Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A5F8G5U2 | 3.1.3.48 | ACT_SITE 971; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1" | MHTAFPYWNRSKRKGEGSQAFHLCLSRPSFPTLFPRLFPNPYLLERGWSRWRGPHTPSSRPSPPLGGCENWEKWSGIACDAYSVTRGGTEHAQEPGQVRAVSRKPLAFLGHPPHLGRLLLPDGPGYSTIVMNSRLRALGGRINNIRVSELPKEKTRSEIVCNLHFLDGLVQTFKVNKQDTGQVLLDMAFNHLGITEKEYFGLQHGEDAMDSPRWLESSKPIRKQLKGPFPCTLNFRVRFFIPDPNTLQQEQTRHLYFLQLKMDILEGRLICPLNSAVVLASYAVQSHFGDHNSSLHLSGYLSDSQFIPDQNNDFVTKVET... | 149 |
A0A078GAT7 | 3.1.1.11 | ACT_SITE 94; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAKTVISSNLSRLEFPKSTTASTATFSVFADNFIARDIKFVNTAGPEKFQAVAFHSKSNHSAMFRCAFFGYQDTLYAHVGEQLYRECEIVGTVDFIFGNAAAVFDMCSIRARKPLMQQVVTVTAQGADNQEKSGFSIIRSKILRFEDEEFTAVAYLGRPWKSHATVVIMETELGSLIDPKGWVAWNSSADPPPPTVNLGEFRNYGPGSDVRNRVTWVGYNPVMAEEDAQRFTIDGFINKLGWLNVSCVPYNGSL | 125 |
M5WV00 | 3.1.3.3 | ACT_SITE 92; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 94; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MEGLVGVSRVTPVRTHLRQKHLPFVPTSSLKFTKSLYKNRTRVGMNQHPKSPNPIAASIQPLEASVLSRFDNTQPSKEVLDLWRNADAVCFDVDSTVCLDEGIDELAEYCGAGKAVAEWTARAMSGSVPFEEALAARLSLFNPSLSQVQDFLEERPARLSPGIDELVKKLKANNTDVYLVSGGFRQMIKPVASILGIAPENVFANQLLFGTSGEFLGFDKNEPTSRSGGKATAVQQIRKAHNYKELIMIGDGATDLEARQPGGADLFICYAGVQLREAVAAKANWLVFNFEDLISSLD | 147 |
Q8ZA75 | 2.4.1.18 | ACT_SITE 405; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 458; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685" | MSVLPDRQVINQLISGHYGDPFSILGMHETSQGLQICALLPDAREVWLVETENGRRIAQLTLEDPRGFFIAQLTRRKKSFRYQFAVTWQENPQIIEDPYRFGPLLQDIDSWLLAEGTHLRPYERLGAHLMSLDGVSGVSFAVWAPNAQRVSVVGDFNFWDGRRHPMRLRRENGIWELFLPGIEAGQLYKFEIIDCHGQVRLKADPYAFEAQMRPETASLISPLPDVVKSSAARQKANDLCSPVSIYEVHLGSWRRHTDNNFWLSYRELADQLVEYVKYMGFTHVELLPINEHPFDGSWGYQPLGLYAPTRRYGTPEDFKA... | 73 |
A0A2G2YAA4 | 2.3.2.26 | ACT_SITE 443; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MCLVRKLLPLKEDGTYEAVCDEESIECLHLILYDLLDKMEPCLRKLEDQLALQEKGKGKPTSWWSRYLVVLKELNSISKLFNNSEVFWEKMRERKVSLRYLIVTFAKSPNDYLWVIEHKEVTNFKVRRHFAMVMLQKVRDKNEHEMLIDRSQLLEESFEYIGDADPTLLQGVLYMEFKHEEATGPGVLREWFYLVCREIFNALNALFVACPNDRRRLLPNPASKVDPMHLEYFYFSEEISLEDIRDADPILYNSCKQILDMDPEMVDQDTLSLTFVCDDVEELGSNNVVELCPNGKDTVVTSKNRKEYVNLLIQYRLVTS... | 65 |
P27121 | 4.1.1.17 | ACT_SITE 422; /note="Proton donor; shared with dimeric partner"; /evidence="ECO:0000250|UniProtKB:P11926" | MVMPTVVSDRMGTIDFIDYTNNHVFSKCQTDSLNTVNNGSLKHDDYLHGLANGKLVAKQMIGDALRQRVESIDSEFCEPGDEDTFFVADLGEVYRQHLRWKLNLPRVKPFYAVKCHPDERLLQLLAALGTGFDCASKAEIEQVLRMGVDPSRIIYAQPCKTNSYLRYVAQQGVRQMTFDNADELRKIARLYPDAELFLRILTDDSSSLCRFSMKFGASLDSTDGLLGLARQLGLNVVGVSFHVGSGASDPTAFLKAVQDAHVVFQQAAAYGYSLKTLDVGGGFCSDDSFEQMANVLRAALDEYFPAHTGVNLIAEPGRYY... | 195 |
F1MZX0 | 2.7.11.13 | ACT_SITE 478; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MAPFLRISFNSYELGSLKAADEASQPFCAVKMKEALSTDRGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPMSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRGEDEAKFPTMNRRGAIKQAKIHYIRHHEFIATFFGQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCQMKVANLCGINQKLLAEALNQVSQRSVKKETETQDTVGIYQNFEKKPG... | 100 |
Q7SZF7 | 2.7.10.1 | ACT_SITE 836; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MAGPTEIGLFFTLLLSGSFCATPEKKVCQGANNKLTLLGTVEDHYQVLLRMYRNCTVVLENLEITHITEKYDLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRGHSLYEDKFALAVLVNFNNSIEQGVKELPLTSLTEILKGGVKFCRNDYLCNVGTIEWADILNMKSLPTIVSHNISYGKNCGKCDPSCFNGSCWGTGPDKCQRMTKVICAEQCSGRCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPGTYEVDEGG... | 97 |
Q8Y5S7 | 1.1.1.49 | ACT_SITE 243; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MTDELEQKALITIFGGTGDLANRKLYPSLYHLYSKGSLGDNFAVIGTARREWSNDFFRDKVKESIKDIDGSEKDADAFASHFYYQSHDVTNKESYLTLKDLSDELDAKYELDGNRLFYLAMAPNFFGTIASRIKSEGFVDTDGFHRLIIEKPFGHDLASAEELNNSLRQAFKEDEIYRIDHYLGKEMIQNISVIRFANSIIESLWNNRYIDNIQVTLTEVLGVEDRGRYYDESGALRDMVQNHILQIVSLLAMEPPINLSTREIRHEKVRALRSLRVFEGKEVHQSFIRGQYGPGEVDGKELKGYRQEDNVDPHSNTETF... | 6 |
Q22236 | 5.6.2.2 | ACT_SITE 119; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01385" | MYEYSFNPNIDHEPGSVESQQSTIYSDSDDSDDSFLDDEVIPPKEQAMRKIEFALADIKRQMDNKEKSLTLRISTSKSHFCLRYTAKRKGKLDRDLHCLHQVYDLLENDKRSTKRELYYEHKAVYGNQKYLDSSIKSICELLNESRANLNILSCGRGIIRGAITFLVENVGVIDARVQEVLITDALLFSNIISEADFILVVEKDTTFQKLMDENFQAMFPRGILATSKGYPDIATRNVLKMLSEKRKFPIYGLFDADPHGIEIYLTYKYGPTKEFAEGRGAFVPTIEWIGLFPTDFHRFTIDQSQCLPLVRTDFVKIEKM... | 222 |
A0A022RRT5 | 2.3.2.26 | ACT_SITE 1484; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MENRGQKRTEDVDELPADKRPCSSLEFRPSSSNSSPQTPMSTAHESQDGDMDTSSSTSGSLRSEGGEGEKESVYGSCDSDNGVHDYYRHRIGNDQSKFKKMLSSLSEEVDESGQLALLTELCELLSFCSDSSLSSLMVDSFSPILVRLSRHESNPDIMLLAIRALTYLCDVNSRSSGFLVRHDAVPVLCQRLMTMEFLDVAEQCLQALEKISREQPLACLQSGAIMAVLRYIDFFSTSVQRVALSTVFNICKKLSPESPALFMDAVPILCNLLQYEDRQLVESVASCLIKIGDQVRRSPDLLDEMCKPGLVQHTLHHIGL... | 65 |
C5WYL1 | 5.1.3.3 | ACT_SITE 201; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAGGGAKRVLLLCLCVAVVLVAVGSGGAEARKRGKQSLGFYELRRGEFSMIVTNWGATILAVRLPDKNGHIDDVVLGYKDIGSYVNDTTYFGALVGRVANRIAGGRFTIKDRPYHTYQNDGNNTLHGGHRGFNQVFWSVRERVTGEFPHITFAYRSYDGEQGFPGNLDVLVTYKIDGDYSYSVTMYARPVDKPTPINLAQHTYWNLRGHGHGDVLRHAVQIFASAVTPVGGDLIPTGAVTPVAGTPFDFRAPAAPGARIAQVEGGVGYDINYVLDGETDGQGVRKVAVVSEDESGRVMELWGNQPGLQFYTGNFLDGDQG... | 211 |
C3ZAU5 | 3.1.3.48 | ACT_SITE 219; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000926-1" | MEAEFREIDKSGAWGQVYQGIRQEAAEHNHTLKCARKPENKFRNRYRDVSPYDHSRVQLQDGDNDYINASLVEATEANRQYILAQGPLPSTIGHFWEMVWEQRTKAVVMLNRVIEKGTIKCAQYWPQGEVNGYSDELDLEETGYKVTLLEEDVRPYFTIRTYLLHRLKTNESRKVFHFHYTRWPDFGVPESPAAFLHFLQEVRNSGSLESDVGPPVVHCSAGIGRSGVFCLVDTCLVLLDKTRDLNSLNMRQLLLEMRQYRMGLIQTPDQLRFSYLAVLEGARTVLGMATEEDQVISTLGESPDLQDGHNHIVTKDEEEN... | 149 |
P20483 | 3.1.3.48 | ACT_SITE 379; /evidence="ECO:0000250" | MLWETIVEENNCSMDCNISNNTSSSSSINKMSGSRRARRSLELMSMDQEELSFYDDDVVPQDQQRSASPELMGLLSPEGSPQRFQIVRQPKILPAMGVSSDHTPARSFRIFNSLSSTCSMESSMDDEYMELFEMESQSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSVRRCLSMTESNTNSTTTPPPKTPETARDCFKRPEPPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSLNDAEIMSALARSENRNEPELIGDFSKAYALPLMEGRHRDLKSISSETVARLLKGEFSDKVASY... | 149 |
A0A9J7LEX6 | 3.1.3.1 | ACT_SITE 127; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MGLYRFLLVATTILPTTMEQALSGRQTTFSEAQGRTPHQELDPAFWNDMAHRDLDRAIQLQKLNLNMAKNVVLFVGDGMGLTTVTTGRILKGQLQGQPGEETVLAMDSLPHVGLVKTYSLDYQVPDSAGTATAFLSGVKAARGTIGVNGRVQHGVCATQKGNEVNSILVLANQAGKSTGVVSTSSLTDATVASTYAHSASRYWDTDANLPWEAIYKGCKDIAAQLVDNAPDIEVLLAGGRQNFLPRSVADMEYPNKFGTRRDGRNLVEEWITTKPGTARFVWNLDEFNAIDSNRTDYLLGLFEPHHMKFSVDRDLDGAGK... | 141 |
Q1K9C4 | 2.3.2.26 | ACT_SITE 997; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00104" | MPLSFEGTFKAKRNVNLGGKRVSNDRAQLLRKAAMERKNREEERKAENNSVAVQSLSRGFLARRKFKQDFRERWIYKYTKSGRTSIRFNTLEDIKCSISLLVLFAEPDIDLPFVSQVAHNILVWLENLIPLSNGMDDTPKSHLKVKILKVQETLSNSNDSWLWQRFSSLLLNCLVSSINSHRIEGTDTSAETSLLHCLAYVAPYLKSSELSTYYDSVMTFYAQIYPKQNMTNLEDIMSLSLLTPVSSKTDENANSSSAFLFHVLASDCFSSIENCIPPDLIIDKVFSSSLQLSEEACISSLLNLGMIKVFSLAGNCLHLL... | 65 |
A0A7M7NYV9 | 3.5.4.5 | ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MDHLPEVIQELITKSNEAKNNAFCPYSNFRVGAALLTDDGTIIQGCNVENASYTLGICAERCAIFKAVSEGYRHFKAMAISTDVEKLYSTPCGACRQIMYEFGSDMDVYMTRPDLTYIKKTPRDILCYPFGPEELRMLKSGEVPKVDGDLNDNKMVDGTGDAKAHKKHKGDTAIPAQ | 187 |
A0A0A0LY08 | 3.1.1.11 | ACT_SITE 410; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSFLRPYGKVDETDQLRLDARRRTRRRIVVIVLSSVVLVAVVVAVVFGTRNASNNNDDSNNQNGSLSTSIKAVCDVTLYPDTCQKAFGPIANSSHLDPGQISKLSVQLALGELSKVADYIFDHAITKTADNKTILALKNCHELLDLALDHLNISLSSSDITLLKAVDDLKTWITSAATYQQTCIDDLAEVDPALADLVANFLKNSTELTSNGLAIVSFFSKLTDSLSLRRLMSYENHQSNGDWARPILRKLAQSDIRKHADIVVAKDRSGKYKTITEALGAVPDKSKKRTVIYVKKGIYKENVEVVKNKWNVVMVGDGMT... | 125 |
P55336 | 1.1.1.100 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10001" | MNLEGKIALVTGASRGIGRAIAELLVERGATVIGTATSEGGAAAISEYLGENGKGLALNVTDVESIEATLKTINDECGAIDILVNNAGITRDNLLMRMKDDEWNDIINTNLTPIYRMSKAVLRGMMKKRAGRIINVGSVVGTMGNAGQTNYAAAKAGVIGFTKSMAREVASRGVTVNTVAPGFIETDMTKALNDDQRAATLSNVPAGRLGDPREIASAVVFLASPEAAYITGETLHVNGGMYMV | 2 |
F6ZRV6 | 3.1.1.4 | ACT_SITE 66; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 110; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKPPPIMLFLCLLAVPLADGNLLQFGLMIERLTGKSALDYNDYGCYCGIGGSKWPVDEIDWCCHAHDCCYGRMNKLGCDPKLEKYNFSMTETSITCGGRTACQRLTCECDKNATLCFRDNLRTYNPKYAHYPNKLCTGPTPPC | 130 |
O35521 | 3.4.25.1 | ACT_SITE 21; /note="Nucleophile"; /evidence="ECO:0000250" | MLRAGAPTAGSFRTEEVHTGTTIMAVEFDGGVVVGSDSRVSAGAAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYGE | 180 |
Q7CQ08 | 3.5.4.33 | ACT_SITE 59; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00972" | MSDVELDHEYWMRHALTLAKRAWDEREVPVGAVLVHNHRVIGEGWNRPIGRHDPTAHAEIMALRQGGLVLQNYRLLDTTLYVTLEPCVMCAGAMVHSRIGRVVFGARDAKTGAAGSLIDVLHHPGMNHRVEIIEGVLRDECATLLSDFFRMRRQEIKALKKADRAEGAGPAV | 186 |
A0A6I8NZN8 | 3.2.1.35 | ACT_SITE 129; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MAGRPGLALWAWVVLCVANGRETSGTPHRPFMVVWNVPSAQCQTRFGTPLPLASFGILSNRAQRFRGQNVSIFYKNQFGLYPYLAPSGSQQNGGIPQAAPLNRHLARAARQICQLLRGDFEGLAVVDWEEWRPLWSRNWGPKRIYREASLAWLQQKCPWLSPSQRLRVAQASFEQAARAFMEDTLRLGRALRPRGLWGFYSFPRCFNPWQAGRNYTGHCHPTDRPRNDRLRWLWEASSALYPSIYLPPGLPAAQRQRYVGHRLGEAFRVAQFGRPSPLPVLAYARLSHHSSGRFLSQDDLVQTIGVSVALGAAGVVVWGD... | 166 |
A0A059AKW8 | 2.1.1.37 | ACT_SITE 1210; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MARKQGKEKAAVGNPKKASTANKKDRKRSSPQDGEEAAGSRKMPKRAAACTDFKEKSVLIDDKSSLIETKKAKLADEEILAIGLTAGREEGRPNRRLTEFILYNEEGVSQPLEMLEVDDLFISGLILPLEVSTEKEKDKENAVRCEGFGRIESWSISGYEEGSPVIWLSTDIADYDCLKPAASYKKYYDHFLEKARACMEVYKKLSKSSGGDPDCGLDELLAGVIRAMSGSKSFSNGSSIKDFLISQGDFIYNQLIGLDETSKSDRMFIELPALAALRDECNKHGNFAQAKSASSGKGIVIGSKSIDGEAAAQYGSSAGG... | 47 |
Q9LVP1 | 5.6.2.1 | ACT_SITE 342; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383" | MSRRGGGPVTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYF... | 221 |
A0A2X0SPB7 | 1.11.1.7 | ACT_SITE 95; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQPRSTRIFIHPFPLPCSIRPRAPKFIESSAMASATFFILVAAASLLASFAQADLQYGYYNMTCPGVEELVRTELEAIFTDDSTLRAGLLRLHFHDCFVRGCDASLMLNSHNGTAEKHADPNLTVRGYEAIEAIKKVVEKACPLVVSCADIMAMAARDAVNFSAGPRYEVETGRRDGNVSMLEEALTNLPPADGNVTVLTQYFAVKNLTMKDMVVLSAAHTIGVTHCSSFSKRLYNFTGAGDQDPSLEPAYGKTLTTKCPTDKMASVVPMDEVTVAEFDLGYYESVYNHRAVLRSDAALLEDSLTGAYVALMNNASSLDI... | 14 |
Q7YSW8 | 3.1.3.16 | ACT_SITE 201; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q08209" | MSTNNNKAPTSQSSDKSATTESKLNDNENTETETKTDENNEEKPKMTLKPPQPKIENKVSTIDRVVPSVKYPKSLPLPHDVLFNEDKTINLPKLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSPEIREHFVPNDVRGCSYLYSYRAVCSFLQK... | 144 |
A0A3Q7IW37 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEKKIIQLLFICYFFHELIIVSSALQVGFYAKKCRAAESIVQQEVQRSFSTDRSITAALLRMYFHDCFVRVRNNIVYFVQGCDASILIDSKNTGNKQSEKDAGPNQSVRGYEVIDRIKSRVESACPSTVSCADIIALATRDSVALAGGPKYNIPTGRRDGLISNPSEVNLPGPSLTVEEALKFFTNKGFSLNDMVTLLGAHTVGITHCSLIQDRISRFDGSIDSNLFTRLSKTCAARNNDPSVFLDQSTSFIVDNEFYKQIRLKKGLLKIDQQLASDRSSAGIVENFSINPKAFQQAFANALIKLGNTQVLEGKFGEIRK... | 14 |
A0A059CUK2 | 2.7.1.11 | ACT_SITE 222; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MGLSSGDGTRMKVVTGDAGYVLEDVPHLSDYIADLPTYPNPLRSNPAYAVVKQYFVHVDDTVPQKVVVHKDGPRGIHFRRAGPRQQVYFETDEVHACIVTCGGLCPGLNTVIREIVCGLNYMYGVTKILGIDGGYRGFYSKNTITLNPKVVNDIHKRGGTILGTSRGGHDTMKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEIRQRGLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVENGIGVVKLMGRYSGFIAMYATLASRDVDCCLIPESPFFLEGKGGLYEFIEKRLKENGHMVIVIA... | 84 |
Q96285 | 2.7.11.1 | ACT_SITE 464; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSRELIILCQPILVLFLTLFYNSHGYFVSQGSVGIGFNGYFTLTNTTKHTFGQAFENEHVEIKNSSTGVISSFSVNFFFAIVPEHNQQGSHGMTFVISPTRGLPGASSDQYLGIFNKTNNGKASNNVIAIELDIHKDEEFGDIDDNHVGININGLRSVASASAGYYDDKDGSFKKLSLISREVMRLSIVYSQPDQQLNVTLFPAEIPVPPLKPLLSLNRDLSPYLLEKMYLGFTASTGSVGAIHYLMGWLVNGVIEYPRLELSIPVLPPYPKKTSNRTKTVLAVCLTVSVFAAFVASWIGFVFYLRHKKVKEVLEEWEIQ... | 99 |
H3G766 | 2.3.2.26 | ACT_SITE 367; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | LIQSMPYLVPFPDRVKLFQRLVKADKDVHQNESCSVYRIRIHRGAILEDGLKKLNSIRTNLKKRINVVFVNSAGREEVGIDAGGLFKEFWLDLSTLAFDLQYGLFLTTQDQLLYPNPNSASDHFSRESDHLTMFQFVVRILGKALYEGIVVQPKFAHFFLSKLLHSFNQLNELPSLDPEIYKNLMFLKSYDGDVEDLGLTHTVVQDVFGEQKEIEIIPGGGNVPVTSRNKTRYIHLVANYYLNTQIREQCAAFRMGLSDLIHPRWLQMFNEPELQVLISGKSGKIDVDDLKANARYAGGYYALDKRVAWLWQALASFTPS... | 65 |
A0A072U2X8 | 2.3.2.26 | ACT_SITE 1116; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDAPRKHQVSLRGASAKEITRDDLLQKVSRERELRNYAKRAASAALFIQRVWRRFKVTKMVALQLQQEWETSVNCYTGVMTSNWISNNLLRPFLFFVTRFSNHYQKVHSKKIDSMKICFTILLESLNSSDSERNFCFLAIGTTEDRRIWSYQAHRLSSLGFSILSEYSECNSGAQDITVVTSLAMRILVMLTDLKGWKGITDDNRLDADLAVKGLVEFTGSNKSGSYVSIAKYITALDKYSSKMKAITQADENFFITASAITLAVRPFYLTNLDGERPDMLNVNHAAKQYVVYLMTIPWFVQHVPHVLLPALKHKSILFT... | 65 |
A0L002 | 2.2.1.2 | ACT_SITE 132; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MANTLEQLKSYTTIVADTGDIEAIKRYQPEDATTNPSLILKAAQIPEYRALIDNAIAWAKLQSADIEQQIDDASDKLAVNIGVEILKLVPGRISTEVDARLSFDKEKSIAKAHKLVRLYQEAGVDKSRILIKLASTWEGICAAKELEQEGINCNLTLLFSFAQARACAEAGVYLISPFVGRILDWYKNDTGKDYDAVNDPGVVSVTEIYNYYKQHGYNTVVMGASFRNIGEIIELAGCDRLTIGPSLLEELANSQVAIQPKLLPASTTVAAGEPLTEAQFRWDFNQDPMAVDKLAEGIRNFAIDQGKLEVMLKAKLAN | 52 |
Q54GY6 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVGGLPNSSLWNIEYDDLVFKDIIGKGNFGCVYRGNYLGVEVAIKQIPSFDDPDYCKYTEREVKALRYIRHPFVVHFFGACKHESGFYLITEFIEGLDLRRYLKSVPKPPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVNIPSPNDCPIQFYDLALKCCSYKHTNRPMFSTIVTILESIKLQL... | 99 |
Q5KF65 | 3.5.1.98 | ACT_SITE 145; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MGSMEPILGESKRRVCYFFDSDIGNYHYGPGHPMKPTRIRMCHSLVMNYGLYKKMEIFRAKPATKREMSQFHTDEYVDFLYRINPDNAAQFAKEQVKYNVGDDCPIFDGLFEYCSISAGGSMEGAARLSRDKCDIAVNWAGGLHHAKKAEASGFCYVNDIVLGILELLRYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGEVRDNGIGKGKGYAINVPLRDGISDDNYKSIFQPVIKRVIEWYQPGAVVLQCGSDSLSGDRLGSFNLSMKGHAACVQFVKSFNLPLLLLGGGGYTVKSVSRTWAYET... | 184 |
A0A059BRL8 | 3.2.1.1 | ACT_SITE 203; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 228; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MMSSPSLFWLFVLLVFYLAASASPALLFQGFNWESSKKEGGWYNSLKNLVPDLANAGITHVWLPPPSQSAAQQGYLPGRLYDLNASSYGNQDELKHLIDAFHQKGIKCLADIVINHRTAEKQDSRGIWCIFEGGTPDERLDWGPSFICRDDTEFSDGMGNLDTGGDFNNTPDIDHLNPRVQKELSDWMNWLKSDIGFDGWRFDFVLGYDPSITKIYMDRTLPNFAVGENWDSLSYGQDKKPNPNQDAHRHKLAEWVNAAGGAVTAFDFTTKGILQAAVEGELWRLKDSNGMPPGLIGLQPSSAVTFIDNHDTGSTQKIWP... | 157 |
K4A0E0 | 3.1.1.11 | ACT_SITE 469; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSAFGDFGPLTERRKAEKARQQRRRIMIAVGTVSIVVVLIVAGSFAVMYSGKSSSEGHSKSSSGSKGSSSPAKGKSSGGGSHSASPSSSDSDSGSDSGSSDSQPDLKAVSKSIKAMCSQTDYTDACEKSLGKAATANATSPKDIVRAAVEVIGDAIGQAFERADLIMSNDPRVKAAVADCKEIFGDAKDDLNRTVKGVDAKDGIAKDGYQLRIWLSAVIAHMETCIDGFPDDDFKVKVKDSFTNGKELTSNALALIEKGSSILSAIKGSSKRRLLAEDEGAPASRAEPALDEDGIPEWVPDGERRVLKGGGFKSTLTPN... | 125 |
A9V5E8 | 1.2.1.12 | ACT_SITE 170; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MACLSCGTRDTPLTTTSNMAIKVGINGFGRIGRIVMRAAVSNPNVQVVSINDPFMDVDYMVYMFKYDSTHGKYAGSVEAKDGKLVIDGTVINVHACMKPEEIPWGTDGVDVVVESTGVFTDKAGASAHLKGGAKKVVISAPSKDAPMFVMGVNEDKYDAASMDIVSNASCTTNCLAPIVKVLEDEFGIVEGLMTTVHAFTATQKPVDAPARKDWRSGRGCAQNIIPASTGAAKAVGKVIPAVDGKLTGMAFRVPTPDVSVVDLTCRLDKAASYDDIKAAMKKAAEGPMKGVLAYTEEDVVSMDFRGDPHSSIFDAKAGIA... | 22 |
Q960X4 | 2.3.1.48 | ACT_SITE 431; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q9H7Z6" | MKINHKYEFDDDVASICESTAALTEGCRLPVRMHKTDDWPLAEIVSIKELDGRRQFYVHYVDFNKRLDEWVNEEDLYTRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSVPPPAGIPNSVAPPGTPSSGGELVNGNNLAAALQKRINRKRKNHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAANDDGDGSQDGKTPTPRQSGSMVTHQDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGNE... | 61 |
Q9HV35 | 4.1.1.50 | ACT_SITE 73; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 78; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 93; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000255|HAMAP... | MAIQPLRLDPITVLGKQLVIELFDCVDQRFDDIQWIEESMLEAARQANATIITSAFHKFSPIGISGVVVIAESHLAIHTWPEYGYAAVDVFTCGDVLDGAQAVRVLSERLGSRRHLISSMDRGLGGHRLGLLSRSLAGNGPVDEDSPTLRWALGQGTGVA | 196 |
D8QRG8 | 1.11.1.7 | ACT_SITE 37; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | FYSSSCPNAESIVRAAFSGNFITDPTAPAALLRLAFHDCQVGGCDASILLDSKGSIKSERDSDKNFGIRRLDFIDRIKSMLEAACPGVVSCADIIVLVARESIVFTGGPTIPVLTGRRDGTAASNAAADRLLPPATVSVDNFISLFASKGLSLDESVAIIGAHTIGVGHCVNIVNRLYPNQDSKIGLLFASRLRVQCPTANPRMLNNITVINNDMTNLVFDNQYFRDLMNGQGLFTIDSELALDSRTSPVVARFSTNQQLFLDTFSSAFVKLTSSNVLTGQSGQVRKYCHSVN | 14 |
Q54QM4 | 6.5.1.1 | ACT_SITE 283; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MSEDKSGSFYSMYKLCGQLEKESSHSGKTQLIKSFCNVFKGDLYLLAKLMLCKEDKRVFRIKDKAMLKICSHIWDCDLDDMIEDLDNGDFTETCKKFYIEYGKYPEKSTLTLKEVDQVLDSLTVSGKFEDQVKIINKLLKRCTPFDFRLVCRIIDSDLKINTGAKFFLDAFHPQAYDAFKKANNLKGVIEKIQQHDFDNDNGDGDDGDGDDNDDDDGDGDSDSDKKKKKSSGGSGSDSGSKKKSKSFEVAIKLMTPIKPMLPKAVKTVEGVVKSSECFYAEIKYDGERIQIHKDGNQFSCYSRNLKPLMPWKVDEVKPYI... | 254 |
Q54QM6 | 3.1.3.48 | ACT_SITE 957; /note="Cysteine persulfide intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00173" | MGPTENQSFEIEFPNSSNTAAANSISTAINNNTTTAATITFTPANNNINNINNNNNNNNNNKFNSNFDIESNKENSINQSNINSNVNSFPLKIQTKTLNSTTTSSNNNNNNIFSIGFRPLSPRGVSPRFHSNSSSSCSSEISTPSSSTFLEDPNLIASNTISSNNSINNNNNNNNNNNNNNNNNNNDNSNNNINTNNINNNNNNTNNGENPQKKQRNSQILSKNFYSLSLHADSPKHSRSTTDLSTFLGMSDPDVMTYRSKTFCISDFHQFDIDTTTNDNKNKNNNTKSTDESSTFDGKSSNSVENNNMTIINNNNNNNN... | 149 |
Q9XW33 | 3.1.3.16 | ACT_SITE 185; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MEKINTEDQKNVRNFVNKILEKIVFKWTHKTSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEFEALKDTTVRSRETGKRPQSEPHSTQPESSNDVKPPVAAPKSVNKEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDG... | 144 |
F7EYD5 | 2.3.1.286 | ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MALDPLGAVSLQSIMALSCRLVLAALRLWGPGGGRRPISLSVGASGGFGCGGHSEKKLSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQD... | 58 |
A0A2I2UWG3 | 3.1.1.4 | ACT_SITE 110; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 157; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MADGAQANPKVLRKKVLVRHPSGWRGPSLRASFPWRTSRSSLGMKKFFTMVVLAGSVLPAARSSLLNLKSMVETITGRSAILSFVGYGCYCGLGGHGLPMDEVDWCCHAHDCCYQKLFDLGCHPYVDHYEYTIENNTSITCSELNETECDKQTCECDKNVVLCLSNQTYNEKHRNYLNIYCQGPTPNCSIYEPPLEEAAYRHISPTPPAPP | 130 |
A8WNX0 | 1.2.1.12 | ACT_SITE 158; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MSKASVGINGFGRIGRLVLRAAIEKDTVQVVAVNDPFITIDYMVYLFKYDSTHGQFKGTVSSDGDFLIVQKGGKSSHKIKVFNSKDPAAIAWGSVKADYVVESTGVFTTKEKASAHLQGGAKKVIISAPSADAPMYVVGVNHEKYDASNDHVISNASCTTNCLAPLAKVVNDNFGIIEGLMTTVHAVTATQKTVDGPSGKLWRDGRGAGQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPDVSVVDLTVRLEKPASMDDIKKVVKAAAEGPMKGILAYTEDQVVSTDFVSDPHSSIFDAGACISLNPNFVKLVSWY... | 22 |
P0DV84 | 2.7.10.1 | ACT_SITE 1264; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGSVGLLGLLLLRLSVTASGSGAGTGSGTGSGTGTGTGQLVGSPATGPALQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPWSSSEPRAGWTEARGSLALDCAPLLRLLGPPPGVSWAEGASSPAPAQARTLTRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPSPEEVTAGLLQFNLSELFSWWIRHGEGRLRIRLMPEKKASAVGREGRLSAAIRASQPRLLFQILGTGHSSLESPTSLPSPPPDPFAWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLGNQSWSWRRVPSEEASQMDLL... | 97 |
O00103 | 2.3.2.23 | ACT_SITE 113; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MDSDMQNQNPHTNSKNSSSAGMAVDGHSVTKRLRSELMSLMMSNTPGISAFPDSDSNLLHWAGTITGPSDTYYEGLKFKISMSFPANYPYSPPTIIFTSPMWHPNVDMSGNICLDILKDKWSAVYNVQTILLSLQSLLGEPNNASPLNAQAAELWSKDPIEYKRLLMQRYKEIDEI | 64 |
A0A8R1Z758 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 117; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MLIVLSLFLLSISSVISRVIIGRYAGYQLDDMAMCELGWPMSEYNHYGCACSDLIRLAAVDQVDQCCERHNECYDSARSECGTLSPYYAFYSYKCESKKITCKDSIHSCAGYVCNCDKTFLDCLQKFPKPVEPVPKCKLTFYSSASHNKTSNE | 130 |
P0C1A9 | 3.1.1.11 | ACT_SITE 178; /note="Proton donor"; /evidence="ECO:0000269|PubMed:17717531"; ACT_SITE 199; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:17717531" | MLKTISGTLALSLIIAASVHQAQAATTYNAVVSKSSSDGKTFKTIADAIASAPAGSTPFVILIKNGVYNERLTITRNNLHLKGESRNGAVIAAATAAGTLKSDGSKWGTAGSSTITISAKDFSAQSLTIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYVSGGRSFFSDCRISGTVDFIFGDGTALFNNCDLVSRYRADVKSGNVSGYLTAPSTNINQKYGLVITNSRVIRESDSVPAKSYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIYGWDKMSGKDKNGNTIWFNP... | 125 |
A0A0K9NMZ6 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEKNIAGNLFWIAVLTIVLASATTQAQLQLGFYHRSCPKAESLIREFVQDHIPNAPSLAAALLRMHFHDCFVQGCDGSILLNVTTTTPTNATEKTAPPNLTLRGFDFIDRVKAVVEEECPGVVSCADVVALVARDSVVVTGGPSWNVPTGRRDGTISNATQALNGIPAPFFNFVNLTKSFAKVGLNVTDLVLLSGAHTIGIGHCSSFSKRLYNFTGVGDEDPSLDSEYAANLKKFKCKIPNDNVTFVEMDPGSVRTFDTHYYKLLLKRRGLFQSDAALTTDSNARDFVTNLVNGPPSNFFAAFGLSMEKMGRAHVKTGTQ... | 14 |
A0A2C9V3N3 | 3.2.1.1 | ACT_SITE 203; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 228; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGVIGASLSFLILTLSFWTNMSSSQILFQGFNWESWKKEGGWYNFLRNSIPELASSGITHVWLPPSSHSVSAEGYLPGRLYDLNASQYGNQDDLKALIRAFHNVGIQCIADIVINHRCAEKQDDRGIWSIFEGGTPDDRLDWGPSFICSDDTLYSDGKGNPDTGADFNAAPDIDHINLRVQRELSDWMNWLKNEIGFDGWRFDFARGYSPSFTKIYVANTKPSFAVGEIWKDLAYGNDGKPEYNQDAHRLDIVEWIRVAGEDVTAFDFTTKGILQAAIEGELWRLNDSNGGPPGVIGLLPGSSVTFIDNHDTGSTQNHWP... | 157 |
Q4WVG8 | 6.5.1.1 | ACT_SITE 322; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MDSDEIMPDEEHPNVPVGDEESDIDEKYPNRPRNHSPTLPFHELFQTLFNPLGEIKKKPAGAVAARRKVGPHGQSAANLNPLERRRDVIERFISRWRKEVGDDIYPAFRLILPDKDRDRAMYGIKEKAIGKMLVKIMKIDKNSEDGFNLLNWKLPGQAATSRMTGDFAGRCFDVISKRPMRTDVGDMLIEEVNEKLDKLSAASKEEQQLPILAEFYRRMNPEELMWLIRIILRQMKVGATERTFFDVWHPDAENLYSISSSLRRVCWELHDPNIRLDAEDRGISLMQCFQPQLAQFQMDSLDRMVARMRPTEEDPVFWIE... | 254 |
B3SD21 | 1.3.5.1 | ACT_SITE 263; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MGLSMAGFKTACISKLFPTRSHTVAAQGGINAALGNMEEDDWKWHMFDTVKGSDWLGDQNSIHYMTREAPKAVIELENFGMPFSRTESGKIYQRAFGGQSLKYGKGGQAHRCCCVADRTGHSLLHTLYGRSLKYDTHFFIEYFALDLIMKDGACIGVIAMDMEDGSIHRFRAKNTVLATGGYGRAYFSCTSAHTCTGDGTAMVSRAGLANEDMEFVQFHPTGIYGAGCLITEGCRGEGGYLINSEGERFMERYAPTAKDLASRDVVSRSMTMEIREGRGCGPDKDHVYLQLSHLPPETLRTRLPGISETAMIFAGVDVTK... | 28 |
U5G6X6 | 2.3.2.26 | ACT_SITE 1541; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGNRGQKRAEMVNELPSDKRACSSLEFRPSSSNSSIQTQINSENHNAETHDADMDTSSSGSASSHSDEEEPERDSAYGSCDSEGPRHSSLREYQRQRSSGDHSRLRDCLSNLTEGTEPSGQLAALTELCEVLSFCTEDSLSSTMADSLSPVLVMLSRLESNPDIMLLAIRALTYLCDVFPRASVFLVKHNAIPAICQRLMAIEYLDVAEQCLQALEKISRDQPLPCLQAGAIMAVLSFVDFFSTSVQRVALSTVVNICKKLPSENFSPFMEAVPRLCNLLQYEDRQLVENVAICLIKIAERVSQLSEMLDELCKHGLINQ... | 65 |
A0A3B3IM82 | 2.7.10.1 | ACT_SITE 535; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MRLDWMGPPRCVLLLLLLQLLQVQSRPTVEDPDPDAVKSSEDEEDDESSSEENKLSNELSASSENLQPMAPQWVMPEKMEKQLHAVPASMTVRFRCPATGNPVPTLHWLKNGEEFSRDQRIGGFKIKDHTWSLIMESVVPSDEGNYTCVVENEHGSLRHTYQLDIVERSPHRPILQAGLPANQTAVVGGDAQFVCRVFSDPQPHIQWLKHIVVNGSREGPEGHSFVQVLKTAGLNSTDKEMEVLTLRNVTLEDAGVYTCLAQNSIGMSYHSAWLTVLSEPPPSAVPSQTFLDIFFYCLGFSVIIVLAIAAVICRLYCTPK... | 97 |
H2MJD7 | 2.3.1.286 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSVNYAAGLSPYADKGVCGLPEKFDSPEELKEKVQTLAELVKESQYLVVHTGAGISTSAGIPDFRGPKGVWTLEEKGESPHFDTTFEDARPSLTHMALLGLERAGYLKYLISQNVDGLHVRSGFPRDKLSELHGNMFVEECEKCGRQYVRDKVIGVMGLKPTGRFCSVVRSRGLRGCRGKLISTILDWEDALPDRDLNRADDASRKADLALTLGTSMQIKPSGDLPLLTKRKGGRIAIVNLQPTKHDKQAHLRIHGYVDEVMKQLMEQLGLDIPKWEGPVVHESSEVLPDIKPPHCISADGKVKKEEIKIERKREATQLT... | 58 |
P44424 | 2.7.1.107 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P0ABN1" | MYKTTGLTHLINSTKYSLQGLKSAFKNETAFRHECFLACILIPLTFFLGETKIEIILMISSVLLVMALELLNSAVETVVDRIGTERHELSGRAKDQGSASVFIALCIVGIVWGGILFF | 83 |
M5XBP5 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATQKLISVLLLQLLLVLLASDFSNGQKLKVGFYHKTCPNLEAIVAKTTQHYISRAPTLAAPLLRLHFHDCFVRGCDGSVLLNSTASNSAEKDAIPNLSLRGFHVIDAAKSAVEKKCPGVVSCADILALVARDAVRMLPGSFWEVPTGRRDGRVSVNSEALRGLPSPFANITQLKAKFASKGLSVKDLVVLSGGHTIGTSHCDSFSSRLYNFTGKGDTDPKLDKNYIARLKKKCKPGDTKTLVEMDPGSFKSFDEDYYTLVAKRRGLFHSDSALLDDPETRAYVIQQATSHGGATFLKDFGASMVNMGNIGVLTGNSGEI... | 14 |
P27638 | 2.7.11.24 | ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASATSTPTIADGNSNKESVATSRSPHTHDLNFELPEEYEMINLIGQGAYGVVCAALHKPSGLKVAVKKIHPFNHPVFCLRTLREIKLLRHFRHENIISILDILPPPSYQELEDVYIVQELMETDLYRVIRSQPLSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSNLLLNANCDLKVADFGLARSTTAQGGNPGFMTEYVATRWYRAPEIMLSFREYSKAIDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTPTMDDFSRIKSARARKYIKSLPFTPKVSFKALFPQASPDAIDLLEKLLTFNPDKRITAEE... | 104 |
F2E2L4 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGAVKNLVKLLILVEVAVALAGPGVAALSMNYYGMNCPFAQYIVQSVVRDAVMDDPTLAAGLLRLHFHDCFVQGCDASVLLDSTPGSKAEKEAQANKSLRGFEVIDKIKDTLEAQCPGVVTCADILALAARDAVLMVGGPYYDVPQGRRDGRRSVDTDTLTALPSPFLNASALITLFGTHGFNVQDMVALSGGHTLGVAHCPAFTPRLKFEASTLDAGFASSLAATCSKGGDSATATFDRTSTAFDGVYFKELQQRRGLLSSDQTLYESPETQRLVNMFAMNQGYFFYAFTQGMGKMGQIDLKEGDRGEVRKSCRVVNKP... | 14 |
F4NUC7 | 1.1.1.8 | ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MERVALIGSGNWGSAIAKIVGRNIIKQPNFHKEVRMWVFEEIVSGQRLSHIINSTHENVKYLPNIKLPENVVAVPELLKSVEGATLLVFVIPHQFVKGVCDQLKDKISINARAISLIKGVDAGGSSGLSLVSDIIRDSLKIDVSVLMGANIASEVAQENFCESTIGYSIKENADVFQKIFNTPYFRINCVQDVAGVELCGALKNVVAIAAGLVDGLKCGENTKAAIIRIGLLEMKKFAKTFYEGIKDETFFESCGIADVITTCFGGRNRRLAEARVLTGKSFEMLEEEMLNGQKLQGSLTSRDIHEILVHRNLVSEFPLF... | 7 |
A0A3B6LVM8 | 3.1.1.11 | ACT_SITE 446; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAMPRSAPAEPDESASRTKLLVGGIAAFLLLAIIIGTAAFIVSERAEDEGETNKKAMAATMRTVDLFCSPTDYQATCKETLTKPLERSDNQVDHPHAAAAAAITAVGRELSRGFNESSLLEAVRQSNDTLVHEALLDCKMLLDDCAADVTRALSTVAWRGVDGPAQDLQAWLSAVITFQGSCVDMFPKGDVRVQIKEIMEKAREISSNAIAIIQQGAALAAMIEIDAGAKVTLPNDADDDDDDDDDNNGKDDTPAEQSDGERQLQESVSDVPTWVPSEDRRILEEAEEERNGVLTPNVTVAKDGSGQFTNISAALDALPK... | 125 |
B4MLR8 | 3.4.19.12 | ACT_SITE 221; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 492; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MPVSLAVCETTTTTTANVVNAALRESLLGGSRSGAAVAGSGSASSLISGAGGAGASAANDDDSSSTATANTNLQNQIVASAKRVLLAKIEYEEVENYNDSVLDNLKTKYVVIKSPTPAAAAAATNNGNSNSAGSKILGANGHDNRQKQQNANGGCSTPTTTTTQTSSSSTSSSSIEHNNNPNELPKPKRVLYQRENIRIGWKQSERKWQIGAGMINVGNTCYLNSTLQALFHIPALANWLNSEQSHLENCNIGGESGGGGGGGGGNNGGFCIICAMAKTLQSTQSNASAIRPYHIYSKLKQICKHMVIGRQEDAHEFLRF... | 175 |
O66855 | 1.3.5.1 | ACT_SITE 280; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MEIKKYDVVVIGGGGAGLRTAIEVAKDPNISVALVSKVYPTRSHTGAAQGGMNAALGNVIPDDSPEVHAYDTIKGSDFLADQDAVFFMTEKAPEIIYELDRWGVPFSRLPDGRIAQRPFGGASFPRTVFAADKTGHVLLHTLFEQALARDNITFFNEYFLLDLIHDGERVKGVTIYDIRNGEVLFLQAKAVVLATGGFARIYWFRSTNAIGNTGDGQAVALRAGVPLKDMEFIQFHPTGLAKTGILLSEACRGEGGYLLNKEGERFMKRYAPDKMELAPRDIVSRAIETEIREGRGVGEGARAYVYLDLRHLGEEKIKER... | 28 |
A0A251NSL7 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNMSSTAAVAVVAIGLVFLTFAGQCSGALEVGFYQGKCGRFVDVEGIVAGIVRTKFFRDRTIAAALIRMQFHDCFVNGCDASILLDGSASEKTAPPNLSVRGFDVIDAAKTAVESVCRGVVSCADIIAIATREAVYLSGGGRYNVQTGRRDGLISLAANVDLPAPSISVPDSVAAFARKGLNMTDMVHLLDRLYNFQNTGKPDPDMNVALLGRLRRICPQNSAGTNTTNLDQNPQSSFIVDNSFYKEIVARRGILQIDQELALDPTTQATVTALANSGTNSFATKFGQAMVKLGAVEVLTGSQGEIRRSCRAVNKPGFLT... | 14 |
Q9H3M9 | 3.4.19.12 | ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:21118805, ECO:0007744|PDB:3O65"; ACT_SITE 119; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:21118805, ECO:0007744|PDB:3O65"; ACT_SITE 134; /evidence="ECO:0000305|PubMed:21118805, ECO:0007744|PDB:3O65" | MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRA... | 175 |
B5YHS5 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164"; ACT_SITE 604; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164" | MCGIIGYIGDKNAIQIVLDGLKKLEYRGYDSAGIACLLNGKIKTVKCKGKIKNLESLVDDSLKQSKIAIGHTRWATHGKPSDENAHPHCSGSIALVHNGIIENYAEIKKELQTEGYKFVSQTDTEVIAHLIRKYRENNLSLEDSIRKAVSRLRGSYAIVIMDDKEPDKLIGVRMESPLVVGISDGEKFIASDVPAFLNHCNKALFLEDGEMIVLNKEGFRVYNLEGKEKKKTPITITWTASMAEKGGFKHFMLKEIYEQPRALSDTIRGRVLSDQGKIVFEEFGLTRDEMRRIEKIYLVACGTSYHACLIGEYIIENIAQ... | 81 |
A0A251SCE5 | 3.4.19.9 | ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 263; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 263; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MWKYTWIPIILTIISLQTSFTKPESTIHYSPTVMKSTCPSPDPTLNHRPIIGIVSHPGDGASGRLSNATNASYIAASYVKFVESAGARVIPLIYNEPITNLQAKLSLVNGVLFTGGWSKSGLYFDVIEGIFKQVLKKNDEGEHFPLLAICLGFELLTMIISKNNNILEDFSASDQASTLQFMRNINLEETLFQRFPPELIAKLSTECLVMQNHKYGISPETFQGNTELCSFFKILTTSADQNGKVYVSTVQSESYPVTAVQWHPEKNAFEWGSSEIPHSDDAIQVTQHVANFFVSEARKSLNRPPAEQVLANLIYNYSPT... | 176 |
I1MGT1 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKNSSLPLLLLLVLYTISASSRPYENYDDKSSLSSTISETVFSLQVPALDETTFDNLLSFGYYRKTCPQFESILHNKVKEWIQKDYTLAASLMRLHFHDCSVRGCDGSILLKHDGSERTAQASKTLRGFEVVDDIKAELEKQCPKTVSCADILTAAARDATVELGGPYWAVPYGRRDGKVSIAKEADMVPMGHENVTSLIEFFQSRGMAVLDLVVLSGAHTIGRTSCGSIQYRLYNYQGTGKPDPTLDPKYVNFLQRKCRWASEYVDLDATTPKTFDNVYYINLEKKMGLLSTDQLLYSDARTSPLVSALAASHSVFEHQ... | 14 |
A0A804IJN5 | 2.7.1.11 | ACT_SITE 279; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MQSEAADTRIDAAAESHEPQSPTGRQIIDFELRNSLPRVRATSPSSADPPPGPAAASLVMGTDPGSTIKIVKGEFGYVLEDVPHLTDYLADLPTYPNPIKENPAYSVVKQFFVNQDDTVPKKVVVQKDSPRGIHFRRAGPRQRVYFESDDVNACIVTCGGLCPGLNTVIREIICGLSYMYDVNKVLGIEGGYRGFYARNTIQLTPKSVNDIHKRGGTILSTSRGGHDTLKIVDNIQDRGINQVYIIGGDGTQKGAAAIFEEIRRRRLKVAVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEAESVENGIGVVK... | 84 |
H2LF27 | 3.4.19.9 | ACT_SITE 137; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 248; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 248; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MSKKGFKVEMFLVFLCWFGCSRAVPLKPNQEAVNDRPVIGILTMIVSDETMKPFGKTYIPASYVKYIESAGGRVMPIRLTLTTTEYEKIFKSINGLLFIGGATDLETSDFARVARIFYKLALEANDAGDYFPIWGTCLGMQLLTVLVAGENLLSRTTAENVALPLNLTTEAQSSRMLKDFPEDLVKAITQEPLTGNFHHYGLSVQSFQENEKLRSFFSLLSTNIAENGAHFVSTFEGKRYPIYGVQWHPEVNRFQWNRNLNFPHSSHAVHLSSLLAEFFINEGRRSSHHFDNLEEEESSLIYTNTPLYTGNFTAYEQVYF... | 176 |
A0A7I4E3X7 | 3.1.3.16 | ACT_SITE 294; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MAAQVVEEPPVVDAAKAEKLKAAANAAFQANKFSSAIELYSQAIDLNSQNAVYWANRAFAHTKMESYGSAIEDATKAIEIDPKYSKGYYRRGAAYLALLKFKEAFKDFRQVQRMVPNDPDAIKKLRECEKAITKIKFEEAIAIKDEEIHSIAETLDYHTIEVEKSYQGARIEDDKISLDFVKKMMDDFKQQRSVHSRYAFQILMQTREILLATPTLVHITVPDRGHFTVCGDIHGQYYDLLNIFKLNGLPSEENPYLFNGDFVDRGSFSVEVILTLFALKCLYPTGLYLSRGNHESKSMNKIYGFEGEVNAKFNETMTKL... | 144 |
B9RN36 | 3.2.1.14 | ACT_SITE 98; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MATSSLTLLLSFFFYSTLLSFAAYKAEARKFPISSLITKDLFDSIFLHKDDTACPAKDFYTYDSFIQATRCFPRFGNTGSLATRKREIAAFLAQISHETTGGWATAPDGPFAWGLCFKEEVSPQSDYCDSTNTQWPCFPGKSYKGRGPIQLSWNFNYGPAGKALGFDGLKNPEIVSNNSLIAFKTGLWFWMTEQKPKPSCHRVMVGKYVPTKADLAANRTAGYGLVTNIINGGLECGIPNDSRVNDRIGYFQRYAKLFNVGTGPNLDCQNQKPFS | 158 |
F4PEG0 | 1.1.1.8 | ACT_SITE 220; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MGQTLSRRDSVTATLDLTDGASSTDSLQERVLVVGGGNFGTCLADHLADKGNSVTIWARDQSLVDGIMNDHINHKYIPGIQLSPGLKATSVLDANTIQSATVIIMSIPTQYMRSILEKIRDHLTVNQLLVFVNKGIEESSGLLPNDIAIQVCGIEIGERAAFLSGPSFAAEVVKRQPSCVSVASRSPLRSKRTQRLFHAPHFRVYEIHDTIGVEVAGALKNVIALAAGACAGVGFQMNSRAALITRGLAELARFGVALGANPLTFAGLSGVGDLLLTCTSEKSRNFTVGYRIGKGETLEEIITSLGSVAEGVATTKAAYA... | 7 |
A0A1S4GWA8 | 2.7.10.2 | ACT_SITE 394; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1" | MEIHTESSGIDSSPDMNSSVELNSSPQRSSTVMPRKLTFGNSPEPMHNSAAEQHQQQQNRNQPSLSPPYRKVQALRLFDTPATPKTILQKSTNTMFRRQVFGPGTTLFPSASSGAEQADLLAQPMDGGLPIFTTDKPKPVPLHRRYDVGLPPANVNPFTPPAMFMRTKKRTRQEGPESAKATLGHGGIGTGTANTIRSHNFPTMFPSNRLNKCRLPFSGPPTPFALKQPNDSTTNHTLKAFNMVEDEYGDFRQAPKRLALQDSNISRYEKEFIQLSLLGTGEFGQVYQCLNRLDGCIYAIKKSIRPVAGSSFEKTALNEV... | 98 |
Q9LY50 | 2.7.11.1 | ACT_SITE 631; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKRFINSTVTFSVTVTIAVIIFFLLSPVTSLGSGSTYAVVYGSDTVCALISGQPTQRILCYDTRLNINVTLNPGVSFSSIAAGDNFLCGIRSGGYSLLCWDNIGSYSPNRKRIYQNDNVLLETLSVGDKQICATVNGTNSLKCWRGSVSDQSKPPNERFRSISSGVGFSCGVSIRNNRILCWGTDPVKSNQIQTGFGNTPMVTISAGKSHACGLNTTGNLICIGNNDSGQLNVIAPDQPNLYSSSLSLGSNFTCAMRISNNSVVCWGGGAERFNNVTDSISFESISSGPGLICGLISSNLSIMCWNPTNFSRIFLPFPEV... | 99 |
D7SYK3 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDHLKKLSTVLCFLLLQFGVEGRGLSYSIYQKSCPQVEDIVRAALGPIFLSDPSSPPAFLRLLFHDCQVQGCDASILVDPAGGKTPLEMASSKNFGVRKRESISLIKSVVEAQCPGTVSCADILVMAARDAVAFSGGPWIKVPFGRRDSSRATSYKLADALLPPANVDVNGLLQIFTQKGMTIKEAVAIIGAHTIGITHCLNIRDRLQRPEGGGRARGMEPGFEAFLRLSCPEGSLISNSTFVVNDPSAFTFDNHYYSNAMHGRGILRVDAEVSSDSRTAPIVSSFAADQSEFFRYFASAFVKLSTSGVLTGNQGVIRKS... | 14 |
A0A9R0IA94 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGSSKFLPFLQLVLCSLLLGISNGQSIVPVVPGLSYTFYDSNCPGLEIIVRSHLWEVFNNNITQAAGLLRLHFHDCFVQGCDGSVLLDGSTSGPSEQDAPPNLTLRAAAFTIIDDLRALVHNACGPIVSCADIVALAARESVFLPNGPYYQIPLGRRDSVNFATRPVTLANLPPPTFNTTSLINAFAAKNLTTTDLVALSGGHTIGRGHCASFANRLYPTQDSTLDQTFANNLKLTCPTNTTDNSTNLDIRSPNLFDNKYFVDLMNRQGLFTSDQDLYTDSRTRNIVTSFAVNQSLFFEKFVVGMLKMGQLGVLTGTQGE... | 14 |
Q8J308 | 4.1.2.13 | ACT_SITE 191; /note="Schiff-base intermediate with dihydroxyacetone-P"; /evidence="ECO:0000250" | MDAYQSVGIRRRLKRFFRRDGRALIFAMDHGFEHGPTDFEPVWEHVNPRIIIRKVVRAGVDGVMMLPGIVRMAGDELKPDTGLMIKLTSKTELRPKEEQLLQSQLGYVEDAIKLGADAIAATVYWGSPQEDVMMRQFAEIASYAHDLGFPVVQFAYPRGPYINEKYGKKEDYRVVMYGARAAAETGADMIKTYWTGSKETFAKVVDAAAGVPVLLSGGAKTDNPVDFLKVVWDVIEAGGAGAVVGRNIFQRENPEPMIKALIRVIHRNEDPEEAAKAEGLI | 197 |
A8GQB7 | 1.3.3.3 | ACT_SITE 116; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MKIENKEITSNWFTNLRDLLCKEFEKIEEEYAQTKCLKPAKFVRTSWQRNGGGGGIMSLMKGEVFEKVGVNISTVFGEFSPEFRSEIPGAELDGKFSATGISLVAHLKSPLIPAMHFNTRYIETSKSWFGGGGDLTPFYPEENETEKFHAAFKEACDKYDSGYYPKFKKQCDEYFYLKHRKEPRGVGGIFYDYLNSGNFEQDFSFTQDVGMALLSVYPEIVRSKLFLPWTAEQKEYQLIRRGRYVEFNLLYDRGTKFGLMTDGNVEAILMSLPPEVKFN | 27 |
A0A078FDK8 | 3.1.1.11 | ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAVGKIVISVASMLLVVGVAIGVVTFVNKGGGAGGDKTLNSHQKAVESLCASATDKGSCAKTLDPVKSDDPSKLIKAFMLATKDAVTKSTNFTASTEEGMGKNMNATSKAVLDYCKRVLMYALEDLETIVEEMGEDLQQSGSKMDQLKQWLTGVFNYQTDCIDDIEESELRKVMGEGIAHSKILSSNAIDIFHALTTAMSQMNVKVDDMKKGNLGETPAPDRDLLEDLDQKGLPKWHSDKDRKLMAQAGRPGGGGGGKIKPTHVVAKDGSGQFKTISEAVKACPEKNPGRCIIYIKAGVYKEQVTIPKKVNNVFMFGDGA... | 125 |
F6Y6I2 | 4.1.1.17 | ACT_SITE 325; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MNSFSNDEFDFNFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWYKALPRVTPFYAVKCNDSRAILKTLAAVGAGFDCASKTEIQLVQSLGVPPGRIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLSIATDDSKAVCRLSVKFETFVQAVSDARCVFDMGAEFGFNMYLLDIGGGFPGSEDVKLKFEEISSVINPALDKYFPPDSGVRIIAEPGRYYVASAFTLAVNIIAKKLVLKEQTGSDDEDEANDQTFMYYVNDGVYGSFNCILFDHAHVKPLLQKRPKPDEKYYSSSI... | 195 |
A0A3Q7FU03 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAYFVPLLSTFIFFSIYYSQSNALSSNYYAKTCPQAEDIVMKVVKEEAQKDRTVPATLLRMHFHDCFLRGCDASILLSSKGKNTAEKDAPPNGSLHGFYVIDGAKRAVEAICPGVVSCADILAFAARDAVVLSGGPYWKVPKGRKDGRISRASETTLLPKPTFNISQLQQSFHQRGLSLDDLVALLGAHTLGFTHCSSFMNRIYNFNATHDIDPTLRPSFAASLKGICPLKNRAKNAGISNDPSPTTFDNTHYRLILQKKSLLFSDHSLLTIPKTKSLVYKFATSKAAFHKAFSNSMIKMSSLTGGQEARLEIVIYSPYH... | 14 |
A1Z9X0 | 2.7.11.13 | ACT_SITE 388; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQKMPSQILNDGSSVSLNSASMNMANTPNSITVKTAYNGQIIITTINKNISYEELCYEIRNICRFPLDQPFTIKWVDEENDPCTISTKMELDEAIRLYEMNFDSQLVIHVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETAS... | 100 |
Q8EEH1 | 5.6.2.2 | ACT_SITE 122; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MTDLASSISPINIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELKNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYTLVDGQGNFGSVDGDSAAAMRYTEIRMDKLAHQLLADLEKETVDYVPNYDGTEQIPAVLPTRVPNLLINGSSGIAVGMATNIPPHNLTEVVKGCLALIADPALSIEQLMDYIPGPDFPTAAIINGRKGIIDAYKTGRGRAIMRALAEVETEENGRERIIVTEIPYQVNKARLIEKIAELVKDKKLEGISGLRDESDKDGMRIVIEIKRGEVGEVVLNNLY... | 222 |
P39524 | 7.6.2.1 | ACT_SITE 560; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000305|PubMed:19411703" | MNDDRETPPKRKPGEDDTLFDIDFLDDTTSHSGSRSKVTNSHANANYIPPSHVLPEETIDLDADDDNIENDVHENLFMSNNHDDQTSWNANRFDSDAYQPQSLRAVKPPGLFARFGNGLKNAFTFKRKKGPESFEMNHYNAVTNNELDDNYLDSRNKFNIKILFNRYILRKNVGDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFLCTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADT... | 259 |
Q0UT91 | 3.2.1.23 | ACT_SITE 191; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 270; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MKVFKAVSFLAAVQAVAATPITDFSDLSDAAQANSTFSWDKNTFYIEGKPYSIIGGQIDPQRVPRAYWPQRLQMAKSMGLNTILSYVYWQDIEQHPGQFDFTDKNDIAAWFQEIQKAGMKAVLRPGPYVCAERDWGGMPGWLPQISGMKHRSNNGPFLDATNKYLTKVGAQLQPLLIANGGPILMVQVENEYGWAGSDHTYTNKLADILKANFPNTKLYTNDANNAGALKNGQVPGALAVFDGTDMKNGVTTLRSAITDASSIGPAMNGEYWIRWFDNWGPKNGHSSYDRDTNGMQGRANDLDWMLTNGHHFSIFMFHGG... | 163 |
A0A2C9UR19 | 2.1.1.37 | ACT_SITE 1232; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MGSAALLDSVDENSDSESGMKKNKGKTKSSVSSASKVLTSREKVKKRNCSHRKEEVAVSWKRPKRAAACTDFKEKSIHLSEKISVLELKNDQFADEEIIAIHLTHEQDEGRPNRRLADFVVHDANGTPQPLEMIEVDDMFISGLILPLEEGPEREKEKRVRCEGFGRIEGWSISGYEDGSPVVWLTTDIADYDCLKPASSYKKFYDHFFEKAHVCIEVYKKLSKSSGGNPDLALDELLAGVVRSMIGSKCFSGAASIKDFVISQGEFIYNQLIGLDETSKKNDQKFAGLPVLLALKGKSREHGNFVLAKAASSGGNLMIC... | 47 |
Q6FND4 | 3.1.3.3 | ACT_SITE 90; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 92; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MSFVVTVIAHGDALRSEKELVDRVVGALDAELIKTETLSKRAVDIFVKAPGEVLQLKQKLDQLDVDGADLAVQVVDEQLQRRPLKLCVFDMDSTLIYQEVIELIAAYAGVEPQVHEITERAMNNEIDFKQSLRERVRLLKGLKIDNLYEEIKQKLQITEGVPQLCSTLKQHGIKLAVLSGGFIQFASYIKDQLSLDYARANLLEMDDSGVLTGEVIGEIVDGQCKAETIKQLCKDWSIDLENVCMIGDGGNDLPSMHVSGYGIAWNAKPTVQKQAPSKLNTKSLADALYIFGIIE | 147 |
P0A8Y1 | 3.1.3.5 | ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000250" | MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLNVEPGKLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHHREQPEGIAPTWTVSSLHELEQLLCKH | 150 |
A0E3Q5 | 3.5.1.98 | ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MIQTDSDSSRRVAYFYNRFIGKFQYGKEHPMKPKRIIMAHNLIVNYGYLFRQMDVYLIREAQLQEIGKFHDPDYIIYLSQFMSQNKINFVKEYCSANNESVIPENLLEEFKLIIKWSQQQKVKTENSEFKVGDSPDNPTFSGLFSYCQLSSGASIDCAHSILTGQADIAINWSGGLHHAKKKEASGFCYINDIVLCILELLRVYVRVLYVDIDCHHGDGVEEAFYLTNRVMTLSFHQYGDDFYPGTGQLNSVGVGVGRYYSVNVPMKPGMSDQPYIEMFKKITSRVMQVYRPDCIVMQCGADSLSLDKLGGFNLSIKGHG... | 184 |
A0A067HG98 | 3.1.1.11 | ACT_SITE 195; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYYLNSFLFAVTLLLLSSNVSTALDCKLNNANPLKVAYTISVSRSGGGNFTKIQDAINFIPVNNDQWIRIQISPEIYQEKVTIPQNKPCIFLEGASSRTTKIQWGDHDTTISSPTFTSLSENVVAKGILFQNTYNVPPSYRQNQERMEVKQALAARISGDKSAFYNCGFAGLQDTLFDDHGRHYFHQCYIEGAIDFIFGNGQSIYHNCAVNVTLKEYLPEKDYGYITAQGRNSTDDPSGFVFTSCQFLGSGKAYLGRAYGAFSRVIIVNSVLTDMVEPQGWNAWNHVEHEENIEYAEARCRGAGADTSKRVSWEKHLSVD... | 125 |
I1H4G2 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAAWLAALAFALAPLLCASEGNGTGIAFGYYNATCPEAETIVFRETARILRASPDLAASLLRLHYHDCFVQGCDASVLLDTTDAANPTEKDGKPNESLRGFDAVARVKDKLETACPATVSCADLLALMARDAVLLSKGPRWAVALGRRDGRSSSAGNCGELPPLYGNMTVMVEVFAGKGMDAKDIAVLSGAHTLGKAHCSSFADRLYSGANATCVTDPALDGRYAARLRLRCPGNNGGNGGAAAEMDAGSCGTFDTSYYRHVASKRGLLQSDAALMEHPVTAAYVRRAATGRYDGHFFSDFAESMAKMGAVGVLTGDQG... | 14 |
A0A3B3HCD9 | 2.7.10.2 | ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000604-1" | MQSSLYSLPLCVCECVAVVVFLPLLFTEPDSVARSTDASLTLKWQHCSCEAVKFSQSELYPGLPEPRLADIPGFRMSVDPAIELPFFYGSISRSDAEQQLKLGGMADGLFLLRHCLRNLGGYVLSVVWNLEFHHYSIEKQLNGTYCIAGGKPHCGPAELCEFYSKDPDGLVCILRKPCLRPPNTPIKMGVFDKIRVNMLREYVRQTWNLEGEAMEQAIISQAPQLEKLIATTAHEKMPWFHGKINRHEGERRLYSGAQPDGKFLVRERDEPGTFALSVVYGKTVYHYQIVQDKSGKLSVPEGTKFDTLWQLVEYLKMKPD... | 98 |
P70973 | 5.4.99.12 | ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRIPVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHARFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAAKTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVKSMLEAKDREAAGRTAPGHGLYLWNVYYDN | 217 |
A7RWL7 | 4.1.1.17 | ACT_SITE 362; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MKQSIGTDLAIEIVKDGLSHRDVITEKIDSLGREEKDDAFYIVDLADVVLKHKKWVQLLPRVEPFYAMKCNNDPAVLKLLAGLGLGFDCASKGEIQTILGLGVSPKKIVYANPCKQASHIKYASQHDVAMTTFDNEMELHKIKKLYPDAQLILRIRTDDSKSLCQLGIKFGAPLKQCRHLLKVAQDLGLNVVGVSFHVGSGCFDASAYATAVIAARSVFNLAVQFGFNCTLLDIGGGFPGDPNAAITFEEICTTINPLLEEHFPPSSGVRIIAEPGRYYSSSSFTLAVNVYSRREVQSSSVLAEDVTAPENNGNQGFMYY... | 195 |
P52490 | 2.3.2.23 | ACT_SITE 87; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MASLPKRIIKETEKLVSDPVPGITAEPHDDNLRYFQVTIEGPEQSPYEDGIFELELYLPDDYPMEAPKVRFLTKIYHPNIDRLGRICLDVLKTNWSPALQIRTVLLSIQALLASPNPNDPLANDVAEDWIKNEQGAKAKAREWTKLYAKKKPE | 64 |
A0A0A0L9Z8 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 121; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 136; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MDGACNGGMLYHEVQESKLCAVHCVNTVLQGPFFSEFDLAALASDLDRKERQMMLSGSTTGDFLSEESHNVSLDGDFSIQVLQKALEVWDLQVIPLNSPVAEPAQIDPQLENAFICHLQDHWFCIRKVNGEWYNFDSLYAAPQHLSKFYLSAYLDSLKGFGWSIFIVRGNFPKDFPISSSEASNGYGQWLSPEDAERITKSCNSTQAPPPPQRANWTEQQDTFLSSGETEMLIDMEDEDLKAAIAASLMDSSAVMAAGVANPPNEPVVSSTQAGSPQNVPAVALETANTQDVLAVSPNASILEDVPAVSPEAATLQDVPA... | 175 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.