Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A2GWL8 | 1.1.1.8 | ACT_SITE 202; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MSYKLSIIGSGNFGSCIARHCAANIKNVPSMDQHIKMWVLEEVVNGESLIHTINTTHENIKYLPGYNLGENVEAIGDVVECCDADFFIFVVPHQFLPATLEKMKGHVKKTATGCLLTKGINFKDGKIQLLTDTVEEILGIKCGSLMGANIANEIARGDFCESTLAFPDIPERDTWKQLFDSPKFKISCTNDIVTQQLSGTMKNIIAIGGGIVDGLNMGQSTKAAILREGFVEIYEFAKMMFPDRGVDILTMIESCGFGDIVASSYGGRNRKCAEYFVKSGKSFKECESELLNGQKLQGTLAAAEVYKILEERNATDKFPL... | 7 |
A0A022QGX3 | 3.1.1.11 | ACT_SITE 375; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGTPKYIVLWVLLAISTSNFSTICLAKKGSSTNFEENVRTQCGFTRYPTLCVQTLTGSGSLNPNVDFLSVLINKTMFETKIPSFSSNFQILSSHFVSPQAQQARFAMDYCDELMSMSMKRLNQAMEALQKPSPEKQKVDIQTYLSAVLTFQQTCKDSVEDHITSNVYMSEMYKKMDRLSELCSNTLALANRITGNIPAIRRNLLTGDGYNFPGWLSAGDRKLLQSTKIKANAVVAKDGSGDYKTVTEAIQAASGGRFVIYVKSGTYNEKINTNKDGITLIGDGKYSTVITASSSVGKGSTLRGSATFTITGDGFIARDIG... | 125 |
Q58989 | 3.1.3.3 | ACT_SITE 11; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:11342136, ECO:0000269|PubMed:11438683, ECO:0000269|PubMed:12051918"; ACT_SITE 13; /note="Proton donor"; /evidence="ECO:0000269|PubMed:11342136, ECO:0000269|PubMed:11438683, ECO:0000269|PubMed:12051918" | MEKKKKLILFDFDSTLVNNETIDEIAREAGVEEEVKKITKEAMEGKLNFEQSLRKRVSLLKDLPIEKVEKAIKRITPTEGAEETIKELKNRGYVVAVVSGGFDIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEGEVLKENAKGEILEKIAKIEGINLEDTVAVGDGANDISMFKKAGLKIAFCAKPILKEKADICIEKRDLREILKYIK | 147 |
Q8Y6R8 | 2.1.1.33 | ACT_SITE 118; /evidence="ECO:0000250" | MRVKHKPWAKDRLEEFPAIYIKNPEDFKGQWHEVFGNDNPIHIEIGSGKGQFISGMAKANPEINYIGIEMIESVLVSALDKAIEVDVPNLRLVARDAKLLEDCFEKGEIAQIYLNFSDPWPKKRHTKRRLTNPTFLTIYERLLPKAGEIHFKTDNRSLFEYSLVAFSEYNMLLTFVSLDLHNSDYEGNIKTEYEEKFSAKGFPIYRLEAKFDRN | 45 |
O69719 | 3.5.4.33 | ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MTTDEDLIRAALAVAATAGPRDVPVGAVVVGADGTELARAVNAREALGDPTAHAEILAMRLAAGVLGDGWRLEGTTLAVTVEPCTMCAGALVLARVARLVFGAWEPKTGAVGSLWDVVRDRRLNHRPEVRGGVLARECAAPLEAFFARQRLG | 186 |
Q8EXU6 | 2.7.1.11 | ACT_SITE 199; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01981" | METKIQNFGECSIPSPADYEYYTSDTSRLIFRTVFQSKEDWNSYVQEGPDFFEQAGPREKIYFNPQEVTAGIVTCGGLCPGINDVIRGIVMELYYRYGVSRILGFPYGYQGLVKRYSHQPIELTPEKVAHIVDEGGSMLSSSRGNQSPEEMVDSLSFYGVKILFCIGGDGTLRGARTIVDEIAKRKEKISVVGIPKTIDNDINYVQKTFGFSTAFSKAMEAVECAHVEAKGAPNGIGLVKLMGRHSGFIAVNAALASRNVNYCLIPEVDFDLFGNEAFLDDLKKRIQKKGHAVIIVAEGAGQKFFDSTEERDSSGNLKLK... | 84 |
A0A059AC04 | 3.2.2.27 | ACT_SITE 173; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MEMAPPKTLLDLFQRPSKRLRASSPSSPSSPSSSLPVAKSLSAAPDGGDGTTSSSSSSDLTPAQKSRIELNKLLAKSRRNLKICSDRISRSKAEGAGYVKLEELLVEETWLKALPGELQKPYAKNLCKFLQAEASSAAGDVKGHVIYPPQHLIFNALNSTSFDRVKAVILGQDPYHGPGQAMGLAFSVPEGIKLPSSLANIFKELKQDLGCSIPSHGNLERWSTQGVLLLNAVLTVRSHQANSHAKKGWEQFTDAVIKTISNEKKGVVFLLWGNSAQEKRRLIDETKHHILKAAHPSGLSANRGFFGCRHFSRTNQILEN... | 173 |
Q8P3S6 | 1.1.1.49 | ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MQRRGPARRRVRPAQQTHAWQLPARVFPRGPGQCGIAPAWTHGREGDASMSEQVTTPPCIIVVFGARGDLTRRLVMPALYNLRRAGALGEEFAIVGMDHGDITERAWRTNMGKAMTELLSSRDAEFQADGFDTDTWDWLRERMHYVRGDFTDLRAYQSLDGVLEKLHKRYGTRGNVLFYLATAARFFEPVLLNLGEAGLVKQREGAGWRRVIVEKPFGHDLPSAKHLNATVARVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEGRGRFYDPTGCLRDMVPNHLFQLLAMIAMEPP... | 6 |
O16580 | 3.2.1.45 | ACT_SITE 358; /note="Nucleophile"; /evidence="ECO:0000250" | MKSRFLLKIFIFLAVFGVDSVRAADCTEKTFKTGTVCVCSLDSCDEIPPLDITMGQAALYTTSHTGARLHRDVIYATDTEPFGTLHMTIDSSKKYQTIQGFGSTFSDASGANLKSLPDKLSDLIMKQYFSDTGLNLQFGRVPIASTDFSGRVYSYNDVANDYSMQNFNLTKEDFQWKIPYIKNAQKYNPNLKLFAAPWAAPGWLKTTKEMTGPGALNGKAGDNYHQAYAKYFVRFLEEYGKSGISFWGLSTQNQPTLGSDKKNKIQSTLFTAETQRDFIKTDLGPALAASSSGKDVKLLILDDNRGNLPKWADTVLNDMD... | 168 |
D6W990 | 3.2.1.143 | ACT_SITE 293; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 311; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 312; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MSDSESQTWLGTPLSDMYKGQGPWGFATAPVTPAKYHHVLFELPVTLKEPPEPHYNAQPKHWDDDYVRMPYSSHSLFLVKENGEEVIKPRWDVINEALSKPITSVEDLEKAINTYNNKLPKFTALKHFFNDVIEEEEAQLFFTSLLPKIIKLALRLPELVPGSIPLLRKNHSKSVSLSQLQVASLIANAFLCTLIWRKKTSDTFPGVNFTKLFNADDRTLRQECVAEKLKCIMHYFNRVTTKTPVGVITFERKFVPRSQMPRWDALDNNLGNTKVHISSSGTIEEARGFLQVDFANKFIGGGVLSYGCVQEEIRFVICPE... | 159 |
A0A2R6WMP3 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASTWILRTFGVLVVMACSVDAQLSTRFYNTRCPNVTARVGEIIRGHIRRDRTMAPALLRLHFHDCFVRGCDASVLLNNPSGGRGEKEATGNKFSIRGFEIIDDVKAKIEAMCPGVVSCADILALSARDAMRAFGGIDWAVPLGRRDGTITSAAEANRDLPPPFANFNTLSAIFRRKGLSVKDMVILSGAHTVGLTRCASMQTRLYNFSPTSPTDPSIDPAFAASLKRECKRGDNNTLIRNDPTKPTDTWDPNYYSNVLRSKSLFISDDAMKRSPEARKIVLTQNQPGSPFSKEFARAVEKMGRIGVLTGRQGQIRQRCS... | 14 |
B9HHE9 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAIQKLFAVCFLQLVFAFLLAGLTNAGGLQLGFYQRACPDAELIVHQTLYRYVSRDRTLAAPLLRMHFHDCFIRGCDGSVLLSSTEKNQAEKDAIPNKTLRGFNVIDAVKSALEKNCPGVVSCSDVLALVARDAVLMIGGPHWDVPTGRRDGRVSIANEALFNLPSPFANITVLKQQFAATGLSVKDLAVLSGGHTIGIGHCTIISNRLYNFTGKGDTDPSLDPRYAAQLKKKCKPGNSNTVVEMDPGSFKTFDEDYYNIVAKRRGLFRSDAALLDDAETRDYVKFQSRTQGSTFAQDFAESMVKMGYIGVLTGEQGEIR... | 14 |
H2XR98 | 2.7.11.1 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MPSKLSDYDILHLIGSGSYGKCLKVRRRSDSKILVWKDMDYGSMTEPEKQQLVSEVNLLRELKHRFIVRYHDRIIDRSKSRLYLIMEYCAGGDLASLITKCRRERNFLEEDFILKIFCQLLLALQACHGQRRRNGNQGKVLHRDLKPANVFLDENKDVKLGDFGLARVLNHDTSFAKTFVGTPYYMSPEQMNKMQYNDKSDIWSLGCLIYELCALVPPFTAPNQKMLAVKIKEGQFRRIPSKYSNELQDCVASMLNLTSTSRPSLEHILSLNILKKHAKEHDELNSSVNSQSPVVSTEEKHVSDIPDDRSSPSAILKARE... | 99 |
O83816 | 1.2.1.12 | ACT_SITE 162; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MRVAINGFGRIGRLVLQAMAEQKLLGKEFDVAAVVDLSTDARYFAYQLKYDSVQGKMGSSLSAPAEDILEVGGHRIKCVCGRGLKPSQLPWKDLGIEVVIEATGIYANESSYGHLEAGAKRVIISAPAKSSDASKPVKTIVMGVNEHEFDPAEHKVVSNASCTTNCLAPVVHVFLKEGVGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGEVLPSTRGKLTGMAFRVPTPTGSVVDLTFRTEKETSVADLNAMLKKASESYLRGVLQYCDEDIVSADVIHNQYSSIYDSRATLQNNLPNEK... | 22 |
Q980S6 | 6.3.4.2 | ACT_SITE 386; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 511; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 513; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MPNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEVFVTEDGAETDLDLGHYERFMDVNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVTDQIKDMIRYASKINNAEITLVEIGGTVGDIESLPFLEAVRQLKLEEGEDNVIFVHIALVEYLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKIALFTNVKVDHIVSSYDVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVGKYTKLKDSYISIKEAIYHAS... | 252 |
Q9T058 | 2.7.11.1 | ACT_SITE 662; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQICKKNVFLLYYGVLVFLSFQVSSSTDTISTNQPLSGFETIVSSGDIFELGLFTPTPDTYDHRNYYIGMWYRHVSPQTIVWVANRESPLGGDASTYLLKILDGNLILHDNISATRKSHTEGTSRRSPQKISEGNLLFHETVWSTGVNSSMSKDVQAVLFDSGNLVLRDGPNSSAAVLWQSFDHPSDTWLPGGKIRLGSQLFTSWESLIDPSPGRYSLEFDPKLHSLVTVWNRSKSYWSSGPLYDWLQSFKGFPELQGTKLSFTLNMDESYITFSVDPQSRYRLVMGVSGQFMLQVWHVDLQSWRVILSQPDNRCDVYNS... | 99 |
A0A2R6XB35 | 1.11.1.7 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAPTCRAGLTDAVVGLILPKSPPSPAYPPPSPAPTSPPPPAPAGLNPLYYASSCPSATAWVQNMTSNMVADDRTMAAAFLRLHFHDCFVRGCDASVLLDSTSGNTAEKDALANANSLRGFYQIDQIKAQLESVCPGVVSCADILALTARDAIVTIGGLSWVVYLGRKDGVVSTAAEAMASLPSPFSNYTELTQAFAKVGLGEKDFVVLSGGHTIGTAKCGILFSRLYTFTGPGAINGTDPTLNADLAALLKQQCPQNAPLNTVFMDPSGSFPGQTYDNGYFMQVKANKGVFTSDAALLTSSFAASLVAREASATSPFMK... | 14 |
P31482 | 3.1.1.4 | ACT_SITE 68; /evidence="ECO:0000250"; ACT_SITE 113; /evidence="ECO:0000250" | MKVLLLLAASIMAFGSIQVQGNIAQFGEMIRLKTGKRAELSYAFYGCHCGLGGKGSPKDATDRCCVTHDCCYKSLEKSGCGTKLLKYKYSHQGGQITCSANQNSCQKRLCQCDKAAAECFARNKKTYSLKYQFYPNMFCKGKKPKC | 130 |
K3Z7M2 | 3.4.25.1 | ACT_SITE 112; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MAPKKNLQNESPARYWRRRPPFFLLPQSNPNLSAGCCASTPIRIQKTKEKGNKKQKRGKELRRSPLSHRLQTQTIRMMDLPAKGGFSFDLCRRNDSLEKNGLKIPGFLKTGTTIVGLVFQDGVVLGADTRATEGPIVADKNCEKIHFMAPNIYCCGAGTAADTEAVTDMVSSQLQLHRYATGRESRVVTSLTLLKSHLFKYQGHVSAALVLGGVDCTGPHLHTVYPHGSTDTLPFATMGSGSLAAMSVFESKYKEGLTREEGIQLVCDAIRGGIFNDLGSGSNVDVCVITKGKTEYLRNHQLPNPRTYVSSKGYSFTKGQ... | 180 |
Q8ZDG9 | 2.3.1.181 | ACT_SITE 173; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013" | MMPRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTYHGPGQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDLEPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL | 55 |
F1A0D5 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTKLNIGDQAPEFTFPNQDGKDISLSQFEGKPIVLYFYPKDDSPVCTKEACEFRDKYQKFIEAGADVIGVSQDDTKSHYKFTSKYSLPFTLLSDKGGKLAKLYGVGKTAFILPGRTTFILDKNHKIALIHSSQFNSHSHIEESLKVIESLKNK | 12 |
D2A3C2 | 3.1.3.1 | ACT_SITE 127; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MFVAITVLCLLVPSQLAAVIKNENLFQYINPTPDNELLREDKQFWYDVGNNYLEKNLRYDHESTTKVAKNVVILIGDGMGISTITATRIYKGQRSGKSGEDHTLAYDNFPNVALVKTYNVDMQVPDSAGTATALFTGVKTRYEAVGVDVNCNKTIADRTVFEASKLEGIMTWAQQANKSTGIVTTTRITHATPASTYAHAHYREWECDSEMPQEFKPFVKDIARQLVEDAPGNNFKVILGGGYQQMGHIFEDLSDGECVRNDTLNLTQTWIDDHKGLKASFVTNNQQLENVGDVDYLLGLFYPDHLPYELLRNKGLDGTP... | 141 |
Q8EBR0 | 4.2.1.11 | ACT_SITE 209; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 341; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MAKIINVIGREIMDSRGNPTVEAEVHLEGGFIGMAAAPSGASTGSREALELRDGDKSRYLGKGVLTAVANVNGPIRTALIGKDATAQAELDQIMIDLDGTENKDKLGANAILAVSLAAAKAAAAFKGMPLYAHIAELNGTPGQYAMPVPMMNILNGGEHADNNVDIQEFMVQPVGAKNFREALRMGAEIFHTLKKVLHGKGLSTSVGDEGGFAPNLSSNADALAVIKEAVELAGYKLGTDVTLALDCAASEFYKDGKYDLAGEGKVFDSNGFSDFLKSLTEQYPIVSIEDGLDESDWDGWAYQTQIMGDKIQLVGDDLFV... | 200 |
A0A251UB30 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPGLTIGDSLPNLQVDTTHGKINLHDYVGDSFTIIFSHPGDFTPVCTTELGAMAAYADKFAQRGVKLLGLSCDDVQSHKEWIKDIEAYNKGKKVTYPIAADPNREIIKQLNMVDPDEKDASGQNLPSRALHIVGPDKKIKLSFLYPASTGRNMDEVVRALDSLIKASQHKIATPVNWKEGEPVVIAPSVSNDEARKMFPKGFQTVDLPSNKDYLRFTSV | 12 |
Q86IL4 | 3.1.3.48 | ACT_SITE 70; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 104; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MDPGRSHIETIIESSTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFEGVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKASKKAGCKIM | 149 |
A0A8V0Y5F1 | 3.4.19.12 | ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_03062"; ACT_SITE 753; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03062" | MGKKRTKGKTAQADESMDIVEPVCKHIRKGLEQSHLKKALLNVEWHVCQDCKADNKTQEKSEEETDESPSIWLCLKCGHRGCGRNSQEQHALKHYTTPRSDPHCLVLSLDNWSVWCYICDNEVPYSTSTRLGQTVDYIKKQVCVNSSHLVEKQQENKDVGNKKVEKDSRNEQQKEVLLKESSHSSTSSEVTVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEAKMPDTTVKIDSPELSMEPQLVKLDQPGPLTLAMHQFLTEMQETKRGVVTPKELFAQVCKKAIRFKGYQQQDSQELLRYLLDGMRAEEIQRISVGIL... | 175 |
F7F1W5 | 2.7.11.13 | ACT_SITE 475; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000550-1" | MAAEPAPGPTPAPPPPPPPAEGEENTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIHIKAQIDKEVLTVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFKFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGEEGNEELRQKFERAKIG... | 100 |
A0A1D6EIJ0 | 3.1.3.48 | ACT_SITE 132; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MPYLVRERLYFGGIKDAIAALTESSSTPDFTHVLSVVSSASISFITDCRPGLEIPTEEVLRVVAGEEGAAPTAAVPPGTLMRVVERAGHGLRVTRMAVPLRDTEEADLLDRLEPCLEFIDEGRKVGNVLVHCFAGVSRSASIIVAYLMRAEQKSLEEALEALKEISESACPNDGFLDQLKLFEEMGFKVDTSSPLYKRFRLKLLGQSYISGEKISSYMFEDDPGLSLESGSCQDSSKVEQRKTAYRCRKCRRVIAVEGNVISHVPGEGESCFDWNRRKSGHPYNNKEHGCSSLFVEPLKWMTPAVEDGALEGKLSCIHCG... | 149 |
A9UX39 | 5.1.3.15 | ACT_SITE 143; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 236; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MEAIRVSGLDGSAIAVHLNGATVTEWKNQRSDNAFFVSERSEWQEGRPIRGGIPLAFPQFAGDGPLPNHGLARTLPWTVAEQATGYIQLCLQESAASRELWPYAFDATYSVTFNASSFSSVLEITNPHARAAGSAMQFQALQHTYYQLDAVTTLQLSGLEGRTFLDKLTGKSPKQAPMTPLTIQAETDAIFVPSQNPRPVLLQLEGAPVIWNPWIAKSAAMADFGDEEYQHMVCIEPGCVSQPVTLEPGATFRLEQHITLLVC | 210 |
Q9W3C7 | 3.1.2.22 | ACT_SITE 123; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 241; /evidence="ECO:0000250"; ACT_SITE 295; /evidence="ECO:0000250" | MISICCSRFSCILFLLFLIFSLVLSYIWWSPTKGGTNPEVLPVVLWHGMGDTCCVPFSLGAIMNLIVEQTKGGYVRSLQIGGNVLIDWQSGFFIHPNEQVDYVCKQLLQDEHLAKGYHAIGFSQGGQFLRAVAERCPNPPMRNLITLGGQHQGIFGLPMCPTLTEKPCDYITRLLDNAAYAPEVQKALVQATYWHDPIMENKYRLGSTFLADINNELFINKFYIENLQKLKKFVMVQFLNDTIVQPKESQWFQYYTTGQNKVIQPFTESKVYQDLGLDKMHRQGQLVFLGVEGDHLAISKAWFIQNIVPLLLEK | 134 |
Q97W79 | 1.3.5.1 | ACT_SITE 278; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLVDQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSLDLVTDDKKVAGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYPSDVLISEAARGEGAILKNIKGERFMTRYAPKKLDLAPRDIVSRAIITEIKEGRGFPGGYVGLDLTHLGEEYIKERLALAV... | 28 |
Q70CQ1 | 3.4.19.12 | ACT_SITE 262; /note="Nucleophile"; /evidence="ECO:0000305"; ACT_SITE 615; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALERKKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRND... | 175 |
Q45495 | 3.5.1.88 | ACT_SITE 154; /evidence="ECO:0000250" | MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNSQNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKSYLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNGVMFYDHIDKENPFKEPENAIAIER | 183 |
Q5K6Z2 | 2.7.11.23 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MDLASQENSQRANRWDKGIKIGEGTFANVYKGTEKATGRKVAIKKIKVGEMKHGLDMTALREVKFLQELKHPNIISLLDVFSVKQNINLVLEFLDTDLEAVIRDKALIFQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAANGELKIADFGLAREFGDAGNKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILRVPFLAGETDIDQLKKTFHAMGTPTEQDWPGYTKLPDYHEVGSFPKNPWWNMISSIGREGQDLARELLRFDPAQRPSAKKALLHSFFTSYPPPTPPIALPKPLAELRPRELA... | 103 |
P44894 | 1.3.5.1 | ACT_SITE 233; /evidence="ECO:0000250|UniProtKB:P00363"; ACT_SITE 249; /evidence="ECO:0000250|UniProtKB:P00363" | MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRTHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLDILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNTGILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH... | 28 |
Q9ULX7 | 4.2.1.1 | ACT_SITE 84; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P00918" | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRL... | 199 |
Q9SXB3 | 2.7.11.1 | ACT_SITE 630; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGIHLGEIGIVLFPWFLWLSLFLSCGYAAITISSPLTLGQTLSSPGGFYELGFFSPNNSQNQYVGIWFKKITPRVVVWVANREKPITTPVANLTISRNGSLILLDSSKNVVWSTRRPSISNKCHAKLLDTGNLVIVDDVSENLLWQSFENPGDTMLPYSSLMYNLATGEKRVLSSWKSHTDPSPGDFVVRLTPQVPAQIVTMRGSSVYKRSGPWAKTGFTGVPLMDESYTSPFSLSQDVGNGTGLFSYLQRSSELTRVIITSEGYLKTFRYNGTGWVLDFITPANLCDLYGACGPFGLCVTSNPTKCKCMKGFVPKYKEE... | 99 |
T1G776 | 2.7.11.13 | ACT_SITE 466; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000550-1" | MADKDDDKEFVSGRIVQRRGAVRQKDVHKVKGHNFVAKFFKQPTFCSHCTDFIWGFGKQGFQCNECCLVVHKRCHEFVNFICPGADKGPDSDFLNKHKFKVTSFNSPVFCDHCGSMLYGLVHQGLKCESCEMIVHKRCEGNVPPLCGLDNTEKRGRINVKVSCKDASLTVHVIEAKNLIPMDPNGLADPYVKIKLIPEDQGRTKQKTKTIRTNLNPQWNEVFVFQLGPDDLSKRLSIEVWDWDRTSRNDFMGSLSFGISELFQKSQKQDGAKGDVVESGWFRLLNEEEGEFYNVPCTDDVSTSIIELKNKLKLSSQDSRT... | 100 |
A2Q3Z8 | 3.1.1.11 | ACT_SITE 373; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSSHKLFILLFTILFSLTLPLNTNTSITTSLNPNKLTSLKSLCKTTPYPKLCFNSLKLSISININPNIITYLLHSLQLAISETTKLSNLFHDVGTSNIVEKQRGSIQDCKELHQSTLTSLKRSLSGIRSSNKRNIADARIYLSAALTNKNTCLDGLDSASGTYKPILVDSIINTYKHVSNSLSMLSNHAPEPSNQKGHNKNLVSPKWLSKRLDFDEYDPNEMLVVSADGSGNFSTINDAINFAPNNSLVRIVIYVKEGYYDENVEIPSYKTNIVMLGDGSDSTVITGNRSVVDGWTTFRSATLAVSGDGFLARDIAIE... | 125 |
A0A1U8AZS9 | 3.1.1.11 | ACT_SITE 431; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDTVKSFKGYGKVDEHEDLEFRRKTRKRLIIISVSVILLLTIIVGAVVGTVIHKSKNDDDGQNEQTPSSSETSVAQSIKAVCSVTQYPNSCFSSLSSLAAQKTTDPEELFKLSLQVALTELSKLASLPTKLIPKVNGDPLLVLTLRDCQTQFEDAIDQLNMSISSMQVSQGEKLLSASKISDLRTWLSAAITNEQSCLDGLQELNSTTAANVLEELRVAMKNSTEFTSNSLAIVSKILTLLENLDIPIHRKLLDVGSDSDEFPAWMHPDDRRLLQETGVTPDVVVAKDGSGKYKTIEEAVVVVPKKSVKRFVIYVKAGMY... | 125 |
A0A287ASU1 | 3.1.3.16 | ACT_SITE 160; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 162; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | GARSCRRGIGAGGTRGSRCRGRPLSVQAASLPGPGREQEQACEQQWESESREPEPERAPAQAPQPSTSLVLTKQGLVSKSSPKKPRGRNIFKALFCCFGAQHVGQSSSSTELSAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPINNADFIVPVEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQ... | 144 |
A0A8J1MBX8 | 2.7.10.1 | ACT_SITE 836; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MPAAQLEVILSSLYRASNMKNICSARPGFWLQVANMLMLLCMGRSHSSLAIKCDIIKSSTVAQPAARISNMSTATDLGCYWSSENVIRAKLPVEVNVFDSVTLEVTLNVSGIVSCVWLLPDNITPCRMSQNWNSSFVISLDLVRMSEKHAGEYKLLINNDNVSFSVHIELKVKGKPRKPFFTETNNIVSCISEGYPEPTIYWLLCSSPHGRCINKTGTHLFSGTDIYGRRRVMNALDSRFLQDEYILCCVANTFGTECTQLYTIDLNSEGLLPKIFVKVGEPFIIRCRAMNETYKFRVEWSYNSTDQLHAFEENAYVNIQ... | 97 |
P38080 | 2.7.11.1 | ACT_SITE 181; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSITNGTSRSVSAMGHPAVERYTPGHIVCVGTHKVEVVNYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQDENGLNEMRNEVEVMKKLKGAPNIVQYFDSNASRRRDGVQGFEVLLLMELCPNKSLLDYMNQRLSTKLTEAEIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDAKNNFKLADFGSTSTCFPIVTTHQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPFEMTGQFAILHSKYEFPVNKYSSKLINLIIIMLAENPNLRPNIYQVLYHLCEI... | 99 |
A0A1U8JJ87 | 3.1.1.11 | ACT_SITE 429; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDSIKSFKGYGKVDEAEERAFKRKTRRRLIILVISIIVLLAVIIGAVAGTLIHKRNNSSPDTASPTELTPAASLKAVCEVTQYPSSCFSSISSIASSNANDPKILFKLSLKVAIDELSGLSQYPKKLQAETNNSQVKHALDVCGTVFDDALDRLNDSATSLEVGEVESLLSDSKIDDLKTWLSTVITDQETCLDALEELNTTKNFNATLFEELKAAMQNSSEYASNSLAIAAKFLGLLTNFRIPIHRRLLGFQKAAPSEFPAWVSPTERRLLQESKPTPNVIVAKDGSGHFRTINEAVQLVGKKNQSRFVIYVKEGKYVE... | 125 |
Q9LXI7 | 3.1.3.2 | ACT_SITE 301; /note="Proton donor"; /evidence="ECO:0000250" | MVKVLGLVAILLIVLAGNVLSYDRQGTRKNLVIHPTNEDDPTFPDQVHISLVGPDKMRISWITQSSISPSVVYGTVSGKYEGSANGTSSSYHYLLIYRSGQINDVVIGPLKPNTVYYYKCGGPSSTQEFSFRTPPSKFPIKFAVSGDLGTSEWSKSTLEHVSKWDYDVFILPGDLSYANMYQPLWDTFGRLVQPLASQRPWMVTHGNHELEKIPILHSNPFTAYNKRWRMPFEESGSSSNLYYSFNVYGVHIIMLGSYTDFEPGSEQYQWLENNLKKIDRKTTPWVVAVVHAPWYNSNEAHQGEKESVEMKESMETLLYK... | 145 |
Q08156 | 2.7.10.1 | ACT_SITE 777; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MEGAHLAWELAHAVLLLSLIPAGGSVPHEESSLVVNKGEELRLKCNEEGPVTWNFQNSDPSAKTRISNEKEWHTKNATIRDIGRYECKSKGSIVNSFYVFVKDPNVLFLVDSLIYGKEDSDILLVCPLTDPDVLNFTLRKCDGKPLPKNMTFIPNPQKGIIIKNVQRSFKGCYQCLAKHNGVEKISEHIFLNVRPVHKALPVITLSKSYELLKEGEEFEVTCIITDVDSSVKASWISYKSAIVTSKSRNLGDYGYERKLTLNIRSVGVNDSGEFTCQAENPFGKTNATVTLKALAKGFVRLFATMNTTIDINAGQNGNLT... | 97 |
G1KDL2 | 2.3.1.48 | ACT_SITE 464; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MSLLFQRNAGSSSDGTEDSDFSTDPEHTDSSESDGTLRQSARVTRSSARLSQSSQDSSPVRNPPSFGGEEPVYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRDTKNAADHDESPPRTPTGNAPSSESDIDISSPNMSHDESIAKDMSMKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQVEDRMLSHRQDDNNRHATRHQAPTERQLRYKEKVAEMRKKRNAGLTKEQKEKYMEHRQTYGNTREPLLENLTSEYDLELFRRAQARASE... | 61 |
P66815 | 2.3.1.286 | ACT_SITE 123; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000305|PubMed:26166706" | MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVDTKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSLMTE | 58 |
E9HCC1 | 4.1.1.50 | ACT_SITE 74; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 88; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 319; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MEKDNNENHHQEHYFEGVEKLLEVWFTRKDGAIQHCDLRKVPREKWVSMLKIVRCEIISMTRNDTIDAYVLSESSMFVSKRRIILKTCGTTTPLLCLKSLLYLVQRYAGYDEVQDLFYSRKNYKRPELQQEPHRTFADEAALLDAMFHDGAAYCLGAVNRDCWYLYTLNPYASPAGHSLSALLAGAADGDDGFGASDGEEGTDGSSSDGGCDGIEDSGSDGADSSDDSLDLRTMNLSGLNKRNVSQRYSISLGGGRGSSTSEADQTLEIMMSDLDPEVMKIFTKQFSANAAEATQKSGIDKILPNVTIDDYLFDPCGYSM... | 196 |
A9RGR1 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEWGSVLILLLLSSVILFSEGHLSSDYYKSTCPNVERVVRSSLRRAFLLDPSAPASLLRLSFHDCQVEKCDASILLDSVSNDINGERESGGNFGIRRLDIIDRVKQDLEKECPGVVSCADIVAMAGRDAVSYTGGPEIPIPLGRKDATTASSENADDQLPPASSTVSTMLQVFSRYGMTAAETVGILGAHTLGIGHCVNVVDRLYPTRDPALSTGLYLQLRVLCPTKEPLNLTILPNDLSVYSFDNRYFKDVLGGRGLFRADANLVGDARTKPLVAKFASDQSLFFKTFASAYVKLVSAQVLTGSRGEVRTNCRRVNAQD | 14 |
A0A1U8B3P6 | 2.7.1.11 | ACT_SITE 275; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MELSVSLSLSVPSHSRSLPSLFFCRRKKHNALLIFRNPNSTSRNCNSSTKLFNWLQKNVITALNSIQTGDGGFVLEDVPHLTDFLPDLPAYPNPLQKSTAYAIVKQNFVSTEDVVAKKIVVQKNSPRGVHFRRAGPQEKVYFESDEVRACIVTCGGLCPGINTVIREIVCGLNYMYGVEDILGIEGGYKGFYSKNTTTLTPKVVNDIHKRGGTFLRTSRGGHDTKKIVDSIQDRGINQVYIIGGDGTQKGAAAIFKEVEKRGLKVAVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVESVENGVGIVKLMGR... | 84 |
Q39799 | 3.2.1.14 | ACT_SITE 139; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MSFLQALSIFLLLLLYVVVGSAEQCGRQAGGALCPGGLCCSQFGWCGSTADYCTVPGCQSQCSGSGPAPGPGGLTNLISRETFNQMLLHRNDGACPARGFYTYDAFIAAARSFPAFATTGDQATRKREIAAFLAQTSHETTGGAGWAAPDGPYAWGYCYNRELNPPSSYCASDPNYPCAPGKQYFGRGPMQLSWNYNYGQCGRAIGVDLLNNPDLLSSDPTISFKSAFWFWMTPQSPKPSCHNVIIGAWSPSSSDRAAGRVPGYGVITNIINGGLECGKGWNAQVEDRIGFYKRYCDILGVSYGNNLDCYNQSPFGNGVS... | 158 |
A0A1U8I2S0 | 5.1.3.3 | ACT_SITE 169; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 301; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MADQPQIYELNNGTVVVKITNYGCTITSLSVPDKNGKLADVVLGFDTVEPYVKGASPYFGCIVGRVANRIKNGKFTLNGTEYTLPINKPPNSLHGGFKGFDKRIWEVAEYKKGDKPSITFKYRSSDGEEGYPGDVSVTATYTLTSTMTMKLDMEAVPETKATPINLAQHTYWNLAGHNSGNILDHTIQIWASEMTPVDENTVPTGEIKPIKGTPFDFTAEKKVGLQVHEVGLGYDHNYVLGSGEEKLGLKRAAKLKDPSSSRVLSVWTDAPGMQFYTGNHVNGVVGKGGAVYNKHAGLCLETQGFPNAINQPNFPSVVVQ... | 211 |
D8T676 | 1.11.1.7 | ACT_SITE 59; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIVVILTASLELGVVQSSTVVGYYSHSCPAAEKIVSQVVAEQFATRPLVAAGILRLYFHDCFVEGCDGSILLDASPDGTPPEKRSLANNNTATGFELVDAAKRRIEAVCPGTVSCADILALAARDSVAISGGPRWEEPTGRYDGRVSLASNADGSIPGPSFNLTRLIHSFANKTLDSRDLVTLSGGHTIGRSHCANFQIRLYNSSGTGLPDPALNPAYATALRRICPNTSPARRATLSLDRGSEIPFDNSYFVQLLAGNGLLRSDEELLLDGSMRGLISAFAANQRLFFREFAKAMVKLGGIGVKDSIQGEIRLHCRRVN... | 14 |
E7F2B6 | 3.2.1.143 | ACT_SITE 531; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 549; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 550; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MDSCNTEPKRHEVDVTMSDDAGSDEPEINESNQTGMTDDEKISELTRKRKEQNDESVNQNQSSLANCEIDTKGIIYRDTPASNDSSTQTKPSNGERASESNSPDPKVGKLTCLSTEKSETNLSLSLNAGDTTVEDVEMSPESPVCQAPQSSNSEEKSVCSDLPEGHLREGPTEEPKPSIPSPEPVKDTGDDIKDDSDVVPMETNDTEEPNSCAGASVSDNVPTTEPDSQTQASSLKSEQVPAEQEEPDWRGTPIENLRRMPKCGQTLPHLRATDNHRVLIRTDLLKEGQVPVPYPTKFRDSWDDMNVKMPCSEKNMFPME... | 159 |
U5FXM1 | 5.1.3.3 | ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 320; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKFFLFSCFVYLILFFANDDVEAVNEDIGIYELKMGDFSVKLTNYGATVISVILPDKNGKLDDIVLGFDSVDDYKNDTTYFGAIVGRVANRIGRAQFTLDGTDYKLVPNDGRNMLHGGPKGFSEVIWGVGSHDDNHVKFTYYSFDGEEGFPGDVAVSVTYMLVETNKLVVKMRAMPLNKRTPVNLALHAYWNLGGHSSGDILSHTIQLLASEITPVDEELIPTGEIVAVEDTPYDFHKPREIGSMFTQLPDGYDINYVLDNVNPGHLKKVAVVQEGVSGRKLELWTNQPGVQFYTSNMLDNVKGKGGFVYTQYAGICLE... | 211 |
A2FXS6 | 2.3.2.26 | ACT_SITE 660; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MEDIFLFQLTNGCEKIVCNNPNCANCPKFVLSNSSYIQKKQIALKMAQNEESKKSLCHHINILLCNEEARQILQDFEKFANNFTISTSPAEILQNINPVFTNFMYFCQLFTPKDKFITKTNLLINDQKFFNFSTILSSIPSLNTQIYNLISSIAIDIMNWKNSITISIIRGLLILFYFPSIFSPKSSESLLLSIFIFIKTKLEHQDRKLFISELSKCPNLINQIIGIVHCAISDFYANREKPDPYSQQVIYMLEVMNLAFLANERSNSPLPTSIFYNHHINDSFTQENRFSGHSDPLIEKFSFVLNLNTKIQICTLQTDT... | 65 |
Q8IKW2 | 2.3.1.286 | ACT_SITE 294; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MSCMNYASRLSKNEYKGPLGEEEFFEDTEEEKKKVKELIEKIRSSEYIVVHSGAGISTSSGLQDFRGPTGIWTNEHLNELKNKKKRNHDFKDNKRKLKSNDINCKNTSDMCSPSFFHKEKKENTLNIVKRERYYNEDNVDMNACNERVVHPNHVYVNHEDDNNNNNNNNNNDNNLYNNVYNSVGSNDHTNKESILIKKENNSENVRKDIHDKVNTKNVKKIDVKETNNLDPENYVIFGKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLHHRCGKHFSKTAEIHGNIFTERCDFCGRRYLRDYLISTISF... | 58 |
A4PES0 | 2.7.10.2 | ACT_SITE 341; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGDNGDNKELKQKLNFSYSEEEQEDEGQKEAQESKKVQYHTPERCGHQDSEAKFTPPRTPLNHVCELSTPQVKDRASPDQGLRTPVSRPHTRPETPAPPDKSKPPPHCESPFTPRGHSSQSVISTGKLPSRGSKHLRLTPGPLTDEMTSLALVNINPFTPESYRRQFLKSNGKRKTRRDLEEAGPEEGKVEKGLPAKRCVLRETNMACRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSTKPVSGLSDENLAMHEVYAHSVLGHHPHVVRYYSSWAEDDHMMIQNEYCNGGSLQAAISENAKSGNHFQEPKLKD... | 98 |
A0A072U9H8 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAMVSASRSLFISFLLASLILVSSERVARPPAVRGLDYDFYRLSCPRIERIVRKHLEDVFEKDSGQAPGILRLFFHDCFSQGCDASILLNGVDGEDDEKQHDANFALREEALQTIENIRAIVRKQCPRVVSCADILVIAAREAVRQFGGPDIDVPLGRKDSLNFSVNSPDNLPVPFARTDELLTVFGSKKFDATDVVALSGAHTFGQAHCPTMFNRVIDSDPPIEPNFKKQLEATCPNEESLNAVNLDVRTPNTFDNMYYINLLNHQGVFTSDQDLASHPKTKEIVNLFASNQKEFFNKFANAFVKVSQLDVLTGNQGEI... | 14 |
A9WKF8 | 2.3.1.181 | ACT_SITE 177; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013" | MRTLTVHYLGQIAYTAAWDIQRQLAAERSRGQIGDTLLLLEHPPTITLGNKARPDHVLASPAELAARGVAVVQSDRGGEVTYHAPGQLVAYPIFKLSQHGSDVGRYVRGLEESVIRVLAGYGLVGERVAGLTGVWVRNGAAKICAIGVKLSASGVTTHGLALNVDPDLSGFDLIVPCGITDRSVTSLAFELGQAPALAEVAERLIAQIGEVFALEPRVEALAM | 55 |
A0A1Y1I703 | 3.5.1.98 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MAPRKDRVSYFFDADVGSVYYGPNHPMKPHRLCMAHSLILGYGLHEKLEVYRPHKAYPQEFAQFHSTDYVEFLHRITPEMTDYYKDQLVRYNMGEDCPVFDGLIDFCKIYTGGTIDGAVRLNHGLCDIAINWSGGLHHAKKQEASGFCYINDLVLGILELLKYHARVLYIDIDIHHGDGVEEAFYMTDRVMTVSFHKYGDYFFPGTGDVKDIGERDGKFYAVNVPFKDGIDDAGFHKLFKPVMTKVMEIFQPGAVVLQCGADSLAGDRLGCFNLSIDGHAECVKFMKKFAVPLLVTGGGGYTKQNVARAWTYETAVLLDA... | 184 |
A0A2G3AA85 | 3.1.1.11 | ACT_SITE 22; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRKKLLNSHKFIRECNVSGTVDFISGSGRVIFQNSFVKARSPMEGQGIRILAPGADQNTPNPGLVLQNCELFPVSGFNRTEFSGVLGWPWKNQGKGVSLSSYISGFIDPQGWAPHLEVTDIYMAEYNNRGPGLDTKDRVKWSKVIDKEETFKFTVYNFLQGDKWISKIISHYLDHLDDSEDSA | 125 |
D6X2A7 | 3.4.19.12 | ACT_SITE 16; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 118; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 133; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MNLNDIYHEKQVRELCALHALNNLFQSKDAFTKPELDVICHSLSPDNWINPHKSVLGLGNYDINVIMKALQSRGYETIWFDKRKDPSCLNFKNICGYILNVPSEYKISFITLPLRRRHWITIRQLNGLFYNLDSKLESPQIIGRESDLLNYLKEELDCRDKELFLVVTNDVGKEQSWLKNQASYSNNLQEREAEIVQLRDITSDDVNVTINPLCNSRSDWS | 175 |
Q7S627 | 2.3.1.48 | ACT_SITE 755; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MADEQLRAEELQQSVMMSEHQAEASTADGDVAMVNQVTITSDMSNIIAKPEPSEADEDQEMHDAQEENDHHDEEMGEGDDAEHSDQGSHDGHDDHDHHEDSGDEHGEEEEHDGEDPEGFDEDAEGDEGDSVHSEEHTSQQHLPSVEEDHDDDEDDDDEGVGAVKIKPGDTDHSESESEEEEDDHSSASSASVSDAESEDEVHWEDAAEHEPAGDEDDDDEGSEKGDSGLCMFCKQDEDHDPAEEFEEYLACAGCGDNAHQQCAREANALASDQALDAWKCPNCASEEGSQTAAGKNHEPTQVNGTETITHPTTRRASAPK... | 61 |
T1FKE0 | 4.6.1.16 | ACT_SITE 220; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 228; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 259; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MIKVFFSNENYFIWTAEDACKVRKVFRIVGNMVGCLPSSPLQNAQMGLPLLLMQCEARLLVEKGFACIVDEFSIKKSKNHIQLIAQKRKQVFDEQVALCKKEKHHQMEINMQKIIDGKRKKIFNQNDEISAADLSKQIEEELLVERKRIDCLKLSQSSALVQTHTSRYPSEKIKDNKAQYAWKSSIDFHLDKKYYVFKYFWEQNYFITSGLKFGGDFLVYPGDPSRYHSFYIVLCVQHDEAINLLQLIRMGRQATTVKKTFVLASVDFNNTYNVNCVSIQWPKA | 207 |
K3Z7V2 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARRGNALAMGTLLLAAAVVCAAAAAEADDLLVELQLQQDPCPQVEDIVRSAVQKAVRRNIQLTAGLLRIFFHDCFPQGCDASVLLAGERDVPPNAGSLQPEALKLIEDIRREVHGKCGGPKVSCADILALATRDAVVAAGLPFFPITRGRMDTRTPAPDVLGNLPSPSDSVGNLLDMFRRKGLGDDPRVLVALSGGHTVGKTSCGLIRGNDDFSRALAANCSASRSRKQSLDVITPDAFDNRYFVALRNGKGVLGSDQGLADHPSTRDIVRDFANDQQLFFTQFRASMTKLSQLKAPAGGSRFEIRLDCSKPNARVGDE... | 14 |
A3DD66 | 3.2.1.39 | ACT_SITE 402; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 479; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352, ECO:0000305|PubMed:29870811"; ACT_SITE 483; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352" | MPPGAKVPQAEIYKTSNLQGAVPTNSWESSILWNQYSLPIYAHPLTFKFKAEGIEVGKPALGGSGIAYFGAHKNDFTVGHSSVYTFPDARADKISDFAVDAVMASGSGSIKATLMKGSPYAYFVFTGGNPRIDFSGTPTVFYGDSGSQCLGVTINGVNYGLFAPSGSKWQGIGTGTITCILPAGKNYFSIAVLPDNTVSTLTYYKDYAYCFVTDTKVEWSYNETESTLTTTFTAEVSVKEGTNKGTILALYPHQWRNNPHILPLPYTYSTLRGIMKTIQGTSFKTVYRYHGILPNLPDKGTYDREALNRYINELALQADA... | 167 |
A0A1U8BKT4 | 3.2.1.143 | ACT_SITE 273; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 291; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 292; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MENREDLNSILSFLPLGLQSSSLAWSSQVVETLRALSRGPDHSRVDSGEVFFLAISDMRESLRLSFHLLALSAAEGYALFFDDLMSRVEALKWFGEVVPVLAALLLRLPSLLENHYRDADDILSGRKEGLSGVKTGLRILGPQEAGIVVLSQELISALLACSFFCLFPTYDRGVKHLPAINFDCLFASLYTGYNEKQEHKIKCLIHYFERICSHMPMGCVSFERKVLPLNPDHSVISYPSSDFWSRSAVSLCHFEVLHSGLIEDQPCEALQVDFANKYIGGGALHRGCVQEEICFMINPELIISMLFLPSMADNEAIEIV... | 159 |
A0A072V2G8 | 3.1.1.11 | ACT_SITE 406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAGGAIETQNHASKKKFAILGVSSILLIAMVAAVAVGVKDGGQVESEGGNQIVKSQKIVQVLCGTTGYKQTCEKSLAKTGKTDMKELIKAVFKATAEELSKQIHNSKLYKELATNDMTKQAMDICKEVLGYAVDDVHQSIHSLDKFDIRKIDEIAYDLKVWLSGTLANQQTCLYGFENTTTHAEQTMAKVLKASLELTNNALDIINGLSGFVKDLNLSSLTSVLNNNRKHLSEDGLPSWVSQSQRKLLAAPENVKPNAVVAQDGSGQFKTLTEALALVPKKNQVPFVIHVKAGIYKEYVSVDKDRDHVTIIGDGPTKTIF... | 125 |
A0A061E9W0 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAGQKLLSFLLFQLILVLLVLDLSNAEGLKLGYYYKTCPKAESIIRKTTYRFISRAPTLAAPLLRMHFHDCFVRGCDGSVLLNSTKNSQSEKAAVPNLSLQGFHVIDAVKSAVEEACPGVVSCADTLALVARDSVSMIYGPFWEVPLGRRDGRVSLLNEVFANLPSPFANITTLKQMFAVKGLSLKDLAVLSGGHTIGTSHCNAFTNRLYNFTGKGDTDPSMDPNYIVKLKKKCKPADTTTLVEMDPGSFKNFEEDYFTLVAKRRGLFQSDAALLNDKETKAYVILQSSTHGSTFGKDFAESMVKMGKVGVLTGHQGEI... | 14 |
E7FBS9 | 2.3.1.225 | ACT_SITE 145; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q8VDZ4" | MPVGLSVGGALGDPSPSRPFRPSRYVPVSAATAFLVGATTLFLCFTCPWLSEKFSSFIPLYNVVVFLFTLANFCMATFMDPGVFPRAEEDEDKEDDFRAPLYKTVEVRGIQVRMKWCSTCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTVHIMDVFGFSLLYILHHTKQLDLVQSGVTMAVMCVAGLFFVPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTHGCFKNIAHVLCSSQAPRYLGRLRKPQSVQVQPPFLRPPLSEAQLAAKVLDNGIQQSKSSLEIMESQSTDADPPPP... | 57 |
H2XLX5 | 3.2.1.17 | ACT_SITE 40; /evidence="ECO:0000256|PIRSR:PIRSR001065-1"; ACT_SITE 54; /evidence="ECO:0000256|PIRSR:PIRSR001065-1" | NNMAYEKDLRAMETYKEGIIQAARNNNLEPSLIAGIASRESNGGRALDKDGLGDHGNGFGIMQVDKRHHTPIGGPYSNEHINQGATILRNSINAVEKKFPTWSPDLQLRGGVAAYNFGVSNVRTPDGIDRGTTGNNYSADVIKRAEYFKQNGY | 160 |
A0A0R0GDU9 | 3.1.1.11 | ACT_SITE 450; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEYGKLGPSDPGGSSRRSTVPLTNPTSSSSSASSKKKLIMLSLLAAVLIVAAAISAALVTVVRSRATSNQNGPHLAHNPTQAISRTCSKTRFPTLCINSLLDFPGSTTASEQDLIHISFNMTLRHVSRAFYASSGLSFAATNPKVSAAYNDCLELLEESMEALSRSLDSVLSPSALSGSTEVRPATVGSTEDVMTWLSTALTNQDTCAEGLQDTSGSVKDQMIDNLKDLSELVSNCLAIFSASGSGDFSGVPIQNKRRLMENKEEEEENVNRDISGKFPGWLNKRDRRLLSLPVSAIQADITVSKTGNGTVKTIAEAIKK... | 125 |
B8E199 | 3.1.26.3 | ACT_SITE 60; /evidence="ECO:0000256|HAMAP-Rule:MF_00104"; ACT_SITE 132; /evidence="ECO:0000256|HAMAP-Rule:MF_00104" | MRDRNIRNVKVEDIVERVKEKTRVSFNDKDLLIEALTHPSFKHENPNFKQDNQRLEFLGDAVLNMIITEILFQRYREASEGFLTQKRIYLVKEETLYKKAKSLDLGELILLGVGEEKQGGRDKISILSDLFEAFIGALYLDKGYEYTKNFVEEIFKEEIESIEMEVDWKNLLQTYLQKEGKKPQYIVSREVGPEHDKTFYVELWIDDEKISEGEGKNKREAEIKAAQKALEKIKNDLS | 138 |
B8BW07 | 4.1.1.17 | ACT_SITE 336; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | FYVVDLGIVGAQLARWRAAFPRVVPYYAIKCNPDPVIVRTLASLGCNFDCASRGEIEIVQQVSRGLPSGIPKPEIVYANPCKGRGHIIDAVCRGVRMMTFDNVAEVQKCAAVSRKIQLIMRIITDDSGSQCRLSSKFGAPKQHWPILLAEAKKFGLEVVGVSFHVGSGCRDATRYEMALKDCKELFEVAKRDYGFDMNILDIGGGFPGETHNKGNQYMYFNEIAAAVAPMLDELFPPSSGVKLIAEPGRYLVAASSTLVASVVSVREAAVSGIVRQAIADSVQPLQDDFAYYINDGVYGAFNNLLFDHATVVDEEADETS... | 195 |
Q54G43 | 2.7.11.1 | ACT_SITE 359; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDINLIKQYINSSLPNDKESLIQYYGQLKQILNALSDKEQQQLLNNNGKISEQQQLSIENNYKVIGSIEEKMKSIEHLFNNLDVSDSNNNNSTSPVFISLDNQNTVNNNNNNNNNNNNNNNNNNNNNNNSLAPTVILDNNDNKKTAEIILPDHHNNTPQQQPEQQVQQQQVQQQQQVQQQQQQPEQQQQHLTEEQIQKQQQSQASIQQAIANMGEKKRSSSRHSGPPEIPPEEIKFDVKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPNVVLCLGACTKPGKVMIVSELMQTDLEK... | 99 |
B1WAR9 | 2.7.11.1 | ACT_SITE 156; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGVVVAETSQNGDISLLSEKKFTVPQPPSIEEFSIVKPISRGAFGKVYLARRKNNNKLFAVKVVKKADMINKNMVQQVQAERDALALSKSPFIVHLYYSLQSANNIYLIMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLKRELSMMDILTTPSMAKPKRDYSRTPGQVLSLISSLGFNTPVGGRTQGSIAQQTEGMRGNASTPLLMKKKENSVKGNKLMISCPEAGLSSPSMPVKCLTPNLLKCRTPFTTSSTSSQSRICLSSLESECGMSPRWENC... | 99 |
Q9VM90 | 2.7.11.1 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGTIEKRSFSFRLRRSFGDGGSTNSRNSNNNSSTCTNHNNQKRCSTPLTPTSTSTGRLEVPGAASVSRRSSIYKKPDKNDGGQIHLIPDVELPLMTFADQYNIEKTLAEGCFAKILLCRHRPTNTLVVLKAVHAELTTIKEFQKEFHYNYELSHHHHILSAYAVAFQTMDYYVFAMEHAPYGDLASNIGPNGLHENACKLISEQLSSALGFMHSKNLVHRDLKIENILVFTPDFTRVKLCDFGATTKKGLLVHKVKHTWTSCVPPEQLELIKNERFQCLPVSDSWQFGILLYNILTGNPPWQSADWVKDQSYANFMKYEQ... | 99 |
P54199 | 2.7.12.2 | ACT_SITE 563; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSTNSFHDYVDLKSRTNTRQFSDDEEFTTPPKLSNFGSALLSHTEKTSASEILSSHNNDKIANRLEEMDRSSSRSHPPPSMGNLTSGHTSTSSHSTLFGRYLRNNHQTSMTTMNTSDIEINVGNSLDKSFERIRNLRQNMKEDITAKYAERRSKRFLISNRTTKLGPAKRAMTLTNIFDEDVPNSPNQPINARETVELPLEDSHQTNFKETKRNTDYDSIDFGDLNPIQYIKKHNLPTSDLPLISQIYFDKQREENRQAALRKHSSRELLYKSRSSSSSLSSNNLLANKDNSITSNNGSQPRRKVSTGSSSSKSSIEIRR... | 108 |
O84469 | 5.4.99.12 | ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MTKKIVLQIAYQGTSYSGWQYQPNALSIQEVLETILKKIAGFRISVISSGRTDAGVHAQGQIAHFHCPDHPHFTDPRQIQKMLNALLPHDIVIRDAVMTDEDFHSRFSAIAKEYRYTLSLLPKPLPHHRLFCFSPRYKLNIARMQEAAQYLVGTHDFASFANLGREYSSTIRTLYTLDLSEQEHLVTVICRGNGFLYKMVRNIVGALLDIGKGKYPPEHLLDMLATKDRRKGPPSAPPYGLSLHHVCYPPPYQWFCKHEHNNSSEGK | 217 |
Q55DB0 | 2.3.1.286 | ACT_SITE 152; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MTDDIVFENMVIDDTIVEEEDVEMKYYLKNKKEFEFLAKEMLSGKKILFITGAGLSINSGISAYRNTKTSVWSNFITEWGTRKKFEQDPAQFWNHFWLRTHEKQEYLDALPNSGHLAISNFVEYLGSNVITQNVDALHLKAKVPIEKLVEVHGRISLYKCITKGCRFEYDDTIDNIEIGDYSINGTTMKQGNLEITPPLCPECKKPILPQSLLFDENYSSHQFYNIEKAMDWIQEADIFIFIGTSFSVGITEEVICHAQSERKKMFNFNIFKETKISGLKSIVGKSEITLPLLERQLLYEAQKRNNGKKQIWYGNTIKRI... | 58 |
A0A804JYR3 | 3.1.3.48 | ACT_SITE 129; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MPYLVRDRLFFGDIKAAAEVLKKGSAEITHVLSLLSSASISFFSGWRADMCIPAEEIKKVFVGAEGSPRKSLAPEKLLYSLEHAGPELKLVRMAVPLKDTEDEDLLDYLDACLDFIDQGRKEGSVLVHCFAGVSRSAAVITAYLMRTEQKSMEDALESLHEVCDLVCPNDGFLDQLSLFEEMGFKVDTESPIYKRFRLKILGHSYKQGEKIDSFVFGADPGLPPSEFNPSEEALEGNQRSTAYRCKKCRRIVALKENVVSHVAGEGETCFEWQKRKASNRANNRFQEQQCSSLFVEPLKWMTSVEEGALEGKLSCVHCEA... | 149 |
A0A1U8ASQ4 | 2.3.2.26 | ACT_SITE 1003; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFFTGDSSTRKRVDLGGRSSKERDRQKLLEQTRLERQRRLGLRQQNSAAIKIQKCFRGRRAAEAERFKVREQFCMIFGDHCQKVDRGCFNHDSQFLCQLLFFFNAHNSGDFAILVGTCRLFHLFVRDSGDTLGLFAGANYSLKNTVENRVKRLANACLKAVHQNRDWLKDHLLMSYQFSSSPITILLETVVVLTDPKLPWVCTIVGYLTQRNIFALLRDIILTGKKSMKAQDSGGKISSLEHVIMLIISHIGHQPCSCPNIDPRWGFSSQILTIPFLWQLFPYLKEVFAKRELSEHYIHQMALCVHSHANVLPDDLSPEF... | 65 |
Q582T6 | 6.2.1.5 | ACT_SITE 255; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MLSRTVRRLWINQNTKVICQGITGKHGTYHTEQAIAYGTKMVGGVNPKKAGSTYLNLPVFGTVAEAVKNTGADATVIYVPAPHCAAAVEEALVAEVPLVVVITEGIPQWDMLRVKSMLLSQNKTRLIGPNCPGIIRPEECKIGIMPGHIHKKGCIGVVSRSGTLTYEAVAQTTAVNLGQSLCVGIGGDPFNGTNMIDCVKLYLEDPGTEGIILIGEIGGTAEEEAAEFIKNHPIKKPLVTFIGGATAPPGRRMGHAGAVVSGGQGTAKGKMEALEAAGAVVAHSPAQLGALMAELMKKRAI | 247 |
B8C892 | 2.3.1.48 | ACT_SITE 245; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | WKYYVHYRDFNRRMDEWITMDRIVSPPSEHLAVDVVTTIAAPVLDEHEGMDDAALKEHEEVTKVKNVATLELGPYQMDTWYFSPLPKELFKDGGVVDVLYVDEFSLNFFTRKSELLRYQAKELPKNRRHPPGNEIYRCGNLSMFEVDGFEERIYCQNLCYIAKLFLDHKTLYFDVDPFLFYVLCEVDERGYHPVGYYSKEKYSDVGYNLACILTFPSHQRKGYGRFLIAFSYELSKKEEKVGSPEKPMSDLGQQAYIPYWTSTIVDFMLNHSGNDTSMSIMDIAKKTSIMAEDIVFALNTLGILKFVNGVYFISAERGML... | 61 |
A8X232 | 3.1.4.11 | ACT_SITE 355; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 403; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAKEFQFNWKPNIPPSLAQGACFDRYDDESTCLELNAQVRVDEYGFFFFWLVEGKDAVVLDMGQIWEARPGGLPKDGRIMFELEQRGASETIAERTIWVTHGQDLVNVQSFFLVAESVEMAKMWRTGMNEILKTSRIRHVCPTTQLLKYWKWLTLNVNERRKIPIKVIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPVRVINRSMGKKFRNFYKCSRGRKRKEREELDVEILTFEKFLRLYNKICPRTEVQELFVKLSGQKEYLTKDRLINFLNEEQRDPRLNEILFPFFDPPRTGQLIAKYESDNNYIENGKMSGDAFL... | 153 |
O61847 | 2.7.11.22 | ACT_SITE 170; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSREIRSLESIISDARENTHEKMLIRKQRDMTTDIAPERDLQGRFCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYANSKLYMVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPVNLKKLEETSCLTGNGLDVLREILRYPPERRLT... | 102 |
A5HY32 | 2.7.1.21 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MYGPKDHGWIEVVAGPMYSGKTEELIRRIRRAEIAKQKVQVFKPEIDNRYSKQDVVSHAGDKIQSVPVKSSKEILEKLLDDTDVIGIDEAQFFDDFLVEIVSKIANNNRRVICAGLDMDFKGEPFGPMPKLMAIAEFVDKIQAVCMVCNNPATRTQRLINGKPAKKSDPVVLIGAQESYEARCRKCHRVPR | 88 |
A0A8V0YKS4 | 2.7.10.1 | ACT_SITE 1009; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MPSVPGEAGASRARGSTALCPQPPHRRARCPREERLPLIARREGLGRTRRGSKLSPSGLRRDGLCRRGANQRRRGEELSRSRRNIRARDGRLPAAVTSRRGSHSYPRGLRLAPRVSVPPAPVPRTVRPLRPEPPLRRVQRTRGSRQFVSSSNQPAAASHGATGPAPPSRRVRGGRLIHETGSTRSLHLLLAMGTPPRTFLILGCFLTGPLLTLCQLPLPTIVPNRNEMVVQLNSNFTLKCSGDSEVSWQYPVTEGSHRIDIRHEENNSGLFVTVLEVGNASAAHTGMYVCYYNHTQVEDGEVEGKDIYIYVPDPDMPFVP... | 97 |
C5X4J0 | 3.1.1.11 | ACT_SITE 158; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATVPVDVVVAADGSGDYSSVSAAIAAAPLKSNKRHVIHIKKGLYKEFVILGEDAWNVTLIGDGMDATVISGSRCCADGFHTPQTAVLTVLGRGFIARDLRVENTAGPRKELGQAVALLSNSDQSVVFRCALRGYQDTLYAELGRQFYRECKISGTVDFIFGDAAAVFQNCDILARLPIQGQQNTLTAEGRDKPDSNGGFCFQSCTVAADDDLAKASGVETYLGRPWKAYSRVIFMKSTISNVRHAKGWLPWEHAAPPDTIYYAEYDNDGPGAAVGGRVKWSGFHTIQDAAEAINFTVEKFINGNDWLPGTGVDYKPGL | 125 |
F5HD81 | 2.5.1.18 | ACT_SITE 15; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MVPKPKITLYLDTVSPFAYEAYHILRNDPIFKNVDIKYVPIFLGGLMNKCSNTPPIKIKNKDKWINVERLRWAHAFSVPIVTDMPPNFPPNTLPVQRVLAGIEASSSQSQSAVIAALDALYKAFWALGQPIYEPAQLRSVLASSLGGEEAADKVLGAAQTAEVKQRLVENTDKAFAEGAFGLPWFTCTNTKGETEGFWGVDHLGQVVQFLALDKEASGNGGWKSVL | 77 |
A7RLD5 | 2.3.1.286 | ACT_SITE 106; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MAGAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDPRPFFCLAKTLYPGNYQPNYVHYFVKLLHDKGFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCISCHHSYDGEQIRKTIENGDIPRCETIKCKGVIKPDVVFFGEDLPKRFYSFEIDFRKCDLLLVMGTSLEVEPFAGIVNEVSRSTPRVLINRESVGPFLHPWRRRPKDVVLKGDIVSSVKRLAKLLEWTDSMDNIIETADKEWEGKKSAKKPSDASDALAKDIAKTTCNRPVTPSDSSTSSKTTDRNNSRSLHTMVGSPSRSRDQLF... | 58 |
Q9KTN7 | 3.5.4.33 | ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MSAISARITVFKNPWSVILSASLFSAQDEQFMRRAIVLAAQAEAQGEVPVGAVLVRDGEIIAEGWNGSITNHDATAHAEIEVIRKAGKALSNYRLLDTTLYVTLEPCPMCAGALLHSRVKRIVYGAPDLKAGAAGTVMDLFSSQAAYHYATVEKGLLEEECRAQLQAFFQRRRKEIKAKRDAERKNAERKNER | 186 |
W5M5I9 | 2.3.2.26 | ACT_SITE 855; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MASASSSRSGVGQSSEKSQLTLKVLSAKPQSPKSPSRHSRLNSFVEVTADGLSSETKKTGKRCGHPELQWNEDLTLNVTPQSHLDLKLWSCHALRNELLGIASIDVYDTLKSNNGKMENVQLNLALQTENKGSLVPGGELTVCLDGLAVDLGSLPNGSAVTDKPQQSDGHGIRRTQSEDSPPSSSGSCSGPRGRSHRHSAGMARGGPVANGDPAVNGEHSPGARSRRRQTGKALSSNTGLGTPGKAEVAANGTEDGRRSPTCQTPPPSAALSTSTTPCAGTPSSGSDAPQGDTGETGGTPTPDQASAAPEQNMESLPPGW... | 65 |
H2L975 | 2.7.10.1 | ACT_SITE 995; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MFWFGCFKLGIFILFCSPFTTGHAGRRPKILGPDQQVLHKDQTLTLTCRGHGALNWTLAQRLLSSDGVKVERCHSKHHSHCSKLTVTQLVVSDTGRYTCRSSKAGSEYTTYVFVKDPDQPFVEKNSTTSVLLNYRHESSLVIPCRTTSPNTSVTLTALPNLSRDVVQQMEWDPKVGFKIRYGPYKTYSLLTCNSVIKGRHFKLFYIPKRLSSMLQNAKITPDRVKVLIGDTLTINCSAETSANGVIDFSWDYPNRNKKHQTYPYQNITGSLKVMKKSLRIENVTLEDRGVYHCKAELEPSKHLNVSARVYVFEHPFINVS... | 97 |
Q7F9K4 | 3.2.1.21 | ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 440; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MAVAGAMVMSGGVLLLLLAFTCAAYNDAGELPPISRRSFPKGFIFGTSSSSYQFEGAAAKGGRGPSIWDTFTHQYPDKITDKSNGDGACNSYHLYKEDVRIMKEMGMDAYRFSISWSRILPNGSLSGGVNREGINYYNNLINELLSKEVQPFATLFHFDTPQALEDKYKGFLSPNIINDYKDYAEICFKEFGDRVKHWITFNEPWNFCSMGYASGTMAPGRCSSWEKGKCRVGDSGREPYTACHHQLLAHAETVRLYKEKYQFTEEAIRQSPFIRDNNLNRRSAKALQKGRIGIILNSEWFVPFSQSKSSNDAARRVLDF... | 161 |
C0HKB8 | 3.1.1.4 | ACT_SITE 46; /evidence="ECO:0000255|PROSITE-ProRule:PRU10035"; ACT_SITE 92; /evidence="ECO:0000255|PROSITE-ProRule:PRU10036" | NLIDFKNMIKCTTKRSVLDFADYGCYCGSGGSGTPVDDLDRCCKVHDDCYGEAEKVHGCWPKWTLYSYDCSNGQLTCKDNNTKCKDFVCNCDRTAAICFAKAPYDDNNFMINNPRCQ | 130 |
A2QKT4 | 3.2.1.78 | ACT_SITE 206; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 314; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036" | MKLSNALLTLASLALANVSTALPKASPAPSTSSSAASTSFASTSGLQFTIDGETGYFAGTNSYWIGFLTDNADVDLVMGHLKSSGLKILRVWGFNDVTSQPSSGTVWYQLHQDGKSTINTGADGLQRLDYVVSSAEQHDIKLIINFVNYWTDYGGMSAYVSAYGGSGETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRCPSCDTSVLYNWIEKTSKFIKGLDADRMVCIGDEGFGLNIDSDGSYPYQFSEGLNFTMNLGIDTIDFGTLHLYPDSWGTSDDWGNGWITAHGAACKAAGKPCLLEEYGVTSN... | 172 |
B9N6K4 | 3.2.1.52 | ACT_SITE 338; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MTSNLVISSRCSLFLTLFYLLVSASLTATSAQWVWPKPRTLSWPIPLATILSPNFTISSPYHQHLSPAVNRYRLQILTEHHLPLVPPPFNLSNSSPPLQALTITVKDLAAPLQHSVDESYALAIPTASSTANLTAETVWGAMRGLETFSQLVWGLKPLLVPVGLDVWDSPLFEHRGIILDTSRNYYPVDDILRTIKAMSANKLNVFHWHITDSHSFPLVLPSEPALADKGSYGNDMLYSPADVATIVRFGLEHGVRVLPEIDSPAHTGSWAEAYPDIVTCANMFWWPAESKWADRLASEPGTGQLNPLNPNTYQVLKNVI... | 170 |
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