Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A3B3H6M1 | 2.7.11.13 | ACT_SITE 730; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000552-1" | MLQAASRPEPALQMANASPCLTPGVAPQAFFSPGSPLPPSPPLPMPPMVGFPITDMVPGQCSDESVMPSLPPAPPGVSFIIQIGLTRESVLMPQSADLAYVKQIACSIVDTKFPECGFYGIYDKILLFKHDTTTNNILQMVKATSDIQEGDLVEVVLSAATTFEDFQIRPHALNVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSTTSLSSSQSMRLSNTDSVNSSGMASTCGEDASLIRSNTQMPRTPSEARRFYTGRPVHLDKMLMSKVKVPHTFAVHSYTRPTVCQYCKRLLR... | 100 |
A0A1B9GEF8 | 2.1.1.37 | ACT_SITE 557; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MSPLTEIIEIGDSDSDIESIDITSRSNSTSTSRSICEYNESGRKRKRDDEIENISSDEEEVEIRSQLRELSVQVEASNLKDKQKASYISPPAHPCPPPATASKRHKSHSANRPMSSPARQHGLSTSRASKAGKAQLTWLKEDAITPARAIKRSTYKVNGFEEDCVRIYREGFHHDGDEFTVDDAILLPHSPPLYILIRSIFTLKFDDPVIHDRHLVHVHLFKPPVSGGRKGELFLRNAQCQDIPIKQILKGKKLDFELIGGIRRRGRGDSEYFCEFVDQSSLSTIREPKFQDRFHNCDSCLSRHQKHRFDHPYISNDTLH... | 47 |
E9G227 | 2.7.11.1 | ACT_SITE 752; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MNVEEEESLEVRQRNEIQALQAIFTSDFVAVNLSSNSEKWSPPEFILLLKPQKGLSQDEVHATVQLRVKFPCDYPQSYPSIKLENGEGISSKDIEKLQLELEQLCKEGVGEEVTFNLAHHAQGFLAERNQKPRFQSFHEEMLAAQRNNMEKSVLEEKSRQVREDEQQLIAFCEEIQKKQPALLSELRRITNLDPNQLPFLEINLGSSQTSNTNEDQSNLDHTIEAQKLCTHPKVQKISFSNKDGGRIYYCGPCLGVCRPNRYICAGVEPNLKEAATITTFQISCGNLESRRKQISLVEQEFRLLQRNVHHSALIPLLAFK... | 99 |
A9VB95 | 2.7.11.23 | ACT_SITE 148; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MATTVKGSRPAGKKGSGAKKAGYEKVKYLGEGQFGTVYLERDSQTGQLYAIKRIRLGDKSMAKEGLNQSAFREIMFLREVHHPNIIDLHDVFLKKGNLHLVLELASTDLEKLIRNKRLDFAPGDVKSLLLQTYQALDYLHARWILHRDLKPNNILITTGGQVKLTDFGLACTFGSPSREMTTQVVTIFYRAPELLLGARHYGVGVDIWAMACIHMELELRTPILPGDGPFDQLDKIMAFLSSFGHAFAQPNYRELSSSWEFKPRDPTPIRALLPAVSDAAIDLLEKQFTYDPLKRPTARETLMHPYFSEAPGPTPPDQLP... | 103 |
A0A8N7TES9 | 3.2.1.35 | ACT_SITE 165; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MSERTGVLNGFSQIRSEMKNITHLSGTTRTQRASWLQVLLLMLFWTCLKAQQLKNTRWPLYSGKPLLLAWNAPTEDCRPRHDVTFQLDQFQIVASPNEGFTKQNLTIFYQDRLGLYPYFKPDSTPVYGGLPQAASLTQHLEKMPDGLKKYIKDQAVKGLAVIDWEEWRPLWIRNWGPKLIYRDRSQRLVAEKNPTWPLDQVTKVAQQEFELSARKFMLETLRLAKSLRPQQLWGYYLFPDCYNHNYQTNLQNYTGQCPDIEVSRNNELKWLWTESTALYPSVYMGKILKDNPKGRQFVRNRVKEGMRLASVGDGSARPVF... | 166 |
A0A2I4FHY6 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTSTGTAMALALGLIFVSLAGRQSYAGSSAALEVGFYKGKCGIFDVESIVAGLVKAKFFKDPTIAPALIRMQFHDCFVSGCDASLLLNGGSSERFASPNLSVRGYEFIDEVKDAVESFCPGLVSCADIIAIATRDAISLSGGGRYRVETGRRDGFESLAENVDLPGPQIPVSESIAAFARKGLNVTDMVYLLGGHTVGVAHCFFFQDRLYNFQNTGRPDPTMDLELVRSLRSRCPQKSTGNNIVSLDQNFLSSFIVDNSFYQEILRKRGVLQIDQRLALDPRTRDIVTTIASGRASDFGSKFGEAMIKMGAIQVLTGTEG... | 14 |
H2XYT3 | 2.1.1.33 | ACT_SITE 159; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MDEIENEIISKKLPRKKYFRQRAHSNPLGDHNVEYPISPRTMDWSKHYPAYFVNEKSENNEMESDDMTVRKVEVLDIGCGYGGLLIALSKLLPDTLITGMEIRVKVSDYVQERIQALRMAHVGTKEFQNVACIRTNAMKYLPNFFSKGQLKKTFILFPDPHFKKQKHKWRIVSSTLLAEYAYILCQGGLLYTITDVLEVHEWMVKHFSEHPLFDRVDDHELKDDACYKAMFVSTEEGKKVARNNGEKYPAVFRRNDFGFAGKSS | 45 |
A9UMP7 | 4.2.1.11 | ACT_SITE 468; /note="Proton acceptor"; /evidence="ECO:0000250" | MSYRVTGDAARKARERYELKQAAAEFYRKRNVPERLEEALNSTFCLGPEDVYGHLANYFAQFSMPPTICQIRGRKVLDGSGEPTVEVEVSCTVKNSDKRICSSVISAVSEHPKASEGLEQERNHSADTAIQWLKDLSPLLKGMSPNEQHNIDQLLSDFYQPKIEEEKARRQMEREASPMAIEPVPSPVTSPALGKKKGSGKGKKAVVMEKPIPPKEAPEPVVPGSPAIGALSLAVAKASSVLGKTPLYLHIATLRNEKLPSEFIMPTPMISVLSCGKSSPGKLNLMKEVLVIPPTGLTVQQSLDMALMLQNQIVKQINSI... | 200 |
A0A1B6QF74 | 6.2.1.5 | ACT_SITE 330; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222" | MDRETHPRRVPEDKGRRGAPSQKPARNRIESGEGKKKKRGRARAAAMAAASSRRASQLLGSAASRLLHARGFAAAAAAAPSPAVFVDKSTRVICQGITGKNGTFHTEQAIEYGTNMVGGVTPKKGGTEHLGLPVFNSVAEAKAETKANASVIYVPPPFAAAAIMEAMDAELDLVVCITEGIPQHDMVKVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVDDPQTEGIVLIGEIGGTAEEDAATFIQESKTQKPVVAFIAGL... | 247 |
F2DP54 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASRAAAALVVVAMACAVVHSAAAAAGELSPDFHAGSCPDLEHIVQYHVAEAFRKDVGVAPGLIRIFFHDCFPQGCDASVLLTGNNSEQALGPNLTLRPVGLNLIETIRAAVHRSCGRTVSCADITVLATRDSVVLAGGPRFEVALGRRDGLAPASQDLVFTLPAPSFTVPELLKSFGDRNLDKADLVSLSGAHTFGIAHCPAFSDRFTPEVDTNPAIDPNFAAKLKAKCANDVPALSVNQSLDVRTPDVFDNKYYFDLIAKQGLFKSDQGLIVHPETTRMATRFALNQGAFFEQFAKSMVKMSNMDLLTGSQGEIRFNC... | 14 |
Q3UGM2 | 2.7.11.1 | ACT_SITE 655; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MPDQDTKAKSTEKTADKQQGTTTRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNNMTKSEPTIRTGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQHQLFQEIFTALVRNRLICREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHKLGGIEDLAQYMEIVANEYLGYAEEQHCVDKLVNMTYIFQKLAAVKDQREWVTASGAHKTLVSLLGARDTTVLLGALLALASLAESSECREKISELNVVENLLMILHEYDLLSKRLTAELLRLLCAEPQIKEQVKLYEGIPILLSLLHSDHLKLLWSVIWILVQVCE... | 99 |
A0DVP8 | 3.2.1.143 | ACT_SITE 221; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 239; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 240; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MIQMDVKEKKMYKFPTLSQRQMDLLTKLLSQQDRQNALPIINALTGNNGAQLRGLDTAISALDKNHRDMFFQYVLPKMAKYALDMLELSPKKELLISEGSIDFTRKEIYQFLSLSFFGLLVTQDEKFPDTYNLGHILQTDAEKSKCYLYYFIMASPDLENEIITVERIAFNADYHINQFFPNSQAKILEDAQLWSNCEKSLQTIEFVDQKIEEQQNSILVDFANKYVGGGVLSYGCVQEEILFTIMPENIIAVLFCKVLDFHQVVIVKNTIRYSDYEGYANSFRFVQRQPKNMNQNILVLDAINYKNNPDKQFQQNEIMR... | 159 |
U5CPU8 | 3.1.1.11 | ACT_SITE 240; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MENLMRILILILLLCFGLEQGQAKSLRKLQPPKILINFPENGTKNQLIEDQFMMWVEWVGSLKHSLFGAAINKIFPSFYLTVDKNPAKGDFTTIQSAIDSLPFINLVRVVIKVNPGTYTEKVIIPAMKAFITIEGAGADRTEVQWGDTAQTVGPTGQPIGTFNSATFAVNSPYFIAKNITFKNTTPVPKPGASGKQAVAFRISADTAAFLGCKFLGAQDTLYDHVGRHYYKDCYIEGSVDFIFGNGLSLYEGCHVHAIANNYGALTAQNRMSLLEDTGFSFVNCKVTGSGALYLGRAWGAFSRVVFAYTYMDNIIIPRGW... | 125 |
A0A078FJR9 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARFGLVFVTILVILGLVSFSEAQLKLGFYDKTCPNAEKIVQAVVNQHIRNVPSLAAGLIRMHFHDCFVRGCDGSILINATSSNQQVEKVAPPNLTVRGFDFIDLVKTVLERKCPGVVSCADIITLATRDSVAAIGGPTWNVPTGRRDGRISNATEALNNIPPPFGNFTTLITLFGNQGLDVKDLVLLSGAHTIGVSHCSSFSNRLFNFTGVGDQDPSLDSEYADNLKSRKCLSIADNTTQVEMDPGSRNTFDLSYFKLVLKRRGLFESDAALTKDPTALGQVRSFAGGSLQDFFVEFGKSMEKMGRIGVKTGSDGEIRR... | 14 |
A0A3Q7G7T0 | 1.11.1.7 | ACT_SITE 92; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MPINLTILVTIIVQINYLAIAMVSTTLSSFLLVLVLSFFVSEAQRPALTKGLSWSFYQSSCPQLESIIRNRLQKQIKDDVGQAAGLLRLHFHDCFVQGCDGSVLLDGSAGGPSEQTAIPNLTLRKRSFKIIDDLRKRIQDECGQVVSCSDIVAIAARDSVVLTGGPNYDVPLGRKDGVNFATEQATIDNLVAPSANTTTVLSLLATKGLDATDAVALSGAHTIGISHCPSFTDRLYPNQDSTMDKTFANNLKGSCPTADSNNTVNMDIRSPNVFDNKYYVDLMNRQGLFTSDQDLYTDRRTRGIVTSFAVNQSLFYEKFV... | 14 |
A0A3B3I6E7 | 2.7.10.1 | ACT_SITE 777; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MTFGSRWVFISLVVGMSLTRHSLCNQVSDGGAGQAATAKLRSDGGPVSEIRFLYTVVLLDTTSVLGELGWKTYPINGWDAITEMDEHNRPIHTFQVCSVMEPNQNNWLRSNWISRQAAQKVYVELRFTLRDCNSIPWVSGTCKETFNLFYHETDEAHGVKFNPAPYKKIDTIAADESFTQMDLGDRILKLNTEVREVGPIRKKGFYLAFQDIGACIALVSVRVYYKKCPFTLRNLASFPDTVPRMDSSSLVEVRGACIDHAEERDTPKLFCGADGDWLVPLGRCVCSVGYEEIDGSCVACRPGFYKAYAGNIKCSKCPPH... | 97 |
I1GRW0 | 1.11.1.7 | ACT_SITE 91; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGSEKQQIAGLAVVVAIALLGCACDASPLFHYPMVPRQSPAPGYSPLSEDYYKGKCYDHDVELIVKDVVYKALSEPYGRGIGAGLIRLFFHDCFVQGCDASVLLDPTPTNPEPEKHGIPNRNSLRGFEVIDAIKKAVNEKCGNIVSCADILAFAARDATVFLSKERVGYFKMPAGRYDGKVSLASETIPNLPPPFANLETLKAMFKTKGLETDEMVTLSGAHSIGISRCSSFSDRINASSPSDMEPGLANELRAKCNNQPSVTVDQDSVTPVDLDRQYYKNVLNKKVLFQSDAVLSSGETVGQVWLNANWPGLWESRFKA... | 14 |
H2XKZ9 | 4.1.1.17 | ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | ESDSSFYLGDLGQIVRNLQMWRKHMPQIRPYYAMKCNPSQPVIQLLASLGVGFDCASGFEIESALKCGVQPDDILFAVPCKMSSHIKYACQTGVRTMTFDNADELHKIKRIHPTGKLLLRLRVEYCGIGIKMDDKFGASMSEAEKLILLCKELKLNLAGICFHPGSGSNSFDPIDRSLQQCRELYDFANLNGIDLKIIDIGGGLVCTESFIKVSFQITTAVNKLFPPETGVKVIAEPGTFLVENAFSFVTNVHGKALVGVYVGINISKSLSTDTAKYYIGAGVFTAFNLKFFEEFKRIPENLSREAEKGKYYRTSVYGPT... | 195 |
F6PPP8 | 2.3.2.26 | ACT_SITE 838; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | RSLSEEEGSRLVRIQVLSGHNLAKKDIFGASDPYVSVSLYKPKRSASGSSKTITCVNTKTKKRTLNPSWNEKFLFRVVPRENRLLFEVFDENRLTRDDFLGQVDIPINASYISNDDETGTPHREFPLRPRSSKSRVKGHLRLKLSYADLPSTNDNNDDSPNEGDWELVDEETREGPVLPGGWEERQDHLGRTYYVHHETRRTQWQRPVVPETPSTSSDSDVTMGTAAAAELFRQRRHISEDVTEQPRSSRNEDHSWEVISETSSTDPPTPPPLPRSPSLPSEYDVIMWWCDVTISGQAEMTSSSVTTVDGELPDGWEARV... | 65 |
P43757 | 2.2.1.1 | ACT_SITE 413; /note="Proton donor"; /evidence="ECO:0000250" | MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTLIICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPE... | 51 |
B5YJA6 | 2.7.1.25 | ACT_SITE 109; /note="Phosphoserine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00065" | MKKSNNNLTLYKGYINREDRERLHGHKSFVIWFTGLPASGKSTIAHLVEKELYKRGCSTYVLDGDNVRYGLCSDLGFSIEERKENIRRVGELVKLFVDAGIIVITSFISPFKEDREKVRSLFKEEDFIEVYTKCPVETCSLRDQKGIYKKAIKGEIKNFTGISAPYEEPENPEITIFTDIDSPIEACQKILRYIKDKLKL | 90 |
A0A9R1VJ79 | 3.1.1.11 | ACT_SITE 272; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHTRTLHHIPKPNFTSLLFFIPISTCLHILMAKFGYIWSLFILLLVLDAITPTLCHTKGLQPKRNTWKQLGANLTQTQYSEQQFMKWVNFVGSLKHSLFSPAKNKLFPSYMITVDKNPARGDFTTIQQAIDSLPFVNLIRVVIKVHAGVYKEKVNIPPLKSFITIEGEGAEKTVVQWGDTAQTIGAKGQAVGTFGSATFAVNSPYFIAKNITFQNTTPVPKPGAVGKQAVAFRISADTAAFVGCRFLGAQDTLYDHLGRHYYKDCYIEGSVDFIFGNGLSLFEGCQVHAIAPVTGAVTAQGRSSLLEDTGFSFLRCKVTG... | 125 |
Q8EDH3 | 1.1.1.100 | ACT_SITE 155; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MSINLSLAGKVALVTGASRGIGRAIAETLVEAGAVVIGTATSEKGAAAIQEYLGDKGFGLVLNVTDSQSVTDLFDSIKEKAGDVDILVNNAGITRDNLLMRMKDDEWNDIIDTNLTSLFRLSKPVMRTMMKKRFGRIINIGSVVGTMGNAGQVNYSAAKAGLIGFTKSLAREVASRQITVNAIAPGFIQTDMTDELTEDQQKAIMSQVPMERLGQAQEIANAVLFLASDSAAYITGETLHVNGGMYMV | 2 |
A0A9R1WQS0 | 5.4.99.12 | ACT_SITE 84; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1" | MGYAALGVGLPLAAAHLDDLYNQQTPPANTYKWRLVLSYDGTRFSGWQYQPSTPTLQCLLEQALTRVTKLERKDLCVVGASRTDAGVHALGQVAQFVTPFNYKDLQDMHAALNGLLPPDVRIREISPALPDFHARFSVTGKIYHYKIYNDTVMDPFHRLYAYHNLSKLNVSVMKEAAKYFVGKHDFSSFANKQRNDRIVNPVKNISRVDIIEKGPILQVEVEGSGFLYRQVRNMVALLIQIGREALPPDIVPKILETCDRKELAKVALVAPPHGLFLVEVKYNEEHLGLPEDGPSTSFGRHHSISKCKLQYY | 217 |
Q0VFH3 | 2.3.1.181 | ACT_SITE 178; /note="Acyl-thioester intermediate"; /evidence="ECO:0000250" | MSVPVLRVRRLGLVGYAEALGVQGRYVRELKAGGEAGSPGGALLLCEHPAVYTVGVRRGRYPGEEEARLRGLGADFQRTDRGGLITFHGPGQLVCYPVLHLGALRRSLRSYVCGLESAVIRLCRGLGLPGERQPDTGVWVRGNKICAIGVHCARHITSHGLALNCNTDLGWFGHIVPCGIVGKGVTSLTQELGRQVTIDDIIAPFLEAFEEEFQCQLVPEQNPEQNPVQNRPDRDAGPL | 55 |
P17157 | 2.7.11.22 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS | 102 |
P53043 | 3.1.3.16 | ACT_SITE 311; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P53041" | MSTPTAADRAKALERKNEGNVFVKEKHFLKAIEKYTEAIDLDSTQSIYFSNRAFAHFKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDPAATKALLTCDRFIREERFRKAIGGAENEAKISLCQTLNLSSFDANADLANYEGPKLEFEQLYDDKNAFKGAKIKNMSQEFISKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIY... | 144 |
A0A1U8A127 | 3.1.1.11 | ACT_SITE 164; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSVRVLKVSQDGSGDYRTVQEAIDAVPLGNTCRTVIRVSPGVYKQPVYVPKTKNLITLAGLRPEGTVLTWNNTATKIDHHQGSRVIGTGTFGCGSTIVEGEDFIAENITFENSAPEGSGQAVAIRVTADRCAFYNCRFLGWQDTLYLHYGKQYLKDCYIEGSVDFIFGNSTALLEHCHIHCKSAGFITAQSRKSSQESTGYVFLRCVITGNGGTNYSYLGRPWGPFGRVVFAYTWMDACIRPVGWNNWNKPENERSACFYEYRCFGPGSCPSKRVTWCRELVDEEAEQFLMHYFIDPNPERPWLVQRMGLKMSENMIEFH... | 125 |
Q748C0 | 2.3.1.286 | ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MELRERFLRAAEALRRAEVLVITSGAGMGVDSGLPDFRGDSGFWKAYPPYERLGITFVGAANPAHFEKDPAFGWGFYGHRTNLYRATVPHAGFGIIRAWIERYGLDHFVVTSNVDGQFQKAGFAEDRILEVHGSIHHLQCTKPCTMAVWENRETIPVDESTMRAGHIPRCIHCGDVARPNILMFGDYGWISGRTARQQRNFDEFLTEVRGRRAVVVELGAGTAIPTIRYLTEEVGSLHQAVAIRINPREAQIGAPHISLACGALEGLAGIKSCLE | 58 |
P0C5E2 | 2.7.11.1 | ACT_SITE 465; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNPSTPSLLYTSIFFYFTIIATQTLSLDPKFKACEPKSCGKGPQISYPFYLSGKQESFCGYPSFELTCDDEEKLPVLGISGEEYVIKNISYLTQSFQVVNSKASHDPCPRPLNNLTLHRTPFFVNPSHINFTILYNCSDHLLEDFRTYPLTCARNTSLLRSFGVFDRKKLGKEKQIASMSCQKLVDVPVLASNESDVMGMTYVEILKRGFVLNWTANSCFRCITSGGRCGTDQQEFVCLCPDGPKLHDTCTNGKNDKRRRVIVKVLIGASAAVVGLIAASIFWYVYHRRKTKSYRNSSALLPRNISSDPSAKSFDIEKAE... | 99 |
A0A3B3HKM1 | 2.7.11.13 | ACT_SITE 506; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MTLSPCPYHHVFVHLWKQVILGPVTMAPFLRIAFNSYDLGILPPSADKPFCAIKIKEALTTDRGKTLIQKKPTMYPAWKACFDAHIYEGRVLELLLMRTADEALAEVSVGVSVLAERCKKANGRAEFWVDLQPSGKVMMAVQYFLEDVDAESKQAVKEEEAPTLNRRRGAIKQAKIHFIKNHEFIATFFRQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTVFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGLVKQGLKCEDCAMNVHHKCQKKVANLCGINQKLLAEALTQVSQK... | 100 |
A0CY06 | 2.7.11.1 | ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MDDDSHILIDDITSMSHEMQIDETIIKQYKKQRLLGVGAYGKAYLVTSDDENQIKYVMKVLPQSPSAKQEALILQNLRHENIIQYVETFVDSKNRLCIIMEYANNGTLGQYIKSRQQPLPETQIVDWFTQLCLAIQCVHSQRIIHRDIKAENVFLQDDKLKLGDFGIARSVEQTLATTFIGTPYYLSPEIIQNQPYSYKSDIWALGVLLYEMCTFKYPFQAESLPGLATKIIKGKIQPISAQVYSQNMKNLIQSLLQIDQNKRPSIEQILCIIQSLLRKSNNLKQDQIIKYQIVTNNKASSITDVKEIVTLGYYKKG | 99 |
O15726 | 2.7.11.1 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEIRVANKYALGKKLGSGSFGDIYVAKDIVTMEEFAVKLESTRSKHPQLLYESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVRMTADQMLNRIEYVHSKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKKYRDSRSHTSYPYKEGKNLTGTARYASINTHLGIEQSRRDDIEALGYVLMYFLRGSLPWQGLKAISKKDKYDKIMEKKISTSVEVLCRNASFEFVTYLNYCRSLRFEDRPDYTYLRRLLKDLFIREGFTYDFLFDWTCVYASEKDKKKMLENKNRFDQTADQEGRD... | 99 |
P17169 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000250"; ACT_SITE 604; /note="For Fru-6P isomerization activity" | MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFVSETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQYDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILACGTSYNSGMVSRYWFESLAG... | 81 |
I1IYF9 | 5.1.3.3 | ACT_SITE 191; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 332; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MARVPLLVALCLVCFASGASAAGRKMVGVYELRKGDFSVKVTNWGATVTSVVFPDSKGNLGDVVLGYDTIAEYVNGSSYFGALVGRVANRVAKARFVLDGKVYNLYANDGKNALHGGHRGFSKVIWTVKEYVAGGDSPHITLYYHSFDGEQGFPGDLDVYVTYELSSPYVLRVRMNATALDKATPVNLAQHTYWNLGGQGSGRDVLGHTVQLFAAHYTPVDGTLIPTGQLAPVAGTPYDLRTPTAVGARVRQVSGGSSNGSAVYGFDINYAVDGEDARALRKVAVVRDGASGRAMELWADQPGVQFYTGNFLKDVKGKGG... | 211 |
P00630 | 3.1.1.4 | ACT_SITE 67; /evidence="ECO:0000305|PubMed:2274788"; ACT_SITE 97; /evidence="ECO:0000305|PubMed:2274788" | MQVVLGSLFLLLLSTSHGWQIRDRIGDNELEERIIYPGTLWCGHGNKSSGPNELGRFKHTDACCRTHDMCPDVMSAGESKHGLTNTASHTRLSCDCDDKFYDCLKNSADTISSYFVGKMYFNLIDTKCYKLEHPVTGCGERTEGRCLHYTVDKSKPKVYQWFDLRKY | 130 |
A0A9J7LIX1 | 3.4.19.12 | ACT_SITE 84; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 261; /evidence="ECO:0000256|PIRSR:PIRSR013503-1" | MAEANSKPGESLDKALPSGVEYDEAIMAQQDRIQQEIAETSQLIGDHEDLLLLSKEYSEEDNVYQGKIKDLRSKYKCFRRTRGDGNCFYRAFGFSYLERLLDDRKDLERFKEVAAKSKDMLVSLGFPAFTVEDFHDTFMEVVEKVEQQIPVEDLLATFRDQGLSDYLVVYLRLLTSGYLQQNEDFFVNFIESYASVKEFCGHEVEPMARESDHIHIIALTSSLDVGVRVEYMDRAGSEEVNHHDFPEGTEPKVFLLYRPGHYDILYK | 175 |
Q83E13 | 5.6.2.2 | ACT_SITE 124; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MVMAEAAHEIIPITIEEELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMSELGNDWNKPNKKSARIVGDVIGKYHPHGDVAVYDTIVRMAQPFSLRYLLIDGQGNFGSVDGDAPAAMRYTEIRLSRFAHALMADLDKETVDFAPNYDETEMAPAVLPTRVPNLLINGASGIAVGMATNIPPHNLNEIINATLALIENPDLNVEELMRHIPGPDFPTAGIINGRNGIVQAYKTGRGRIYVRAKTEIETTKSGRSLIVVHELPYQVNKARLLEKIGELVREKRIEGISGLRDESDKRGMRMVIEVSRGDNAEIVLNN... | 222 |
A0A3Q7JYT5 | 3.1.1.11 | ACT_SITE 198; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNINITLFFVIFLVNYVIFLDFVHGLSVKNVIDSHVLTQKISTNRTIIVDINGQGDFKSIQAAINSVPNGNSNWVIIHVRKGTYREKVNVPPKKSYIFMRGNGKGRTSIVWSESSIDTTKSATFKVEAPNFVAFGISFKNQALDGATSTSPNQTSVAALVGADKVAFYHCTFLSTHNTLFDNKGRHYYEDCYIQGSLDFIFGSGQSLYQNCEIFVVADRRVDIRGSITAQSRFSDKENSGFVFVEGKVYGIGGVYLGRAIGAYSRVIFAKTYFSKTIVPQGWTNWSSPGSTKNLYHGEYKCHGPGSAIETRATWSKQLND... | 125 |
F6VYU2 | 2.7.10.1 | ACT_SITE 758; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | QMLNTLLMLCLLGKPLPSVQLDLYNSKSATTDLKWTPFSTGIGWEEVSSYDEGHRTTIRSYQVCPQEDTTVESDNWIRSPYIDARDGKLIHLDVEFSINHCSHDTLPDNMKKTQCKETFNMFYYEADGDVATSTFPPWREKPYVKIDTIAANSVNRVNTKTFSFGPITRRGFYVSVQDQGACMSLISLQIYYFYCGETWKNLAVFPKTVSGDSMASLVEVVGSCVDHAVQSTNLGSPEYRCNSNGRWQINTGGCVCDVGFQPNNQQTRCQPCPDGTYKVSNTISECLPCPNNSGFNISHTNHASNNECLCNTGYARASGE... | 97 |
A0A3B6DR77 | 3.2.1.14 | ACT_SITE 148; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MPILRMRASGVAAILAVVLAAALATAARAQQCGSQAGGATCPNCLCCSRFGYCGSTSHYCGAGCQSQCSGCGPTPPGPSPGGGVSSIISRDIFEQFLLHSSQCSDAGGFYTYDAFLAAAAAFPAFGTTGSTETRKQEVAAFFGQTSHETTGGWATAPDGPYSWGYCFKRELGSPPDYCQPSSEWPCAQGRQYYGRGPIMLSWNYNYGPAGRAIGEDLLNNPDLVATDATVSFKTALWFWMTPQANKPSSHAVITGQWTPTAADNAAGRVPGYGVITNIINRGLECGRGQDSRVADRIRFYQRYCNILGVGYGSNLDCYNQ... | 158 |
A0A9L0T8J6 | 2.7.10.1 | ACT_SITE 995; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MDSLAGLVLYGVSLLLSGEIPEVGMLSDKMKTYVKPKFEKQMKVELLGTVDGAMDLILINSLPLVSDAETSLTCIASGWSPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNRVCTACMNNAVCHEDTGECICPPGFMGRTCEKACGLHTFGRTCKERCSGPEGCKSYVFCLPDPYGCSCA... | 97 |
O04534 | 2.7.11.1 | ACT_SITE 469; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVLLLFLVLFFVPESVVCQRPNPNGVEFNTSGNMYTSGSAYINNNGLIRLTNSTPQTTGQVFYNDQLRFKNSVNGTVSSFSTTFVFSIEFHNGIYGGYGIAFVICPTRDLSPTFPTTYLGLFNRSNMGDPKNHIVAVELDTKVDQQFEDKDANHVGIDINTLVSDTVALAGYYMDNGTFRSLLLNSGQPMQIWIEYDSKQKQINVTLHPLYVPKPKIPLLSLEKDLSPYLLELMYVGFTSTTGDLTASHYILGWTFKMNGTTPDIDPSRLPKIPRYNQPWIQSPNGILTISLTVSGVIILIILSLSLWLFLKRKKLLEVL... | 99 |
P16912 | 2.7.11.1 | ACT_SITE 397; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDLWHIFLERILVACRVSASVFANFGCGLYSSWKLICGDHDSASGLRAGLATPTQRGKATGDNGTTGTPARTIGKPQARIATAMSTATCARFCTPLSSGTAGSTSKLTTGNGSGNTMTSAYKIPSNNSTTANDSSNTETTFTFKLGRSNGRSSSNVASSESSDPLESDYSEEDPEQEQQRPDPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGEGNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVRKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVK... | 99 |
Q89YX0 | 1.11.1.24 | ACT_SITE 44; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MKNIGDKAPEVLGINEKGEEIRLSAYKGKKIVLYFYPKDSTSGCTAQACSLRDNYSELRKAGYEVIGVSVDSEKSHQKFIDKNNLPFTLIADTDKKLVEEFGVWGEKKLYGRAYMGTFRTTFLINEEGIIERIITPKEVKTKEHASQILNQ | 12 |
O34431 | 7.2.2.10 | ACT_SITE 326; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000305|PubMed:12161109" | MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGKKTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAEQSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEIEESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMGKIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVSLAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCA... | 258 |
Q8S3F8 | 4.1.1.50 | ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAMAVSAIGFEGFEKRLEISFFQPGLFADPEGRGLRALTKSQLGEILTPAACTIVSSLKNDNVDSYVLSESSLFVYAYKIIIKTCGTTKLLLAIPPILKFAEMLSLNVKSVNYTRGSFIFPSAQPYPHRNFSEEVAILDGYFGKLGAGSNAYILGGQDKAQNWHVYSASADSVTQCDNVYTLEMCMTGLDREKAQVFYKEQSASAAMMTVNSGIRKILPDSEICDFDFEPCGYSMNSVEGAAVSTIHVTPEDGFSYASFETVGYDFKAVNLNEMVQRVLACFLPTEFSVAVHVDGASKSFEQTCFLDVKGYCREERSHEG... | 196 |
Q09792 | 2.7.11.1 | ACT_SITE 364; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAVITEENSNNLFCTDSLELTSNKQDDQVISNYLKPVRSYPYIKYSRSSLLLTASTTLPENFVISFTNSIESEESDKSDYLLDHAHSLQELSTTHSSLSSTLTSMSEESSSTESKFATLNDGINGGNPYSRLYRKNPSSDPNDIPPQFHFKKKSKSFYSSMYDKMKIRINILPNGNDNFIKKRNSGFALAPIACYNHTSDLRKLLKHKVTGSNASIFKRINPRSRKRVVNPECSVTDTPYGKLNNVIGEGASSFIRVINDRNKLPIYVAKVFRPPLDTSLLRRYVRYFIAEYTFASTLRHPNIIKVLDIIYKRHTILQII... | 99 |
W1PNQ2 | 3.4.21.92 | ACT_SITE 124; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 149; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MFRAALRSAIGAKSRLQTLDPTQMRSYGLIPMVIEQTSRGERAYDIFSRLLKERIVCITGPIADDTASLVMAQLLYLESENPSKPINMYINSPGGVVTAGLAIYDTMQYIHSPIRTICVGQAASMGSFLLAAGAPGERRALPNARIMVHQPSGGAQGQASDIAIHAEEILKTKDRLNALYAKHTGQDAEVIRQRLERDTFMSAEEACKFGIVDEVIQRRPVWLVSDAVGSAPSSSSLEGKANDKEGSK | 179 |
Q0V6E3 | 1.1.1.205 | ACT_SITE 357; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156"; ACT_SITE 468; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156" | MPISNGDAMTNTAVNALDYTTALEVLKNEYQERDGIDVKTLIDSKKNGGLTYNDFLMLPGYIGAAPNIHTIGFPAIDVNLDTPITKRITLKTPFVSSPMDTVTEHNMAIHIALLGGLGVIHHNCSQDDQAEMVRKVKRFENGFILDPVVISPTTTVAEAKALKERWGFGGFPVTEDGSLRSKLVGIITPRDIQFHDKLDDPVTAVMSTDLVTAPYGIDLKEANDILNKSKKGKLPIVDGDFNLIALLSRSDLMKNLNFPLASKLPHSKQLIAAAAIGTRPEDKIRLQKLVDAGLDIVILDSSQGNSMYQVDMIKYIKEKY... | 3 |
W1PLH3 | 3.1.1.11 | ACT_SITE 204; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MCHGESRNGLGVEEAYLKWVRNMGSLTHSIFSTAMKNKPKPSMYITVDKEPGSGDFVSVQEAIDSLPDGNGVRVVICIHEGVYREKVNIAATKAYISLEGAGAEKTVIEWDDTADKIGANGQPMGTFASATMAVNSPYFIAKNITFKNTAPVTKSAKGKQAVALRVSADTAAFFNCKFKGAQDTLYDHIGRHYFEGCYIEGSVDFIFGNGLSLYKGCHVHAIDRVGYGALTAQKRENMLQETGFSFVGCRVTGSGAFYLGRAWGTFSRVVFAYTFMDNIIARRGWYDWGDPSREM | 125 |
C0PCY1 | 3.4.19.12 | ACT_SITE 319; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 755; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MDLLRSHLHKVRIPEPTNRIHKDECCVSFDTPRSEGGLYVDMVSFLGFGREYVEWNFEKTGNPVYLHIVQRRKPEPDEADRPLKKPTLLAIGVEGGFGDQEPEYDETFEIVILPDFICLPFPSVDLPEKVRLAVDKVLLAESADRKEQLAAWVADKKNISAYAMDLQQLDNGVIVPPTGWKCSKCDKTENLWLNLTDGMILCGRKLWDGSGGNNHAIEHYEQTKYPLAVKLGTITADLEAADVFSYPEDDSVEDPLLAQHLSHFGIDFSSLQKTEMTTAERELDANTNYDWNRIQESGKDAELLFGPGYTGLANLGNSCY... | 175 |
B1H1H3 | 2.3.1.225 | ACT_SITE 120; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q9D270" | MKMRLHFVVDPMGWFCMSMVFFVWIYNSFLIPKLVLLPHYAEGHITAEPVICYYLASLLCFSALFRASTTDPGKLAQDPKIPLAERDNWELCNKCNMMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCFYTQVLSFYTLVLDFCQYYYFLPLSSVDQADFAVHHELALLRVSCFMGLIMFGGISSLFYTQVKGILTDTTTIEKMSHLTEEVPRRPWQQAMAEVFGTRWKVLWFLPFRSRHPLKLNLTIRSHV | 57 |
A0A8M2B201 | 2.7.10.2 | ACT_SITE 467; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000604-1" | MVDKVHLLPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHRPRGTEPKVGPFEDLKEQLIRQYVEQTWNLKGSALDQAIISQRPQLEKLIATTAHEKMPWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALCLLHNNQVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSERGATGGIISRLKSYSFPKPGQKKGSAENPYKITPNGKDDYSKQGNFLDSAMPMDT... | 98 |
B4F7T9 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARSCIMTATAPPPLVGAGVRLLAVVVAMLVVAGGGGGGGCCHGALLKAHFYRHSCPAAEAVVRDIVLARVAADPAKLPPKLLRLFFHDCFVRGCDASVLIDSTPGNTAEKDAAPNGSLGGFDVIDTVKAVLEAVCPGTVSCADIVALAARDAVSFQFGRDLWDVQLGRRDGVVSRASEALANLPSPSNNFSTLEAIFSSKGLDVKDLVILSGAHTIGVAHCNTFAARLSGSTTSAPGGGADPALNAAYAAQLRARCGPASTASSNNVTAVPMDPGSPARFDAHYYVNLKLGRGLFASDAALLADRRAAGMIHRLTRQGY... | 14 |
P15367 | 3.4.21.89 | ACT_SITE 44; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:10206957"; ACT_SITE 83; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:10206957"; ACT_SITE 109; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:10206957" | MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE | 178 |
Q0UPG4 | 2.3.1.48 | ACT_SITE 633; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MAEPGRLMGQTASNADPDDIDADGDYEMDDEYEQEQVAGAQISQLDGHSTDAEGSDVDAEGAVKIALRRPASSDEEDDYNDEEAVAHSSDAKTSDSEDESGAESEEEAPWQAESENGEEVEAARSDPNVCIYCNQDEENDPSPEYEEYLSCGVCGDNGYHLVPKLARDLLPSHRGVDPGGHSIFKEPHSSLTMPQTALTGFKGKRKASHEEEPVAQPSRGNRNKQRPSEASKSPVGGTSVNASSPALRPKSARSARSAITEAHDTEGEAQQTASDNDDEDDETRTRSRPRRSKMKRSNDKRPLAWIEEQQGLSLIMAFHL... | 61 |
Q0V0K3 | 3.4.19.12 | ACT_SITE 89; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 165; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSGGWNTIESDAGVFTYLIEKLGVKDVQFEELTTLEASELEQLGTVYGVIFLFKYPTGEARGETPKDGTYDHEAANNIFFAAQTIQNACGTQAIVSLLLNREKEVNIGKELKEFKEFAGEFPPELRGETLSNSDLIRETHNSFARSSPFIDETQRTATEDDDVYHFIAYTSINNTLYELDGLQPAPISHGACKPTEFPTKIIPVLQRRIARYPATEIRFNLMACVRDLRIRAREIGDEEELEQQEDRRAQWLWENSLRRHNFVGFISELLKGVVAAKLKEGNGAYDKWVEEAKGRSRKRREDARKQGIASED | 175 |
Q9W4C3 | 3.4.19.12 | ACT_SITE 315; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035"; ACT_SITE 984; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035" | MVKKRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTASCQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAV... | 175 |
B9I4T5 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKTAFIFACVAVLTVVGVCQAGDLRKDFYRTSCPAAESIVKNITETRAASNPNLPAKLLRMHFHDCFVRGCDASILINSANSTAEKDAIPNLSLANFDVIDEIKTELENKCAGKVSCADILALAARDAVSFQFKKPMWEVLTGRRDGNVSVASEVLTNIPSPFLNFSSLVQSFKSKGLTVHDLVVLSGAHTIGVGHCNLFSNRLYNFTGKADQDPSLNSTYAAFLKTKCQSLSDRTTTVEMDPGSSQNFDASYFVILKQQKGLFQSDAALLTDKTSSNIVGELVKSTDFFKEFSQSMKRMGAIGVLTGNSGEIRKTCGVI... | 14 |
A0A2G3A3M1 | 1.11.1.7 | ACT_SITE 114; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQNQDVDINDQKFEFSSRTDQKYKYCSLSYDDDDDCPYSFFDDHSFPPLPMFATTSVERRKLKQQQTASVVGSLRYDYYQQTCPQAERIIRSSVRDLFRKQPRIAPALMRLAFHDCFVEGCDASVLLDSADGIHSEKESPPNESLKGYDVIDIIKSELEEACPGVVSCADAVVLAARESIVLAGGPFYPLKTGRRDSMTSFAEDATFELPSPQDDLAKIIESFSAKGFDEREAVTLLGAHSTGVVHCKFFINRLYNFSGTKTSDPSINSKFLSFLKSKCNNSAASLMSSASKSRPPSQLISASPSPSSVVVQLSSTLVEE... | 14 |
A0A1Y1HLK0 | 2.3.2.26 | ACT_SITE 1264; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDDSANSDANITEDERSSGKRKLDEASGGEDFSNEEGFLTGRVTRMRVSETADKNGGASGGVNAGDLSELTTDSKATPNHQKHGTPSSALPPNGPANEDLGDGPLNPSLGGNPHASGPGHVGPPETPSPFEATPGSLLLPSSMEAAPASFSFPFLSEAPHASTAPSVYNGASLSESVLPPSDFVGDRPIHGQLNVFSSLPLQTAFVSDTNAHSDDQQLESGAFQGLSPVRVHEGSQDGAVLPSDTSGALVGLGLELSRGQTATTDGETPSDHEMVDAFAGSGNIPGGALEETAAQERASEPELQDLGPTASAVPSVVSAT... | 65 |
Q9FV53 | 3.5.1.88 | ACT_SITE 231 | MGLHRDEATAMETLFRVSLRLLPVSAAVTCRSIRFPVSRPGSSHLLNRKLYNLPTSSSSSLSTKAGWLLGLGEKKKKVDLPEIVASGDPVLHEKAREVDPGEIGSERIQKIIDDMIKVMRLAPGVGLAAPQIGVPLRIIVLEDTKEYISYAPKEEILAQERRHFDLMVMVNPVLKERSNKKALFFEGCLSVDGFRAAVERYLEVVVTGYDRQGKRIEVNASGWQARILQHECDHLDGNLYVDKMVPRTFRTVDNLDLPLAEGCPKLGPQ | 183 |
Q0UYS2 | 2.3.1.48 | ACT_SITE 203; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MAPDAGSLNGTTASPALKTPQKPSVTPNVLEVVFGSLLIKPWYPSFYPEQVVGRKLSWDIWAQKACPHRNTPPPGVNVYTKDNYSLYEIDGEKNKMYTQNLCLFAKLFLDTKSVFYDVTTFLYYMLVAHNPTPSIPNTGLGEDGVGQEGQVVGFFSKEKMSWDSNNLACILVFPPWQKQGLAQILMGASYEMSRREGRLGGPEKPLSDLGHLAYEHYWSATLARAILSCPSKKTITVLDLREKTYIVPDDIIATLQAMDVLEHRKKSGAEAVINKAKVRAWAESHRVNLKSLPVDPEAFVLRESSRSVSEE | 61 |
Q0E8H9 | 3.2.1.52 | ACT_SITE 372; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MKSTRTALGVALLLALVSQLAAHSSDDLVYGYECRSGYCQKVELSEENYVKAISLPVCRLFCGSSIGTLWPKPTGTVRLDTLMRQVDISFIDFNFNGIARQQKLWRAVEDRFMNMLEAQIPDRKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQHKNMTA... | 170 |
A0A1S4H7I1 | 3.1.3.16 | ACT_SITE 80; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 82; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MFRATLTKLQHINNVDRLKPPNRGFLETLFCCWRNGRTKSNQSGTPIDGSITPPPIQGQPRYLLPQVRPSDTYKKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKRPHVDEFLKKMGELYECVLFTASLAKYADPVADLLDQWNVFRARLFRESCVFHMGNYVKDLNKLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDINDSELLDLIPLFEKLSKVDSVYSVLCNSSSLSQLPTSMSHQNQQELQQSQQQQQQQQQQQQQLQSNSSDANNT | 144 |
D8QSM3 | 3.5.1.2 | ACT_SITE 78; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 196; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 198; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MAIGVLALQGSFHEHVLALRRLGVHAIEVRKADQLDGLAGLIIPGGESTTMAKLANQYNLFPALKDFSTSGKPMWGTCAGLIFLADRATGLKDGGQELLGGLDCTVHRNFFGSQVNSFETELAVPALAASEGGPPRCRAVFIRAPAIVEFGSSVEQIADCEVPSFSAPPSLEGEMFTRRRVAVAVRQGNFLGTAFHPELTSDTRWHSYFVKMVQAFEEVAASSALVPQKFCCRNDSFEEMKDLPIFEGLVQEKIL | 181 |
Q70EL4 | 3.4.19.12 | ACT_SITE 110; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 668; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVP... | 175 |
A7SUT9 | 2.3.1.286 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSVNYASGLSDYPNKGKCGLPEVFDSESELASKVSHLAEMIRAAKRVVVHTGAGVSTAAGIPDFRGPKGVWTLEEKGITPKIDVSFDSAAPTLTHMAIVKLQEEGLVHYVISQNVDGLHLKSGYPRSKLSELHGNMFVEKCDKCNKEYVRTTAVASVGQKRSGRACTQTRQRGSCRGKLCDTILDWEHNLPYNDLVNAEKNSREADLALCLGSSLQILPSGNLPVLTIKNGGKLVIVNLQRTKHDKKADLKINYYVDDVMKQLMENLELEIPQYTG | 58 |
O59702 | 3.5.1.98 | ACT_SITE 138; /evidence="ECO:0000250" | MGFGKKKVSYFYDEDVGNYHYGPQHPMKPHRVRMVHNLVVNYNLYEKLNVITPVRATRNDMTRCHTDEYIEFLWRVTPDTMEKFQPHQLKFNVGDDCPVFDGLYEFCSISAGGSIGAAQELNSGNAEIAINWAGGLHHAKKREASGFCYVNDIALAALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVMTCSFHKFGEYFPGTGHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVILQCGTDSLAGDRLGCFNLSMKGHSMCVDFVKSFNLPMICVGGGGYTVRNVARVWTYETGLLAGEE... | 184 |
A0A1U8BCL4 | 1.11.1.7 | ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MPPVRNESSSFHSEALTFISSLLPPFSALPLPKLLKLIYRLMVMSSSSSSSLLPPFSFYVCLLLLLLLLRISESETITKSKLTNTTRHYRQLSYDYHGKTCPQLEQLVASVTSQQYREAPISGPATIRLFFHDCFVEGCDASVLIASKPGNTSGLAEKDAHDNKNLPVEAFDSIKKAKALVENKCPGVVSCADILAIAARDFVHLAGGPYYQVGKGRWDGRISMASRVSFNLPRANSSVDELLKLFGSKGLNLEDLVALSGAHTIGFAHCEHFVSRLYDYRGTKKPDPYIEPRFLKALQMSCPPFGGNVDVVAPFDVTTP... | 14 |
A0A3B6I1B7 | 2.3.2.26 | ACT_SITE 1143; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MQKQPPSTSSPPAMSVPPSGHRQVSLRGSSAREITRDALLQKVSEERQLRSHLRRAAAAALTIQRVWRRYHLIRKVTEQLHEEWEVLVNQPDINLTNQWISSKMLRPFLFFITQPSSWYKGQQTKTVKSISRCFKIILNSINSMDQSKNFCSFVVGFPEERSIWLYQAKKLISLCSCILARCDHCCCKDVNMVEISTLTMRLAISLTDCKTWKNLTSENTRAADASVETLIEFIGTRQSGTYRCVRRYIKCFGPHITPGKIDSAIAPDEQLLVTASAVTLALRPFNSTRADMGVDLTGAAKEYFTLILTIPYICKRLPPL... | 65 |
P9WI55 | 3.6.1.1 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:26296329" | MQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGFIEDTLGDDGDPLDALVLLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGDPRWDHVQDIGDVPAFELDAIKHFFVHYKDLEPGKFVKAADWVDRAEAEAEVQRSVERFKAGTH | 188 |
A0A3B5Y4V1 | 3.1.1.11 | ACT_SITE 274; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAVSASSSGVRARARLLACVAVAALLLLAPGDVDAGRHGHGRGRGRGSGSVAHRHTKGLRPGKAMAARPYPANATAAEAIERRFTRWVWFMGGLDHSVFQRALNRALLPSTRTIVVDRTPGAGDFTTIQAAVDSLPLINLMRVVIKVNAGTYTEKVSISPLRGFVTVEGAGADRTVVQWGDTADTAGPWGRPFGTFASATFAVNSQFFVAKNITFKNTAPVPRPGALGKQGVALRISADNAAFVGCNFLGAQDTLYDHLGRHYYKDCYIEGSVDFIFGNALSLYEGCHVHAISPHYGALTAQNRRSMLDDTGFSFLNCRV... | 125 |
P19669 | 2.2.1.2 | ACT_SITE 84; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250" | MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRLREITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLGIKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQIIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK | 52 |
Q9VI13 | 2.7.11.1 | ACT_SITE 549; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q13153" | MSSEEDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTP... | 99 |
O88017 | 1.1.1.49 | ACT_SITE 346; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MSEELPAGAPQETKATKEAKETRTAQEAAGPLHAEEAEEARAAEAAKASGRAKAPRGAKKSATNRAAKEAKGKGAAGEGVEPVAPLDWSNPLRDPQDRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARRDWEDQDFAEVVHDAVREHARTPFREEVWQQLSEGMRFIPGDFDDDNAFEQLRKAVEELDASRGTSGNYAFYLSVPPKFFPKVVQQLKKHGLTDAPAGSWRRAVIEKPFGHDLDSARDLNALVHEVFDPEQVFRIDHYLGKETVQNILALRFANQMYEPIWNRSYVDHVQITM... | 6 |
A0A0K9NQ22 | 4.2.1.11 | ACT_SITE 252; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 386; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSVQDYLDKHMLSRRIEDAVNAAVKAKSSDPVLFISNHMRKAVPSVITKIKARQILDSRGIPTVEVDLYTNKGMFRAASPSDTAPGMYDTLELRDGGNEKYIGKGVSKAVKNINEKISEALVGMDPILQSQIDQAMIDLDKTENKSELDANAMLAVSIAVCKAGAAEKEIPLYEYIGDLAGKSNPVLPVPFITLISGGKHAGNYLAAQEIMILPIGANTFEEAMEMGSETYHHLKTVITEKYGSIGCNVGEDGGFAPDISSFTEALDMVKEAINRTGYGSRIQLALDVAATDFCIGNKYDLDFKSPDKSGQNFKTGEDMV... | 200 |
A0A251UZ14 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKNCASMTIAIISLLSILFFMSVSASNDRSLLTLPSLLDDATSFEEGLSNSLYHKSCHDVEGVIFRKVMEWVKKDPSLAPSLIRLHFHDCVLRGCDASILLNHSGSERSADVSKSLRGFQVIDDIKAELEKKCPRTVSCADILTTAARDATVLAGGPFWSIPFGRKDGRISLAKEATNVPMGRESVTKLIELFESKGLNVLDLVVLSGAHTIGRSTCESVQHRLYNYKGTKKPDPSINPVYLNYLRKKCRSTSGNVFLDATTPKAFDIHYFRNLKKKMGLLSTDQSLYSDLRTKPFVNALFNESSLFFNQFSVSMVKLGN... | 14 |
A0A2K1K7M6 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAHHAMRATVIAVVLVAMLAVTGVDATLRYGFYKHSCPNVESIIYKAMKAAYEKDNTVAPGVLRLIFHDCFVRGCDASVLLAGNNTERAALNNQGLHGFEAIDAVKDAVEKECPGVVSCADILAFASRDTVILTKGVGWEVPAGRMDGRISLSTEPLQELPPSTFTSQQLISIFAGKGLTAKQMVDLSGSHTLGITHCLHLRDRIFTTIDPTIPKNLLRQLQRKCPSNTSLTPLQIDRYTGNKFDTQYFRNIVRGRGLMTSDQDLFRDPATKPFVEANLKRATFDKNFAEAMVAMTSIEVKIGHEGEIRKHCQFVN | 14 |
A0A8I3NDE0 | 3.1.3.3 | ACT_SITE 60; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 62; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MCVSLPVLSFLLCRSASSAATASHFACVFINRDRRKILSRMVSHSELRKLFCSADAVCFDVDSTVIREEGIDELARFCGVEDAVSEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEHPPHLTPGIRELVSHLQERNVQVFLISGGFRSIVEHVASKLNIPSTNVFANRLKFYFNGEYAGFDEMQPTAESGGKGKVIKLLKEKFQFKKIVMIGDGATDMEACPPADVFIGFGGNVIRQQVKDNAEWYITDFVELLGELEE | 147 |
Q2G0J7 | 3.2.2.27 | ACT_SITE 59; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148" | MEWSQIFHDITTKHDFKAMHDFLEKEYSTAIVYPDRENIYQAFDLTPFENIKVVILGQDPYHGPNQAHGLAFSVQPNAKFPPSLRNMYKELADDIGCVRQTPHLQDWAREGVLLLNTVLTVRQGEANSHRDIGWETFTDEIIKAVSDYKEHVVFILWGKPAQQKIKLIDTSKHCIIKSVHPSPLSAYRGFFGSKPYSKANAYLESVGKSPINWCESEA | 173 |
D3ZU96 | 3.4.19.12 | ACT_SITE 119; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 370; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MTIVDKTEPSDPSTCQNQPGSSEAVSPEDMDTGSASWGAVSSISDVSNHTLSLGPVPGAVVYNNSSVPEKSKPSPPKDQVLGDGIAPPQKVLFPSEKICLKWQQSHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVTKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRFA... | 175 |
A0A139WIY2 | 2.7.10.1 | ACT_SITE 1130; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MAPSLSLFCAVLFIFLQLSLFVNCFHYIKPEILSEYETIISAGDNFTVLCQGETPLTWKLPDVKDENYSQWTVIDILNVLPKNSTFKYASRLFIHNATFPFTGFYKCHGTNIDPSDNDLVASIYLYVKDDEHLSATIEDIDTIFVTQYSDAVIPCRPTSPDVRVELYYIDGMKKPKVYLGIIDEEGIMYRFHPHFGFITNNTKEQDQKLYVCKFANGLHNFSVTIIMEVELFARIVTPYLFQVENSTYDPKTGFRFYVTSLAHEGLFICQFEQGTADFELNFYLKVLPLIHSVPKPLLEELSGGHTVVGQQLILECKVKI... | 97 |
Q7TSC3 | 2.7.11.1 | ACT_SITE 124; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDNFHLIKIIGEGTFGKVYLAKDKSESSHCVIKEISLTKEKEASKNEVILLARMEHPNIVTFFSSFQENGRLFIVMEYCDGGDLMQRIQRQRGVMFSEDQILCWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNGMVAKLGDFGTARTLNDSMELAQTCAGTPYYLSPEICQNRPYNNKTDIWSLGCVLYELCTLKHPFESNNFHHLVLKICQGRVAPISPHFSRDLQSLIPQLFRVSPQDRPSVTSLLKRPFLETLIARSLYPEVCSRRIQSHAHMENMAIGPTACWRVSPWSAAYLQRKFEAQQYKLKVERQLGLRP... | 99 |
A0A2K1J2N2 | 3.4.19.9 | ACT_SITE 149; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 265; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 265; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MAVSGGRTLIPITALIASVLCAVLLLQQVESAYQRPKEVQTERPVIGIVTIPEAGCLHFGDQVVVSSNARWLQAGGTRVVPIFYDSTPEELDYILNRVNGVFWSGGPVFFNPHTESHSGSLYLRTTEYILKHVMRENRRGNYFPLWGTCLGFERMVQLVAEDAEASIVKPVDAENYAINLGFTDVAFESRLFRSMNAELFKEVASPATRLAFNNHGLGIHPDYFHNITNLSRHFSVLSVDLDRHGKPFVSTVEGKRYPLYGSQWHPEKPPWEWSPDWVLSHTNMAIQLSNYFGRFFVEECRYNKNKFESPELEDKLLLHN... | 176 |
A9UYA3 | 3.5.1.2 | ACT_SITE 84; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 188; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 190; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 237; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"... | MVHTSQVYLLDYGAGNVRSVINAVETQGFQLKYIQSVEDFDKADKIIFPGVGAFASCMAKLEALGYVEPLRKYIASGRPFFGVCLGMQTLFEASEEGEGLIKGLGVVPSVISKFEVPGLAVPHMGWNVATVCKPNPILPHDQERYYFVHSFKAMPTETMRDWVMTTTTYGVEFVSSIFLNNVMATQFHPEKSGTAGLHIFRRFLELPDLITAPAYPLADPAVGSKAGLAPRVIACLDVRANDAGDLVVTKGDQYDVREKDDAGDVRNLGKPVELAKRYYEEGADEVTFLNITSFRNSPLKDQPMLEVLRQTSREVFVPLT... | 181 |
W1PR61 | 3.4.19.12 | ACT_SITE 16; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 128; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 143; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MENKEIYHEKQRLQFCLLHALNNLLQGKDSFTRSDLDDIANKLDLIDPNKEGQSPLSLIWKSHHNSLTGNYDINVLISALEGRGKRVVWHDLRKGASSIDLSLSNISLIGVLLNVPVRKLGGLWRSRHWVALRMINGIWYNLDSDLKAPKPFENVDEVVTFLDAILSQVFKLPEASENGDPLSLGILNLHKRFQDYHFGVIGEIMLSMLNEDLPFTLFLPSEAAFERLLKINVNGTSVYNKENNTDVILSRVLGFSVIPIKLRSEDVPLTREISFDSLAGFELNIMRLPEKVLSVDNVRSERVDMRRGEIIVHVMDGVIM... | 175 |
A0A9R0J8W0 | 2.3.1.181 | ACT_SITE 178; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MAVRRCLEVWKMGTVNYMNALKLQENLVSDRKAQKITNTLLSLQHPPTYTLGKRKTDHNLLVPEPELINMGAELHYTQRGGDITFHGPHQAILYPIISLRDIGVGARSYVEKLEQTMIELASMYGVEARPGQKGETGVWVGDRKIGAIGVRIQSGITSHGLAFNIDPDMNYFKHIVPCGISDKEVTSLRRETNLELLTEEVIQEQLIHCFARQFDFSSVLLDKSNIY | 55 |
K3YUW5 | 3.2.1.14 | ACT_SITE 134; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MAANKLAAAAALLLVVLAVAAATPASAQKCGCATGLCCSRFGFCGTGNDYCGTGCQSGPCNMPATNNVSVASIVTPAFFDALLAQAAAGCEAKGFYTRDAFLAAAGYYPSFGRTGTADDSRREIAAFFGNANHETIRFCYVNEIDGPSKNYCDAGNTEWPCQAGKGYYGRGPLQISWNYNYGPAGQSIGFDGLGDPDAVARSAVVAFRAALWYWMNNVHEPLLASGGGFGATIRAINGALECGGKNPTAVNSRVGYYKQFCQDFGVDPGSNLTC | 158 |
A9UNQ5 | 2.3.2.26 | ACT_SITE 566; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MASPDLAFYCLCLALEVISCKAQRSAGRLLLSDSIATDIGVYWNMVQAQLSPHVFKARMAAWVAAQSAPALEALTFAIRVTVNRQTTHTLAAEVDALLQLGQHIRNQVPAANLVCEAFARRINIKEAFYEYIAIIKRDQHTYLIPFRTDFLQHMFHSSAAKAKTSYLAYPFIFPASIKRQLLRFQAAFEMSREFQRAFYNHALSLELDRVYRCAERQRPAQTPQEKALSSPYLVLTVRRGHETQDVFNCLARHPQMYRRPLKVRYISSGEQGLDLGGLQKELLKQVWEDVSNPEHGLFIMHDDSRFLWFQTSLPTVPARH... | 65 |
Q381V7 | 5.3.1.8 | ACT_SITE 278; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MSKLIKLDCGVQHYAWGKEAAESYVAKMKGEGNKEGKYAELWVGTHPNCPSKTFSGQNLDDFLKNDNNMSRFVHPKQQADPRFRDTVPFLLKLLSVQTALSIQAHPNKQLAEKLHRENPEKYKDPNHKPELVVALTPFEALCCFRPLKDILEFLESASPLKTLLGPAADVLPGEVEDSEAIKHMMDIVYNTDAKKHAEALQEHAEELRSRGGEMTKEDSVFLRVLYQYPDDMGCWMVYFLNYVQLAPGEGLFLADSEPHAYLFGDSVEIMACSDNVVRAGLTPKWKDVPTLLRMLRYGTDGLERAKFERYRAPEGSEWEL... | 214 |
E9H1P2 | 2.3.1.286 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSCNYADGLSPYEDKGKLGIPEKFDSLDEVAGKILILAKWIKEAKHVVMHTGAGISTPAGIPDFRGPKGVWTLEKKGLKPQINVSFDDAEPTFTHMAIISLFQTNYLHYVVSQNIDGLHLKSGLDRTKLSELHGNMFIGQCSLCSRQYIRRKAVTSVGQRELPVDCPALKGGKLSCRGKLHDTILDWEHELPTRDLGLADIHSNVADLSICLGTTLQIVPSGTLPLATKRKGGRLVIINLQPTKWDKKADLVINTYVDDVMKLLLKELNTPSLPYDPKCDPTRQPLSEKEMWQEEFTKREWTLGARAVSTTRKRLSHPEN... | 58 |
Q5KAN4 | 2.7.1.11 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSDSPAATPLPKDPEGITEQIQSVSTPPPPPQAQKPARQKKIAVLTSGGDSAGMNAAVRAIVRQSIARGCQAYIIREGWEGLVRGNTSGPTPAPTAPQSPTLSASSKTVTFSSLPPSQQFDKLTSTLNKESLANEVSFSDPNEVTPLEDTPLSFGYGQLLRDGAGEGDVEELASHGMQGLAIADREDEKGRSLKNKYIVRVGWDDVRGWQGEGGTLIGSSRCPAFRTREGRLQAASNLIHSGIDCLAVCGGDGSLTGADKLRGEWPSLVEELYTENKITDDQREAYHHLNIVGLVGSIDNDMALTDLTIGALTALHRICE... | 84 |
Q9SY91 | 2.7.11.1 | ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MRDSSTTASTKSSPLWKPFASNCCSVDDQTVFGNLSRCRPSRSEFSKNHLGPLPSFRRLSFADLSRSSSARINEDLAQTLGADLVDFQMCELKMITQSFSGNYLLGEGGFGKVYKGYVDDYLRQSLKAQPVAVKLLDIEGLQGHREWLSEVIFLGQLKHPNLVKLIGYCCEEEERVLIYEFMPRGSLENHLFRRISLSLPWATRLKIAVAAAKGLAFLHDLESPIIYRDFKTSNILLDSDFTAKLSDFGLAKMGPEGSKSHVTTRVMGTYGYAAPEYVSTGHLTTKSDVYSYGVVLLELLTGRRATEKSRPKNQQNIIDW... | 99 |
P34649 | 2.7.11.1 | ACT_SITE 388; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MANCENNPWKKNAWGKNEETAEEPIVSFADVLSEEFIEDLSVQEKLEEERYMKQLDQMFGDTSVSDDQLPINTEGMTDEEVALALQRHFDREADVARAVGSSSSVHFTPDRYHPKTMQETDSENEDDDALRQAATDMLYAKLDEENATNSRLRPEGPSTSRTKHDTGVSGRRNADKTFNDRNTLPTGDMVGDKLNNKVFNKLMAFGKSESKRQMRNKDKEEKATMDTSVDSDTRLLLLKWINQGVFDSVDGIIATGKESAVLHAAQDSATSYAIKVYKTTLSEFKNRSEYVKDDFRFKNPRGVLKIWAEREFMNLSRMAK... | 99 |
P40553 | 1.11.1.24 | ACT_SITE 107; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000269|PubMed:12730197" | MGEALRRSTRIAISKRMLEEEESKLAPISTPEVPKKKIKTGPKHNANQAVVQEANRSSDVNELEIGDPIPDLSLLNEDNDSISLKKITENNRVVVFFVYPRASTPGCTRQACGFRDNYQELKKYAAVFGLSADSVTSQKKFQSKQNLPYHLLSDPKREFIGLLGAKKTPLSGSIRSHFIFVDGKLKFKRVKISPEVSVNDAKKEVLEVAEKFKEE | 12 |
O24598 | 3.2.1.14 | ACT_SITE 129; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MALTKIFLILLLSLLGLYSETVKSQNCDCAPNLCCSQFGYCGTTADYCGSTCQSGPCRVGGPPTGAGLVGNIVTQIFFNNIINQAGNGCAGKSFYTRDSFINATNTFPSFANTVTRREIATMFAHFTYETGHFCYIEEINGASRVMCDQNNRQYPCAPAKSYHGRGPLLLSWNFNYGACGQSLGLDLLRQPELVSSNPVVAFRTALWFWMKSVRPVLNQGFGATIRAISGFDCDGRNLGGVNARIGYYRDYCGQLGLDPGANITC | 158 |
Q8Y5T0 | 2.7.7.7 | ACT_SITE 107; /evidence="ECO:0000255|HAMAP-Rule:MF_01113" | MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAMPTRQAAKLCPNGIFIHGNMAHYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMKSATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKKPAGITVVTPEEAEAFLEQIPVTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPHRDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTITKRLTLNEYTNDASQIYQAAA... | 121 |
G1KHN2 | 2.7.11.1 | ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000605-50" | MAGVFDLDLETEEGSDGEEPELGGLDVDPDLRCSGPDQVPGYYEEIEISENIVNNGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNAGKIFAMKVLRKAKIACNAKDTAHTKAERNILEAIKHPFIVDLMYAFQTGGKLYLILECLSGGELFMQLEREGIFLEDTACFYLGEITLALGHLHSNGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHDGAVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTIDKILKGKLVFPPYLTPDARDLIKKFLKRNPSQRIGGGPGDAADV... | 99 |
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