Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
 Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
Q9SSL9
2.7.11.1
ACT_SITE 954; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKNLGGLFKILLLFFCLFLSTHIISVSCLNSDGLTLLSLLKHLDRVPPQVTSTWKINASEATPCNWFGITCDDSKNVASLNFTRSRVSGQLGPEIGELKSLQILDLSTNNFSGTIPSTLGNCTKLATLDLSENGFSDKIPDTLDSLKRLEVLYLYINFLTGELPESLFRIPKLQVLYLDYNNLTGPIPQSIGDAKELVELSMYANQFSGNIPESIGNSSSLQILYLHRNKLVGSLPESLNLLGNLTTLFVGNNSLQGPVRFGSPNCKNLLTLDLSYNEFEGGVPPALGNCSSLDALVIVSGNLSGTIPSSLGMLKNLTIL...
99
A0A0K9NGN7
3.1.1.11
ACT_SITE 434; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MATGQKILLGGVSALLLVAVIIGVVAGVMRSTNHIGDDFEMPSTNKNNINTVSKSIDSLCHITDYKDTCVDTLSTVNDDNGSPDPKSIVTAAIKATSVEFEIAFKKSKTMGDGTHDNMNKEALTDCHELLEYAIGELQDALASSERGDAEHIRRRSDDLKNWLSAVMAYQVICLDGLTHPELKTNMTKGLDKATELTKNALAITTEITNLLDSMKDALHLKDGLIGMGGAGAAAAGGGLLTAGFLKGGRKLLNSGVNDGGRYPQWFSAAERKLLRSTHSNKVKPNIVVAKDGSGNFSSIQKAIDSVPLKSTERFVIHVKR...
125
Q9LMB9
2.7.11.1
ACT_SITE 443; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MQICASIAQFLAWVSFLVLLATVGSSSSSESLLNCQPLDHHLVNPSRLLGFLRAMSSVNDFITNDKLWVVSSITDVSPPIYVFLQCREDLSVSDCRHCFNESRLELERKCSGSGGRIHSDRCFLRFDDRDFSEEFVDPTFDKANCEETGTGFGEFWRFLDEALVNVTLKAVKNGGFGAASVIKTEAVYALAQCWQTLDENTCRECLVNARSSLRACDGHEARAFFTGCYLKYSTHKFFDDAAEHKPDADQRNFIRSSFFPHLSDRDVTRLAIAAISLSILTSLGAFISYRRVSRKRKAQVPSCVNFKYEMLEKATESFHD...
99
A0A8V0YNY4
2.7.10.2
ACT_SITE 1026; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
MVFETISFVDTGALFCCVTVIHYVLPLPVCLLYLTSCGYQQQANVLNRNKTKTMACLTMANIEGSATATVHQNGDILGNTSAPKQTEPLLQVYLYYSPGKTGGDYLQFPAGEYVAEEICIVACKACGIMPVYHNMFALMSETERVWYPPNHIFHVDEATRLKLLYRIRFYFPHWYCNGTSRAYRYGIIRGSESPVLDDLVMSYLFAQWRKDFLDGWIQMPVTHETQEECLGMAVLDMMRVAKEKDQTPLAVYNSVSYKMFLPKCVRAKIQEYHILTRKRIRYRFRKFIQQFGQCKATARNLKLKYLINLETLQSAFYSEV...
98
K3YMY6
3.1.1.11
ACT_SITE 504; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSTAFSDFGPLTERRRVEKQRQQRRRVMVAAGGASVVLILIVMGGAAVAYNASVQDDDASSSSTSSPSSPSGGGSGSSLLSVSKSVKMMCAQTDYRDACEKSLSKAVNASASSPKDIVRAAVAVIGDAVGKAFDRSALATGDDPRVKAAVADCKEIYQNAKDDLARTLRGIDAGGLDEVTRRGYELRVWLSAVIAHMETCIDGFPEGGLKKNMTSAMESGKELTSNALAIIEKASSFLAALHMTGAASHRRLFSIREEEHVEKQPKVNYSGTFHGERDDSPAPASRRLFSFTEEEDMEKQPKVNYSGTFHGERGDSPAPE...
125
M5W7B6
2.3.2.26
ACT_SITE 1509; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MASRGQKRTEVDDELPADKRACSSLEFRPSSSNSSAQTHMNSMNSTPETNDHDMDTTSSASASSRSEGEHEKDSAYGSCDSDDADPRHSELRDYQRRRSSGDHGKFKRILSSLSEETDPSGQLAVLTELCEVLSFCTEDSLSGMTSDSLSPLLVRLARHETNADIMLLAIRAITYLCDVHPRSSAFLVRHDAVPALCQRLMAIEYLDVAEQCLQALEKMSREQPLACLQAGAIMAVLNYIDFFSTSIQRVALSTVVNICKKLPSECPSPFMEAVPILCNLLQYEDPQLVENVAVCLIKITERVSQSTEMLDELCKHGLIR...
65
Q39034
1.11.1.7
ACT_SITE 70; /note="Proton acceptor"
MKTQTKVMGGHVLLTVFTLCMLCSGVRAQLSPDIYAKSCPNLVQIVRKQVAIALKAEIRMAASLIRLHFHDCFVNGCDASLLLDGADSEKLAIPNINSARGFEVIDTIKAAVENACPGVVSCADILTLAARDSVVLSGGPGWRVALGRKDGLVANQNSANNLPSPFEPLDAIIAKFVAVNLNITDVVALSGAHTFGQAKCAVFSNRLFNFTGLGNPDATLETSLLSNLQTVCPLGGNSNITAPLDRSTTDTFDNNYFKNLLEGKGLLSSDQILFSSDLAVNTTKKLVEAYSRSQSLFFRDFTCAMIRMGNISNGASGEVR...
14
A0A1U8HIZ7
1.11.1.7
ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVQNKGTLRPQAMLSSLQLTLYMFLVPTSTITLLCSKFHIIALLSFMLGCSIVASASLKVGFYTQTCPSAETIVRKAVNKALSLNPGIADGLIQMYFHDCFVRGCDASVLLRSVPGNPPAEMDHPANNPSLRGFQVIDEAKAQIQAQCPGTVSCADIIAFAARDSTYKAGGIYYAIPAGRRDGRLSIIDERAFSLSSPQGRPRPGRFRSSGHPPSTTVHGGRRHKIGSFWSPLKPMASRPQIRGGMTRKMSPRSENEERPLVSSSTGDDEDGLRRWPSKQIDN
14
A0A251UMJ8
4.2.1.11
ACT_SITE 252; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 386; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MSVQDYLDKHMLSRKIEDAVNAAVRAKTADPVLFISNHMRKAVPSAITKVKARQILDSRGIPTVEVDLYTNKGMFRASAPSGAPSGMYGAIELRDGDKATYLGNGVSKAVKNINEKISEAIVGMDPILQNQIDQAMIDLDKTEKKGELGANAILAVSIAACRAGAAEKEVPLYKHIADLSGGGNHVLPVPAFTLISGGKHAGNNLALREIMILPVGAQTFEEAMQMGSETYHHLKAVIAEKYGPHGCNVVEDGGLAPDITSFREGLDLVMEAIGRTGYTNKLKIAIDVAATDFCIGSKYDLDFKSPKKSGQNFKSGEEMI...
200
Q8DLL7
2.2.1.2
ACT_SITE 134; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MNLLEQLRQMTVVVADTGDILAIQKFTPRDATTNPSLITAAAQMKEYQSIVDETLRQAKADLGSGATSREIVSLAVDRLAVAFGLKILQIIPGRVSTEVDARLSYDTAATVQKARELISQYEAAGVGRDRVLIKIAATWEGIRAAEILEKEGIHCNLTLLFGFHQAVACAEAGVTLISPFVGRILDWYKKKTGRAEYPGPEDPGVISVTKIYNYYKKFGYPTEVMGASFRNIGEIIELAGCDLLTISPALLQELQNTTGELKRKLDPAIAATLDIEKVAMDEATFRKMHAADEMASEKLEEGIKGFTKALETLEDLLRRH...
52
Q9AK79
3.5.4.33
ACT_SITE 50; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
MRLALAEAGRAAAGGDVPVGAVVLAPDGRTVLSAGHNEREATGDPTAHAEVLAIRRAAGELGEWRLSGCTLVVTLEPCTMCAGALVQSRVDRVVYGARDDKAGAAGSLWDVVRDRRLNHRPEVIEGVLADDCARLLTDFFRDR
186
H2MRI0
3.1.3.1
ACT_SITE 113; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MLSALLIICSCLSVRSSGKPMFPENEKSPAFWNNGAQKTLKEALSTQELNKNKAKNLILFLGDGMGVPTVTAARILKGQLNGQSGEEYQLEMDKFPFVSLSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRSQCNTTKGNEVTSILKWAKDAGKSVGIVTTTRINHATPSAAYAHSVDRDWYSDNEMPSEALQAGCKDIARQLFENIPNIDVIMGGGRKYMFPKNMSDVDYPGVAKYNGVRNDGRNLVQEWIDRMKDQGGHYVWNKQQLLSLNPKKTSYLLGLFGPVDLPYDLERNADSDPSLTQMVEVAIK...
141
Q8AV69
2.7.10.1
ACT_SITE 612; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000624-1"
MSRTRSQNGGIGCALLGLLVAAILLPVQASGEMEIPDLNDPLGQMESHDRLGATPRGYYLTFLEPVNNITIVQGQAATLHCKVSGNPLPNVKWLKNDAPVVQEPKRITIRKTDYGSRLRIQDLDTTDTGYYQCVATNGIKTITATGVLFVRLGPTNSPNPNIQDDYHKDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDDQTSKPRELCRDECEVLENDLCRQEYNIARSNPLILMQLHLPNCEELPLPESPEAANCMRIGIPVEKLNRYQQCYNGTGTDY...
97
I7GQA7
3.1.1.4
ACT_SITE 73; /evidence="ECO:0000250|UniProtKB:P00630"; ACT_SITE 103; /evidence="ECO:0000250|UniProtKB:P00630"
MHALRSSVLALWLCLHVSVRAWMTYRSANGLDEYEPEDRIIFVGTKWCGNGNVAEGPEDLGSLKETDACCREHDMCPDLIEAGQSKHGLTNTASYTRLNCACDEKFYNCLKNSSETGSGAVRFTYFTLLGTMCYRNEHPLICVKKGWFSCSKYELDQSQPKRYQWFDVSSNFAFPRMLT
130
A0A0Q3ECI8
1.11.1.7
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTMATAMVAAVLLLLTISPAAAAALSPHFHADSCPELESIVRTSVEAALEEEIALAAGLLRVFFHDCFPQGCDGSVFLTGRNSEQSLGPNLTLQPRALQLVDAIRAKAHAACGPTVSCADISALATRDAVVFSGGPNYTVPLGNLDSLTPASAKAVMTLPSPITSSVAALFEAFRTRGLVELTDLVALSGVHTVGRAGCRFFADRSAKQDDTFSKKLAANCSVEPDRLQNLDVITPDVFDNGYFKALMFNQGVFTSDMALVKDKDTAPIVKRFAGSKDKFFKQFVKSMEKLVNAPRPDGNVGEIRRSCSSPNGDDGEKED...
14
G7L465
2.7.11.1
ACT_SITE 263; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 280; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MGNKEDDDELDYEYESCLGSRRPNAHGGRGSHSSTLQPLSNRNQRFSNRIRASPLEEWEGRTNIGMSNTVTTEIRGSLMHMSIGKTKTTGKVDRATVENAIDLRTRMAIFKMINNNLFQHINGCISTGKEANVYHATDSDGQEYAIKIHKTSVLGFKDRNKYVKGDRRFERAYCSRNPREMGKTWAEKELKNLYRIAAKGIRCPKPRHQKLHMVVMDFIGKDGWAAPRLKDADLSLGKLLEGYVEIIVAMRDLYQKCRLVHGDLSEYNILYYEGHLYIIDVSQAVDIDHPCAHCLLFEDCKHVSDFFKKHGVGVMTKTEL...
99
A0A5F7ZBJ6
2.7.11.1
ACT_SITE 248; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037014-1"
MSPEGARRPGPRPSPRAVPHSPAADVGGASVAMVTNPGPGPPPPPCPGPLTSAHVSGGARLAGPCGAGGKERRSKLSGRRPSQAALPALPLARPRSCPPCLAAGPSMVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGA...
99
K3YC04
1.11.1.7
ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAAATSNALDAGYYAATCPDAEAIVSNAMSRLHYNDPTLAPALIRLLFHDCFVRGCDASVLISPTPRYSSERAAIPNHTLRGFPAVDAVKRALEAACPGAVSCADALALMARDAVSLLGGARYGVALGRRDGTQSNPWEVDLPAPFARLDDVLAYFAARGFSAEEAVVLLGGGHTVGGAHCGSFRYRLTQPDGTMDEQVRCEMLDACGAADLPLDTDPATFLDPDTPFAVDNNYYAQLMVNRTLLQVDQEAATHHATAHHVAYYAASNDAFLQRFAEAMEKLSNVGVLEGDAGEVRKVCSRYNT
14
E9H813
2.7.11.1
ACT_SITE 250; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 267; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MSDDDCYDWQYGKKNYVQNQGPQIKVQGAQPNQQTSSNKVVSFQPREKLFKKYSQKINVDEFKMPSLPGDDKVRLRDKADRATAEQVMDPRTRMILFKLMNRGFITQINGCISTGKEANVYHATGKDDTHLALKIYKTSILVFKDRDKYVTGEFRFRHGYCKHNPRKMVRTWAEKELRNLLRLEAAGLPCPKPILLRSHVLLMTFIGDAGWPAPRLKEVELSESKARELYRDTIILMRRMFHDCRLVHADLSEFNMLYHEGKAYIIDVSQSVEHDHPHALEFLRKDCTNITDFFKRNGVCVMTVKELFDFVVDLTINETN...
99
Q9MAM1
2.7.11.1
ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSGSRRKATPASRTRVGNYEMGRTLGEGSFAKVKYAKNTVTGDQAAIKILDREKVFRHKMVEQLKREISTMKLIKHPNVVEIIEVMASKTKIYIVLELVNGGELFDKIAQQGRLKEDEARRYFQQLINAVDYCHSRGVYHRDLKPENLILDANGVLKVSDFGLSAFSRQVREDGLLHTACGTPNYVAPEVLSDKGYDGAAADVWSCGVILFVLMAGYLPFDEPNLMTLYKRICKAEFSCPPWFSQGAKRVIKRILEPNPITRISIAELLEDEWFKKGYKPPSFDQDDEDITIDDVDAAFSNSKECLVTEKKEKPVSMNAF...
99
W1P3F2
3.4.21.92
ACT_SITE 184; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 209; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MAHSCVATAGSGIKLHLNHSKQSQNPVNLPFVKLPTGKQNSICSKKKILSSPRATYSGGYWTPECDSRKGIWSVRDDLHIPSSPYFPIAQAGQGPPPMVQERFQSVISQLFQHRIIRCGGAVDDDMANVIVAQLLYLDAVDPYKDIVIYVNSPGGSVTAGMAIFDTMKHIRPDVSTVCVGLAASMGAFILSSGTKGKRYSLPNSRIMIHQPLGGAQGGQTDIDIQANEMLHHKANLNGYLSYHTGQSLDKINQDTDRDFFMSAKEAKDYGLIDGIILNPLKALQPLPAAPAEESP
179
A0A804KKD7
2.3.1.181
ACT_SITE 197; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1"
MVDIVDHYICFLFQLKIHHMRLQRSLGACKFGIINYFDALKLQERLASDRKSGKILDTILSLQHPPTYTLGKRRTDHNLLVSEADLKTMGAELHYTERGGDITFHGPRQAILYPIVSLRDIGCGARNYVEGLESVMIEVASFYGVNAHAGKTGETGVWVGDRKIGAIGVRISSGITSHGLAFNIDPDLSYFKHIVPCGIPDKGVTSLKRETEMELPPDEVIHEQLIHCFAKVFRFSDIQWKTQ
55
A0A2R6X1V0
1.11.1.7
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAFTSLNIHLLPVFVFLLSTVGVDAGAAYLSNGLQNDYYRHSCPTAESVVRRVVRANVSDPSNPNNLRFAAGLVRMSFHDCFVEGCDASVLLNGLGTEKTARINKFLQSSEIIDKAKQELEKVSPGVVSCADILQYAARDSVVALNGSSWKVQGGRRDGCVSRADSADSEIPSPDLDLDGLTASFNRKGLSRDQMVILSGAHTSAAGHCENLVTRLYNFNSTHATDPSIPAAYAAQLKSLCPQRTFNDSVFIVLDTVSPFFDAGYYVTLEQHQGLFTSDQILFDDPRTRPLVESLTDNKLFEKDFGEAMRAMAAVEVKLY...
14
A0A0K9P060
1.11.1.7
ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MFSRKTVCSISMFMIFMFLVSSISTISLDFYHDSCPHAETMVREIVRSASEKDSTVPGKLLRLLFHDCMVEGCDGSVLIKGNETERSDPANETLGGFEVVDSAKRMLEFVCPETVSCADIVVLAARDAVELTGGPSVTIPTGRRDGLRSTSNSVQPNLIDTTFSLTESLRIFSAKNLTTTDLVTLSGAHTIGSSHCTSIIDDRFQTDPDTGKISFLPSVDSSLNKSFADDLSHQCNSMKSDAVVKNDLKTGMVFDNVYFSNLLEGKGLFLTDTVLADDERTAELVNVYARDEKEFFDRWQESFLKLGSIDVKTGDQGEIR...
14
Q57532
5.6.2.2
ACT_SITE 130; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897"
MTDITLPPGDGSIQRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCVSGNSLVRLLFGKSIRIGDIVTGAQFNSDNPIDLKVLDRHGNPVVADYLFHSGEHQTYTVRTTEGYEITGTSNHPLLCLVNVGGIPTLLWKLIGEIRSGDYVVLQRIPPVEFGPADWYSTMEALLFGAFISGGFVFQDHAGFNSLDRDYFTMVVNAYDTVVGGLRCISSRITVSGSTLLELDVYNLIEF...
222
P25390
2.7.11.1
ACT_SITE 1158; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MMMDILNTQQQKAAEGGRVLAPHTISSKLVKRLSSHSSHKLSRSDLKALGGSETISDGPSQLTFKDRYVFNESLYLKKLKKTALDDYYTRGIKLTNRYEEDDGDDEIIRLSNGDRIDEDLHSGVKFFSTTPYCRKMRSDSDELAWNEIATERFKWQSMLARVLKGDIVKGEKTRIANQVKKPGLNKELSDEIWLELKAWLNGRTMQEMEQSLTYLRDSSDSVFEEIMKFQIPQGKILSLDALEAILQDLMNRYHSVVSYWPNLKKMYKDKPITNTAEFTARIDVMNSWLNFKTNLTLRRQELDDWINRFSPISSSDNCQE...
99
D8T0X9
2.3.1.41
ACT_SITE 165; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000447-1"
RDRRVVITGMGLVSSLGNDPDTFYDNLLEGNSGISEIQNFDCQEFPTRIAGEIKDFSADGWVAPKFSRRMDKFMLYLLTAGKKAVANAGIAGDGSVELDKSKCGVLMGSAMGGMQVFNDAIEALRVSYRKMNPFCVPFATTNMGSAMLAMDLGWMGPNYAISTACATSNSCILSAANHIIRGEADVMVSGGSDAAIIPIGLGGFVACRALSQRNDDPSKASRPWDRDRDGFVLGEGAGALVLEELEHAKRRGAEIYAEFLGGSLTCDAYHVTAAHPEGTGMLLCIEKALDQSGVRRDDVNYVNAHAASTRSGDVQEYKAI...
60
A0A2C9UH80
5.1.3.3
ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 325; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MGKFCLVFCISILVAFGEVINGYQEEEKIGVYELKQGDISLKLTNYGARIISLFLPDKNGKLDDVVLGYDSAQDYKNDTSYFGATVGRVANRIAGAQFTLNGTQYKLVPNEGKNMLHGGPKGFSKVVWKVKKYKPDSRSPHIIFIYHSLDGDQGFPGNLRVAVGYTLIGNKLSITMKAKAKNKATPVNLAQHAYWNLAGQNSGDILSQELQLFASHYTPVDNQLIPTGKIVSVKGTPYDFLKPYTIGSRIKQLANGYDINYAIDDSEKKKKTMMKKVAIVKDKKSGRAFELFSNQPGVQFYTSNSLTQKGKGGFVYKPHA...
211
A0A2C9UBE0
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVMETKTLLFSTLPRLSYVLILVLFSLVAAAASGSLSFNFYAASCPTVEFIVVNTVRSASSSDPTIPGKLLRLVFHDCFVEGCDASVLLQGNGTEQSDPANKSLGGFAVINSAKRLLEIFCPETVSCADILALAARDAVAITGGPMIQIPTGRRDGRESLVANVRPNIVDTSFTMDDMIKIFSSKGLSLEDLVTLSGAHTIGAAHCSAFSDRFQEDSHGKLKLIDSFLDTSYARELMSMCPAGASPSITVNNDPETSSAFDNQYYRNLLAHKGLFQSDSVLLEDERTREQVKDFANDEGRFFESWRQSFLKLTSIGVKTG...
14
A0A1S4H8S9
2.7.11.13
ACT_SITE 465; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000550-1"
MADDDNTLEEIPEAENKMALRNRGRKGALKKKNVYNVKDHRFIPRFFKQPTFCSHCKDFICGFQAVFCHLGFGKQGFQCQVCSFVVHKRCHEYVTFKCPGADKGADSDDTRTKHEFKEWTYSSPTFCDHCGSLLYGLIHQGLKCTACDMNVHKRCEESVPNLCGCDHTERRGRIQLTITYAAGKLNIEVKQGRNLIPMDPNGSSDPYVKIKLIPDADNVKKKTKTIRASLNPVWNETLIFDLKPEDKDRRLLIEVWDWDRTSRNDFMGSLSFGISEILKNPVDGWFKLLTQEEGEYYNVPVPEEGADLVQLKSQMRKIPM...
100
P56518
3.5.1.98
ACT_SITE 140; /evidence="ECO:0000250"
MASTGTKKRVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLILNYGLYRKMEIYRPHKAVMEEMTKYHSDDYVKFLRTIRPDNMSEYTKQMQRFNVGEDCPVFDGLYEFCQLSSGGSVAGAVKLNKQQTDIAINWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPLRDGIDDESYDKIFKPIMCKVMEMYQPSAICLQCGADSLSGDRLGCFNLTLKGHAKCVEFMKQYNLPLLLMGGGGYTIRNVARCWTYETSTALG...
184
O97161
1.11.1.24
ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MVLLPNRPAPEFKGQAVINGEFKEICLKDYRGKYVVLFFYPADFTFVCPTEIIAFSDQVEEFNSRNCQVIACSTDSQYSHLAWDNLDRKSGGLGHMKIPLLADRKQEISKAYGVFDEEDGNAFRGLFIIDPNGILRQITINDKPVGRSVDETLRLLDAFQFVEKHGEVCPVNWKRGQHGIKVNQK
12
P08096
5.6.2.2
ACT_SITE 835; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01384"
MSIDADFSDYEDEASGDENVLPNTTTKRKASTTSSKSRAKKASTPDLRQTSLTSMTASEQIPLVTNNGNGNSNVSTQYQRLTPREHVLRRPDTYIGSIEPTTSEMWVFDSEKNKLDYKAVTYVPGLYKIFDEIIVNAADNKVRDPNMNTLKVTLDPEANVISIYNNGKGIPIEIHDKEKIYIPELIFGNLLTSSNYDDNQKKVTGGRNGYGAKLCNIFSTEFVVETADKERMKKYKQTWYDNMSRKSEPVITSLKKPDEYTKITFKPDLAKFGMDKIDDDMVSIIKRRIYDMAGTVRETKVYLNNERISISGFKKYVEMY...
222
C5YZ25
2.7.11.1
ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MAAREEEWSMSDFEIGRYIGEGKFGKVYLAREKQSGYVVALKVIFKAKLEKYRFHAQLRREVEIQRDLDHPNVLRLFTWFHDEEKVVLVLEYAARGELYKVLRAAGRFDERTAATYVASLAGALAYCHKKGIIHRDIKPENLLLDLEGRLKIADFGWAARSDAKRHTLCGTIDYLAPEMVEKKAHDHAVDNWTLGILCYEFLYGSPPFEADEQDDTLRRIAKVDWAFPATPRVSSEAKDLISKLLVKDSSKRLCLEDIMKHPWIQKNAEPSGSCIKRKDVTGAKVNEK
99
Q6CCT1
2.4.1.18
ACT_SITE 333; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q04446"; ACT_SITE 398; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q04446"
MTLQVCKDDPWLKPFEEELLRRQALVGQWKDHFAKEGGLAEFAASYKRYGLHVNKDNSVTYREWAPGASEAVLTGDFNGWDRQQYHMTRDEYGLWSVTVPPTSDGQVAIPHNSKVKLALKTSNGQWVDRLPAWSTYVVQDLSKSPIYEAVFWNPPESEKYQWKNKSPPTPANAQIYEAHVGISSSEPRVGTYKEFTKNILPRIHKLGYNVIQLMAIMEHAYYASFGYQVTSFYAISSRYGTPEDLKELIDTAHGMGITVLLDVVHSHACKNVDDGLNNFDGTDHQYFHGGAKGDHPQWDSKLFDYGKYEVLRFLLSNLRF...
73
P72797
2.2.1.2
ACT_SITE 136; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MGKNLLEQLRQFTVVVADTGDIQAIETFTPRDSTTNPSLITAAAQMPQYQEIVDSTLLKAKDEAGENASIKDIVRLAFDRLAVAFGLKILQIIPGRVSTEVDARLSYDTEATIAKARYLIGEYAKAGIDKKRILIKIASTWEGIKAAEVLEQEGIHCNLTLLFGLHQAIACAEAKVTLISPFVGRILDWYKKSTGKEYDSHEDPGVQSVTTIYNYYKRFGYKTEVMGASFRNIGEIIELAGCDLLTISPQLLDQLRNTEGDLPRKLDPATVPQDIEKIVMDKATFDKMHAEDPMASEKLAEGIAGFTKALEVLEHLLEER...
52
P9WG35
1.11.1.24
ACT_SITE 60; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P0A862, ECO:0000255|HAMAP-Rule:MF_00269, ECO:0000305|PubMed:16884737"
MAQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRGKSVLLNIFPSVDTPVCATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTENVMPASAFRDSFGEDYGVTIADGPMAGLLARAIVVIGADGNVAYTELVPEIAQEPNYEAALAALGA
12
A0A3Q7ESX1
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSKALALVVVLFFVGFFGECYGELRVGFYKGKCGITDVEVVVKKVVETWHFTKREKDIAAALLRMQFHDCFVNGCDASILLDGNNSEKKAGPNSSVRGYKLIDAIKEALEARCKGLVSCADIISLATRDAVVLSGGKWYNVETGRRDGKVSLASNVDLPSPSISVSDSIKVFGKKKISPIDMVYLLGGHTVGNTRCSLIQDRIYNFNNTGVRDPTMSNWLFSELIKKCPRVSSFDNNVPLDMKTPSFVDNSFFGEIQKGNGVLKIDQQLALDGLTKKIVGDIVKDPNFFTNFGEAMVKLGRVEVLIDGQGEVRTSCRVVN...
14
F4P7E9
1.1.1.37
ACT_SITE 177; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MVKVAVLGAAGGIGQPLSLLLKGNMSVTELALFDIVNTPGVAADLSHINTPAKVTGYVGDEQLADALKGAHIVVIPAGVPRKPGMTRDDLFNINAGIVKNLAIGCAKNCPKAFIAVISNPVNSTVPIVAEVFKQHGVFDFRRIFGVTTLDVVRAASFVSEIAGTAAASTNVAVIGGHSGATILPILSALPHQFTDAQRDALVQRIQFGGDEVVKAKNGAGSATLSMAYAGARFVNSLLEASVHKKTGIKECTYIKTDVAAADGLEYFSTVVELGVDGVAVAHPLPNLSAHEKVLYTAAAAELKANIQKGVDFVAKASL
5
P51784
3.4.19.12
ACT_SITE 318; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:15314155, ECO:0000305|PubMed:28992046"; ACT_SITE 888; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
MAVAPRLFGGLCFRFRDQNPEVAVEGRLPISHSCVGCRRERTAMATVAANPAAAAAAVAAAAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFM...
175
A0A9R0HST2
2.7.1.11
ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MEPKIVTGEGGYALDDVPHFSDYLTNLPTYPNPLQTNPSYSVTKQYFVDFDDTVVQKAVQHKDGPRGIHFRRQGPRQKVYFKPDEVTACIVTCGGLCPGLNTVIRELVCGLDYMYGVKNILGIECGYKGFYARNTLPLTPKTVDSIHKRGGTILGTSRGGYVTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYQEVRKRGLKVAVVGIPKTIDNDIPIIDKSFGFDTAVEEAQRAINAAHTEAESVENGIGLVKLMGRDSGFIAMFATLASRDVDCCLIPESPFYLEGEGGLYEFIGRRLRENGHMVIVIAEGAGEKVE...
84
G7JYI0
2.1.1.37
ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MDEKRKTRSKTPTFNNAVTADSVFDEAVSVNTGSSFGNTVRKSRRLTKCRKTTKSSSSISPGDCVNVSDDSTSGKNRKKSKKKTRMDNDKSVVASSIGEKKPKSETVPMNVDGGDDEVSNSKFLRDPILLKEAKLRWPKRYLEKEKKKTRSRSNSDEDEVLQARCHYTEAKVDGGVIYKLYDDAHVKGEKDDYHFICKIMEMFEAVDGELYFTPKRVFLSEVQDDNPLDCLVEKLTIALLELKKDFDATNDVIPPCKYYCDTLYLLEISSTISNETEVNAKSEVDSKSAITDINDDKKKPELKLLDLYSGCGGMSTGLCQ...
47
A0A1Z5SAV5
3.2.1.52
ACT_SITE 360; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MAASPYFLLLLLFLFHPLAALAPLAPSPSPSPSQPSPPRSQPPPPRVPQQVQVWPKPVSISWPLPVYAPLSPSFSIRASPSHPSLRHAIAYYTRLIRTERHAPIMPPVNYTIAGVPIRLLALSVSDPDTKLGPGVDESYTLSVPPNSSSADISAATPWGVIRGLETFSQLAWSSSAAAAGGQPIVPSDLEISDHPLFTHRGVLLDTARNYYPVGDILRTIRAMAANKLNVFHWHITDAQSFPIVLPSVPNLANLGSYSPTMRYTEQDVRRIVRFAESFGIRVIPEIDMPGHTGSWAAAYPEIVTCANKFWAPKAKPALAA...
170
A0A2K1ZQM0
3.4.21.92
ACT_SITE 175; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 200; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MALSFKITELNPLNPNKIPNSSQTLKPRYPSLNFSKSNPKPKSTAMKALFSSAKLITSTTKTKPSFLLTPKISTTRAYSLIPMVIEHSSRGERAYDIFSRLLKERIVCINGPIDDDTSHVVVAQLLFLESENPSKPIHMYLNSPGGQVTAGLAIYDTMQYIRSPVTTICLGQAASMASLLLAAGAKGERKALPNATIMIHQPSGGYSGQAKDMTIHTKQIVRVWDALNQLYCKHTGQPLDVIQKNMDRDYFMTPEEAKEFGIIDDVIDQRPMTLVTDAVDDEGKQKDSS
179
B3SBA4
2.3.2.26
ACT_SITE 568; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MSIIIIVYENPQLQSPEYFENVLPRLCQLVRSLSLPAKAELVRFWAKFNESQMLQLVISLQQYLTCTVVNILACSDTDILTSIDISLSNILYNLDMLYLANCLGGITRQSNLAHSEIVTNQASTTANADARSDQVGVFMRTVGGLRRKQDIRHHELQRLLNIDPAICRRPIVTFSAFYNEALSDAIDPRYDYRRFTVNDICLLDFPCVIMPFNKTQYLSLDCRLRQNDEIGAAIILSLLNRDVPNPFLIIRVRRDHLIEDALWQLEHVSDDNPSALLKQLRIKFVGEEGVDDGGLSKEFFVLINQEIFNPEYAMFRYNEK...
65
A0A7M7PHL4
2.3.2.26
ACT_SITE 1158; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MMSGHGETLAGHRRPPVGPGAIRKKSIPTTCTTIDKGTGRLKLTRQLSTSQPKLEGSVRRGSLDSILIDGRARSNSLAKLTDLKRNLSASNLAALSDSNLSVQEAEPQRGYDAPNTTGSKAKHYLEQFIKRYYYQLTEGCGRRECRNKFCRSSEDAIRMTPDVAAIISIQLASSQRLYFCSSEKFIGRALPEDVFQAKNSKVKSFLQTLYSSSPFATLFKDVPQPESFSTTTNSAATNSNKNIATFRHSKSDLEKLGSGQPQTFPGQLKKNRLPVKLMRKPPTGRQSSPVTNLPPSGRHQLPGTRAGSNPSMLAQRVGSL...
65
A5I7Y9
6.3.4.4
ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"
MSAFIVLGAQWGDEGKGKMTDYLAENADVVVRFQGGNNAGHTVVVGEKEYKLHLIPSGILYNDKLNVIGNGVVLDPKALFEEINYLESLGVEITPDRLIISDRAHVIMPYHRILDGIKERARGNKDIGTTGKGIGPSYTDKMERSGIRVCDLIHKEVFEENLKETLEVKNKIITEIFGGRALDYNEIYNEYLGYAEKLRPFVKDISVIVNKKIKDGKEVLFEGAQGTLLDIDYGTYPYVTSSSTIAGGVCIGAGVGPTAITNAVGIAKAYTTRVGKGPFPTELLDSTGDWVREKGHEFGVTTGRARRCGWLDLVILKTSA...
253
A7F2A7
1.1.1.205
ACT_SITE 354; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156"; ACT_SITE 465; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156"
MSPQANGESKPTASDFLAPTKDILDATKALEILKEYESRDGLSINDLIDSKKHGGLTYNDFLVLPGYIGFAASEVVLDSPVTKRITLKTPFVSSPMDTVTEHDMAIHMALQGGLGVIHHNCSADEQAEMVQKVKRYENGFILDPVVLSPQATVAEVKALKEKWGFGGYPVTETGKLGSKLVGIVTNRDIQFEDDDSATVASVMVTDLVTASYGTELVEANAILAKSKKGKLPIVDKNGNLVSMISRSDLNKNIHYPLASKLPDSKQLICAAAIGTRPEDKIRLQKLVDAQLDIVILDSSQGNSMYQIEMVKYIKEKYPDL...
3
A8E2V8
3.1.1.4
ACT_SITE 63; /evidence="ECO:0000250|UniProtKB:P06859"; ACT_SITE 105; /evidence="ECO:0000250|UniProtKB:P06859"
MRTLWIMAVLLLGVEGSLMQFEMLIMKLAKSSGMFWYSAYGCYCGWGGQGRPQDATDRCCFVHDCCYGKATGCDPKKDVYTYSEENGDIVCGGDDPCRKEVCECDKAAAICFRDNMDTYNSKTYWMFPAKNCQEESEPC
130
A0A2C9VHJ4
3.1.1.11
ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MMSKVVVSAFSLILVVGVVIGVVAVVQKSGNSEETLSTSSKNVASICQPTDYKEACEKSLGSVEDSSDPKEYLAAAILSTMEAAKKAFNLSDSLIVKAGSSDNDTKMALEDCKSMLDDAVEELQDSFSSVGESDVHTMNKRVADLQNWLSAVITYQSTCLDDFGDPNSEYKTEMKDGMLDANQLTSNALAIVNGLSKILSSFGLKLDADNDSNNHSRRLLSMGDDGYPDWYSGSGRRLFATQDISTIKPNITVAQDGSGDVKTIMEALGKLPPKYDGQYIVHVKAGVYKEYVSVGKKMHNVFMYGDGPLKTVVSGDRSNK...
125
Q57YL8
2.2.1.1
ACT_SITE 410; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MSFNDNLATNSIRCLAADGVQQAKSGHPGAPMGMAPIAYVLWSEVMKFDSKDPEWIDRDRFVLSNGHASMLQYVMLHLSGYDLSMDDLKKFRQLNSRTPGHPERGVTPGVEVTTGPLGQGIAQGVGLAIAEAQLAATYNRPGYNIIDHWTYVFCGDGCLMEGIGQEALSLAGHLGLEKLVVVYDSNRISIDGSTDIAFTEDAAKKYEALGFHVIPVSNGDSDFTALRAAFAECKQIKGRPKLVIVNTTIGYGCRLAGSEKAHGAPLGDDEVARVKEQFGLDPTKKFHVQPEVYGIFGKNAERGASRHEEWRVRMRKYTEE...
51
B7QC80
4.1.1.17
ACT_SITE 341; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MKSYPTCDVVNPMGAIGMVDSITSDPDNDQPFFVVDVADIVYKIKLWKLKIPRVEPFYAVKCNSDAAVLELMAGLGLGFDCASKAEIDVVRSLGVSPSRIIYANPCKTKSFIKHAAAQGVDLMTFDNEQELYKVKELFPLARLVIRIRVDDSGSVCQLGLKFGCEVSDAQHLLTIAKSLGLSVVGVSFHVGSNSREPMSFARAIESARLVFDQGLAMGFPMELLDIGGGYPGDRGFQKLFDKITQTINGSLALHFPEETGVRVISEPGRFFVASAFTLYTTVIAKREVLLPGSALPRAMYYLNDGVYGSFNCTVFDHAEP...
195
P0A8I5
2.1.1.33
ACT_SITE 144; /evidence="ECO:0000250|UniProtKB:Q12009"
MKNDVISPEFDENGRPLRRIRSFVRRQGRLTKGQEHALENYWPVMGVEFSEDMLDFPALFGREAPVTLEIGFGMGASLVAMAKDRPEQDFLGIEVHSPGVGACLASAHEEGLSNLRVMCHDAVEVLHKMIPDNSLRMVQLFFPDPWHKARHNKRRIVQVPFAELVKSKLQLGGVFHMATDWEPYAEHMLEVMSSIDGYKNLSESNDYVPRPASRPVTKFEQRGHRLGHGVWDLMFERVK
45
A0A8J0V176
1.11.1.6
ACT_SITE 57; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 130; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MAQQTHPILTTGAGIPTGDKLNVLTAGPRGPMLMQDVVFTEEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYCRAKVFEKVGKRTDVAVRFSTVAGEAGSADTIRDPRGFAVKFYTEEGIWDLVGNSTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDTVWDFWSLRPETLHQVTFLFSDRGIPDGHRHMNGYGSHTFKLVDTEGKAVYCKFHYKTDQGIKNLSVEEADRLVVSDPDYGIRDLFQAIAKKNFPSWTMYIQVMTFKEAEKCPFNPFDLTKVWSHRDYPLIPVGKLVLNRNPENYFAEVEQVAFDPSN...
13
B3SEJ4
1.8.1.4
ACT_SITE 447; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MQNFDYDVAILGSGPGGYVAAIKASQLGLKTAVIEKENLGGVCLNWGCIPTKALLRTAEILHYIKNAKEFGIKCEGFKVDFDKVIKRSRDVANKLSNGISHLLNKNKISIIEGYGRFLNKNCIEVTKGNNSTKVTAKNIIIATGAKPKFLKGLSPSDSKIIMGYREALLPKKLPKKILVIGSGAIGVEFASFYNALGSKVTILEIADRILINEDSEISEFAQKAFEKESIQILTSAKINKFSIKKDVINFEISSKDKNYNDSFDAVISAVGVSANIEDIGLEKINVKISDKKYILTDKSLRINENNIYAIGDVISPPWLA...
36
A0A0A0K856
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MEKGYFWWSIFGLIAIIGAIKGDDEGLSVGFYSKTCPSAERIVRNSVAKAVVNDPGQAAGIIRLYFHDCIVGGCDGSILLDSIPGITSSFDIERHSPGNPVLRGFEIIDDAKSKLESRCPQTVSCSDILAFAARDSVLVTGGFSYAVPAGRRDGRVSNGSAVFTNVPPITPNIARLKQHFESRGLSLKDMVALSGAHSIGITPCGAFSSRLYFFNETVETDPSLDPKFAAFLKTQCPKGKIGGTADLDNVTPNLLDVQFYENLRRKMGVLSSDQAMEDDPLTAATVREYRSSRSLWKADFTAAMVKLGNMKVLTGRQGEI...
14
A0A1D8PL41
2.3.2.26
ACT_SITE 940; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MFNFSGSTKKRVVNLGNKKSGYNNKINFLEQSRLQRQEREYQKNKEKSAIIIQNHIRKYLDLKKNCFAIINDWLNFPINNEQDFNSWINQFINLSKWYLLKQDDDLIYQVIKSLVEQLSDSMFEIYNTDGVILALNKLLSGLKDINILDLIVQALHIVISKTTNLGEVHGMINNLVKVFNNYELSPKQREVVIDLIFMINIHDSYHDFIKVLTLDYFDSENKKYLHVLRNTIGPTTRILQFDDEELISMLSTYLVIHGSEQFTQSDFLFIGSVLENIHCRLKLKDDDDEEEEFDAKDYEDDSKLNSNSASNTTTVYINDK...
65
Q8ZVF2
6.2.1.5
ACT_SITE 250; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01988, ECO:0000256|PIRSR:PIRSR001553-1"
MTVLVGPNTKVVVQGATGREGSFHLQRMLEYGTKVVAGVTPGKGGTTVHGVPVYDTVEEAVRRHGANASVIFVPARFAADALLEAVDAGVELSVVITEHIPVHETLRAVNYARARGVTVIGPNCPGIVAPPVRTKLGIMPNNIYQTPGKIAVVSRSGTLTYEISYQLVRAGFGINVAIGVGGDPIVGLDLMEATLKVAEDPEVDGVVVIGEVGGDAEERLARLYAEGVIKKPVVAYVAGRTAPPGKRMGHAGAIVMLGSGDATSKIEAFRAAGVPVAETPFEVPQLLAKLLKK
247
Q9XTT8
3.1.3.16
ACT_SITE 125; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P36873"
MLEEDAAGPDQLGPNDLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENIDSDPVFEVFEAATVENRGEPKKQPIAQYF...
144
Q8ZEJ1
2.7.1.21
ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124"
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRFGVGTVSSRIGLSSQAQLYNSGTSLLSIIAAEHQDTPIHCILLDECQFLTKEQVQELCQVVDELHLPVLCYGLRTDFLGELFPGSKYLLAWADKLVELKTICHCGRKANMVLRLDEQGRAVHNGEQVVIGGNESYVSVCRRHYKEAIKAACCS
88
Q9S219
2.7.1.23
ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361"
MTQNRVRTVFLLAHTGRPAAIRSAELVVKGLLRAGIGVRVLEAEARDLPLPGEVELVGEATPQCLDGCELLIVLGGDGTLLRGAEFARASGVPMLGVNLGRVGFLAEAERDDLDKVVDRVVNRAYEVEERMTVDVVVHRNGDIVHTDWALNEAAVQKAGAEKLLEVVLEIDGRPVTGFGCDGIVLSTPTGSTAYAFSAGGPVVWPEVEALLMVPISAHALFAKPLVTSPDSVLAVEVLPHVPPGVLWCDGRRTVELPPGARVEVRRGAVPVRLARLHHASFTDRLVAKFALPVSGWRGAPH
89
B9RUP1
5.1.3.3
ACT_SITE 191; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MGKISFLFCFCILVAFGFANGAEEKVEFYELKKGNISMKLTNWGASIVSFVIPDKTGKPIDVVLGYDTIKEYQTDSTYFGAVVGRVANRIGGAEFKLNGKTYKLPANDGKNMLHGGAKGYSDVVWKVTKYKNSGNAPFIVFTHRSSDGEEGFPGALRVVVTYTLLADGQLSVFMKAKGLDDKVSPVSLAQHTYWNLAGHNSGNILEAKVRIFGQFYTAVDENLVPTGQLLYARGTAYDFTEPELKPVGKRIDLLPKGYDINYVLDDFEPNKIRQVAIVEDVKSGVRMELATDAPGLQFYTGNMISNVKGKGGVVYQAHAG...
211
A0A0P0WHP0
1.11.1.7
ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MITILHVYACMISCSQIIINHYMLKNSQIISIYTCTHQRWSSSIPPSIDLSHSDLLLDWLHTSSSSSSSEMVKLVCFVVVVFMAAAAAMAGADRELKVGYYEKTCKDVEKIVNSIVVNSIKDNRGKGAGLVRLLFHDCFVRGCDASVLLEKSEMNRQPEKESPANIGIRGMDVIDAIKAVLEARCPNTVSCADIIAYAARDASRYLSHGGVDFPVPAGRLDGVVSRSRDADAFLPDAAANLTDLVRNFRRKNFTVEELVILSGAHSIGVTHCTSFAGRLTAPDAQINPGYRSLLVSKCGGVSPTPANNHVVVNNVRDEDG...
14
Q93Z96
1.3.3.3
ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000250"
MASHSSTLFTSPSSFILFSSHRLKSSPNYFTYHFPRSVKRPHFDLRCSVSIEKEVPETERPFTFLRVSDGDQTQSSSYSVRARFEKMIRTAQDKVCEAIEAVEEGPKFKEDVWSRPGGGGGISRILQDGNVWEKAGVNVSVIYGVMPPEAYRAAKAATSEQKPGPIPFFAAGTSSVLHPQNPFAPTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSV
27
H9GC08
2.5.1.18
ACT_SITE 38; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1"
MALLARAPRPLLFGWATASRTMATSPKKAVDFFYDVLSPYSWLGFEILCRYRNIWNIDLRLRPVFLGGIMKESGNKAPALLPRRGVYMNNDIMRMAKFCQVPLQLPKDFMGTVIEKGSLSAMRFITAVDLTQPQFVEAVSRELWMRIWSRDEDITQPENILTAAGKAGLSSDQCKKLLEMGSSPEVKNRLKATTDEVLKYGAFGLPCSVIHVNDKPQLLFGSDRLELLGNLLGEKWLGPVPTASKL
77
A0A1U7ZWI8
3.4.19.12
ACT_SITE 17; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 129; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 144; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MEEKPQIYHEKQKLQFCLLHALNNLFQEKDSFTREDLNLIAEKLVLDDPSKESWSPLSVIFKPHHNAITGNYDVNVLIAALEGKGKELVWHDRRNGASSIDLDRSEDALMGIVLNVPVKRFGGFWRSRHWVALRNIGGIWFNLDSDLVSPHPFEDSEEVKLFLDHIISEGGEVLLVLNRKQ
175
H3HD98
2.3.1.181
ACT_SITE 234; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1"
MSLRRSVLAATRPQRCVATAVKSLRFLSTQEAALETPQPQRKCVAYRLGRVDYETAWDWQKQLIQQRVLAMRAGEPVEKDVVLILEHPSVYTLGRGGTMENIKFDPEKEHVKLVRVDRGGEVTYHGPGQVVVYPILDLTQHKKDLHWYLRQVEEVVIRTLAKFRIEGERVDGLTGVWVEEKPGSGDEEHCKGHYEREMRKICAVGTHASRWVTMHGFALNVKTDLRGFDRIIPCGIDDRAVTSIERIRPDATIKDVQDAAIEAISEVFHLEMEDVEAKTPV
55
Q9T0I1
2.1.1.37
ACT_SITE 1085; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018"
MKTKAGKQKKRSVDSDDDVSRERRPKRATSGTNFKEKSLRFSEKYETVEAKKEQIVGDDEKEEKGVRFQSFGRVENWTISGYEDGSPVIWISTVIADYDCRKPSKKYKKLYDYFFEKACACVEVCKNLSTNPDTSLKELLAAVVRSMNGRKIFSSGGVIQEFVISQGEFIYNQLAGLDETSKNHETKFVDNRVLVSLRDESRKIHKAFSNVALRIDESKVLTSDQLMDGGEDEDLKYAKLLQEEEHMKSMDRSRNKRSSTTSAPNKFYIKINEDEIAHDYPLPSYYKNTKDETDELVLFNAGYAVDARNLPCRTLHNWAL...
47
Q4WQB9
2.1.1.33
ACT_SITE 232; /evidence="ECO:0000255|HAMAP-Rule:MF_03055"
MTPPPPKRQKRDEYRKATAEATSQSGASDVAEIKLPKKKYYRQRAHANPFSDHHLKYPLSPAHMDWSSHYPAFVNPDPSHINLAGARRLLKDVEVVDIGCGFGGLLIGLAPLLPESLIVGMEIRVSVLEYVTTRIQALRAQQQKLRAATATATAASETPSQQQAQIDGKQANANAAADAASPAPSTDTEHMPTTLVPGSYENISAIRSNTMKFFPNFFARHQLSKIFICFPDPHFKARKHKARIISETLNAEYAYALRPGGLLYTITDVEEYHHWILRHFGVELGAEEESEEKSTSPNANANAGVRELFERVSEEELEKD...
45
A2QQ28
2.3.2.26
ACT_SITE 789; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00104"
MGSNLPAQPNLRVTIIAADGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEMFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLQMGGDEMLTRDLKKSNDNLVVHGKLIINLSTNLSTPIPNQANGLHRSHAQSSTSSGLVPQVSSASHPSVSPGQAEPSAAASNVSLHPQRVPSTTRPTSTVGPVNGGPAPPPNGPQGSRTNLSSFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTTWTRPSSNYNEQTQRTQREANMQLERRAHQSRMLPEDRTGANSPNLQESPQPQPQQAHTPPAG...
65
Q00804
7.2.2.10
ACT_SITE 475; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q5ZWR1"
MGDMANNSVVYGGVKNSLKEANHDGDFGITLAAVRALMELRSTDALRKILESYGDVYGICTKLKTSPNEGLRGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVSDITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENR...
258
A7YWG4
3.4.19.9
ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"
MARLGRLLSVLGLVLCGATGLGLSAPPAPTPKKPIIGILMQKCHNKNMRALGKYYIAASYVKFLESAGARVVPVRLDLKNEEYEKLFKSINGVLFPGGSVNLMRSGYARVAKMFYNLSIKSFGEGDYFPVWGTCLGFEELIYLVSGESLLTLTDTVGIKLPLNFSRGTLQSRMFQNFPADLLLSLAVEPLTAHFHKWSLSVMNFTKNEKLKAFFSILTTNTDGNIDFISTMEGYRYPIYGVQWHPEKAPYEWGQLRGISHAPNAVKAAFYLAEFFVAEARKSNHHFESDVEETKALIYQYRPTYTGNVSSFQQSYIFD
176
P0ABF6
3.5.4.5
ACT_SITE 104; /note="Proton donor"; /evidence="ECO:0000305|PubMed:8289286, ECO:0000305|PubMed:8634261, ECO:0000305|PubMed:9125497"
MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA
187
H2MWH4
2.7.10.1
ACT_SITE 1152; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
MLNEGSTNPVKMKRLPAQTVFLIFCTCIVCHCGLINGEICSSIHIRNDVTNFQLLENCTVIEGHLKILLMFQTRSEDFRGLSFPKLQVVTDYVLLFRVYGLETLSDLFPNLTVIRGNNLFFNYGLVIFEMRDLKEMGLYSLMNITRGSVRIEENSDLCYLSTLDWSKILDSVEDNFIVGNKDERECGDLCPGTAEGRTICPQTTINGQYKARCWSQKHCQRTCLDKCKHGACNSRGQCCHDQCLGSCREPGNASSCVACRNLQHGNTCVDKCPPGYFVFRGWRCVSFSFCQELHDQCSLTKKQNQDREASCVEYVIHEGA...
97
B7P681
1.3.5.1
ACT_SITE 290; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
MTKAYNIIHHKFDVVVVGAGGAGLRSAFGMAKEGLNTACITKLFPTRSHTVAAQGGISAALGNMGEDDWRWHMYDTVKGSDWLGDQDAIEYMCKNAPDAILELEHCGVPFSRTEEGKIYQRPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLKHKVQFFVEYFAIDLLMEDGECRGVVAWNLDDGSLYCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDMEFVQFHPTGIYSAGCLITEGARGEGGYLVNANGERFMERYAPAAKDLASRDVVSRAMTIEIREGRGVGKHKDHVFLHLNH...
28
C4LSX4
3.4.25.1
ACT_SITE 26; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1"
MNMTNDPLPIATSYVNDKTKFLKTGTTICGLVCDKGQTVVLACDSRATVGPIVADKACMKLHKLAPNIYCGGAGTAADLTHATNFIATKLGVHRFTIGQMPRVDTAVTMLKRHLFPYGGHIGAYLVVGGYDYTGAHLWGVYADGSTSQHNYYSLGSGSIAATTMLDDQWNENLTREEGVKLATQAILAGIFNDMGSGGRVNVCVIDKNGVEEKLNIEHPNDRKFKNPDFKGFPKKLEILKKTVIPIEHEEEDFKDQKQMELE
180
A7SML1
2.3.2.26
ACT_SITE 1552; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MHQLLHRASNSGSNSKAQQLLQGIQSSDESQQLQAVIEMCQLLVMGNEESLAGFPVKQVVPALINLLNKEQKFELVNHACRALTYVMESLPRSTVVVVEAVPVFLEKLQVIECMDVAEQSLTALETLSKRHSKSILQAGGLASCLLFLDFFSISAQRSALAIASNCCSSVGPDDFHYIEDAIQDKKSVESCCLAFSRLVDSFQHDKAHLEDLAGHGLLTNIQQLLMISPPLISTATFVMVLRMLASLCANCPKLAVQMIKNNIADTLKFLLVGTLDIINNENVELIARSPQEFYEITCFISELFPQLPKTGVFSVDALLN...
65
H9GX67
3.1.3.1
ACT_SITE 108; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MFAVRVSVVCFLLTITSGSVEEENPEFWRKSAQNTLRSALSRKINTNVAKNIVLFLGDGMGVTTITAARILKGQLQKHSGEETVMNMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSAAARNGVCRSQKGNEVTSILRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADLPASAATEGCVDIATQLLHNIDIDVIIGGGRKYMTPKGFPDPEYPSDASAQGQRRDGRNLIQDWIQMKEGKVARYVWNKTDFDAVDPEKTDYLMALFEPADLRFDVERDHSMDPSISETTDKAIQILKKNP...
141
A0A1B6PT89
5.3.1.8
ACT_SITE 328; /evidence="ECO:0000256|PIRSR:PIRSR001480-1"
MASSTASLGPAAALLLERLGLRVAPTDAADDQAPPMPALPLPGLLPLRCAVQHYEWGRRGADSLVARLAGEASASDGGGDGRPCAELWMGTHPAAPSSLAPDVSLRDWVARNPAALGRAVAARWGGDLPFLFKVLSVAKALSIQAHPDRDLAAALHALRPATYRDANHKPEMAVAVTEFHALCGFAATQELKEVLRTVPEVQELVGKEESRKLLSVKEQDGGIGVRSYLKSAFTKLMTASDEAISEAIANLKTRLNSESKARSLTKKEQLVLSLEKQYPGDVGVLAAFFLNFVKLNPGEALYVGANEPHAYLSGECIECM...
214
Q89CN8
4.1.1.17
ACT_SITE 328; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MTERIQEFLRNRRSEGRDTEPCLVVDLEVVRDNYQTFSKALPDSRVFYAVKANPAPEVLALLASMGSCFDTATVAEIEMALAAGATPDRISFGNTIKKERDIARAFALGIRLFAVDCAAEVEKIARAAPGAKVFCRILYDCAGAEWPLSRKFGCDPEMAVDVLDVAKRLGLEPCGISFHVGSQQRKVKAWDRALAMASQVFRDCAERGINLSMVNMGGGFPTKYLKDVPPVVTYGRSIFRALRKHFGNQIPETIIEPGRGMVGNAGIIESEVVLISKKSDEDEVRWVYLDIGKFGGLAETMDESIRYAIRTAHDGADMTP...
195
Q54MY9
2.7.11.1
ACT_SITE 706; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDNNSTLNNITITVASSHNNTTTNSNNNNNNNNGSNSNNNNEQLNTLSNSITSLKSLNISGSGVITNNSEVNTPSEGNITPLPLLSLSDALSPLRELYSCLYVGDIRALMSNQYLKFEENEKIRILGFPEPHLEIDEKTQKYFSYQIIEFESDEDILSIAKSFEQYSQLILGRTPTQPVVIQECCFGLVLASIYFIKYELFSLPQAHDLIGYNDFFGTSKKHSHFEKVDSCTLINDITSYYYNNMSSKRKTTIFSNNISFTNLQTTTPPTTTTTTTTTTTTSSSNNSEQIESTSKNNSSGITSPTSIKPKNKVGLLKKLF...
99
M4DL50
4.2.1.11
ACT_SITE 247; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 384; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MATITVVKARQIFDSRGNPTVEVDVHTSNGVKVTAAVPSGASTGIYEALELRDCGSDYLGKGVSKAVGNVNNIIGPALIGKDPTQQTAIDNFMVHELDGTQNEWGWCKQKLGANAILAVSLAVCKAGAVVSGIPLYKHIANLAGNPKIVLPVPAFNVINGGSHAGNKLAMQACSLWFLFVDMLNFKLLQVLKISDCDWLLCLQEFMILPIGASSFKEAMKMGVEVYHNLKSVIKKKYGQDATNVGDEGGFAPNIQENKEGLELLKTAIEKAGYTGKVVIGMDVAASEFYSSDKTYDLNFKEENNNGSQKISGDALKDLYK...
200
H2XPZ0
3.5.4.5
ACT_SITE 58; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MSKNSPKELLEMAREAKKFAYNPYSKFRVGAALVTKEGRIFTGCNVENVGFTSTICAERTAICKAISEGYRDFVEIAVTSDLEDEIVTPCGVCRQTLSEFGSNIKVYCSKSDLGFEEFTLKELLPRAFENNHLESFQATIKNTSPFSIWQQKKTT
187
A0A2R6WSG7
2.3.2.26
ACT_SITE 1947; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
METRSRKRAEATSHRPSPATPSRSKRARVSANNSNSSASASFAPPRSRPSTRAAPATPVIVPTTSGSAMDSGLDSSASGSKRAHDKGAKKEPEKEEDRLAEKEREKEIKERELEKGKEKEPDKEKDTRSSRDRDRTPAAASGGADDDHDGEGGSSLHQNLASASSALHGLLRKLGAGLDDLLPSSTPSSHQNSRLKRILSGLRAEGEEGRQLDSLSQLCELLSIGTEESLSSFSVDSFVPVLVGLLNYEYNPDMMLLAARALTHLCDVLPSSCAAVVHYGAVPCFCARLLTIEYIDLAEQSLQALEKISHEHPTACLRAG...
65
Q8EIB3
2.2.1.1
ACT_SITE 412; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MSSRKVLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPKWVDRDRFILSNGHGSMLIYSLLHLTGYDLPMDELKQFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNREGHEIVDHYTYCFLGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKAVTDKPTMICCKTIIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWPHAPFEIPADVYAGWDAKDAGAAREAAWNDKFAAYAAAYPE...
51
A0A1S4DPR2
3.1.1.11
ACT_SITE 175; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MEGKEMGIFRIILVMFWWGAGNCMTFSSTVAEDGTGNFTTITDAVNAAPSQSATLFFIHVKAGTYNENVVVPNYKTNICLVGDGMGITIISSNKSGSSVAGTATLGVYGKGFIGMKMTIRNTAGAGAGQSAALTSAAFHGFASYYQCRFESFQDTIFAQVGAQFFRECEVYGTIDFISGDGQAIFQNSVVYARTPVPGQEVTIIAAGLDNITTNPGLILQNCTITPAPDFNKSAVKSYLGRPWKNLGRGVVMSSFIDGFIDPQGWLQKPDVANTYFAEYNNRGPGSNTTGRLNWSKVIDKTEASKFTVRNFLQGDKWIPD...
125
B4FRD6
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKKSSMMAPMTIMARVAAVLVLSSAAMASAAGAAGLDMNFYGSTCPRVEAIVKEEMVAILKAAPTLAGPLLRLHFHDCFVRGCDASVLLDSTPTSTAEKDATPNLTLRGFGSVQRVKDRLEEACPGTVSCADVLALMARDAVVLANGPSWPVALGRRDGRVSLANETNQLPPPTANFTRLVSMFAAKGLSVRDLVVLSGGHTLGTAHCNLFSDRLYNFTGANSLADVDPALDAAYLARLRSRCRSLADNTTLNEMDPGSFLSFDSSYYSLVARRRGLFHSDAALLTDPATRAYVQRQATGLFTAEFFRDFADSMVKMSTI...
14
Q6ED60
3.1.3.48
ACT_SITE 837; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1"; ACT_SITE 1153; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1"
MTMYLWLKLLAFGFAFLDTEVFVAGENPTSPTTGPTATKKSSVPLSGDPLPTHTTAFSPASISERENGFLETTPSLSPASTSTQVSLDSLDNASAFKTTGVPSEQPPHLPTQADSQTPSAGTDTQALSGLAAHATLSPAPGSNDASDVPGERSTASPFPTDPVFPLGTTPIPARNSSAALPARTANTTITASSPDSHALETITLSPSGSTAHSTKIVATTPAKPSCDEKYANITKLFTAKLNVNEVVKCAEFDCTNNMLHNLKECEIRTVTISDNSCTAPNKTLILDVPPEVDKFHLKDHTSPEKANTTINLKWENTENF...
149
H3GYJ5
2.3.2.26
ACT_SITE 1810; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
RDDDEFLNAALDELVEEGALARELARSGFFGGELDTEEAPAAPAPPRRGVSARTGRGGGRSNAARMLEALEALSHDAEGGAGVPQSLRGLLEQLHGGDGGMFPLSQLLQRNPRFQRMLEQVGADQPVHTQMAGLSELCETLSLSTEEALAVSGFSVDSFVPAVVTLIRAPSSMDVLLLAARALSTILELYPSTGIQKATAEHVIPSLCEKLLEIEYMDVAELALQILEKIVCKAEPALASTVTSVAQLCAQYRMEVIQENGIVALLQFVDFFPLEIQRRAARIVCQLCTDFPLSMEGKMRQGLPYITNLLRSFDNEILQS...
65
Q5JMS4
1.11.1.7
ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASRRSAAASPAMAAAAAVVAVSVYLLVCSAPAAATAAAVAKKPSYPPVAKGLSFDHYKKSCPQAEAIVFSFLRDAIGKDVGLAAALIRLHFHDCFVQGCDASILLTKTPGGPDGEQQAIPNESLRPAAFKAVNDIRALLDRACGRVVSCSDIVTLAARDSVKLAGGPSYKVPLGRRDGLTSATPSQVLGALPPPTSHVPELIAALAKLNLDAADLIALSGAHTVGIAHCTSFTGRLYPKQDGTMDKWFAGQLKLTCPKNDTANTTVNDIRTPNAFDNKYYVDLQNRQGLFTSDQDLFVNATTRPLVAEFAVDQSAFFHQ...
14
Q9HSB9
4.2.1.20
ACT_SITE 46; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 57; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"
MTRSDLAAAFDDGPALVSYVVAGDPTPAATAEYIDALVDGGTDVIELGLPFSEPVAEGTTIQNAIKRALDAGMTPDAYLDLVARIDADVPVVCMTYYNLLFQYGDRAGPAAFVSAAAEAGVSGFVVPDLPVDESGPLREACRAHGLDLVFVVAPTTTADRRERMLDLTTGFVYVQGRVGTTGAREEVSAATPDALAALQHTDIPKAVGFGVSSGEQAREITASGADGVIVGSAYVDTVADGVADDDPPSVVADRLRDLAAELKAGAARGVPEPEHK
202
B5YH90
3.2.1.21
ACT_SITE 327; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
MRNKDFLWGVATSAFQLEGSPYADWSTWDSIFSLNPKITNHYELYREDIRLIKNLGVNSYRFSIEWSRIQPSEDYWNKEVVRHYQKIINLLNENNIKPMITIHHFTHPVWFITKYPWHKKKSIDKFMEYVERLIENINNVDYWLTFNEPYLLILGGYIEGCIPPGYQNLNLALKAMKNIFICHRQIYDLLHLKNKNSMVSIAHNMAVFAPWIKCNPFDRLLAKIAKRFYNHSIIEGFMDGKISLPIPFRKTMEIEVPIKGKLDFFGINYYTRVHMRFNPLRKLFIEFRHRDIDGHGLTDMGWEIYPKGLKKVLKYASKLN...
161
A0A1Y1I9Y1
2.7.11.1
ACT_SITE 254; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MPPATPLHAAHAQVAAHDAAHAPRLQQQRDHATEEVLLRTSEALGQPQRMTPPATGRIQKARNEFLVSEKTGRAVLAENDENRPNMDASVSGMDEEQLDPKQALRGKESTSCEVGSLQKGKDEKRWQLGDFDIGKPLGRGKFGNVYLAREKASKYIVALKVLFKNQLQQSQVEHQLRREIEIQSHLRHPNILRLYGYFYDTNRVYLILEYAAKGELYKELQRCKYFSERRSATYIASLARALLYCHSKHVIHRDIKPENLLMGIKGELKIADFGWSVHAPNSRRQTLCGTLDYLPPEMVEGREHDATVDVWSLGVLLFEF...
99
A0A0K9P323
1.11.1.7
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKNIGVVVVLFALAVVHGDHLEVGFYEGSCPSAEALVQQVVAEDFLVDPGVAPGLIRLHFHDCFVRGCDASVLLNVSDDGSTEVERKAGPNLSLRGFKTINKAKAAVELNCPGVVSCSDILAFAARDSSSLSSAGSISWDVPAGRRDGRISILSEAQSGNLPPPFFNASSLVTNFEQKNLTAEDMVILSGAHSLGVAHCQAFTSRLYEDPNLPDSPPQTASGLSLAYADLLRKLCPSDPPVDLSAFMDVITPNTLDNKYYFGVLNNLGLLNSDNALREAVDLKAIVEKMSKYPVWWGKKFGVSMVKMGGIENTEEVVTEI...
14
B9S678
3.2.2.27
ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072"
MASAAKTLRDFFQPAAKRLKVVSVSSSDPPRTLNLCTDSIGDSSSEQRSRIQFNKHRAKSKRNLNHCLQLVSNSKSYVKLEELLVEETWVEALPGELQKPYAKTLCKFIEKEISCESEPIYPPQHLIFNALNSTPFDRIKAVIIGQDPYHGPGQAMGLSFSVPEDVKVPSSLVNIFKELKQDLGCSIPSHGNLQKWALQGVLLLNTVLTVRNHQANSHAKKGWEQFTDSVIRLISQRKEGVVFLLWGNSAQEKSKLIDETRHYILKAAHPSGLSANRGFFGCRERGKISCMSHSYGKLNFRNFDAIQWKLAFMRSELSSK...
173
F6PFU8
2.3.2.26
ACT_SITE 889; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MRSGAPTSSGSGDQWGRSRESGVAGEGGSREGSSAVPLRLLQFFGDDMASASSGRAGAGLPFEKSQLTLKVVSAKPKVHSRQPRINSFVEVAVDGLPSETKKTGKRIGSSELLWNEIINLNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGLTVDLGSVPNGSAVTDGSQTPGRELSGTTPSPESRQQGSSTNCFGSRSRSHRHSVGAARATPANGEQSPGTRSRHRQPVKNQSHSGTASGTVNGEPASTSAIDPEEGPVVGVTPPPAAVSNGTPDVNSAP...
65
A0A3Q2UKD3
2.7.10.1
ACT_SITE 968; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MDPLAPLVLYGFSLIISGKVEAALDLILINSFPLVGNSETSLICITSKWRSRESITIDRDQEDVTNQHREPLEVSEDSKRATAKMVIWKREKASETIGAYYCEGKLKDEVTRIHTMKMPRGASFHPVALTVTANKGEHVNISFIRMAAKEEDAVIYKNGSFIHSVPRHEVPGELEVSYPHVQLQDAGVYSARYIGGNLFTSAYTRLIVRRCEAQKWGPSCSSHCPSCMNNGICHEDTGECICPPGFMGKTCEKACGANTFGKTCEESCKENYGCKNYMFCLPDPYGCSCATGWMGLECDKECKPGYYGSDCKLKCNCHNR...
97
Q7XUN6
2.7.11.1
ACT_SITE 477; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MVLPKPEMPFFVLLLFLGLGCLRPAAATDERFVFNGFTGANLSFDGMATVTSNGLLMLTNGTNQLKGHAFFPSPLQFQRGPNSTAMQSFSTAFVIGIIGAFEDLSSHGMAFIIAKSKNLTSALPGQFMGLVNSANNGNATNHLFAVEFDTILNSEFNDMSGNHVGIDVNGLNSVDADNAGYYDDGTGDFKNMSLVSRRPMQVWVDFDGQTMQVNVTMAPLEVARPKKPLLSKIVNISSVIDDTAYVGFSSATGILFCRHYVLGWSFKMNGAAPALNISSLPSLPVTFPKPRSKTLEIVLPIASAVLVFAVAAAVFVFMRR...
99
B8C8Z3
2.3.1.286
ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSASYAERLSEYPNKGVCGLPESYDTPRSFTSKLDALTKLVKRSRHTVVLTGAGISTGAGIPDFRGPSGIWTKEQERKKREKRALSKKKIFTSFASAIPTYTHRTLTSSNNNKFLHHIVTQNIDGLHRKTHLPRQHQSILHGCIFTEICDTCHTEHVRSYEIDSIGLKYTGNVCTLGGSSGSGSCKGKLKDTLLDWEDALPDVDWTRAQEECEKADLIVCLGTSLRIEPAGSLCGGSGGGGGRSSKLGYAIVNLQQTPYDDGAALVIRAKVDDVMRGLMA
58
B3RVX8
2.3.2.26
ACT_SITE 549; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MLIPNFISVCALNLLCIITVERWEERTDPYGRHYYVDHNTRTTTWERPEPLPSGWERRHDQYNRPYYVDHNTRTTTWHRPTSESIRTFQQWQERRQQNQDVRRQNYQQRYLIPSSGIQVVGRDLPPGWERRIDHNGRVYFVDHNTKTTQWEDPRTLAPLPPSWEKKVTDQGIVYFIDHSTKTTTYTDPRTGAPRYLKCFSSYQGNFDWRLAGFRQMCQDSALPGHTKIAISRNTIFEDSYNAIISLKPYDLRKRLYIMFKGEDGLDYGGLAREWFFQLSHEMLNPMYCLFEYANQNNYSLQINAASSVNPDHLKYFKFVG...
65