Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
O58801 | 2.7.1.23 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MKFGIVARRDKEEALKLAYRVYDFLKVHGYEVVVDKETYEHFPHFKEGDVIPLDEFDVDFIVAIGGDGTILRIEHMTKKDIPILSINMGTLGFLTEVEPSDTFFALNRLIEGEYYIDERIKVRTYIDGENRVPDALNEVAILTGIPGKIIHMKYYVDGGLADEVRADGLVVSTPTGSTGYAMSAGGPFIDPRLDVILIAPLLPLPKTSVPMVIPGSSRIDIRMLTDREIILAIDGQYYEHLPPNVEITVVKSPRKTKFIRFTREIYPKYTIRIKERH | 89 |
P0A7D4 | 6.3.4.4 | ACT_SITE 14; /note="Proton acceptor"; ACT_SITE 42; /note="Proton donor" | MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAV... | 253 |
W5LZG4 | 3.4.19.12 | ACT_SITE 335; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 814; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | GAGGRNAKMAADLGELLVPYMPTIRVPRTGDRVFKSECAFSYDSPESEGGLYVCMNTFLGFGREHVERHYRKTGQCVYMHLKRTIKEKDPGASGGAVPRRQNGKVFLEDVDLSCDFNGDDYEYEDEAKLVIFPDHFEIPLPNIEELPALVTIACDAVLSSPSPYRKQEPDSWEDEIQVSRHARNLKQLDNSVRIPPSGWKCARCELRENLWLNLTDGAVHCGRWFFDGSGGNGHALEHYRETHYPLAVKLGTLTPDGGDVYSFDEEEAVLDPYLAEHLAHFGIDMLQMQKTENGLPDSKAKPRISEWEVIQESGLKLKPV... | 175 |
A0A7M7NH48 | 3.1.1.4 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 129; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MDGTRALLSIILLLAVSLSLVSGDVLSMGTMIDWEDESTHSIFDVMTRFNLYGCYCGFGGQGVPVDKIDCCCRDHDECYDNLAKDGTCLSGDTGVGKVYKYTKVNNDGKHTVQCKPSSDTCAEKICACDKALAECFSTNEPYYNSANRNYNRGRLCGKQMAKSCPNFN | 130 |
W5NA58 | 3.2.1.35 | ACT_SITE 138; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | NHTLTAAMLSALALLSLWALGGALGPRQTPVPLVPDVPFLTVWNAPTEPCMSKYGVDLDLSLFNIVLNQNQSFMGDNITIFYEGKLGRYPHYTTRGEAVNGGVPQNASLPAHLRAAGADIAADIPRRGFRGLAVVDWESWRPLWARNWDTKQVYWEASRALARRGHPDWPPSRVESEAQRAFQGAARAFMEGTLRLGRAMRPGGLWGFYGFPACYNYQYKNSTANYSGECPPLEMRRNDQLAWLWNASSALFPDIYLDLALRGREDAILRFTHHRVLEAMRAAGQVGRVAPPVLPYARIAYTYSMEFLSQEDLAHTIGES... | 166 |
H3GGZ4 | 5.3.1.8 | ACT_SITE 272; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MQELKCVAQSYAWGKSGLESSVAQLKEAGDESFKADASTPYAELWMGTHPNGPSRVIREEGGESPLLSDWIRSLRANETGDLPYLFKVLSVRKALSIQAHPDIKLARELHAKFPEMYKDPNHKPEMTIALTRFEALCQFRKMDEIAAHLQAVPELRALVEVEVSQRLVTQQNEAALREFFRCFVYAESENVATQLRALRARLEGSSSLSALEKLVLRLDNEYPDDIGCFCPFLLNYITLEPGEAMFLGANEPHAYLSGDCIECMACSDNVVRAGLTPKFIDKETLHSMLTYHTGKPRVYKGDARDDGIARLYSSPVPEFE... | 214 |
Q6K2D3 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAMARVATAALMVAAAVLLGLAGAGHAQLQNGFYKGKCGANDVEAVVQGIVRARFARDAPIVAYLLRMQFHECAVNGCDGGLLIDGPGTEKTASPNLSVKGYDLIADIKAELERRCPGVVSCSDIQILATRDAVVLAGGQPYAVRTGRRDRRQSRASDVVLPAPDSTAAQTVAYFGKLGLSAFDAVLLLGAHTVGATHCGVIKDSRLYRYGGRAGATDPALDPYYAFVYKTWVCPNAAASDGNVVFLDDQWSALRVDSNYYKQLQRRRGVLPCDQNLYGDGSTRWIVDLLANSDLFPSLFPQALIKLGEVNVLTGAQGEI... | 14 |
H2XYE0 | 5.1.3.3 | ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 308; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MGHVKCSEFGKTKNGQVVNLYELKSNHVELGLINYGATIAYLKVPDRFGKRDDIVTGFDNLEDYLSCKNYFGCVVGRVANRIGEGKFHLNGQEWVVDVNNGPNCNHGGSAGFDTKVWECTSAENNSVTFRLESPHGDMGFPGDVVVTVTYILHNNELEIKYKGTSNQPTPMNLTIHSHFIKDISKWENFCDHFLNIPADHYLPTDEHCLVTGDMAPSEKTDFNLKNEPRKLTQDFLLNLPGGGYDHNFCLTRDKTKKLAAVLTHAGTSRVLKVYTDQPGIQVYTGNFLNGMKGKQGVKYTKHSAICLETQNWPNAINNPN... | 211 |
Q9KUP2 | 2.2.1.1 | ACT_SITE 412; /note="Proton donor"; /evidence="ECO:0000250" | MSSRKQLANAIRALSMDGVQKANSGHPGAPMGMADIAEVLWRSHLNHNPQNPNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEKALAAQFNKPGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWHVIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIKAAREFLGWEHAPFEIPADIYAAWDAKQAGASKEAAWNEKFAAYAKAYPA... | 51 |
O84332 | 5.3.1.1 | ACT_SITE 118; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MFTDKETHRKPFPTWAHLLHSEPSKQFVFGNWKMNKTLTEAQTFLKSFISSDILSNPQIITGIIPPFTLLSACQQAVSDSPIFLGAQTTHEADSGAFTGEISAPMLKDIGVDFVLIGHSERRHIFHEQNPVLAEKAAAAIHSGMIPVLCIGETLEEQESGATQDILLNQLTTGLSKLPEQASFILAYEPVWAIGTGKVAHPDLVQETHAFCRKTIASLFSKDIAERTPILYGGSVKADNARSLSLCPDVNGLLVGGASLSSENFLSIIQQIDIP | 213 |
D8RAX7 | 3.1.1.11 | ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYPPGTHPSRSWLRGRILATASTPFPNVTVAKDGSGQFSSISAAIAAAPTQSRTRYVIYVKQGTYVESFEVPKSKPNLMLLGDGIRKTIITGSKSVQNPGVTTFTSATVIVSGNNFLGQGITVQNTAGAVNHQAVALRVTADKVAFYKCSFEGFQDTLYAHSLRQFYSQCRIYGTVDFIFGNAAAVFLNSELVARVPMTNQKNTFTAQGRTDPSQNTGFSFQGCTVDGNADLKTAIRSFPTYLGRPWKEYSLTVFLKCYQGDVINPAGWLEWDGDFALKTLFYGEYQNQGPGSGTSRRVSWSTQITSQDQANRFSARNFV... | 125 |
F6HKE8 | 3.1.1.11 | ACT_SITE 258; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRIKTTLFFWSSAFLIALLSITVALFTISSSTATITQGDLELAFLRRIVKQSGVEDFLSLLNQATDRASQRHHHHHHHHRKPEVICDDAKWKSKIISSYNVSLILTVDLKGCANFSSVQKAVDAVPDSSLSRTLIIMDSGIYREKVVVGASKTNLIFQGQGYLNTAIAWNDTANSTGGTSYSYSVAIFAPNFTAYNISFQNTAPPASPGDVGGQAVALRVANDQAAFYGCGFYGAQDTLHDDRGRHYFRECFIQGSIDFIFGNARSLYEECTINSTAKEVSSGISGAITAQGRQSVDEKTGFSFVKCVIGGTGRVWLGRA... | 125 |
H2MFY7 | 2.7.10.1 | ACT_SITE 876; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MEKVCSFWMLLVCLVGGAAARTVAETRNKDFQESRPLIVPGYPRNTTVELGGQARLLCKVHKPAFTKVQWLKSESSSTGASQPQIKALTPLQSSSSKTKTLHLSNVTLEDAGEYICVAESSHAGETLQAMQSAWLQVLPGSTSQGLELNSADVLPAELPPRRPSLQAGLPENATAVVGSDAQFLCKVHGDSGAKMQWLKHVEINGSRFSPEGRPHVKILKTSSSDSNHGVEMEVLSLSNVSPDDAGAYTCWAENSAGFVFQTAWLTVIPDPETRRTWVQEVEVEREADLDVLEDLSEDTTEHLVLEPGDVLKLRCDVSTR... | 97 |
B3RP77 | 3.1.3.48 | ACT_SITE 85; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MFLVHGNLLWGNIDDSIGLAKENPRGISHVLTIDAQPVKELDNLSLHVKFVQALDTPFTDLLDQIEDCIQFINVGMDQGKVLVHCTAGLSRSAFVLIAYLMKMEEKPYTEAYNALKSINANMCPNVGFVQQLQLYEKLNCKIKPSDAEYRNYQLQNTARMYTVLGDVSKVKSFIRSSHHGLLNGKIVYKCRKCRSLLYSENNILTHSIGTGQGAFKWRKRNAKNNNNQQHDVSVCSSYFIQPLPWMESVIVGNVEGKLSCPKCNNRIGSFNWAGSQCSCGAWITPSFQIHRNKIDESK | 149 |
Q92398 | 2.7.11.24 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDRRHRVYRVFNQEMYVEPNFKVVKELGQGAYGIVCAARNVASKDQEAVAIKKITNVFSKSILTKRALREIKLLIHFRNHRNITCIYDLDIINPYNFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLARGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDEETLSHISSSRAQEYVRSLPKQRPIPFETNFPKANPLALDLLAKLLAFDPNRRISVDDALEHPYLAVWHDP... | 104 |
A0A0K9NN07 | 3.1.1.11 | ACT_SITE 347; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAKVVVYCIFSILVFLTAVYGGVPITSCTQLPHPAVCQSLVNNTLDLPKVGFWELNLRGAISNLRQAILATSSINTDDIDRRTKSAWEDCLALSNQSMELLENSLKYPSNEDTQTWLSTISANHGTCTDGFSDFNISVPMTILNISSGDTDKFLSNLLAINKEHIPQKSKDNHRLFPEWLDVGDQRLLSSKSVKPDLVVAKDGSGDYKTIGEAVKASVKKRKHNKRFVIYIKAGVYSENVLITKDMTKLMFLGDGIKYTVVTGKRNVVDGDTTFKSATVAAEGDGFIAKDMTFENSAGPKKHQAVAFRSSSDKSVFYQCS... | 125 |
A0A2I2ULG3 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 121; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKFLVLAALLTVGAAEGGVSPRAVWQLRNMIKCTIPESDPVRDYTDYGCYCGLGGSGTPVDELDKCCQTHDHCYSRAKKLDSCKFLLDNPYTKTYSYSCSGSEITCSDENKPCEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYCKN | 130 |
Q58574 | 6.3.4.2 | ACT_SITE 387; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 513; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 515; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MKIMKFIFITGGVISSLGKGITAASLGRLLKARGFKVNMIKIDPYLQIDAGTMSPYEHGEVFVTEDGGESDLDLGHYERFIDENLTKNNNITTGKIYWSVLTKERKGEYLGKTVQVIPHITNEIKDWIKNLGEGYDITIVEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRAAGELKTKPTQHSVKELRSIGIQPDILICRTEMPISDKIREKLALFCDVDKEAVIEARDARTIYEVPLNLEKEGLGKLVTKKLNLPDREPDLDEWRKFVDRVINPLNEVTIGIVGKYVELKDAYLSITEALIHAGAKN... | 252 |
A0A3B3HRN9 | 2.3.1.48 | ACT_SITE 387; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MTGGSAFHKNYSNNKDSEPRIGVEMDSSRPEHERGELESSMPAACSSNGSGGEEDEAEAHGRTREAGASSNQHTPEGGGVLCGGREQEVSVEIGVTYLCQRADKTWHTAEVIQSRLNEQEGREEFYVHYVGFNRRLDEWVGKSRLALTKTVKDAVRKSTEVGGVGDLGDQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIQIGNFEIDAWYFSPFPEDYGKQPKLWICEYCLKYMKYEKTFRYHLSHCQWRQPPGKEIYRRSNISVYEVDGRDHKIYCQNLCLLAKLFLDHKTLYFDVEPF... | 61 |
Q9RRQ4 | 3.5.1.88 | ACT_SITE 179; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MTAPDSSSAPAPLAFGGKPRVYPMRLYGDPILRRKARNLTAADTLHVPGFEPQTVREVADTMLETMFEERGVGLAAPQIGLPVRMFVAVEYADDEEENEGQETPLRSRVLREYVMLNPVVKVINKKKDKSYQEGCLSIPGIYEDGVPRARQVRVDYTDLDGQPRSIEAEDYLARVFQHETDHLDGKLFLDHLPADITEDHRKDLLRIQQASKNFLAQLSEWDKAQRHLKENL | 183 |
A8XP32 | 3.2.1.143 | ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 154; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 155; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | VLDQFANVVRIALSAEEILPKRIYRLTDFVESATFSHVQCAALLARMFFKPKTSHSLSFHYLLEHDDELSIEKLRFLFAYFDRIATNPPKGCVSFRLKTVRNEEFKEEWIKNKCNPMPDVRIYDQMVIEETALCTQIDFANEYLGGGVLKSGAEEIRFLMCPEMIVGMLLTDKMDDTQAISIVGAYVYSGYTGYANKLKWRPLSGRYARQNDARLRDKYGRLRVETVAIDAMYFKTKAIAEQVTSDSLTREMKKAYTGFAQSEHFGQIPIVTGFWGCGAFNGHKPLKFLIQLMAASIAGRPLQFCIFGDTVMGNKCRQMK... | 159 |
A0A1U7ZIC9 | 3.5.1.2 | ACT_SITE 78; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 202; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 204; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MAVGVLALQGSFNEHIAVLRRIGVKGIEIRKPEQLQNVHALIIPGGESTTMAKLAEYHNLFPALREFVKMGKPVWGTCAGLIFLANKAVGQKEGGQELIGGLDCTVHRNFFGSQIQSFEAELSVPELAAKEGGPQSSRGVFIRAPAILEAGPEVEVLADYPIPSKKLTDSKSVTGNQEVKIGSKDKVIVAVRQGNLLATAFHPELTADTRWHSYFLKMMAECGDQGNFSTGGDDINDNQQQLRNDLPIFQ | 181 |
A0A0A0L6C8 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKSASLLFLIMMVCLSEAVLDSHYYSKTCPNAENIILQTVYNASIHDPKVPARLLRLFFHDCFIRGCDGSVLIDSTPENQAEKDAPPNISLRSFYVIDEAKAKLESACPHTVSCADIVAIAARDVVTLSGGPYWSVLKGRKDGKISKASETINLPAPTFNVSQLIQSFANRGLDVKDMVALSGAHTLGFSHCSSFQSRLRNFSATHEIDPTLESGFAQILRNKCPKPNVDKNAGQFLDPTSSTFDNVYYKRLLEGKGVFGSDQALFVDSRTRGLVGLFAQDQNLFFKEFAASMVSLGNVGVIQNGNVRIDCRVPN | 14 |
Q09898 | 2.7.11.1 | ACT_SITE 331; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNRVNDMSPVEGDLGLQLSSEADKKFDAYMKRHGLFEPGNLSNNDKERNLEDQFNSMKLSPVASSKENYPDNHMHSKHISKLPIASPIPRGLDRSGELSYKDNNHWSDRSSTGSPRWENGSMNLSVEEMEKVVQPKVKRMATICQMFFLDHYFEQLHYLYTRKQRARLFEEQLLKEPDSRRDELVKRYNGRERVYLRKRRTRISHGDFQTITQVGQGGYGSVWLARKRDTKEIVALKIMNKSVLHKMDEIRHVLTERDILTTANSEWLVRLLYAFQDTSNIYLAMEFVPGGDFRTLLSNSGVLRDHHAKFYATEMFLAID... | 99 |
O43077 | 2.7.11.1 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSNESIYSVLDLTQVIFEDRYLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLKNSSKPKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLPPTKPYPIQKLLPQNCPEGHAKMIPCLLAWNPDVRPTAKYCKE... | 99 |
Q8TU65 | 5.4.99.12 | ACT_SITE 55; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MRVALKLAYIGTEFHGSQIQPNVETVEKELFKALRNLSIIESPKSADYTCAGRTDAGVHALGQVVAFDTEKPNLAIPRVINSELPPAIWAWAHAEVPYYFDARRSAVSRHYHYVMSGEDYDISKMREASKLLLGTHDFENFSRSNGEKSTVRTLERINVRVDGEITKIDVVGNSFLWNMVRKIVTALSMIGNGVRDNDWLLQMLNPEIYEEGIEPAPPYGLTLMGVNYGENIEWIEDDYSIRRAGEQNHKRILRHRVMAEVLEELISHE | 217 |
A0A3B3HPE2 | 2.7.10.1 | ACT_SITE 736; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MALRGFNLFAFLVVNGVFLSRQSKEEVLLDMRSLGSELGWLTLPYENGWEIVQTVVNGSPLYTYSVCNVDSSDQDNWLRTTFIQRRSGASRVSVELQFVVRDCNTFGSSSVACKETFNLFLAEADADVGTNFRKGQFRKVATIAPDEITQGNVLKVNTETKTVGSLSKKGFYLAFQDMGACVALLSARVYYKTCPSTVQSLAVFPETVADSLREVEGVCVENAIGQATPRIYCSAEGDWVVPVGQCQCLPGYETTADSCQECKPGYFKSSVSLASCQVCPRNTKPSSAGATECQCEDGFFRSPSDPPTSPCSAPPSAPRD... | 97 |
F4P3U6 | 2.2.1.1 | ACT_SITE 418; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MPSTMDILAINTIRTLAADVVQKANSGHPGAPMGCAPMAHVLFSNFICQDPQHPDWISRDRFVLSNGHGCVLQYIMLHMLGYNLSMDDLKSFRQLNSRTPGHPEANHGVHGIEVSTGPLGQGISNAVGLAMAEAHMAATFNRPGFQVISNYTYGITGDGCLQEGVQAEAVSLAGHLKLGNLIMLYDDNHITIDGDIEVGFTEDVVQRFESYGWHTQVLGDGDNDVAGIIAAIQKAKAVTDKPSLIKIRTTIGFGSVLQGEEKVHGSPLGAKDIIQLKIKFGLDPEVHFHVSDEVYKHYHDASARGAAGYNAWVKLMQEYA... | 51 |
A0A251S2S4 | 3.2.1.21 | ACT_SITE 190; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 392; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MENERKTLMEEEWNSMFPTGHQLSRAHFPPNFLFGVATSAYQVEGAANEGGRGPSIWDAFARKEGKIKDGKNGDIAIDQYHRYKEDVDLIAKLGFGAYRFSISWSRIYPDGLGTEVNKEGIMYYNNLINYLLEKGIEPCVTLYHWDLPLHLDESMGGWLSDSIITYFAIYAETCFANFGDRVKMWMTINEPLQTAVNGYFTGANAPGRCDRQSAEPYLAAHHQLLAHAEAVSIYRAKFKDLQGGEIGLVVDCGWAEALTDKEEDLTAAARVVDFELGWYLDPIFFGEYPKSMQERVGDKLPVFSQKDKELLRYSVDFIGL... | 161 |
A7EK21 | 2.3.1.225 | ACT_SITE 114; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03199" | MSFLTYGSQILFHYLEPGPLGRKEMVVFNMCAGAMMWCYFRTCHVDPGEKGWVDRVMIDGVEKENLGKVVREGQGEEIEEKNVRWCKKCDAVKPPRAHHCKRCKRCIPKMDHHCPWTNNCVSHTTFPHFVRFLFYSVVSIIVLSTFLFTRLSYVISESTLPSYLGPSTTSLTMLFIIFCSNGLSLFAMSLLLMRTIYSLATNTYMIEAWEIERHDAIIERSKTRNMRGYVYANGGRKVRVEKVEFPFDIGIWENIVQAMGTANILMWFNPFAGGPSVQSAGKWEENGFNDKEGMWPPPDPDKLGRRAGCHGVETYPLEEK... | 57 |
P37957 | 3.1.1.3 | ACT_SITE 108; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:11491291, ECO:0000305|PubMed:11583117, ECO:0000305|PubMed:12077437"; ACT_SITE 164; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:11491291, ECO:0000305|PubMed:11583117, ECO:0000305|PubMed:12077437"; ACT_SITE 187; /note="Charge relay system"; /... | MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIGGASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKVDIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIYSSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN | 128 |
A0A1U8AX79 | 3.1.1.11 | ACT_SITE 440; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGYGRLGSSESVGSIPESTLSQLEIEPTPGPPPKARGKRKLIVLALLSVLLVVATVISAGLLVGLRTKGSSGALSPVRKRPTQAISRTCSKTRYPDLCINSLVEFPGALAAGDRDLVHISFNMTLQRVGKALYGVSEIANVAMDALARSAYEDCLELLEDSMDQLSLSLNSVAPPEQGGGKGVGSTEDVMTWLSAALTNQDTCNEGLSDVSGNVKDQMQNRLSDISELVSNCLAIFASSSGNEDFSGIPIQNKRRLMTESSFQTEEELPAWLTRRERRLLEMPVSSIQADIVVSKDGTGTYKTITEAIKAVPEHSNRRTI... | 125 |
Q6C3H7 | 1.11.1.6 | ACT_SITE 64; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 137; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MSKELYANSKDDAVYSTSFGVPFPHHPYSAQRAGPTGPLLLQDTYLIDALAHFDRERIPERVVHAKGGGAHGYFEVTDDLSDITYAEPFQKAGYKCPVTVRFSTVGGERGSADSARDPRGFSIKHRTDWGNWDMVANNTPIFFIRDPIKFPHFIHTQKRDPQTNLGAGPDASHFWNYLTQNPESLHQITYMFGDRGTPDGWRHMNGYSGHTFKFISKEGKITYTQFHYITDQGVKNLSAEKAGELAGANPDSSQQDLFEAIDNGDYPSWTVYVQTMTPEQAEKFRYSILDLTKVWSHKEFPLRKVGKFVLNKNADNYFEE... | 13 |
P28061 | 3.4.25.1 | ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107" | MNQTLETGTTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTYTGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVATLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSVEDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAISAAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLGLIL | 180 |
P33570 | 2.2.1.1 | ACT_SITE 410; /note="Proton donor"; /evidence="ECO:0000250" | MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLIICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGEKAQQSWNEKFAAYKKAHPQL... | 51 |
Q6GPY3 | 1.11.1.24 | ACT_SITE 74; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MALRIPVSFLLLSPLRAVASPASRTRAMSIKVGDQLPNVQVYEGGPGNKVNIRDLFTNKKGVLFGVPGAFTPGCSKTHLPGYVAQAAELKSRGAAVVACISVNDVFVVSEWGKVHEAEGKVCMLADPCGEFAKACGLLLDKKELSELFGNQRCKRFSMVVEDGKIKAINVEEDGTGLTCSLAGNIISQL | 12 |
B5YGW5 | 5.6.2.2 | ACT_SITE 118; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MPNVLKVNIEEEMKTSYLDYAMSVIIGRALPDVRDGLKPVQRRILYAMFREGLLAGKKYSKCAGVVGEVLKKYHPHGDQAVYDALVRLAQDFNMRYPLIDGQGNFGSIDGDPPAAYRYTEARLTKIAEELLQDIDKETVPFAPNFDATTQEPLVLPARIPNLLINGSSGIAVGMATNIPPHNLNEIVDALIKLLENPQISMEELLEFVKGPDFPTGGTIYGIEGIRDLYLTGRGLIRIRAKVKIERETKGKKSKEVPLFEIEPEGKAFKEKIIITEIPYQVNKAKLIEKIAELVREKKIEGITEIRDESNREGIRVVLEL... | 222 |
Q9ZBQ7 | 3.1.26.3 | ACT_SITE 74; /evidence="ECO:0000255"; ACT_SITE 146; /evidence="ECO:0000250" | MRGTVSVPKKAEDAKADPPAKKKADTQASSHTLLEGRLGYQLESALLVRALTHRSYAYENGGLPTNERLEFLGDSVLGLVVTDTLYRTHPDLPEGQLAKLRAAVVNSRALAEVGRGLELGSFIRLGRGEEGTGGRDKASILADTLEAVIGAVYLDQGLDAASELVHRLFDPLIEKSSNLGAGLDWKTSLQELTATEGLGVPEYLVTETGPDHEKTFTAAARVGGVSYGTGTGRSKKEAEQQAAESAWRSIRAAADERAKATADAVDADPDEASASA | 138 |
A0A1U8NEB5 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAGFSPRKLSFSIIFLGLMTVLGSQAALDVHYYDRTCPEAEKIIRYTVLNASMHDAKVPARILRMFFHDCFIRGCDASVLLDSTPQNQAEKDGPPNISLRAFYVIDDAKTKLESACPKTVSCADIVAIAARDVVAMSGGPFWNVLKGRKDGRISKASETINLPAPTFNVSTLIQSFTKRGLGVKDLVALSGGHTLGFSHCSSFQARLHNFSSVHDIDPTMNPEFAETLKKKCPKPNKNGNAGQFLDSTASTFDNNYYKQLLAGKGVFGSDQALYGDYRTKWIVESFANDQSLFFKEFATSMVKLGNVGVMENGEVRLNCR... | 14 |
A0D0Y6 | 2.7.11.1 | ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MMSKCKSCNDDGFLTCPLCQKTTYCSKKCRDYDWAASHKFECKAELPKRNESDFEIVNQGYLGKGSFGCVKLARDRQTGLLYAMKIVNQIEKSDISIENLRREIRIQKKLQHPHVIQLFEFFEDEQNIYLVLEYAENGSLFGYLRKRKILPENEAFVYFFQTCLGIDYLHKKQIIHRDLKPENLLLDKDGNIKICDFGWSAEMMITQTRNTFCGTIDYMTPEMLEDKPHDQTLDMWCLGVLLYELIHGQAPFKGRNDFEKCQNILKQEQFEIKASDQVKYFITFQAKDLILGLMKRESKDRLTMDQVFAHPWMLTMAKEY... | 99 |
A0A067DSN6 | 3.2.1.52 | ACT_SITE 328; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MARAIIFFISLSQLCLLSLQSDPINVWPKPRIFSWPKPEATNLAAEFKIQAPMQTQLSSAVDRYLKLIKSEHHHHLVRPSINISSSPPLQTLSISVDNISVPLTHGVNESYSLTITSDENTAYLVASTVWGAMRGLETFSQLVWGNPSCVAVGIYVWDEPLFSHRGLLLDTSRNYYEVDDILRTISAMSANKLNVFHWHITDSHSFPLLLPSDPNLAAKGSYGEDYLYTPSDVKKIIEYGLDYGVRVVPEIDTPGHSGSWAGAHPEIVSCANKFWWPAGTKWEDRLASEPGTGQLNPLHPKTFGVMINVLENVASIFPEN... | 170 |
P27726 | 1.2.1.12 | ACT_SITE 154; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2" | MTIRLAINGFGRIGRNVLRALYTGHYREQLQVVAINDLGDAAVNAHLFQYDSVHGHFPGEVEHDAESLRVMGDRIAVSAIRNPAELPWKSLGVDIVLECTGLFTSRDKAAAHLQAGAGKVLISAPGKDVEATVVYGVNHEVLRASHRIVSNASCTTNCLAPVAQVLHRELGIEHGLMTTIHAYTNDQNLSDVYHPDLYRARSATQSMIPTKTGAAEAVGLVLPELAGKLTGLAVRVPVINVSLVDLTVQVARDTSVDEVNRLLREASEGSPVLGYNTQPLVSVDFNHDPRSSIFDANHTKVSGRLVKAMAWYDNEWGFSN... | 22 |
A0A9R1W8M1 | 3.1.1.11 | ACT_SITE 218; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLSISCARIFCDNSLLSGLCDSIIVSRFESHESQIKASMSPTDNLSMTSDHRLVQSVDKGGKVTKVDLVVAQDGSGDFSTVSKAIEASKNRRTGTDKFVIFVKSGVYVESVIVNSTMPNLTLIGEGIDATVITNNKNANDGYETYNTATFQIWGSGFVAAGITFENTAGPEKLQAVALLSASDLSAFFRCSFKGYQDTLCLLQHRQFYRECDIYGTVDFIFGDATAVLQECNIYFRKPLPGQQNTITAQGRTDSSSVTGFVIHKSRVTAAAELTLANGWVRNFLGRPWRDYSTVVFVKCYLDSLIDPQGWLPYRGSSAFD... | 125 |
F6Y6U1 | 2.7.10.1 | ACT_SITE 722; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | EFPTYFPSGQFPLITLFVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSAGTVYEAATVEVDVSASITLQVLVDTPGTFPVSGSLSTFSFLFCRGVVSMSEATNYTILFTVSIRNTLLFTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKERKSSSNNISFFTWEFSSPSLNQSPQTTLPQYSKVGNLMIRCKAVHVNLDSGSPGIRKQNEYYSTTELDTDSVCFCSSVAEHTGYYTCSSSSIQSSALGFINATNSSEDYEIDHMKSFMYMDLLSKIISCEQKALD... | 97 |
A0A2K1KT85 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGKWSSKALATIFVTLAIAMNSITPAVAHSGLKVGFYHHSCPEVETIVYNSMVQSYKANHTVAPGVLRMAFHDCFVRGCDASVLLEGPNTERTALFNRGLHGFEAVDAAKRAVESACPGIVSAADILQFAARDSVVLAGGYGWRVPAGRRDGKVSLAEEATQMNLPAPNATVSQLIRMFGAKGLSASEMVVLSGAHTIGRAPCVTFDDRVQTSPVDPTLAPNFAASLKRQCPYPGIGSTSVNMDSTTRRFDSQYYKDIIRGRGLLTSDQGLLYDSRTKRDVHANKGSAFYRNFAQAMVAMSRIEVLTGRSGEIRRQVGEV... | 14 |
Q21307 | 2.7.12.2 | ACT_SITE 193; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MERDFDLGMGRPGGLGGLGGEPIMQQMPQPAPHHPSRSSNDHNVKNLMKQAEENSGYLTLQGNRRKADLKELQFVEDIGHGSCGTVTKCRYKSVIMAVKTMPRTSNSYEMSRILMDLDVICLSFDCPYIVRCFGYFITNFDVRVCMECMATCLDRLLIRIKQPIPERIIGKLSVSIIKALHYLKTKHQIMHRDVKPSNILLDWSGVIKLCDFGIAGRLIESRAHSKQAGCPLYMGPERLDPNNFDSYDIRSDVWSFGVTLVELATGQYPYAGTEFDMMSKILNDEPPRLDPAKFSPDFCQLVESCLQRDPTMRPNYDMLL... | 108 |
Q89DE3 | 3.5.4.33 | ACT_SITE 58; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MIRGLKAPSFMDLALKTAENAGKAGEVPIGCVVVRNYEVIATAANRTLTDYDPTAHAEIVALREAAKKIGSERLVDCDLYVTLEPCTMCAGAISFARVRRLYYGAADPKGGAVESGVRFFASPTCHHAPDVYSGVGESEAARLLKEFFRERR | 186 |
Q9SY89 | 2.7.11.1 | ACT_SITE 650; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAGFNRNLTLVTTLLIFHQLCSNVSCSTSNSFTRNHTIREGDSLISEDESFELGFFTPKNSTLRYVGIWYKNIEPQTVVWVANREKPLLDHKGALKIADDGNLVIVNGQNETIWSTNVEPESNNTVAVLFKTGDLVLCSDSDRRKWYWESFNNPTDTFLPGMRVRVNPSLGENRAFIPWKSESDPSPGKYSMGIDPVGALEIVIWEGEKRKWRSGPWNSAIFTGIPDMLRFTNYIYGFKLSSPPDRDGSVYFTYVASDSSDFLRFWIRPDGVEEQFRWNKDIRNWNLLQWKPSTECEKYNRCGNYSVCDDSKEFDSGKCS... | 99 |
Q5KJE3 | 3.1.3.16 | ACT_SITE 369; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MADNDHEKLKSSLSDIITGVESPVPSFTPPSTAPEDDFTPFPSPVLSATSLAGLSLGSDGVFEPEVDDNKVITEEETAKALELKALANKAFKDKNFSKSIDFYTQAIALNPKEPTFWNNRAMSKAKMEEHGGAISDATKAVELNPSYAKAFYRRGLSQLAILRPTDAVSDFKKALAIEPGNKTIRDQLSITTKLIRRIEFEKAISVGETETASQRCLSLIESGACNLDTSSKPADMPLPIIPDDPNARYTPTKGFVEGMIESFKKGGKVPKRVAWEIILGCKAIVEKEKTLVDIVVPDGVTCDIIGDTHGQFFDVCNLLS... | 144 |
A4VCL2 | 2.7.11.1 | ACT_SITE 408; /evidence="ECO:0000250|UniProtKB:Q8IXL6" | MAVLRTMKLKERLVISLGATLVLLTLLLIVDVQMDFGVANRHLLQQQHQKIRLGNDYDGGTGGGGMLHEFKRKFLQKSNASGSKEASTQAGASQSGGATSGQDAAAGASGGAAGPGTSRSTSTRKPTPHDRYADLQKHLLSDEYSHVIVDNAPDVSRDNPTLAEMLHRKASANASNLERFQLRITKKELYGEQDTLVDAVLRDMIKLPIQHVVQKEGGTQLKLIIEYPNDIKALMKPMRFPREQQTLPNHFYFTDYERHNAEIAAFHLDRILGFRRAMPVAGRTLNITTEIYQLAEENLLKTFFVSPSLNLCFHGKCSYY... | 99 |
Q0E459 | 2.7.11.24 | ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MEFFTEYGEASQYQIQEVVGKGSYGVVAAAVDTHTGERVAIKKINDVFEHVSDAIRILREIKVLRLLRHPDIVVIKHIMLPPTRREFRDIYVVFELMESDLHQVIEANHDLSPEHHRFFLYQLLCALKYIHSANVFHRDLKPKNILANSDCKLKICDFGLARVAFNDSPSTIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGRPLFPGRNVVHQLDLITDLLGTPSSETLSRIRNENARGYLTGMQRKHPIPFSHKFHNADPLALRLLERLLAFDPKDRPTAEEALADPYFRGISKLSREPSRLPVS... | 104 |
A0A251TP05 | 3.1.1.11 | ACT_SITE 423; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDTIKSFKGYGKVDPAEEQAFRRKTRKRIIILTVSVVLLLAVIIGAVAGTLIHKRNKNNDDSTVGSNDSAQSLKAVCSQTLYPESCYNSISEINKSNSTDPEELLKLSLQVVLKSLSDVATLPDKLSSKTTNETVKKALGVCGTVLNDAVEYLQDCLSEMDVKPNEKLLTLPKVEDLKTWLSTAITNQETCIDALDEMSPNSTFVDDTKSQMKNSTEYASNSLAIVSKIAGILRKLNINFHRKMLTVTVTEPGFPEWVSPGVRRLLQEVRPTPNVTVAADGSGDVRTIKEAMAMVTKKSKSVFIIYIKEGVYKENVVLDK... | 125 |
D8S101 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGTSVRHWKQRLVLVCLALGSVCGQLAFDFYANSCPRVEAVVANAIRSATFFDSTLPPKLLRLMFHDCFIEGCDGSILVDSTANHTAEKEDESNKTVDGYAAIDSAKSALEFFCPGVVSCADIVALAAREAVIMMGGPQVQIPMGRRDGLISKVSNVRGNIPDTTLTLDQLTKVFNSKGLSQKDLIVLSGAHTVGLAHCFAFNERFHFSSNGSVKVDSTLDPGFARQLLQACPERPNPRVAVAIDPTTPNAFDNAYYRNLQNGKGLFGSDQVLFTDRRSRQAVNSLSGDSREFFGSWADSFLKLSVVHTKTGNQGEVRRR... | 14 |
Q9YI66 | 2.7.10.1 | ACT_SITE 634; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MEVSLCILLFLLHFNEGIHGVRFTQKPFHQTVTQGNMVRLGCAFEGLSEPEIIWMKDGEKLFSTDQMYITLDPYHWETFHSVKSVQQQDAGKYWCEVEYHGAIISSEPAWITVAGVPHFGVEPEDVAAFAGESFNLTCAASGPPEPVEVLWWLGGEQNGDFTPSPSVLFVKGVNESIKFHCEPRNARGISVSRTGTVHIKARPDSLGRTGHHVSDFNITLTWSPGFTGHSQLSTCTIQLSRGPGEVKLPDVVVEVPPFQHVFEGLRSYSNYSVRVRCDNEVGSSPFSPWVDFHTPQAAPSAAPKNFTFDLSEQQLTLSWA... | 97 |
D3G9N3 | 2.3.1.48 | ACT_SITE 219; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q07794" | MDNLYTGISKSIESLPPEITFSYGYIFTNFKKLKWPWLNKRKIDNVYLSNHFFFILQEDAMAYAIEVLIFFSSELSVFYISKADSTGFFNRHGSPSPLKAVISTFLSYLIRRFSRKNIPSRISLFSRSQPQYLFPSSSLNPSKHILDDRELVRWWLKVLDSVNGSQCPKKYVLIPGMDPRETLKYTPQHVDTDLNWICGHPYESMGQSAGEIIPRFPDDPKTRFLDQLDRDGEVVSIDKFWELMAFRQECIHGRIVGFFSLEFPGNDQDGTNNTITEDLDLQNGIQINEKIYRMVYEKLLRSDFETLEKSKGATLDLIND... | 61 |
A0DTL9 | 2.3.1.48 | ACT_SITE 321; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MSAKGKNKAKAFATLPNAVPTSSTKIHEGALDNSNYVLAQMKNGKWEKAKIIECRLSKDYDPKQKKVDSSYEYYVHYEFYNRRMDEWVGRERLQLTEDPIIEDTQPKKRPRPSDKREVTAENDEHEGMDQQSLITHEMHTKFKTIEKIEFGQYRCDTWYYSPFPSGYHNIDCLLICEFCLSFYIRKSELQRHQLKCVLCKLGHPPGDEMYRDTERRLSMFEIDGHKNPTYCENLCYIAKLFLDHKNLYYDVEPFLFFVLTEYNETGFHIVGYFSKEKESSQGWNLSCILTFPFHQRKGYGKFLISMSYQLSLIEGKYGTP... | 61 |
F6W446 | 2.3.2.26 | ACT_SITE 720; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | VETPCLNNRGFSRLRSTIFCAKNICKRDFFRLPDPFAKILVDGSGQCHATGTCKATLDPKWNQHYDLYVGKSDSITISVWNHRKVHKKHGAGFLGCIRIMSNAINRLKDTGYQRLDLCKQTKYDQEPVRGQIVVSIESRDLDDRSPSNPVIDARSLIPAQENDLPEGWEARMTNGRLQYIDHYTRTTQWERPTQPSTRPRRPLSALIISEPDQHQRPRISSSSGSSGPRNSSSPSVPGESDSTRFRRHKNYMTRNQLHGPSAPLPEGYEQRTTQQGQVYFLHTQTGVSSWHDPRIPRNLSHINPEDLGPLPSGWELRSTA... | 65 |
Q04958 | 3.1.1.5 | ACT_SITE 1406; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1524; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKN... | 131 |
P43637 | 2.7.11.1 | ACT_SITE 189; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVLLKEPVQPLPRSSLLYNNASNSSSRIKETRKVKLLYNPLTKRQILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDL... | 99 |
A0A9J7HW37 | 1.8.1.4 | ACT_SITE 486; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MQSWCRLSSQVARVLRVSGVHQRGPAITVAGCRHYSDAAEADLVVIGSGPGGYVAAIKAAQLGMKTVCVEKNATLGGTCLNVGCIPSKALLNNSHLYHMAHGKDFASRGIEFDGIRLNLEQMMSQKSTAVKALTGGIAHLFKQNKVTHMAGHGKITGQNEVTVLKADGGQDVVKTKNIMIATGSEVTPFPGIEIDEEAIVSSTGALSLKSVPERMIQIGAGVIGVELGSVWSRLGSKVTAVEFLGHVGGMGIDMEISKGFQRILKKQGMDFKLNTKVVSASKRDDGVVEVKVEAVKGGKEEILECDVLLVCIGRRPYTTN... | 36 |
P53349 | 2.7.11.25 | ACT_SITE 1350; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEVNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPN... | 105 |
A0A8I7BGE0 | 1.11.1.7 | ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MCGGRVLHRGFPATLVLVLAMAMACTIILLLPLSDAQLEVGFYDGSCPRAEQLVRTVVRAAIRRNPGIGAGLVRLFFHDCFVRGCDASVLLDAVPGSDDAVEKASQANSPSLRGYGVIERAKRVVERRCRRTVSCADIVAFAARDASGVLGGIGYEVPAGRRDGRASNASEVLNSLPPPFANASRLVDSFAAKGLTADDMVTLSGAHSFGRTHCSAVAFRLYPRVADDMDAAYGRSLRARCPAATGRRDRVVHLDPVTGLRLDNQYYRNVEARQVPFTSDATLLTRDDTAALVGLYARNRTAWMSRFAAAMVKMGGLDVL... | 14 |
P09769 | 2.7.10.2 | ACT_SITE 382; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ... | 98 |
F6H1N5 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | METSSFLFLLLIATAAAFVQGQGTRVGFYSRTCPQAESIVQKTVQSHFQSNPAIAPGLLRMHFHDCFVQGCDASILIDGSSTEKTAGPNRLLRGYDVIDDAKTQLEAACPGVVSCADILALAARDSVVLTKGLMWKVPTGRRDGRVSLASDVNNLPGPRDSVEVQKQKFADKGLNDQDLVTLVGGHTIGTSACQAFRYRLYNFSTTTANGADPSMDATFVTQLQALCPADGDASRRIALDTGSSDTFDASFFTNLKNGRGVLESDQKLWTDASTKTLVQRFLGVRGLRGLNFNVEFGRSMVKMSNIGVKTGTEGEIRKLC... | 14 |
Q9XTG7 | 2.7.11.1 | ACT_SITE 303; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSTENAHLQKEDIVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEPLNNFMIRDAATVCLDKPRPNMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQAVSSHNRLKENAGNTSMQEEDTNGNPSGESDVNMDATSTRSDNDFESTVMNIDEPEEVPRKNTVTMDDFDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKIT... | 99 |
A7RIU3 | 2.3.1.286 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | LDDVSFEGIARYITSGKCKNIVVLTGAGISTTAGIPDFRTPGSGLFNVLQTYGLTTARSIFEIDYFQMNPKPFFVAAKAVYPGQFKPTISHYFIKLLQNKGLLLRHYTQNIDTLERVAGITGDHLMEAHGSFHTGHCMACNKEYSQDWIRVEIMADKIPRCTECDGVVKPDIGFFGDPMPDKFYQLAAEDFPKCDLLIVMGTSLIVQPFASLIARVSVDTPRLLINREKCGYEVHGPRPGFQFELKDNKRDVAWLGTTDDGCLALAALLGWKVSKKTGRCLKSII | 58 |
T1FPC3 | 1.1.1.8 | ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MAKKKKVSLIGSGNWGTVICKILGNNILCNEHLYEKNLPMFVKKELYNGIDLCDIINEKKMNKKYMPHCFIPDNVMASSDLLEVTDRADILVFVLPHQYVREICETLKGHVKNDAIAISLIKGFDVYGNKLDLISNVIRSQLNIPCSVLMGANLAYEVALEMYSEATIGCKDEEVGILMKKLFQTHYFRIVVVDDELTVELGGALKNIVAMGAGFSDGLNGGHNTKSAVIRLGLMEMMSFSKMFFKDSKMSTYFESSGLGDLVTTCYAGRNHRVAKEFASNPQQTLENLEMNLLNGQKLQGPLTAAEVACVLKLHNVEGR... | 7 |
Q754W3 | 3.5.1.2 | ACT_SITE 84; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 193; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 195; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 244; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"... | MVQVVHIVDVESGNLQSITNAIEHLGYEVKLIRSGADPELDKAETLILPGVGNFGHFTRNMRARGFVDAISSYIASGRPLMGICVGLQVLFRSSEEDPGAEGLALVDMSLSRFRDESKPVPEIGWNTLQLDGDQFFGLDPCGRYYFVHSYAAMLANGAGRLREQGWRVATARYGDERFVAALARGNLFATQFHPEKSGKLGLQLLANFLKQQHPSIDRGSQDIELLTNDYSNYGLTRRIIACLDVRANDEGDLVVTKGDQYDVRDKQESGAIRNLGKPVELAQLYYEQGADEITFLNITSFKDCPLRDAPMLEVLRLAAK... | 181 |
P27876 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPALFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMFAETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVAASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPANIKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE | 213 |
P10097 | 1.2.1.12 | ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10009" | MVIRVGINGFGRIGRVVFRAAQRRNDIEIVGINDLLDADYMAYMLKYDSTHGRFEGAVEVQGGALVVNGKKIRVTSERDPANLKWNEINVDVVVESTGLFLSDDTARKHIQAGAKKVVITGPSKDDTPMFVMGVNHTTYKGEAIVSNASCTTNCLAPLAKVLNDKFGIVEGLMTTVHATTATQKTVDGPSQKDWRGGRGAAQNIIPSSTGAAKAVGKIIPSLNGKLTGMAFRVPTPNVSVVDLTVRLERPATYKQICDAIKAASEGELKGILGYVDEEIVSSDINGIPLTSVFDARAGISLNDNFVKLVSWYDNETGYSN... | 22 |
A0A1U8A5R2 | 4.2.1.11 | ACT_SITE 252; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 387; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSVQEFLDNHMLSRKIEDAVNAAVRAKSPDPVLFISNHIKKSVSSVITKITARQVLDSRGIPTIEVDLYTNKGMFRASSPSGNCTGIYEAVELRDGDKGRYLGKGVSRAVKNVNERISEALIGMDPTLQSQIDQVMLDLDKTENKVELGANAILAVSIAACKAGAAEKEVPLYKHIAELSGKTSTVLPVPSFTVISGGAHAGNNLAVQEIMILPVGANTFEEAMQMGSETYHQLKAIITEKYGTSGCNVGEDGGFAPNISSFKEGLDLVKEAIDQTGYNGKIKIAMDVAATNFCLGTKYDLDFKSPNKSGQNFRTGEEMI... | 200 |
A0A0K9NXK0 | 6.3.4.4 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 116; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 216; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MSFSATLIPSFFHQNRNGRSAGIANLRGLSAWIEKGNLQWSGRRGRSEVFRSASASLSVEVTAKDGMLMERIGSLSQVAAVLGCQWGDEGKGKLVDILAEHFDVVARCQGGANAGHTIYNSEGKKFALHLVPSGILNEETLCVIGNGVVVHLPGLFKEIDGLEANGVSCGGRIVVSDRAHLLFDFHQVVDGLREVELSNSFIGTTKRGIGPCYSSKVIRNGIRVGDLRNMDTFSEKLDILLRDAASRFPGFEYNKDMLKQEVEKYKRFADRLEPFITDTVNYMNQCITEKKKILVEGGQATMLDIDFGTYPFVTSSSPSA... | 253 |
A0A1U8NCW9 | 3.1.1.11 | ACT_SITE 241; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHIVLWLHLHTPTSHSLYWFLLSVIILQTTSASSNPGSETEFEKWLGWNVRNHRSKRLAADRSLVMSVLDDNLVIAEKNKVMINVSRDGSGDFKTINEALNSIPLRNTRRVILVIKPGIYREKIIIPRTMPFITFQGDANNPPTITGNDTASSSSKDGRPLKTFQSATVAVDANYFVAINIKFENTVPHTIGSKGGQAVAVRISGTKAAFYNCSFYGDQDTLYDHKGLHYFNNCFIQGSVDFIFGYGRSLYENCYLNSIAKKVASLTAQKRSSASMASGFSFKDSVVTGNGTGLVYLGRAWGDYSRVVFSYTFMDKVVRP... | 125 |
A0A2A6BN43 | 3.1.3.48 | ACT_SITE 437; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 439; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MVPRPPSREHAKRGVRALLEYTQDPQAEITNRLAQPTLFLAGTLAPQNNFDDPSLLASSSWPLLTAAGCSSTTSGLLQTTSPSNNNPSTRKGERNQSSVILNKSPGCHYAIRYSAMYSANAAPAAAAAYYQQMASSGALRNPSTAAAASLQYALGSTAAAAASAPYYGSLLSSSAAATNYDYTAAYGANYYGGFKSYPYGLNSAYQSLSSTLDASALSSFAPKGDGKKFTTSIVHDISGPGKSFTKFTEAPKNPRPKGWALRSTKKTGRYDPVARKLVDDLFEQYFSNGKTLRPDEAEKRMRERNDILPAQRMTFDQIRN... | 149 |
A0A0A0KZ72 | 2.7.1.11 | ACT_SITE 274; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MNFGVSTSMDVAAISIPSLHFSIKSSAAISLQAPRSRNACSVSLFSGFRRFGLRIISVKAEQASSRVTDDDFIIEDVPHLTDFLPHLPSYPNPLKNSQAYAIVKETFVKPEDVVAQKIVVTKDSTRGIHFRRAGPREKVYFKPDEVRACVVTCGGLCPGINTVVREIVCGLNFMYGVNDILGIEGGYRGFYSKNTLTLTPKVVNNIHKHGGTFLRTSRGGHDTNKIVDNIQDRGINQVYIIGGDGTQRGAALIYQEIAKRGLQVSVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVGSVDNGVGIVKLMGRY... | 84 |
A0A6I8N1V1 | 3.1.1.3 | ACT_SITE 220; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 244; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 331; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MRNKDRCLAKSHRPVHSTTLFISGKEVCFERVGCFRDGLPWTGTLERRFAGLPWPPEEINTRFLLYTRDNPKNFQEISAVNHATIQRSHFRMDKISRINIPGWKTDGKWQRHMCNVLLEAEDVNCINLDWLNGSLEYNTAVNNLRVVGAEVAYFIDVLMRMTTVEQVNCICVDWKSGSRTGYTQASNNIRVVGAEVAYLIDILSSKFGYSLSDIHVIGHSLGAHAAGEAGSRVNGTVGRITGLDPAEPCFEGTSVDVRLDPSDADFVDVIHTDSAPTIPYMGFGTSQLVGHLDFFPNGGKQMPGCKKNPISQIIDIEGIW... | 128 |
T1EG73 | 2.3.2.26 | ACT_SITE 717; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MASHSGRRSGQTKMRLTVFCAKNLTKKDFFRLPDPYAKVVVEGTGQCHVTECCKNTLDPKWNQLFDLYVGPKDSILVSIWNQKKAHKKQGAGFLGCVRIMSNAIQRLKDSGFQKIELQRSSTDDVIRGYVVISLSTRSSSTSTSSPPPSCHVHLHQDDVFGVWEERRFSTGRVLYLNHITRSTQWERPTSNSTTASTTTSTTTTTISTAISNSNHNSHSNNNNNTSGLNLNIDHRRPRSTRHENYLNRSHLHQTANLPDGYEQRTTAQGQVYYLHTQSGVSSWHDPRVPRDLTQICNDDVLGPMPLGWEKRMTSTGRPYF... | 65 |
Q50L43 | 3.1.1.4 | ACT_SITE 370; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q86XP0"; ACT_SITE 654; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P47712" | MWSGDRRVGMESLSPERLHGHPYQEEASVFCRLTVKILEARSLPRADLLSQADPYVTVQLPTASGMKFKTQTVTNSSHPVWNETFSFLIQSQVKNILELTIYDEDVITKDDICFKVSYDVSEILPGQLLQKTFSLNPQGPEELDVELLMERTWDPPENLITNNVLVARELSHLDVSLDRAGNTAMAAGQDKLELELMLKGSYEDTQTFFPDTAFTFSFHYMRGQDTELNGYLRGPRNSGWNSDTSVTPFNVPLMSLAAGKEMTIDIPAMKAPEGKLQLKTDCCPKELSVRLSYGLCPEEQAFLSRRKKVVAAALKQALQL... | 130 |
A7SB64 | 3.5.1.98 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MTKKRVVYFYDEDVGNFHYGPGHPMKPHRLTLTHNLVFNYGLHKKMEVYKPYRATNHDMSRFHSSDYIDFLSRVTIQNNPNLSKSMSDFNVGEDCPVFPGLFDFCSIYTGASLEGAVRLNQGICDIAINWAGGLHHAKKCEASGFCYVNDIVVAILELLKYHNRVLYVDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNHFFPGTGDMYEVGVDNGRLYSVNVPLRDGIDDQNYASLFKPVINMVIDHYQPTCIVLQCGADSLGCDRLGCFNLSTKGHGECVRFMKTFNLPMLVLGGGGYTIRNVARCWAYETSLLVDQQV... | 184 |
A0A3B6EGN3 | 1.11.1.7 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGMQSVCGGAGRWRRAVAWWGAVLVLAHLLSCGSAGLLDTNPGLAYNFYATTCPSAEATVRSITWAQVAANQALPGQLLRLHFHDCFVKGCDASILLDNAQSEKTAPPNGSLGGYPVIDAIKAQLEKACPGVVSCADIVALAARDAVSYQFKASLWQVETGRRDGPVSLASNTGALPSPSAGFNGLLQSFAAKGLDVNDLVALSGAHTIGKASCSSVTPRLYQGNATSIDPLLDSTYAKTLMNACPNNPASTSTVDLDGATPFKFDGSYYTNLQNKRGVLASDAALTQNAAAATIVNDLTNPIKFYAAFSMSMKKMGRVD... | 14 |
E1BEG8 | 3.1.1.4 | ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 111; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKGLLMLAWFLACSVPAVPGSLLDLKSMIEKVTGKPALKYYGFYGCYCGWGGHGTPMDGTDWCCWKHDHCYAQMETQDCDVLTQAYRYRVAWGFIICEHGSRCQQQLCACDQKFVYCLKRNMRSYNPLYQYFPNFLCT | 130 |
B8C5S2 | 3.5.1.98 | ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MEPQSNPLSTDPTTLEASIPKGTSRRVSYFYDAEVGNYHYGQGHPMKPHRVRMTHNLVVNYGLYKQMDVFRPRLIQSNAMTRFHSDDYINFLKVITPDNMTDFTRQLQRFNVGEDCPVFDGLFEFCQLYTSGSIGGAARLNEDNADVVINWSGGLHHAKKAEASGFCYINDCVLAILELLKKHERVLYIDIDIHHGDGVEEAFYSTNRVMTVSFHKFGEYFPGTGDVLDTGYADGKNYAINFPLNDGMDDEAYHSIFKPVMSKVMEHFAPGAVVLQCGADSLSGDRLGCFNLSVKGHAECVNFVRSFNIPMLVLGGGGYT... | 184 |
E7F533 | 2.7.10.1 | ACT_SITE 741; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MDYRRIKRVLFVNVFMNFVFISLQKKEEVLLDMVASGAELGWLTSPVKDGWEIGQQAVNGSLLYNYYVCNVEKGEQDNWLRTTFIQRNPAASRVFVELQFNVRDCNTFEAVPLNCKETFNLYTSEADADIGTAFRKGLFRKVATIAPDEISDRGKMKMNTETKVVDNLSRKGFYLGFQDIGACVAIYSVRVYYKTCPATVQSLAAFPETVAGGENQALREVAGSCVKNAISEGQPRIYCTTDGEWVVPMSQCQCESGFEALEDTCQECQPGFFKPSVSSEACKPCPKNTEPSGPGATRCSCNDGFYRAPEDPETSACFGL... | 97 |
F6QV95 | 4.6.1.16 | ACT_SITE 370; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 378; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 417; /evidence="ECO:0000256|PIRSR:PIRSR011789-1" | MAEAVFHAPKRKRRVYENYESPLPIPFGQDCDPRKEFKIFCAEMINNNVIVRGAEDIEQLYGKGYFGKGILSRSRPNFTISDPKLVAKWKDMKTDMPIITSKKYQHSIEWATKLMQRQGQDESTVHRILEDYTKPLEHPCIKRKEEVPLQDELNSKMVSKVEGTAAGEKVSVINGDPGKSTDMEDPSSQSHCLQESSGRDPLAVRSSDEHVVTGPAPLPQVHCSKQDVPLPLCGTQRDDSSQHGGLICDRGKGSDHEYVLVEEVVCDESEREDAPNEQLVQKKRLICRRNPYRIFEYLQLSLEEAFFLVYALGCLSIYYD... | 207 |
W1P9G5 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAISRAYISFLSTFFILFLLRNNGGVGATTLGYYSESCPNVEEIVKSSVEFFVSNDNSLAPALLRLHFHDCFVHGCDGSVLLEGSSSEMSAPANTGLRGFQVIMDAKAGVEARCPGVVSCADILALAARDAVVLTKGPSWEVALGRLDGLKSSASDTNDMPSPFDSISLLATKFAAKGLSLEDLVALSGAHTIGQADCHFFSYRLYNYGTTGASDPSLNSSSLNELKAICPSLSSNNRAALDKGSRQTWDNAYYKNIGAGNALLESDSKLGSDGSTGGLVSRFAGSLSEFDSTFVRSMVKLGNVGVKTKAGGGGEIRRMC... | 14 |
A0A251NK74 | 2.1.1.37 | ACT_SITE 496; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MAGKRKSKSSPSEAPPSNSASANKLKRTEEPIAKKEVAESMEKTASPPRKLKGKAVAVKDGEEPEAKFLGKPVKDTEARKRWPKRYLGKMKQVSGPNNSNQDEDAIQARGHYIKAEVDGRNIFDLYDDAHVQAGDGNEPYVCKIVEMFEAIDGTLYFTAQWYYRSPDTVIKECATIDKRRVFLSEIQDVNPLDCLVEKLNIVRLSLNVDQNEKSKLISTCKYFCDTTYLLPYSTFMNLPEENIQTGSDDSTISSEADVDRACEVNSEGADVDKACQVNSKVAQLCPVRECGKPEVTLLDLYSGCGAMSTGLCLGAQLSNV... | 47 |
Q9KPM2 | 3.1.3.3 | ACT_SITE 113; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q58989"; ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q58989" | MDMDALTTLPIKKHTALLNRFPETRFVTQLAKKRASWIVFGHYLTPAQFEDMDFFTNRFNAILDMWKVGRYEVALMDGELTSEHETILKALELDYARIQDVPDLTKPGLIVLDMDSTAIQIECIDEIAKLAGVGEEVAEVTERAMQGELDFEQSLRLRVSKLKDAPEQILSQVRETLPLMPELPELVATLHAFGWKVAIASGGFTYFSDYLKEQLSLDYAQSNTLEIVSGKLTGQVLGEVVSAQTKADILLTLAQQYDVEIHNTVAVGDGANDLVMMAAAGLGVAYHAKPKVEAKAQTAVRFAGLGGVVCILSAALVAQQ... | 147 |
Q81CI8 | 1.8.1.4 | ACT_SITE 438; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MSKLVVIGGGPAGYVAAITAAQNGKGVTLIDEAELGGTCLNVGCMPTKSLLESAEIHDIVRKANDYGVTLNTGSISIDWNQIQARKSQIVMQLVQGIQYLMKKNKIKVVKGKAKFETDHRVRVVQGNKEEVVDGESFIIASGSEPTELPFAPFDGKWILNSSHAMSLESVPSSLLIVGGGVIGCEFASIYSRLGTKVSIVEMAPQLLPGEDEDIANILREKLEKDGVKIFTGAVLKGLNNYKKQASFEYEGITHEVTPEFVLVSVGRKPRVQQLGLEKAGVQFSNKGISVNEHMQTNVSHIYAAGDVIGGIQLAHVAFHE... | 36 |
O67074 | 2.7.7.7 | ACT_SITE 162; /note="Proton acceptor"; /evidence="ECO:0000250" | MKSSPKSLKMRDNLLDGTFVVIDLEATGFDVEKSEVIDLAAVRVEGGIITEKFSTLVYPGYFIPERIKKLTGITNAMLVGQPTIEEVLPEFLEFVGDNIVVGHFVEQDIKFINKYTKQYRGKKFRNPSLCTLKLARKVFPGLKKYSLKEIAENFGFETNGVHRALKDATLTAEIFIKILEELWFKYGIGDYYSLKRLEKGKF | 121 |
Q9KJX5 | 3.1.3.1 | ACT_SITE 79; /note="Phosphothreonine intermediate"; /evidence="ECO:0000250|UniProtKB:A1YYW7" | MLTPKKWLLGVLVVSGMLGAQKTNAVPRPKLVVGLVVDQMRWDYLYRYYSKYGEGGFKRMLNTGYSLNNVHIDYVPTVTAIGHTSIFTGSVPSIHGIAGNDWYDKELGKSVYCTSDETVQPVGTTSNSVGQHSPRNLWSTTVTDQLGLATNFTSKVVGVSLKDRASILPAGHNPTGAFWFDDTTGKFITSTYYTKELPKWVNDFNNKNVPAQLVANGWNTLLPINQYTESSEDNVEWEGLLGSKKTPTFPYTDLAKDYEAKKGLIRTTPFGNTLTLQMADAAIDGNQMGVDDITDFLTVNLASTDYVGHNFGPNSIEVED... | 141 |
Q4WXI3 | 2.3.1.48 | ACT_SITE 199; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MASADGASPHVKSPTERNLKQVVLGDLLFKTWYQSIYPEDLVSKDTDRLYVCCWCFCYSCDVNSHVKHMRLCEHRTTPPGAQVYEHGGFSVWEVDGDEHKLYAQNLSLFAKLFLDHKSVFFDVATFLYYILTFTDPGNPEKYHILGFFSKEKLSWDANNLACILVFPPYQHKQLGKLLMGVSYKISAWEEDAGFIGGPEKPLSDMGARSYSRFWQERIGRRLLLDDTDASGQETQPARETRKRHSATFMTVRDIGEATGMLTEDVITALRGMGVVQPETPSKRRKAKQAADVPDHYATIRKSDLLRWMENRKVSLRDPVR... | 61 |
Q27526 | 3.2.1.23 | ACT_SITE 199; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 282; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MELWKSCIFLFLNFCIQSEGIVRTSYGNWNIPKIGDRNIPSFLIDESKNQFLLDGLPFRYISGSIHYFRIPRDRWDERLGKVRALGFNAIQYYIPWNMHELEEGNHDFSGLLDFAEFSMMAFHKYGLWTILRVGPYICGELENGGLPWWLLNKNVTKQRSSDRVFTREVENWFEILLPRVKPLLRKNGGPVLMLQIENEYGSYDACDQQYLRFLRDLTRSLVGDDVLLFTTDGSAESLLKCGTVEGVFPTVDFGPTDDAKEIENNFKLQRKFAPNGPLVNSEYYPGWLVLWGQKKQNLPSPQTIINGSQTMYSLGASFNY... | 163 |
A0A0A0KL16 | 5.3.1.8 | ACT_SITE 324; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MDEEDDKKLRKCRKKRLFGADRRKRLLRLKCCVQNYDWGVIGCNSQVARLFFLNSGRCNVDPGECYAEFWIGTHKSGPSFVVYGRDNNAVAAFGSKPLSLKDCISVDPVAVLGDKVARKWGGDLPFLFKVLSIEKALSIQAHPDKDLARSLNEAQPSIYKDDNHKPEMALALTRFEALCGFISSKELKAVLSSVPEIVELVQCADAEKFSHDSEQDGKEKVKQLFESIFSQIMSSNKGIVREAVCKLKRRLSLEKKKRQLSAKEQLILRLESQYPADVGILAAYFLNYVELKPGEALYVGPNEPHAYISGECIECMATSD... | 214 |
A0A7M7HNY4 | 1.1.1.37 | ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MAEPLRVLVTGAAGQIAYSLLYSIGKGDVFGPKQSLVLILLDIPPMMGVLDGVLMELQDCSLPLVSSIVATADPKVAFTGVDFAILVGAMPRREGMERADLLKANVKIFESQGQAINSYAKKTVKVLVVGNPANTNCLVCMKNAPSIPKENFTCMTRLDQNRAQAQIANRLSVSCDAVQNVIIWGNHSSTQFPDAAHASVDINGKKENVVAAVKNDDWLNGEFIKTVQVRGASVIKARKLSSAMSAAKAICDHMKDWWFGTPEGSWVSMGVYNNGSYYGIPADLIYSLPVTIGKGGEWSVVPGLTITDFAREKMDLTAKE... | 5 |
A0A7M7RGE3 | 2.3.1.181 | ACT_SITE 185; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MAARRLVSVLNLGHMQYRRAWELQHRLVRWQLDLLKTGGGEAHKKTQDLLLLCTHNPVYTIGIRTKGYTSADEERLKALGADFFRTERGGLITFHGPGQLVAYPILDLTHYKKSVRWYVKQLEDTVIKTCGRFGVEGQCSPHTGVWVGDSKIAAIGIHCTRYITSHGLALNCNTDLRWFNHIVPCGIEGKGVTSLTKEVKDRTVTVEDAIEPFLNSFSEQLECKLIDDDRGVLEMVETVE | 55 |
A0A078IBV7 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAIKNLLVLVILLGVLGVSVAHPKGLYLYYYKHRCPDAEAIVRRVTVQYVSHEPSLAAALLRMHFHDCFVRGCDGSILLKYPYNETERYAAPNLSVRGYEVVDAVKSALERKCPGVVSCADVLSLVARDAVIVINGPWWPVPLGRRDGRISRKSEVNLPSPLSGIAALKKKFFDKGLNTRDLVVLSGAHTIGISHCSVIHQGIYNFTGKSDSDSSMNPRYVRALKRRCNPADNRTIVMDPRSVKKFDSHYFNMVAQRKGLFKSDRTLLDDPETKSYIYTQVATAGSSFNKDFAHSMVKLGFVEILTGNKGEIRKRCAFVN | 14 |
H9GKP4 | 5.4.99.12 | ACT_SITE 60; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1" | MLSQKARYLISFQYSGTMYSGVMETPPHQATLGVQNYLEKAAEKLRPLVPVKFVISSRTDTGVHALCNTAHIDIERSGGKPPFSESVLVQALNRNLKHEPIRVLAARRVSDTFHARFSALSRTYVYRVVTGCSCPSDLPVFERNLCWVTQRGHLDLTAMQEAAGLLVGTHDFSTFRSASSELPAKNPVKTIDQLEIRPSSGFLMHHVKSSDLKFWELEFTSRSFLYKQVRRMAGVLVAVGQHRLDPECVKTLLDIRDLMAYPPSTIAPACGLFLKNVEYCEADLDTGRTEAET | 217 |
A0A3B3I9X1 | 2.7.10.1 | ACT_SITE 605; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | SEVSLCHVTFSVVWTLTLPPSPVGVVFTKHPTNQTVSQGKEVRLGCAVKGVSEPDITWMKDGEKLYSTDQVFLTLGEQHWETSHSVKSVQQQDAGQYWCEVEFHGLTFSSKAAWITVEGVPHFIQEPQDVATFPNTPFNLSCAAVGPPEPVEVQWSLGGVREEESRRSPAVLHVPGVNTSMKFYCEAKNARGISVSRTGTAYIKGEPTFSPVDLQVIWMTDSNVRLSWTPGFSGHSELSTCVVQVRPPQQVCRDSEVQVPPHLHRLPALRSHSNYSARVSCVNEVGASPFSPWLHFSTPESVPSAPPRNLTFDLLERHLS... | 97 |
A0A067DWR3 | 3.2.1.52 | ACT_SITE 345; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MPHGSVIPAIILIFSLFILQLCIASVASAGGGGNGINVWPKPRIMSWTTQPRANLLSPSFAISSPKHFYLSSAANRYLKLIKNEHHQPLVTPSLINITTSSSSALHTLFITVESLLTPLQHGVNETYTLSIPADASIANLTAHTVWGAMRGLETFSQLVWGKPNLLVASGLYVWDSPLFAHRGLILDTSRNYYGVDDILRTIKTMSFNKMNVFHWHITDSHSFPLVLPSEPDLAAKGSYGHDMQYSPDDVKKIVEFGLTHGVRVLPEIDSPGHTGSWAEAYPEIVTCANKFWWPAESNWTNRLASEPGTGHLNPLNPKTY... | 170 |
I1J3Q5 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANSLPIAVLLLLLLSPAALATAVFPDSGDSFHAVSCPQLDTIVLTTVQAALRQEIALAAGLIRIFFHDCFPQGCDASVYLMGTGADEISLGPNLTLQRRAMQLVESIRAKAHAACGPTVSCADVSALATRAAVVASGGPSYSVPLGQLDSFAPAPRDKVLDLPGPRTASVAELVATFATRGMADVADLVALSGAHTVGRSQCDSFADRSGRMDDTFSRKLAANCSKHKDRLQNLDVVTPDLFDNGYYKALTFNQGVFTSDMALIKNRTSAAIVRQFAESKEAFFAQFARSMTKLANAPRPGGNVGEIRRNCFTRNVRQG... | 14 |
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