Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
P39745 | 2.7.11.24 | ACT_SITE 220; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPTWIPNNLCAQPTTRNAKPPSNGHPQATQQQSAPGSLAYRNSSNIPNGATNHVRQQKWQYTRSGHRKMADGEAVISTVNNVEEVHGQLFEVAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSN... | 104 |
M4CZ74 | 2.4.1.18 | ACT_SITE 487; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 542; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MVVVHGVSLTPGVLVSSFLPLPLSSSNARSLNSTVSFFLKKRPLSRKIFAGNQSAKFDSKSQAVSKKVLVPDNVDDGASLVTDDALQGPSSVSEESQILNLESQTMEEDGIVITEDQASVSVNSSKVVKEKEVKPRTVPPPGNGQIIYEIDPMLRSYKDHLDYRYKQYKRLREEIDKYEGGLEAFSRGYEKLGFLRSDAGITYREWAPGAKSASLIGDFNNWNPNADIMTRNEFGVWEIFLPNNTDGSPAIPHGSRVKIRMDTPSGIKDSIPAWIKFSVQAPGEIPFNGIYYDPPEEEKYVFKHPQPKRPKSLRIYESHV... | 73 |
H9GIE2 | 3.1.4.11 | ACT_SITE 339; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 384; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MCELYKYVKRIITSPSLQIPRRGLRGRQLFQLASYSLEKKCMSSMQAGTQMIKLRGSSKGLVRFYYLDEHKSCIRWRPSRKNEKAKISIDSIQEVCEGKQSEIFQRYADGSFDPNCCFSIYYGDHMESLDLVSSSGEEARTWITGLKYLMAGISDEDITSLFPFLNSCQMWLKQTFDEADKNGDGSLSISEVLQLMHKLNVNLPRQKVKQMFKEADTDDNQGTLDFEEFCAFYKMMSTRRDLYLLMLSYSNHKDYLDVDDLRRFLDAEQKMSNVTKDHCLEIINQFEPCPENRQQGALGIDGFTNYMRSPAGDIFNPEHY... | 153 |
A0A2I4EPV3 | 2.1.1.37 | ACT_SITE 1244; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MALAVDESGRPFMAIKEQEQKTGLGGLDAQKAKTSSGMKKKKSTISSTKKAATTSQKEKKRNVSQGSEEPTGSRKMPKRASACRDFKERSIRICEKSCVVETKKDQFADEEILAVRLTSRQDDGRPNRRLTDFVLHDENGAPQPLEMLEVDDMYISGLILPLEASLEKEKDKEKGVRCEGFGRIESWDISGYEDGSPVVWLSTDIADYDCLKPASSYKKFFDHFFEKARACVEVYKKLRRSSGGNSDSSLDELLAGVVRSMSGSKHFSYATSIKDFVISQGEFIYNQLVGLDETSKKNDLIFAEMPVLAALRDESSKRGS... | 47 |
Q4WV24 | 2.4.1.18 | ACT_SITE 348; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 403; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MASTEASNIAQSAPPDGTGVIQLDPWLEPFRDALRHRFGLVENWIKTINENEGGLDKFSKGYEKFGFNVNANGDITYREWAPNAVRAYLVGDFNNWDVAAHPMAKDNFGVWEITVPSKDGMPAIPHDSKVKIAMDIPSGERIYRIPAWIKRVVQDLEVSPIYESVFWNPPESEQYKFKHSRPRKPESLRIYEAHVGISSPETRVATYKEFTKNMLPRIKYLGYNAIQLMAIMEHAYYASFGYQVNNFFAASSRYGTPDELKELIDTAHSMGLTVLLDVVHSHASKNVDDGLNMFDGTDHLYFHEGGKGRHDLWDSRLFNY... | 73 |
B7P620 | 1.3.5.1 | ACT_SITE 287; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | QFTGSYEVVDHTFDAVVVGAGGAGLRAASGLVEAGFKTACITKLFPTRSHTVAAQGGINAALGNMEPDDWRWHIVRVQIQARSGECCEVLYWEAAGLFGCTRRGFHFFRTQEGKIYQRAFGGQSYNFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSFNCNFFVEYFAMDLLMENGECRGVLALSMEDGTLHRFRAKNTVLATGGYGRTFFSCTSAHTCTGDGNAMVTRAGLPLQDMEFIQFHPTGIYGAGCLITEGCRGEGGFLINSEGERFMERYAPVAKDLASRDVVSRAMTIEIREGRGCGPDKDYVYLQLHHLPP... | 28 |
A0A0A0K9M0 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRASNPIISVLLFTTLLALQVVNGALVNNFYRRTCPQAERIVQDVTFRLVRSNPRLGAQLLRLQFHDCFVRGCDASILLDTVGTNQSEKEARPNLSLLGFNEIDQIKSEVEKACSGVVSCADILALAARDAVSFPFKNRPRWPVLTGRRDGTISRSSEVSGNIPSPFSDFATLKQIFENKRLNVIDLVILSGGHTLGEAHCGTFSRRLYNFTGKGDADPSLDPRYADFLRTKCPNPADPSITVEMDPRSSRSFDSNYFKILTQHKGLFQSDAALLNDTSSSRLVRSLQNPKVFSFSFASSMLKMAAIEVLTGNNNGEIRK... | 14 |
P52987 | 1.2.1.12 | ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MVVKVGINGFGRIGRLALRRIQEVEGVEVAHINDLTDPAMLAHLLKYDTTQGRFKGTVEVKEDGFDVNGKFVKVTAERNPEDIQWADSGVEIVLEATGFFATKEKAEKHLHPGGAKKVLITAPGGNDVKTVVFNTNHTILDGTETVISAGSCTTNSLAPMADALNKNFGVKGGTMTTVHSYTGDQMTLDGPHRGGDFRRARAAAENIVPASSGAAKAIGLVLPELSGLMKGHAQRVSTPTGSITELVTVLEKHVTVDEINEAMKAAADESFGYNVDEIVSSDIIGMAYGSLFDATLTEVTDLKDGGQLVKTAAWYDNEMS... | 22 |
F6V6I0 | 3.4.19.12 | ACT_SITE 806; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093" | MAEDLGELLVPYMPTIRVPKSGDRVYKTECAFSYDSPESDGGLYVCMSTFLGFGREHVERHYRKTGQSVYMHLKRHIRLKATGASGGAFPKRINGRLFLDLENNTEMNTEDYEYEDEAKLVIFPDHFEIALPNIEELPALVTIACDAVLNSKSPYRKLDQESWEEELQVSKFANNLVQIDNGVKIPPSGWKCSKCDLQENLWLNLTDGSIMCGRWFCSGSGGNGHALEHHKQMGYPLAVRLGSITPDGADVYSFDEEEAVIDPHLAKHLAHFGIDMLQMQGSENGVLDNEVKPRVNEWEVIQETGLKLKPMFGSGYTGIK... | 175 |
A0A059BQT6 | 1.11.1.6 | ACT_SITE 157; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 230; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MAGEPNKAAIPCFFPSFACKQLMGEDTLEWHNDEDNDERRERSYITHALPGSLSPSSSSSSVSKPSSSTSSITLASSADPRRLSVVSRPPTAMDPYKYRPSSAHDSSFWTTNSGAPVWNNNASLTVGTRGPVLLEDYHLLEKIANFDRERIPERVVHARGASAKGFFEVTHDISQLTCADFLRAPGVQTPVIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNFPVFFVRDGMKFPDMVHALKPNPKSHIQENWRIVDFFSHHPESLHMFSFLFDDVGVPQDYRHMEGFGVNTYTLLNESGKAHYVKFHWKP... | 13 |
Q54GE6 | 1.1.1.37 | ACT_SITE 244; /note="Proton acceptor"; /evidence="ECO:0000250" | MEQAILRINNISSQLTGKCPFKAHGGGAGKCPYKLGGGQILDQSKAWSLVNVTANVDQVTPIKVLVTGAAGQIAYSLMFMIASGQMFGPHQPVILHLLDIPKMADALKGVVMELQDCSYPLLQSVVATTDIQTAFLHINVAILVGAFPRGPGMQRKDLLKVNVSIFKEQGEALNKYASRGVKVLVVGNPANTNALTALMKASDLPTSNFSALTRLDQNRAQSMISEKVGTNVDNVHNVIIWGNHSQTQVPDVNHGYILNYPNRGLIEPIPSSVNDDKWLNEQFIPLVQNRGATVIAARKLSSAASAANAIVGHVRDWLLG... | 5 |
E3K8B9 | 6.3.4.4 | ACT_SITE 17; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 45; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 156; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MAIEPCVDVILGAQWGDEGKGKLCDILSAKVDICARSAGGNNAGHTIVVDLPPGQGINGKGGKTKYDFHLLPSGLVNQDCIGLIGSGTVVHVPSFFDELASLESKGLKCSDRVLISDRAHLVFDFHQIVDGLKEIELGGSSIGTTKKGIGPAYSTKASRSGLRVHHLMGDFANFEQKLRSLVNGRRKRYGEFEFDIEAEVARYRGYAERLKPFVVDGVLYLHNALTSTDAPKRVLVEGANALMLDLDFGTYPYVTSSSASIGGVLTGLGLPPRAISEIYGVVKAYTTRVGSGPFPTELTGKWGEHLQEAGAEWGTTTGRR... | 253 |
C4LY26 | 2.7.11.1 | ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MAAPRRFAQLSVNSPLKKEIESKPKKDDEKKPTQLSLDMFDVGKPLGQGKFGNVYLVKYKKYDYVCALKVIFKRQLQKCGMGIQMKREIELQSHLNHPNILKLFGFFEDKNRWFLVLEYCKKGELYGLLQQAGRFDERRAARYIKATTEALKYCQEMNCIHRDLKPENIMIDHNDQVKLADFGWSVHTNTKRNTYCGTLDYLCPEIVLEKYYDGSIDQWCLGVLTFELCTGEPPFQSNSREEVMKKVRNVKYSFPSYLTNDCKDFINKLIQYDPSKRMIMEKQWENYQILHSKDVILEDSHDWTLNTLLRGLDISFSTNH... | 99 |
A0A9R0IJU3 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRLGSLSSMLPLGFVLMTFISHCYGHDLRVGFYDGKCGGQDIEKLIYGIVKKKIAKDPDVVSDLTRLLFHDCFVRGCDGSILLKGNHTEQKAHINKHVAGMDDIDDIKKAVEKVCPGVVSCTDVLVMAARDAGFLAGGKRYDVETGRRDGRVSSSKEAEASLPPPTIPVNKAIQMFAKNGLNEREFVVLLGGHTVGTAHCNSFKNRLYNFNNTQKPDPTINSALLPLLCKTCPLHSQSENETFLDHNPTSHFKMDNDYYKQIVAHNGTLEIDQNLAINPLTRGIVEELANSPDQFLNEFGPAMVKMARIGVLTGDRGEIR... | 14 |
A7TB56 | 3.2.1.52 | ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | TKISDTPRFLWRGLLIDAARHFQPVDVIKRNLEALAAVKMNVFHWHLTDDQGFRIESKVYPKLHELASDGLYYTQHQIKDVVKYAARLGIRVIPEIDVPGHATAILTAYPELGSKDKYTYTLQRNAGIFDPTLNPTIDKTYEFLENLFAEVTSLFPDEYFHIGGDENEGKHWSENKKMTAFKKKHNLKTNHDLQTYFNIKLEKILSKFGKKLMGWDEIMTKNMPTTAVIHSWRGTTEGLKESTLIEAAKKGYQSVLSNGYYIDRMQSVVHHYKVDPIGNAKLTPAQRARVLGGEATMWGELVTPLTIDSRIWPRTAAIAE... | 170 |
P17514 | 3.2.1.14 | ACT_SITE 92; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MEFSGSPMALFCCVFFLFLTGSLAQGIGSIVTSDLFNEMLKNRNDGRCPANGFYTYDAFIAAANSFPGFGTTGDDTARRKEIAAFFGQTSHETTGGSLSAEPFTGGYCFVRQNDQSDRYYGRGPIQLTNRNNYEKAGTAIGQELVNNPDLVATDATISFKTAIWFWMTPQDNKPSSHDVIIGRWTPSAADQAANRVPGYGVITNIINGGIECGIGRNDAVEDRIGYYRRYCGMLNVAPGENLDCYNQRNFGQG | 158 |
A0A059BWD9 | 3.2.1.1 | ACT_SITE 192; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 217; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGNSNNGHVDDNQHTDVGAIIQSGREILFQGFNWESHKHDWWRNLERKVTDIAKSGFTSMWLPPATNSFSPEGYLPQNLHSLNSAYGSEHLLKTLLQKMKQHKVRAMADIVINHRIGTTQGHGGMYNRYDGIPMAWTEHAVTSCTGGLGSKSTGDNFNGVPNIDHTQEFVRKDLLGWMQWLRKVGFQDFRFDFARGYSPKYVKEYIESAKPLFSVGEYWDSCNYSGTTLEYNQDSHRQRIVNWIDGTGQLSAAFDFTTKGILQEAVKGQFWRLRDPKGKPPGVMGWWPSRAVTFLDNHDTGSTQAHWPFPSNHIMEGYTY... | 157 |
A0A078JNC6 | 3.1.1.11 | ACT_SITE 342; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGITDMVLFGLLLVNALLPVDASGRMPFTYQNQLQRHCSSTEYTSLCVQTLREFRHESTTSLDFVSFLVNKTISGSSNLIPPLSSSMASYEVISLDDSTNTLPSPSVADSCERLMKMSTRRLQQAMEALNGSSRKRTTKHDVQTWLSAAMTFQQSCKDSVLDSGGHSSSAVSHITQKMDHLSRLVSNSLALVGTFMENPKPTVLPRWVSAGERKLLASRTSRSRPHVLVAKDGSGDYRTVMEAITLIGEGKDLTVIVGDDSAAGGTSVPDTATMTVTGDGFIARDIGIKNTAGPRGKQAIALSITSDQSVLYRCSISGYQ... | 125 |
P60720 | 2.3.1.181 | ACT_SITE 169; /note="Acyl-thioester intermediate" | MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA | 55 |
F1NJG2 | 3.2.2.27 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166" | MIGQKTLHCFFSTAPPRKRSRSPEPGGDAEVTDDAAKRPKTSDHEAGRASALSPEQLERMRRNKEVALRRLNERSVPPGFGESWRRQLAAEFTKPYFVELMAFVAEERKRYTVYPPPEQVFTWTQMCDIRDVKVVILGQDPYHGPNQAHGLCFSVQKPVPPPPSLENIYKELSTDIEDFTHPGHGDLTGWAKQGVLLLNAVLTVRAHQATSHKEKGWEQFTDVVVSWLNKNLHGVVFMLWGAYAQKKGSSIDRKRHHVLQTVHPSPFSVNRGFFGCRHFSKTNELLKKSGKKPIDWRAL | 173 |
Q0V6S2 | 3.1.3.1 | ACT_SITE 213; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MKCFCSIAAVAALAAGVSAQTFRRLGACPTLDFLAGQFFDVRLEVHQPRNGSEFIGLPLDERFTFTVAKKGAAAKPATEYFKLEEPELEKWNFTFYEDLFARDAKKPTLVNVAAKAYRRVALYEPGEYTATLNYNNGSKTEATWNVRSLEQERKAKNIILFIGDGMTTNMITAARLIGHKTINGKYQTTMAMDKFPVLGHQMTHSIDSFITDSANSAAALNTGHKSTVNCLNVYADSSPSPYDDPKVETIAEMFHRLTGGHIGIVSTAFIADATPAALVAHTRARSTYGQIVDTFLNGLQNYTWTNVPIDVIFGGGAEQF... | 141 |
A0A0R4ILA2 | 2.7.10.1 | ACT_SITE 653; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MTAGVRGMACWGLCGFLFGLLRISSACPVSCFCNASRISCIDQEPGIEDFPVLMPESDMENITDIYISNQKRLFTINEDHMKFYSNLRNLTVTNTHLTYVSTMAFFNNSKLQYLNLGDNNLSTLSWMAMRNSNVSTLLLSGNPLQCACENIWIKLWLDDSERDVLQCLQEGGKAKTLSRLTLPLCEHPRVEVFPTDVSQMAGSDATVICNASGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPNDNGRKLICSAENIVGQIEATVMLNISFPPTVLELYLPERSQDWCIPFVVTGNPRPDLHWYHEGKPL... | 97 |
Q8Y7K7 | 3.4.21.89 | ACT_SITE 49; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 90; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MTDQNEKKPKKKSGAHQLLSWVLVIVAALAIALVIRNFVVAPVKVEGTSMVPTYQDGDRIFIEKISKPDRFDIIVFDEPPMIGSGEHFIKRVIGMPGDKVAFKNGELYLNGKRKVESYLPEGTLTLWNPDPTQKPYIADYTLEDMTGESTVPKGKLFVLGDNRGGSSDSRVFGFIDDSMVNGTVIQFGK | 178 |
A0A1U8MSP9 | 3.1.1.11 | ACT_SITE 231; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSFQVAIEEIRKVLANSATIQDLNKDDNNKAALKVCKEVLDLSIADLQLSFDKLGGYEMSKIGDYILNLRVWLSGGVTPNVVVAKDGSGKYDTITKALAEVPPKSPNRFIIHIKAGTYKEQVLLPKEMTNVMLIGDGPTKTIITNDLNCIRDHPLKTFGTATVGVDGDGFMARDIGFENTAGPPGHQAVAFRETCDMVIMFNCHFNGYQDTLYAHKQKQFYRDCLISGTVDFIFGDAASIFQNCLIIARKPGENQNNMITAHGRKFPYTHSAIVLQNCTISGAPDYLPVKDKSKTYLGRPWKALARTIIMQSNIDDIITP... | 125 |
A0A8I3PHB7 | 1.1.1.37 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MLSALARPAGAALHRSFSTSAQNNAKAAVLGASGGIGQPLALLLKSSPLASLAADLSHIETRATVKGHLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNASVVATLTAACAQHCPEAMICVISNPGLDPARVNVPVIGGHAGKTIVPLISQCTPKVDLPQDQLTAVTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQEADCAYFSTPLLLGKKGIEKNLGIGKISPFEEKMIAEAIPELKPSIKKGEEFVKNMK | 5 |
A0A2G3A973 | 3.1.1.11 | ACT_SITE 386; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATSTEPLLNSTKTKTFSFKSLYIFIAVAAAVCSIAIISIALFNGSIDNSFLSTKSPIGSEVATQTSAKTNNVEMLQMILQKTSSQIQETTTLIENVRLRINDIKEESALRICSELMDLSRDKITDTMVALGKLMTTTSSNSIYFDAHTWLSAVLTNHNTCLDELHGHEAHSIIQSSLSDLMSKASASLSLMVSIAPKTTYHDDLIQPLRGDFPAWVSPKDREILEANPELLKINANVVVAKDGSGKYKTVKEAIASAPVNRNSRYVIYIKKGDYKENIVIDKNKRNIMLLGDGLKDTIITGNLNYASGTGTYDTPTIAS... | 125 |
Q8Y7B5 | 1.8.1.4 | ACT_SITE 454; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAKEYDVVILGGGTGGYVAAIQAAKNGQKVAVVEKGKVGGTCLHRGCIPTKALLRSAEVLQTVKKASEFGISVEGTAGINFLQAQERKQAIVDQLEKGIHQLFKQGKIDLFVGTGTILGPSIFSPTAGTISVEFEDGSENEMLIPKNLIIATGSKPRTLSGLTIDEEHVLSSDGALNLETLPKSIIIVGGGVIGMEWASMMHDFGVEVTVLEYADRILPTEDKEVAKELARLYKKKKLNMHTSAEVQAASYKKTDTGVEIKAIIKGEEQTFTADKILVSVGRSANTENIGLQNTDIATENGFIQVNDFYQTKESHIYAIG... | 36 |
Q812F3 | 3.2.1.35 | ACT_SITE 147; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q08169" | MRVLYFKHSFFRSLLKSNGLPQTLLVFLLIPCYLTVDFRAPPLIPDVPFLWAWNAPTESCFTRFNQPLDLGLFSLVGSPRKSATGQPVTIFYSDRLGLYPYIDDSQLIFNGGLPQLVSLKSHLEVAKTDILHYMPIDNVGLAVIDWEEWRPTWARNWKPKDIYRNKSIELVQQQNILLNFTEAVKWAKEEFEEAARHFMEETLRLGKSLRPNHLWGFYLFPDCYNNKFQVADYKGECPDIEKHRNDALFWIWEESTALYPSIYLKSSLKSSPQAALYVRNRVQEAIRVSKVKDPRNPLPIFVYFRIVFTDLTYQYLYEDD... | 166 |
Q54EM1 | 2.7.11.1 | ACT_SITE 610; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MESKKNSYYKNVMDKIYAKEKDVLSINKDFQENNLTRISLILNYKDFYLKFDESLHGYSFGYVTNLFGLKLYSPFTETVRFDDTEKYMKTILGVPSNEALPQLCSDQHQNFEEKDPQIEILPSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLTPPPSPPLLPIPQPPAQNEEQQLTQPPSIPPPQQKQIKIQKSDRGTQVKSITNPVNSLSKYINNSSLDYSIKKNYTLEEIYENNKNYMDKTNNFLHFLFTFIDKTTIKDLEHFEKEISRVHNIEKLINEQNVKGETPLHSLILYNSESCLKKLVIAKIN... | 99 |
A0A8I6WLB4 | 1.11.1.7 | ACT_SITE 94; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAGSDKKLASLALLLALLGCLGRTCQASHGFPYPLLPFFPVRILPFSVPSLTCGHYPKVKYACDDAEKIVRDIVEEEVYRDRGIGAGLIRLFFHDCFVRGCDASVLLDQTATPNEPTEKDGIPNRGSLRGFEVIDRIKEKLEATPGCKHVVSCADIVAFAARDATYFLSNKVIDFQMPSGRYDGNMSLASETLPNLPPPFADSAQLEAMFKNKGLTLDEMVTLSGAHSIGISHCSSFNGDRPTAMNSTLADLVTAKCSSGGNPTVDQDIRTPRDLDNQYFKNVINHEVLFKSDAALESSTTIESVKQNAKYPLLWEEKFR... | 14 |
A0A9J7KIT6 | 3.2.1.52 | ACT_SITE 339; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MRPYLVLLVALSLQAAVAEWSYQTSWYEKARQDKVARGTVWPQPRSIDTTSVRYYLDPRNFRLEADSSSAAVSDPECKAVVDHALSRYGELLFWIPEEDRAGVDGDETLDKLVLTITRGCTRYPSLESDESYSILVNSDGATLLAQTAWGALRGLETFSQLIYGENGKHVINGTSISDSPRFPHRGIMIDTARHYLPLPFILRHLDAMAYNKMNVLHWHIVDDQAFPFQSTTFPDLSGKGAYTRKHVYTPDDVSQVLEFARLRGIRVIPEFDTPGHMMSWGQGHPEILTRCYPTSFQPDIYYLGPANPARETTYTFMRKL... | 170 |
A0A8J0UWU0 | 5.3.1.8 | ACT_SITE 301; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MHSLFVPNNVFLLSCAVQDYAWGKLGNDSEVARLWSRGDKERPVVPDKPYAELWMGAHPKGDAIITDNQIAQKTLGKWIAAHPECLGTKVREIFHNQLPFLFKVLSVRLALSIQAHPDKALAKRLHTEFPQHYPDDNHKPEMAIALTPFRGLCGFRPIPEIVGFLKAVPEFHTLIGKEAAEKLETSVTGLSEGVEVRKALKNCFTSMMQSNKKDCAEQLNLLVQRVSQQFKSGKDVSSCLGDLLLTLHSQFPGDIGCFAVYFLNVLTLQPGEAMFLGANEPHAYLEGDCIECMACSDNTVRAGLTPKFIDVQTLCEMLTY... | 214 |
W5N181 | 2.7.7.7 | ACT_SITE 317; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MEARGIVKAFRKVKRIGHQLEKEEEPQNKKQQKELVTGTWLNGICAYIIQTGIGNARATIFQTQIVQNGGQVVDTFSPCVTHVIVDDSMNYDRALRLLKVDKLPPAVQLVKCSWLSLCITEKKLLNTAGYSVFIPDRNLDSNHEQVKVNSLNGNGSALGIHVQQTNNKQKTEKEATVSKTVQIEESASLNTIISSHRAQTSDDDGSDTEEAGVSQKDLEALLTGCYPTTEEPSPAQPDPVTGKWVCAQSSKAKNDNHNQHITDKLEVLAKAYTHQGDKWRALGYSKAINALKSYHKPVSSYEEACKIRGIGKRMAEKIKE... | 121 |
A0A072U6W2 | 1.1.1.8 | ACT_SITE 231; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MAPALEVQGVENVSQNNGLNNVDDVTNRSKVTVIGSGNWGSVASKLIASNTIRMNNFHDEVRMWVYEETLPSGEKLTDVINQTNENVKYLPGIKLGKNVVADPDLENAVRDANMLVFVTPHQFMEGICKRIAGKIRADAEAISLVKGMEVKMEGPCMISTLISEELGINCSVLMGANIANEIAVEKFSEATVGYRQNREAAERWVHLFYTPYFIVTAVQDVEGVELCGTLKNVVAIAAGFVDGLEMGNNTKAAIMRLGLREMKAFSKLLFPSVKDSTFFESCGVADLITTCLGGRNRKVAEAYAKNGGKRSFDELEAEML... | 7 |
Q9KPS5 | 2.7.7.7 | ACT_SITE 108; /evidence="ECO:0000255|HAMAP-Rule:MF_01113" | MQDRIRKIIHVDMDCFFAAVEMRDNPAYREIALAVGGHEKQRGVISTCNYQARKFGVRSAMPTAQALKLCPQLHVVPGRMSVYKSVSQQIQTIFQRYTSLIEPLSLDEAYLDVSESTAYQGSATLIAQAIRRDIWQELNLTASAGVAPIKFLAKVASDLNKPDGLYVVTPDKVQEMVDSLPLEKIPGVGKVALEKLHQAGLYVGADVRRADYRKLLHQFGRLGASLWKKSHGIDEREVVTERERKSVGVEYTFSQNISTFQECWQVIEQKLYPELDARLSRAHPQRGIIKQGIKVKFADFQQTTIEHVHPALELDYFHEL... | 121 |
A0A1U8KXK4 | 2.3.2.26 | ACT_SITE 1874; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAEASSAAPSSSPSGPTTRSHKRARLSSSSSPAAATTTTPRSRTSRAAAALMDSTTTESSSGSRRDRRPSKANQTTTSDSPNLASDRGKEKERDPSACDRDRDRDRDRDRDRDNRDNNSNNPERNLGLIMDTSGGDDDDNDSEGGVGILHQNLTSASSALQGLLRKLGAGLDDLLPSSAMGSASSSHQSGRLKKILSGLRADGEEGKQVEALTQLCEMLSIGTEESLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCFCARLLTIEYMDLAEQSLQALKKISQEHPTAC... | 65 |
Q86KC1 | 3.2.1.17 | ACT_SITE 24; /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"; ACT_SITE 112; /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"; ACT_SITE 114; /evidence="ECO:0000255|PROSITE-ProRule:PRU01252" | MRFIALLISFFALLKVISAISGVDISSASTIESFTCLKSAGYDFAIIRAYESLGQVDPNGPHSVYNARDAGIEYVDVYMFPCPTCGNGAGQAETMVNYLKGYNANYGMVWLDIEGPQYWMSQSENVAFFESLVAGLKAEGAHIGVYTSASQWEPIMGGYTGGSEFPLWYAHYDGNPSFSDFSPFNGWSTPSVKQYDDTGDSCGLGFDLNWYP | 160 |
Q75KK8 | 2.7.11.24 | ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDFFTEYGEGNRYKIEEVIGKGSYGVVCSALDTHTGDKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLRGLKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFSDTPTAIFWTDYIATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAELLTGKPLFPGKNVVHQLDIITDLLGTPSPETISRIRNEKARRYLNSMRRKKPIPFTQKFPNADPLAMRLLERMLAFDPKDRPSAEEALADPYFKNIANVDREPSAQPIT... | 104 |
A0A3B6LV08 | 2.1.1.37 | ACT_SITE 1187; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MSNSPYSAGTAGTKRRQAKPKSDNENIIEESNVTTNIGHDTIGCKRTKREVARSNFNEKAFDLLEEDSLVTTKEIRTEEEAEAVRLTRTGPEDGKCCRKLIDFILHGKDDNLQPFEMSQSDGVSMTALVMPFDAHIEKDRKKGIRCVKFGRIKGWAVSGYKEGAAVISLSTELADYICVKATRSYRSHFDLFSQKAHVCVEVYRELARSVGGNPLLSLEELLAGVVSSINLSSGFNGRVRKEFVISIGEFVHNQLTALDHAANNDDEMLLTLPALVALRNECKSNVGFSKLAALASHETLMIKDGRCKEVQVTENEDEEE... | 47 |
Q17770 | 5.3.4.1 | ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 55; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 393; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 396; /note="Nucleophile"; /evidence="ECO:0000250" | MFRLVGLFFLVLGASAAVIEEEENVIVLTKDNFDEVINGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDIKLGKLDATVHGEVSSKFEVRGYPTLKLFRNGKPQEYNGGRDHDSIIAWLKKKTGPVAKPLADADAVKELQESADVVVIGYFKDTTSDDAKTFLEVAAGIDDVPFGISTEDAVKSEIELKGEGIVLFKKFDDGRVAFDEKLTQDGLKTWIQANRLALVSEFTQETASVIFGGEIKSHNLLFVSKESSEFAKLEQEFKNAAKQFKGKVLFVYINTDVEENARIMEFFGLKKDELPAIRLISLEEDM... | 215 |
A0A1Y1I114 | 3.4.21.92 | ACT_SITE 204; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 229; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MASSVVRGVAAGAAGVAASAPSRTQQVEHRQMPCTLSTPFRGAALKTKSLAVNRKASQKARSIVAAAEGFRSPGLMSEQGYPGLSGAASPITSISNIETPYSALMGDIRADGQGPPPGMVERFQGVISQLFQHRIIRCGGAVDDDMANIIVAQLLYLDAADPGKDIIMYVNSPGGSVTAGMAIFDTMRHIRCDVSTVCVGLAASMGAFLLSGGTKGKRYALPNARIMIHQPLGGAQGQQTDVEIQANEILHHKANLNGYLAYHTGQPLEKIVSDTDRDFFMSSKEAMEYGLIDGVISNPLKALTPTPTPTPTPTPA | 179 |
Q09448 | 3.1.3.2 | ACT_SITE 33; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000250" | MFLSLFCVIIVAVGCSSKDGNVKLEFVQAMWRHGERSALADLYPIYEKDWVFGGGGLGELTGRGMGEMNNLGRLIRERYVRKFNFLEPKYASKEVYFRSTNLNRTIISAMSLLYGLFPPSLYDIPNVDYPFTPLKWLPGLAFVPVHVDGSDQCAASQNCPCPRYDFLQQQMLTLPEVQQAFQQVILLNRQIAPLYNVTTGVDTFYVYPDTWKCQRAYFNKTMYDKLPWYNEQLYSKAEITYAPIKGFLEGSFSQPAVTSNGLDVAFEIQQVRSGVMINEIVSRASEKLNCVERGQNCTSYLNKLKFYGYSIHDNNVYAVL... | 145 |
Q03221 | 2.7.1.21 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLIDGKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK | 88 |
F6SUA6 | 4.1.1.17 | ACT_SITE 359; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MKQDCSVETSAVEIYPTINTSEIIASKILNDGREDHDNGFFICDLGDVMKKYIRWQKNFPRVIPHYAIKCNPDEILLKMLIGLGTGFDCASKSEIRQMLALGARPEQIIFANPCKQASHVRYARDNNVKRIVFDNVEELIKMKKNFPTADLVLRIQTDDSQSICRFSMKYGAHPDVCKQLLDTAHKMNLNVVGISFHVGSGCQDVQAFVKALQNARVLFDYAECIGYKLNLLDIGGGFPGTEDVNLKFEEIASVVNMTLKELFPMEEFPHVDVIAEPGRYFAASAYTLASNIIAKREVMRDVTEETVCEQTAYMYYINDG... | 195 |
A0A251RLF1 | 3.1.1.11 | ACT_SITE 318; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLKTYLILFYSIISLIFFTSCEVSRRDQTPFTELCNHIMGPEFESRDFGIKAMHKTRETLERFLAMPHTMLDVQAKTSLMDCLELYKNVINHLNLSKKHTNAADVRRWLIAAVVNHQTCLNGFKHSNLLRLFEDMLVELEASNSHSPTIHNHGFVQLSEGCAIQANFVVAQDGSGDFSTVTEAIEAAENQRRIVTNRLVIYVKAGIYKENIYIKNSMTNLMLYGDGIDATVITNDKNIFDGLLTSNTATVQVWGQGFVAHGITFENTAGPEKQQAIALLSASDQSIFYKCSFKGNQDTLCLLQNRQFLRECDIYGTIDFI... | 125 |
A0A8M2B825 | 2.1.1.37 | ACT_SITE 809; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MAKQSPKQEAEQEVCEVSKEEKVTDTPTRRVGRPARKRKAPAVNSCEVVTKSSGCVKQSECNGEADSRVAKKSLQRNDSSPESSHQNGADTPPGEDSAPSTPRKKRGRRKLERTERDIEEDDTSSDTSRGESDGARHRGRQGWDISLRRRPVQRETFQAGDPYHISRREKEELLAHWKKEKEKKVRLVQMSDTMDHQSAVGSQEDEPAMILPTIPIGGSRDKAGKKFEKKVRLVQMSDTMDHQSAVGSQEDEPAMILPTIPIGGSRDKAGKKFEKKVRLVQMSDTMDHQSAVGSQEDEPAMILPTIPQQQQKKVRLVLMS... | 47 |
Q97Z86 | 2.7.6.1 | ACT_SITE 188; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQDKHLIELFLIAETIRDLGAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIEDPFILAPDRGALDRARKIAEEINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGAKSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL | 114 |
B8E001 | 2.7.1.21 | ACT_SITE 90; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MEIVSGASGWIEVICGGMYSGKSEELIRRVRRAQIAKQKVQVFKHSLDIRYDKDYVASHTGLKIEAIPVSSSADIERLVKDDTQVVAIEEGQFFDMGLVKVCQRLADRGKRVIVAGLDQDFRGEPFGPMPYLMAVAEYVDKLHAICMKCGNVASRTQRIIDGKPAYYDDPIILVGAFETYEARCRHCHVVLRREEDEK | 88 |
Q54K56 | 3.2.1.52 | ACT_SITE 357; /note="Proton donor"; /evidence="ECO:0000250" | MKLKFIFLILFFIIGNSIGIKISKEINKIKLNDISIDGEILLNKSSDSSSSQSSKIINIWPMPKKVLNGDITVYISPHFQFTTNLTKSTTLKKAMDRYYKLIFTEDSKSHSGISILNEIKILVKSEDETLQIGFDESYEIYIDDSGDDGGKIIAETVYGAIRGLETLYQMIGFDYQREYYQIKHCPWIIQDSPRYPHRGVMLDTSRHFYSVDVLKEFIEALAYNKFNVFHWHAVDSQSFPLTSTTFPKITKGSWSSQEIYSTRDIKEIIQHAKEYGIRVELEIDMPGHAYSWGIGYPSVLPANFSHSIQCQQPCPTECNI... | 170 |
A0A251T2Y9 | 3.1.1.11 | ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDKQLFAGVANSSKNKKIFIVFASILLVAAEIRIVDGVNSKTTNTQSNNIRASAAHTIVKSSCSITLHPDLCYSTLSSVPNMTEKVTSLNDVIELAIEKTKERVQKNHLVIKTLEARTNLTTREKFALHDCQEMLDDTLEELDEVIGFLKTYPTEKRNRRHVDDMITYMSTTITNQDTCLDGFSHGKHERQLRESLIDVEINAQKMCSNVLALIKHLTNTDTVDQVKTNTRKLMNKDDEKWPEWLSAGDRRLLQSETVTPDVVVAADGSGDFTTISAAVEAATNRSSRRFVIGIAAGVYSEYVNVDNNKWNLMFVGSGLN... | 125 |
W1PJ38 | 1.11.1.7 | ACT_SITE 27; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLVTDAVRSASTFDQTVPAKLLRLLFHDCMVEGCDGSVLVEGNGTERADPANASLGGFQVVESAKALVEVFCPSTVSCADVLVLAARDAVRLGGGPNVRVLMGRKDGRVSSEANVRANIVDTTFDLDQMTKIFSSKALNLDDLVALSGAHTIGRSHCSAFSDRFAQDSKGKLTPTDPLLDKKYGNDLLSQCPRNADPSITVDNDPETGLVFDNVYYQNLVMGKGLFHSDSVLFGDTRTRNKVLRFAESEESFFEGWERSFLRLTSIGVKTGNQGEIRRLCREING | 14 |
T1G4U7 | 2.7.11.1 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 531; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | QTHTNTHTHITVNLDGKEKVGIKDFEILKVLGEGTYGRVFLVRKITGPDSNKFYAMKVLKKAEIVVKAKNAEHMMTERQVLEHIRRTPFVVTLHYAFQTDEKLHLILDFVNGGDLYSSLNSRGGFNEEQVKVYIAEIAIALESLHKIGVIYRDLKLENVLLGADGHIVLTDFGLSKEFLPADKYHRTYSYCGTVEYMSPELASKCKDGHDYTVDWWSLGVLCFELITGSNPFSNGDLGEDTVNRLITSVEPSVPAFLSRHLASLIRSLLQKNPKFRLGRNGIDDLKAHPFFNNLDWDKLQRKGLPPPFKPKIINDYDVSN... | 99 |
O59923 | 2.3.1.286 | ACT_SITE 348; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MTTFWSQTINRQNGGVATATATATATAATTTPTAGGTGAGTTTSTKGMITPTPFNIDINNDLNDFDGKFIETFKPDLELQKKYRSFIQREGALSFLRTEITQSMSKRDICVLILNLGYPKKAVEDYPILTLKELAYILLKLMLTDSAQLEPKVEIDENDNKNDGTNNSDIDSDIDSNSDMDSQSESGELDDAMDVDDSLSENEDEYDQDMSTTTLKRTINMTPFKYKLPDLISDLSRAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREPGLFYTIAHLVLPPDGKFSLLHAFLKLLQDKH... | 58 |
O14299 | 2.7.11.25 | ACT_SITE 1161; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGLEHTFYPAEDRFEPLLEHSEPVNFVPKENAKSYVRQGFASPHQSLMDNLVDSTESTKRSENFVSHIPLTPSHSGQSEKLMSTRTSHSPYISPTMSYTNHSPANLTRNSSFNHQHYSTTLRSPPSMRGRGIDVNSSHYPHISRPRTSSDSQKMYTRAPVDYYYIQENPYFNNIDQDSISDKSLPSTNQSLHHSEEDTESDNDFSESIHPEFDIDVFYKVSNILYDESDLQDPEKRERLEWHSMLSSVLKGDVMQTEKRRLRLTEPDGHSGTYISEVWLGLQAWLHGRLNADQAEVIRKSREGVEPVLREVIDFQIQDEE... | 105 |
B8BY54 | 3.4.25.1 | ACT_SITE 10; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | LSPNEVSMGTTILAVRYNGGIVVGADTRTSVSGYVSNRYAAKLTFVLDREWTSTCVICRSGSAADTQHLASVIRTELVARQLLYRIRGTVSHAASLSRNLLVNEPNLSASLICAGYDHVLGRGVIYTISPGGTVFEERAWAAGGSGSSYILGHLDSFNPRYERGGSNLLLESEEEALDFVCNAIGLAMDRDGSSGGFARMYVIDRCG | 180 |
P44497 | 2.7.1.23 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MNHLYRSFKTIALVGKPRNDINLQMHKNLFHWLMERGYQVLVEKEVAITLELPFEHLATLEEIGHRAQLAIVIGGDGNMLGRARVLAKYDIPLIGINRGNLGFLTDIDPKNAYSQLEACLERGEFFVEERFLLEAKIERASEIVSTSNAVNEAVIHPAKIAHMIDFHVYINDKFAFSQRSDGLIVSTPTGSTAYSLSAGGPILTPNLNAIALVPMFPHTLTSRPLVVDGDSKISIRFAEHNTSQLEVGCDSQITLPFTPDDVVHIQKSEHKLRLLHLKIIIITMC | 89 |
E3KWQ4 | 3.1.1.11 | ACT_SITE 61; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFNINVVNNYGTGTNTQAVALTAQGERHVYSMCSFSSYQDTLYVKSTSAYFLGCNIEGAVDFIFGGGTAWFEKANIVVKPPRSFATITAHKRVQASSPAKFVFNLSNIVGAPGTRAGSAYLGRPWSALAAVTFQFCSLSNVVNPAGWAAWNPPQDSRTQSVQFYEFQNSGPGSQGRRLFGKASVLPLKIEQVLGPNFASWAT | 125 |
B9RNC0 | 3.1.1.11 | ACT_SITE 194; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"; ACT_SITE 515; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MANLHSFLFALVLLLLPFSSSSTALNCQPNQSKFARTITVDQSGNGDFTSVQSAIDSIPEMNTQWIHIQISPGKYREKVTIPVKKPCIFLEGAGIRLTSIEWGDHEATSTSATFTSYPDNIVAKGITFKNTYNLDITKINWWGEKIIWRQAVSARIKGEQCAFYKCAFLGTQDTLWDEKGRHYFSNCYIEGAIDFIFGKAQSIYEGCVISVNIGKYPPGLQGCITAQKKEWPQHSSGFVFKNCVVSGTGKAFLGRAWGPYSTVIFYNSTLSDVIVSEGWNAWNYVHHEANFTYAEANNRGVGADTSKRVPWEKKLNADQL... | 125 |
Q5LRA7 | 1.8.1.4 | ACT_SITE 443; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAAQSYDVIVIGAGPGGYVAAIRAAQLGLKACVVEREHLGGICLNWGCIPTKALLRSSEVFHLMERAKEFGLKADNIGYDLDAVVKRSRGVAKQLSGGIGHLMKKNKIDVVMGEATIPAKGKVSVKTDKGTQELTAKNIILATGARARELPGLEADGDLVWTYKHALQPVRMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFVKQGMKIMEKSMVKQLDRAKGKVTAHIETGGKVEKLEFDTVISAVGIVGNVENLGLEALGVKIDRTHVVTDAYCRTGVEGLYAIGDIAGAPWLAHK... | 36 |
W5NDV2 | 3.2.1.143 | ACT_SITE 271; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 289; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 290; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MSLRPLCYSHSQTVLIDVNAFKAKKELKPQEGRDHWHGAFVKMPCSEHSMYTKKSMVGKDYIMSDSVRRWESIKKKLSRLSKEPSVTDVEEAIKKYNPAYKDEWSFDALHEFYKNSPKDKRDCSRTLGKIAELAVSLPDVCRMAIPLLRQGHNHSITLSQKQIACLLANAFYCTFPNRNTTKQHSEYSNYPDINFSRLFGQYSERKHQKLQTLFHYFRTVTEACPRGLVTFERRHLTEQISWQHCNDTISKLHVQSDGTIETEGEGMLQVDFACNLVGGGVLGNGLVQEEIRFLINPELIVARLFTEKLGDRDCLRITGA... | 159 |
H2MJI7 | 3.1.3.48 | ACT_SITE 213; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000926-1" | MEAEFLEIDENGSWNAIYQEIRQQSCELPCKIAKLPENKNRNRYRDVSPFDHSRICLQLGANDYINASLITVEEAQRNYILTQGPLPSTCGHFWEMVWEQRSRGVVMLNRVIEKGSIKCAQYWPYKEEKDAIFEDTNFKLTLVSEDVKSYYTIRQLELENLSTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGCLNSDQGPVVVHCSAGIGRSGTFCLVDTCLLLMSLRKDPSSVRIRDVLLEMRRYRMGLIQTADQLRFSYLAVIEGAKYIKGDVSLQESWKELSNEEDDPPEFTPPPPLPPPRDPYNGKTG... | 149 |
Q8EKK0 | 2.4.2.1 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01627" | MSTPHINANPGDFAKTIIMSGDPLRAKLIAETYLEDVKEVTNVRGILGFTGKYKSKDISIMGHGMGAPSASIYFHELMATYGVKNFIRVGSCGAISDNIHLKDLIVAMGASTDSKINRIRFLDHDLAAIANYDLLQACIEVLKTTTVNYKVGNVFSSDLFYRPNENDYTLMAKYGVLGVEMEVNALYALAAEHQCRALALCTVTDHIVQHEHLTADERRTDLHEMVKVALETAIKI | 75 |
Q9VA38 | 2.7.11.1 | ACT_SITE 843; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MHPAGEKRGGRPNDKYTAEALESIKQDLTRFEVQNNHRNNQNYTPLRYTATNGRNDALTPDYHHAKQPMEPPPSASPAPDVVIPPPPAIVGQPGAGSISVSGVGVGVVGVANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGAGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPPPPVPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQS... | 99 |
W1NWF5 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRSGAGTLMALICFLVFAHIVSMGDAHGHGSSLKVGFYRRSCPSAEAVVRRTVAKAIARDPGLAAGLIRLHFHDCFVRGCDASVLLDSTPGNPSEKESPANAPSLRGDEVIDEAKAILESQCPQTVSCADILAFAARDSAHQVGRINYLVPAGRRDGRVSIEREVLQNLPAPFDDLKQLQANFSSKGLSLEDMVTLSGAHSIGRSFCPSFTDRLYNFDSPDGQDPTLDQAYASYLKTKCPAPATPDVTVAMDPLSPNVLDNKYYINLRMNRGLLASDQALMTSPATARMVRQNAHYPGLWAHKFGSAMVRMGFIDVLTGS... | 14 |
A0A3B6RLX4 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAGAPLVLVMLVAAVGVVAAERGGGKLRQGYYEQSCPRAEQIVKDYVERQVPLEPSVAATLIRTHFHDCFVRGCDASVLLNATTGGGEAEKDAAPNLTLRGFDFLDHVKALVEQECPGVVSCADVLALASRDAVGVIGGPFWRVPTGRRDGRVSIKQEALDQLPAPTMNFTDLLASFRAKGLGVADLVWLSGAHTIGISHCNSFSERLYNFTGRSGPGDADPSLDAEYAANLRRTNCTTPTDNTTIVEMDPGSFLTFDLSYYHGLLKYQGLFQSDAALITDDAARADVESVAKGPPEVFFQVFARSMMRMGMIEVKTGSD... | 14 |
T1EMD6 | 2.7.11.1 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 466; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MPLGPLTYPWQRIELAADEPSFLTEPSHFELLRVLGQGSFGKVFLVRKIKGSDTGELFAMKVLRKATLKVRDRLRTKMERDILAYVNHPFIVKLHYAFQTEGKLYLILEFLKGGDLFTRLSKEVMFTEDDVKFYLAELALALDHLHQLGIVYRDLKPENILLDSEGHVKLTDFGLSKEAIFEEGKTFSFCGTVEYMAPEVVNRKGHDSAADWWSYGVLMFEMLTGALPFQGSNRKETMTMILKAKLGMPPFLSPHAQSLLRCLFKRNPANRLGSGPGGVDDLKQHSFFSSINWSMLYDRTIPPPFKPCVHLFDEAFHFDS... | 99 |
A0A9R0IZA4 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNSNKYFSALFVIITLGLISAVSCQDLSCNYYDKDCENFEEIVAKKVWEWFKKDKTIAASLIRLHFHDCAVRGCDASILLDYPGSEKWAKASKTLRGYEVIDDIKATLEKKCPNLVSCADILTAAARDATVLVKGPYWSNEYGRKDGLISVAQEADDLPNGREDVTTLIEFYQALGLNMLDMVVLSGAHTIGRSTCGAIKNRLSRYDENGKLHSTIMAPTYLNYLRRKCKNDTNYVDLDARTPYTFDNEYYKNIEKNMGLLYSDQALYTDHRTSEYIATLANDDGGSFPYLFSSSMVKLGNILGDAQDDGEGEVRQHCSR... | 14 |
Q8A5K5 | 3.5.4.33 | ACT_SITE 57; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MMTLDDTYFMKQALIEAGKAAERGEVPVGAVVVCKERIIARAHNLTETLNDVTAHAEMQAITAAANVLGGKYLNECTLYVTVEPCVMCAGAIAWAQTGKLVFGAEDDKRGYQRYAAQALHPKTVVVKGILADECATLMKDFFASKRR | 186 |
B9SI53 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQTKIPFLFFLFVLPLALGDLRVGFYQSTCPQAESIVFQVVQNRFKTDPSVTAALLRLHFHDCFVRGCDASILIDPTNKKQSEKQAGPNQTVRGYEIIDEIKNALEAACPSMVSCADIIALAAKDAVALAGGPNYSVPTGRRDGLVSNIGDVNLPGPQLTVPEAFQFFRPKGFTVGEMVTLLGAHTVGVAHCSFFQERVSNGAFDPTMDSNLAANLSKICASSNSDPSVFMDQSTGFVFDNEYYKQLLLKRGIMQIDQELSVDGSSAGFVSSFARNGIGFKQSFGNAMVKLGTVEVLVGNAGEVRTNCRVFNAQKKPMNP... | 14 |
P07669 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000250"; ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000250" | MARKFFVGGNFKMNGSLESMKTIIEGLNTTKLNVGDVETVIFPQNMYLITTRQQVKKDIGVGAQNVFDKKNGAYTGENSAQSLIDAGITYTLTGHSERRTIFKESDEFVADKTKFALEQGLTVVACIGETLAEREANETINVVVRQLNAIADKVQNWSKIVIAYEPVWAIGTGKTATPEQAQEVHAEIRKWATNKLGASVAEGLRVIYGGSVNGGNCKEFLKFHDIDGFLVGGASLKPEFHNIVNVHSL | 213 |
Q6C6T4 | 2.2.1.1 | ACT_SITE 419; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MAPQFSKTDETAINTIRTLAIDAVAKANSGHPGAPMGLAPVAHVLWNYYMNFTSSNPEWINRDRFILSNGHACMLHYSLLHLFGYDITIDDLKNFRQLNSKTPGHPEAETPGIEVTTGPLGQGVSNAVGFAIAQAHLGATYNKPGYDIINNYTYCIFGDGCMMEGVASEAMSLAGHLQLGNLITFYDDNHISIDGDTNVAFTEDVSQRLEAYGWEVIWVKDGNNDLAGMAAAIEQAKKSKDKPTCIRLTTIIGYGSLQQGTHGVHGSPLKPDDIKQFKEKVGFNPEETFAVPKETTDLYAKTIDRGANAEKEWNELFAKY... | 51 |
Q86M34 | 3.2.1.52 | ACT_SITE 347; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P07686" | MIVLLLLISYCFAGNGVNVKNQLLLMPYPTTVNAQFGSNDCVEATSNIKMVLSNNCQNDPNCLSFMTFNFNHTITYPLQRQRNLEDFRVSIFAPIDIEEMKGNVVYSANTVNIELTGNNIEEIYPPLKIGIDESYSLDVTKEGIKISATTVYGARLGLETLIQMLRPYQGKYIIKHIPIMIEDKPRLQWRGLMIDVARNSFSRSAFVKIINAMAAIKANVLHIHLSDAQTFMFESKEYPELSKKGAFFQNKVLTQSFIKQLVQYGAKRGVIVYPEIDTPAHTASWNAGYPGVVADIWDYIVSSSMRYGENVLALNPANEK... | 170 |
A0A3B6ESG4 | 1.11.1.7 | ACT_SITE 97; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVCARTASAPLLAAALVAALAVACSLVSGAYAAAEQEAAGAGGNDLRLRQPPITRGLSFDFYKRSCPMAESIVRDFVRDAVRKDVGLAAGLLRLHFHNCFIQGCGRARVMHACRAATGPGEQRAPPNLTLRPSAFKAINDIRDRLERECRGAVVSCSDILTLAARDSVVATGGPEYRVPLGRHDSPRFATPQDVLSGLPATTSAVPSLLDVFHNHSLHLDATDLVALPGGHTVGLGHCVSFEVEFPQAVDPTMSPDFLGRLKRTCPAKGTDARTRDVRTPDVFDNKYYVNLVNREGFFVSDQDLFTNEATRPIVERFARS... | 14 |
Q55FJ6 | 2.7.11.22 | ACT_SITE 125; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEKYQFIKQVGDGAYGDVIKAIDVKTGEIVAIKRMKKKFSDWKECIQLREIKALKKLKHPNIVKLLEIILERDELFFVFEYLENNLYESIKDRTKLLPETTIRNIIYQILQALHFMHTNGFFHRDLKPENIMLVGERLKIADFGLAREIESKPPFTDYISTRWYRAPEVLLRCTYYNAPIDIWAVGAIMAELYSLKPMFPGSSEIDQLFKICTIMGSPTSATWIDGIKLANSMGFTFPNVQPPSINPLSTLLPNANQDAIELITDLLQYDPLKRPTPLQALQHRYFKVSIPSSILLKPNFIELSNKYLIKNGYINNNINN... | 102 |
A9WEF6 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MATPPQVGEMAPDFTLPNEAGEPVSLSQFRGKRVILYFYPKDDTPGCTSQACGFRDSYPVIEEKNAVVIGISPDGTKSHAKFKTKHNLPFILLADEQHSVAEAYGVWGEKSMMGKKYMGIIRSHFVIDEEGRIVQAEIKVSPADSVKRALAALGL | 12 |
D7SIE1 | 5.1.3.3 | ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 319; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKIRELCCFLLLAFAIAKVSEASSEIGVYELKRGNFSVKLTNYGATVVSVILPDRNGKLDDVVLGFDSVEDYKNDTTYFGAIVGRVANRIKGAQFTLNGKKYKLVPNEGKNMLHGGPKGFSDVIWHVQSYDKNSHVTFVYHSFDGEEGFPGDLHVSVTYMFFQTNKLVIKMTGRPLNKATPVNLASHSYWNLGGHSSGDVFSHQVQLFADKITPVDDELIPTGKILPVEGTPYDFLNIHEIKTRFHELPSGYDINYVLNYVGNEHFHKAAVVYESKSGRKMELWTNQPGLQFYTSNMLGTVKGKGGVTYNNYDGICLET... | 211 |
Q54EN4 | 5.3.4.1 | ACT_SITE 70; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 73; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 406; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 409; /note="Nucleophile"; /evidence="ECO:0000250" | MNKFLALLFVLALFANIAFSCEGHPEHDHGDGDHEHDHDESFVKILDSDNFHNSVSEHDVTLVMFYAPWCGHCKTLKPLYEEAAKQLSANKKIAIAKVDCTQHEQLCKQNKVQGYPTLVVFKNGKAEPYEGDRTTKSIVQTLEEELKPTISTLESNEDIEEFKKQHPISVVGFFDNDHDDRFKLFSELAGNNKKSAKFAVVIDKDFSKEHVESTPNVVLFRSFDEPTVAHKGEFDSESLIKFIKGNSVPLLGEINRNTYKKYESIAVPLAYLFIDSTQDNTQVLEDVKKIATSQKGNAVFCWVDMKKFPQQATHMGLSGK... | 215 |
B8BZT5 | 4.2.1.11 | ACT_SITE 209; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 348; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSAITGIHGREIIDSRGNPTVEVDITTAQGTFTASVPSGASTGAYEAVELRDGGSRYLGKGVSQAVNNVNTVLADAVKGIDVADQRAVDDAMLKADGTPNKGNLGANAILGISLAASKAGAAAKGVPLWKHYADIAGNPTPDVLPVPCFNVINGGEHAGNKLAFQEFFVIPTGAETFSESMQIGCEVFHNLKKVIKAKFGGDATLIGDEGGFAPPCDVESGLEMIMEATEAAGYLDKVSVGLDVASSEFKVPGKNQYDLDFKTKGADKDSSLLLSGDELIAFYKQLIDKYPIVTIEDPFDQDDWDNWTKICKEVGKDVQI... | 200 |
Q55EE4 | 1.11.1.24 | ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTKLKVGNIAPDFEAKNYLGQTVTLKEFKEKSQPIVLYFYPKDNSPVCTKESCEFRDKYQKFIEAGAEVIGVSSDGEDSHKSFVSKYSLPFTLLTDKHSKLAKLYGVNGILLPGRKTFIIDKHGIIAGIHDGLLSSTSHIDESLKIIEKLKSQI | 12 |
Q9V3P0 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:Q06830" | MPQLQKPAPAFAGTAVVNGVFKDIKLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSESAAEFRKINCEVIGCSTDSQFTHLAWINTPRKQGGLGSMDIPLLADKSMKVARDYGVLDEETGIPFRGLFIIDDKQNLRQITVNDLPVGRSVEETLRLVQAFQYTDKYGEVCPANWKPGQKTMVADPTKSKEYFETTS | 12 |
A0A2I4FHF2 | 3.1.1.11 | ACT_SITE 224; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVGKRTSCVAVHAALMTVLLIAISVVSDDAAPIPADNAQLNTWFDNNVKPYTQSKGTLDPALVKAEEGVKVIKVRRKGGANFKTITDAINSIPAGNTRRVIIYIGHGVYKEKITIDPSKPFVTLYGAPNSMPTLTYDGTAAQYGTVDSATLIVQSDYFVAANIIIANSSPRPDGRRKGAQASALRISGDKAAFHNCKIKGFQDTICDDRGKHFFKDCYIEGTVDFIFGSGTSLYMNTTLNVLGDGGFTVIAAQAREYDDETGYSFVHCSVIGTGIGTYLGRAWMNKPRVIYAYTIMSGVVSPVGWSDNFHKERDGTVFYG... | 125 |
A0A9L0R4E2 | 3.1.3.48 | ACT_SITE 454; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 456; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MNVSVIVAVPSEQAFFSQGPCRVAEGGGVGVGGWRGGWALASSATGERERARLGCRRSEQRGGSGSGRARAPRPAPRAPRPAAGGVRPPSPAPRLGARTRPRSGAGTGRGQREGPAEGGEGAGPPRAGGGRGSPGGGGSGGGSVPAAVAPPRRTRARTRTRTRTAPGRPLHRARYKEMLELVISPSLSVNSDCAGKLKLGRADADVWTLSDAAGITASAPPAPPSVSQLLARPCARILPSQPPSAMAAYGQTQYSAGIQQAGPYTAYPPPAQAYGLPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPPTGQSPYTYQMHGT... | 149 |
A0A7M7ND46 | 3.2.1.143 | ACT_SITE 546; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 564; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 565; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MVLIEAVIQHHLIMPKRRERELDDSAQKRFRQSTLDFRVKAKDEGKKGAFEADLDEEATMSAEERAEMQRRRDLIAAAAEKRKQSGSPWKTPPDSPENPEDNDSNLMQRSSPSKTSELPTEAGVNSRTKSKRIAALSEASDGALQERTSTPKQDPENSVYRRTDRFDYVEESANKGLSADELERPSTSKDGRKVTRNSGNGEDEDEVKRSEVNYSQMEPASPTLEYMYDGDGSQPLFTDSEPLEEEEVNSKDVPTSYWKGSPISELHRAPACTEVLPEMRPSQDHTILFTTPMKLDVPPAAFPDDYQDKWDGDHVRMPCS... | 159 |
E9GHI8 | 2.3.2.26 | ACT_SITE 681; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MVGNTVSFTVQFFQRWSRRPYPVSDADSIRINIRQGANKIAAAVQIGSSMATEANLVKATFTVRRAGQYHIDINLGSIPIRGSPFVKYFRPGPPDPSKTTLVRPTSMVVCTAGIPHQLLLEPRDEYGNYCSWNHDAPGQQKALDAFSCEAYAIGSSDIVRPLVQWLWVELMHRLIINVTFNEEGIYGVRLKLDDSIINKGEFNMIALSRSEAVQVEKALVTRTATYETKLLTINGEKWNKNKKVFFSISPKQIALKEYILGIIPKRLATFRLCPATKVTFLKNTNKQEFPVLVIEDGAQFTVELSSKEAHLMAASFAHYL... | 65 |
G7KIW9 | 3.1.1.11 | ACT_SITE 193; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFRLFLVPFIFLLVGLVVQETNGQYYKKVGNKIFPFSTIVVDQSGNGHFSTIQSAIDSIPFYNTNWVAIRVKAGIYRASPRRKSCDPTEQILHYIGRGLGKRKTIVEWYDPDGPERSPTFSILADNIHVRCMSFRNSYNNPINGNRKLRAVATTVSGDKVNFFRVAFYGYQDTLYDANGRHYYKLCTIQGAVDFIFGAGQSLFERCSISVIGGGFITAQGRESPNDTNGFVFKDCHIFGNANTYLGRPWRPYARVLFYKTNMTKIVEPSGWDSWSPDGREDLSTYAEYGNFGPGADTSKRVSWAKKLDLSTVENMANLNF... | 125 |
O84192 | 5.6.2.2 | ACT_SITE 122; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDARDGLKPSQRRILYAMKQLNLTPGVKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSAIFLLEDLDKDTVDMVPNYDETKYEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANSQTSIEDILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKLRLRARMHVEENSDKQRENIILTEMPYNVNKSRLIEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVVINRL... | 222 |
D6X1Q0 | 1.11.1.24 | ACT_SITE 85; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MAGLFSTIVRRGPQLLKTAIPAGKNHAFRNFSVAPTLCAPRVQHPAPDFKGTAVINDGFKEIQLSDYKGKYVVLVFYPLDFTFVCPTELIALDERYDDFKNLNAEVIGCSIDSHFSHLGWMNTKRSEGGLGKLRYPLLSDINKTIARDYDVLLEKEGIALRGLFIIDPNGILRQITVNDLPIGRSVDEALRLIEAIQFFEKNGEVCPANWKKGSKTIKPDPQGSKEYFQAANK | 12 |
A0A2R6W0K6 | 5.4.2.2 | ACT_SITE 211; /note="Phosphoserine intermediate"; /evidence="ECO:0000250|UniProtKB:P00949" | MAFSAAASASTNLVPAVASGRGGAAASASQHGETARLARFGVSSSACANALSLSSSRSCASMGEVLWANGGAVRLAARRTLRVRAAGAGTIVQPEGFQITSVPTTPIDGQKTGTSGLRKKVKEFQSPNYLANWIQALFDSLPAEDVKGSTLVLGGDGRYFNKEASQIIIKIAAGNGVGKILVGREGIASTPAVSAIIRARKANGGFVMSASHNPGGPKYDWGIKFNYSSGQPAPESITDKIYGNTLSIKEIKQADIPDVNLSELGVHKFGDFSVEVIDPVADYLNLLEEVFDFDLLKGLLTSKDFRFKFDAMHAVTGAYA... | 216 |
Q6TMK4 | 1.11.1.7 | ACT_SITE 101; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00298" | MRLNLISFFIIFTILVSISNSQEFRSYTGEGNNKQNPKQGSIFTPFIRLANPIKFNKNGFPNITNQPSRAISNIIFDQQTHIGSKEHLTDMFNMWGQFLIHNMALSKPEPNSWPIKVPKCDQYFDPACIGNKTMNYFRTRATEVPCDVGKTVVDEDGKCYEQINSLGSYIDGNVLYGNSEEICKNLRSLSGGEMKMTVTDVGDLPPKNVPGVPMDNDANLFPIDQLYSVGERRGNENPGLLSIHTLLLRDHNRLARKFARLHPEWDDERVFQQSRSCIIEQIQKITYDEYLPTTLGSFPSYTGYDANVNAQVSNEFTTTA... | 14 |
P91931 | 4.1.1.50 | ACT_SITE 10; /evidence="ECO:0000250"; ACT_SITE 13; /evidence="ECO:0000250"; ACT_SITE 66; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000250"; ACT_SITE 80; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000250"; ACT_SITE 237; /note="Proton acceptor; for processing ac... | MLENGSHFFEGVEKLLEIWFEESSNGDDDLRNISRSDWENVLSNVNCQIISTSKNDIIDAFVLSESSMFVSKRRWILKTCGTTTPLKCLGQLLKLAEANGYNVVADLFYSRKNFTRPEAQITPHQGFTEEVTYLDSIFPNGRSYCLGSMNLECWYLYTFSRSDIKITPQLISDEKNVDSDPDQTIEILMQDLDPETMSIFYKNKFNDANGATVKSGIDTILPTMHIDDFLFDPCGYSMNGINDKGEYMTIHITPENQFSYVSFETNVALSNYRKLINQVINTFKPGKFIVTIFANKCSLAYETMKELEVEYSQGSHWKRT... | 196 |
A0A2R6WE21 | 3.1.1.11 | ACT_SITE 168; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTSSQGRWEISVAQDGSGRFRTVQEAIDAVPLSNNRRVVIRIGPGVYSQPIYVPKTKNLITLTGTDPNRTTLSWHNTATSIQHHQAPSVIGTGTFACGSVIVEGEDFIAENLAFENAAPQGSGQAVAIRVTADRCSFYSCRFLGWQDTAYLHYGKQYFRDCYIEGSVDFIFGNATVLLEHCHIHCKSQGFITAQQRKSADESTGYVFLRCVITGNGDSKSYMHLGRPWGPHARVVFAYTHMDSCILPSGWNNWNNTANEKTASYSEYRCSGPGSDLRKRVPWLTRLSDVEASQFLTTLFIDPRRSWIHARDLHSTSPSFP... | 125 |
A7SJ46 | 2.7.7.7 | ACT_SITE 72; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MSKRKAPDQNPNSEFCDFLTELADYEKNVTRQIHKYNAYRKAAAVLAKHSTKIKDGAEARKLPGIGDKIGKKIDEFIKTGKLEKLEKIRKDEGTSITKELTRVSGIGPAAAKKLIEDGVSSLEDLKRVRGRLNHHQQIGLKYVDEFETRIPREEMIKLRDIVLVHVKKQDKNLTATVCGSFRRGATSSGDIDILLSHPDYTSSSQNYDKKSLLHGLVHCLEKADFVTDTLSLGETKFMGVCILPEERDVRRLHRRIDIRLIPHDQYYCGILYFTGSDVFNKQMRHEALEKGFTLNEYSIRPLGSTGVPGEPLPVSSEQDV... | 121 |
B7Q9K5 | 2.3.1.48 | ACT_SITE 333; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | TKDDMSFQSEGNNNATKSYSSSERSRNRENSDSMMEGALEIGEHYMVRRCDETWHPAEIIQVRPCDQDVGKWEYYVHYEGYNRRLDEWVDRDRFNLSSSQKEEMKNPMTQGDCIEQSDRKITRNQKRRHDEINHIQKTYAEMDPTTAALEKEHEAITKVKYVDRIQFGKYEIDAWYFSPFPEEYGKVPKLWMCEYCLKYMKLEKTYRYHMSECTWRQPPGKEIYRRGTVSLWEVDGREHKIYCQNLCLLAKLFLDHKTLYFDVEPFLLYVLCEVDKQGSHLVGYFSKEKDSPDGNNVACILTLPPYQRKGYGKFLIAFSY... | 61 |
Q9FJU9 | 3.2.1.39 | ACT_SITE 119; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 264; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MARDFKLIFSISILLLLLDCCYGGKVGVCYGRSADDLPTPSKVVQLIQQHNIKYVRIYDYNSQVLKAFGNTSIELMIGVPNSDLNAFSQSQSNVDTWLKNSVLPYYPTTKITYITVGAESTDDPHINASSFVVPAMQNVLTALRKVGLSRRIKVSTTLSLGILSRSFPPSAGAFNSSYAYFLRPMLEFLAENKSPFMIDLYPYYAYRDSPNNVSLDYVLFESSSEVIDPNTGLLYKNMFDAQVDALYYALTALNFRTIKIMVTETGWPTKGSPKEKAAASSDNAETYNSNIIRHVVTNQGTPAKPGEAMNVYIFSLFNEN... | 167 |
A0A3B6MYC3 | 1.3.5.1 | ACT_SITE 316; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MWRSRVSRGLREAKAAAAAASRRFSTTSSYTVVDHTYDAVVVGAGGAGLRAAIGLSEHGFNTACITKLFPTRSHTVAAQGGINAALGNMSEDDWRWHMYDTVKGSDWLGDQDAIQYMCREAPKAVIELENYGLPFSRTEDGKIYQRAFGGQSLDFGKGGQAYRCACAADRTGHAMLHTLYGQAMKHNTQFFVEYFALDLIMDKEGTCQGVIALNMEDGTLHRFRSTNTILATGGYGRAYFSATSAHTCTGDGNAMVARAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGILRNSEGERFMERYAPTAKDLASRDVVS... | 28 |
Q7S604 | 6.3.4.4 | ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 40; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MATLILGSQWGDEGKGKLTDILCPKAQICARAAGGHNAGHSIVANGVEYDFHLLPSGLVNPNCMNLIGSSVVFHVPSFFSELSKLEEKGLTDVHNRILVSDRCHVNFDLHAAVDGLEEVELGDRKIGTTGRGIGPSYSTKMARSGVRIHEIFNEEIFERKLRQLAAGYKKRFGDLLKYDVEEEIARFKEYRVKLARYTVDAIQYMKEAQDRGYKILIEGANALMLDIDYGTYPYVTSSNTGLGGIITGLAINPTKIDNIIGVVKAYTTRVGGGPFKTEDLEEAGTKLQEIGREWGVSTGRKRRCGWLDLVVLKYSTAINN... | 253 |
F0ZLU7 | 2.7.7.7 | ACT_SITE 104; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MAGKRKDKDNSSSDDSSSEDDIKKKKLKTNTPLIKVSVTSNDNKNKQLTDILTELSVFEKNKGQVHRFTAYRKAVLSIKAYPHEIKSGLEAQKLDGVGAKIAKKIDEILKTGDLKKLKSQNQDETLTAINQLSRVTGIGPQKAKSLVEEGIKTIDDLKKIKNTLTHHQQIGLKYFSEFEQRVPRKEIEVFEKLVSNSLFSIDPNIISQVCGSYRRGLESSGDIDILISHPNFTLEMKDKKKTFNIIEKLVESLKKKHILIDDLSLGPLKYMGVCKLVSTEISEQHIARRIDFKLIPYESYYFGLLHNTGSDEFNRQMRGI... | 121 |
B9I6Y8 | 3.1.1.11 | ACT_SITE 198; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQKPLFNAIVIILFITISSSNSQAIDCKPGRGKRVRKTIVVDHSGKGHFIKIQDAIDSIPINNDQWIKVRINPGTYIEQVTIPEDKPCIFLEGRDRTLTTITYNAHESTDTSATFTSSPSNIVAKGITFKNSYNLPFKQNINYGIKIPGVGVAPALSARIYGDKSAFYDCAFLGVQDTLWDVEGRHHFFNCYIEGAVDFIFGAGQSFYEGCSINVTSKGVITAQGREFPNDPSGFIFSGCTISGIEGVRAFLGRAYRPFSRVIFQDSYFSKVVDPLGWNAWGYAGQEENFTYVEVDCKGPGSNKSKRVPWVRKPSTGQHE... | 125 |
A0A3B3IG08 | 2.7.10.1 | ACT_SITE 680; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MSACRALPWTEAAILLLLSGSLCAAQPSLTRQGRTSEPLVIPRHASTVDLSKEEFEQLHFKHDTRFIKLSEGNEAKFNCSIDIPSTMFELNIMWSKNGEELPENIHKVSELRTVADGVSTIFSLVSTNSVHRADAGEYRCSLSINNKTIESQPIFLQVEGLPMFTKHPEDVNVTRNTPFNLSCVAEGPPEPVQIRWLRDGMSYSDFQDSPSNLYVPGVDKYTQFSCEAHNARGLTTSSEGKVNIKVLPSPVLDVNVIERQSNKLNLTWSPGHDGFSPITQCQIRVKEVSLRKGEVMITRSITEKVPPFHCEVTGLKAMTW... | 97 |
Q7UHW4 | 2.2.1.1 | ACT_SITE 433; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MPMTATTTDNQTLAIDTIRCLSMDAVQTANSGHPGTPMALAPIAYQLFQNTMNYDPAKPHWPGRDRFVLSCGHASMLLYSTLHLIGVQATDRYGKPTGGESISLEDIKNFRQIGSVCAGHPEFAEAAGIETTTGPLGAGVSNSVGMAMAEKWLAANYNTDDLTLFNYNTYAICSDGDLMEGIATEAASVAGHLKLDNLCWLYDDNNITIEGDTELAFSEDMGKKFEGLGWNVLHVDDANDVEALGKAIAKFQACGDKPTLIVVKSIIGYGAPNKQNTHGAHGAPLGWDEVALAKKSYGLPEDEKFYVPEGVRKHFAEGVG... | 51 |
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