Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
B5YK47 | 1.3.5.1 | ACT_SITE 284; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MEINKHYFDTVIIGSGLAGCRAAIECINHGTVGVLSKLYPTRSHSTAAQGGIGAALGNEEEDSPEWHTYDTVKGSDFLGDQDAIEIMCYDAIPTIIELEHMGVPFSRTPEGKIAQRRFGGHTREFGKAPVRRACYSADRTGHAVLFALYEQCQLKGVRFFQEFQVLDIVVENNAVQGIIAVNIKDGSLHVFESKAVIIASGGYGKVFKVTSNAYASTGECLSMLFRQGLPLEDMEFFQFHPTGLYGLGILITEGARGEGGILINGKGERFMERYAPTIKDLAPRDMVSRAILTEIREGRGIDGKDYVYLDLRHVDRKILE... | 28 |
A0A2I4GGH5 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKIETNIILLSVCIVVTGFLGVCQGGNLRKNFYKTTCPSAEKIIQDVTWKHVCSNPNLPAKLLRMHFHDCFVRGCDASILLNSTADNTAEKESPPNQSLSGFDVIDDIKAQVEKQCKGVVSCADILSLAARDSVSFQFQKPMWEVLTGRRDGTVSRIAEVLSNIPPPIFNFDQLKNNFARKNLTMHDLVVLSGGHTIGIGHCIAFTNRLYNFTGRGDQDPSLNPTYAEFLKKKCPSPTDAITTVEMDPGSSQKFGSSYYTILLQNKGLFQSDAALLTSKQARNTVKELVSQIDFFTEFAQSMKRMGAIEVLTGTAGEIRK... | 14 |
A0A0D1CJR1 | 2.2.1.1 | ACT_SITE 421; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MSFTKAASDEKAIAAIRVLAADVVAKSNSGHPGAPMGMAPMAHTLFSRFMNVNPAHSKWINRDRFVLSNGHACALIYILNHLLGYKDLPMEQLKQFRQLDSKTPGHPEHGHTEGIEVTTGPLGQGFANSVGLAIAQANLAATFNKDGFPLFTNHTYMFTGDGCLQEGISSEAASLAGHLKLGNLIALYDDNHISIDGDTACSFTEDVEQRFLAYGWHVSHVLDGDKDLEGLFKAITEARNVTDKPSIIRVKTTIGFGSKLQGLAATHGAPLKADDIEAVKTKFGMDPKQSFVVPDDVYAAYKEIADRGAKADKEWTELFK... | 51 |
H2MZV1 | 2.7.10.1 | ACT_SITE 1191; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MGGVRTFAVFKKFLVLLVLGTSAVARPTITPNLKELFLQPHSFLNLTCFGESKKVSWVKPLPENSIVITGNNSATLLISRVTVGNTGFYVCNYEEQQDSEVDIYVFVTDPSNLFVPESPENIHLILSQHMVEIPCRVSHSNAHVILRRVPSGEPISSPYDAKIGFFGIDVPGQYQCESSVNGHTVKSDIYIVTHEDSCRNFTLEVTATERTVRAGQPLNITCMALPGSNYKQEWVYPRTQAVNATHIREKFSDHASFTISIPKTRPQDTGIYECAVECLESGYVRSSNVAVTVFEESSFIVLDHSGIFETEFISLLEETQ... | 97 |
Q12469 | 2.7.11.1 | ACT_SITE 507; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKGVKKEGWISYKVDGLFSFLWQKRYLVLNDSYLAFYKSDKCNEEPVLSVPLTSITNVSRIQLKQNCFEILRATDQKENISPINSYFYESNSKRSIFISTRTERDLHGWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDYNGLDTMQFNDHLNTSLDLKPLKSPTRYIINKRTNSIKRSVSRTLRKGKTDSILPVYQSELKPFPRPSDDDYKFTNIEDNKVREEGRVHVSKESTADSQTKQLGKKEQKVIQSHLRRHDNNSTFRPHRLAPSAPATKNH... | 99 |
Q9FGW5 | 2.7.11.22 | ACT_SITE 426; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAGGVDVSRSSVAVKKDYDFYRNGSRDVYVRQSGRDDERRQIKRPSDHDLRRNDGRHRSRLAYEKGELREEAEVQRPSEKRRKFSPIVWNAEKVGRAPSREKTKSPFPVPTTTVISNQAVAGKTTSNDQVNALMSPEPSYLAPVQPSEALLAVKHPVDDLEEGQLEEEQVMQEDVKEGLLEEEQVMQEPNIKTSRWGTGLTSPKEELISVNVSKTNRWNRSSLTPECEEVMVSEEQQCYSSGSGSGHLSVEKLSADGNSGREYYSSDHDELEHEDQDSLTPGEMNMMFGSRSVNEFQKLNKINEGTYGIVYKARDEKTK... | 102 |
Q9RVT0 | 4.2.1.20 | ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MTATPETATNRGVQRLHAAFARAEAEGRAAFIPFMTGGYPDAARFGEVAGDLLARADIMEVGIPYSDPLGDGPTIQRASEQALAGGTSTRRTLELVRELRQKDDTPIVIMTYINPIYAVGPAEFMRLAQEAGVDGLILPDLPPDQDLEIADLAAQHGLAVTFLIAPTSTPERVKLVAEACTGFLYAVSVTGVTGAREGAALGEVPRMLDLARQYAQRPVVVGFGVKDAATAQQVAQVADGVVVGSAFINAVAAGRDVGALADELAAGCRR | 202 |
M3XDN1 | 3.1.1.3 | ACT_SITE 168; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 191; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 279; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MFGIWIAALLFFGTSMGKEVCYERVGCFKDGFPWTGTLSRQLAGLPWSPEKINTRFLLYTRHNPKAYQEISAVNYRTIQASHFGTDKMTHINIPGWKSDGKWQQDMCNVLLKVEDVNCINVDWINGSLEYIHAVNNLRVVGAEVAYLTDVLMKKFGYSPSKVHLIGHSVGAHLAGEAGSRVPGLGRITGLDPAGPYFHNTPNEVRLDPSDANFVDVIHTNAVRLLFEFGAGTINACGHLDFYPNGGKHMPGCEDLITPLFSFDFNAYKEEVASFFDCNHARSHRFYIESILNPDAFIAYPCRSYRSFKAGNCFHCPKEGC... | 128 |
H2XVW1 | 3.5.1.98 | ACT_SITE 781; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MGERQYQEKLKRMRHQHEIENQLLMAQFNYQTSNLQHQHQLQQHLNITNEINNVIFVWEFLFVQRLKHVISKQRERVAEQMAALDQRSELINSVRNKEKNREKTGAVASNAVKQHLQKFVKCRQKFKDSHPSMERLLHISPGGNYLACFTYVVTHRSPLQWTPSLEGKNGGHEVPAHYSSLLHTQYDFPLRKTASEPNLKLKSRLKQKLLEDRVERSSPLMPRRGDIKADLANRIKKKINIENVNEQRNSHNSAPNSGPSSPPNSSNDIKQSTPHMQTEFYNQQTDYYEESNSSGNHDLYSSPSLPNISIGLTNKKSTVY... | 184 |
P23291 | 2.7.11.1 | ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSMPIASTTLAVNNLTNINGNANFNVQANKQLHHQAVDSPARSSMTATTAANSNSNSSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSL... | 99 |
G7J9J2 | 2.7.1.21 | ACT_SITE 102; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | MASSLGVGSSHSHSSSGEIHLFVGPMFAGKTTSLLRRIKSEVDNGRNVAMLKSSKDNRYAVDSVVTHDGIKFPCWALPDLMLFKDKYGHEAYQKLDVIGIDEAQFFEDLYDFCCKAADEDGKIVVVAGLDGDYMRRSFGSVLHIIPIADTVTKLTARCELCGKRAFFTLRKTGEKQTELIGGADLYMPVCRHHYVNGQVVVEAAMKSVFGSQKVGCGSLIETAPVV | 88 |
A0A1U8MIP2 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAVVVALAFVFLVMVPAPSLVRALSSNYYDHTCPHLESIVASAVKKAMSNDKTVPAALLRMHFHDCFIRGCDASVLLNSKGKNKAEKDGPPNISLHGFYVIDEAKKALETSCPGVVSCADILALAARDAVFLSGGPTWDVPKGRKDGRISLATETRQLPAPTFNISQLQQNFAQRGLTIEDLVALSGGHTLGFSHCSSFQNRIHKFNATVDVDPTMQPSFAAKLRSVCPAHNKAKNAGSPLDSSNLVFDNAYYKLLLQGKSIFSSDQALLTTPKTKALVSKFASSQEAFEKAFVTSMIKMSSLSGGQEIRLDCRVVR | 14 |
M9PD70 | 3.1.3.1 | ACT_SITE 123; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MRALRFFAALALQLTACSSQYKYGPEQSWDLDSISELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDGDVGKRLRVVMGGGTIKFLPNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLNNDAQNTDFLLGLFNASHLAYHMDDSIDTPTLP... | 141 |
Q38860 | 2.3.1.199 | ACT_SITE 223; /evidence="ECO:0000269|PubMed:11341960, ECO:0000269|PubMed:12135493"; ACT_SITE 302; /evidence="ECO:0000269|PubMed:11341960"; ACT_SITE 387; /evidence="ECO:0000269|PubMed:11341960"; ACT_SITE 391; /evidence="ECO:0000269|PubMed:11341960, ECO:0000269|PubMed:12135493"; ACT_SITE 420; /evidence="ECO:0000269|PubMe... | MTSVNVKLLYRYVLTNFFNLCLFPLTAFLAGKASRLTINDLHNFLSYLQHNLITVTLLFAFTVFGLVLYIVTRPNPVYLVDYSCYLPPPHLKVSVSKVMDIFYQIRKADTSSRNVACDDPSSLDFLRKIQERSGLGDETYSPEGLIHVPPRKTFAASREETEKVIIGALENLFENTKVNPREIGILVVNSSMFNPTPSLSAMVVNTFKLRSNIKSFNLGGMGCSAGVIAIDLAKDLLHVHKNTYALVVSTENITQGIYAGENRSMMVSNCLFRVGGAAILLSNKSGDRRRSKYKLVHTVRTHTGADDKSFRCVQQEDDES... | 56 |
A0A0A0K6S6 | 3.1.1.11 | ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MENTKLSLALFATLLLTNAIIVRANSNENGVMNNILSVIETSCAITLYPQLCHSTISSILGTSNLLSLKDIVELSLSVAMDAAKLNNENIKKLSMSGNIVGKRDRIALHDCVKTTDRTIYELDKAIQDFSEYPNKKSLASYADDLKTFLSSAITNQVTCLDGLSHDKTEKRVLRLIENTHNQVTKLCSNALALVKKLTTDVALTDEKSLVVHDFPYKITSISSQIDDPKIVLFSNQEDGESRRREDLENGIKWPEWMSIQDQMLLDSSSEEAADVVVAADGTGNYKTVSEAVKAAPSKNSRYIIKIKAGVYRENVDVPSS... | 125 |
T1EY64 | 5.3.1.8 | ACT_SITE 286; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MTSIGKVVPIVGVIQNYAWGKKGTESEVAKLYKGSIPSFNIQPGSPYAELWFGTHPKGPSKLLENSELLTSWLSKNLQQASCNHSNELPFLLKVLSVDTALSIQIHPNKLEAGELHKWNPREYPDSNHKPEMAIALTSFEALCGFRPLQEIEHYFCDLDELKILTKLVTDSAHHVTTAGKIFQTELDFKNSFVSLMNCDAGIVKEQAASLNGRISKNNEMKSDPNHALFLRLHCQYPGDVGCFCVYFLNYVTLKPGEALFLQSNLPHAYIHGDCIECMANSDNVVRAGLTPKFRDVDTLCRLVKYENRQIRDVLFDSLAK... | 214 |
A9PCH8 | 3.1.3.3 | ACT_SITE 89; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 91; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MEGLVHYRINPIHATRRQYHSCLVPAFSLLLSKNFTKTPVLFMKGHRSFNSVVASVQPLDASGLGHFDNTLPSKVILQLWRSADAVCFDVDSTVCLDEGIDELAEFCGAGKAVADWTARAMGGSVPFEEALAARLSLFKPSLPQVQEFLETRPPKISPGINELVKKLKAKNTNVYLISGGFRQMINPVASILGIPPENIFANQLLFGSSGEFVGFDVNEPTSRSGGKATAVQKIRKVRGYKALVMIGDGATDLEARKPGGADLFICYAGVQLREAVAVKADWLVFNFADLINSLE | 147 |
A9V5M0 | 2.7.7.7 | ACT_SITE 91; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MATRTTTTVTAKRKQPAEAVTAAKNAKGNANAEICDFLNQLADYERNVSRNIHKYNAYRKAARSIAAHSLPLRSGKDAQRLDGVGKKIGEKIEEFLTTGGLKKLDKINANPEAAAIQLIASVVGFGPAAAQNYVQKGITTLEALKQEDGLSNAQKIGLKHFADFNERIPRAEVEALRQAVFAELREVDDRLEGQVCGSFRRGAATSGDIDILLTHPDFKSTGDGEALGKTKKKLDPPFDKLLDRVISHLKKVGLVTDVLSLGESKFMGVARLPETQFSEAGLAPPRRFRRIDMRLWPVDQYPLALLYFTGSDETNKTMRR... | 121 |
A0A9J7MIV2 | 3.2.1.143 | ACT_SITE 538; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 556; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 557; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MSTGNCHRDSETGEPAKKRFRQTSILDSFSFRRKLSKRAEEAQSRVEEAILSDLANEKKEEMSDNRGEEMSQQMRERAAEAAERRRSAKSPWSTPPHESHDDQPANQGPASHHRHHKSHDSPSSHPSSSRHGRHRLSPSGVVPRASKYVDEEKPSTSRDTLSTSHHGRRDHKHKRRSRSDSSPEYGGPDSPLVIPDSPTVIPESPVLSEPPTDSPASPSNQSDTLVYEDSEPVFSNSDVLSQRDPSQPSWFGTPISALNRTPACSSPLPSLKPDSQHTVLFRPHVRPGDPPRPFPDKYRDVWDDAHVRMPCSDENLYPVQ... | 159 |
Q8PBU9 | 1.1.1.100 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MSKPLQGEIALVTGASRGIGAAIADTLAAQGATVIGTATSASGAAAIGERLAANGGHGRELNVTDAAAVDALIDAIGKEFGAVSILVNNAGITRDNLLMRMKDDDWQAIIDTNLTSVFRTSKAVMRGMMKARKGRIINIASVVGVTGNPGQTNYAAAKAGIIAFSKSLAKEIGSRGITVNVVAPGFIDTDMTKALPEDAKTALLQQIALGHLGQPDDIANAVAFLAGPPARYITGETLHVNGGMYMP | 2 |
F6U6B8 | 3.1.1.3 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 195; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 282; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MLPSWTIGLLLLATVRGKEVCYTPLGCFSDDKPWAGTLQRPLKSLPWSPEEVNTRFLLYTNKNPDSYQLITARDVATIKSSNFQSSRKTHFVIHGFRDRGEDSWPSDMCKKILQVETANCISVDWSSGAKAEYTQAVQNIRIVGAETAYLIQQLLTELSYNPENVHIIGHSLGAHTAGEAGRRLEGRVGRVTGLDPAEPCFQDASEEVRLDPSDAQFVDVIHTDASPMLPSLGFGMSQKVGHMDFFPNGGKQMPGCKRSSFSTFIDINGIWQGAQDYLACNHLRSFEYYSSSILNPDGFLAYPCDSYDKFQENGCFPCPA... | 128 |
T1EIF3 | 3.5.4.5 | ACT_SITE 50; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | LISSSFSVKENSYCQYSKFRVGCSLLCEDGTIFNGTNVENASYGLTICAERSAICTAVSQGHRKFKAIVVSRCDQDKFTYPCGACRQFIAEFGLDIDVYSTRPDGSYERGTICELLPFSFGQSDVI | 187 |
Q0E8K6 | 5.4.99.12 | ACT_SITE 61; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1" | MYRYLLNISYIGTTFRGIQKTVNKLEQSRLDTKSIQGCLELALQVFHPTNEIHTVLSSRTDAGVHALHSTVQVDLERPNGQPYDTTILTGVLNRTLNKQRLPIRVLSSKLVANSFHCRYDAIGRTYLYRFAVAKVPTLGDCSLRNRSFETFIPVEEIDRCYFLQSSSFDIKRVQAAARMFIGVHDFRTFMSVSRQKVCRDHPMFTVRKIDEINIRPGETRALSSNAIQAAETYNYWDIEIRAKSFLYKQVRRIVGALIALGNGRIDERCLYQMLTVPSKNSWDHRVLLAPACGLYLCRVHYRETDI | 217 |
Q6FN53 | 2.7.11.1 | ACT_SITE 739; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSNANQKENVPSLGLPRTHGTLNVNALKATDILKHKGKLNEVNSDQSTTNENDEVQEEAVFLDDPVHFTRVSSSSELSAALSVNTTEQEQDEEKGTEHAELEPAEEDTVEVDTIRNNGDKTYSTIRESASDFETTNNTLIEISKNSSTYSSTEFLNNNNNGISNSNRATIDSESKLRMNKLREGSSTSLSNDSNGFNGMISSNQASTVLSTPSQKPSSTTNTITKANNGGSTRAQKEKHTSPKLPSTVTAPSSHRKSADLSKTNKLPSTTAKRTPKQAVTSSSPKEPAKRKSSTSKMKGMFSSLVQNMKRNSSDNRKSAS... | 99 |
F4HQM3 | 3.5.1.23 | ACT_SITE 350; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9NR71" | MELSLVRLWNTCFPSFFYISTVLFLLTGGGVYSHSEYLIGLGSYDITGPAADVNMMGYANMEQVASGIHFRLRARTFIVSEPQGKRVVFVNLDACMASQIVKLKVIERLKARYGDLYTEQNVGISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFDALVDGIENSIIQAHENLRPGSIFLNNGELLDAGVNRSPSAYLNNPSKERSKHKYNVDKEMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNSLISGDNKGAASRFMEDWYEQNTAERSYSEEFISDEIPRRVSSLIENHQDSHHELLELASYFESQPGKPVTRISS... | 182 |
A0A2R6X6Q5 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAHTSCVLLLLTVSFLLQKNIDVNGLQDNYYSESCPTAESKIQEAVNTELDKNLKLAAGIIRMQFHDCFVEGCDASVLLDGNNTEKHAPVNEHLTGYEVIDAAKAAVEAVCPGVVSCADIIAYAARDSTLKLNGTGWVVQGGRKDGTVSCADTAEAELPPPTFAVTQLIDSFSKKGLSKRQMVILSGSHTVGVGHCDKFIERLYNFSATNSTDPSLNATYAEQLKQECPQNTFNTTIEIFMDTITPGEFDSNYYKGLTQQKGLFTSDQSLFEDRRTRRIVKSLINERRFDSQFGQAMRALAAVEVKTQGEIRSDCRKVNS | 14 |
Q9EWJ4 | 1.11.1.6 | ACT_SITE 56; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 128; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MTDTPPATTTDSGAPAESDEHSLTAGPAGPVLLQDAYLIEQMAQFNRERIPERQPHAKGSGAFGHFEVTHDVSAYTKAAVFQPGTRTDLVARFSTVAGERGSPDTWRDPRGFAVKFYTSQGNYDMVGNNTPVFFVKDPMKFQHFIRSQKRRADSNLRDHDMQWDFWTLSPESAHQVTWLMGDRGIPRTWRHMNGYTSHTYMWINASGERFWVKYHFKTDQGIEYFTQHEADQMAAADTDYHMRDLFEHIRDGDFPSWTLHVQVMPYEEAAGYRFNPFDLTKVWPHGDYPLIPVGRMTLERNPTDNHAEIEQAAFQPNNLV... | 13 |
A0A2K3D8A4 | 3.4.19.12 | ACT_SITE 14; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 110; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 126; /evidence="ECO:0... | MSLLYHEKQVAALCGVHTLNTLLQGPYFSEIDLAQIAHGLDALERELLGDAMGGEASGNVAMDGMFSIQVLSRALESWGLTVMSLESEEARDLKAAPTSAEAFICNLQEHWFTLRRVADGEWWNFNSLFPAPQPLSTFYLTAFLDTLRGEGWTIFVIRGKLPATQPGGLETLPNAGKWWTSEDARAATDEAERARKRGRVTNALETALARAGEQGGSLQLRTRGTPAAAAAGGDDDEDADLAAAIAASLQQGGAAAGPGPGSQALAVGGGPAASGLGTAAGDAALEQEHGPGLGEFEDEDPELAMAIAASLADQPGPAGA... | 175 |
P35507 | 2.7.11.1 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASSSRPKTDVLVGGRYKLVREIGFGSFGHVYLAIDLTNHEQVAVKLESENTRQPRLLHEKELYNFLQGGVGIPQIRWYGQETDYNVLVMDLLGPSLEDLFNFCSRRFSMKTVLMLADQMISRIEYVHSRNLIHRDIKPDNFLMGTGPQWKKLFLVDFGLAKKYRDNRTGQHIPHRSGKSFIGTPFCASISAHLGIEQSRRDDMESIGYVLMYFNRGSLPWQGLKAATLKQKCEKISEMKMTTPVDVLCKGFPIEFAMYLKYCLRLSFEEAPDYRYLRQLFRLLFRKLSYQHDYAFDWIVLKQKAEQQASSSSGEGQQAQ... | 99 |
Q5BBL3 | 2.7.11.1 | ACT_SITE 686; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNNDSFSSFKFRRPSSKLHKDPPGYGSRALNSQQSTTSLKRHPSAPVYPRSSAAGSREHLRTRSNAYGSSSSSLDQNSAGASPVLGSSDSGHFHSSHSSRSRPPYSGRFSLNDQSSDELIGAPFDSRGMLSALEEHTAEPDNRSYQPPDPAERYTEKPPNFRSQTTPNPRALRQSASFTTLPPRMEAFPNAAGNDRPTNTKRFSDEATPVRPPGPSRSKKSSFSSFVNSMLGSPRGIKISAPENPVHVTHVGYDNQTGQFTGLPKEWQRLLQESGITQKEQEEHPQTMVDIMRFYEKNARGDDEVWHKFDHAYPQQPTAA... | 99 |
A0A1U8ILL6 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPGLTIGDTVPNLEVETTHGTFNLHDYFNNGWTIIFSHPSDFTPVCTTELGKMAAYLPEFEKRGIKLLGFSCDDVQSHKEWIKDVEAYTPGCKVAYPIVADPRREIIKQLNMVDPNERDSSGSELPSRALHIVGSDNKIKLSFLYPATTGRNMDEVMRAVDSLQKTSQYKVATPANWKQGEPVVISPSVPNEEAKKMFPRGFETKNLPSGKDYLRFTNV | 12 |
A0A022QAP4 | 3.1.3.3 | ACT_SITE 89; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 91; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MEGLTIAQIKLKPIHSFSRQHNNTINIPSLGPKVTRKVLFNPARVMRIPKSFNSVSASVQPLEAGRFDNTLPSKEVLEVWGNADAVCFDVDSTVCLDEGIDELAEFCGAGQAVAEWTARAMNGSVPFEQALAARLSLFNPSLSQVQEFLEKRPPRLSPGIDLLVNKLKEKNKIVYLVSGGFRQMINPIASILGIPLENIYANQLLFKSSGDFSGFDTNEPTSRSGGKAIAVQQIRKAKGFKSLVMIGDGATDLEARQPGGADLFVCYGGVQLREPVAAKADWLVYNFKDLINSLD | 147 |
Q7NM67 | 2.7.6.1 | ACT_SITE 213; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MVFPDLLPRRSTVQPVRLMGDERLRLFSGSANPELAQLVARYLGLAPGPLVRKSFADGELYVQIQESIRGCDVYLVQPTCSPVNDSLMELLILIDACRRASARQITAVLPYYGYARADRKTAGRESITAKLVANLITAAGVDRVLAMDLHSAQIQAYFDIPLDHVYGSPVLLQYIKEKQLGDMVIVSPDVGGVSRARAFAKKLDDAPLAIVDKRRQAPNEVEVMNVIGDVKGKTAILVDDMIDTAGTISEAAKVLLRQGAKEVYACATHAVFSSRAIDRLSDGTFTEVLVTNTIPVPPDRRFPQLRVLSVADLIGEAIWR... | 114 |
P40881 | 4.2.1.1 | ACT_SITE 96; /note="Proton donor/acceptor"; /evidence="ECO:0000305|PubMed:10924115"; ACT_SITE 118; /evidence="ECO:0000305|PubMed:10924115" | MMFNKQIFTILILSLSLALAGSGCISEGAEDNVAQEITVDEFSNIRENPVTPWNPEPSAPVIDPTAYIDPQASVIGEVTIGANVMVSPMASIRSDEGMPIFVGDRSNVQDGVVLHALETINEEGEPIEDNIVEVDGKEYAVYIGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGNNCVLEPRSAAIGVTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVVYVNVHLAEGYKETS | 199 |
A0A804KJ98 | 3.1.1.11 | ACT_SITE 474; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNVVNILRLMLLIYLDYHQLDFLCKGLFRLRHFLFHGVPHYIAFIFLSSLLKMAHVGSMSVYERVMMSRNREHKKKLVVWAFAVSLAIALSAGLALKTIKQAGAKPKPLGHSLHSHNVVSRATDTSTAVTESSVASTCKSTLYPEACEAALASVASTASTKEMFDVSVESAKSKARVARDVAYNLTQPSAQKSTSRSQSSVNDCLELLDITLDQLDDVLRAKKSSGFHDVQTWLSAALTNQATCSEGLETVKAKGGDSLNAQVESLSQYISNALALHKKVKAKDKDGHGGRKLLSDRFPEWLSAGDRRLLQASPEDIRAD... | 125 |
A0A6I8PSP5 | 3.1.3.48 | ACT_SITE 97; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MLCGAVELLPGLLLGGAAAARAARAARAGAGVTVTALLTVQEEEEEAAEQEAEEGGLQTLVVPVRDEPRQDLLGSLDRCAAFIGRVRRGGGAVLVHCHAGVSRSVAVVTAFLMKTQQLSFEEAYARVRALRPQAKMNEGFEEQLKLYEAMGCQVDASNPSYKQYRLQKVTEKYPELRNLPREVFAADPDAESPGLREETLYRCRKCRRALFRSSSVLGHPGGSGPAAFAHKRKTPVYPPAAAGPASCTSHFVEPVQWMEAALLGVMEGQLLCPKCGAKLGSFSWCGERCSCGSWVTPAFQVHKNRVDEARALPARVPPAG... | 149 |
A0A0K9PCP2 | 1.11.1.7 | ACT_SITE 90; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNSIIHAYSDPIYNHNSQTNMSVEGRVKQIVAVLVVAVVFAPPAAVSGELVVGFYKNTCPKAEALVQQAVSRAYLTNPGIAPGIIRLLYHDCFVEGCDASVLLDVSADGSALVEKDANISQSLRGFEAIDFAKASVEEECPGVVSCSDILNFAARDSVELTGGITWDVPAGRRDTRISIKDNIHGNFPGILSYKGGVELNGLLKSFTKKGLTPEDMAVLSGAHSLGRSHCLAFIDRLYEDHYSPDSPPLTDPTMSEAYAHLLRRICRPGFLDNNTTTFLDMITPNTLDNKFYLGLLNNLGLLMTDQALTQRRNLMAVVKK... | 14 |
D7THC1 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 122; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 137; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MEGPSNGGMLYHEVQESKLCAVHCVNTVLQGPFFTEIDLAALASDLDLEERRMMLQPSAPSAEFLSEDSHNVSMDGDFSIQVLQKALEVWDLQVIPLDCPVAEPAQIDPELENAFICNLQNHWFCIRKVGGEWYNFDSLIAAPEHLSKFYLSAYLDTLKSSNWSIFLVRGNFPKECPISSFEASNGYGQWLTPEDAERITKSCNSTERPPEISNQNQQHSEPLIPLEEAAEHEDEDLKAAIAASLMDHPAMTNAEADTPSQNENKNIIEKDK | 175 |
A7F9Z4 | 2.1.1.33 | ACT_SITE 176; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MAGPPNKKQKREDYRTARENGEESKELPKKKFYRQRAHANPFSDHRLAYPASPAQMDWASHYPAYAESPTASEGIEETSEVCKSSNVKKMKQDVEVADIGCGFGGLTVALAPKLPNSLILGTSAFCPIERIKALRVQEKETGLFQNASCIRANTMKFMPNFFKKHQLAKIFLCFPDPHFKARKHKARIVSTTLAAEYAYVVRPGGIIYTITDVEDLHNWMVTHFNAHPTFERVLEEEQEADECVNIMRTETEEGKKVTRNNGPKFVALFKRLEDPPW | 45 |
A9UX44 | 6.2.1.5 | ACT_SITE 268; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MASPALLVRTVRTIYDATRPALRINKDTKVICQGFTGKQGTFHSEAAIAYGTQMVGGVSPGKGGREHLDLPVFNSVKEAKDATNADATVIYVPPPFAAAAIFEAMEAEIPLAVCITEGIPQADMVRVKHALVRQDKTRLIGPNCPGIIKPGECKIGIMPGHIHVPGNIGIVSRSGTLTYEAVGQTSAVGLGQSLCVGIGGDPFNGTNFIDCLEVFLNDPETKGIIMIGEIGGSAEEEAAEYLKQHNTVRPVVSFIAGLTAPPGRRMGHAGAIISGGKGGAGAKIAALEDAGVIVSKSPAQMGVLMKQEMEKAGLA | 247 |
Q96RG2 | 2.7.11.1 | ACT_SITE 1128; /note="Proton acceptor" | MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPS... | 99 |
Q2R560 | 2.7.11.1 | ACT_SITE 708; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGRDARRLPLLPFLLLLLAAAAGVAESATDAEAIHDLARSVPALGWDGDNVCGFEGVTCERGGAGKVTELNLADRGLSGTLPDSLSSLTSLTALQLQGNALTGAVPSLARMGSLARLALDGNAFTSLPPDFLHGLTSLQYLTMENLPLPPWPVPDAIANCSSLDTFSASNASISGPFPAVLATLVSLRNLRLSYNNLTGGLPPELSSLIAMESLQLNNQRSDDKLSGPIDVIASMKSLKLLWIQSNKFTGPIPDLNGTQLEAFNVRDNMLTGVVPPSLTGLMSLKNVSLSNNNFQGPKPAFAAIPGQDEDSGNGFCLNTP... | 99 |
Q8NKC2 | 4.2.1.11 | ACT_SITE 212; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 346; /note="Proton acceptor"; /evidence="ECO:0000250" | MTTIQKIYSRSIYDSRGNPTVEVELTTELGTFRSMVPSGASTGEWEAKELRDNDKNKWGGKGVTIAVHNVNNIIGPALVKSDIKITDQRGIDEFMIKLDGTNDKSKLGANSIVGVSMAVARAAAAFLKIPLYEYIGKLAGSKTTECIPVPSFNVLNGGRHAGGDLAFQEFMIMPIKAPTFSEGLRWGSEVYHTLKALAKKKYGASAGNVGDEGGIAPDLTTAEEALDLVNEAIKEAGYDGKVKIGFDVAASELYNGKLYDLDFKSEHPKPENKLDYKKLYEKYSALIEKYPIVFIEDPFSEEDWGAFSYMSSKTKVEVIA... | 200 |
F6HLM9 | 6.3.2.17 | ACT_SITE 1570; /evidence="ECO:0000256|PIRSR:PIRSR604808-1"; ACT_SITE 1610; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR604808-1"; ACT_SITE 1708; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR604808-1" | MAAESVTVSVQRAPFSSKWQASRRDKLHTQVRASQSMDDKNKVFKELGLFSLRKKIEGVVLQADMLAPAALELEEASRIRQEEMIRKYNLWDDVTKSNEILGKLADSSKVVDTLKDLTYKAEEAKLITQLVEMDAINHGLFEQAYNASVDVSKFLYQYEMSKLLRGQFDMEGACLTIKAGPRGIYSEIWAEQLLSMYTKWAEKQGYKGRVVEKYASKNGGIKSATIEFESEYGYGYLSGERGVHHMIRSSDDESILHETGSAVVDVIPLFLETAPDLQIDDGDLRISSPSCHGVEQGRTGHAVCIQHIPTGISVQSSGER... | 249 |
Q5U1S8 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASCSKWLAGLMLLAAALACSLPAASRAQLQVGFYNTSCPTAEALVRQAVVAAVANNSGLAAGLIRLHFHDCFVRGCDASVLIFSPNGTAERDAAPNNPSLRGFEVIDAAKAAVEAACPRTVSCADILAFAARDSVNLTGNSFYQVPAGRRDGNVSIDTDAFTLPGPNLTATQLVDGFKLRNLTAEEMVILSGSHTIGRSHCASFLFKNRERLANGTISPAYQALLEALCPPTTGRFTPITTEIDVSTPATLDNNYYKLLPLNLGLHFSDDQLIRNATLLPFVDAFAANETLWKEKFVAAMIKMGNIDVLTGARGEIRLN... | 14 |
A0A0K9NNI1 | 3.1.1.11 | ACT_SITE 478; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVTISVIKIYPAHLLSSATIHGSLHLPIALKPDPNYPDITNNNLSMETLNSFKGYGKVDVTENAEFRRKTRNRIIVIGISSVLLLLIVVGVAAGVVVTRRGYGGRSKTPTLPAVNISESIRSICAVTQYPDVCYSSMMEAVAADDDSDRRKGNYDAEQFFKISLQIAQGGFQRISQLPEQIAATVNDTRVKDALGVCTEMIDDSIDSLEESLDLLKPTPGQNTLTHFKIGSLRTYLSAVITNSYTCVDGFQDTKGNFGDKLQTSLRNSTQFASNSLAIVTKLLLVLEKSGIPLHRKLLATETMPYWVQSNSYARRLLQTS... | 125 |
A2BVI1 | 2.2.1.2 | ACT_SITE 135; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MKSILEQLSSITTVVADTGDLDAIKKFQPRDATTNPSLILAAAKNPDYVKLIDQSLESSRKSLPNGVSESELIKEAIDQVSVFFGKEILNLISGRVSTEVDARLSFDTDATVKKARKLINHYKSFGIDKERILIKIASTWEGIKAAEILEKEGIRCNLTLLFNFCQAVACANAKITLISPFVGRILDWHKVKTGKDNFSGKEDPGVISVTKIYNYFKEKGFKTEVMGASFRNVDEIKELAGCDLLTIAPKFLDELSKEEGELIKKLDENIQSKSSIDYEFDEKDFRLSMLEDQMASEKLSEGITGFSKAIEELEELLLKR... | 52 |
A0A2K2BQS4 | 2.3.1.181 | ACT_SITE 178; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MIFPRSLEVWKLGKVNYLEALKLQEKLVCDRKAYKIPDTLLSLQHPPTYTLGKRRTDHNLLIPVPELEKIGAELHYTQRGGDITYHGPHQAILYPIISLRDIGLGARKYVEKLELTMIDMASQYGVKACAGKKCETGVWVGDRKIGAIGVRISSGITSHGLAFNVDPDLDYFKHIVPCGIADKEVTSLRRETGMGALIFHGNKAYKKELHMLNSKAIRILTSLYRTFTALRGFGTLMSDSWLKKRTGALDGRIIL | 55 |
P45683 | 2.1.1.77 | ACT_SITE 60; /evidence="ECO:0000250" | MTSQRTRERLIQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLLAAGPLDKVMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQSLLDQLAPGGRLVIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLLNGPIA | 49 |
P9WK13 | 1.1.1.37 | ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01517" | MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADER... | 5 |
F1A4P6 | 3.4.19.9 | ACT_SITE 137; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 253; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 253; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MNKIIVLFIYFFLFLNFLKTNCLKQDGCHHALNDRPVIGILSQPASSDKYKEYGYQYIAASYVKYVESAGARVVPILYDQDEDTLRKLLNSINGILLPGGGVYFDEQPIYNKSLYLIWNYVIESNKRGDYFPLWGTCLGFEEIVSVAANTFDVLTSFNASNYSIPLNLTDQVLNLSSNSLLFKEMPLEMLKTISNEPITMNNHRMGLSVETFNNFTSLHQFFDILSLNDDKSGNTFISVIESKEYPIYAVMFHPEKPLFEWYEKEDI | 176 |
A0A058ZYU5 | 3.1.1.11 | ACT_SITE 228; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MANKLEFRGLPPLAIAILSLLIALAQIAVSDDKIPIPADKSQVNAWFQQNVQAFEARKGTLDPNLEAAEAIPPKVIRVSQDGSGDFKTVTEAINSIPAGNSQRVIVSIAGGVYKEKITIERTKPFVTLYGSPNDMPKLTYSGTAQQYGTVDSASIIVESDYFVGANLIIENSAPRPDGKAAGGQAVALRTSGDKAAFYNCRMLGFQDTLCDDRGFHFFKDCYIEGTVDFIFGSGTSIYLNTELRVLGDSGLSVITAQARQSNTEDTGYSLVHCSITGTGNGTFLGRAWMPSPRVIFSYTDMSSVINPLGWSDNFHPERQR... | 125 |
Q8EXX3 | 3.1.26.3 | ACT_SITE 66; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 138; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MSFKKAQSHFFLKNPERVRSLQKLSKKIGIKFSKVEYYNTAFIHSSYKNENQEILEDNERLEFLGDSVLGLVAARSLFRKYPKANEGELSRIKSRIVSTPILNSISEKLELSEYLLLGKGEKNSLGKGRRKLSANLFESLVGAIYLDQGFEIAEKFILRHLSEFVENPEKEESVRDYKTQLQEYSQKHFKILPIYRTKSESGPDHAKTFQVVVRIRDQWEASGSGVSKKSAEQNAAKELYNRIRKKT | 138 |
A0A5G2R0L1 | 2.3.2.26 | ACT_SITE 1232; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAHRLRFHFGSGRSNTAPESEILDQEREDDFFMAFHTLPRRSGPHPFASHGAEDGGGGLQAGVGALKRSSSMFIPQLLSPVDTRPTRSSSVQISLQRKAADGAPDGCGPPEGLDGDAGSVPRSGCSETPEPKSLENPSPGAARAPGPQVNGTCGRRAPGLTAPDGREEAKPSIAQGPEGSGGLRIQHRASSADVRQVRLTPFGADGPSSSSAQEPRRWSLQHVPDASGSSGKRCFVFQLQQPQPGVPGLGGDFNFGFTGTKGDRLVRYPRIRLERSTSYPTQPRAERGSPTEEHGHPETPPRGRRVAPEIHRTNSVERTP... | 65 |
P56137 | 6.3.4.4 | ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 40; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MADVVVGIQWGDEGKGKIVDRIAKDYDFVVRYQGGHNAGHTIVHKGVKHSLHLMPSGVLYPKCKNIISSAVVVSVKDLCEEISAFEDLENRLFVSDRAHVILPYHAKKDAFKEKSQNIGTTKKGIGPCYEDKMARSGIRMGDLLDDKILEEKLNAHFKAIEPFKKAYDLGENYEKDLMGYFKTYAPKICPFIKDTTSMLIEANQKGEKILLEGAQGTLLDIDLGTYPFVTSSNTTSASACVSTGLNPKAINEVIGITKAYSTRVGNGPFPSEDTTPMGDHLRTKGAEFGTTTKRPRRCGWLDLVALKYACALNGCTQLAL... | 253 |
A0A1Y1HXB9 | 6.2.1.5 | ACT_SITE 279; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MFGSRGLAGLIKHAVRGIEASRTYASSTGKPAVFVDKSTRVICQGITGKNGTFHTEQAIDYGTKMVGGVNPKKGGTEHLGLPIFKSVQEAKAETQCDASVIYVPPPFAAAAIMEAIEAELDLVVCITEGIPQHDMVRVKAALLKQNKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRVGIVSRSGTLTYEAVFQTTQVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGQAEEDAADFIKESGTTKPIVSFIAGLTAPPGRRMGHAGAIIAGGKGTATDKIKALESAGVTVSRSPAKLGTTMLQLF... | 247 |
A0A1D8PQT9 | 2.7.11.1 | ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MPETSITSDLEHRQQDEISSISSIYGDIFKDITPTGLVWNKKPSPHFQVFLSSSNNPDRPTVSITLDIEFTPTYPLSPPKVKLLNARNLLKINIAKLEKKCKDLIKEYPEQEVSFTIISELIFMLDEIQTTTEKVLSLEEERELRLRNERRALEEKEAKQKKDEELARKKQNKELNEQIQKIQGEFDDDFTDDQDLDMSTTNDNNNSLIPLDKDQFFIFENAMEATIPNTRRKFKFRAISGFIRYNQKGVFNSIGSQYIVKPFIDNEIRNKIENKGSDLAFLLTVIDLTNEYWQTDKGKREIQDLESELQSIMSINHSNI... | 99 |
A0A2I4GRR4 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAGFTSFSSVLLISSLLLVSYAFAAEVKSSVPIVKGLSWSFYDSKCPKLESIVRKQLKKVFKEDIGQAAGLLRLHFHDCFVQGCDASVLLDGSASGPSEQDAPPNLTLRAKAFEIINDLRDLVHDKCGRVVSCADITALAARDSVFLSGGPDYAVPLGRRDGLNFATQEVTLANLPPPTSTTSDLLANLSSKNFDATDIVALSGGHTIGVGHCAGFTGRLYPTQDSTMDKTFAKDLKEICPALDSNGSTVLDIRSPNKFDNKYYVDLMNRQGLFTSDQDLYTDKRTRDIVTSFAVDEGLFFEKFVDFMTKMGQLSVLTGT... | 14 |
Q8L4H4 | 2.7.11.1 | ACT_SITE 722; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MMELQVIRIFRLVVAFVLCLCIFIRSASSATKGFESIACCADSNYTDPKTTLTYTTDHIWFSDKRSCRQIPEILFSHRSNKNVRKFEIYEGKRCYNLPTVKDQVYLIRGIFPFDSLNSSFYVSIGVTELGELRSSRLEDLEIEGVFRATKDYIDFCLLKEDVNPFISQIELRPLPEEYLHGFGTSVLKLISRNNLGDTNDDIRFPDDQNDRIWKRKETSTPTSALPLSFNVSNVDLKDSVTPPLQVLQTALTHPERLEFVHDGLETDDYEYSVFLHFLELNGTVRAGQRVFDIYLNNEIKKEKFDVLAGGSKNSYTALNI... | 99 |
P47355 | 2.7.11.1 | ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEAILKIGDIVENKYQIEKLLNRGGMDSYLFLAKNLNLKNYGPVQKKQYGHLVLKVVQKNPKINENNWKKFLDEMVTTTRVHHSNLVKSFDVVNPFLKIVRGNKTIALNQIVMIAMEYVDGPSLRQLLNRKGYFSVSEVVYYFTKIVKAIDYLHSFKHQIIHRDLKPENILFTSDLTDIKLLDFGIASTVVKVAEKTEVLTDENSLFGTVSYMIPDVLESTVNKAGKKVRKPPNAQYDIYSLGIILFEMLVGRVPFNKSINPNKERETIQKARNFDLPLMQATRSDIPNSLENIAFRCTAVKRENNKWLYSSTKELLEDL... | 99 |
Q6H7T7 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASTRRRRAGGVPMAVIRLGVAAIVVLGAGVIGGARAQLRMGFYDESCPAAERIVGEYVRQHVGRVPTVAAALLRLHYHDCFVRGCDASILLNSTGNGGAAEKDAAPNQTLRGFDLIDRVKGLVEAACPGVVSCADVLALAARDAVAAIGGPSWRVPTGRRDGTVSSMQEALAEIPSPAMSFPELAGLFATKGLSVRDLVWLSGAHTIGIAHCSSFADRLYNGGGGAGNANGNNTDPPPLDAAYAANLRERKCRTAGDGVVEMDPGSHLTFDLGYYRAVLRHRGLLRSDAALVTDAAARADIAGAVASPPEVFFQVFGRS... | 14 |
Q04933 | 1.8.1.4 | ACT_SITE 458; /note="Proton acceptor"; /evidence="ECO:0000250" | MFRRCFPIFNPYDVVVVGGGPGGYVAAIKAAQLGLKTACVEKRGALGGTCLNVGCIPSKALLHATHMYHDAHANFERYGLMGGAGVTMDVAKMQQQKEKSVNGLTSGVEYLLKKNKVTYYKGEAGFVTPNTLNVKGIDGKDEAIEAKNTIIATGSEPTALPFLPFDEKVVLSSTGALALQQVPKKMVVIGGGVIGLELGSVWARLGSDVTVVEFAPRCAPTLDSDVTDALVGALKRNGEDEVPMTGIEGVNGTNNGSIALTLEVEQAGGQAETLHCDALLVSVGRRPYTAGLGLEKNNVSLNERGFVKIGSHFETNVAGV... | 36 |
A0A3B5ZVU6 | 3.2.1.14 | ACT_SITE 89; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MARFAALAALLLAVAVGGAAAQGVGSVITQSMYASMLPNRDNSLCPARGFYTYDAFIAAANTFPGFGTTGSADDVKRELAAFFGQTSHETTGTSVRQSISQSVSVDFGAALINRSACLCMPCQRVGGTRGAADQFQWGYCFKEEINKATSPPYYGRGPIQLTGQSNYDLAGRAIGKDLVSNPDLVSTDAVVSFRTAMWFWMTAQGNKPSSHDVALGRWTPTAADTAAGRVPGYGVITNIINGGLECGMGRNDANVDRIGYYMRYCGMLGTATGGNLECYTQRNFAS | 158 |
A2G690 | 2.3.1.48 | ACT_SITE 272; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MSETTRFKKNDYVIAKTDDFPDGAQGEIIDFRRHDTQAYIHFINQDKRLDRWVDIGTLRLNPDQINVNSKNKKSHDNSDEEQPELIKFEEVHKEITKIRNIDMITIGNYTMRTWYFSPFPYPYFEMDHIYMCEHCFTYFASEKDLQDHIHKLNETHPPGREIYRDGNLSIYELKGKNQKIPCQNLCLLSKLFLDHKTLFYDVEGFEFYVLCECDNSGSHLAAYFSREIKSSQGNILACITTLPPFQKKGYGHLLISLAYELAKRQKRSGGPETPLSDLDKIAFKTYWRYAIVNALKKGENQISSIDDIVVETAIDRKDII... | 61 |
Q8YAR1 | 6.3.4.4 | ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MSSVVVVGTQWGDEGKGKITDFLSENAEAIARYQGGNNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGMVVDPKALVEELKYLHDKGVDTSNLRISNRAHIILPYHIRIDEADEERKGANKIGTTKKGIGPAYMDKAARVGIRIIDLLDKETFKEKLEHNLGEKNRLLERFYELEGFKLEDILDEYYEYGQQFKEYVCDTSVVLNDALDDGKRVLFEGAQGVMLDIDQGTYPFVTSSNPIAGGVTIGSGVGPSKINHVVGVAKAYTTRVGDGPFPTELFDSIGDTIREVGHEYGTTTGRPRRVGWFDSVVVRHARRV... | 253 |
I1GW87 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAARSAMLTLLLSAILAVGGAAAAKAESSGKLRQGFYSHSCPRAEQLVARYARRHVPRSPSLAATLLRTHFHDCFVRGCDASVLLNGRKKNNGEAEKEAAPNLTLRGFAFLDGAKALVEEECPGVVSCADVLALAARDAVAAIGGPFWKVPTGRRDGRVSRKQEALDQIPAPTMNFTALLASFRSKGLELPDLVWLSGAHTIGIAHCDSFGERLYNFTGRGGAGDADPSLDTAYAATLRRTKCATPTDNTTIVEMDPGSFLTFDLGYYRGLLKRRGLFQSDAALITDAAARADVESVAKGPPEVFFQVFARSMVRLGMVG... | 14 |
A0A9J7L7P6 | 2.7.11.13 | ACT_SITE 534; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MWKKGKSKGVSSASGVPGVSGAMSVLALGGPGFIRVKLLQVDPGSLEVPPGETFDPYCAVNVKEAVDTPGRGLQLIQKKKTIYPEWNSCFDSHLYQGRVIQLAVMAKPMNKLLAEVSIGVQMLAEKCQKGDDKIISTWLDLKPSGRLLVQVRYFSEEGQGAARGTPEEEEQYGAFTRRRMAMRKAKVHVIKGHEFIAKFFPSPTYCSVCKEFLWGFNKQGYQCGACSAAVHKKCHSHVLGKCPKTAIVSQESKFLKERFNIDVPHRFKTNNYMSLTFCDHCGSLLVGLFRQGVKCETCGMNCHHKCQAKVANLCGVNQKL... | 100 |
B3RL12 | 2.7.11.1 | ACT_SITE 586; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MTWKNLVRVPEIDIENAKGLSDSQMEELKEQLNNLAKERIGYEVLYELAEFVRGYLHKYNRPQLSFYALMVKQQEDEKKKKNLEEFQESDEIIQTRIDGDKEEIRRRGNKIKFKVMGEERNIQIGKLTGKTDFGYYKFAGIDCNTGDIISLLAWQLKPIKSDNNSLLRQIIELEQEVNSRLPPSHPNIIGFLGVNHVISNDYIQIQVLSEHIPISSLADRIGNNRGLDLEELRYYTRQIMEALQFLHNKKIYHGYLTASCVHVDSAGEIKLSNYELSERFHSLSEDFAGATGSVYSVSDDIFRLGVLLLSLYKGQQVRAT... | 99 |
Q4WB57 | 3.2.1.22 | ACT_SITE 484; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005536-1"; ACT_SITE 546; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005536-1" | MAQKSTTANAIVVEGKTFALNGYNVSYRFHVDESTGDLRSDHFGGSVSGPIPDDSAPIMNGWTGMPDRVRREFPDQGRGDFRIPAIRIRQSQGHTVSAFRYDSHTVLKGKPALAGLPATFGTEEDVSTLVVHLYDQHSEVAADLMYSIFPKHDAIVRSVRITNKGEGTISIEALSSMSVDLPCEDFDMIGLRGDWAREAHRRRRKVDYGIQGFGSTTGFSSHLHNPFVALAHRSTTESHGEAWGFSLVYTGSFAANIEKGSQGLTRVSMGFHPNQLSWPLAPGEIFTSPECVSVYSKDGLGGMSRSLHRLYRNHLMKSKF... | 162 |
A0D0J4 | 3.2.1.143 | ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 167; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MKCQEKFKNTTLPFMIESVQQLLQQKPQIQLLLQNQSLALSRKTVFSLLSLMYFELTIQQSVQNFKFPQYFSFSTYYLQGSQLEKLKCLINYFNQCVDSPEYFNLPEIVYQRNSLVDVPNWINSQLPLSDFKFEKKKNEDHLNCGIVDFSDRYFGGKVAAGRGCVQEEVLLLINPEAIIASLFTSQLGDKESLIISGILQFNQYRGYEDSFVCIPAKYQNKGQTLIAIDAIYFATKPQGYQFTQEAIFRELNKSFSGFQGSQQQIISTGKWGCGIYGGDKQLKTLIQWISFSQACPNGTIIFNGLDDKAYNDQGKRLELC... | 159 |
B9IDR8 | 3.1.1.11 | ACT_SITE 441; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDYGRLGPTESDPGEGSGTSFNINEPQLATPRVSPTRKKRIIFLAIFSIALIAASAVSAVLLLGIRTKASGQPDPSSLTHRKPTQAISKTCSKTRFPNLCVSSLLDFPGSVSASESDLVHISFNMTLQHFSKALYLSSAISYVNMETRVRSAFDDCLELLDDSIDALSRSLSTVAPSHGGGTGGGSPADVVTWLSAALTNQDTCSEGFDGVNGAVKNQMTGRLKDLTELVSNCLAIFSSANGDDFSGVPVQNKRRLLTENEDISYEENFPRWLGRRDRKLLDVPVPAIHADIIVSGDGNGTCKTISEAIKKAPEYSTRRT... | 125 |
A0A072U3Z0 | 3.1.1.11 | ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFHNFFILTLCFSLSLSILASLPSSSLADNSKVPPQTICESTVNPPFCKTLLANQNGTVIDYGRFSIRKSLSQSRKFLNLVLSYLQDKSSLSQPTISALKDCQFLAQQNFEFLSNTHQTANKTSNVLPISQGEELQTLLSAVLTNQQTCLDGLVTASSDQTVINDFSSTISDDTKIHSVSLALFLKGWVGDKKKQTSWPQNGRHLNFHNGHLPFKMSDKVRAIYDSARNRHGRKLLQTIDESVTVSEIVIVNQDGSGNFTTINDAINVAPNNTVASSGYFLIFVTEGIYQEYVSIPKNKKYLMMVGDGINRTIITGDHN... | 125 |
A0A061G110 | 3.1.1.11 | ACT_SITE 442; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGYDRLRPSEPGGSGLPQLQQLPHEEPRAKNHKKKLLIVSVVALAMIIISAVCAGLVIGLRKGGADPVGTQIRRKPTQAMSRTCSKTRFPNLCVNSLLDFPGSLTANEEDLVHISFNMTLQHFSKALYTTTSISYVQMDPRVRSAYDDCLELLEDSIDALSRSLFSVVPSQDGNANNNNVKAGTNQDVMTWLSAALTNQDTCSEGFEGVSGAVKDQVAEKMKDLSELVSNCLSIFAASGGDDFAGVPIQNRRLLATDDDISGEIIDDENFPKWLGRKERELLDTPVSTIQADIIVSKDGNGTVKTITEAIKKAPEYSARR... | 125 |
Q9P3U0 | 3.4.19.12 | ACT_SITE 623; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 1076; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MATVKNLRIGKSPNRLIQDLDVFDSPSAGWNDPWSPHSSRYHWQLHSNLGESAVFDENDFWCVCQKTRKHLHVKVRRDRGKPLIEEPEENYGIKDRIPVYYEEEELPEPHVTSPTKSEFATTSTCMKWSSKTTKSEIEVEWRDSYLDANCIKEIIDSRRPSFASLLTKKSSSHQGSSHSSQPSLFTTFTSLELFLRNVLVHNDQRAISAAPEGTFERHVGKGRQIQSLMKSLLFEYHHENVNYVPTIADAPLTDEQKLNLYLARNELIVLANHFRDTKEDPAIVANPFPVRLARPALINAFGVPNYDSVVPMYTTVFRDN... | 175 |
Q9V6K3 | 2.7.10.1 | ACT_SITE 580; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MAAGQWVGVVERVLRGMVLKWGANLAVLGLCVFLFASATHANSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTP... | 97 |
A0A3Q7GME6 | 3.1.1.11 | ACT_SITE 389; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGVNKVAIGSIASLLLVACVVAAAISTTSKRNEDNSSNNNNDSQISTSAKSVNVICQQTDYKETCVKSLAKANNTNDPKDLLKVAFGATINDLFDVIKNSALLINEASKDPRTKDALKTCGDLLDVAIDDVRRSFDEIGVFDATKFKDYADDLKTWLSASITYQETCLDAFENTTGETGEKMRKLLKNAGELTSNSLAMVSSFGQVLTDLNLKIPGVNRRLLNAHERMLNEVNSNGLKPNVVVAIDGSGQYKSINEALRAVPKKNTQKFVIFIKAGIYKEYIDIPKKMNHIVFIGEGPTKTKITGNKNFADGIGTFQTAT... | 125 |
F0ZPS5 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTKLKVGDTAPSFKDIPDGKGNLHSLENYAGKILVLYFYPKSFTPGCTKQACEFRDKYEAFSEAGAVVIGVSSDSQDSQSKFQDKYRLPFPILSDNKGELAKLYGVEKELLILPGRTTFIIDKDQKIAHTYTNMFKATSHIDESLKIIEKLK | 12 |
A0A078H8E6 | 3.1.3.48 | ACT_SITE 136; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MQKLDLIRENLYLGDICAAAEVLKNGSSEISHVLTVLHCPSISVFEEWRSVRLDSKEIKEVYVGDDDHQGREFATESALPSGNLLYSLEHTGKDLKFTRMAVFAYDNEWENLLDFFDICLDFIDAGRKEKGVLVHCFAGESRSASMVIAYLMRTEKLSCQDALASLKQSAHARPNLGFLKQLDLFERMNFKVDRSSSIYKHFRLKALGYLYSKDKRFDKLKLKDDQGMLNEGSGSTYQCKKCRNVLLLQKQVIDHTPGEADLEFDDMFKNMMGEVHNKNPGDQKKCTSIFVEPLSWMNEAVEDDLPEGKLLCPKCKARLG... | 149 |
A9UVY3 | 3.5.1.2 | ACT_SITE 85; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 193; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 195; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MAAPSVTIGVLALQGAFREHLRALSEFEGVSALPVRTKEQLATVDALVIPGGESTTMGLVAERSGLLEELRAMTRARQKPVFATCAGLIMLAQRAQHEKTGGQPLLGGLDVVVDRNFFGTQLQSFEATMDVRLPGDEAASTCHAVFIRAPAILEVGIRVEVLATLPVDKSPRPLEKPCIVAARQGPFLVTAFHPELTADRRWHAYFVDQVRATKG | 181 |
H3GWS1 | 2.7.11.1 | ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 223; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MKHEDDFRLSKAAENQLARTLRNEESGRSRHTGRDDRATTEQVLDPRTRMILYKMLNHGIVTEINGCLSTGKEANVYHARLPDGREGAIKVYKTSILVFKDREKYVSGEFRFRHGYSKSNPRKMVKLWAEKEMRNLRRLRDSGIFCPAPILLRSHVLLMDFIGHDGWAAPRLKDAKISDIRYRECYLYCIKMMRVMYQKCRLVHGDLSEYNILYYQTKLFFIDVSQSVEHEHPSANDFLRKDCRNIADYFRKTGALNPMTTQELFDFVTDPRIADDDVDEHLEAIQRVIAERPVERTNQEQVDEAVFMSTFIPRSLGEVL... | 99 |
A0A2K1L722 | 3.1.1.11 | ACT_SITE 249; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEKKAPRRDAACVVVIMYMTAVLVFCSPGLVQGRSPLKNRALKSDIKVPATKDEVAAEFLSWVASVVTDYENKTSSQTNSPSRLPNLGIKAEPPIYYVDQAGYGNFRTVQEAVNAVPEGNSMRVIILVKPGIYRERVNIPKSKGYITLQGSGKESTSIDYNENAASAGSTYDSATVAVFSDYFVARDISFRNSAPAPPSGAVNMQAVALRITGDCAAFYGCGFYGSQDTLNDDMGRHYYKNCEIVGSIDFIFGDAQSLYKDCALNVNAATYGSVTAQKRESSSRRTGFSFVGGSLLGSGQVYLGRAWGPYSRVVFAFTFM... | 125 |
A0A1Y3BU91 | 3.4.21.92 | ACT_SITE 101; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 126; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MHLGLTYSATCACTVPKGYNLTLINRLYRERLLFLGQEVDSEISNQLIGLMIYLSIEDDTQDLYLFINSPGGWVIPGVALYDTMQFVQPDVHTICMGSAASMGSFILVGGEITKRLAFPHAWVMIHQPAGSFSEVATGEFILEVGELLKLRETLTRVYVQRTGKPVWVVSEDMERDVFMSATEAQAYGIVDLVAVE | 179 |
A0A1U7ZU14 | 3.1.1.11 | ACT_SITE 228; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAGKVTSSTAVKALLLILLIVIEVPSTALSQGETEIDRWIQKHIQAYVARKEELREGVDTALEPALKAAEASRRVIKVRKNGAGDFRTVTEAISTIPAGNTKRTIVWIGPGVFEEKIKVNRSQPFVTFFALPKDKPTLVYHGTAKDYGTVDSASVIVESDYFMAVNIIFKNSAPEPDGKREGAQAVAMRISGDMAAFYGCSFIGFQDTLCDDKGRHFFKDCYIEGTVDYIFGNGKSIYLNTELHSVSNRTAFITAQARERVDDDSGYSFIHCKITGNGETYLGRAWKDRGRVVYAYTYMGTHVKAEGWSNFGVASRDKTV... | 125 |
B8C6L3 | 2.3.1.286 | ACT_SITE 125; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | LESIAESFKRGRYKKVLVVSGAGVSCSAGIPDFRTAGSGLYDNLHKFNLPYPEAIFDVDFYKSGPMPFVTLASEIWPGVKYRPTLTHCFFNLLDKKGTLSRIYTQNIDGLESVAGVDDNKMVECHGHFKSSSCIACKTPHDAESCKSSMLEKREAPICNNCGSLVKPDIVFFGEMMPTRFSERVHYDVASADLIIVLGTSLLVAPVANIPDWVPSNVTRLLINRDLVGTFSEAKSTDVFMEGDCDESVRKLCEMIGWCDELDQMYKDCRSDNESK | 58 |
A0A8M1N5Y4 | 5.3.4.1 | ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9H3N1"; ACT_SITE 51; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9H3N1" | MANMRNIILTALLSAIALVSGYVEGLDDKFTEFRQNELWLVEFYAPWCAYCHTFEPVWTEVGAELKSLGSPVNVGKIDTTAHTSIATEFNIRGYPTIKLFKGDLSFDYKGPRTKDGIIEFTNRVSGPVVRPLSSVQLFQHVMSRHDVIFVYIGGESLLKKEYYKAATEFIVHTYFFTASEEILPKAVTLQDVPAVAVFKDGTYYIYNEFIDGDLSSWINRERFLSYFQIDSYSLYQMGELSKLVALAVVDEKNPSEESIRYKTLMERVSTEYRDHYKSDFQFGYVDGNEYVNGLIMGELAMPSIIVLNMSIDGYYIPESS... | 215 |
Q83CY8 | 1.11.1.24 | ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P0AE52" | MSIEVGQKAPIFTLPTDEGEMLSLDDLKGKKVILYFYPKDDTPGCTKEACGFRDVWSQLSKAGVVVLGISKDSVKAHQSFKQKYNLPFTLLSDKDNTVCEQYGVMVDKNRFGKKYKGIERTTFLIDEEGVISAVWPKVKVDGHVAEVVGRL | 12 |
A0A059DDI5 | 1.11.1.7 | ACT_SITE 92; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAPREPSSHRRKQDKKPKEMATGSFRHYGLGFVLLSLLLQLLSVTCTGSSELQSNYYAESCPNAEEIIKQEVAKLYDEHGNTAISWIRNLFHDCMVQSCDASLLLESKHGNGIVSEQASSRSFGMRNFKYVTKIKEALEKECPATVSCADIIALSARDGTVLLGGPRIEMRSGRRDGRESHASVVEEFIPNHNDSMALVLSRFESVGIDAEGTVALLGAHSVGRVHCVNLYDRLYPTVDPTLDSDYAEYLKGRCPMPDPNPEKVRYSRNDRETPMVLDNMYYKHLLAHKGLLLVDQQLASDPTTAPFVEKMAADNGYFQD... | 14 |
Q8P4D7 | 3.2.2.27 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148" | MTEGEGRIQLEPSWKARVGEWLLQPQMQELSAFLRQRKAANARVFPPGPQIFAAFDATPFEQVKVVVLGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIPRPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGKVIDQARHRVFKAPHPSPLSAHRGFLGCKHFSKTNEHLQRRGLSPIDWSLPSRAALDLSLAGG | 173 |
Q9P3U4 | 2.3.2.31 | ACT_SITE 304; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MSDLLDDEFYEEEFENDLLDASEFEDEFDEDAEIDDDGFTVERKRRRAHSVSYRVVSVRDLRASLNEKINQLTSIIDLTREQVLGLYRYFKWNRERLLERYIDAPEESLQKAGVGLSGSKQREVVHHEGTCEICYDEGCLPFFSAECDHEFCLACYRQYLDSRISEGESVIQCPEESCTQIVSIQSITKVLDEKSLDRYHRLLDRSFVDDNDHLRWCPAPDCEFAIECHVTQASLSSVVPTVTCNCGKQFCFGCGHDNHQPTICPLVKIWLQKCQDDSETANWIHANTKECPKCSTTIEKNGGCNHMTCKKCKYEFCWVC... | 67 |
A0A067DHC8 | 3.4.19.9 | ACT_SITE 159; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | PRNCLWIPILLCLFNELSFAEAESSTILLPSQQHNADSVSTTFCAHCPAPDPSLNYRPVIGILSHPGDGASGRLSNATNASYISASYVKFAESGGARVIPLIFNEPEEILFEKLELVNGILYTGGWAKSGLYYDIVEKIFKKILEKNDAGDHFPVYAICLGFELLSMIVSEDRNILETFDRANQASTLQFVKNINIEGTLFQRFPPELLKKLSTDCLVMQNHHVRKLCFMYG | 176 |
Q8REF0 | 3.5.1.88 | ACT_SITE 134; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MVYKIKKYGEDVLKQIAKEVELSEINDEFRQFLDDMVETMYETDGVGLAAPQIGVSKRIFVCDDGNGVLRKVINPIIVPLTEETQEFEEGCLSVPGIYKKVERPKRVLLKYLNEYGKEVEEIAENFLAVVVQHENDHLDGILFIEKISPMAKRLIAKKLANIKKETKRIKEENE | 183 |
Q4PHZ2 | 3.1.1.3 | ACT_SITE 319; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037" | MRASTHSWLLLVVVLSLSSFTVNAVILEGLIPPRSHLAPSTFQQPFALSSYLQKLFGTSLRALYGAEQNRQTSVKTFGLREAYHQGIGDKAHERARATFDFRITANDVQADQANIDFIPAIRTVRQRITRAKDPKKYVEVRGQSYRDAMCAASTELDWEDVDVEAPDVTERTTVLAFAKMASAAYKNDTSDWDGIGGFDPTNSFGWEGDGIRGHIFTTHDNDTIVVALKGTSNVFLGGGDTARRDKTNDNLLFSCCCARVSWSWSTVCDCYQGHGDQCGQTCVERALIEKSLYYPAITDLFNNVSYAYPDSQIWITGHSL... | 128 |
A0A9R1UQ98 | 3.1.1.11 | ACT_SITE 369; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASINFISSCCLYVFILSSSFNLLIQATEESGGDINWWCQTTPHPNQCNYFLGRGRGHHTPPKHRADFRMRVLQAAIDNANEAQGCAKNLGEMCSTTVTKAVWNDCYQLLNNTISQLNQTVIGLKNNRSSDFDAQTWLSAALTNLQTCFTGCVELNVTDLVTPIRSSNLTEMISNSLAINHLFLKQKSSSDQTDDFPGWVTRHDRRLLTTATIQSIANVTVSKAAGSRFPTIQSALDYAGSIERLNQRFIIYIKSGVYNENILIGSDFNNIMFVGDGIRYTIISGNRSVAGGSTTYSSATVGVDGSGFFARGITFRNTAG... | 125 |
A0A8J1LUD8 | 3.1.3.48 | ACT_SITE 1033; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1" | MGGNLAIFAPPTRTPPQSEAGGNSSPRAGVPDPSYGLVDRFITHRTGTASTLSPHCPVLSAESPAASTIRTEPLAGTAAAHASCPGAFCCVTESHTSLSGPTAPFSPPHSHWVLGLCYSQYEAPFVTAGVASLDNPWELKDYSGTRTPLVSPDQEPSSSQLTAELGPYMKVKDLVWTVMTARFRLPAGRTYNVRASEQARDRQSTEVVCNILLLDNSVQTFHVNKHNHGQVLLDLVFKFLDLTERDYFGLQLADDSCDNPRWLDLNKPIRKQLKRGSPHNLNFRVKFFVSDPSKLQEEYTRYQYFLQIKQDVLTGRLPCP... | 149 |
A0A072VQE6 | 2.3.1.181 | ACT_SITE 178; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MRALRTLEVWKMGVVNYLDALKLQEKLVLDRKSHKRCDTLLSLQHPPTYTVGKRQTVHNLLIPQSELEQIGAELHYTQRGGDITFHGPHQAILYPIISLRDTGLGARKFVEKIESTMIELAGLYGVKACPGKKCETGVWVGERKIGAIGVRISNAITSHGLAFNIDPDLNYFRHIVPCGIADKEVTSLRRETDFDLPTEEIIQEQLVSCFARIFGYDNLIWKEDASISSDKNETE | 55 |
P70424 | 2.7.10.1 | ACT_SITE 846; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNN... | 97 |
A7EM74 | 2.7.11.1 | ACT_SITE 333; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 350; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MADSAETSTSISAVAAGQDPTHTYIPNQGYVRPATSDAPPMTPTSGENTEYAADNEDDAYDDLFDEEDDGYVDDVDYDPSSGDLTKSYNRQRKLNDSNATGAPRINPQRPAANTKASVDDQISSLSKHAAKIRLDGGFDGGHKTHGKDKSDRATSEQVLDPRTRMILLQMINRGIVSEVNGCLSTGKEANVYGALSIPSADADSQPIHRAIKVYKTSILVFKDRDRYVTGEHRFRSGYNKGNNRAMVKVWAEKEFRNLKRLHLAGIPCPEPVHLRLHVLVMGFLGDKKGWAAPRLRDVELSGEDVDEQWRLLYLQLIGLM... | 99 |
C5XIY2 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEAARSYFFVAAVAVVLIALLPASAIAAGLKVGFYNKSCPSAEALVQQAVAAAFKNDSGIAAGLIRLHFHDCFVRGCDGSVLIDSTANNTAEKDAPPNNPSLRGFEVIDAAKAAIEAQCPKTVSCADILAFAARDSVALSSSSASGSGKNLTYKVPAGRRDGRVSRDTDANSNLPSPLSTAAELVGNFTRKNLTAEDMVVLSGAHTVGRSHCSSFTNRLYGFSNGSDVDPAISSAYAFLLRSICPSNTTRFFPPNTTTDMDLITPAVLDNKYYVGLTNNLGLFTSDQALLTNATLKKSVDEFVKSDSKWKSKFAKSMVKM... | 14 |
W5N625 | 2.7.11.1 | ACT_SITE 1788; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR629601-1" | MSQKSWIENTFTKRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHAGFTASLAMKYSDVKLGENEMPELEEWSVEKHTEESPTDAYGIINFQGGSHSYRAKYARLSYDSKPEMVLRLLLKEWQMELPKIVISVHGGIQNFDLHPRIKQVIGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHSSRSSRKICTIGIAPWGVIENRNDLIGRDVIAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVKLRRELEKHINLQRIHARIGQGVPVVALIFEGGPNVVLTVLEYLQESPPVPVVVCEGTGR... | 99 |
Q9GRT1 | 2.7.12.2 | ACT_SITE 196; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MPPKRPQALEKLHVEPHDKGVSITDTMTLVVKGEGGVEMRVKQTGIAQGPGSSSAGGQPKSDAVMNKIKFEDLRIGSELGKGSQGKVRVAQHKLTGEKYAMKYIAFDGDSDDMRSALEAELRQVAAVKHHNVVSSYEAFFRDGRLYIVLEYMDCGTMNNLIDRHPEGFSEDMLAYIARELFKGLEFLHHLNMIHRDIKPANVLANTKGEIKISDFGVAKTLSGGDLQTLSAQGSVPYMSPERIQSKPYSFNSDIWSAGLTIAECAFREYPFASLKPKLFELCQAIASGTAKINWDDRETKFSDEFKEFIELCLRPEATRP... | 108 |
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