 162; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 358; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MATDDAMPAKPMPRFPDGFLWGVSTSAHQIEGAAGLRGPSVWDAFTAEPGRVRDGSTAAVACDHYHRYREDVALLAGLGVDAYRFSVSWPRVDSPGGLDFYDRLVDELCAAGVRPVPTLFHWDLPAGLDWLERDTAARFAEYVSLVAERLGDRVGKWITLNEPAEHTLLGHALGVHAPGRELLFDALPVAHHQLLAHGLAVRALRAAGATDVGIANSHGPTWPASDDPADREAADFYDLLLNRMFADPLLTGRYPEGVGALMPGSAERVEADLEVIAEPLDWYGVNYYAPTRVGAPQGAEIEFGGVTLPAELPFSVRRIE... | 161 |
A2BIL9 | 4.6.1.16 | ACT_SITE 246; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 254; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 285; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MDGDPAVMKVPRSSSVEVKEDMDTKSEKQATGDTLIDISFCGSTPMLWKVPDMKKCRSEGVIGALVGSLARQPRQNVRLGRPLELRPEEALLLLEEEKSTAAVRLDTQQDFEDREAHSEAVRLYEASLESSYQEQCVLALEDKKKTLNRVMNEKENGTEGSGSAVRERLEALDQSFRFPWSAMAVQLCTARSGFSHCPEERSFHSTDCPMPRDEHLNTRFSVYRDLRNKGYYLTSAGKFGGDFLVYPGDPLRFHAHYIALCVSLDEEMPVCDILAIARLGSNVKKTVLLCSPQDGDVVYSSLQWSSMV | 207 |
Q8ZNR3 | 2.3.2.26 | ACT_SITE 753; /note="Glycyl thioester intermediate"; /evidence="ECO:0000305" | MKISSGAINFSTIPNQVKKLITSIREHTKNGLTSKITSVKNTHTSLNEKFKTGKDSPIEFALPQKIKDFFQPKDKNTLNKTLITVKNIKDTNNAGKKNISAEDVSKMNAAFMRKHIANQTCDYNYRMTGAAPLPGGVSVSANNRPTVSEGRTPPVSPSLSLQATSSPSSPADWAKKLTDAVLRQKAGETLTAADRDFSNADFRNITFSKILPPSFMERDGDIIKGFNFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSDMNEVFLQYSITTQQQPSFIDTTLKNTLIRHKANLSGVILNEPDNSSPPSVSGG... | 65 |
M0ZJ70 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKFGDLDNFLVLCILLGIVGSSYGQLQLNFYAKSCPQAEKIIQDYVQKQIPSAPSLAAALLRLHFHDCFVRGCDGSVLLNFTSSTKNQTEKVAVPNQTLRGFSFIDGVKKALEAECPGVVSCADIVALVARDSVVVTGGPYWKVPTGRRDGRISNASEALANIPPPTSSVSSLQTSFASKGLDLKDLVLLSGAHTIGVSHCPSFSSRLYNFTGVWGKKDPSLDTEYASNLKMKKCKSINDNTTIVEMDPGSSSKFDLSYFQLVLKRKGLFQSDAALTTSATTKSFINELVQGSLKQFYVEFGLAMEKMGKIEVKTGSAA... | 14 |
Q6C4K5 | 4.1.2.13 | ACT_SITE 110; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001359-1" | MPVTDVLKRKSGVIVGDDVRALFEYAREHKFALPAVNVTSSSTVVAVLESARANKSPVIIQMSQGGAAYFAGKGVDNKDQTASIQGAIAAAQFIRTIAPVYGIPVIVHTDHCARKLLPWLDGMLDADEEYFKTHGEPLFSSHMVDLSEEEHPENIATTAEYFKRAAKMNQWLEMEIGVTGGEEDGVDNTGVDNSKLYTQPEDIYAVYSALAPISPNFSIAAAFGNVHGVYKVGNVKLHPELLEKHQAYSAEKVGSPEKHGNGKPLFLVFHGGSGSSDSDYKIAIDNGVVKVNLDTDLQYAYLVGIRDYILSKKDYLMQQV... | 197 |
Q47WR3 | 2.2.1.2 | ACT_SITE 135; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MTNSSSQLAQLKQMTTVVADTGDIEAIAKFQPQDATTNPSLLLKAASLPNYQGLVKDSVAWAKTQSDNAEQQVIDAADKISVLIGLEILKIVPGRISTEVDARLSFDTSASITKAHKLIAMYNEAGISNDRILIKLASTWEGIKAAEQLEQEGINCNLTLLFSFAQARACAEAGAYLISPFVGRILDWYKKDTGRNDYASNEDPGVVSVTSIFNYYKLQGFNTVVMGASFRNIGEILELAGCDRLTISPQLMEELANSTDTVIQKLTACEATAEKEAALSQAEFRWQMNEDPMATEKLAEGIRNFTIDQVKLEKQLTDLL | 52 |
U5D4Z6 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRLNSYGVMGVLVLALLGTCHGELKMGFYDKTCPNAEKIVSDFMKEHIPKVPILAASFLRMHFHDCFVRGCDGSVLLNSTSNSTSEKEANPNLTLRGFDQIDRVKVLVEAECPGVVSCADILALSARDSVGVLGGPFWKVPTGRRDGSVSLRAEANAQIPAPTNNFTTLKESFANKSLSVKDLVLLSGGHTIGIARCTSFSRRLYNFTGVGDQDPSMDSNYVANLKQRKCRTQTDNTTIVEMDPGSFRTFDLSYYRLVLKRRGLFTSDAALITDSTSKSLVEDLTNGTPEDFFKEFAKSMVKMGEIDVKTGSSGEIRKH... | 14 |
A0A251VC49 | 3.2.1.14 | ACT_SITE 134; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MKTKLSTLLFLGVFLSGILLPAPVASQKCNCARGLCCSQYGYCGTGNAYCGKGCRGGPCSQPAPQNNADVSRIVTQAFFNGIFSTAAGNCPGRRFYTQDAFLRVIRDYQQFGRTGSFDDSKREIAAFFAHVTHETGHLCYIEEIDGHSKNYCDKSNTQYPCNPRKSYHGRGPIQLSWNYNYGSAGESLGFDGLNNPEIVATDPVVSFKTALWFWMENVHWDFASGKGFGATIRAINGGECDGGNRAAMNSRVKYYTDYCRQFGVPTGNNLMC | 158 |
A0A2R6XNK4 | 3.1.1.11 | ACT_SITE 269; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAGSSGTRRLCIAALLLVCAVVAVSALSAEEEYDEWLHYISKTSDPVSDETVNSLNAKILNKQSITSDISSSLSGYDAWLAKQKVLAASKPDVQPAEQRRHGGNSKTEEVIYVAKDGSGDFYTIAGALASIPVYNSARKTLFIKEGVYEEKIVIPSSQKYITFIGEGADKTVITGHATAGDEYGDALLKTYRSATVGVNSDHFIAKNIRFENTSPPPEPGAIGKQAVAFRISGDKAAFYNVAFLGAQDTLYAHQGRHYFQNAYIQGSIDFVFGNGKSYFKDSHLHSIADSFGSLTAQKRNESDMNTGFSFVNCKIDGTGI... | 125 |
A7F894 | 1.1.1.37 | ACT_SITE 201; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MFAARRALTGAVQSRAFSASARDLSKVTVLGAAGGIGQPLSLLLKLNPRVTDLALYDIRGGPGVAADISHINTKSKVTGYEPTPSGLAAALKDAEIVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAESAPNANILVISNPVNSTVPIVAEIFKAKGVYNPKRLFGVTTLDVVRASRFVSEIKKTDPADENIVVVGGHSGVTIVPLFSQSSHPDLVGNENLLKRVQFGGDEVVQAKDGAGSATLSMAMAGARMAESLLKASQGQAGIVEPTFVDSPLYKDQGVDFFASKVELGPDGVQKIHEVGKVDAVEEKLLEAC... | 5 |
A0A8W4FN02 | 2.3.2.26 | ACT_SITE 1549; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGAAGSQHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFRV... | 65 |
O67605 | 2.7.1.11 | ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MRIGILTAGGDAPGMNAVIRAVVRSAEREGHEVIGIKRGYKGLIEGDFIKLTSRDVGGILDRGGTILLSSRDPRYKKLEYREKAYKNLNEQGIEALIILGGEGTLAGAKLTAEETGIPVIGVPCTIDNDVGGTEYCIGYDTALRNAVDAIDKIRDTASSHERIFIVEVMGRNRGFIAVEAGLATGAELILIPEERFPREQIPEEIEKAKKLGKLHFIIVLAEGYCRAKELEDFLLEKIGDKYGEIRSTVLGHIQRGGIPTHFDRIMGTKFGVVAYESLIAGERSGFVAYEKGKFYIEDFEKAQEYKPIDREAYKLNTRLA... | 84 |
Q12043 | 3.1.1.3 | ACT_SITE 216; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 375; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MSNTLPVTEFLLSKYYELSNTPATDSSSLFKWLYHKTLSRKQLLISDLSSQKKHAISYDQWNDIASRLDDLTGLSEWKTIDESSLYNYKLLQDLTIRMRHLRTTHDYHRLLYLIRTKWVRNLGNMNNVNLYRHSHTGTKQIIHDYLEESQAVLTALIHQSNMNDHYLLGILQQTRRNIGRTALVLSGGSTFGLFHIGVLAALFESDLMPKVISGSSAGAIVASIFCVHTTQEIPSLLTNVLNMEFNIFNDDNSKSPNENLLIKISRFCQNGTWFNNQPLINTMLSFLGNLTFREAYNKTGKILNITVSPASIYEQPKLLN... | 128 |
P82600 | 1.11.1.7 | ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00298" | MAKKVLLLSLYSAVLSTWFGFGYVQCKLPTSRSEIPNFDYTVAQQPDQSDACEQNEVCMVSVECILDAKKKAILKPCSTVPSVDGVCCPSSEYNGTSSRVQQNSEEHAADHLVLQAIHEGRREYDEKLRFEDEHRAVMTAKEKPEAMFHRMFLPGGLKTHGKEVVDAEEQANVYGHVFASRKYAELTNMTLKQRQGDRFARIPRAIRKRCLPPVPCNPHSRYRTIDGSCNNPLPDRTSWGMEGYPFDRVLEPAYEDGVWAPRIHSVTGNLLPSARVISVALFPDEYRPDPRLNILFMQMGQFISHDFTLSRGFTTKHGQA... | 14 |
P9WFZ5 | 3.1.3.12 | ACT_SITE 147; /note="Nucleophile"; /evidence="ECO:0000250" | MRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFGSGLDVPIVAAGRLAVRPGRCVVVSAHSAGVTAARESGFALIIGVDRTGCRDALRRDGADTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVARQPAVFFDFDGTLSDIVEDPDAAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFELTAPDGTHHQNDAAAAAIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAVRTAEQRHALRVTTGREVIELRPDVDWDKGKTLLWVLDHLPHSGS... | 143 |
C0LGF5 | 2.7.11.1 | ACT_SITE 900; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MERERSNFFFLFLFCSWVSMAQPTLSLSSDGQALLSLKRPSPSLFSSWDPQDQTPCSWYGITCSADNRVISVSIPDTFLNLSSIPDLSSLSSLQFLNLSSTNLSGPIPPSFGKLTHLRLLDLSSNSLSGPIPSELGRLSTLQFLILNANKLSGSIPSQISNLFALQVLCLQDNLLNGSIPSSFGSLVSLQQFRLGGNTNLGGPIPAQLGFLKNLTTLGFAASGLSGSIPSTFGNLVNLQTLALYDTEISGTIPPQLGLCSELRNLYLHMNKLTGSIPKELGKLQKITSLLLWGNSLSGVIPPEISNCSSLVVFDVSANDL... | 99 |
A0A2K1K626 | 3.1.1.11 | ACT_SITE 374; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLGNLRISRELQEDANINDGSIHQSAPQPSSVTAACAATQHPDSCSDTLKNSTHSDAKIYTSTTVAAASSGIEETRLSVKNSETPENAPAVEVCEDTLNSALAVLEAVLEELKTVDAASFDEIKTRVTAAMEFHTTCMDALEEVGGPISTSVQLSTERAKQLFSVALSFVNAYASFGNDFLAWAKSSGLDLTQFNLHRRRLFPLTALHGPTAPPAPNQACKRHYKVTVAWNGSGDFKTITEAVNKAPTKSETLYVMYIKAGTYNEQVILKTSHFNIMFLGDGATQTIITGRLIVASGVTAYKSATLIVEGQGILAKGIQV... | 125 |
A0A3B3IHV6 | 3.5.1.98 | ACT_SITE 794; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MTSHSQQEGILGKEPPLEVLKTSALNHIPTVDISSALPLRLPPAAIPMDLRVDHQASPPGQQSPGPLGGTGGQQGAVAASMREQQLQQELLTLKQKQQIQRQILIAEFQRQHEQLSRQHEAQLQEHIKQQQELLALKHQQELLEHQRKMENHRLEQELEKQQREQKLQLLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRSLNQAGVPNDAPYWYRKTQHSSLDQSSPPQTGVSTYNHPVLGVYNPRDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRRDSPIATAKKRSLDMADSACSSAPGSGPSSPNNS... | 184 |
A0A1U8JIS0 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGAFWLVFIVNIVMVSLVQGQGSGLQNGFYSSSCPKAGAVVRSTVESHFNKDPTIAAALLRLHFHDCFVQGCDGSVLISGSSAERSALPNLGLRGFEVIDDAKALLESLCPGVVSCADILAVAARDAVDLSDGPSWAVPTGRRDGRVSSSSQTSSLPSPLESIAVQRQKFAAKGLNDHDLVTLVGAHSIGQTDCLFFRYRLYNFTTTGSADPTINQSFLTQLQSLCPRNGDGSKKVGLDIGSETKFDVSFFKNVRDGKGVLESDQRLWGDDGTRRVVENYAGNVRGLLGLRFDYEFRKAMIKMSSIEVKTGSDGEIRKTC... | 14 |
P23280 | 4.2.1.1 | ACT_SITE 85; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P00918" | MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN | 199 |
Q2FY51 | 1.8.1.4 | ACT_SITE 452; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MSEKQYDLVVLGGGTAGYVAAIRASQLGKKVAIVERQLLGGTCLHKGCIPTKSLLKSAEVFQTVKQAAMFGVDVKDANVNFENMLARKEDIINQMYQGVKHLMQHNHIDIYNGTGRILGTSIFSPQSGTISVEYEDGESDLLPNQFVLIATGSSPAELPFLSFDHDKILSSDDILSLKTLPSSIGIIGGGVIGMEFASLMIDLGVDVTVIEAGERILPTESKQASQLLKKSLSARGVKFYEGIKLSENDINVNEDGVTFEISSDIIKVDKVLLSIGRKPNTSDIGLNNTKIKLSTSGHILTNEFQQTEDKHIYAAGDCIG... | 36 |
A0A1L8FDT7 | 3.1.1.3 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 281; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MVGLWGLIFFLLRCAQGAEVCYNILGCFTDEAPWGGTAERPLGLLPMSPETINTHFFLFTKENPDNVQVISALDHSSLSTSSFNPNRKTYFIIHGFLRSAEDHWLMDMCKTLLKIEDVNCFCVDWRGGSRTLYTQAANNIRVVGSQLAYFINFLYSQYNYSPSKIHIIGHSLGSHTAGEVGKRVPGIGRLTGLDPAGPLFQNTPPEVRLDPTDADFVDVIHTDASPLIPKLGLGMSQLVGHLDFFPNGGETMPGCERNVINQLLSINQLWEETDEFLACSHLRSYKYYTDSILTPDAFVAFPSETYEAFKKGSGFPCPST... | 128 |
Q9EWF7 | 1.8.4.11 | ACT_SITE 14; /evidence="ECO:0000255|HAMAP-Rule:MF_01401" | MAAQTQRAVLAGGCFWGMEELIRRLPGVTATRVGYTGGDVPNATYRNHGTHAEAIEILFDPEATDYRALLEFFFQIHDPSTKNRQGNDIGLSYRSAIYYVDDEQKRIAEDTIADVDASGLWPGKVVTEVEPVGPFWEAEPEHQDYLQRYPDGYTCHFPRPGWRLPARSGSEG | 39 |
A7E716 | 3.4.21.89 | ACT_SITE 49; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367"; ACT_SITE 90; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367"; ACT_SITE 115; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367" | MLSFLQNPRQAAAQVLNFALILSTAFMMWKGLSVASDSPSPIVVVLSGSMEPAFQRGDLLFLWNRNLLEETKVGEIVVYNVKGKDIPIVHRLVRKFGAGPKAKLLTKGDNNVADDTELYARGQDYIEREDIIGSVVGYIPFVGYVTILLSEHPWLKTVMLGMMGLVVVLQRE | 178 |
A0A8I7BBR6 | 3.5.1.98 | ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MDMGTNSLPSPSCADGRKRRVCYYYDADISNVDYGEGHAMVPRRVAMTHALIASYGLLNDMTRLRIRPARPEELLAFHDQKYVHLLGDLTPAGYTNDVALRRAAKEHGLGPVRRPDGSYPNDNPVIDGLLGYCQGYAGGSLAAARALCGGDHDVAINWSGGMHHACRGQASGFCYVNDIVLAIKQLLARFRRVLYVDIDAHHGDGVEEAFADSDQVMTLSFHQYAGGFFPGTGSVDDVGKGAGLYHALNVPLKAGMDDQGYHELFKPIVGRAMQVFQPEAVVLQCGADSLSGDRLAGLDLSVGGHAECVRYLRGFDAPLL... | 184 |
I1IHH5 | 3.1.1.11 | ACT_SITE 267; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEGDKSKTPSFAIAFLVLLLLASSFPPATSQHQQASFVIGGNGGGGGNKPSSGSAGGGGGAGSFDDFITKNVQHYAVTEQLYASKAKANGGKLLDADLSAAEAAKVRYVVSPNGKGKFRTISEAIKAIPEKNKQRVILDIQPGTYKEKFLIPTTKPFVTFLGNPRNPPVITWDDTAGTRGKDGAPIGTLGSATVAIESDYFMASGIVFKNHAPLAPPGAKGGQAVALRVFGTKAAFYNCTFDGGQDTLYDNKGLHYFKNCVVKGSVDFIFGFGRSLYVDCTMVSVTSQVAVLTAQQRSRSIAEATESGFSFVRCKIMGMG... | 125 |
P28628 | 3.4.21.89 | ACT_SITE 43; ACT_SITE 83 | MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSMYPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYINGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGLFTKKQIAGTSKFVFYPFNEMRKTN | 178 |
A0A2G3A1G0 | 5.1.3.3 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 331; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKKSFFYFFAFVILILCKNNNSCTAAEEIKLYELKKGDFSIKITNYGATVLSVIVPDKNGKLDDVVLGYNSNDDYKNDTTYFGGLIGRVANRIGGAKFELNGVEYKLPANDHGNTLHGGSRGFCDVMWTVEDFQEDSHITLTYNSFDARQILIIKCCETGFPGDLSVKVTYMFIGTNKLAINMQAKPLNKATPVNLASHTYWNLGGDTSGDILSHTIQIFGSQITPVNDQLIPTGKITPVKGTGYDFLQPRTIGSELSEIPGGYDINYVLDNTKGKHFHRAATVQESKSGRKMELWTNKPGVQFYTSNMLDNVKGRGGF... | 211 |
A0A9J7HUC9 | 3.2.1.52 | ACT_SITE 339; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MKPCLVLLVALSLQAAVAEWSYQTSWYEKARQDKVARGTVWPQPRSIDTTSVRYYLDPRNFRLEADSSSAAVSDPECKEVVDHALSRYGELLFWIPEEDRAGVDGDETLDKLVLTVTSGCTRYPSLESDESYSILVSSDGATLRAQTAWGALRGLETFSQLIYGENGKHVVNGTSISDSPRFPHRGIMIDTARHYLPLPFILHHLDAMAYNKMNVLHWHIVDDQAFPFQSTTFPDLSGKGAYTRKHVYTPDDVSQVIEFARLRGIRVIPEFDSPGHMMSWGQGHPEILTRCYPTSFQPDIYYLGPANPARETTYTFMRKL... | 170 |
Q8ZVL9 | 5.6.2.2 | ACT_SITE 96; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_00132" | MSTRSEFLKRLESWGTQLAKAILELEEPIMEIPARTLSNTIWDEKARMLKLGPEKLHRRFLDVKEARKFMQTVLMLRLIVEAIREDVYPTIRDLYYNGKHTIVFKDPLGRTHRENTWDEQSESNAVIEDIEVATNVLREEMGVSADVKGKIVGPIVVRSQGYELDASKFGETALSLPVNVDALEIVKVEASYVLVVEKDAIFQRLVREKFWSQEGAILVTAKGMPDRATRRFIRRLNEEYKLPVYVLTDGDPYGWYIYSVYKSGSIKLSYESERLATPDAKFLGLTATDIDTYKISDNYVIAANDRDIKRAQELLRYPWF... | 222 |
Q4QRJ9 | 3.1.3.1 | ACT_SITE 115; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MAKTQALLLIGIFASAGFDGCFSVVPEEEKNPNFWYVKAKDSLHASLSMTFNTHRAKNLILFLGDGMGISTVTAARVLKGQMNKKTGEESVLAMDTFPYLALSKTYNVDQQMPDSAATATAYLCGVKANYGTLGLSAAAQREVCSSVKGNEVKSILHQAKMAGKSVGIVSTARVQHASPAASYSHTPERGWYSDKELTSEAVAGGCQDIAVQLITNTDINVILGGGRQYMFPRETTDPEYSTVTGSRKDKRNLVDEWLKNRKNAQYVWNKQQFDAVNEDKTDYLMGLFEPKDTRYELERDPKMDPSLTEMVEKAIKILRK... | 141 |
A0A3Q1MKB4 | 2.7.10.1 | ACT_SITE 858; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MKLETGLWVWVSLLLAAGTVQPSSSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYTDTIHWQDIVRNPWPFNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGI... | 97 |
W5NA14 | 2.7.10.1 | ACT_SITE 1040; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | RIKASVEGLLSQYTISFPLFSASTLKYMPDPPKLSISDKVYKINATDTLELTCRGQHHLEWTWPRNESGTEQGLSVVDCSGSGLFCKTLVLVKATANDTGEYRCSYRSLPVNQGKTSASIYVFVQDYRSPFVSSSPNFEFVFIREASPVVIPCLGSIEDLSVTLYTNYPRKEFFPDGKTIYWDSRQGFTIPSRFISSAGVAFCQTIIQNETFQSSLYIFAVVGYRIHELSLTPKYQVKLAVGEKLLLNCTATTELNVGIDFQWKYPAWKKSVGARQKENRSEIKPYKKKLRDCLELSSTLIIEHVTLNDTGEYICTASSG... | 97 |
A0A1B6PCH9 | 1.1.1.100 | ACT_SITE 239; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAASTASSWSAAGGLSATSCVSPPPQRRHGSSLKPPQRSGQPAATTLSASGNQPNLSYLDCRTRTRRRGDRIRAADAVTMDGWAARLEAPVAVVTGASRGIGRAIAVALGKAGCKVIVNYAKSGMEAEEVCREIEESGGTAISFAADVSCEADVESMMRAAIDAWGALDVLVNNAGITRDALLMRMKKTQWQEVVDVNLTGVYFCAQAAATVMMKRKKGRIINIASVSGIIGNVGQANYCAAKAGVIGLTKAMAREYGGRNINVNAVAPGWVASDMTNKLGDDVERKALETIPLGRFGRPEEVAGLVGFLAVHPAASYIT... | 2 |
A0A9R1W6G1 | 3.1.1.11 | ACT_SITE 406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNKTRQMDDGSRKFTIIGIAVILLIMAVSGAVGVVKIYNKANEREEHKVTTSNKAVESLCQHTDYRKSCRKSLANANDTDEPQELMKIAFSSAINEIEHAINKSSTLQAVAKDPRATQALEMCKSLLTTSIDDLKRSLKKLDNFDISKMEEYLADLKVWLSGSLTYQETCLEGFTNTTGDVGEKMKKILKLGGKLTSNSLAMVNSVDEYLGEVQLTSMGSRRLLDKGLNDDHHAYAWWTKGYKRLLIDVDWKALKPNVIVAQDGSGTFKTIMEAIKKVPNNNTQPFIIRIKQGVYKEYVDIPRLVNNVIFIGEGHNRTRI... | 125 |
Q8H2J9 | 1.1.1.8 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000250" | MAAAAAATFLPHTPTPRRRLAVAVHSPTRRRLSLVFSGPPDGALSVAAAEEKADAGEEAAAAVSAPRGGGGGGGKERRRVVRKAWEKLVRWSRSWRRRNRSDVVETTRKVVVLGGGSFGTAMAAQVAAKKADLEVSMLLRDDLVCRSINHSHINCKYLRDHRLPENITATTSASDALAGADFCFHAVPVQFSSSFLEGISTHVDPKLPFISLSKGLELNTLRTMSQIIPQALGNPRQPFIVLSGPSFAIELMNKLPTAMVVASKDKKLAAAVQQLLASPNLRISTSNDVTGVEIAGALKNVLAIAAGIVEGMHLGNNCMA... | 7 |
P50382 | 4.2.1.20 | ACT_SITE 37; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 48; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVKGLDIWPLIEDIRKDVGVPIIALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDLDKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYYGVRPTTGVPIPVSVKQLINRVRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAILDEYK | 202 |
B9S3R8 | 3.2.1.21 | ACT_SITE 415; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055" | MIVQLCLFLCLFNLAYFWDQVGGQKAFQSATALTRSSFPDGFIFGAGSSAYQYEGAAALDGRAPSIWDTFTREHPEKIRDHSNGNVAEDFYHLYGKDIPLMKDIGLDSYRLSISWPRVLPGGRISRGVNWEGVKFYNYLIDELLSNGIQPFVTIFHWDVPQALEDEYNGLLSPNIVNDYYDYVDFCFKEFGDRVKHWVTVNEPNLMSIYGYAYGVNAPGRCSDYIGNCTQGDSATEPYIVVHHLILCHSTAVRLYREKYQATQGGIIGITVFTAWIVPKYQDAACKKAASRACDFLFGWIMHPITYGDYPETMKYLVGNR... | 161 |
F7G7C3 | 2.7.11.13 | ACT_SITE 486; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MSRPGPGPRSGPVKFNGSVRVRVGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTATKQKTNGPTYNEEFRADVTDGGHLELAVFHETPLGYDHFVANCTLRFQDLLRTAGPSDAFEGWVDLEPEGKVFVVITLTGSCTEATLQRERIFKHFTRKRQRAMRRRVHQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNVNKVDEKNSEQRFGINIPHKFHVHNYKVPTFCDHCGSLLWGIMRQGLQCKMCRMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQP... | 100 |
Q9P6I1 | 2.3.2.23 | ACT_SITE 90; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MNSSIKRLHKEYASFQAGDISGLLLLKPVTDVDMFHWKAVIEGPTETPYEGGQWVLDIHVHEGYPISPPSVYFQTKIVHPNISWTNGEVCMDILKTHWSPAWSLQSACLAIISLLSNYDASSPLNVDAAKLLRTGDKTAYNSLVRCTTYLYAKGKIEDLS | 64 |
A0A022RDJ3 | 3.1.1.11 | ACT_SITE 408; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASLINPYAKVHEPDQDINLIASANRAKKRRRNIVIFTFSAIILACVVVAALAGVVVSRAKNETSRQQNESLIISSKIKAICNSTLYPSSCYTSLAPLAINSGHFNPREIFRLSIQVAIDELLDVSGKFNSSNNNMYNDNATMAAVESCLQLLSLSIDHLNSSLTVNFDLTDLVNAFDDLRTWLSMAGTYQQTCIDGFENTPFIGTVVQALQNSTEFTSNSLAIITSIEGHSVSSFGRRLMSTGSSQRREVLDKSIVPNAVVAQDGSGKYSTINAAMKDVPNKSKTRYVIYVKKGTYVENVIVSATKWNVMMVGDGMDAT... | 125 |
A0A1U7YSX9 | 2.1.1.37 | ACT_SITE 454; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MGKRKTKEEATQASASTASSRKKEKKTAEPLESRLYGEPVPAEEARERWLERYDKKQKKSKNARGSGGNKKEDTDEEVLLARCHYRQAEVDGCIFNLNDDAYVKGEEGKPNYIGRIVELFETTDGEPYFTAQWFFKAEDTVIGKDHSSLIDSRRVFLSNMRDDNPLDCIVSKIQIAQVSPNMDLVAKQRTIPSSCDLYYDMSYSPTYSTFANLSIESTRAGSETSSTISSEVSFDGAEGECKPVSEKSSSISLPTKPEIALLDLYSGCGAMSTGLCLGAAISGINLVTRWAVDLNQYACESLRLNHPETVVRNETAENFL... | 47 |
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