Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A072U9H3 | 1.11.1.7 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARFCCLDTYSYALFFISSLVLAFHFHASEAQAHPQVVKGLSFSFFSKTCPNLETVVRDHLSKVLKKDNGQAPGLLRIFFHDCFVTGCDGSILLDAKGGKDEKGEIKNVGIRKEALRTIDDIRSIVHNKCGRIVSCADITVLAAREAVFQSGGPLIKVPLGRRDSLTFNTKATSKIPSPFKKTNETIKTFAEQNFDVTDVVALSGAHTFGRAHCSTFSKRLSSKDPTMEKSLAKSLKTRCPNASSDNTANLDLRTPTFFDNKYYLELMNSRGLFTSDQDLFNDKRTKGLVTSFANNQKLFFEKFSVAITKMSQLSVLTGN... | 14 |
P55982 | 1.17.4.1 | ACT_SITE 424; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 426; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 428; /note="Proton acceptor"; /evidence="ECO:0000250" | MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR... | 21 |
A0A804L6B1 | 3.4.21.89 | ACT_SITE 184; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 234; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MSSLQFFSPTSQSPKIKPNHLLSSSSSSKNSVTRATNFSTSFSCSTSQLPTENPNPNPSRCICSSKNPTFSSARCISPPKSSNFWVSRPRQRRSQVGCGRGVEARDGEVDSPPLSEWKSGGGGNGDGGGGNGGEEGDEKEKKKGLLPEWVSITKEDAKTILGALAISLAFRTFIAEPRFIPSLSMYPTFDIGDRVVAEKVSYYFRKPCVNDIVIFKSPPVLQEVGYTDDDVFIKRVVAKEGDVVEVHNGKLVVNGIVKDEDFILESPSYEMSPIQVPENTVFVMGDNRNNSYDSHIWGPLPAKNILGRSVFRYWPPTRIG... | 178 |
Q0DSV9 | 5.6.2.2 | ACT_SITE 185; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01385" | MSEKKRRGGAGAGAASGSASKKPRVSTAASYAESLRSKLRPDASILATLRSLASACSKSKPAGSSSSSSSASKALAAEDDPAASYIVVADQDSASVTSRINRLVLAAARSILSGRGFSFAVPSRAASNQVYLPDLDRIVLVRRESARPFANVATARKATITARVLSLVHAVLRRGIHVTKRDLFYTDVKLFGDQAQSDAVLDDVSCMLGCTRSSLHVVASEKGVVVGRLTFADDGDRIDCTRMGVGGKAIPPNIDRVSGIESDALFILLVEKDAAFMRLAEDRFYNRFPCIILTAKGQPDVATRLFLRRLKVELKLPVLA... | 222 |
A2DWM0 | 2.3.2.26 | ACT_SITE 1060; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDGMQFSPEIVDMALNQLSSPDIDAQLESLSLLGLSLISVSPDEIGSYGIERVVNPVIELFKTSESDFIAEQAALCIRNLLSNSTDAIFPIARAGFIQAAKEKLDNGFSIELAENVIHCFNSIANYTASTLSKIIGIDIFFKFLDFMTIAEQRTSLQTVAVMTEYYQRSDYVNFLPNLCSLTCQQDNRIAKYCINAIGNIIKEMDLDDFPIADIESLSTAITTTTSSDLVYDILIILIRLTDSKKCTEAIAKTNIPYDRLLFSKDFPDSRLDIIQRTLFLFSQLLPRPNYPENILLDEHDAPESALEFSRKARELLIRHI... | 65 |
Q6AVZ7 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVMVKLNAAVAAAAVVLSLLVVVAVHPAAADAGGDWYGKKSIEETVRKEVEKAIKHNPGVGAALVRLVFHDCWVNGCDGSVLLDKTPYSSSTEKAAANNIGLDGFDVIDAIKSKLGAAVSCADIVVLAGRDASAILSGGRITYDVGTGRKDGVVSSAAAADAVLPESTFDFAQLKDNFASKGLTQGELVILSGAHSIGVAHLSSFHDRLAAATATPIDATYASALAADVERQKGVQRTDNPAEKNNIRDMGAAFQSAAGYDAAGVDTAAVGALDNSYYHNNLQNRVLFKSDWVLRTDGDAAADLAEYRDNATKWDVDFAA... | 14 |
G1KE82 | 2.7.10.1 | ACT_SITE 619; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MRTILCGLLKFLAVVATTCAWPAAAPMGGTTEPEMFDSHMMEVEEEHLLLDPGSLLKLYCSTNHSQVISWYKEAKQLSPSGRIHMRQSMLEIAEVTYEDSGLYSCRARSTGETLRNFTISIVDSLASGDDDEDSDVDSSHIDSNEEPVNTRRAPYWTHPHRMDKKLYAVPAGNTVKFRCPASGSPNPIIRWLKNGRDFRGEHRIGGIRLRHQHWSLVMESVVPSDRGNYTCLVENKFGSIRFSYFLDVLERSPHRPILQAGLPANTTAVVGSDVEFFCKVYSDAQPHIQWLKHIEVNGSSYGPDGVPYVQVLKTADINSS... | 97 |
Q9M8J5 | 2.7.12.2 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MVMVRDNQFLNLKLSPIQAPTTIPPCRFPIIPATKVSATVSSCASNTFSVANLDRISVLGSGNGGTVFKVKDKTTSEIYALKKVKENWDSTSLREIEILRMVNSPYVAKCHDIFQNPSGEVSILMDYMDLGSLESLRGVTEKQLALMSRQVLEGKNYLHEHKIVHRDIKPANLLRSSKEEVKIADFGVSKIVVRSLNKCNSFVGTFAYMSPERLDSEADGVTEEDKSNVYAGDIWSFGLTMLEILVGYYPMLPDQAAIVCAVCFGEPPKAPEECSDDLKSFMDCCLRKKASERWTASQLLNHPFLLHQD | 108 |
A0A1U7ZGA4 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEPKRISPVSLDLYNLFILVTLALLFQIGVLAASSESRLFFNFYAASCPTAELMVRNTVRSASALDPTVPGKLLRLLFHDCMVEGCDASVLLEGNQTERSDPANASLGGFSVVDSAKDLLELFCPGTISCSDILALAARDAVEFAGGPSVNIPTGRRDGRVSSVSNVRPNMVDTSFTLDEMLELFSSKGLSLDDLVTLSGAHTIGSAHCSTFSDRFQEDSNGTMTSIDASLDKIYARELIKQCPIGASESVTVNNDPETSLLFDNQYYRNLISHKGLFQSDSVLFVDGRTKAKVEELSRSQEIFFQQWTQSFQKLCSVGV... | 14 |
P43063 | 2.7.11.22 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVELSDYQRQEKVGEGTYGVVYKALDTKHNNRVVALKKIRLESEDEGVPSTAIREISLLKEMKDDNIVRLYDIIHSDSHKLYLVFEFLDLDLKKYMESIPQGVGLGANMIKRFMNQLIRGIKHCHSHRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRAYTHEVVTLWYRAPEILLGGKQYSTGVDMWSVGCIFAEMCNRKPLFPGDSEIDEIFRIFRILGTPNEEIWPDVNYLPDFKSSFPQWKKKPLSEAVPSLDANGIDLLDQMLVYDPSRRISAKRALIHPYFNDNDDRDHNNYNEDNIGIDKHQNMQ | 102 |
Q1PFB9 | 2.7.11.1 | ACT_SITE 271; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MLTKPGKKLDSSESTHHTTSSNYPPLDIVHQTPQPRKEMQQKPLFDPKKMDNLIKPEPAGFTNHHRPNPSPKIPSSPGSNMTESQSNLNTKPNNNNSNNNSNMSSRSNSIESTSSNPSKPHTGGDIRWDAVNTLTSKGVQLGISDFRLLKRLGYGDIGSVYLVELRGTITYFAMKVMDKASLASRNKLLRAQTEREILSQLDHPFLPTLYSHFETDKFYCLVMEFCGGGNLYSLRQKQPNKCFTEDAARFFASEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCSVSPTLVKSSSVHAAGGGSGSSRP... | 99 |
A0A022QQ08 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMRVGVIVGVVFVVVVVLGCLKNGEAVGVGLSDNFYEESCPEVESIVRAGVQSASLTDPTTPAALLRLMFHDCQVQGCDASILVNPDGVITKSSEMGSTKNFGIRKRELISLVKSAVEAVCPRRVSCADILVMAAHEAVAFSGGPRIIRLPLGRRDSINPPNAGLADASLPHADIGLDSTLQLFAKKGMTIEESVAILGAHTLGVTHCINLQSRLYSTQKSNATNQNPAFELSLKTRCPQLAGPTASKISFMQNDLTSVIFDNEYFVNLMRGRGLLNIDSDMAVDSRTRQFVEKFAEDQGAFFRAFSSAFVKLSSYGVLT... | 14 |
A0A022PWL7 | 3.2.1.52 | ACT_SITE 361; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MNSAITNSLSNLCKKMNIPFMSNPQSYLLLVLLIFSQSQIIRCRNLVLNQQQQQFNNGAGDGDDSLTYIWPLPRQHTSGNQTLTVNPNLSLVTSGNGSNSLIVSEAFDRYKKIIFKHTSSKLPGTGIDYDLNKLSVVVHSDNEELQLGVDESYTLMVAATDKLSIIGEITIEADSVYGALRGLETLSQLCAFDYGTKSVKLYNAPWYIQDKPRFKYRGLMLDTSRHYLPMEIIKQVIESMSYAKLNVLHWHIIDEESFPLEVPTYPNLWKGAYTKWERYTVDDASEIVNFAKMRGINVMAEVDVPGHAESWGTGYPDLWP... | 170 |
G7JQX4 | 5.1.3.3 | ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKVSLLFCVLLGLLVHTHAHSHKSEKSEKIGFYELKKGSMRVNLTNYGASIVAVYVPDKHGKVADVVLGYDSIEQYETDGVYFGGLIGRVANRIGGAQFTLDGKTYKLPANDHGNTLHGGQKGFGDNVWKVKIHKDDSHVTFTYESFDGEQGFPGKLDVSVTYMLLEKNILGVKMTAKPVNKPTPVNLAQHAYWNLGGHNSGDILNHSVQIFGSSITPVDDKLIPTGKLESVKNTPYDFLKPKQVGSQINDLPGLYDINYAIDERKMELWSNQVGLQYYTSGMLTDTKGKDGATYHKYGGIALETQGFPDSVNKPNFPS... | 211 |
F6U370 | 2.7.10.1 | ACT_SITE 774; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MGDTFGPRGVLGVLVLAGFLRTGAPQSTSSWSLPQLVVEAGDSLNLSCDLNSPVWWSFQNWPPEKKVLGDKLYKKQATAHDTGRYTCTDRDLNTSSIYVFVKDPDILFLVDSLLYGKEDSDILVKCSVTNPDLSNLTLRGCDGNPLPPDLKFVSNIEEGIIIKSVQRSYNKVCFQCAAYEGTHLRLSEKMTLKVRSVRKAPPVVILPRTHQLLREGEKFEVTCTIRDVDSSVVSEWITTNNRTSRHAPRSRNFGDYEYEQKSTLSIESVCVGDSGVFTCLANNSFGPASASMTLQVIDKGFIHFLTGTNSTLSVNAGENV... | 97 |
B9RQN7 | 1.11.1.7 | ACT_SITE 116; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVNSIFEIANMKKMTVLVFIICILISFRNQTKEIMIHNEEIKESFEEYYYTSSSWDLLPSFFLSNEQEAHPQTRSLEYDFYRNSCPQAEKIIQNVVRELYKVKFSVSPALLRLVFHDCFIAGCDASILLDAVDGKQSEKDSNPNENLKGYDIIDKIKSQIEEVCPGIVSCADIVVLAAREGVLQAGGPFYPLFTGRRDSTEPFSNLATNELPSPNADLSETLASFSSRGFDERETVSILGAHSIGMIHCKFFLNRLYDFGGTYGPDPSLDPQFLNFLRSKCNTSGASEVPAASPPFDILVSSSTETSPPHSVMSSAAPPS... | 14 |
A0A1B6QLT8 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQPACARSAALLAALVVVLAYSAVSCRGQLANNYYAGKCGNSSVEDIIHDAVKARLAWDKRMVAGLLHLQFHDCFVAGCDASILLDGPNTEKTAPENSGIFGYDFIDDVKTALERVCPGVVSCADIIIAATRDAVGMCGGPSYQVQLGRRDGMVSQASMASILPGPNVDVPTAIDLFGRKGINALEMVSLMGAHTVGVTHCSVIHNRLFDYKGTGLPDPAMDPMYVWILTTYACPKGQAFDNIVYLDDPSSILLVDKSYYSQIMKRHGVLSVDQALGDHNATAWMVNFLATTDFFPSMFSHALNKLAALDVLTGTAGEIR... | 14 |
Q5JHP5 | 4.6.1.16 | ACT_SITE 107; /evidence="ECO:0000255|HAMAP-Rule:MF_01833"; ACT_SITE 114; /evidence="ECO:0000255|HAMAP-Rule:MF_01833"; ACT_SITE 145; /evidence="ECO:0000255|HAMAP-Rule:MF_01833" | MIIFYLSGDRVFSTDQNAINGLYNKRYFGKVVEGKLFLSLLEAAYLVERGKIEVRDGKRKLSLEEIMNLGRARDELFDAKYLVYKDLRDRGYTVKSGLKFGSHFRVYRRGMEEHSEWLVWVVPENSRLSPNDITARVRVAHGVRKNMIMAIVDEDADVTYYKVEWVKF | 207 |
F6GZ26 | 3.2.1.52 | ACT_SITE 333; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MAVSDKALFSIVFLFTAFVSSISASESQSQINVWPKPRTFSWPSPQASLLSPNFSITSPNHQHLSSAVARYLRLILTEHHHPLVTPTVNITGPPLETLTIIVSDLAAPLHHGVDESYTLIVPRGGAANLTAATVWGAMRGLETFSQIVWGDPLRVATGLFVWDSPLFGHRGVMLDTSRNYYGVEDILRTIGAMSANKLNVFHWHITDSHSFPLLLPSEPDLAGKGSYGPQMQYSPEDVKKIVEFGLEHGVRVLPEIDSPGHTGSWAEAYPEIVTCANMFWWPAEAEWADRLASEPGTGHLNPLNPKTYQVFKNVIHDVAA... | 170 |
A0A3B3HC84 | 2.7.10.1 | ACT_SITE 792; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MEYHWILLFVFLQFTFPSGNTKPTIIPAKPQLVVELNQEFELQCWSDNKTHWRREERTKPLRASQINGKLTLAFQKADPASMGRYICVDEGTKEQASIYVFVKDPKNPFRKPLVPKILTREGDPASIPCLATDPNLSNLSLETCSRGPLAFGLQFTANLEQGILIHNTRKAYGGCYRCTGTLQRQTVESNEYELTVRPVPDEPPVVEMHQPTQVILTRNQTLSLTCNTTNVNGDITLRWIVPPGSGAVWYPQQPAKVDGTARIQLEKFTHTRSSTLHIAAVRPEDTGSYKCEARNEKGISTKSVWLDVYERGFISLTPSA... | 97 |
Q5B7U2 | 3.2.1.1 | ACT_SITE 211; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001024-1"; ACT_SITE 235; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001024-1" | MKLASTLAGLLLPLISTVSAADVDAWKSRNIYFALTDRVARGSDDTGGDACDDLSTYCGGTFKGLEGKLDYIKGMGFDAIWITPVVANHDGGYHGYWAKDLYSINENYGTADDLKSLVSAAHEKGIYIMADVVANHMGSPISDNQPESLSQESAYHSACTIDYSSQESIETCRIADDLPDVNTESEEIRTLFKEWITWLVKEYEFDGLRIDTVKHVEKDFWSDFSSAAGVYTIGEVFDGDPDYLAGYANTMDGLLNYAVYYPVNNFYQQAGSAQDIVDMHDKIDSSFPDPSALGTFIDNHDNARWLSNKDDKSLLKNALA... | 157 |
Q67IX6 | 5.3.4.1 | ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 105; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 444; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 447; /note="Nucleophile"; /evidence="ECO:0000250" | MRSRSLLLVALATLLLHASASASDDDLDYLIDNADDIPANDPDGWLQEGSPDDDDDDDLFHHGQAQDHPIDETHVFLLSAANFSDFLASHRHVMVEFYAPWCAHCQALAPDYAAAAADLSPLAHQVALAKVDATEDTDLAQKYDVQGFPTILFFIDGVPKDYNGARTKEAIVSWVNKKLAPGVQNITTVDEAEKILTGEDKAILAVLDSLSGAHSDEIAAASRLEDAINFYQTSNPDVAKLFHLDPAAKRPSLVLLKKQEEEKLTFYDGPFKASAIADFVSANKLPLVNTLTQETAPSIFDNPIKKQILLFVVANESSKF... | 215 |
E9HWI6 | 1.11.1.24 | ACT_SITE 83; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MNSALRTLGFALSRRAALPANASLPQRFLHTGSRLLAAQVQLPAPDFKATAVVDSAFKEISLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSDRIRDFKALNAEVVGVSTDSHFSHLAWINTSRKEGGLGGLNYPLLADFHKTISRDYGVLIEKAGIALRGLFIIDPTGVVRQVTINDLPVGRSVDETLRLIKAFQFVEKHGEVCPANWTPESPTIKPDPVGSKDYFNKVN | 12 |
A0A0G2JUN9 | 2.7.11.25 | ACT_SITE 261; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MESSRSLLGCLASAAAAPPGEDATGAGAEEEEDEEEAAAELGSHATLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGTEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWVGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRVPPDILVNWAVQIARGMNYLHDEAIVPVIHRDLKSSNILILQKVENGDLSNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFS... | 105 |
A0A9R1WVF5 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAIQKHIALLLQFLLVALVFDVANGYPLKLGFYQKTCPRAEAIVKRTTANYIYRAPSLAAALLRMQFHDCFVRGCDGSVLINSTRKNQAEKDGIPNLSLRGFQVIDAAKTAVEAACPGVVSCADILSLVARDAIHQIKGPYWPVPLGRRDGRVSIASESFTLPAPFANITQLKAQFVSKGLSVKDLAVLSGGHTVGISHCSTIATRLYNFTGKGDTDPSLDPRYVPQLKRICFPTDKTTLLAMDPGSSKSFDEDYYSVVLKRRGLFQSDAALLNDKTTSAYVKLQAKSHGYTFFKDFQASMVKMGQIGVLTGKVGEIRKH... | 14 |
A0A251SXV4 | 3.1.1.11 | ACT_SITE 336; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MMALPPWTTKQLLLLVVLIILAAACPGSTFASDDDQFVESVRSTIESVRQVISIVSRFSDVLGGGDFRASNAIADCLDLLDFSADQLTWTLSRAISSSTAKYSSSSSMGADMRTWLGGALGNQDTCMEGFEGTNTIVKSLVAGSLDQVTSLVRQLLSQLPGTIDAAAAGIWLKEKEQKLLVEANIRADVVVAADGSGNFTRVMDAVSAAPDNSARYVIYVKKGVYQEYVEISKKKTNIIMIGDGMNLTVISGNRSFVDGWTTYRSATFAVKGKGFMARDMRFENTAGPEKHQAVAFRSDSDLSVVYRCAITGYQDTLYAH... | 125 |
A7UWT5 | 1.3.5.1 | ACT_SITE 340; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MSSLAWRKLAAAPTLARAASRVQNRAFSSTRPAARVIAPGPLRAKEASPHLSSKYHVIDHEYDAIVVGAGGAGLRAAFGLAEAGFNTACISKLFPTRSHTVAAQGGINAALGNMHEDDWRWHMYDTVKGSDWLGDQDAIHYMTREAPASIVELENYGCPFSRTEDGKIYQRAFGGQSKEFGKGGQAYRCCAAADRTGHALLHTLYGQSLRHNTNYFIEYFAVDLIMQDGECRGVLAYNQEDGTLHRFLANNTVLATGGYGRAYFSCTSAHTCTGDGSAMVARAGLPNQDLEFVQFHPTGIYGAGCLITEGARGEGGYLLN... | 28 |
P59362 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000250"; ACT_SITE 603; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000250" | MCGIVGILGREPVAEQLVDSLKRLEYRGYDSAGVATLEGRHLERRRAEGKLKNLEKRLEAEPLKGTTGIGHTRWATHGKPTVNNAHPHATERVAVVHNGIIENFRELREELEKNGTVFHTETDTEIVLHLVDDLLTRGNKPVEAVKLALARLRGAFALGFIFAGDNDLMIGARNGPPLAIGYGDGEMYLGSDAIALGPFTDTISYLEDGDWVVLTRNSATIFDKDGHAVQREKIKHAASTSLVDKANYRHFMAKEIHEQPEVVGHTLARYVDMATERVSLPVKLPFDFKNIQRINITACGTASYAGFVAKYWFERFARLP... | 81 |
G7ITE3 | 3.4.19.9 | ACT_SITE 111; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 219; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 219; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MLNYAILFLFYIAIFHCFLFTISCPPPNPNLYYQPVIGILSHPGDGTSGRHSNATGASFIHASYVKFVEAAGARVVPLIYNEPEEKILKVSEKATLPKNDAGDHFPLYAICLGFELISVIISEDKNILEEFKAKNQASTLQFVENASIEGTVFERFPPELLKKLSTDCLVMQNHVVTRHIPNKVSSFFEILTTCNDEEDKVYVSTVRSRNYPVTGFQWHPEVIKKVLYTIEARKSLNRPVAQELYDNLIYNIVQLFMQKKG | 176 |
A0A059BHJ4 | 3.2.1.52 | ACT_SITE 219; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MYCSVVFWSYFQGVISVFGGSSSDSFLDMRGIFIKHSFTSFQTFSQLCTFDYSTKLVLVHKAPWYIRDEPRFAYRGLLLDTSRHYYPIDVIKHILDSMSYAKLNVLHWHIIDEESFPLEVPTYPKLWQGAYTRWERYTVEDAYEIVNFAKSRGIHVMPEVDVPGHAESWGKGYPELWPSTSCREPLDVSKSTTFDLVSGLLSDMRKIFPFELFHLGGDEVNTDCWTSTPHVKQWLQNHNMTSKDAYKYFVLKAQEIAISKNWTPVNWEETFNAFPESLNPRTIVHNWLGAGVCPKAVAKGFKCIFSNQGFWYLDHLDVPW... | 170 |
A2DQ30 | 2.3.2.26 | ACT_SITE 650; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSDEGDANIDKYYQLYLAQLTSGCDSLTCTSRHCRSSPNFEHRDKQLQIIALELAEDDSEHLCKHLSPLLTNPKNIEFLAKDAISFQKLIRQQHLSDEDLNNIQLSFTHVDIFCHILLGDDGIITPNNLLFDDSMIDDFYKGIKRNPKILSEYKDFPQLIDMILAKPPSLTKIRGIILLLLLYGVHTCKNYINIYHTVAAFQQIEIYVLFAALSNHPLLLSHILETTHAFIRKYLIDNPDEHPHSTSMHVIAAVMQMFYTANLNFDVPLPSNVFYNEKFCDKLDPRCEAELINITSFSYIIMPAILSLTFKTRTIEQERV... | 65 |
A0A8J0TCF6 | 4.6.1.16 | ACT_SITE 254; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 262; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 293; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MSSVINENMILIQLLEGKAFVWKADDVQMIREQHGLVGNLVGALVRKPRQNSRLGLPLQLLPEEARLLVEVGAAVLVRSLSREKELQKQEVLEPESAESSSSTNEGKDEQPEAAAYEKYLGESYKEQRKLALEEKRRTLESLADRIAEGRSRRKRQRSDQEGDATESPLQGPIKELQNLEETFHFPKEAMMVHLPTARTSCEDVEEVDPRQVSVHWPYAGQKEHEVRFKVFKSLWQKGYFLTNGSKFGGDFLVYPGDPMRFHAHFIAICYPYKEEIALSDIVTAARLGTNVKKTVLLCSADQEGEVTFTSLQWSGLQ | 207 |
O54438 | 1.1.1.100 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10001" | MSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS | 2 |
P0A9C3 | 5.1.3.3 | ACT_SITE 175; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10126"; ACT_SITE 309; /note="Proton acceptor"; /evidence="ECO:0000250" | MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRKVKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP... | 211 |
A0A9R0ID30 | 3.4.19.9 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 283; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 283; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MFPSNTPSSTSHLHSNLWFFLWIPLITSSLSQQLTSAEPNNNIIMLPTSSDYLPAPKSCPVPDPDLNFRPVIGIVSHPGDGASGRLKNGTNVSYIAASYVKFVESAGARVIPLVYTDPIDVIFKKLELVNGVLFTGGWAKNGTYFEVVQQIFKKVLEKNDAGKFFPCYAICLGFELLTMIVSKDNNILENFSASYQASTLQFVDNNVSGTVFQRFPPELLRKLSTDCLVMQNHKFAISPKTLQANHLLSSFFDVITTSTDSDNKVYVSTVQAHQYPITGFQWHPEKNAFEWGYPMIPHSEDAIQVTQHVANFFISEARRS... | 176 |
Q5ANK9 | 2.3.2.26 | ACT_SITE 862; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSQQYPSKNSKVTPNSKHNWNFKDLLTMPTINSAKSKKTVITPNATEHDPTGVQTNESKSTSGTSDNTQSQNVSKCYCCGTILTFPNKAKKFRCSVCHTTMLLGTSPSTDSPDIPLVSYKHVKSLADECFKNANDNKGKLKSLHEIFEPLSNYLYQAFRSFEILNNSFKLRPHSKRPHHSTSNIYYSGVRDVINLLTKLPTKKPLHSALKGASEQLKRIDVYLEDSGPLAYSWVLILFEIPILSRSLVLNNPKLKLMSDVPEIKMLSYDILKRCLGILSCIDNAKTLGYFTSWLSKLDSADFIRRVDLINLYITFQLKKY... | 65 |
D8RHZ4 | 3.4.19.12 | ACT_SITE 81; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 156; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSWCTIESDPGVFTELIQQMQVKGVQVEELYSLDLEALSLLRPVYGLIFLFKWRPGEKDTRPTVKDNKSIFFASQVINNACATQAILSILMNRVEIDIGPELSMMREFAKDFPPELKGLTINNSEAIRTAHNSFARPEPFVPDEQKFADKDDDVYHFISYLPVDGVLYELDGLKEGPISLGECGSGDADSMEWLKMVQPVIQERIEKYSKSEIRFNLMAVIKNRKDLYNQQLAELDRRKNEISGDDGMDVDSKSGSGNEELAQIDAEIARLTEKITQEDEKFKKWKTENIRRKHNYIPFLFNFLKILAEKKQLKPLIEKA... | 175 |
A0A9J7HJ52 | 2.7.1.11 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MASAVLGDLSSSNAFAASNLRQAQGKSIGVFTSGGDSQGMNAAVRAVVRMGIHVGFRVYYIHEGYQGMVDGADNIKEAIWTSVSGIIQQGGTVIGSARCQDFRERAGRLKAARNLVKLGISNLVVIGGDGSLTGANCFRQEWSGLLEELVKKGEITAEQSKNCSHLNIVGMVGSIDNDFCGTDMTIGCDTALHRIMESVDAITTTAQSHQRTFVMEVMGRHCGYLALVTALACGADWLFIPEWPPESDWEDHMCRRLSELRTAGSRLGIVIMAEGAIDQKGNAITSNRVKEIISTRLGHDTRVTVLGHVQRGGNPSAFDR... | 84 |
A0A9J7L7D9 | 2.1.1.33 | ACT_SITE 151; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MASLPQKKFYRQRAHSNPMADHSFDYPVKPDVMDWSPYYPAFFESPSQAERHDDDKEAEERLPSRVEFADIGCGYGGLLVALSPMFPDTLMLGMEIRVKVSDYVTDRIKALRDKHPGEYQNVSCIRTNAMKYLPNFFRKGQLKKMFFLFPDPHFKKTKHKWRIISSTLLAEYAYVLAVGAIVYTITDVEEVHEWMKQHFVQHPLFQQMTAEEYKDDPIVEKLYESTEEGQKVTRNKGDKFLAIFRRIKDPLLPN | 45 |
H7BWW2 | 3.2.1.52 | ACT_SITE 335; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MEQRGLARLRLPGLLALLAALAARTPRVSASGDLNLWPLPVSLKTTPRLFYLSPGNFFFGHSPTSKAGPSCAVLQEAFRRYYDYIFGFYKWHHGHNKIPSEMELQKLEVSVIMDPECDSFPSITSDESYTLLVKGPVATLTANRVWGVLRGLETFSQLIYQDSYGTFTANESNIVDSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSISFPELSNKGSYSLSHVYTPNDVRTVIEYARLRGIRVLPEFDSPGHTESWGKGQKDLLTPCYHAREPSGTFGPINPILNSTYSFLSKLFKEI... | 170 |
A0A1D5UJX6 | 1.11.1.7 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGKATMNIKRQHSTNVTTAALASVLMLLLAAAGSVAAQGRGGGGGYGGGGGYGGGGYGGGGGGYGGGGGGGYGGGGGYGYDGGYGDYGQGGGGGGGGMGPPGGEGLSMEYYSMTCPYAAEIVRDVVSAALAKDPTLAASLLRLHFHDCFVRGCDASVLLDSTKAHGTAEKDALTNKSLRGFEVIDAIKAALEAQCPGTVSCADVLAFAARDSVYMAGGPYYDVPTGRRDGSLSRADDTSALPAATLKAAELIKVFVGDHGFTVPELVALSGGHTLGQAHCANFKNRLSGFGKAGNGVDPTLEAGMAASLAKTCKAAGDGG... | 14 |
W1PX66 | 4.1.1.50 | ACT_SITE 63; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 77; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 233; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVSGFEGFEKRLELRFTGADPNGPGLRRLGQFEINRILEAAQCTIVSGLGNRFFDSYVLSESSLFIYPSKIIIKTCGTTHLLQSLSLFLHHAKKLGHYISSCTYTRGNFIFPESQPFPHTNFKEEVSFLENDLPPRLSERKSSVLRSKTSHSWHVYTSRDPNMLETGAQNEVYTMEVCMTDLDRSSARRFFRHENYLSGDEAGREMTERSGIGSIRANSVICDFAFDPCGYSMNGLLGSSYSTIHVTPENGYSYASFECVGLGLGQGQEMEEVAAVLARVARVFGPGTLSVALRAPQGAEWSIGEAATVLEPMGMALRG... | 196 |
Q8TTI4 | 1.8.4.12 | ACT_SITE 128; /note="Nucleophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_01400" | MHKGGLQLAQNKIEKSEEEWKKILTPEQYHVLRQKGTEKPFSGNLYYNKEKGVYTCAACGQELFSSDTKFESGTGWPSFYDAISSDKVRLKEDNSYFMHRIEVVCSRCGSHLGHVFEDGPVPTGKRYCINSVSLGFEKEEEAEREEK | 40 |
Q54MU9 | 3.2.1.52 | ACT_SITE 449; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MKRIITIINYLFLILLLLLLSFINLTFSFNIVNIEDFKIVNNNENLNYIFPKPKFVTFQASRGDPKNINEFDAKRPFIELTNETKIKFQNDEKSSSSSQNKKHWNENDIEHIKKYYQYLFKVYPIREQSNIFKDIIINNKNNYENTTGTTYTIEIIKTPTLSEKDYKSTHKNTIPFGSNENYELLSSQYGITIYVNSKFGVLHALKSLFQSGNLVLSNNNNNNNNNNNNNNNNNNNKRIKKLYFYNYPFSIVDKPRLNYRGLLIDTGRHYLSVEYIKEIITSMSLLKMNALHWHITDDQSFPLEIPEYPLLYRKGSNHLG... | 170 |
P9WPC3 | 3.4.21.92 | ACT_SITE 110; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 135; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MNSQNSQIQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERMRTLMETTLARHTGKDAGVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA | 179 |
C5XW16 | 3.1.1.11 | ACT_SITE 197; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAGGRWSLAALALVAMAVVSAAETWPPAPHAVVARKRPGDCRGVADAHCHGTIGEALKDEAAALRVTTGAKKGHVPRLVILITAGEYKEQVHITRRNVVLLGEGRGKTIISGNLSNRTGTEMYMTATVNALGHGFVAQNLTILNSAGPDGKQAVALRSNSHRSVVYGCSIEGYEDTLYAENGAQVYLDTDIYGTVDFVFGNARAVFQRCRIRVREPLSGKHNVITAQGCNNKTYQDSGFVFHRCTVEADPNPIRDPVSGEPIGFQNLTGVETYLGRPHRNFSHVVFMQSELGAIVHTDGWVAWDKNHVIKETTESVKYL... | 125 |
Q54B48 | 2.7.11.1 | ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 1474; /note="Proton acceptor"; /evidence="ECO:0000250" | MTGFEIFKKKYQVIQILNEINNNLEERLISIAKDKSGKLCVLKEIKYLNNKKKLEEFKKEEKNEEGIQKRIYQRNFNLEFNHLKNFSQMNHTSIIKYIEHIESKDEFGLVDRCIFVTEYYEDGDLSSIKEIEFKDIINLFLKMLINLKEFQNVIIHRDIKPENIFLRKFKNNDGKVELDCYLGDYGSAQTLYTQNKSTLIGTNQYIAPEVIEKKGHTNLIDIYSLGKTLLSLSKRNTGFVYNRIYLKLFEIMTNPFETRPNVNQLIEFMCRHHENLKYTLLVSDFQHRDSIKCLNYLKEKLIGILDNKTNPLKKIHIDME... | 99 |
Q0V9K2 | 3.1.1.116 | ACT_SITE 143; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 239; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 298; /note="Charge relay system"; /evidence="ECO:0000250" | MTLKLAVLRQIFQGSKGWHLWQHWRAFYSSSASGNGKLCCQTGTTDKNTHATRVVDLSYDLYDGSAPGPPLVLLHGLFGSKSNFQSIARALVRKTGRKVLTLDARNHGCSPHDDIMTYPAMSADVCQILHKLQITSCVLIGHSMGGKTAMTVALQEPKLVERFVSVDISPAATVPQTGFPHYIAAMQKVHLEGKIPRSTARRLAEEQLSSTVKEASIRQFLLTNLVQENGTFKWRVNLEVISQHLQDLLDFPEFQEPYPGPALFLGGANSPYISSENYPEIERLFPCANVEYIFGAGHWVHADKTHDFLNSICNFVESA | 126 |
Q9X2I6 | 4.1.1.17 | ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MMEYWIRRALEVVKTPFLLFDLSVVEKKYLEMKAALKKADIYYAVKANSHPRIISLLARLGSNFDVASKGEIEKLLALGVDGKRMSFGNTIKREEDIAFAYKNGIRLFAVDSEMEVEKVAINAPGSFVFVRVETDGADADWPLSRKFGTNPEHALQLLSYASKMKLIPAGLSFHVGSQNLNPESWKKAIEIAGRVFKKAMRSGLNLFLLNVGGGFPVQHTKPIPSMEEIGKAIEEAIDENLWFVHNLKVIAEPGRYMVGEAGWLVTKVLLKSERSGEKWVYIDAGVFHGLAETIQNFEYEIRVLGKEREELEEYHLAGPT... | 195 |
A0A804JAC6 | 3.2.1.52 | ACT_SITE 341; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MASKTFDPFALPCFLLLSLAASLLLSPSHGRIPHRRPASSSADDQLVYLWPLPKLFRHGYRTLSVDPDLALDLQIPGGESLALSEAFERYRDLIFTQWERSAQRSYMDYDVNKLTVLVASNDDTLQFGVDESYTLSVGGGESFSVVNGAAIEANTVYGALRGLETFSQLCTPNTENKTVEIQKAPWYIEDEPRFSFRGLLIDTSRHYLPVNVIKQVIDAMSYAKLNVLHWHIVDEQSFPLEVPSYPNLWKGAYSKLERYTVEDAYEVVDFAKKRGIHIMAEVDVPGHGESWGAGYPDLWPSANCTEPLDVSKNFTFEVIS... | 170 |
Q9P7V9 | 3.4.19.12 | ACT_SITE 50; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 375; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093" | MSLLRWMGMNSPGSTDRRKSTWEAELPKPSIRPETLTDRFYGLTNYGNTCYVSSVLVSLYHLKPFRDSLNSYPLPSAPPNFKSVCTKTNHPESSSSRHSKKKSMENRKSSLYGSNGINSCGCVDISNVGSESGTKHQIVVGESNCSAYGMKENIYTCLKDLYCSVSCCDCRYGICSPERFIQVLRRDNEAFRSTQQQDAHEFFNFLLNSVTETLDEYYGNHSDVMHPKWVHSLFEGTLTSETKCLTCENITSRDESFLDLSIDIENHTSVTSCLRSFSASEMLSSKNKFHCDVCKSLQEAEKRMKIKKLPKILSLHLKRF... | 175 |
I1L7K4 | 3.1.1.11 | ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVNGKILASGVSLILVVGVAIGVVVVVNRKGTSNPEVEAQQKSVKAMCEGTDDPKLCHDTLITVNSTNSSDPKAYIAAGVEATVKSVIQALNMSDRLKVEHGDKDPGIKMALDDCKDLIEFALDSIESSANLVNNHNIQALHDQSPDFRNWLSAIISYQQSCMDGFNNETNGEQEIKEQLHTGSLDQMGKLTGIVLDIVTNLSKILQSFDLKLDLNPASRRLLELDAEGYPTWFSAADRRLLAKMNQGGAPPPNAVVALDGSGQFKSVKQAIDSYPKNFKGRFIIYVKAGIYNEYITIPKKSENILIYGDGPTKSIITGN... | 125 |
A0A804KQJ9 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSFRGPTILVFLGFLSCVHADLKLGFYDDSCPKAEKMILDFVEEHIPNAPTVAASLLRMHFHDCFVRGCDGSVLINSTSTNQAEKAATPNQTLRGFDFIDRLKSVVEEECPGIVSCADILALATRDAVGVIGGPIWRVPTGRRDGLISNLTEALSEIPAPTSNLSSLQTSFANKGLNAADLVLLSGAHTIGVAHCESFSDRLYNFTGNGDQDPSLDGFYATNLKKNKCRDATDETTLVEMDPGSFRTFDVGYYRNLLKRRGLFESDAALTTDAAAKAAIVDLVDSPPQTFFAGFAMSMEKMGSIGVKTGSSGEIRRNCAV... | 14 |
A0A3Q7EX40 | 1.11.1.7 | ACT_SITE 30; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | TCPQSEDIIKEQVNQQQQNNAFSWLWNVFHDCFVESYNVSLLLELTSGMLSEMETDRSFGMRNFRYIDTIKEAVERESHDFVSCTDVIVLSGRDGIVAVRGPHIPLKTGRRHGRRSRADILEQHLPSHNGSLVLCLRGAHSVFFPQCIKLVQRLYPEVDPQLNPEHVHHILKKCPNSKAVHYVRNDRGTPMKLDNNYYRNILDNKGLMLVDQLAIDKRAKLYVKKMAKSQHYFFKEFSRAITVLSKNNPLTGTKGEIRKQYEAESINFILDYDPSLPFPQSLDYGLECYYK | 14 |
A0A9R1UK63 | 3.4.19.9 | ACT_SITE 226; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 337; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MITLLPAIVHSHFSHVKTQNTTNHRLRTPPSPMTPSHQPPPPPPPPSSPVSTASKHITTSNSASTSSPTPSDVWNYVWIPFLISLCKEVSSAKPSSESTNVLTSDSVSRLSSTCPTTDSKLNFRPIIGILSHPGDGASGRLNNAANASYIAASYVKFVESAGARVIPLIYNEAPEILQSKLNLVNGVLFTGGWAKSGLYAEVVEGIFKQVLKKNDEGDHFPLLAICLGFELLTMIVSKNNKILEQFSASDQASTLQFMTNIEGTVFQRFPADLLAKLSTDCLVMQNHKYGISPETFQENTKLCNFFKILTTSIDQDNKVY... | 176 |
Q96C23 | 5.1.3.3 | ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000305|PubMed:15026423"; ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:15026423" | MASVTRAVFGELPSGGGTVEKFQLQSDLLRVDIISWGCTITALEVKDRQGRASDVVLGFAELEGYLQKQPYFGAVIGRVANRIAKGTFKVDGKEYHLAINKEPNSLHGGVRGFDKVLWTPRVLSNGVQFSRISPDGEEGYPGELKVWVTYTLDGGELIVNYRAQASQATPVNLTNHSYFNLAGQASPNINDHEVTIEADTYLPVDETLIPTGEVAPVQGTAFDLRKPVELGKHLQDFHLNGFDHNFCLKGSKEKHFCARVHHAASGRVLEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGFCLETQNWPDAVNQPRF... | 211 |
O00102 | 2.3.2.23 | ACT_SITE 90; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MSKAMALRRLMKEYKELTENGPDGITAGPSNEDDFFTWDCLIQGPDGTPFEGGLYPATLKFPSDYPLGPPTLKFECEFFHPNVYKDGTVCISILHAPGDDPNMYESSSERWSPVQSVEKILLSVMSMLAEPNDESGANIDACKMWREDREEYCRVVRRLARKTLGL | 64 |
Q9S7I6 | 2.7.11.1 | ACT_SITE 996; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTSLPSSVIKWRFFRRQMPSDVVFSLCLLCFASCLAGKITVLADSDKSVLLRFKKTVSDPGSILASWVEESEDYCSWFGVSCDSSSRVMALNISGSGSSEISRNRFTCGDIGKFPLYGFGVRRDCTGNHGALAGNLPSVIMSLTGLRVLSLPFNSFSGEIPVGIWGMEKLEVLDLEGNLMTGSLPDQFTGLRNLRVMNLGFNRVSGEIPNSLQNLTKLEILNLGGNKLNGTVPGFVGRFRVLHLPLNWLQGSLPKDIGDSCGKLEHLDLSGNFLTGRIPESLGKCAGLRSLLLYMNTLEETIPLEFGSLQKLEVLDVSRN... | 99 |
Q4Q837 | 2.3.1.48 | ACT_SITE 334; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MAVAQSAFGNGTEDSAVLSSTPDTAAAPYGLADGMAQLSRVLHRPWLSGVYMEVTPGMARTQRARRQLDYLEERLLRDCRTPTTVRYFVYLNTYVFAPWYYAPFGLLNSEYDPMLPWTGAADASTGAIPAGEGADATGSSVGVQQQQQPFIRDAFLCPFSLRIYSTYAQMHYETRTYRAGRLRPPGEEVYRDEVRGLSLFKINGSQHVTYCRHLFLIGKSFLENKLAGHDVHNYYFYVVCLHHRYFPDYVSDPSAMYFAGFFTWEKHVSEYNLACIATLPCFGRRSSRQRPVASPAGSTAAASRPPRVLRHLGQFMIAAS... | 61 |
Q9JZ53 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 337; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYSGKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEATEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLTEKLGGRVQLVGDDLFVTNPK... | 200 |
A0A3B3I798 | 2.3.2.26 | ACT_SITE 763; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MSNQGVRRNGPVKVRLTVLCAKNLAKKDFFRLPDPFAKVVVDGSGQCHSTDTVRNTLDPKWNQHYDLYIGKADSITISVWNHKKIHKKQGAGFLGCVRLLSNTINRLKDTGYQRLDLNKLGPNDNDTVRGQIVVSLQSRDRIGTGGPVVDCSRLFDNDLPDGWEERRTTSGRIQYLNHITRTTQWERPTRCPEAVRDGEETGNGDKYRPASEYSSPSGRPSSCVVDENTPVMTPVNGAVASCPLGEQRVQERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNVNCEELGPL... | 65 |
A7E5H2 | 1.11.1.6 | ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 140; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MVADEKPASTFRYDEAPVYTTSNGCPVRHPEEFQRIGNNGPLLLQDFHLIDLLAHFDRERIPERVVHAKGAGAYGEFEVTHDISDITTIDMLSKVGKKTPLVTRFSTVGGEKGSPDSARDPRGFSVKFYTEEGNWDWVYNNTPVFFLRDPTKFPLFIHTQKRNPQTNLKDATMFWDYLSTHQEAVHQVMHLFSDRGTPYSYRHMNGYSGHTHKWFKPDGTFNYVQVHLKTDQGSKTFTNEEAGKMASENPDWHTQDLFDAIEKGDYPSWSVYVQVLSPEQAEKFRWNIFDLTKVWPQAEVPLRPFGKMTLNKNVENYFAE... | 13 |
A0A059D5R2 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 127; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 142; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MEGASNGGMLYHEVQESKLCAVHCVNTVLQGPFFSEFDLAALASDLDRRERQMMMMPVPGVGGVGGGDFLSQESHNVSLDGDFSIQVLEKALEVWDLQVIPLNSPVAEPAQIDPELENAFICHLQDHWFCIRKVNGEWYNFDSLYAAPQYLSKFYLSAYLDSLKSSGWSIFLVRGNFPRECPISSSEAPSGYGQWLSPEDAERIIKSCNTTQPPPPPQRSQTDHTLSDMEAEELEAAIAASLMDTPAATPQVSEVATPQASEAATTQAEKETR | 175 |
A0A2K1IEY0 | 3.1.1.11 | ACT_SITE 213; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MWGRSIKPKLRWDRGSKEAADPLDSSNNNNSSSSSFNAGIEAVDAMQDLPRDGSLRVAQDGSGHFRTVQAAIDSLPLPNNKRVVIWVAPGVYRQPVYVPKQKKLITIRGEDAHKTILTWANTATSIQHDLSSQVIGTGTFACGTVIVEGEDFIAQNITFENAAPKGSGQAVAIRVTADRCAFYECRFLGWQDTAYLHYGRQYFRNCYIEGSVDFIFGNAQVLLEYCHIHCKSDGFITAQSCKSPDEPTGYVFLRCVITGTGTRPYMHLGRPWQPCARVIFAFTFMDGCIVPAGWNNWNDKEKERTACFYEFRCTGPGSDV... | 125 |
A0A1U8IIS3 | 3.1.1.11 | ACT_SITE 393; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSNKVVVAGVSIILVVGVAIGVVTTINHSRDAKGKLSPEMKVATSICSPTHYPDACHKTFASMNSTGPKEFVKKVIYAAEEEVKKFLNFSDSKIAEAKDNGLTKMALNDCKDMMQYAIDSLKATYADVDGSDLHNIDDRINDFRTWLSAVISYQQSCLDGFEHDSSWRETMEEAIVASSEQAANALTIVTKLIEILTKLGSELASPNTRRLFSVEETNYPSWFSTTDRKLIAKIDNSNLKPNAVVAKDGSGQFKTIAEALAAAPKNSINRHIIYIKAGIYDEYITVDKQYTNILMFGDGPRRTIVAGRKGVKDGGGITTW... | 125 |
C5XMB6 | 1.11.1.7 | ACT_SITE 85; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALRQQQQQLLVVVVVAAVVVASCRPGRADPAAMSVLPGLPVAGLAVGFYNESCPQVEDLVLAEMQSLVGKDKTIGPALLRFMFHDCLVRGCDASIMLISRNKTGERDAIPSYGLRGYDEIEHIKAKVEDACPLTVSCADIIIMAARDAVYLSNGPRYAVETGRRDGKVSLDCDANNDLPPPSSAIVDLKTYFSFKGLGWKDLVVLSGSHTIGRAQCSTFASDRLYNYSGRVAQDPSLNKTYAAHLRELCEPGVANDAAMVEMDPSSPYTFDLSYYRAVRGNTGLFTSDQALLDDPWTRAYVERMAAAGASTDEFFADYA... | 14 |
B6K5Y4 | 3.1.1.5 | ACT_SITE 1055; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 1174; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MEDTTISASNNLFALSIRLTARVITWGLVQLTRLSLDVLSFCTITLPKWTYKIVSLTLTVQLNFRSIVILFFIFLACVLVVIRYRYLNKYSRLPAESPIEEAKLDIDEGPTTANSKVNSIQTYLDEFLSAIRIFGYLEKPMFMELARYMETRRIAEGETIVLAKETSFILVVDGCFQVFVKNERGNQDDAFSDTDIEKNYSLLTEVHNGAPLSSLFTILELFTELVSDNDEPVQGKSESQASSPLTDTLKEKRESKAQRKLRSFYVVARAKVDTTIAVIPADAFRRLIKKYPKAGAHISQVILTRFERVTFSTGYYYLGL... | 131 |
A0A8M3AW15 | 2.3.2.26 | ACT_SITE 1443; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAPQGRDHLATRESAGRRRSPNVRHTLSPENLRSLAERGGAEQAGVGLLRANSDTDLVSSQGRSSLTASTLEFTLCRGQNLVISWDIKEEVDATDWIGLYHIDETCPSNVWDCKNRGVNGTQCGQIVWRLEVGPYFLESETRICFKYYHGVSGALRATTPCITVKNPRASVDGQGEGQQASDSSRKLVSFTLSDIRAVGLKKGMFFNPDPYLKMSIHPGKRSCFPTFSHHGQERRSGITTNTTNPVWHGEKHTFVALMTDVLVIEVKDKFAKSRPIIKRFLGQLNIPVQLLLERHSTGNQSLSFSLCRRLPTDHVSGQMH... | 65 |
A0A8V0YWW2 | 2.7.10.1 | ACT_SITE 743; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MGIPPLNVCGNPLNKWGGRTEMSPRLINPPHKVVLLDFAKAQGELGWLTQPYGKGWDLQQHVLNDTGIYIYAVCSVLQGEQENWLRTNWIYRSEAQRIFIELKFTVRDCNSFPGGGGSCKETFNLFYAESDVDYGTNFQKRQFKKIDTIAPDEITVQEDFETRNVKLNVEVRSVGPLHRKGFYLAFQDLGACVSLLSVRVYYKTCPAVLRGLAVFPETVAGADSQQLAKVQGACVENAVADRAPMLHCNMDGEWLVPIEQCQCQAGYEAAGEQCQACPPGTFKAEVSLSGCQPCPAHTLPSSAAADACPCQDGYFRAPTD... | 97 |
P80366 | 3.1.3.2 | ACT_SITE 323; /note="Proton donor"; /evidence="ECO:0000303|PubMed:7770774, ECO:0000303|PubMed:8683579" | MGVVKGLLALALVLNVVVVSNGGKSSNFVRKTNKNRDMPLDSDVFRVPPGYNAPQQVHITQGDLVGRAMIISWVTMDEPGSSAVRYWSEKNGRKRIAKGKMSTYRFFNYSSGFIHHTTIRKLKYNTKYYYEVGLRNTTRRFSFITPPQTGLDVPYTFGLIGDLGQSFDSNTTLSHYELSPKKGQTVLFVGDLSYADRYPNHDNVRWDTWGRFTERSVAYQPWIWTAGNHEIEFAPEINETEPFKPFSYRYHVPYEASQSTSPFWYSIKRASAHIIVLSSYSAYGRGTPQYTWLKKELRKVKRSETPWLIVLMHSPLYNSY... | 145 |
A9VDG6 | 2.7.11.1 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MSGEPKREWTLNDFEIGKPLGRGKFGNVYLAREKRTKFVVALKVLFKSQLQKNNVEHQLRREIEIQSHLRHPNILRLYGYFYDESRVYLILEYAAQGELYKKLQEYGRFSEPTTANYIKQLATALEYCHRKHVIHRDIKPENLLLGLKGTLKIADFGWAVHTPSSRRRTLCGTLDYLPPEMIEGKAHDANVDLWSLGVLCYEFMVGNPPFEAEGHRDTYRRIVKVDLHFPDYISEGARDFVSKLLQHDPEKRMRLDMALQHPWLVSQSQSFSD | 99 |
Q5QMT0 | 3.2.1.21 | ACT_SITE 215; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 424; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MGHRLVVVLLLALLVAGAARAAEQAAGEDGIRGGAGADHQEAAGITGGLSRRSFPAGFVFGTAASAYQVEGMALKDGRGPSIWDAFVKTPGEIANNATADVTVDEYHRYKEDVNIMKSMGFDAYRFSISWSRIFPTGTGKVNWKGVAYYNRLINYMLKIGITPYANLYHYDLPEALEVQYGGLLNRKIVEAFADYAEFCFKTFGDRVKNWMTFNEPRVVAALGYDDGNFAPGRCTKCTAGNSATEPYIVAHHLILSHASAVQRYRHKYQHIQKGKIGILLDFVWYEGLTNSTADQAAAQRSRDFHVGWFLHPIIYGEYPK... | 161 |
Q95UN8 | 2.7.11.25 | ACT_SITE 264; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q02779, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPSQVSRGLDTTNMLPISEEQQLQQQQQQQQLEQLHHPQIPEIPIPDLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVS... | 105 |
F4NYW4 | 3.1.3.16 | ACT_SITE 217; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MIDSSYIKGYYRRAVGNIALGKLKDAIKDLRTVVKSTPQDRDARTKLAQCEKEQKRIEFEKAIGFEENKINILDRIGNVDEIIVDDSYDGPHLDIKSGITLEFVKNLLEYMKNQKKLHRKYTLQILIAVKALFEALPPIIDITIPADGKITVCGDIHGQYYDLLNIFDNNGLPSPTNMYLWNGDFVDRGSFSVECIITLFSFKLLYPHAVYLSRGNHEADDMNKVYGFEGEVKAKYSELTFRLFSEIFNAVPIGNLINEKILVVHGGLFSRDDVTMDDLRKIDRFKQPGHEGLMCELLWSDPQPEMGRSASKRGVGIQFG... | 144 |
Q9VXE5 | 2.7.11.1 | ACT_SITE 487; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:O96013, ECO:0000255|PROSITE-ProRule:PRU00159" | MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGIVLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSASRASSSSG... | 99 |
A0A1S3XCW1 | 3.1.1.11 | ACT_SITE 397; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVGKIVVSLVSLILLVGVIVGVVVVVHKNGDNDDDKSTKVQMKKVDEFCQPTSFKDACVQSLDKVASNDSATIKDYIMAAFEYTVQEIKKSLHETGKTNVNKESDPYNHMAVEDCKVLLEDAIEELESTLKKVSENEMKSLNDKVYDILTYVSAVYSYQSECIDSIDKPEYKSAIEKYLVNSTQLSNNAIDIVAKISSALQSSGFQIPDGLLNRKLLEANYQIGHDNYPTWFPVADRKLLANTPTPHAIVAKDGSGKFKTVSDALKAYPQKHQGKYIVYVKAGVYNEQVLVDKKQPNVFIFGDGAGKTIITSDKNVAILK... | 125 |
G2WSP8 | 2.1.1.37 | ACT_SITE 872; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MPYFIYDDVDTSADDSSSTHSREVNGIPNSEDAYSGDTEGIIDDGYWPEVDDEWLPDGRRSSAPHDEDDDAATLQPGDPLPWENDEIGLVQDERGKTLGRLLSPSVDTLAKSRGFTVAIPESTLVHPVSSFSGFCAPAPERKEKCAVEALLKNPVSLPKDEFFEIELGQFVVYRHSASDRDKPPHRRQYPYEMRPLQTLCTKGAHSTLYADGILSHGDAKFFVRGIAFEELPLGNYGMAEPTVGDQIWISSTLNQRMGKQNLYYKLTTPAKEYARYHHGFLWVADLAKHVVDYMAAAGDKKRRVEFRHFKSHFHRWLIQA... | 47 |
P09124 | 1.2.1.12 | ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHLLQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTKRADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPFAKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSLVLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYSEEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYS... | 22 |
A0A022QH33 | 3.1.1.11 | ACT_SITE 74; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | VYGERFVAIDITFQNTAGPHKHQAVAVRNTADLSIFYRCSFEGYCIPTNSYQDTLYAHSLRQFYQDCNVYGTVDFIFGNAAAVFQSCNLFARNPKNRVHRTRPNGSESKYRDIHPQLHYNYLGRPWKEYSRTAYMPSYIGDLIDPIGWLEWNGTYGKDTLYYGEYGNYGPGAGTSMRVTWH | 125 |
Q8ZXR6 | 5.4.99.12 | ACT_SITE 43; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MPYLYRIAYDGTMFYGFTGHPNSLEPRLRLIFGEILGRGSRTDPGVSAVGNVVMTGRKMALGYVNSKMPKGAWAWGIAEVPEGFNPRRAKLRRYLYVAPHWGEDVDVMREAAKLLTGTHDYSSFIQLRGEKHTPTVTTVYDIDVTLRGDLIFIYFAGRGFRNKMIRKMAWALLAAGRGVLSVDDLADLLKKPRPGAVPSAPAEGLVLLDIVYDVKFEVDFSALRKAYVYFLSKSRHLSAHAAALRAAGEALAMWES | 217 |
Q7ND22 | 2.3.1.181 | ACT_SITE 170; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013" | MGRCLLIEPGLVPYLTAWEWQRQLMATRIAHRDRPDVLMLLEHPPVYTLGQGADAKHVLVDPASIELYRTERGGEVTYHGPGQLVGYPILDLTGYRQDLHWYLRTLEQVLIEVLADFGVQGEREAGFTGVWAGGRKIAALGIKVSRWVTMHGFALNVDPDLDAFARIVPCGLTRPVGSLVQLCPGVSVEQVQPVVACAFARVFGVQCEPGALEACLAVKPGC | 55 |
P47312 | 2.2.1.1 | ACT_SITE 397; /note="Proton donor"; /evidence="ECO:0000250" | MKYLYATQHLTLNAIKHAKGGHVGMAIGASPILFSLFTKHFHFDPDQPKWINRDRFVLSAGHGSMALYSIFHFAGLISKQEILQHKHGQINTSSHPEYAPNNFIDASTGPLGQGFGMAVGMVLAQKLLANEFKELSDKLFDHYTYVVVGDGDLQEGVSYEVSQIAGLYKLNKLIVLHDSNRVQMDSEVKKVANENLKVRFENVGWNYIHTDDQLENIDQAIIKAKQSDKPTFIEVRTTIAKNTHLEDQYGGHWFIPNEVDFQLFEKRTNTNFNFFNYPDSIYHWFKQTVIERQKQIKEDYNNLLISLKDKPLFKKFTNWI... | 51 |
A0A3B6TKQ0 | 1.11.1.7 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MPPGQPYPTGANNTRRTRPSKKMATKLAALIVLVAFLAGPPACEGDIICFNGWLKLPIQDPRLCPQGSMSRMNGRTRALVPVPRPSGLGLGLGYYNNRSSRSYCPRAEGIVRDAVSKAVAAQPGIGAGLIRLFFHDCFVRGCDASVLLTTTNSNNSDTEREGNPNKNSLRGLEVIDAAKAKIEAACPGRVSCADIVAFAARDASSILSNRRINIRMPGGRYDGRESFSNETDQLPGPFSGATVLLSNFKAKGLTSDEMVTLSGAHTIGRARCAFFSSRFSEMDPTFAAKLKAQCNDDDTNVDQEHVTPEVLDKRYYQDVI... | 14 |
F6H6V9 | 3.1.1.11 | ACT_SITE 421; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGYNNAADADSRGKKKVALMGFSSILLVAMVVGTVVTVNHRNGSSSSATDDAQAGGGISTSVKAIQAICQPTDYKEACVNSLTSAKANTSDPKELVRTAFQVAINQISSALQNSTTLRDLEKDPRTKGALENCHELMDYAIDDLRNSFNKLGVFDISKIDDYVEDLKIWLSGALTYQETCLDGFENTTGDAGEKMKALLKSAGELTSNGLAMIDEISSVLTNLQIPGISRRLLSDESGKGEYRSDEGGLYPSWASVGQRKLFQATPDTIKPNVIVAQDGSGKYKTINEALVEIPKNGNTTFVLYVKEGVYKEQVNFTKSM... | 125 |
Q8ZUR4 | 2.3.1.181 | ACT_SITE 161; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013" | MKILWIGRTQYAEAWRLMKSLHCAVAQGLTGDIALVTEHEPVVTVGKHGRLNNVIKWDVPVYLVERGGDATYHGPGQAVVYPIVALRWPLKRYIDAIEDAVIKTLGTYGILAGKKQGHRGVWVGDRKIASIGIAVENNVAYHGVAINVTIDPREFARINPCGLPASTMISMKELGVVAEVRDVGIETAKKLALELGLTPELISKPPEVPQVAEELKPVRVAINA | 55 |
Q9LR78 | 3.1.3.16 | ACT_SITE 577; /note="Proton donor"; /evidence="ECO:0000250" | MAPDQSYQYPSPSYESIQTFYDTDEDWPGPRCGHTLTAVFVNNSHQLILFGGSTTAVANHNSSLPEISLDGVTNSVHSFDVLTRKWTRLNPIGDVPSPRACHAAALYGTLILIQGGIGPSGPSDGDVYMLDMTNNKWIKFLVGGETPSPRYGHVMDIAAQRWLVIFSGNNGNEILDDTWALDTRGPFSWDRLNPSGNQPSGRMYASGSSREDGIFLLCGGIDHSGVTLGDTYGLKMDSDNVWTPVPAVAPSPRYQHTAVFGGSKLHVIGGILNRARLIDGEAVVAVLDTETGEWVDTNQPETSASGANRQNQYQLMRRCH... | 144 |
Q557H5 | 2.3.1.225 | ACT_SITE 329; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250" | MVNNNNKNNKINDRENEENEKNKKKDKIYENKIGINENNNENNNYQNENFIYTSGDSNDTQEGDISEIQEESTNENNKKLKKRKIKKTKSLYFYKCVTGPDKLFFIVTQIFILVPSLFFEIKLVPISLEISKKLEISNYIITLTLLVFIFYNLYKCAFTNPGIITRNNIEESKKDKIKLTKLQATKKALKKFITSGMDEIANDDPISSSSDFSDSDDDDQDEQGGSSSARNSFENSGDFIVEMEQPTNSNNNNSNNNNNNNKNRNRNNNNNNNNNNNNKNQSKYKEIQIGDSDFKYKCKFCITCGLYREPRSFHCSTCNN... | 57 |
Q55637 | 3.1.26.3 | ACT_SITE 54; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 125; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MSLLPHRQTQLKALLRRLGLTDNTPVDWNLVDLALTHASQSPEQNYQQLEFVGDAVVRLASAEVLMKHYPQTSVGEMSALRAILVSDRTLAGWGELYGLDRFLWITPAVLADKNGRVSLMADSFEALLGALYLSVGDLSLIRPWLSEHLLAKATEIRQDPALHNYKEALQAWTQAHYKCLPEYRVEPLDQNLPQQSGFQATVWLGDQPLGSGSGSSKKSAEQAAAQQAYQDFIAKEILPMPKIN | 138 |
A0A078HPP7 | 3.4.21.89 | ACT_SITE 147; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 197; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MRMISLDFPTPSLSLLTSDSNSRFYKNASNNPIIRVNFTKKSQSVSLPRLNFRETHSNRRNLSCHGIKDSSETTKSAPPLDSGGGNGGGGDGGDNGDDDSEVEGKNRLLPEWLDFTSDDAKTVFLAITVSLAFRYFIAEPRYIPSLSMYPTFDVGDRLVAEKVSYYFRKPCANDIVIFKSPPVLQEVGYTDADVFIKRIVAKEGDLVEVHNGKLMVNGVPRSESFILEPPGYEMTPVRVPENSVFVMGDNRNNSYDSHVWGPLPLKNIIGRSVFRYWPPNRVSGTVLEGGCAVDIQQ | 178 |
A0A3B6SQR4 | 2.3.2.26 | ACT_SITE 865; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MPPQNKSRKLHGEAADFFGQLFFFFDAKLDDDVDILCQVCGMLLQYVKCDAGGLVSLFATVDYSEVGPSVIIRVRKFLHMCIDALYVKRFQLVNQPEASSESDLMPFVQLLRTAICLLSHKLPWNCEVIGYLHQKKVFCLFREIIMVVVQNERQLKHRDFLSALYEVLALVASHVGNHPCSCVLLDPKWSFSSQILTIPFLCHRLPEFMKVLSADEFKTEYMYQIACADVLPNDTLANHPGQAYVLSNVLDIATLIFSESGFDSDRAAGIINFCTSLLDAFPKIASSIQSTHVDGAMPIEADDFNHLDVDLQRHILTSVE... | 65 |
A0A287AB45 | 2.7.1.11 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MAHHDDSQNPKGSFRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIVEADWESVSSILQVGGTIIGSARCKDFRSREGRLKAAANLIQLGITNLCVIGGDGSLTGANIFRREWSGLLEELAKDGKIDKEAVQRHGHLNVVGMVGSIDNDFCGTDMTIGTDSALHRIMEVVDAIMTTAQSHQRTFVLEVMGRHCGYVRAGTAGGERSPRMDPGHSVPQRPCPRKGPRGRPSRSLLCLCRYLALVSALACGADWVFLPESPPEEGWQEDMCIKLSENRARKKRLNIIIVAEGA... | 84 |
U5DIN5 | 3.2.1.52 | ACT_SITE 72; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MLQGIPPHGQQHTLRLRLWPAPTCSGKDPLALQPGTGHLNPLHPNTYPLLRKVLRDLAALFPDSFLHAGGDEVVPVYFQDVLVSSTINAKPELLPKETTILQSWSNGPHNTKLITSSGYRAIVSSSAFYYFDCGHGDFLGNDSSYDRRGDEGNGGSWCGPFKTWQRIYDYDITNGLTTKAAKLVLGGEVALWPEQADGTVLDARLWPRTADFAEAMWSGNWGETGMKRYAEATDRLDEWRYRMVARGVGAEPIQPQWCLKNPGMCNLNQ | 170 |
P48965 | 3.1.3.48 | ACT_SITE 432; /evidence="ECO:0000250|UniProtKB:P30304" | MELGPEPPHRRRLLFTCSPTPAPQPTGKVQFGASRAGGLSPVTNLTVTMDQLEGLGSDYEKPMDVRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPQKLLGCSPALKRSHSDSLDHDIFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESDISESGNFSPLFTPQSPVKASLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADRCGLFDSPSPCSSTSSCSTRAVKRADRSHEESPRGTKRRKSSEASPVKADVPEPTQLPHQSLSLT... | 149 |
Q9FCA2 | 3.5.1.88 | ACT_SITE 147; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MRQGSIPGAHGRVRPLGLLGDPVLHARCAEVTDFGPELAALVEDLFATMYAAHGVGLAANQVGEAVRVFVYDCPDDEDERHLGHVVNPRLVETGGVVVRGPEGCLSLPGLEAGTERYDEAVVTGFTVAGEPVTVRGTGFFARCLQHECDHLEGRVYADRLTGRRHRKLMRQVARASWHR | 183 |
A0A8V0XNF4 | 2.7.10.1 | ACT_SITE 871; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MGVRSPLSASGPRGAAVLVLLLLLLGRVALCSAVEEKKVCQGTNNKLTQLGHVEDHFTSLQRMYNNCEVVLSNLEITYVEHNRDLTFLKTIQEVAGYVLIALNMVDVIPLENLQIIRGNVLYDNSFALAVLSNYHMNKTQGLRELPMKRLSEILNGGVKISNNPKLCNMDTVLWNDIIDTSRKPLTVLDFASNLSSSCTHCPLSYHWMSLRGAWILEPCPKCHPNCTEDHCWGAGEQNCQTLTKVICAQQCSGRCRGKVPSDCCHNQCAAGCTGPRESDCLACRKFRDDATCKDTCPPLVLYNPTTYQMDVNPEGKYSFG... | 97 |
A0A3Q7EN60 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRKHFLTISLILFSLALPIFSELNQSACKSSLYPKLCRSLLSAFQHSPSNPNDDYSKFSVKQCQKKANKLSSLIAHFLSTQKQRSLFVNPKEISALTDCQQLTQLTVDYLNSISAELKKADVSTTSEDLVGKIHTLLSAVVTNQQTCYEGLKEAGSSMVDELLAPLSNAGEIYSVSLGLVTHALERVRKSRKSGRLLAEQGGVMEEEWARRSRFMASKVKQALERSHQRDGRILDELVENGVHIKETVTVSPYGGCNFTSIGEAIAFAPNNSMIDDGYFLIYAKEGYYEEYVVVAKNKKNIMLIGEGVDRTVIAGNRSVI... | 125 |
B3RPH2 | 2.3.2.26 | ACT_SITE 652; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MQPGIVLGAKHLAKKEFFRLPDPFARIAVDGSGQCHSTDIIKHTLDPKWNQNYDLSISKHDSITITVWNHRKIHKRQGAGFLGCVKIVANAINQLKDTGYQRLALGKSNQRDDCTVKGEIVVSLRSRDRVLSSPGIPQYSIQNSNLFRGRSSANPNKHYSGTSSPSNQHAPYNGNCAVSNTIPNSNHSSRGLQKPGEENAIRLSVQQVPTSERYDLRNRHQDRNQIHQPTIADSLLRTGPLRNSHDLAGNLGELPPGWEMRHNPNGRIYFIDHNTRRTQAIDPRIAIKSDQTEERGSLHPKIDLVQKWRNLKSDLSTLQP... | 65 |
Q86YW0 | 3.1.4.11 | ACT_SITE 170; /evidence="ECO:0000250|UniProtKB:P10688, ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 215; /evidence="ECO:0000250|UniProtKB:P10688, ECO:0000255|PROSITE-ProRule:PRU00270" | MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQ... | 153 |
A0A7M7LTF2 | 2.3.2.26 | ACT_SITE 943; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MADETTTVFKYLSRLLLCILIYVVLKTAFSQLFSSEEEAPFQTWLKGNELTHLEKQLRDAGCVSVEEAAQLDVNQRALRRLKQRDKEHLESAIEDLQDQLLLNQWLEDYSSLSLLPKLDDLDITAYSELHKVLDLDLDDITQDDEDPLKSIAVYLELNNLQRAVEKQMASDRPYELDFSLARRMWSGITHFVQTFGNVTLATLICAVGFAWVNGNYRTAQASGVSSRSRNAPIIDYITGSLVDPCGCLVDWGWEGSVPVGDTMSFTIKFYQRNGMKYAISDADQLAIEILVGQQRMACSVEYSETDYNLVKCAFTVRRSG... | 65 |
K7MD49 | 3.1.1.11 | ACT_SITE 529; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSTPPMPFLFLFLFSLIVPLLLAQAPSPSPTHSPPPPSPSPSPKHTPPPPPSTTTPPSPKHVPPPPPSSPSPSPKHAPPPPHSSPLPSPKHAPSSPPPSQAHAPPLPSSQSPPPTHSPPPSSPSPPSPTHAPPPSPTPPPARAPSPPPPPPPSSPSSACKSTLYPKLCRSIVSSIRSSPSDPYNLGKFSIKQSLKQAKKLVLVFKDFLTKYKSSSSLNAAEIAALEDCSELNQLNVNYLESVSEELKSADSSNDTELVEKIETYLSAVATNHYTCYDGLVVIKSNIANAIAVPLKNVTQLYSVSLGLVTQALKKNLKTHK... | 125 |
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